Beilstein Reg. No. 3810313, Beilstein Reference No. 4-26-00-04195, 1953. |
Allan Y. Chen, et al., "DNA Topoisomerases: Essential Enzymes and Lethal Targets", Annu. Rev. Pharmacol. Toxicol., 34, 191-218 (1994). |
Allan Y. Chen, et al., "DNA Minor Groove-Binding Ligands: A Different Class of Mammalian DNA Topoisomerase I Inhibitors", Proc. Natl. Acad. Sci., USA, 90, 8131-8135 (Sep. 1993). |
Allan Y. Chen, et al., "A New Mammalian DNA Topoisomerase I Poison Hoechst 33342: Cytoxicity and Drug Resistance in Human Cell Cultures", Cancer Research, 53, 1332-1337 (Mar. 15, 1993). |
Peter D'Arpa, et al., "Topoisomerase-Targeting Antitumor Drugs", Biochimica et Biophysica Acta, 989, 163-177 (1989). |
Robert C. Gallo, et al., "Studies on the Antitumor Activity, Mechanism of Action, and Cell Cycle Effects of Camptothecin", J. of the Natl Cancer Institute, 46, 789-795 (Apr. 1971). |
Beppino C. Giovanella, et al., "Complete Growth Inhibition of Human Cancer Xenografts in Nude Mice by Treatment with 20-(S)-Camptothecin", Cancer Research, 51, 3052-3055 (Jun. 1, 1991). |
Qun Sun, et al., "Structure Activity of Topoisomerase I Poisons Related to Hoechst 33342", Bioorganic & Medicinal Chemistry Letters, 4, 2871-2876 (1994). |
Bathini Yadagiri et al., "Convenient Routes to Substituted Benzimidazoles and Imidazolo�4,5-b!pyridines Using Nitrobenzene as Oxidant", Synthetic Communications, 20 (7), 955-963, (1990). |
Abdallah Cherif, et al., "N-(5,5-Diacetoxypent-1-yl) doxorubicin: A New Intensely Potent Doxorubicin Analogue", J. Med. Chem., 35, 3208-3214, (1992). |
G. J. Fox, et al., "para-Bromination of Aromatic Amines: 4-Bromo-N,N-Dimethyl-3-(Triflouromethyl)Aniline", Org. Syn., 55, 20-23, (1973). |
Masamoto Iwao, et al., "A Regiospecific Synthesis of Carbazones via Consecutive Paalladium-Catalyzed Cross-coupling and Aryne-Mediated Cycilization", Heterocycles, 36, 1483-1488, (1993). |
Dan Peters, et al., "Synthesis of Various 5-Substituted Uracils", J. ., 27, Heterocyclic Chem., 27, 2165-2173 (Nov.-Dec. 1990). |
J. R. Piper, et al., "Synthesis and Antifolate Activity of 5-Methyl-5, 10-dideaza Analogues of Aminopterin and Folic Acid and an Alternative Synthesis of 5,10-Dideazatetrahydrofolic Acid, a Potent Inhibitor of Glycinamide Ribonucleotide Formyltransferase", J. Med. Chem., 31, 2164-2169, (1988). |
Malvinder P. Singh, et al., "Synthesis and Sequence-Specific DNA Specific DNA Binding of a Topoisomerase Inhibitory Analog of Hoechst 33258 Designed for Altered Base and Sequence Recognition", Chem. Res. Toxicol., 5, 597-607, (1992). |
Allan Y. Chen, et al., "A New Mammalian DNA Topoisomerase I Poison Hoechst 33342: Cytoxicity and Drug Resistance in Human Cell Cultures", Cancer Research, 53, 1332-1337 (Mar. 15, 1993). |
Allan Y. Chen, et al., "DNA Minor Groove-Binding Ligands: A Different Class of Mammalian DNA Topoisomerase I Inhibitors", Proc. Natl. Acad. Sci., USA, 90, 8131-8135 (Sep. 1993). |
Allan Y. Chen, et al., "DNA Topoisomerases: Essential Enzymes and Lethal Targets", Annu. Rev. Pharmacol. Toxicol., 34, 191-218 (1994). |
Peter D'arpa, et al., "Topoisomerase-Targeting Antitumor Drugs", Biochemcia et Biophysica Acta, 989, 163-177 (1989). |
Robert C. Gallo, et al., "Studies on the Antitumor Activity, Mechanism of Action, and Cell Cycle Effects of Camptothecin", Journal of the National Cancer Institute, 46, 789-795 (Apr. 1971). |
Barbara Gatto, et al., "Identification of Topoisomerase I as the Cyctotoxic Target of the Protoberberine Alkaloid Coralyne", Cancer Res., 56, 2795-2800, (1996). |
Beppino C. Giovanella, et al., "Complete Growth Inhibition of Human Cancer Xenografts in Nude Mice Treatment with 20-(2) -Camptothecin", Cancer Research, 51, 3052-3055 (Jun. 1, 1991). |
J. S. Kim, et al., "Influence of steric factors on topoisomerase I inhibition and cytotoxicity of bisbenzimidazoles related to Hoechst 33342", Abstract 4, 86th annual meeting of the American Association for Cancer Research, Toronto, Ontario, Canada, 2689, (1995). |
J. S. Kim, et al., "Influence of steric factors on topoisomerase I inhibition and cytotoxicity of bisbenzimidazoles related to Hoechst 33342", Abstract 7, 3rd annual scientific retreat, Cancer Institute of New Jersey, Princeotn Marriott Forrestal Village, 28, (1995). |
J. S. Kim, et al., "Steric factors associated with the topoisomerase I inhibition and cytotoxicity of substituted bisbenzimidazoles", Abstract 10, American Assn of Pharmaceutical Scientists, Eastern Regional Meeting, 27, (1995). |
Jung Sun Kim, et al., "Structure-activity Relationships of Benzimidazoles and Related Heterocycles as Topoisomerase I Poisons", Bioorganic & Med. Chem., 4, 621-630, (1996). |
Jung Sun Kim, et al., "Substituted 2,5'-Bi-1H-benzimidazoles: Topoisomerase I Inhibition and Cytotoxicity", J. Med. Chem., 39, 992-998, (1996). |
E. J. LaVoie, et al., "Structure-activity studies related to minor groove-binding ligands which inhibit mammalian DNA topoisomerase I", Abstract 1, 85th Annual Meeting of American Association for Cancer Research, Apr. 10-13, 1994, San Francisco, CA, 269, (1994). |
Darshan Makhey, et al., "Coralyne and Related Compounds as Mammalian Topoisomerase I and Topoisomerase II Poisons", Bioorg. & Med. Chem. Lett., 4, 781-791, (1996). |
Darshan Makhey, et al., "Protoberberine Alkaloids and Related Compounds as Dual Inhibitors of Mammalian Topoisomerase I and II", Med. Chem. Res., 5, 1-12, (1994). |
Sanath K. Meegalla, et al., "Synthesis and Pharmacological Evaluation of Isoindolo�1,2-b!quinazolinone and Isoindolo�2,1-a!benzimidazole Derivatives Related to the Antitumor Agent Batracylin", J. Med. Chem., 37, 3434-3439, (1994). |
Daniel S. Pilch, et al., "Biophysical Characterization of a Cytotoxic, Topoisomerase I Poison", Abstract 8, 3rd annual Scientific Retreat, Cancer Institute of New Jersey, 3, (1995). |
B. A. Porai-Koshits, et al., "Imidazole derivatives Synthesis of some polybenzimidazoles", J. GEn. Chem. USSR, 23 as related in Chemical Abstracts, vol. 48, Nov. 10, 1954, Col. 12740, 873-9, (1953). |
B. A. Porai-Koshits, et al., "Imidazole derivatives. Synthesis of some polybenzimidazoles", Zhur. Obshchei Khim, 23, as related from Chemical Abstracts, vol. 48, Apr. 25, 1954, Col. 4523, 835-41, (1953). |
Qun Sun, et al., "Stucture-activity studies related to minor groove-binding ligands which inhibit mammalian DNA topoisomerase I", Cancer Institute of New Jersey, First Annual Scientific Retreat, Jun. 7, 1994, Princeton Marriott Forrestal Village, Princeton, New Jersey, 66, (1994). |
Qun Sun, et al., "Structure Activity of Topoisomerase I Poisons Related to Hoechst 33342", Bioorganic & Medicinal Chemistry Lettters, 4, 2871-2876 (1994). |
Qun Sun, et al., "Synthesis and Evaluation of Terbenzimidazoles as Topoisomerase I Inhibitors", J.Med. Chem., vol. 38, pp. 3638-3644, (1995). |
Qun Sun, et al., "Synthesis and pharmacological evaluation of a series of novel DNA topoisomerase I Inhibitors as antitumor agents", 86th Annual meeting of the American Association for Cancer Research, Toronto, Ontario, Canada, 2688, (1995). |
Qun Sun, et al., "Synthesis and pharmacological evaluation of a series of novel DNA topoisomerase I inhibitors as antitumor agents", Abstract 5, 3rd Annual Scientific Retreat, Cancer Institute of New Jersey, 27, (1995). |
Qun Sun, et al., "Structure activity of novel Topoisomerase I Inhibitors related to Hoechst 33342", Abstract 6, American Association of Pharmaceutical Scientists, Eastern Regional Meeting, Jun. 5-6, 1995. |
Qun Sun, et al., "Synthesis of Benzimidazo�2,1-a! isoquinolines and 5,6-Dihydrobenzimidazo�2,1-a! isoquinolines", SynLett, submitted, (1995). |