Claims
- 1. A compound selected from those of formula (I): ##STR28## in which: R represents hydrogen or a radical chosen from alkyl, substituted alkyl and --O--R'; with R' representing hydrogen or a radical selected from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, substituted cycloalkylalkyl, phenyl, substituted phenyl, phenylalkyl, substituted phenylalkyl, diphenylalkyl and substituted diphenylalkyl;
- R.sub.1 represents hydrogen or alkyl;
- R.sub.2 means a) ##STR29## in which X.sup.1 represents sulfur or oxygen and R.sub.40 represents hydrogen or a radical chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, substituted cycloalkylalkyl, alkenyl, substituted alkenyl, alkynyl and substituted alkynyl;
- or b) ##STR30## in which X.sup.2 represents sulfur or oxygen and R.sub.41 represents hydrogen or a radical chosen from alkyl, cycloalkyl and cycloalkylalkyl;
- R.sub.3 represents a radical chosen from:
- R.sub.5 -alkyl-, with R.sub.5 being substituted or unsubstituted and representing pyridyl,
- R.sub.6 --CO--O--,
- and R.sub.6 --CO--,
- with R.sub.6 representing a radical chosen from R.sub.5 - and R.sub.5 -alkyl- where R.sub.5, being unsubstituted or substituted, is as defined above,
- the terms "alkyl" and "alkoxy" inclusively denoting, except where otherwise mentioned, linear or branched groups of 1 to 6 carbon atoms,
- the terms "alkenyl" and "alkynyl" inclusively denoting unsaturated, linear or branched groups of 2 to 6 carbon atoms,
- the term "cycloalkyl" inclusively denoting a cyclic group of 3 to 8 carbon atoms,
- the term "substituted" applied to "alkyl", "alkoxy", "alkenyl", "alkynyl", "cycloalkyl" or "cycloalkylalkyl" means that these groups are substituted with one or more radicals chosen from alkyl, alkoxy and halogen;
- the term "substituted" associated with R.sub.5 and with "phenyl", "phenylalkyl" or "diphenylalkyl" means that these groups are substituted with one or more radicals chosen from alkyl, alkoxy, halogen, hydroxyl and trifluoromethyl;
- their enantiomers and diastereoisomers,
- and their addition salts with a pharmaceutically-acceptable acid or base.
- 2. A pharmaceutical composition useful in treating sleep disorders containing a compound of claim 1 in combination with one or more pharmaceutically-acceptable excipients.
- 3. A method of treating a mammal afflicted with a disorder of the melatoninergic system comprising the step of administrating to said mammal an effective amount of a compound according to claim 1 for alleviation of said disorder.
- 4. A method of treating a mammal afflicted with a sleeping disorder comprising the step of administering to the said mammal an effective amount of a compound according to claim 1 for alleviation of said disorder.
Priority Claims (1)
| Number |
Date |
Country |
Kind |
| 93.14630 |
Dec 1993 |
FRX |
|
Parent Case Info
The present application is a division of our prior-filed application Ser. No. 08/349,914, filed Dec. 6, 1994.
Foreign Referenced Citations (2)
| Number |
Date |
Country |
| 530087 |
Mar 1993 |
EPX |
| 3828566A1 |
Mar 1990 |
DEX |
Non-Patent Literature Citations (3)
| Entry |
| Yous et al., J. Med. Chem. 35(8), pp. 1484-1486 (1992). |
| Cas Abstract of published German Patent Application DE3828566, 1990. |
| Derwent Abstract of published German Patent Application DE3828566, 1990. |
Divisions (1)
|
Number |
Date |
Country |
| Parent |
349914 |
Dec 1994 |
|
Patent Grant
5552418
