Claims
- 1. A compound of the formula: ##STR5## R.sub.1 and R.sub.3 are aralkyl, R.sub.8 is alkyl or aralkyl, and R.sub.1, R.sub.3, and R.sub.8 are unsubstituted or substituted by a substituent selected from the group consisting of halogen, hydroxy, C.sub.1 -C.sub.4 alkoxy, C.sub.3 -C.sub.7 cycloalkoxy, oxo, oximido, carbamino, and hydroxycarbimido;
- R.sub.2 is selected from the group consisting of S and O, and R.sub.6 is selected from the group consisting of S and O, provided that R.sub.2 and R.sub.6 are not both O.
- 2. The compound according to claim 1, wherein R.sup.8 is cycloalkyl or branched alkyl.
- 3. The compound according to claim 1, wherein R.sub.8 is an alkyl selected from the group consisting of methyl, ethyl, isopropyl, n-propyl, cyclopropyl, butyl and pentyl and said alkyl being straight, branched or cyclic.
- 4. The compound according to claim 1, wherein R.sub.1, R.sub.3 and R.sub.8 are further substituted by a substituent selected from the group consisting of halogen, hydroxy, C.sub.1 -C.sub.4 alkoxy, C.sub.3 -C.sub.7 cycloalkoxy, and oxo.
- 5. The compound according to claim 1, wherein R.sup.8 is selected from the group consisting of straight chain alkyls and branched chain alkyls.
- 6. The compound according to claim 1, wherein R.sub.1 and R.sub.3 are benzyl, optionally substituted with halogen, hydroxy, C.sub.1 -C.sub.4 alkoxy, and C.sub.3 -C.sub.7 cycloalkoxy.
- 7. The compound according to claim 1 that is
- 1,3-Di-(4-chlorobenzyl)-8-isopropyl-6-thioxanthine.
- 8. A pharmaceutical composition comprising a compound according to claim 1, or a salt thereof, together with a pharmaceutically acceptable carrier.
- 9. The pharmaceutical composition according to claim 8 that is
- 1,3-Di-(4-chlorobenzyl)-8-isopropyl-6-thioxanthine.
- 10. The pharmaceutical composition according to claim 8 wherein said pharmaceutically acceptable carrier is suitable for administration by a method selected from the group consisting of orally, topically, by suppository, inhalation, insufflation, and parenterally.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a 371 of PCT/US95/16724, filed Dec. 12, 1995, which is a continuation-in-part of Application Ser. No. 08/476,262 filed Jun. 7, 1995 now abandoned, which is a continuation-in-part of Application Ser. No. 08/354,664 filed Dec. 13, 1994 now abandoned.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/US95/16724 |
12/12/1995 |
|
|
9/29/1997 |
9/29/1997 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO96/18400 |
6/20/1996 |
|
|
US Referenced Citations (84)
Foreign Referenced Citations (3)
Number |
Date |
Country |
994351 |
Aug 1976 |
CAX |
0178413 |
Apr 1986 |
EPX |
0203721 |
Dec 1986 |
EPX |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
476262 |
Jun 1995 |
|
Parent |
354664 |
Dec 1994 |
|