Claims
- 1. A method for treating a patient suffering from cancer comprising administering to said patient an effective amount of a trisubstituted triazine compound of the formula:
- 2. A method for interfering with microtubule assembly comprising administering to a patient in need thereof an effective amount of a trisubstituted triazine compound of the formula:
- 3. A compound according to the formula:
- 4. A compound according to the formula:
- 5. The compound according to claim 3 wherein X is N, O, or S;
R1 is 4-methoxybenzyl, 3,4-methoxybenzyl, 3,4,5-trimethoxybenzyl, 4-methoxyphenyl, 3,4-methoxyphenyl, 3,4,5-trimethoxyphenyl, or C1-C14 alkyl; R2 is C1-C20 alkyl or C3-C12 cyclic alkyl, is 4-methoxybenzyl, 3,4-methoxybenzyl, 3,4,5-trimethoxybenzyl, 4-methoxyphenyl, 3,4-methoxyphenyl, 3,4,5-trimethoxyphenyl, or substituted or unsubstituted heterocyclic; R3 is hydrogen or C1-C20 alkyl; R4 is C1-C20 alkyl, C3-C12 cyclic alkyl, 4-methoxybenzyl, 3,4-methoxybenzyl, 3,4,5-trimethoxybenzyl, 4-methoxyphenyl, 3,4-methoxyphenyl, 3,4,5-trimethoxyphenyl, or substituted or unsubstituted heterocyclic; and R5 is hydrogen or C1-C20 alkyl.
- 6. A method for treating a patient suffering from cancer comprising administering to said patient an effective amount of a trisubstituted triazine compound of the formula:
- 7. The method according to claim 5 wherein X is N, O, or S;
R1 is 4-methoxybenzyl, 3,4-methoxybenzyl, 3,4,5-trimethoxybenzyl, 4-methoxyphenyl, 3,4-methoxyphenyl, 3,4,5-trimethoxyphenyl, or C1-C20 alkyl; R2 is C1-C20 alkyl or C3-C20 cyclic alkyl, 4-methoxybenzyl, 3,4-methoxybenzyl, 3,4,5-trimethoxybenzyl, 4-methoxyphenyl, 3,4-methoxyphenyl, 3,4,5-trimethoxyphenyl, or substituted or unsubstituted heterocyclic; R3 is hydrogen or C1-C20 alkyl; R4 is C1-C20 alkyl, C3-C20 cyclic alkyl, is methoxybenzyl, 3,4-methoxybenzyl, 3,4,5-trimethoxybenzyl, 4-methoxyphenyl, 3,4-methoxyphenyl, 3,4,5-trimethoxyphenyl, or substituted or unsubstituted heterocyclic; and R5 is hydrogen or C1-C14 alkyl.
- 8. A method for interfering with microtubule assembly comprising administering to a patient in need thereof an effective amount of a trisubstituted triazine compound of the formula:
- 9. A method for interfering with microtubule assembly comprising administering to a patient in need thereof an effective amount of a trisubstituted triazine compound of the formula
- 10. The method according to claim 8, wherein X is N, O, or S;
R1 is 4-methoxybenzyl, 3,4-methoxybenzyl, 3,4,5-trimethoxybenzyl, 4-methoxyphenyl, 3,4-methoxyphenyl, 3,4,5-trimethoxyphenyl, or C1-C20 alkyl; R2 is C1-C20 alkyl or C3-C20 cyclic alkyl, 4-methoxybenzyl, 3,4-methoxybenzyl, 3,4,5-trimethoxybenzyl, 4-methoxyphenyl, 3,4-methoxyphenyl, 3,4,5-trimethoxyphenyl, or substituted or unsubstituted heterocyclic; R3 is hydrogen or C1-C20 alkyl; R4 is C1-C20 alkyl, C3-C20 cyclic alkyl, is methoxybenzyl, 3,4-methoxybenzyl, 3,4,5-trimethoxybenzyl, 4-methoxyphenyl, 3,4-methoxyphenyl, 3,4,5-trimethoxyphenyl, or substituted or unsubstituted heterocyclic; and R5 is hydrogen or C1-C14 alkyl.
- 11. A method for synthesizing trisubstituted triazines comprising:
a. loading a first amine onto a resin by reductive amination to form a first building block; b. adding a second amine to cyanuric chloride to form a second building block having a dichlorotriazine core structure; c. combining the first and second building blocks by aminating of the first building block onto one of the chloride positions of the second building block; and d. reacting a primary or secondary amine with the last chloride position to produce a trisubstituted triazine.
- 12. The method according to claim 11, wherein the tresubstituted triazines have the formula:
- 13. The method according to claim 10 wherein the tresubstituted triazines have the formula:
CROSS REFERENCE TO RELATED APPLICATION
[0001] The present application is a Continuation of prior application Ser. No. 10/267,043, filed Oct. 9, 2002, and claims priority from non-provisional application Serial No. 60/328,422, filed Oct. 12, 2001, the entire contents of which are hereby incorporated by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60328422 |
Oct 2001 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
10267043 |
Oct 2002 |
US |
Child |
10465815 |
Jun 2003 |
US |