Patent Application
20210301949
Systems including tubing such as bioprocessing systems, particularly single-use systems, typically utilize flexible tubing to provide fluid communication between various components and for connecting fluid processes. The systems can include a number of tubes and/or a variety of tubes having different inside and/or outside diameters.
The present invention provides for ameliorating at least some of the disadvantages of the prior art. These and other advantages of the present invention will be apparent from the description as set forth below.
An embodiment of the invention provides a tube retainer comprising a block comprising a top wall; a bottom wall; a first side wall; a second side wall; a third side wall; and a fourth side wall; a first opening comprising a tube slot having a first slot end and a second slot end, and a second opening having a generally annular shape, the first opening communicating with the second opening, the first and second openings passing through the top wall and the bottom wall; wherein at least the first side wall and the second side wall each include a male block connector comprising a first extending arm having a free end including a lug facing perpendicularly to the first extending arm and generally parallel to the respective side wall, and a second extending arm having a free end including a lug facing perpendicularly to the second extending arm and generally parallel to the respective side wall, wherein the lug on the first ending arm and the lug on the second extending arm face away from each other, the male block connector further comprising an extending tongue between the first extending arm and the second extending arm; and/or a female block connector comprising a recess comprising a first lug pocket having an open end and a closed end, and a second lug pocket having an open end and a closed end, wherein the first lug pocket and the second lug pocket are arranged generally parallel to the respective side wall and the open end of the first lug pocket faces the open end of the second lug pocket, the recess further comprising a central indentation between the first lug pocket and the second lug pocket; wherein the third wall or the fourth wall includes the first slot end of the tube slot.
In some embodiments of the tube retainer, the first side wall and the second side wall each include a male block connector and a female block connector.
Another embodiment of the invention provides a tube retainer set comprising at least first and second tube retainers.
Yet another embodiment of the invention relates to a tube retainer management system comprising at least one tube retainer, preferably, at least one tube retainer set, interlockable with a mounting bar.
In other embodiments, methods of assembling and using the tube retainers, tube retainer sets, and tubing retainer management systems, are provided.
A tube retainer according to an embodiment of the invention comprises a block comprising a top wall; a bottom wall; a first side wall; a second side wall; a third side wall; and a fourth side wall; a first opening comprising a tube slot having a first slot end and a second slot end, and a second opening having a generally annular shape, the first opening communicating with the second opening, the first and second openings passing through the top wall and the bottom wall; wherein at least the first side wall and the second side wall each include a male block connector comprising a first extending arm having a free end including a lug facing perpendicularly to the first extending arm and generally parallel to the respective side wall, and a second extending arm having a free end including a lug facing perpendicularly to the second extending arm and generally parallel to the respective side wall, wherein the lug on the first ending arm and the lug on the second extending arm face away from each other, the male block connector further comprising an extending tongue between the first extending arm and the second extending arm; and/or a female block connector comprising a recess comprising a first lug pocket having an open end and a closed end, and a second lug pocket having an open end and a closed end, wherein the first lug pocket and the second lug pocket are arranged generally parallel to the respective side wall and the open end of the first lug pocket faces the open end of the second lug pocket, the recess further comprising a central indentation between the first lug pocket and the second lug pocket; wherein the third wall or the fourth wall includes the first slot end of the tube slot.
A tube retainer according to another embodiment of the invention comprises a block comprising a top wall; a bottom wall; a first side wall; a second side wall; a third side wall; and a fourth side wall; a first opening comprising a tube slot having a first slot end and a second slot end, and a second opening having a generally annular shape, the first opening communicating with the second opening, the first and second openings passing through the top wall and the bottom wall; wherein at least the first side wall and the second side wall each include a male block connector comprising a first extending arm having a free end including a lug facing perpendicularly to the first extending arm and generally parallel to the side wall, and a second extending arm having a free end including a lug facing perpendicularly to the second extending arm and generally parallel to the side wall, wherein the lug on the first ending arm and the lug on the second extending arm face away from each other, the male block connector further comprising an extending tongue between the first extending arm and the second extending arm.
A tube retainer according to another embodiment of the invention comprises a block comprising a top wall; a bottom wall; a first side wall; a second side wall; a third side wall; and a fourth side wall; a first opening comprising a tube slot having a first slot end and a second slot end, and a second opening having a generally annular shape, the first opening communicating with the second opening, the first and second openings passing through the top wall and the bottom wall; wherein at least the first side wall and the second side wall each include a female block connector comprising a recess comprising a first lug pocket having an open end and a closed end, and a second lug pocket having an open end and a closed end, wherein the first lug pocket and the second lug pocket are arranged generally parallel to the side wall and the open end of the first lug pocket faces the open end of the second lug pocket, the recess further comprising a central indentation between the first lug pocket and the second lug pocket; wherein the third wall or the fourth wall includes the first slot end of the tube slot.
In some embodiments of the tube retainer, the first side wall and the second side wall each include a male block connector and a female block connector.
A tube retainer according to yet another embodiment of the invention comprises a block comprising a top wall; a bottom wall; a first side wall; a second side wall; a third side wall; and a fourth side wall; a first opening comprising a tube slot having a first slot end and a second slot end, and a second opening having a generally annular shape, the first opening communicating with the second opening, the first and second openings passing through the top wall and the bottom wall; wherein at least the first side wall and the second side wall each include a male block connector comprising a first extending arm having a free end including a lug facing perpendicularly to the first extending arm and generally parallel to the side wall, and a second extending arm having a free end including a lug facing perpendicularly to the second extending arm and generally parallel to the side wall, wherein the lug on the first ending arm and the lug on the second extending arm face away from each other, the male block connector further comprising an extending tongue between the first extending arm and the second extending arm; and, a female block connector comprising a recess comprising a first lug pocket having an open end and a closed end, and a second lug pocket having an open end and a closed end, wherein the first lug pocket and the second lug pocket are arranged generally parallel to the side wall and the open end of the first lug pocket faces the open end of the second lug pocket, the recess further comprising a central indentation between the first lug pocket and the second lug pocket; wherein the third wall or the fourth wall includes the first slot end of the tube slot.
Another embodiment of the invention provides a tube retainer set comprising at least first and second tube retainers.
Yet another embodiment of the invention relates to a tube retainer management system comprising at least one tube retainer, preferably, at least one tube retainer set, and a mounting bar, wherein the at least one tube retainer, or the at least one tube retainer set, is interlockable with the mounting bar.
An embodiment of a tube retainer management system comprises at least one tube retainer according to an embodiment of the invention and/or at least one tube retainer set according to an embodiment of the invention; and, a mounting bar for the at least one tube retainer and/or the at least one tube retainer set, the mounting bar comprising a front wall and at least two female block connectors, each female block connector comprising a recess comprising a first lug pocket having an open end and a closed end, and a second lug pocket having an open end and a closed end, wherein the first lug pocket and the second lug pocket are arranged generally parallel to the front wall and the open end of the first lug pocket faces the open end of the second lug pocket, the recess further comprising a central indentation between the first lug pocket and the second lug pocket.
In other embodiments, methods of using the tube retainers, the tube retainer sets, and the tubing retainer management systems are provided.
In an embodiment, a method of assembling tube retainers is provided, the method comprising interlocking a first tube retainer including a top wall; a bottom wall; a first side wall; a second side wall; a third side wall; and a fourth side wall; a first opening comprising a tube slot having a first slot end and a second slot end, and a second opening having a generally annular shape, the first opening communicating with the second opening, the first and second openings passing through the top wall and the bottom wall; the first tube retainer comprising at least one male block connector comprising a first extending arm having a free end including a lug facing perpendicularly to the first extending arm and generally parallel to the side wall, and a second extending arm having a free end including a lug facing perpendicularly to the second extending arm and generally parallel to the side wall, wherein the lug on the first ending arm and the lug on the second extending arm face away from each other, the male block connector further comprising an extending tongue between the first extending arm and the second extending arm with a second tube retainer with a second tube retainer including a top wall; a bottom wall; a first side wall; a second side wall; a third side wall; and a fourth side wall; a first opening comprising a tube slot having a first slot end and a second slot end, and a second opening having a generally annular shape, the first opening communicating with the second opening, the first and second openings passing through the top wall and the bottom wall; the second tube retainer comprising at least one female block connector comprising a recess comprising a first lug pocket having an open end and a closed end, and a second lug pocket having an open end and a closed end, wherein the first lug pocket and the second lug pocket are arranged generally parallel to the side wall and the open end of the first lug pocket faces the open end of the second lug pocket, the recess further comprising a central indentation between the first lug pocket and the second lug pocket; wherein the third wall or the fourth wall includes the first slot end of the tube slot such that the lugs of the first and second extending arms of the at least one male connector of the first tube retainer are engaged in the first and second lug pockets of the at least one female connector of the second tube retainer.
In a typical embodiment, the method further comprises passing a tube through the tube slot and into the second opening of the first or second tube retainer, preferably the method further comprises passing a first tube through the tube slot and into the second opening of the first tube retainer, and passing a second tube through the tube slot and into the second opening of the second tube retainer.
Advantageously, multiple tubes and/or tubes of different diameters can be safely secured in the tube retainers, tube retainer sets, and tube retainer management system, thus reducing the change of tangling, getting snagged on system components, accidental disassembly, and/or being tripped over. Additionally, tubing can be safely secured without damaging the tubing, and changes in the design of the bioprocessing system and/or temporary hardware in the bioprocessing system can be easily accommodated. The compact design of the tube retainers, tube retainer sets, and tube management system minimizes complexity and size.
Embodiments of the invention can be utilized with any diameter tubing. While conventional tubing outside diameters are (in inches) ⅛, ¼, 5/16, ⅜, ½, ⅝, ¾, 1, and 1.5, other tubing diameters can also be used. Typically, embodiments of tube retainers as shown in
As used herein, systems including tubing include, for example, bioprocessing systems including fluid transfer lines such as bioreactor systems, buffer management systems, and filtration systems (e.g., involving tangential flow filtration, depth filtration, and/or polishing).
Each of the components of the invention will now be described in more detail below, wherein like components have like reference numbers.
At least one side wall of tube retainer 100 (preferably, at least two side walls), comprises a male block connector 180 comprising a first extending arm 181 having a free end 181A including a lug 181B facing perpendicularly to the first extending arm and generally parallel to the side wall, and a second extending arm 182 having a free end 182A including a lug 182B facing perpendicularly to the second extending arm and generally parallel to the side wall, wherein the lug on the first ending arm and the lug on the second extending arm face away from each other, the male block connector further comprising an extending tongue 183 between the first extending arm and the second extending arm.
In the embodiment illustrated in
At least one side wall of tube retainer 100 (preferably, at least two side walls), comprises a female block connector 190/190′ comprising a recess 191 comprising a first lug pocket 192 having an open end 192A and a closed end 192B, and a second lug pocket 193 having an open end 193A and a closed end 193B, wherein the first lug pocket and the second lug pocket are arranged generally parallel to the side wall and the open end 192A of the first lug pocket faces the open end 193A of the second lug pocket. In some embodiments, the recess of at least one female connector 190 further comprises a central indentation 194 between the first lug pocket and the second lug pocket. In other embodiments, at least one female connector 190′ lacks the central indentation as the side wall including the female connector includes the first slot end 151A of the tube slot.
In the embodiment illustrated in
At least one side wall of tube retainer 200 (preferably, at least two side walls), comprises (in addition to a female block connector as discussed below) a male block connector 280 comprising a first extending arm 281 having a free end 281A including a lug 281B facing perpendicularly to the first extending arm and generally parallel to the side wall, and a second extending arm 282 having a free end 182A including a lug 282B facing perpendicularly to the second extending arm and generally parallel to the side wall, wherein the lug on the first ending arm and the lug on the second extending arm face away from each other, the male block connector further comprising an extending tongue 283 between the first extending arm and the second extending arm.
In the embodiment illustrated in
At least one side wall of tube retainer 200 (preferably, at least two side walls), comprises (in addition to the male block connector as discussed above) a female block connector 290 comprising a recess 291 comprising a first lug pocket 292 having an open end 292A and a closed end 292B, and a second lug pocket 293 having an open end 293A and a closed end 293B, wherein the first lug pocket and the second lug pocket are arranged generally parallel to the side wall and the open end 292A of the first lug pocket faces the open end 293A of the second lug pocket, and wherein the recess further comprises a central indentation 294 between the first lug pocket and the second lug pocket.
In the illustrated embodiments, at least one female block connector 290′ comprises a recess 291 comprising a first lug pocket 292 having an open end 292A and a closed end 292B, wherein the first lug pocket is arranged generally parallel to the side wall, and wherein the recess further comprises a central indentation 294 near the first lug pocket. However, the illustrated female block connector 290′ lacks one lug pocket as the side wall including the female connector 290′ includes the first slot end 151A of the tube slot.
In the embodiment illustrated in
Tubing is inserted in a tube retainer by passing it through the tubing slot into the second opening which has a generally annular shape. The tubing is compressed as it passes through the slot, and expands to its regular diameter once located in the second opening. If desired, the first end of the tube slot can be closed by interlocking the tube retainer with a second tube retainer such that an extending tongue of the male connector of the second tube retainer fits in the first end of the tube slot of the first tube retainer (see, for example,
Typically, a plurality of tube retainers are utilized at one time, thus providing a tube retainer set. Tube retainers can typically be slid, pushed and/or snapped together, such that the male block connector(s) engage and interlock with the corresponding female block connector(s).
A tube retainer set can comprise two or more embodiments of tube retainers as illustrated in
Illustratively,
With respect to interlocking, as shown in
In some configurations, some of the extending tongues of the male connectors of the tube retainers fit into the first ends of tube slots (see, for example, the interlocking of tube retainer 100B and tube retainer 200A in
Typically, tube retainers and tube retainer sets are utilized with a mounting bar.
As noted above, embodiments of the invention can be used with a variety of bioprocessing systems. Typically, tube retainers and tube retainer sets are utilized with a mounting bar that can be configured for attachment to a bioprocessing system before or after connection with interlocking tube retainers/tube retainer sets. For example, the mounting bar can include one or more cut outs to allow hanging on an extending pin or screw, or flanges to allow mounting. The embodiment illustrated in
In accordance with another embodiment of the invention, a tube management system is provided comprising a mounting bar and at least one tube retainer and/or tube retainer set.
For example,
In accordance with embodiments of methods of retaining tubes according to the invention, embodiments of tube retainers and/or tube retainer sets can be interconnected and/or embodiments of the tube management systems can be assembled and tubes can be subsequently placed in the interlocking tube retainers and/or tube retainer sets, or tubes can be placed in interlocking tube retainers that are already interconnected with each other and/or with a mounting bar.
All references, including publications, patent applications, and patents, cited herein are hereby incorporated by reference to the same extent as if each reference were individually and specifically indicated to be incorporated by reference and were set forth in its entirety herein.
The use of the terms “a” and “an” and “the” and “at least one” and similar referents in the context of describing the invention (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. The use of the term “at least one” followed by a list of one or more items (for example, “at least one of A and B”) is to be construed to mean one item selected from the listed items (A or B) or any combination of two or more of the listed items (A and B), unless otherwise indicated herein or clearly contradicted by context. The terms “comprising,” “having,” “including,” and “containing” are to be construed as open-ended terms (i.e., meaning “including, but not limited to,”) unless otherwise noted. Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., “such as”) provided herein, is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention unless otherwise claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the invention.
Preferred embodiments of this invention are described herein, including the best mode known to the inventors for carrying out the invention. Variations of those preferred embodiments may become apparent to those of ordinary skill in the art upon reading the foregoing description. The inventors expect skilled artisans to employ such variations as appropriate, and the inventors intend for the invention to be practiced otherwise than as specifically described herein. Accordingly, this invention includes all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law. Moreover, any combination of the above-described elements in all possible variations thereof is encompassed by the invention unless otherwise indicated herein or otherwise clearly contradicted by context.
