Claims
- 1. An isolated polynucleotide comprising a nucleotide sequence according to SEQ ID NO:1.
- 2. The polynucleotide of claim 1 wherein the nucleotide sequence comprises a leader sequence domain, a transmembrane domain, and a carbohydrate recognition domain, and wherein at least one of the leader sequence domain, the transmembrane domain, and the carbohydrate recognition domain is deleted at least in part.
- 3. The polynucleotide of claim 2 having a sequence selected from the group consisting of SEQ ID NO:2 and SEQ ID NO:3.
- 4. The polynucleotide of claim 2 having a sequence according to SEQ ID NO:2.
- 5. The polynucleotide of claim 2 having a sequence according to SEQ ID NO:3
- 6. A vector comprising the nucleotide sequence of claim 1, wherein the nucleotide sequence is operationally coupled to a control sequence that is recognized by a host cell transformed with the vector.
- 7. A vector comprising the nucleotide sequence of claim 3, wherein the nucleotide sequence is operationally coupled to a control sequence that is recognized by a host cell transformed with the vector.
- 8. A host cell transformed with the vector of claim 6.
- 9. A host cell transformed with the vector of claim 7.
- 10. An isolated polypeptide having an amino acid sequence according to SEQ ID NO 4.
- 11. An isolated polypeptide having an amino acid sequence according to a sequence selected from the group consisting of SEQ ID NO 5 and SEQ ID NO 6.
- 12. The isolated polypeptide of claim 10 wherein the isolated polypeptide is coupled to a non-type-C lectin polypeptide.
- 13. The isolated polypeptide of claim 10 wherein the isolated polypeptide is coupled to at least a portion of an immunoglobulin.
- 14. The isolated polypeptide of claim 13 wherein the portion of the immunoglobulin comprises a constant part of a heavy chain of an immunoglobulin G.
- 15. The isolated polypeptide of claim 11 wherein the isolated polypeptide is coupled to a non-type-C lectin polypeptide.
- 16. The isolated polypeptide of claim 15 wherein the isolated polypeptide is coupled to at least a portion of an immunoglobulin.
- 17. A method of regulating the uptake of a drug into a cell, comprising:
correlating the uptake of the drug with a presence of a type-C lectin on a surface of the cell; transforming the cell with a nucleic acid, wherein the nucleic acid encodes the type-C lectin, and wherein the nucleic acid is transcribed within the cell to produce a transcript; and wherein the transcript at least indirectly alters an amount of the type-C lectin on the surface of the cell.
- 18. The method of claim 17 wherein the cell is a neoplastic cell, and the step of transforming comprises receptor-mediated uptake of the nucleic acid.
- 19. The method of claim 17 wherein the transcript is translated, thereby increasing the amount of the type-C lectin on the surface of the cell.
- 20. The method of claim 17 wherein the transcript hybridizes with a cellular nucleic acid encoding the type-C lectin, thereby decreasing the amount of the type-C lectin on the surface of the cell.
Parent Case Info
[0001] This application claims the benefit of U.S. provisional application No. 60/351,501, which was filed Jan. 23, 2002, and which is incorporated herein by reference.
Provisional Applications (1)
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Number |
Date |
Country |
|
60351501 |
Jan 2002 |
US |