The present invention relates to a medical ultrasonic imaging device, and particularly to a technique of high image quality by improving a signal to noise ratio.
An ultrasonic diagnosing device has been widely used as a medical cross-sectional image imaging device due to characteristics such as real-time properties and portability. The ultrasonic diagnosing device has been absolutely essential as a medical image diagnosing device in a method of detecting, especially, lesions of tumors of soft tissue such as body surface tissue such as the mammary gland or thyroid gland, digestive organs such as the liver or kidney, and circulatory organs such as the heart or vascular channels. A spatial resolution and an imaging depth that are fundamental indexes of performance in the ultrasonic diagnosing device have a trade-off relation. Specifically, if the frequency is raised, the wavelength is shortened. If the fractional bandwidth (=center frequency/bandwidth) is constant, the spatial resolution is improved. On the other hand, the attenuation rate along with ultrasonic propagation in a living body is increased as the frequency becomes higher. Namely, the higher the frequency is, the more the signal strength at a position far from an ultrasound probe is extremely attenuated. Ultrasonic energy attenuated in a living body is changed to heat, and thus there is a possible risk that the living body is damaged by applying an excessive acoustic pressure. Further, if a temporal peak pressure becomes large, the risk of cavitation is possibly increased. In order to minimize the risk of damage of the living body, the acoustic pressure or energy of ultrasonic waves transmittable to the living body is restricted. Thus, in the case where echoes from a deep area are reduced as a result of tissue attenuation, there is no method to restore. In a normal diagnosing device, after an echo signal is received and amplified by a preamplifier, analog to digital conversion is performed. Thus, every diagnosing device has a finite dynamic range due to the finite bit width of analog to digital conversion. Further, under the influence of random electric noise after analog to digital conversion, the fact is that the dynamic range of analog to digital conversion cannot be fully used in general. Therefore, in the case where echoes from a tissue deep area are reduced due to tissue attenuation, the signal to noise ratio is decreased, resulting in deterioration in the sensitivity and resolution of an image. If the frequency is lowered to compensate this, the spatial resolution is disadvantageously decreased. As a method of compensating such decrease in the signal to noise ratio, there is a method as disclosed in Patent Literature 1 in which after analog to digital conversion and delay processes, a bandpass filter on a frequency space is inserted to improve the signal to noise ratio.
Patent Literature 1: Japanese Patent Application Laid-Open Publication No. H11-244286
A bandpass filter on a frequency axis is one method contributing to compatibility between a spatial resolution and an imaging depth (penetration). However, in order to significantly improve the signal to noise ratio with this method, it is necessary to narrow the bandwidth of the bandpass filter and there is a possibility to lead to a decrease in the spatial resolution. Namely, this means being not free from the trade-off between the spatial resolution and the imaging depth. An object of the present invention is to realize compatibility between the spatial resolution and the imaging depth of an ultrasonic diagnosing device using other means.
In order to achieve the above-described object, the present invention provides an ultrasonic diagnosing device including: an array element; a transmitter that transmits ultrasonic waves to a target through the array element; a receiver that delays and sums a reception wave signal received by the array element from the target; a display that displays a cross-sectional image of the target from the reception wave signal output from the receiver; and a controller that controls the transmitter and the receiver, wherein the receiver includes an inter-channel filter that selectively suppresses electric noise, a receiving beamformer that selectively receives a beam, and an envelope detection unit, and the inter-channel filter performs a filtering process in which a signal and noise contained in an echo signal from the target are separated from each other using continuity between channels to remove the noise.
Specifically, according to the present invention, filtering between channels or two-dimensional filtering between channels and in a temporal axis is performed after analog to digital conversion, so that a signal to noise ratio can be improved while minimizing a decrease in the spatial resolution.
According to the aspects of the present invention, compatibility between a spatial resolution and a signal to noise ratio that are two fundamental performances of an ultrasonic diagnosing device is achieved, and an improvement in the quality of a cross-sectional image is realized as a result.
Hereinafter, modes for carrying out the present invention will be described based on the drawings.
An ultrasonic diagnosing device according to a first embodiment includes an array element 1, a transmitter that transmits ultrasonic waves to a target through the array element, a receiver that delays and sums a reception wave signal received by the array element from the target, a display 14 that displays a cross-sectional image of the target from the reception wave signal output from the receiver, and a controller 6 that controls the transmitter and the receiver. The receiver includes an inter-channel filter 9 that selectively suppresses electric noise, a receiving beamformer 10 that selectively receives a beam, and an envelope detection unit 11. The inter-channel filter 9 performs a filtering process in which a signal and noise contained in an echo signal from the target are separated from each other using continuity between channels to remove the noise.
In the first place, a flow of signal processing for imaging in the ultrasonic diagnosing device of the embodiment will be described using
A part of the ultrasonic pulse scattered in the target is received by the array element 1 again as an echo signal to be converted from the ultrasonic signal into an electric signal. The received signal is drawn in the receiver through the transmission/reception switch 2. In the receiver configured using circuit blocks to a bandpass filter 12 from a TGC amplifier 7 into which the received electric signal from the transmission/reception switch 2 is input, the signal is first amplified by the time gain control (TGC) amplifier 7 in accordance with the propagation distance of echoes to convert an analog signal to a digital signal with an analog/digital (A/D) conversion element 8, and a signal to noise ratio is improved by the inter-channel filter 9 as a characteristic of the present invention. In addition, a delay and sum process is performed by the receiving beamformer (BF) 10 for the signal as data on a scan line obtained by selectively intensifying an echo signal from a desired depth on a desired scan line. The data for which the delay and sum process was performed is converted into an envelope signal by the envelope detection unit 11 to be transmitted to a scan convertor 13 through the bandpass filter 12, and scan conversion is performed. Data obtained after the scan conversion is transmitted to the display 14, and is displayed as an ultrasonic cross-sectional image. The receiver of the ultrasonic diagnosing device in the embodiment includes at least the inter-channel filter 9 that selectively suppresses electric noise, the receiving beamformer 10 that selectively receives a beam, and the envelope detection unit 11. For reference, an example of a configuration of a conventional device is shown in
Next, the concept of the present invention will be described. An object to be separated and removed in the present invention is electric noise that is mixed in the course from the time an ultrasonic signal is converted into an electric signal by the array element 1 to the time the delay and sum process is performed by the receiving beamformer 10.
As shown in
Next, effects of the present invention were quantitatively estimated by a real calculation simulation. The parameters used in the calculation were as follows: number of elements (number of channels), 64; center frequency, 7.5 MHz; pitches of elements, 0.2 mm; number of cycles of transmission waveforms, 2; focal distance, 50 mm; sampling time of simulation, 1/32 of cycle; acoustic velocity, 1540 m/s; intervals of scatterers: 1/16 of wavelength; and space where the scatterer was placed, 1×1 mm. Under the conditions, the echo signals from random scatterers were received by each element, and the transfer function and convolution of the array element were performed to be converted into waveforms on the temporal axis. In this case, the space of the scatterer was assumed to be in the focal area of the transmission beam. After being converted into waveforms on the temporal axis, electric noise was randomly added to perform a delay process between the elements, and the inter-channel filtering of the present invention was performed. After the filtering, an adding process between channels was performed. The scatterer existed in one half of the space of the scatterer and no scatterer existed in the other half thereof. Accordingly, the signal to noise ratio was evaluated. It should be noted that the simulation was performed so that an area without signals was a finite dynamic range in which the bit width of the analog to digital conversion was 16 bits.
a) shows echo data on the temporal axis after the delay and sum process in the case where no noise was mixed. No signals exist in an area where the number of sampling points is 60 or smaller, and signals exist in an area where the number of sampling points is 70 or larger. The average value of the noise strength was subtracted from the average value of the signal strength to evaluate the signal to noise ratio.
As a filter between channels, the median filter has been described above as an example. The concept of the present invention is a method in which a signal without continuity is separated and removed through a signal with continuity between channels. In the viewpoint, a bandpass filter related to spatial frequencies can be used other than the median filter. The delay and sum process originally functions as a low-pass filter in the spatial method, and thus there is no difference.
On the other hand, a filter that adaptively functions to the characteristics of a signal can be also used. For example, a weight-variable adaptive filter described below using each of
I
0
′=Σw
ij
×I
ij
/ΣI
ij Equation 1
Σ: adding in a range from i and j (each starting from 1) to imax and jmax.
Next, the weighting function will be described. As a function by which a weight is monotonically decreased as the difference between I0 and Iij becomes larger, the Gaussian function or an even-ordered polynomial equation can be used. The computing process of Equation 1 is performed using the weighting function, so that only the noise components can be suppressed without deteriorating the spatial resolution. An example of the weight-variable adaptive filter has been described above. However, if a morphological filter (a filter to calculate the maximum or minimum value with a shape weight added), a spike removal filter, or a ripple removal filter is used, the similar effects can be expected.
Further, in the case where the present invention is applied to the ultrasonic diagnosing device, it is effective to dynamically change the shape (the size of the median filter in the azimuth direction or the cutoff frequency of the spatial frequency in the azimuth direction) of the inter-channel filter in accordance with the depth of the echo signal source. Because an aperture width is normally constant except a close range in the ultrasonic diagnosing device. Thus, as the depth becomes deeper, a ratio of the focal distance to the aperture width becomes large and the beam width in the azimuth direction is widened. Further, the frequencies are cut from the high-frequency components due to the living body-dependent attenuation. Thus, echoes from a deeper position contain more low-frequency components, contributing to widening of the beam width. If it is assumed that each sampling point is in focus by the dynamic focus in consideration of reception wave beams, for example, a diffraction angle θ can be approximated by Equation 2 in the case of continuous waves in which the aperture width is W, the focal distance is L, the frequency is f, and the acoustic velocity of a living body is v.
θ=sin−1(v/2fw) Equation 2
The beam width at the reception wave focal point is L×tan θ. Thus, the beam width is in proportion to L and is in inverse proportion to f under the conditions where θ is small (the aperture is sufficiently wide relative to the wavelength). As a result, the coherence distance between channels becomes longer at a deeper position, and the optimum filter size accordingly becomes large. If the change is employed, noise can be optimally removed at each depth.
In the above study, selection of an acoustic signal and electric noise has been described. Using the method of the present invention, it is possible to discriminate a signal from the reception wave focal point from a signal (hereinafter, referred to as acoustic noise) from a position other than the reception wave focal point among the acoustic signals. In the reception wave beamforming, there are three kinds of signals as follows, as the acoustic signals from a point other than the reception wave focal point: (1) echo signals from a reflection source on a transmission and reception wave grating beam; (2) acoustic noise generated in such a manner that the echo signals from a point other than the reception wave focal point are received at the same timing as the arrival time of those from the focal point due to refraction or scattering during propagation; and (3) acoustic noise generated in such a manner that the echo signals from a point other than the reception wave focal point are received at the same timing as the arrival time of those from the focal point due to multiple reflection between the ultrasound probe and reflection objects in a living body. Among these, it is difficult to discriminate the signal (1) due to coherence with the signal from the reception wave focal point. On the other hand, for the signals (2) and (3), the distribution of reception times in each channel is different from that for signals from the reception wave focal point. When focusing on the difference between the characteristics, the acoustic noise caused by (2) and (3) can be reduced by applying the present invention. In the example of
In the first embodiment, there has been described an example of applying the method of removing electric noise to an ultrasonic cross-sectional image. In the embodiment, there will be described a case in which the present invention is applied to a Doppler blood flow measurement (a continuous wave Doppler measurement method and a pulse Doppler measurement method).
In the first place, there will be described a case in which the present invention is applied to the continuous wave Doppler measurement method. The continuous wave Doppler measurement method is a method in which while the azimuth direction where a reception wave beam is obtained is fixed, the frequency conversion of received data is performed by a method such as FFT and the speed of an echo source is estimated using effects of a Doppler shift by echo signals due to blood flow in accordance with the blood flow rate. As shown in
Next, there will be described a case in which the present invention is applied to the pulse Doppler measurement method. Unlike the continuous wave Doppler measurement method, the frequency conversion is not performed in the temporal axis direction of echoes but is performed in a repetition data obtaining method in the pulse Doppler measurement method. In the case where the inter-channel filtering is performed only in the azimuth direction, the processes between the analog to digital conversion and the receiving beamformer are the same as described above.
On the other hand, in the case where the analogy in which the two-dimensional median filter described in the first embodiment is applied in the channel direction and the temporal direction is applied to the pulse Doppler measurement method, coordinate axes are different from each other in the temporal direction.
The two-dimensional median filter in the ultrasonic wave transmission/reception repetition direction and the channel direction or the three-dimensional median filter in the ultrasonic wave transmission/reception repetition direction, the channel direction, and the temporal axis of echoes shown in
With the recent improvement in the performance of processors, an algorithm available as signal processing in an ultrasonic diagnosing device has been advanced. Especially, as a method of improving the resolution in the azimuth direction that has been regarded as a disadvantage in ultrasonic imaging from the past, the Capon method that has been developed in the fields of radar and mobile communications has been known. While a predetermined value has been used for a delay time irrespective of a reception signal in a conventional delay circuit, the Capon method is a method designed so that the delay time is optimized for each target reception data to realize the optimum resolution in the azimuth direction.
Specifically, the Capon method is a method of beamforming to optimize w so as to minimize the sum P=½ wRwt of the product of given two channels calculated using a correlation matrix R=VtV and a complex weight vector w to each channel while time-series data of each channel is represented as a vector V [v1 to vN] (N represents the number of channels and each v represents time-series data). The symbol with t in the upper right represents a transposed vector. When P is the smallest without constraint conditions, w=0. Thus, in order to make the beam output on the center axis other than 0, wat is set at 1 in the constraint conditions. In this case, “a” represents a mode vector that is composed of values obtained by adjusting differences between channel distances relative to the beam scanning direction to phase differences. “w” can be obtained by a variation method using w=R−1at/(aR−1at) at the time, the mode vector, the reciprocal of a correlation matrix. As preprocessing of the Capon beamforming, removing of incoherent noise of the present invention is advantageous. This is because the robustness of the Capon beamforming is improved.
As a method of improving the signal to noise ratio, there is a coded excitation method. It is necessary to restrict the maximum value of ultrasonic strength in consideration of impacts on a living body. In order to increase energy to be transmitted under the restrictions, there has been used the coded excitation method spread in the field of radar in which a coded signal extended in the temporal axis direction is transmitted, a signal reflected in a target is received to be converted into an electric signal, and the electric signal is then compressed in the temporal axis direction by a filtering process to be restored to a pulse waveform.
In the case of the coded excitation method, a drive coded pulse extended in the temporal axis direction is used. When an ultrasound probe is driven with the drive coded pulse, an ultrasonic signal with a coded waveform is transmitted from the ultrasound probe to the inside of a living body, and is returned after being reflected by a reflector in the living body. If the ultrasonic signal is converted into an electric signal again using the ultrasound probe, a coded reception waveform can be obtained. The coded waveform is shortened on the temporal axis by the extended length of the drive signal using a decoding filter adapted to the drive coded pulse. As a result, a decoded waveform with large signal strength can be obtained with the same distance resolution as the case of pulse transmission/reception. As described above, transmission wave energy can be increased without enlarging the amplitude in the living body. It is effective to combine the method and the inter-channel filter process of the present invention. Making the coded waveform as long as possible has a great effect on the signal to noise ratio in the coded excitation method. However, if it becomes extremely long, the length of the waveform exceeds the reception wave dynamic focus area, resulting in failure in decoding the codes. Therefore, it is desirable to decode the codes prior to the delay and sum process for the reception wave so as not to be affected by the reception wave dynamic focus. In the case where the present invention is applied to the coded excitation method, the position of the inter-channel filter inserted is important. This is because a difference in coherence between channels occurs even in the state of the coded waveform. Accordingly, the order of the analog to digital conversion of reception, the inter-channel filter, decoding the codes, and the delay and sum process is only a solution in the present invention.
The present invention has been described above using typical examples. However, it is obvious that the present invention can be realized within a range where the technological concept of the present invention is not changed even if the element technique is changed.
1 . . . array element, 2 . . . transmission/reception switch, 3 . . . transmission wave amplifier, 4 . . . transmission beamformer, 5 . . . waveform memory, 6 . . . controller, 7 . . . time gain control amplifier, 8 . . . analog to digital conversion element, 9 . . . inter-channel filter, 10 . . . receiving beamformer, 11 . . . envelope detection, 12 . . . bandpass filter, 13 . . . scan convertor, 14 . . . display, 15 . . . delay unit, 16 . . . adding unit
Number | Date | Country | Kind |
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2010-160205 | Jul 2010 | JP | national |
Filing Document | Filing Date | Country | Kind | 371c Date |
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PCT/JP2011/066220 | 7/15/2011 | WO | 00 | 1/4/2013 |