Patent Application
20190104945
The present invention relates to an ultrasonic probe suitable for use in an inspection utilizing a photoacoustic effect, and also relates to an inspection apparatus equipped with the ultrasonic probe.
An inspection apparatus capable of obtaining a tomographic image or a three-dimensional image of a sample by utilizing a photoacoustic effect is proposed, for example, as described in U.S. Pat. No. 4,385,634. Such a technique is generally known as PhotoAcoustic Tomography and is called a “PAT technique”.
A process of taking an image by the PAT technique is performed as follows:
Thus, the PAT technique has been so far studied primarily by research institutes in view of advantages resulting from the fact that the technique is based on comparatively simple processing, and that components such as a light source and an ultrasonic probe, which are already used for other purposes, can be employed as they are. In particular, an application to a biological information inspection apparatus for obtaining a high-resolution tomographic image is expected.
However, the PAT technique has the problem that, despite a demand for irradiating light to an inspection target from a position as close as possible to the target, the ultrasonic probe serving as a receiving unit impedes satisfaction of the demand by itself.
To overcome this problem, U.S. Patent Application Publication No. 2005/0004458 proposes an ultrasonic probe 1100 shown in
In
Because the ultrasonic probe 1100 proposed in U.S. Patent Application Publication No. 2005/0004458 includes light irradiating regions each formed between ultrasonic receiving regions, an effect of the shade of the ultrasonic probe 1100 can be reduced in comparison with the case of irradiating the light from a position around the ultrasonic probe 1100.
Even with the ultrasonic probe proposed in U.S. Patent Application Publication No. 2005/0004458, however, since the ultrasonic receiving regions and the light irradiating regions are disposed at different positions, a further improvement of sensitivity is demanded, for example, when observing capillary vessels that are positioned in the shallowest portion under the skin of a living body. Also, when the ultrasonic probe having the structure of
The present invention provides a novel ultrasonic probe which is optimum for taking an image of the internal structure of an inspection target by utilizing a photoacoustic effect, and also provides an inspection apparatus employing the ultrasonic probe.
The ultrasonic probe includes a light irradiating portion configured to radiate light for generating ultrasonic waves from a light absorber, an ultrasonic transducing portion configured to transduce the ultrasonic waves to an electric signal, and a light guide member configured to introduce the light from a light source to the light irradiating portion. A light irradiating region of the light irradiating portion is included within an ultrasonic receiving region of the ultrasonic transducing portion.
According to the present invention, a novel ultrasonic probe can be obtained which is optimum for taking an image of the internal structure of an inspection target by utilizing a photoacoustic effect, and an inspection apparatus employing the ultrasonic probe can also be obtained.
Further features of the present invention will become apparent from the following description of exemplary embodiments with reference to the attached drawings.
The basic concept of the ultrasonic probe according to exemplary embodiments of the present invention will be described with reference to
In the ultrasonic receiving surface 1302, the ultrasonic transducing portions 1301 have respective ultrasonic receiving regions 1303 with reception sensitivity. Numeral 1304 denotes each of individual light irradiating portions. The light irradiating portions 1304 are arranged in front of the ultrasonic receiving surface 1302 and have light irradiating regions from which light is irradiated toward an inspection target 1306.
The light irradiating portions 1304 can be arranged over the entire ultrasonic receiving surface 1302 on condition that the ultrasonic receiving regions 1303 include the light irradiating portions 1304. In other words, it is just required that the light irradiating regions are included within the ultrasonic receiving regions 1303. From the viewpoint of light utilization efficiency, however, the ultrasonic receiving regions 1303 and the light irradiating regions are preferably arranged to face each other, as shown in
If there is a light absorber 1307 in an inspection target 1306, light 1305 radiated from the light irradiating portions 1304 toward the inspection target 1306 is absorbed by the light absorber 1307 so that the light absorber 1307 is heated and radiates strong photoacoustic waves 1308 which are received by the ultrasonic transducing portions 1301.
Since the light is radiated from an area positioned just in front of the ultrasonic receiving regions 1303, the photoacoustic waves 1308 can be detected with a high sensitivity even when the light absorber 1307 is present very close to the surface of the inspection target 1306. Also, since the light irradiating portions 1304 are positioned in front of the ultrasonic receiving surface 1302, there is no need of boring a substrate which is used to form the ultrasonic probe 1300. Therefore, even the ultrasonic probe formed on a silicon substrate, such as a CMUT, can be easily manufactured.
An ultrasonic probe according to a first exemplary embodiment of the present invention will be described with reference to
In
More specifically, as shown in
The present invention is intended to minimize a physical distance between an inspection target, e.g., a living body, and a light source and a physical distance between the inspection target and the ultrasonic probe, thus reducing attenuations of both the light radiated from the light source and the ultrasonic waves generated from the inside of the living body, which are caused by the living body.
One practical method for realizing the structure of
The edge light type backlight refers to a backlight technique that is generally practiced in medium- or small-sized liquid crystal displays for cell phones and notebook PCs by employing a surface illuminant which comprises a light source, a light guide member, and a diffusion plate.
Referring to
The light source 240 (one or plural sources of light) is disposed at a side of the light guide member 250. The light propagates through the light guide member 250 while repeating total reflection. The light can be taken out to the exterior of the light guide member 250 by shaping a surface of the light guide member 250 or providing a scatterer in the surface of the light guide member 250 so as not to satisfy the condition of total reflection. As a result, the surface illuminant is obtained.
By controlling the surface shape or the scatterer, the surface illuminant can be designed to minimize variations in an in-plane luminance distribution. However, it is often difficult to sufficiently reduce in-plane variations in quantity of the radiated light by using only the light guide member 250.
For that reason, the diffusion plate or the like is employed to average the in-plane distribution of quantity of the radiated light, thus providing a surface illuminant that has a uniform light quantity.
A diffusion plate used in the liquid crystal display mainly serves to provide an image with uniform brightness in a display surface, and to reduce a significant change of luminance when the display surface is observed from various angles.
In contrast, the diffusion plate used in the ultrasonic probe according to the first exemplary embodiment mainly serves to irradiate the light in a maximum quantity while reducing a surface density of the light. A light density per unit area allowable for irradiation to a living body is determined according to industrial standards, and the irradiation of light at a density exceeding the allowable level is inhibited.
Accordingly, a larger quantity of light has to be irradiated in order to maximize the photoacoustic effect. To that end, variations in the in-plane distribution of light density should be held at a minimum. Therefore, the diffusion plate is used in the ultrasonic probe according to the first exemplary embodiment.
Further, from the viewpoint of efficiently irradiating the light to the inspection target, such as a tumor in a living body, it is desired that the light from the light source reaches the inspection target through the shortest distance. In other words, the ultrasonic probe is preferably designed so as to increase the quantity of light propagating in the direction normal to the surface light source.
The light source used in the present invention is selected to have a wavelength in an near-infrared range, as required, taking into account that the light source preferably has a wavelength at which an absorption by the inspection target appears significantly, and that the wavelength of the light source is preferably in a range where the light is highly transmissive through other areas in the living body than the target. In consideration of monochromaticity as well, a near-infrared laser is used.
Regarding the light guide member, a thin light guide member has recently been developed with an intent to realize a flexible structure of LCD, and it can be used as appropriate. The related art is disclosed, for example, in U.S. Pat. No. 6,773,126. Such a light guide member can be formed directly on the ultrasonic probe by an imprinting process, for example.
As with the need of increasing efficiency in the LCD backlight, the present invention also requires a larger quantity of light to be irradiated to the living body. The technique described, for example, in U.S. Pat. No. 6,967,698 can be employed to increase the quantity of light emitting from the light guide member.
Even when a light guide member is used, a light reflection layer can be disposed in the light guide member so that a larger quantity of light is irradiated to the living body.
The light reflection layer can be a metallic reflection plate that is ordinarily used. Because the living body is irradiated in the present invention with light of various wavelengths, including visible light and infrared light, the reflection plate is formed by using a metal that has a high reflectivity in the required wavelength band.
In that case, the reflectivity of the light reflection plate is set to be 90% or more from the viewpoint of increasing the efficiency.
If the reflectivity of the light reflection layer or the luminous efficiency of an illuminant is small, heat is generated in a light emission area, thus causing an error in measurement. To prevent such a measurement error, it is advantageous that the ultrasonic probe used in practice has a higher heat radiation effect.
Assuming that the wavelength of the ultrasonic wave detected by the ultrasonic transducing portion is λ, the thickness of the light guide member is set to (0.25×λ). The acoustic impedance of a material forming the light guide member is set at least to a value between the acoustic impedance of the ultrasonic transducing portion and the acoustic impedance of the inspection target. For example, the acoustic impedance of the light guide member can be set to a geometrical mean value of the acoustic impedance of the ultrasonic transducing portion and the acoustic impedance of the inspection target.
The ultrasonic transducing portions can be formed by using a piezoelectric substance, such as PZT, or a semiconductor. Also, the ultrasonic transducing portions can be constituted in the form separated into a plurality of transducers or as an array of ultrasonic vibrators. An ultrasonic receiving unit employed in the present invention is not particularly limited and can be a unit utilizing, e.g., a magnetostrictive phenomenon, an electrostrictive effect, a change of electrostatic attraction and capacity, or light.
The ultrasonic probe according to the first exemplary embodiment can be further used to transmit and receive ultrasonic waves and to provide an image by processing the reflected ultrasonic waves. The image provided by processing the reflected ultrasonic waves and the image obtained based on the photoacoustic effect can be displayed in an overlapping relation. Alternatively, the image provided by processing the reflected ultrasonic waves and the image obtained based on the photoacoustic effect can be displayed side by side.
In addition, the ultrasonic probe according to the first exemplary embodiment can include a photo detector. The photo detector can be used as a light-receiving portion for not only measurement and calibration of quantity and distribution of the incident (irradiated) light, but also for DOT (Diffuse Optical Tomography) which visualizes the interior of an observation target by causing light to transmit in the observation target.
An ultrasonic probe according to a second exemplary embodiment of the present invention will be described with reference to
In
On one side of the substrate 380 of the ultrasonic probe, the ultrasonic transducing portions 310 are arranged in a two-dimensional array. For example, the substrate 380 has a 3-cm square shape, and each of the ultrasonic transducing portions 310 has a 0.5-mm square shape. Those ultrasonic transducing portions 310 are arranged at a pitch of 2 mm in each of the lengthwise and widthwise directions. When the ultrasonic transducing portion 310 is a CMUT, the frequency changes depending on the size of the ultrasonic transducing portion. Therefore, a plurality of small ultrasonic transducing portions having respective desired bands can be arranged side by side and can be driven by interconnecting their electrodes as required.
The light guide member 370 is disposed on a surface of the substrate 380 on the side including the ultrasonic transducing portions 310. The laser beam 320 is irradiated from one end of the light guide member 370 to propagate through the light guide member 370.
After propagating through the light guide member 370, the laser beam 320 is scattered by the light scatterer 330 disposed at the end surface 350 and is introduced into the inspection target 340. The light scatterer 330 can be arranged on three of four surfaces of the light guide member 370, which are vertically disposed relative to a horizontal incident axis of the laser beam 320, except for the remaining one surface upon which the laser beam 320 is incident. Such an arrangement enables the laser beam to be introduced into the inspection target 340 with higher efficiency. The light guide member 370 is formed of a hollow housing made of, e.g., vinyl or glass, and is filled with a liquid, e.g., water.
In particular, portions of the light guide member 370, which contact the inspection target 340 and the ultrasonic transducing portions 310, can be formed, for example, of a Mylar film that is highly transmissive to ultrasonic waves. The light guide member using the Mylar film can introduce the ultrasonic waves generated from the inspection target 340 into the ultrasonic transducing portions 310 with higher efficiency than the light guide member made of a solid material. Further, the light scatterer 330 can be formed in any shape so long as it has asperities (unevenness) in larger size than the wavelength used.
An ultrasonic probe according to a third exemplary embodiment of the present invention will be described below with reference to
On one side of a substrate 400 of the ultrasonic probe, ultrasonic transducing portions 401, such as piezoelectric transducers or CMUTs, are arranged in a two-dimensional array.
A light guide member 402 is disposed on a surface of the substrate 400 on the side including the ultrasonic transducing portions 401. Terminal ends 403 of optical fibers are fixed to opposite ends of the light guide member 402. The light guide member 402 contacts the inspection target 404 with an acoustic coupling member 405 interposed between them.
A light 406 having propagated through the optical fibers 403 is introduced into the light guide member 402 from the opposite ends thereof. The light 406 introduced into the light guide member 402 propagates through the interior of the light guide member 402 as indicated by arrows 407, and is then radiated toward the inspection target 404 from light irradiating portions 408 as indicated by arrows 409. If there is a light absorber 410 inside the inspection target 404, the temperature of the light absorber 410 increases selectively to such an extent that the light absorber 410 emits photoacoustic waves 411. The photoacoustic waves 411 are received by the ultrasonic transducing portions 401 through the acoustic coupling member 405.
To promote the introduction of the light 406 into the light guide member 402 from the optical fibers 403, a textured structure is provided in a lateral surface 412 of each optical fiber 403, or fine particles having a light diffusion function are dispersed in the optical fiber.
In a desired state, the light 406 is uniformly introduced into the light guide member 402 over the entire opposite ends thereof. The reason is that, if the light is non-uniformly introduced, variations are caused in the irradiated light intensity in the lengthwise direction of the substrate. To eliminate such variations, the size of the textured structure provided in the optical-fiber lateral surface 412 and/or the density of fine particles dispersed in the optical fibers are adjusted so as to gradually increase the degree of dispersion (i.e., a light diffusion function) from the entry side of the light 406 toward the innermost side. It is also desired that the light radiation 409 from the light guide member 402 is uniformly performed over the entire substrate.
In particular, when observing the light absorber 410 which is located at a shallow position from the surface of the inspection target 404, it is more efficient to selectively introduce the light 406 through the light irradiating portions 408 which are positioned just above the ultrasonic transducing portions 410. To that end, the refractive index of the light guide member 402 is set to be larger than that of the acoustic coupling member 405 so that the propagating light 407 is enclosed within the light guide member 402 by total reflection.
Further, light diffusion in the light irradiating portions 408 can be promoted by selectively providing a textured structure in the surface of the light guide member 402, or by dispersing fine particles with a light diffusion function inside the light guide member 402. Additionally, it is desired that the light diffusion function is gradually enhanced from the entry side of the propagating light 407 toward the innermost side.
On the other hand, the light guide member 402 is required to efficiently propagate the photoacoustic waves 411 from the light absorber 410 in the direction of thickness of the light guide member 402. To that end, the light guide member 402 is made of a material having an acoustic impedance between those of the inspection target 404 and the ultrasonic transducing portions 401. Further, the material of the light guide member 402 is selected to have a large Poisson's ratio (near 0.5) in order not to impede vibrations in the ultrasonic transducing portions. As a material satisfying the above-described requirements, there is silicone rubber conventionally used for an acoustic lens in a one-dimensional ultrasonic probe.
Because the refractive index of silicone rubber with respect to visible light or near-infrared light is about 1.4-1.5, water (refractive index of 1.33) or ethanol (refractive index of 1.37), for example, can be used as the acoustic coupling member 405 from the viewpoint of enclosing light within the light guide member 402.
When the textured structure is formed in the surface of the silicone rubber, the size of the textured structure is required to be not smaller than the wavelength (0.5-1.5 μm) of the used light from the viewpoint of light diffusion. However, if the size of the textured structure is near the wavelength (1.5-0.15 mm at frequency of 1-10 MHz) of ultrasonic waves, the textured structure scatters the ultrasonic waves. Therefore, the size of the textured structure is set to a value between the wavelength of the used light and the wavelength of the ultrasonic waves.
The dispersed fine particles can be made of SiO2 having a particle size of about 2 μm, for example.
In addition, providing a light reflection surface 413 between the light guide member 402 and the substrate 400 and between the light guide member 402 and the ultrasonic transducing portions 401 is effective in not only increasing the light utilization efficiency, but also preventing undesired acoustic waves (noise) from being generated in the substrate surface, etc. Further, when the light guide member 402 has an end through which the light is not introduced, the provision of a light reflection layer 414 enables the light to be utilized with higher efficiency.
An ultrasonic probe according to a fourth exemplary embodiment of the present invention will be described with reference to
In the fourth exemplary embodiment, the light irradiating portions 408 are constituted by forming the surface of the light guide member 402 to have curved surface portions. In the curved surface portions, the condition of total reflection based on the difference in refractive index between the light guide member 402 and the acoustic coupling member 405 is not satisfied optically, and the light is radiated toward the inspection target 404 through the curved surface portions.
In an acoustic point of view, because the velocity of sound in silicone rubber is 900-1000 m/sec and the velocity of sound in water is 1480 m/sec, the curved surface portions which are upwardly convex as shown in
An ultrasonic probe according to a fifth exemplary embodiment of the present invention will be described with reference to
In the fifth exemplary embodiment, the refractive index of the light guide member 402 is set to be smaller than that of the acoustic coupling member 405. Therefore, the condition for enclosing the light is not satisfied and the light is radiated toward the inspection target 404.
However, the light can be efficiently utilized by forming, on the surface of the light guide member 402, a light-shield mask layer 600 which has openings in positions corresponding to the light irradiating portions 408. In other words, areas (openings) not covered with the light-shield mask layer 600 serve as the light irradiating portions.
As with the third exemplary embodiment described above with reference to
In the fifth exemplary embodiment, the acoustic coupling member 405 can be generally made of a material having a high viscosity. For example, even when glycerin (refractive index of 1.47) is used as the material of the acoustic coupling member 405, the setting not to satisfy the light enclosing condition can be realized by selecting an appropriate type of silicone rubber of which refractive index is lower than that of glycerin. The highly-viscous acoustic coupling member 405 is convenient in use because the acoustic coupling member 405 becomes less apt to leak externally when it is inserted between the inspection target 404 and the light guide member 402.
A sixth exemplary embodiment of the present invention will be described with reference to
The sixth exemplary embodiment is described in connection with the case where the present invention is applied to mamma diagnosis (i.e., mammography).
In
Further, numeral 1007 denotes an ultrasonic probe that is one of the ultrasonic probes described in the foregoing exemplary embodiments. With such an arrangement, as indicated by 1002 and 1008, since the light can be irradiated to the mamma 1000 from the both sides, an image of a tissue highly absorbing the light, e.g., a new blood vessel 1006 generated with a cancer, can be obtained at a high contrast. Further, since one of the ultrasonic probes described in the foregoing exemplary embodiments is used as the ultrasonic probe 1007, a portion which has been located in shades in the past can also be effectively illuminated by the light 1008 from the ultrasonic probe 1007.
A seventh exemplary embodiment of the present invention will be described with reference to
The seventh exemplary embodiment is also described in connection with the case where the present invention is applied to mamma diagnosis (i.e., mammography). The seventh exemplary embodiment uses two ultrasonic probes 1007, i.e., a first ultrasonic probe and a second ultrasonic probe, each being the same as that in the sixth embodiment.
The two ultrasonic probes 1007 can be constructed such that they have independent light sources and can generate light pulses at the same time under control by a common optical control unit. The arrangement may be modified such that a light pulse from a common light source is divided into two light pulses which are propagated to the ultrasonic probes through respective waveguides and are radiated from the light irradiating portions in each of the two ultrasonic probes.
Image data including lesser defects (artifacts) can be obtained by synthetically processing signals which are received by a plurality of ultrasonic probes at different incident angles, as in this seventh exemplary embodiment.
The two ultrasonic probes can be arranged not only in an exactly opposed relation, but also in a state where they are opposed in a relatively shifted relation as shown in
An inspection apparatus can be constructed by using one of the ultrasonic probes described in the foregoing exemplary embodiments. The inspection apparatus is practiced as an ultrasonic image forming apparatus utilizing the aforementioned PAT technique. Therefore, the inspection apparatus according to the eighth exemplary embodiment includes a display unit (monitor) for displaying, as image data, internal information of the inspection target by using received signals from the ultrasonic probe.
The internal information can be a tomographic image or a three-dimensional shape, for example, and it is provided by representing parameters regarding features of the inspection target in the form of an image.
A practical example of the inspection apparatus is described below.
The inspection apparatus further includes an optical control unit 920 for controlling the wavelength, the driving timing, and the output of a light source, and an ultrasonic transmitting unit 930 for scanning ultrasonic waves to observe the interior of the inspection target. In the inspection apparatus employing the PAT technique, transmission of ultrasonic waves is not necessarily required. Signals output from a group of ultrasonic vibrators, which serve as the ultrasonic transducing portions, are transmitted in a wired or wireless way and are received by a receiving unit 910.
Numeral 960 denotes a signal processing unit including a photoacoustic signal processing unit 961 and an ultrasonic signal processing unit 962.
The photoacoustic signal processing unit 961 executes arithmetic and other processing of photoacoustic signals, which are obtained from the group of ultrasonic vibrators, to calculate the direction and the intensity of the photoacoustic signals generated in the inspection target.
When ultrasonic waves are transmitted, the ultrasonic signal processing unit 962 calculates the intensity of reflected ultrasonic waves depending on the transmitting direction of the ultrasonic waves. When no ultrasonic waves are transmitted, the ultrasonic signal processing unit 962 can be dispensed with.
An image data processing unit 950 executes, for example, reconstruction of an image, coordinate transformation, edge enhancement, contrast adjustment, and overlapping of an image obtained from the photoacoustic signals with an image obtained from the ultrasonic signals. Data processed by the image data processing unit 950 is displayed on the monitor 970.
While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. The scope of the following claims is to be accorded the broadest interpretation so as to encompass all modifications and equivalent structures and functions.
This application claims the benefit of Japanese Patent Application No. 2007-172746 filed Jun. 29, 2007, which is hereby incorporated by reference herein in its entirety.
| Number | Date | Country | Kind |
|---|---|---|---|
| 2007-172746 | Jun 2007 | JP | national |
| 2008-146997 | Jun 2008 | JP | national |
This application is a divisional of application Ser. No. 13/804,889, filed Mar. 14, 2013, which is a divisional of application Ser. No. 12/145,224, filed Jun. 24, 2008, claims benefit of both applications under 35 U.S.C. § 120, and claims benefit under 35 U.S.C. § 119 of Japanese Patent Applications Nos. 2007-172746 and 2008-146997, filed on Jun. 29, 2007, and Jun. 4, 2008, respectively. The entire contents of each of the four mentioned prior applications are incorporated herein by reference.
| Number | Date | Country | |
|---|---|---|---|
| Parent | 13804889 | Mar 2013 | US |
| Child | 15398143 | US | |
| Parent | 12145224 | Jun 2008 | US |
| Child | 13804889 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 15398143 | Jan 2017 | US |
| Child | 16209324 | US |
