Claims
- 1. A contrast agent comprising stabilized microbubbles, said stabilized microbubbles comprising a physiologically acceptable gas selected from the group consisting of freons, halogenated hydrocarbons, and fluorinated gases, said stabilized microbubbles being stabilized, at least in part, by a surfactant.
- 2. A contrast agent comprising stabilized microbubbles, said stabilized microbubbles comprising a physiologically acceptable gas that is a freon, said stabilized microbubbles being stabilized, at least in part, by a surfactant.
- 3. The contrast agent of claim 1 wherein said stabilized microbubbles are suspended in a carrier.
- 4. The contrast agent of claim 1 wherein said stabilized microbubbles are suspended in an aqueous liquid carrier.
- 5. The contrast agent of claim 1 wherein said stabilized microbubbles are between 0.5 and 10 microns in size.
- 6. The contrast agent of claim 1 wherein the stabilized microbubbles are sufficiently stable and resistant to pressure changes that they survive in the bloodstream long enough that they may be peripherally intravenously injected, travel through the right heart, through the lungs, and into the left heart without substantially dissolving.
- 7. The contrast agent of claim 1 wherein the physiologically acceptable freon is selected from the group consisting of CF4, CBrF3, C4F8, CClF3, C2F6, C3F8, C4F6, C2ClF3, CBrClF2, C2Cl2F4, C5F10, C5F12, and C4F10.
- 8. The contrast agent of claim 1 wherein the physiologically acceptable fluorinated gas is selected from the group consisting of SF6, SeF6, CF4, CBrF3, C4F8, CClF3, C2F6, C3F8, C4F6, C2ClF5, CBrClF2, C2Cl2F4, C5F10, C5F12, and C4F10.
- 9. The contrast agent of claim 2 wherein the physiologically acceptable freon is selected from the group consisting of CF4, CBrF3, C4F8, CClF3, C2F6, C3F8, C4F6, C2ClF5, CBrClF2C2, Cl2F4, C5F10, C5F12, and C4F10.
- 10. The contrast agent of claim 2 wherein the physiologically acceptable freon is selected from the group consisting of CF4, C4F8, C2F6, C3F8, C4F6, C5F10, C 5F12, and C4F10.
- 11. The contrast agent of claim 1 wherein the physiologically acceptable freon is selected from the group consisting of CF4, C2F6, C3F8, C4F6, C4F8, C5F10, C5F12, and C4F10.
- 12. The contrast agent of claim 1 wherein the physiologically acceptable fluorinated gas comprises SF6.
- 13. The contrast agent of claim 1 wherein the physiologically acceptble fluorinated gas comprises SeF6.
- 14. The contrast agent of claim 1 wherein the physiologically acceptable freon comprises CF4.
- 15. The contrast agent of claim 1 wherein the physiologically acceptable freon comprises CBrF3.
- 16. The contrast agent of claim 1 wherein the physiologically acceptable freon comprises C4F8.
- 17. The contrast agent of claim 1 wherein the physiologically acceptable freon comprises CClF3.
- 18. The contrast agent of claim 1 wherein the physiologically acceptable freon comprises C2F6.
- 19. The contrast agent of claim 1 wherein the physiologically acceptable freon comprises C2ClF8.
- 20. The contrast agent of claim 1 wherein the physiologically acceptable freon comprises CBrCIF2.
- 21. The contrast agent of claim 1 wherein the physiologically acceptable freon comprises C2Cl2F4.
- 22. The contrast agent of claim 1 wherein the physiologically acceptable freon comprises C4F10.
- 23. The contrast agent of claim 1 wherein the physiologicaly acceptable freon comprises C3F8.
- 24. The contrast agent of claim 1 wherein the physiologicaly acceptable freon comprises C4F6.
- 25. The contrast agent of claim 1 wherein the physiologicaly acceptable freon comprises C5F10.
- 26. The contrast agent of claim 1 wherein the physiologicaly acceptable freon comprises C5F12.
Priority Claims (5)
Number |
Date |
Country |
Kind |
90810262.7 |
Apr 1990 |
EP |
|
90810367.4 |
May 1990 |
EP |
|
PCT/EP91/00620 |
Apr 1991 |
WO |
|
92810046.0 |
Jan 1992 |
EP |
|
93810885.9 |
Dec 1993 |
EP |
|
Parent Case Info
[0001] This application is a continuation-in-part of Ser. No. 08/910,152, filed Aug. 13, 1997, which is still pending, which is a divisional of Ser. No. 08/288,550, filed Aug. 10, 1994, now U.S. Pat. No. 5,711,933, which is a divisional of Ser. No. 08/033,435, filed Mar. 18, 1993, which is a divisional of Ser. No. 07/695,343, filed May 3, 1991, which originated from EP 90810367.4, filed May 18, 1990. This application is also a continuation-in-part of Ser. No. 08/853,936, filed May 9, 1997, which is still pending, which is a divisional of Ser. No. 08/456,385, filed Jun. 1, 1995, now U.S. Pat. No. 5,658,551, which is a divisional of Ser. No. 08/315,347, filed Sep. 30, 1994, now U.S. Pat. No. 5,531,980, which is a divisional of Ser. No. 08/128,540, filed Sep. 29, 1993, now U.S. Pat. No. 5,380,519, which is a divisional of Ser. No. 07/775,989, filed Nov. 20, 1991, now U.S. Pat. No. 5,271,928, which originated from PCT/EP91/00620, filed Apr. 2, 1991, and EP 90810262.7, filed Apr. 2, 1990. This application is also a continuation-in-part of Ser. No. 081740,653, filed Oct. 31. 1996, which is still pending, which is a divisional of Ser. No. 08/350,588, filed Jan. 30, 1995, now U.S. Pat. No. 5,578,292, which is a divisional of Ser. No. 07/991,237, filed Dec. 16, 1992, now U.S. Pat. No. 5,413,774, which originated from EP 92810046.0, filed Jan. 24, 199. This application is also a continuation-in-part of Ser. No. 08/637,346, filed Apr. 25, 1996, now abandoned, which is a divisional of Ser. No. 08/352,108, filed Nov. 30, 1994, now U.S. Pat. No. 5,556,610, which originated from EP 93810885.9, filed Dec. 15, 1993 and which is a continuation-in-part of Ser. No. 07/991,237. All of the aforementioned applications are hereby incorporated by reference herein in their entirety.
Divisions (10)
|
Number |
Date |
Country |
Parent |
08288550 |
Aug 1994 |
US |
Child |
08910152 |
Aug 1997 |
US |
Parent |
08033435 |
Mar 1993 |
US |
Child |
08288550 |
Aug 1994 |
US |
Parent |
07695343 |
May 1991 |
US |
Child |
08033435 |
Mar 1993 |
US |
Parent |
08456385 |
Jun 1995 |
US |
Child |
08853936 |
May 1997 |
US |
Parent |
08315347 |
Sep 1994 |
US |
Child |
08456385 |
Jun 1995 |
US |
Parent |
08128540 |
Sep 1993 |
US |
Child |
08315347 |
Sep 1994 |
US |
Parent |
07775989 |
Nov 1991 |
US |
Child |
08128540 |
Sep 1993 |
US |
Parent |
08380588 |
Jan 1995 |
US |
Child |
08740653 |
Oct 1996 |
US |
Parent |
07991237 |
Dec 1992 |
US |
Child |
08380588 |
Jan 1995 |
US |
Parent |
08352108 |
Nov 1994 |
US |
Child |
08637346 |
Apr 1996 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
09266889 |
Mar 1999 |
US |
Child |
10809677 |
Mar 2004 |
US |
Continuation in Parts (5)
|
Number |
Date |
Country |
Parent |
08910152 |
Aug 1997 |
US |
Child |
09266889 |
Mar 1999 |
US |
Parent |
08853936 |
May 1997 |
US |
Child |
10809677 |
Mar 2004 |
US |
Parent |
08740653 |
Oct 1996 |
US |
Child |
10809677 |
Mar 2004 |
US |
Parent |
08637346 |
Apr 1996 |
US |
Child |
10809677 |
Mar 2004 |
US |
Parent |
07991237 |
Dec 1992 |
US |
Child |
08352108 |
Nov 1994 |
US |