UniProt - Enhancing functional genomics data access for the Alzheimer's Disease (AD) and dementia-related protein research communities

Information

  • Research Project
  • 10121011
  • ApplicationId
    10121011
  • Core Project Number
    U24HG007822
  • Full Project Number
    3U24HG007822-07S1
  • Serial Number
    007822
  • FOA Number
    PA-18-591
  • Sub Project Id
  • Project Start Date
    9/18/2014 - 10 years ago
  • Project End Date
    5/31/2021 - 3 years ago
  • Program Officer Name
    PILLAI, AJAY
  • Budget Start Date
    7/1/2020 - 4 years ago
  • Budget End Date
    5/31/2021 - 3 years ago
  • Fiscal Year
    2020
  • Support Year
    07
  • Suffix
    S1
  • Award Notice Date
    6/30/2020 - 4 years ago

UniProt - Enhancing functional genomics data access for the Alzheimer's Disease (AD) and dementia-related protein research communities

PROJECT SUMMARY UNIPROT - ENHANCING FUNCTIONAL GENOMICS DATA ACCESS FOR THE ALZHEIMER?S DISEASE (AD) AND DEMENTIA-RELATED PROTEIN RESEARCH COMMUNITIES - SUPPLEMENT REQUEST 2020 The mission of the Universal Protein Resource (UniProt) is to support biomedical research by providing a freely available, stable, comprehensive, richly and accurately annotated protein sequence KnowledgeBase (UniProtKB). Currently, 5.7 million US citizens are living with the effects of Alzheimer?s Disease (AD), which is estimated to rise to 14 million by 2025. A National Plan has been implemented by the US aimed at preventing and effectively treating AD and related dementias by 2025. To support precision medicine based on genomic data, UniProt is tasked with providing a centralized resource that both links the genome to the functional proteins it encodes. It also efficiently identifies, captures and disseminates published information on protein function, facilitating computational analysis. The goal of this supplement is to further enhance the usability and content of the AD pages in the prototypic Disease Portal, in response to feedback obtained at a series of NIA-funded AD workshops. We will enable users access to protein pages for genes associated with the disease that have been identified by several groups active in the field, and make these easily discoverable by use of additional disease ontologies. We will provide graphical views of protein expression data and links to data on orthologous genes/proteins in model organism species. We will use text mining to supplement the results of expert literature curation and determine ways in which the research community can directly contribute to UniProt records.

IC Name
NATIONAL HUMAN GENOME RESEARCH INSTITUTE
  • Activity
    U24
  • Administering IC
    HG
  • Application Type
    3
  • Direct Cost Amount
    309241
  • Indirect Cost Amount
    9410
  • Total Cost
    318651
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    172
  • Ed Inst. Type
  • Funding ICs
    NIA:318651\
  • Funding Mechanism
    OTHER RESEARCH-RELATED
  • Study Section
    ZHG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    EUROPEAN MOLECULAR BIOLOGY LABORATORY
  • Organization Department
  • Organization DUNS
    321691735
  • Organization City
    HEIDELBERG
  • Organization State
  • Organization Country
    GERMANY
  • Organization Zip Code
    69117
  • Organization District
    GERMANY