Claims
- 1. A compound having the formula ##STR6## where R.sup.1 and R.sup.2 are both hydrogen or R.sup.1 and R.sup.2 form a bond;
- m=1 and n=3 and p=6,
- or m=3, 5 or 7 and n=1 and p=6,
- or m=4 and n=2 and p=6 or 8,
- and the E (trans) and Z (cis) isomers when R.sup.1 =R.sup.2 =H;
- or a pharmaceutically acceptable basic addition salt thereof.
- 2. A compound according to claim 1 which is 2-�((Z)-1-oxo-9-octadecenyl)amino!-4-thiazoleacetic acid.
- 3. A compound according to claim 1 which is 2-�((Z)-1-oxo-9-octadecenyl)amino!-4-thizaoleacetic acid, tromethamine (2-amino-2-hydroxymethyl)-1,3-propanediol) salt.
- 4. A compound according to claim 1 which is 2-�((E)-1-oxo-9-octadecenyl)amino!-4-thiazoleacetic acid.
- 5. A compound according to claim 1 which is 2-�(1-oxo-9-octadecenyl)amino!-4-thiazoleacetic acid.
- 6. A compound according to claim 1 which is 2-�(1-oxo-9-octadecynyl)amino!-4-thiazoleacetic acid, tromethamine salt.
- 7. A compound according to claim 1 which is 2-�((EE)-1-oxo-9,12-tetradecadienyl)amino!-4-thiazoleacetic acid.
- 8. A compound according to claim 1 which is 2-�((Z,Z,Z)-1-oxo-9,12,15-octadecatrienyl)amino!-4-thiazole-acetic acid.
- 9. A compound according to claim 1 which is 2-�((Z)-1-oxo-9-tetradecenyl)amino!-4-thiazoleacetic acid.
- 10. A compound according to claim 1 which is 2�((Z)-1-oxo-9-tetradecenyl)amino!-4-thiazoleacetic acid, tromethamine salt.
- 11. A compound according to claim 1 which is 2�((Z,Z)-1-oxo-11,14-eicosadienyl)amino!-4-thiazoleacetic acid.
- 12. A method of treating inflammatory diseases mediated by arachidonic acid metabolites which comprises administering to a mammal needing such treatment a phospholipase A.sub.2 -inhibiting amount of a compound having the formula ##STR7## where R.sup.1 and R.sup.2 are both hydrogen or R.sup.1 and R.sup.2 form a bond;
- m=1 and n=3 and p=6,
- or m=3, 5 or 7 and n=1 and p=6,
- or m=4 and n=2 and p=6 or 8,
- and the E (trans) and Z (cis) isomers when R.sup.1 =R.sup.2 =H;
- or a pharmaceutically acceptable basic addition salt thereof.
- 13. A method of treatment according to claim 12 wherein the inflammatory disease treated is rheumatoid arthritis.
- 14. A method of treatment according to claim 12 wherein the inflammatory disease treated is ulcerative colitis.
- 15. A method of treatment according to claim 12 wherein the inflammatory disease treated is psoriasis.
- 16. A method of treatment according to claim 12 wherein the inflammatory disease treated is allergic bronchial asthma or allergic rhinitis.
- 17. A pharmaceutical composition which comprises a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of the formula ##STR8## where R.sup.1 and R.sup.2 are both hydrogen or R.sup.1 and R.sup.2 form a bond;
- m=1 and n=3 and p=6,
- or m=3, 5 or 7 and n=1 and p=6,
- or m=4 and n=2 and p=6 or 8,
- and the E (trans) and Z (cis) isomers when R.sup.1 =R.sup.2 =H;
- or a pharmaceutically acceptable basic addition salt thereof.
Parent Case Info
This application claims priority to the U.S. provisional application Ser. No. 60/009,332 filed Dec. 28, 1995.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4954489 |
Ponsford |
Sep 1990 |
|