Urea derivatives and their use as herbicides

Abstract

Compounds, useful as herbicides, of the formula ##SPC1##Wherein R.sub.1 is haloalkyl, halocycloalkyl, haloalkenyl, or halocycloalkenyl; n.sub.1 is 1 or 2; R.sub.4 is halogen, trifluoromethyl, alkyl, or alkoxy; n.sub.2 is 0, 1, 2, or 3; R.sub.2 is hydrogen or alkyl; and R.sub.3 is alkyl or alkoxy.Methods for making these compounds.

Description

The present invention relates to novel derivatives of the general formula ##SPC2##

In which R.sub.1 stands for a haloalkyl, halocycloalkyl, haloalkenyl or halocycloalkenyl radical each having 2 to 5 carbon atoms, the halogen being fluoride, chlorine and/or bromine, n.sub.1 is 1 or 2, R.sub.4 stands for a halogen atom, the trifluoromethyl-radical or for an alkyl- or alkoxy-radical with 1 to 3 carbon atoms, n.sub.2 is 0, 1, 2 or 3, R.sub.2 stands for a hydrogen atom or an alkyl radical with 1 to 4 carbon atoms and R.sub.3 stands for an alkyl- or alkoxy-radical each having 1 to 4 carbon atoms.

The specified compounds are obtained by reacting 1. halogenoalkoxy-arylisocyanates or halogenoalkoxy-arylcarbamic acid chlorides with

A. alkyl- or dialkyl-amines or O-alkyl- or O,N-dialkyl-hydroxylamines or B. O-alkylhydroxyl-amines with subsequent alkylation or C. N-alkylhydroxyl-amines with subsequent alkylation or D. hydroxyl-amine with subsequent dialkylation; or reacting

2. HLAOGENOALKOXY-ARYLAMINES WITH ALKYLISOCYANATES OR DIALKYLCARBAMIC ACID CHLORIDES.

The compounds can be prepared, for example, in one of the following ways: ##SPC3##

The reactions of the halogenoalkoxy-arylisocyanates or carbamic acid chlorides with the amines or alkylated hydroxylamines are preferably carried out at a temperature below 80.degree.C in the presence or absence of a diluent. Suitable diluents are, for example, benzene, toluene, dioxane or dimethyl formamide.

The corresponding reactions with hydroxylamine are advantageously performed at a temperature below 40.degree.C, in a two-phase mixture of water and an organic solvent immiscible with water.

The alkylations are suitably carried out in aqueous alkaline suspension or in mixtures of aqueous alkali and an organic solvent. The alkali metal hydroxide solution and the alkylating agent are advantageously added simultaneously. Alternatively, the urea may be placed first in the reaction vessel together with the alkylating agent in an organic solvent and the alkali metal hydroxide solution may then be added or, in the case of compounds that are less sensitive towards alkali, the order of addition may be reversed. The reaction temperature naturally depends on the reactivity of the alkylating agents used and is in the range from 10.degree. to 90.degree.C.

The alkylations in processes 1b), 1c), and 1d) are carried out with dialkyl-sulfates, alkyl halides or alkyltoluene-sulfonates. In 2) anilines carrying corresponding substituents are used.

Suitable starting compounds for processes 1a), 1b), 1c), and 1d) are, for example, 3- or 4-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenylisocyanate, 3-methyl-4-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenylisocyanate, 3- or 4-(1',1',2',2',-tetra-fluoro-ethoxy)-phenylisocyanate, 3-methyl-4-(1',1',2',2'-tetrafluoro-ethoxy)-phenylisocyanate, 3- or 4-(1',1',2',3',3',3'-hexafluoro-propoxy)-phenylisocyanate, 3-methyl-4-(1',1',2',3',3',3'-hexafluoro-propoxy)-phenylisocyanate, 3-(1',1',2'-trifluoro-ethoxy)-phenylisocyanate, 3- or 4-(1',1',2'-trifluoro-2'-bromo-ethoxy)-phenylisocyanate, 3-methyl-4-(1',1',2'-trifluoro-2'-bromo-ethoxy)-phenylisocyanate, 3- or 4-(1',1'-difluoro-2',2'-dichloro-ethoxy)-phenylisocyanate, 4-(3',3'-dichloroallyloxy)-phenylisocyanate, 4-(2',3',3'-trichloroallyloxy)-phenylisocyanate, 4-(1',2'-dichlorovinyloxy)-phenylisocyanate, 3-chloro-4-(2'-chloroethoxy)-phenylisocyanate, 3-methyl-4-(2'-chloroethoxy)-phenylisocyanate and 3-trifluoromethyl-4 -(2'-chloro-ethoxy)-phenylisocyanate and other analogous phenylisocyanates having in the R.sub.4 -position for example chloro- or bromo-, or the methyl-, methoxy-, ethyl- or propyl -radical.

Instead of the isocyanates phenylcarbamic acid chlorides carrying the corresponding substituents may also be used.

The novel isocyanates are obtained by phosgenation of the corresponding amines or the hydrochlorides which can be prepared by the following methods A, B, C and D.

Method A consists in the reaction of alkali metal nitrophenolates with halogenated alkenes (trichloroethylene, tribromoethylene, trichloropropene, tetrachloropropene), halogenated cycloalkenes (hexafluoro-dichloro-cyclopentene, tetrafluoro-dichloro-cyclobutene) and halogenated alkanes (1,1-difluoro-1,2,2-tri-ethane chloride etc.) analogous to (1) British patent specification 617 820; C.A. 43 (1949) 7045 et seq., (2) Ber. 96 (1963) 52, (3) Ind. Chem. 39 (1947) 412; and the subsequent catalytic reduction of the nitro-compound thus obtained.

The following examples serve to illustrate the reaction conditions.

Example: Preparation of 3-(1',2'-dichlorovinyloxy)-aniline

161 grams (1 mole) of 3-nitrophenol sodium were dissolved in 400 milliliters of dimethyl formamide and 145 grams (1.1 mole) of trichloroethylene were dropped in at 60.degree.C. Subsequently the mixture was stirred for 6 hours at 80.degree.C. The main amount of dimethyl formamide was distilled off in vacuo. The oily residue was poured into ice water, was separated, dried over Na.sub.2 SO.sub.4 and distilled.

b.p..sub.0.01 mm: 115.degree. - 117.degree.C;

Yield: 115 grams of 3-(1',2'-dichlorovinyloxy)-nitrobenzene 1 mole of the nitro-product was dissolved in 1liter of ethanol and was reduced by means of hydrogen in an autoclave at 60.degree.C, after 5 grams of a Raney-nickel catalyst (R/50) had been added. The catalyst was then filtered off with suction, the ethanol was distilled off, and the residue was distilled in vacuo.

b.p..sub.o.5 mm: 116.degree. - 118.degree.C

Yield: 121 grams of 3-(1',2'-dichlorovinyloxy)-aniline.

Method B consists in the reaction of nitro- or acetamino-phenols with halogenated alkanes (1,1-difluoro-1,2,2-trichloroethane, 1,1,2-trifluoro-1,2-dibromoethane) and halogenated alkenes (trichloroethylene etc.) in the presence of K.sub.2 CO.sub.3 analogous to (4) J. Am. Chem. Soc. 70 (1948) 593; and in the conversion of the nitro-compound into aniline, as described by Method A, or the cleavage of the acetamino compound into the aniline hydrochloride.

The following example serves to illustrate the process:

Example: Preparation of 3-acetamino-(1',1'-difluoro-2',2'-dichloro)-phenetol.

151 grams (1 mole) of 3-acetamino-phenol were dissolved in 400 milliliters of dimethyl formamide, and 138 grams (1mole) of K.sub.2 CO.sub.3 were added while stirring, 186 grams (1.1 mole) of 1,1-difluoro-1,2,2-trichloro-ethane were dropped into the mixture at 60.degree.C; the mixture was maintained at 80.degree.C for 6 hours and was then poured into about 4 liters of ice water. The precipitated crystalline product was filtered off with suction and dried.

Melting point: 72.degree. - 74.degree.C

Yield: 281 grams of 3-acetamino-(1',1'-difluoro-2',2'-dichloro)-phenetol 1 mole of acetamino compound was dissolved in 2liters of hydrochloric acid of 18 % strength, while heating, and was maintained at 100.degree.C for 2 hours. After cooling, the precipitated crystalline product was filtered off with suction and dried.

Melting point: 227.degree.C;

Yield: 230 grams of 3-(1',1'-difluoro-2',2'-dichloroethoxy)aniline hydrochloride.

Method C consists in the reaction of nitro-phenols or amino-phenols, in particular 3-amino-phenol, with halogenated alkenes (tetrafluoro-ethylene, trifluoro-ethylene, trifluoro-chloroethylene, hexafluoro-propene, difluoro-dichloroethylene etc.) analogous to (5) J. Am. Chem. Soc. 73 (1951) 5831; (6) Bull. Soc. chim. France [5] 1957, 581; and subsequent catalytic reduction, as described by Method A.

EXAMPLE: Preparation of 3-(1',1',2'-trifluoro-2'-chloroethoxy)-aniline

139 grams (1 mole) of 3-nitro-phenol and 28 grams (0.5 mole) of potassium hydroxide were dissolved in 400 milliliters of dimethyl formamide, and 140 grams (1.2 mole) of trifluorochloroethylene were introduced in a gas pipe at 40.degree.C; the mixture was then maintained at 60.degree.C for 2hours. The main amount of dimethyl formamide was distilled off in vacuo. The residue was poured into ice water, separated, dried over Na.sub.2 SO.sub.4 and distilled in vacuo.

Kp.sub.0.3 mm: 89.degree. - 90.degree.C;

Yield: 176 grams of 3-nitro-(1',1',2'-trifluoro-2'-trifluoro-2'-chloro)-phenetol.

1 mole of the nitro-compound was reduced as described by Method A.

b.p..sub.0.1 mm: 86.degree.C

Yield: 171 grams of 3-(1',1',2'-trifluoro-2'-chloroethoxy)-aniline.

When in the example mentioned above 1 mole of 3-amino-phenol was used instead of 3-nitro-phenol, the 3-(1',1',2'-trifluoro-2'-chloroethoxy)-aniline was obtained directly.

Method D consists in the reaction of nitro-phenolates with .beta.-chloroethyl-p-toluene sulfonate analogous to (7) J. Chem. Soc. 121 (1922) 644, and subsequent catalytic reduction of the nitro-products obtained into the anilines, as described by Method A.

Example: Preparation of 4-(2'-chloroethoxy)-aniline

42 grams (1.05 mole) of sodium hydroxide were dissolved in 75 milliliters of water, and 139 grams (1 mole) of 4-nitrophenol and 235 grams (1 mole) of .beta.-chloroethyl-p-toluene sulfonate were added, while stirring. Subsequently the reaction mixture was heated at 100.degree.C for 4 hours. After cooling, the mixture was made alkaline by means of a solution of sodium hydroxide of 33 % strength and was diluted with about 5 liters of water. The precipitated crystalline product was filtered off with suction, washed with water and dried.

Melting point: 54.degree. - 55.degree.C;

Yield: 153 grams of 4-(2'-chloroethoxy)-nitrobenzene.

1 mole of the nitro-compound was reduced, as described by Method A.

Melting point: 66.degree.C;

Yield: 137 grams of 4-(2'-chloroethoxy)-aniline.

All alkoxy-anilines falling under the invention are obtained in accordance with the Methods A - D mentioned above by using in the pertinent examples other corresponding substances in the same molar amounts, instead of the reactants mentioned therein. The following tables give a survey of the preparation and the properties of such amines.

Table 1__________________________________________________________________________Meth- Nitro- and/or b.p./m.p.od acetamino- Reactants (mm) compound [.degree.C]__________________________________________________________________________A CCl.sub.2 =CClH 122 (0.3)A CBr.sub.2 =CBrH 192-196 (3)A CCl.sub.2 =CClH 129-130 (0.4)A ClCF.sub.2 --CCl.sub.2 H 103-108 (0.1)C CF.sub.2 =CCl.sub.2 108 (0.6) (x)A ClCF.sub.2 --CCl.sub.2 H 37-39C CF.sub.2 =CCL.sub.2 133-136 (A)__________________________________________________________________________Meth- Aniline b.p./m.p. Analysisod and/or (mm) calcu- found hydrochloride [.degree.C] lated__________________________________________________________________________A 120-123 6.6% N 6.9% N (1) 34.4% Cl 34.1% ClA 139 4.8% N 4.7% N (0.2) 54.6% Br 54.3% BrA 125-130 6.5% N 6.7% N (0.5) 32.9% Cl 32.7% ClA 44-46 5.8% N 6.0% N 29.3% Cl 29.1% ClC 97 5.8% N 6.0% N (0.3) 29.3% Cl 29.1% ClA 50-51 5.8% N 5.9% N 29.3% Cl 29.5% ClC 111-114 5.5% N 5.6% N (0.3) 27.7% Cl 27.4% Cl__________________________________________________________________________ Table II__________________________________________________________________________Meth- Nitro- and/or b.p./m.p.od acetamino- Reactants (mm) compound [.degree.C]__________________________________________________________________________B Cl--CF.sub.2 --CCl.sub.2 H 98A Cl--CF.sub.2 --CCl.sub.2 36A Cl--CF.sub.2 --CCl.sub.2 95A Cl--CF.sub.2 --CCl.sub.2 45-47 (xx)C CF.sub.2 =CFCl 117 (0 6)C CF.sub.2 =CFCl 105-108 (0 6)C CF.sub.2 =CFCl 108-109 (0 3)__________________________________________________________________________Meth- Aniline b.p./m.p. Analysisod and/or (mm) calcu- found hydrochloride [.degree.C] lated__________________________________________________________________________ 4.8% N 4.6% NB 233 36.4% Cl 36.0% Cl 4.9% N 4.7% NA 135-138 36.7% Cl 36.3% Cl (0.7) 5.1% N 5.8% NA 126-130 38.5% Cl 38.2% Cl (0.5) 5.5% N 5.8% NA 136-140 27.7% Cl 27.9% Cl (0.5) (xx)C 92-93 6.2% N 6.4% N (0.5) 15.7% Cl 15.5% ClC 159-162 5.4% N 5.6% N (14) 27.3% Cl 27.5% ClC 91-93 5.9% N 5.7% N (0.2) 14.8% Cl 14.5% Cl__________________________________________________________________________ Table III__________________________________________________________________________ Nitro-and/or b.p./m.p.Meth- acetamino- Reactants (mm)od compound [.degree.C]__________________________________________________________________________C CF.sub.2 =CFH 86 (0.3)C CF.sub.2 =CFH .fwdarw. (xxx)C CF.sub.2 =CF.sub.2 93 (2)C CF.sub.2 =CF.sub.2 .fwdarw. (xxx)C CF.sub.2 =CF.sub.2 42-44C CF.sub.2 =CF.sub.2 86-88 (0.3)C CF.sub.3 --CF=CF.sub.2 77-79 (0.2)__________________________________________________________________________Aniline b.p./m.p. AnalysisMeth- and/or (mm) calcu-od hydrochloride [.degree.C] lated found__________________________________________________________________________ C 77-79 7.3% N 7.5% N (0.6) 29.8% F 29.1% F 75-76 7.3% N 7.6% NC (0.2) 29.8% F 29.0% F (xxx)C 65 6.7% N 6.8% N (0.2) 36.4% F 36.7% F (xxx)C 87-90 6.7% N 6.6% N (10) 36.4% F 36.5% F (xxx)C 68-70 6.7% N 7.0% N (0.3) 36.4% F 35.8% FC 111 6.3% N 6.5% N (7) 34.1% F 34.5% FC 66 5.4% N 5.6% N (0.15) 44.0% F 43.6% F__________________________________________________________________________ Table IV__________________________________________________________________________ Nitro- and/or b.p./m.p.Meth- acetamino- Reactants (mm)od compound [.degree.C__________________________________________________________________________ ]C CF.sub.3 --CF=CF.sub.2 .fwdarw.C CF.sub.3 --CF=CF.sub.2 74 (0,1)C CF.sub.3 --CF=CF.sub.2 89 (0,2)D 48-50Aniline b.p./m.p. AnalysisMeth- and/or (mm) calcu- foundod hydrochloride [.degree.C] lated__________________________________________________________________________C 73-75 5.4% N 5.7% N (0.3) 44.0% F 43.7% FC 65-67 5.4% N 5.3% N (0.2) 44.0% F 43.8% FC 72-73 5.1% N 4.9% N (0.3) 41.7% F 41.3% FD 62-63 6.8% N 6.5% N 34.5% Cl 34.3% Cl__________________________________________________________________________ (x) Compound described in Ber. 96 (1963) 52; (xx) Compound described in Bull. Soc. Chim. France 5 1957, 581; (xxx) Compound described in J. Org. Chem. 29 (1964) 5;

The novel urea derivatives of the invention are obtained in good yields. They constitute, almost exclusively, crystalline compounds. In most cases they may be used as they are obtained. Further purification by recrystallization from the usual organic solvents is also possible.

The novel compounds have a good action against weeds and are superior to known urea derivatives, for example, the chemically closely related N-(3-chloro-4-methoxyphenyl)-N'-methoxy urea (cf. U.S. Pat. No. 3,228,762) and metobromuron, in their preserving properties for a number of important crop plants such as maize, cotton, and legumes.

They are used in the form of wettable powders, emulsion concentrates, dusting powders or granules, either alone, or, if desired, in combination with other herbicides, soil insecticides or with fertilizers.

Wettable powders are preparations that can be uniformly dispersed in water and contain, besides an inert substance, a wetting agent, for example ethoxylated alkylphenols, ethoxylated oleyl- or stearyl-amines, alkyl- or alkylphenylsulfonates and dispersing agents, for example the sodium salt of ligninsulfonic acid, 2,2'-dinaphthylmethane-6,6'-disulfonic acid, dibutyl-naphthalene-sulfonic acid or sodium oleylmethylraurine.

Emulsion concentrates are obtained by dissolving the active ingredient in an organic solvent, for example butanol, cyclohexanone, dimethyl-formamide, xylene or aromatic hydrocarbons having a higher boiling point. To prepare good suspensions or emulsions in water, wetting agents as specified above are further added.

Dusting powders are obtained by grinding the active ingredients with finely divided solid substances, for example talc, natural clays, pyrophillite or diatomaceous earth.

Granules can be prepared by atomizing the active ingredient on to an absorptive, granulated inert material, or by applying to the surface of granulated inert materials concentrates of the active ingredient with the aid of adhesives, for example polyvinyl alcohol, the sodium salt of polyacrylic acid or mineral oils. Alternatively, suitable active ingredients may be made into granules, if desired in admixture with fertilizers, in the manner commonly used for the manufacture of granulated fertilizers.

The novel compounds of the invention can be used in combination with the following known herbicides enumerated by way of example:urea derivatives linuron, chloroxuron, monlinuron, fluometuron, diurontriazine derivatives simazin, atrazin, ametryne, prometryne, desmetryne, methoprotryneuracil derivatives lenacil, bromacilpyrazone derivatives 1-phenyl-4-amino-5-chloro-pyridazone (6) (PCA)growth-promoting 2,4-dichlorophenoxy-acetic acid (2,4-D)preparations 4-chloro-2-methylphenoxy-acetic acid (MCPA), 2,4,5-trichlorophenoxy-acetic acid (2,4,5-T), 4-chloro-2-methyl- phenoxy-butyric acid (MCPB), 2,3,6- trichlorobenzoic acid (TBA)carbamic acid barban, phenmedipham, triallate,derivatives diallate, vernolate and 2-chloro- allyl-N,N-diethyl-dithiocarbamate (CDEC)dinitrophenol derivatives dinitro-orthocresol (DNOC), di- nitro-sec.-butylphenol (DNBP), dinoseb acetatechlorinated aliphatic acids trichloroacetic acid, dalapon, diphenamide, N,N-diallyl-chloro- acetamide (CDAA)dipyridilium compounds paraquat, biquat, morfamquatanilides N-(3,4-dichlorophenyl)-methacryl- amide (DCMA), propanil, solan, monalidenitriles dichlobenil, ioxynilother preparations flurenol

When the active ingredients according to the invention are mixed with fertilizers, preparations are obtained which simultaneously have a fertilizing and a herbicidal effect.

EXAMPLE 1

Gaseous monomethylamine was introduced into a solution of 0.2 mole (50 grams) of 4-(1',1',2'-trifluoro-2'-chloroethoxy)-phenylisocyanate and 100 milliliters of petroleum ether, at room temperature and while stirring, until the solution was saturated. The reaction mixture was maintained for a further hour at 40.degree.C, cooled, and the crystalline product was filtered off with suction and recrystallized from a large quantity of benzene.

Yield: 41 grams, melting point 150.degree. - 152.degree.C

Analysis: ##SPC4##

N-[4-(1',1',2'-trifluoro-2'-chloroethoxy)-phenyl]-N'-methylurea molecular weight 282.5

calculated 12.6% Cl, 9.9% N; found 12.5% Cl, 10.1% N

EXAMPLE 2

0.1 mole (12 grams) of methylisocyanate was added, at room temperature and while stirring to a solution of 0.2 mole (45 grams) of 4-(1',1',2'-trifluoro-2'-chloro-ethoxy)-aniline in 100 milliliters of absolute benzene. The reaction mixture was then heated for another 2 hours at 40.degree.C. After cooling, the crystalline reaction product was filtered off with suction and recrystallized from a small quantity of n-propanol.

Yield: 35 grams, melting point 148.degree. - 149.degree.C.

The mixed melting point with the compound prepared according to Example 1 did not show a depression.

EXAMPLE 3

0.1 mole (5 grams) of 0-methylhydroxylamine was added at room temperature and with stirring to a solution of 0.1 mole (25 grams) of 4-(1',1',2'-trifluoro-2'-chloro-ethoxy)phenylisocyanate in 120 milliliters of absolute benzene. The reaction mixture was then heated for a further hour at 40.degree.C, cooled, and the crystalline product was filtered off with suction and dried.

Yield: 24 grams, melting point 111.degree. - 112.degree.C.

Analysis: ##SPC5##

N-[4-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenyl]-N'methoxyurea

molecular weight 298.5

calculated 12.0% Cl, 9.4% N; found 12.3% Cl, 9.5% N

EXAMPLE 4

Gaseous dimethylamine was introduced into a solution of 50 grams of 4-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenylisocyanate in 100 milliliters of petroleum ether at room temperature and with stirring until solution was saturated. The reaction mixture was then maintained for a further hour at 40.degree.C, cooled, the crystalline product was filtered off with suction and recrystallized from n-propanol.

Yield: 48 grams, melting point 136.degree. - 138.degree.C

Analysis: ##SPC6##

N-[4-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenyl]-N',N'-dimethylurea

molecular weight 296.5

calculated 12.0 % Cl 9.4 % N found 12.3 % Cl 9.5 % N

EXAMPLE 5

A solution of 0.2 mole (22 grams) of dimethyl-carbamic acid chloride in 25 milliliters of absolute benzene was dropped at 40.degree.C with stirring into a mixture of 0.2 mole (45 grams) of 4-(1',1',2'-trifluoro-2'-chloro-ethoxy)-aniline, 200 milliliters of absolute benzene and 0.2 mole (20 grams) of triethylamine. The reaction mixture was then heated for a further 2 hours at 40.degree.C. After cooling, the reaction product was filtered off with suction, washed with water until it was free from chlorine and recrystallized twice from n-propanol

Yield 38 grams, melting point 135.degree. - 138.degree.C.

The mixed melting point with the compound prepared according to Example 4 did not show a depression.

EXAMPLE 6

0.22 mole (14 grams) of 0,N-dimethylhydroxylamine was added at room temperature and with stirring to a solution of 0.2 mole (50 grams) of 4-(1',1',2'-trifluoro-2'-chloroethoxy)-phenylisocyanate in 100 milliliters of absolute benzene. The reaction mixture was heated for a further hour at 40.degree.C, cooled, and the crystalline product was filtered off with suction and recrystallized from i-propanol.

Yield: 49 grams, melting point 89.degree. - 90.degree.C.

Analysis: ##SPC7##

N-[4-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenyl]-N-methoxy-N'-methylurea

molecular weight 312.5

calculated 9.0 % N, 11.3 % Cl; found 8.8 % N, 11.6 % Cl

EXAMPLE 7

A solution of 0.2 mole (58 grams) of 4-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenylcarbamic acid chloride in 100 milliliters of absolute benzene was dropped at 40.degree.C with stirring into a mixture of 0.2 mole (12 grams) of 0,N-dimethylhydroxylamine, 100 milliliters of absolute benzene and 0.2 mole (20 grams) of triethylamine. The reaction mixture was maintained for a further two hours at 40.degree.C. After cooling, the reaction product was filtered off with suction, washed with water until it was free from chlorine and recrystallized from i-propanol

Yield: 41 grams, melting point 88.degree. - 89.degree.C.

The mixed melting point with the compound prepared according to Example 6 did not show a depression.

EXAMPLE 8

200 milliliters of methanol and 20 milliliters of sodium hydroxide solution of 33 % strength were added to 0.2 mole (60 grams) of N-[4-(1',1',2'-trifluoro-2'-chloro-ethoxy)phenyl]-N'-methoxyurea prepared according to Example 3. While cooling with ice and stirring, 0.22 mole (28 grams) of dimethylsulfate were dropped into the mixture. After stirring for a further hour at 30.degree. - 35.degree.C an excess of water was added, the precipitated reaction product was filtered off with suction, washed with water and recrystallized from i-porpanol. Yield: 45 grams, melting point 87.degree. - 89.degree.C.

The mixed melting point with the compound prepared according to Example 6 did not show a depression.

EXAMPLE 9

0.2 mole (60 grams) of N-[4-(1',1',2'-trifluoro-2'-chloroethoxy)-phenyl]-N'-methyl-N'-hydroxy-urea, obtained by additive reaction of N-methyl-hydroxylamines with the correspondingly substituted phenylisocyanate, were dissolved in 250 milliliters of methanol. 0.22 mole NaOH (20 milliliters of sodium hydroxide solution of 33 % strength) and 0.22 mole (28 grams) of dimethylsulfate were simultaneously added drop by drop while stirring at 40.degree.C to the said solution. The mixture was allowed to react for a further hour at 40.degree.C, an excess of ice water was added, the precipitated reaction product was filtered off with suction and recrystallized twice from i-propanol.

Yield: 38 grams, melting point 86.degree. - 88.degree.C.

The mixed melting point with the compound prepared according to Example 6 did not show a depression.

EXAMPLE 10

300 milliliters of methanol were added to 0.2 mole (57 grams) of N-[4-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenyl]N'-hydroxy-urea. While vigorously stirring at a pH of 9 - 10 and a temperature of 20.degree.C, 50 milliliters of 10N sodium hydroxide solution and 0.5 mole (63 grams) of dimethyl-sulfate were simultaneously poured into the mixture obtained. In the second half of the reaction the pH rose to 10 - 11. The reaction mixture was maintained for another hour at 20.degree.C, then diluted with an excess of ice water. The precipitated reaction product was filtered off with suction, washed with water and recrystallized twice from i-propanol.

Yield: 40 grams, melting point 86.degree. - 88.degree.C.

The mixed melting point with the compound prepared according to Example 6 did not show a depression.

The compounds listed in the following table were prepared in a manner analogous to that of the example indicated in column 3 with the use of the reactants indicated in column 4.

__________________________________________________________________________Ex. Prepara- ReactantsNo. Final product tions molecular weight analogous to Example__________________________________________________________________________ HH11 --N--C--N--CH.sub.3 1 .parallel. O 282.5 HH12 --N--C--N--OCH.sub.3 3 .parallel. O 298.5 CH.sub.3 H13 --N--C--N.angle. 4 .parallel. OCH.sub.3 296.5 OCH.sub.3 H14 --N--C--N.angle. 10 .parallel. OCH.sub.3 312.5 OC.sub.2 H.sub.3 H15 --N--C--N.angle. 6 .parallel. OC.sub.2 H.sub.5 340.5 HH16 --N--C--N--CH.sub.3 2 .parallel. O 296.5 CH.sub.3 H17 --N--C--N.angle. 5 .parallel. OCH.sub.3 310.5 OCH.sub.3 H18 --N--C--N.angle. 6 .parallel. OCH.sub.3 326.5 CH.sub.3 H19 --N--C--N.angle. 4 .parallel. OCH.sub.3 280 OCH.sub.3 H20 --N--C--N.angle. 6 .parallel. OCH.sub.3 296 HH21 --N--C--N--CH.sub.3 1 .parallel. O 266 HCH.sub.322 --N--C--N.angle. 4 .parallel. OCH.sub.3 280 OCH.sub.3 H23 --N--C--N.angle. 10 .parallel. OCH.sub.3 296 HH24 --N--C--N--CH.sub.3 1 .parallel. O 280 CH.sub.325 --N--C--N.angle. 4 .parallel. OCH.sub.3 294 OCH.sub.3 OCH.sub.326 --N--C--N.angle. 8 --N--C--N.angle. .parallel. .parallel. OCH.sub.3 OH 310 CH.sub.3 H27 --N--C--N.angle. 4 .parallel. OCH.sub.3 330 OCH.sub.3 H H28 --N--C--N.angle. 7 --N--CO .parallel. .vertline. OCH.sub.3 Cl 346 CH.sub.3 H29 --N--C--N.angle. 4 .parallel. OCH.sub.3 330 OCH.sub.3 H30 --N--C--N.angle. 10 .parallel. OCH.sub.3 346 CH.sub.3 H H31 --N--C--N.angle. 7 --N--CO .parallel. .vertline. OCH.sub.3 Cl 344 OCH.sub.3 H32 --N--C--N.angle. 6 --NCO .parallel. OCH.sub.3 360 HH -33 --N--C--N--CH.sub.3 1 .parallel. O 248 CH.sub.3 H34 --N--C--N.angle. 4 .parallel. OCH.sub.3 262 OCH.sub.3 H35 --N--C--N.angle. 10 .parallel. OCH.sub.3 278 CH.sub.3 H36 --N--C--N.angle. 4 .parallel. OCH.sub.3 278 CH.sub.3 H37 --N--C--N.angle. 6 .parallel. OOCH.sub.3 357 HH38 --N--C--N--CH.sub.3 1 .parallel. O 327 CH.sub.3 H39 --N--C--N.angle. 4 .parallel. OCH.sub.3 341 OCH.sub.3 H40 --N--C--N.angle. 6 .parallel. OCH.sub.3 357 HH41 --N--C--N--CH.sub.3 2 .parallel. O 341 CH.sub.3 H42 --N--C--N.angle. 4 .parallel. OCH.sub.3 355 OCH.sub.3 H43 --N--C--N.angle. 6 .parallel. OCH.sub.3 355 CH.sub.344 --NH--C--N.angle. 5 .parallel. OCH.sub.3 29845 --NH--C--NH--CH.sub.3 2 .parallel. O 275 CH.sub.346 --NH--C--N.angle. 4 .parallel. OCH.sub.3 289 CH.sub.347 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 30548 --NH--C--NH--CH.sub.3 1 .parallel. O 261 CH.sub.349 --NH--C--N.angle. 5 .parallel. OCH.sub.3 275 CH.sub.350 --NH--C--N.angle. 4 .parallel. OCH.sub.3 323.5 CH.sub.351 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 339.552 --NH--C--NH--CH.sub.3 2 .parallel. O 299 CH.sub.353 --NH--C--N.angle. 4 .parallel. OCH.sub.3 31354 --NH--C--NH--OCH.sub.3 3 .parallel. O 315 CH.sub.355 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 329 C.sub.3 H.sub.7 (n)56 --NH--C--N.angle. 4 .parallel. OC.sub.3 H.sub.7 (n) 39657 2 29958 --NH--C--NH--CH.sub.3 2 .parallel. O 299 CH.sub.359 --NH--C--N.angle. 4 .parallel. OCH.sub.3 31360 --NH--C--NH--OCH.sub.3 3 .parallel. O 315 CH.sub.361 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 32962 --NH--C--NH--CH.sub.3 1 .parallel. O 333.5 CH.sub.363 --NH--C--N.angle. 4 .parallel. OCH.sub.3 347.5 CH.sub.364 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 363.5 C.sub.2 H.sub.565 --NH--C--N.angle. 4 .parallel. OC.sub.2 H.sub.5 375.566 --NH--C--NH--CH.sub.3 2 .parallel. O 261 CH.sub.367 --NH--C--N.angle. 4 .parallel. OCH.sub.3 275 CH.sub.368 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 29169 --NH--C--NH--OCH.sub.3 3 .parallel. O 277 CH.sub.370 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 291 C.sub. 2 H.sub.571 --NH--C--N.angle. 4 .parallel. OC.sub.2 H.sub.5 303 C.sub.4 H.sub.9 (n)72 --NH--C--N.angle. 4 .parallel. OC.sub.4 H.sub.9 (n) 35973 --NH--C--NH--CH.sub.3 2 .parallel. O 309.5 CH.sub.374 --NH--C--N.angle. 4 .parallel. OCH.sub.3 36475 --NH--C--NH--CH.sub.3 2 .parallel. O 362.576 --NH--C--NH--CH.sub.3 2 .parallel. O 275 CH.sub.377 --NH--C--N.angle. 4 .parallel. OCH.sub.3 289 CH.sub.378 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 305 CH.sub.379 --NH--C--N.angle. .parallel. OCH.sub.3 321 CH.sub.380 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 32181 --NH--C--NH--CH.sub.3 2 .parallel. O 295.5 CH.sub.382 --NH--C--N.angle. 4 .parallel. OCH.sub.3 309.5 CH.sub.383 --NH--C--N.angle. 6 .parallel. OOCH.sub.384 --NH--C--NH--CH.sub.3 1 .parallel. O 275 CH.sub.385 --NH--C--N.angle. 4 .parallel. OCH.sub.3 289 CH.sub.386 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 30587 --NH--C--NH--CH.sub.3 2 .parallel. O 31388 --NH--C--NH--OCH.sub.3 3 .parallel. O 329 C.sub.2 H.sub.589 --NH--C--N.angle. 4 .parallel. OC.sub.2 H.sub.5 35590 --NH--C--NH--CH.sub.3 2 .parallel. O 313 CH.sub.391 --NH--C--N.angle. 4 .parallel. OCH.sub.3 327 CH.sub.392 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 343 CH.sub.393 --NH--C--N.angle. 4 .parallel. OCH.sub.3 327 CH.sub.394 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 34395 --NH--C--NH--CH.sub.3 1 .parallel. O 313 CH.sub.396 --NH--C--N.angle. 5 .parallel. OCH.sub.3 327 CH.sub.397 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 34398 --NH--C--NH--CH.sub.3 1 .parallel. O 367 CH.sub.399 --NH--C--N.angle. 4 .parallel. OCH.sub.3 381 CH.sub.3100 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 397101 --NH--C--NH--CH.sub.3 1 .parallel. O 333.5102 --NH--C--NH--OCH.sub.3 3 .parallel. O 349.5 CH.sub.3103 --NH--C--N.angle. 4 .parallel. OCH.sub.3 347.5 CH.sub.3104 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 363.5105 --NH--C--NH--CH.sub.3 1 .parallel. O 333.5 CH.sub.3106 --NH--C--N.angle. 4 .parallel. OCH.sub.3 347.5 CH.sub.3107 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 363.5108 --NH--C--NH--CH.sub.3 1 .parallel. O 333.5 CH.sub.3109 --NH--C--N.angle. 4 .parallel. OCH.sub.3 347.5 CH.sub.3110 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 C.sub.2 H.sub.5111 --NH--C--N.angle. 4 .parallel. OC.sub.2 H.sub.5 375.5112 --NH--C--NH--CH.sub.3 1 .parallel. O 378 CH.sub.3113 --NH--C--N.angle. 4 .parallel. OCH.sub.3 392 CH.sub.3114 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 408 C.sub.2 H.sub.5115 --NH--C--N.angle. 4 .parallel. OC.sub.2 H.sub.5 420116 --NH--C--NH--CH.sub.3 2 .parallel. O 329 CH.sub.3117 --NH--C--N.angle. 4 .parallel. OCH.sub.3 343 CH.sub.3118 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 359119 --NH--C--NH--CH.sub.3 .parallel. O 347.5 CH.sub.3120 --NH--C--N.angle. 4 .parallel. OCH.sub.3 360.5 CH.sub.3121 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 377.5122 --NH--C--NH--CH.sub.3 1 .parallel. O 448 CH.sub.3123 --NH--C--N.angle. 4 .parallel. OCH.sub.3 462 CH.sub.3124 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 478 C.sub.2 H.sub.5125 --NH--C--N.angle. 4 .parallel. OC.sub.2 H.sub.5 490126 --NH--C--NH--CH.sub.3 2 .parallel. O 374.5 CH.sub.3127 --NH--C--N.angle. 4 .parallel. OCH.sub.3 388.5 CH.sub.3128 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 404.5129 --NH--C--NH--CH.sub.3 2 .parallel. O 324.5 CH.sub.3130 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 354.5131 --NH--C--NH--CH.sub.3 1 .parallel. O 228.5 CH.sub.3132 --NH--C--N.angle. 4 .parallel. OCH.sub.3 242.5 CH.sub.3133 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 258.5134 --NH--C--NH--CH.sub.3 1 .parallel. O 228.5 CH.sub.3135 --NH--C--N.angle. 4 .parallel. OCH.sub.3 242.5 CH.sub.3136 --NH-- C--N.angle. 6 .parallel. OOCH.sub.3 258.5137 --NH--C--NH--CH.sub.3 1 .parallel. O 263 CH.sub.3138 --NH--C--N.angle. 4 .parallel. OCH.sub.3 277139 --NH--C--NH--OCH.sub.3 3 .parallel. O 279 CH.sub.3140 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 293141 --NH--C--NH--CH.sub.3 2 .parallel. O 263 CH.sub.3142 --NH--C--N.angle. 4 .parallel. OCH.sub.3 277 CH.sub.3143 --NH--C--N.angle. 8 .parallel. OOCH.sub.3 293 CH.sub.3144 --NH--C--N.angle. 4 .parallel. OCH.sub.3 310.5 CH.sub.3145 --NH--C--N.angle. 10 .parallel. OOCH.sub.3 326.5 CH.sub.3146 --NH--C--N.angle. 5 .parallel. OCH.sub.3 256.5 CH.sub.3147 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 272.5 CH.sub.3148 --NH--C--N.angle. 4 .parallel. OCH.sub.3 256.5 CH.sub.3149 --NH--C--N.angle. 10 .parallel. OOCH.sub.3 272.5150 --NH--C--NH--CH.sub.3 2 .parallel. O 327 CH.sub.3151 --NH--C--N.angle. 4 .parallel. OCH.sub.3 341 CH.sub.3152 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 357 CH.sub.3153 --NH--C--N.angle. 4 .parallel. OCH.sub.3 369 CH.sub.3154 --NH--C--N.angle. 6 .parallel. OOCH.sub.3 385 Ex. Reactants Melting Analysis No. point .degree.C calculated found 11 CH.sub.3 --NH.sub.2 90-92 9.9 % N 10.1 % N 12.6 % Cl 12.6 % Cl 12 H.sub.2 N--OCH.sub.3 82-83 9.4 % N 9.6 % N 11.9 % Cl 12.0 % Cl CH.sub.3 13 HN.angle. 118-121 9.4 % N 9.8 % N CH.sub.3 12.0 % Cl 12.0 % Cl 14 H.sub.2 N--OH, 79-82 9.0 % N 9.1 % N dimethyl sul- 11.3 % Cl 11.2 % Cl fate/ NaOH OC.sub.2 H.sub.5 15 HN.angle. oil 8.2 % N 8.1 % N C.sub.2 H.sub.5 10.4 % Cl 10.1 % Cl 16 CH.sub.3 --NCO 123-125 9.4 % N 9.4 % N 12.0 % Cl 11.7 % Cl H.sub.3 C 17 .angle.N--CO--Cl, 126-128 9.0 % N 8.8 % N H.sub.3 C 11.4 % Cl 11.2 % Cl Triethylamine OCH.sub.3 18 HN.angle. 58-60 8.6 % N 8.6 % N CH.sub.3 10.9 % Cl 11.0 % Cl CH.sub.3 19 HN.angle. 122-123 10.0 % N 10.1 % N CH.sub.3 27.1 % F 27.4 % F OCH.sub.3 20 HN.angle. 67-69 9.5 % N 9.5 % N CH.sub.3 25.6 % F 25.2 % F 21 CH.sub.3 --NH.sub.2 96-98 10.5 % N 10.6 % N 28.6 % F 28.5 % F CH.sub.3 22 HN.angle. 113-115 10.0 % N 10.2 % N CH.sub.3 27.1 % F 27.0 % F 23 H.sub.2 N--OH 57-58 9.5 % N 9.7 % N dimethyl sul- 25.6 % F 25.7 % F fate/NaOH CH.sub.3 24 HN.angle. 129-131 10.0 % N 10.5 % N CH.sub.3 27.1 % F 26.7 % F CH.sub.3 25 HN.angle. 124-126 9.5 % N 9.7 % N CH.sub.3 25.8 % F 25.7 % F 26 dimethylsulfate 61-63 9.0 % N 9.0 % N NaOH 24.5 % F 23.9 % F CH.sub.3 27 HN.angle. 107-108 8.5 % N 8.7 % N CH.sub.3 34.5 % F 34.2 % F OCH.sub.3 28 H.sub.2 N.angle. 50-52 8.1 % N 8.3 % N CH.sub.3 32.9 % F 33.2 % F triethylamine CH.sub.3 29 HN.angle. 98-99 8.5 % N 8.2 % N CH.sub.3 34.5 % F 34.3 % F 30 NH.sub.2 OH 48-49 8.1 % N 8.1 % N dimethylsulfate 33.0 % F 32.7 % F NaOH CH.sub.3 31 HN.angle. 119-120 8.1 % N 8.3 % N CH.sub.3 33.2 % F 32.6 % F triethylamine OCH.sub.3 32 HN.angle. 7.8 % N 8.1 % N CH.sub.3 31.7 % F 31.1 % F 33 H.sub.2 N--CH.sub.3 99-100 11.3 % N 11.3 % N 23.0 % F 23.8 % F CH.sub.3 34 HN.angle. 126-128 10.7 % N 10.7 % N CH.sub.3 21.7 % F 21.0 % F NH.sub.2 OH 35 dimethylsulfate 41-42 10.1 % N 10.4 % N NaOH 20.5 % F 20.0 % F CH.sub.3 36 HN.angle. 138-140 8.2 % N 8.2 % N CH.sub.3 23.4 % Br 23.0 % Br OCH.sub.3 37 HN.angle. 80-82 7.9 % N 8.0 % N CH.sub.3 22.4 % Br 21.9 % Br 38 CH.sub.3 --NH.sub.2 89-91 8.6 % N 8.7 % N 24.4 % F 23.9 % F CH.sub.3 39 HN.angle. 116-117 8.2 % N 8.3 % N CH.sub.3 23.4 % F 23.9 % F OCH.sub.3 40 HN.angle. 88-90 7.9 % N 8.0 % N CH.sub.3 22.4 % F 22.4 % F 41 CH.sub.3 --NCO 128 8.2 % N 8.4 % N CH.sub.3 42 HN.angle. 123-124 7.9 % N 8.2 % N CH.sub.3 22.5 % Br 22.8 % Br OCH.sub.3 43 HN.angle. 58 7.6 % N 7.7 % N CH.sub.3 21.6 % Br 21.8 % Br CH.sub.3 44 .angle.N--CO--Cl 124-126 9.4 % N 9.6 % N CH.sub.3 31.9 % F 31.8 % F triethylamine 45 CH.sub.3 --N=C=O 154-155 10.2 % N 10.3 % N 25.8 % Cl 25.6 % Cl CH.sub.3 46 HN.angle. 103-104 9.7 % N 9.9 % N CH.sub.3 24.6 % Cl 24.3 % Cl CH.sub.3 47 HN.angle. 81-82 9.2 % N 8.9 % N OCH.sub.3 23.2 % Cl 23.1 % Cl 48 CH.sub.3 --N=C=O 145-146 10.7 % N 10.9 % N 27.2 % Cl 27.4 % Cl CH.sub.3 49 Cl--C--N.angle. 153-155 10.2 % N 10.1 % N .parallel. 25.8 % Cl 25.8 % cl OCH.sub.3 CH.sub.3 50 HN.angle. 103-105 8.7 % N 9.0 % N CH.sub.3 33.0 % Cl 32.5 % Cl CH.sub.3 51 HN.angle. 93-94 8.3 % N 8.6 % N OCH.sub.3 31.4 % Cl 31.2 % Cl 52 CH.sub.3 --N=C=O 151 9.4 % N 9.4 % N CH.sub.3 53 HN.angle. 144-146 9.0 % N 9.2 % N CH.sub.3 54 H.sub.2 N--OCH.sub.3 105 8.9 % N 8.7 % N CH.sub.3 55 HN.angle. 60 8.5 % N 8.4 % N OCH.sub.3 C.sub.3 H.sub.7 (n) 56 HN.angle. 103-105 7.6 % N 7.5 % N C.sub.3 H.sub.7 (n) 57 CH.sub.3 --N=C=O 170-173 9.4 % N 9.7 % N 58 CH.sub.3 --N=C=O 104-106 9.4 % N 9.3 % N CH.sub.3 59 HN.angle. 125 8.9 % N 9.0 % N CH.sub.3 60 H.sub.2 N--OCH.sub. 3 100-102 8.9 % N 8.7 % N CH.sub.3 61 HN.angle. 74-76 8.5 % N 8.5 % N OCH.sub.3 62 H.sub.2 N--CH.sub.3 158-159 8.4 % N 8.7 % N 31.9 % Cl 31.5 % Cl CH.sub.3 63 HN.angle. 200-201 8.1 % N 8.2 % N CH.sub.3 CH.sub.3 64 HN.angle. 148-150 7.7 % N 8.0 % N OCH.sub.3 29.3 % Cl 28.9 % Cl C.sub.2 H.sub.5 65 HN.angle. 155-157 7.5 % N 7.4 % N C.sub.2 H.sub.5 66 CH.sub.3 --N=C=O 157-159 10.7 % N 11.1 % N 27.2 % Cl 26.7 % Cl CH.sub.3 67 HN.angle. 105-106 10.2 % N 9.9 % N CH.sub.3 25.8 % Cl 25.2 % Cl CH.sub.3 68 HN.angle. 72-73 9.6 % N 9.6 % N OCH.sub.3 24.4 % Cl 24.0 % Cl 69 H.sub. 2 N--OCH.sub.3 118-120 10.1 % N 10.5 % N 25.6 % Cl 25.1 % Cl CH.sub.3 70 HN.angle. 98-101 9.6 % N 9.3 % N 24.4 % Cl 24.0 % Cl OCH.sub.3 C.sub.2 H.sub.5 71 HN.angle. 110-112 9.2 % N 8.7 % N 23.4 % Cl 23.1 % Cl C.sub.2 H.sub.5 C.sub.4 H.sub.9 (n) 72 HN.angle. 65-68 7.8 % N 7.4 % N 19.7 % Cl 19.9 % Cl C.sub.4 H.sub.9 (n) 73 CH.sub.3 --N=C=O 156-158 9.1 % N 9.2 % N 34.4 % Cl 33.9 % Cl CH.sub.3 74 HN.angle. 158-160 7.7 % N 8.1 % N 43.9 % Br 44.1 % Br CH.sub.3 75 CH.sub.3 --N=C=O 182-184 7.2 % N 7.6 % N 9.8 % Cl 9.9 % Cl 76 CH.sub.3 --N=C=O 156-158 10.2 % N 10.4 % N 25.8 % Cl 25.8 % Cl CH.sub.3 77 HN.angle. 181 9.7 % N 9.7 % N 24.6 % Cl 24.6 % Cl CH.sub.3 CH.sub.3 78 HN.angle. 111-113 9.2 % N 9.0 % N 23.2 % Cl 23.2 % Cl OCH.sub.3 CH.sub.3 79 HN.angle. 171-173 9.2 % N 9.4 % N 23.2 % Cl 23.4 % Cl CH.sub.3 CH.sub.3 80 HN.angle. 85-87 8.7 % N 8.9 % N 22.1 % Cl 22.1 % Cl OCH.sub.3 81 CH.sub.3 --N=C=O 182-186 9.5 % N 9.3 % N 36.0 % Cl 36.0 % Cl CH.sub.3 82 HN.angle. 192-195 9.0 % N 9.3 % N 34.4 % Cl 33.8 % Cl CH.sub.3 CH.sub.3 83 HN.angle. 162-164 8.6 % N 8.8 % N 32.7 % Cl 32.4 % Cl OCH.sub.3 84 H.sub.2 N--CH.sub.3 171-173 10.2 % N 10.0 % N 25.8 % Cl 25.6 % Cl CH.sub.3 85 HN.angle. 192-193 9.7 % N 9.9 % N 24.6 % Cl 24.6 % Cl CH.sub.3 CH.sub.3 86 HN.angle. 126-129 9.2 % N 9.0 % N 23.3 % Cl 23.3 % Cl OCH.sub.3 87 CH.sub.3 --N=C=O 138 8.9 % N 9.0 % N 88 H.sub.2 N--OCH.sub.3 105-106 8.5 % N 8.8 % N C.sub.2 H.sub.5 89 HN.angle. 114-115 7.9 % N 7.9 % N C.sub.2 H.sub.5 90 CH.sub.3 --N=C=O 159-161 8.9 % N 9.2 % N CH.sub.3 91 HN.angle. 95-96 8.6 % N 8.7 % N 21.7 % Cl 21.3 % Cl CH.sub.3 CH.sub.3 92 HN.angle. 71 8.2 % N 8.2 % N OCH.sub.3 CH.sub.3 93 HN.angle. 140 8.6 % N 8.7 % N 21.7 % Cl 21.7 % Cl CH.sub.3 CH.sub.3 94 HN.angle. 79 8.2 % N 8.2 % N 20.7 % Cl 20.6 % Cl OCH.sub.3 95 H.sub.2 N--CH.sub.3 162-163 8.9 % N 9.3 % N CH.sub.3 96 Cl--C--N.angle. 117-119 8.6 % N 8.7 % N .parallel. 21.7 % Cl 21.6 % Cl OCH.sub.3 CH.sub.3 97 HN.angle. 89-91 8.2 % N 8.5 % N OCH.sub.3 98 H.sub.2 N--CH.sub.3 138-140 7.6 % N 7.7 % N CH.sub.3 99 HN.angle. 167-169 7.4 % N 7.1 % N CH.sub.3 CH.sub.3 100 HN.angle. 60-62 7.1 % N 7.3 % N 17.9 % Cl 17.6 % Cl OCH.sub.3 101 H.sub.2 N--CH.sub.3 137-1138 8.4 % N 8.3 % N 32.0 % Cl 31.7 % Cl 102 H.sub.2 N--OCH.sub.3 118 8.0 % N 8.1 % N 30.4 % Cl 29.9 % Cl CH.sub.3 103 HN.angle. 145 8.1 % N 8.2 % N 30.6 % Cl 30.2 % Cl CH.sub.3 CH.sub.3 104 HN.angle. 92-93 7.7 % N 8.0 % N 29.3 % Cl 29.2 % Cl OCH.sub.3 105 H.sub.2 N--CH.sub.3 156-158 8.4 % N 8.6 % N 32.0 % Cl 31.8 Cl CH.sub.3 106 HN.angle. 92-94 8.1 % N 8.0 % N CH.sub.3 CH.sub.3 107 HN.angle. 54-55 7.7 % N 7.9 % N OCH.sub.3 108 H.sub.2 N--CH.sub.3 137-139 8.4 % N 8.6 % N 32.0 % Cl 31.6 % Cl CH.sub.3 109 HN.angle. 115-118 8.1 % N 8.2 % N CH.sub.3 CH.sub.3 110 HN.angle. 96-98 7.7 % N 7.8 % N OCH.sub.3 C.sub.2 H.sub.5 111 HN.angle. 74-76 7.5 % N 7.5 % N C.sub.2 H.sub.5 112 H.sub.2 N--CH.sub.3 157-158 7.4 % N 7.8 % N 21.2 % Br 20.9 % Br CH.sub.3 113 HN.angle. 112 7.2 % N 7.4 % N CH.sub.3 CH.sub.3 114 HN.angle. 94-97 6.9 % N 7.2 % N OCH.sub.3 C.sub.2 H.sub.5 115 HN.angle. 105-106 6.7 % N 6.7 % N C2H5 116 CH.sub.3 --N=C=O 149 8.5 % N 8.6 % N CH.sub.3 117 HN.angle. 159 8.2 % N 8.4 % N CH.sub.3 CH.sub.3 118 HN.angle. 92-93 7.8 % N 8.0 % N OCH.sub.3 119 H.sub.2 N--CH.sub.3 168 8.1 % N 8.3 % N 30.7 % Cl 31.3 % Cl CH.sub.3 120 HN.angle. 145-147 7.8 % N 7.6 % N 29.6 % Cl 29.4 % Cl CH.sub.3 CH.sub.3 121 HN.angle. 105 7.6 % N 7.6 % N 28.2 % Cl 27.9 % Cl OCH.sub.3 122 H.sub.2 N--CH.sub.3 136 6.3 % N 6.6 % N CH.sub.3 123 HN.angle. 128-130 6.1 % N 6.2 % N CH.sub.3 CH.sub.3 124 HN.angle. 69-70 5.9 % N 6.0 % N 29.7 % Cl 29.3 % Cl OCH.sub.3 C.sub.2 H.sub.5 125 HN.angle. 51-53 5.7 % N 5.7 % N C.sub.2 H.sub.5 126 CH.sub.3 --N=C=O 142-144 7.5 % N 7.3 % N 9.5 % Cl 8.9 % Cl CH.sub.3 127 HN.angle. 130-132 7.2 % N 7.3 % N 9.2 % Cl 9.4 % Cl CH.sub.3 CH.sub.3 128 HN.angle. 78-80 6.9 % N 6.9 % N 8.8 % Cl 8.7 % Cl OCH.sub.3 129 CH.sub.3 --N=C=O 150-151 8.6 % N 8.5 % N CH.sub.3 130 HN.angle. 94-97 7.9 % N 7.9 % N 10.0 % Cl 10.0 % Cl OCH.sub.3 131 H.sub.2 N--CH.sub.3 164-166 12.3 % N 12.1 % N CH.sub.3 132 HN.angle. 104-106 11.5 % N 11.8 % N 14.6 % Cl 15.2 % Cl CH.sub.3 CH.sub.3 133 HN.angle. 91-92 10.8 % N 11.1 % N OCH.sub.3 134 H.sub.2 N--CH.sub.3 121 12.3 % N 12.4 % N CH.sub.3 135 HN.angle. 195 11.5 % N 11.4 % N 14.6 % Cl 14.4 % Cl CH.sub.3 CH.sub.3 136 HN.angle. 122 10.8 % N 11.0 % N OCH.sub.3 137 H.sub.2 N--CH.sub.3 102-105 10.6 % N 10.3 % N CH.sub.3 138 HN.angle. 123-125 10.1 % N 10.2 % N 25.6 % Cl 25.8 % Cl CH.sub.3 139 H.sub.2 N--OCH.sub.3 130-131 10.0 % N 10.1 % N 25.4 % Cl 25.3 % Cl CH.sub.3 140 HN.angle. 112-114 9.6 % N 9.6 % N OCH.sub.3 141 CH.sub.3 --N=C=O 154-155 10.6 % N 10.6 % N CH.sub.3 142 HN.angle. 178-179 10.1 % N 9.9 % N 25.6 % Cl 25.4 % Cl CH.sub.3 143 H.sub.2 N--OCH.sub.3 106-108 9.6 % N 9.3 % N dimethylsulfate CH.sub.3 144 HN.angle. 112-114 9.0 % N 9.1 % N 11.4 % Cl 11.6 % Cl CH.sub.3 145 NH.sub.2 OH 108-109 8.6 % N 8.6 % N dimethylsulfate CH.sub.3 146 Cl--C--N.angle. 177-179 10.9 % N 10.9 % N .parallel. 13.8 % Cl 14.2 % Cl OCH.sub.3 CH.sub.3 147 HN.angle. 66-68 10.3 % N 10.3 % N OCH.sub.3 CH.sub.3 148 HN.angle. 116-118 10.9 % N 10.9 % N 13.8 % Cl 14.1 % Cl CH.sub.3 149 NH.sub.2 OH 64-66 10.3 % N 10.1 % N dimethylsulfate 13.0 % Cl 13.3 % Cl 150 CH.sub.3 --N=C=O 120-122 8.6 % N 8.8 % Cl CH.sub.3 151 HN.angle. 159-162 8.2 % N 8.5 % N 20.8 % Cl 20.8 % Cl CH.sub.3 CH.sub.3 152 HN.angle. 58-60 7.9 % N 8.1 % N 19.9 % Cl 19.5 % Cl OCH.sub.3 CH.sub.3 153 HN.angle. 174-175 7.6 % N 7.7 % N 19.2 % Cl 18.9 % Cl CH.sub.3 CH.sub.3 154 HN.angle. 61-63 7.3 % N 7.5 % N OCH.sub.3__________________________________________________________________________

EXAMPLE 155

A wettable powder which is easy to disperse in water was obtained by mixing

80 parts by weight of N-[3-(1',1',2',3',3',3'-hexafluoropropoxy)-phenyl]-N'-, N'--dimethylurea as active ingredient, 17 parts by weight of precipitated silicic acid as inert substance and 3 parts by weight of sodium oleylmethyltaurine as wetting and dispersing agent, and grinding the mixture in a disk attrition mill.

EXAMPLE 156

A dusting powder having good herbicidal properties was obtained by mixing 10 parts by weight of N-[3-methyl-4-(1',1' ,2',2'-tetrafluoroethoxy)-phenyl]-N'-methyl-N'-methoxyurea as active ingredient and 90 parts by weight of talc as inert substance and comminuting the mixture in a cross beater mill.

EXAMPLE 157

An emulsion concentrate was obtained from 15 parts by weight of N-[3-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenyl]N',N'-dimethylurea, 75 parts by weight of cyclohexanone as solvent and 10 parts of nonyl-phenol.10 (ethylene oxide) as emulsifier.

The following comparative examples serve to illustrate the invention but they are not intended to limit it thereto.

COMPARATIVE EXAMPLE 1

In a greenhouse the following weeds

wild mustard Sinapis arvensischickweed Stellaria mediafield camomile Anthemis arvensisbarnyard grass Echinochloa crus-galliannual meadow grass Poa annua and maize and cotton (Gossypium sp.) were sown.

The surface of the soil was sprayed with the following compounds of the invention in the form of wettable powders suspended in water:

I. n-[3-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenyl]-N-methyl-urea (cf. Example 11) Ii. n-[3-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenyl]-N'methyl-N'-methoxy-urea (cf. Example 14) Iii. n-[3-(1',1',2'-trifluoro-2'-chloro-ethoxy)-phenyl]-N',N'dimethyl urea (cf. Example 13).

As comparative substance the known urea herbicide N-(3-chloro-4-methoxyphenyl)-N'-methyl-N'-methoxy-urea IV (cf. U.S. Pat. No. 3,228,762) was used.

An evaluation after 6 weeks with concentrations of 0.6 and 1.2 kilograms of active ingredient per hectare gave the following result:

Degree of Damage in percent______________________________________ I II III IV 0.6 1.2 0.6 1.2 0.6 1.2 0.6 1.2weeds(averageof 5 types) 75 90 93 99 98 100 76 86maize 0 0 0 0 10 20 30 50cotton 0 0 0 0 0 0 60 100______________________________________

The herbicidal effect of substance I of the invention was approximately equal to that of the known comparative compound IV, whereas substances II and III were distinctly superior. Moreover, the novel compounds did almost no harm to the cultivated plants maize and cotton, which were strongly injured and partly destroyed by the comparative compound IV.

With regard to the herbicidal effect and the damage to the specified cultivated plants, the following compounds

a). had an effect similar to that of compound I above

N-[3-methyl-4-(1',1',2',2'-tetrafluoro-ethoxy)-phenyl]-N'-methylurea (cf. Example 24)

N-[3-(1',1',2'-trifluoro-2'-bromo-ethoxy)-phenyl]-N',N'-dimethylurea (cf. Example 39)

N-[3-(1',1',2'-trifluoro-2'-bromo-ethoxy)-phenyl]-N'-methylurea (cf. Example 38)

N-[3-(1',1',2'-trifluoro-2'-bromo-ethoxy)-phenyl]-N'-methyl-N'-methoxyurea (cf. Example 40)

N-[4-(1',1',2',2'-tetrafluoro-ethoxy)-phenyl]-N',N'-dimethylurea (cf. Example 19)

N-[3-(1',1',2'-trifluoro-ethoxy)-phenyl]-N'-methylurea (cf. Example 33) b. had an effect similar to that of compound II above

N-[3-(1',1',2',2'-tetrafluoro-ethoxy)-phenyl]-N'-methylurea (cf. Example 21)

N-[3-methyl-4-(1',1',2',2'-tetrafluoro-ethoxy)-phenyl]-N'-methyl-N'-methoxyurea (cf. Example 26)

N-[3-(1',1',2',3',3',3'-hexafluoro-propoxy)-phenyl]-N',N'-dimethylurea (cf. Example 29)

N-[3-(1',1',2'-trifluoro-ethoxy)-phenyl]-N'-methyl-N'-methoxyurea (cf. Example 35)

c. had an effect similar to that of compound III above

N-[3-(1',1',2',2'-tetrafluoro-ethoxy)-phenyl]-N'-methyl-N'-methoxyurea (cf. Example 23) N-[3-methyl-4-(1',1',2',2'-tetrafluoro-ethoxy)-phenyl]-N'-N'-dimethylurea (cf. Example 25)

N-[3-(1',1',2'-trifluoro-ethoxy)-phenyl]-N',N'-dimethyl-urea (cf. Example 34)

COMPARATIVE EXAMPLE 2

At the same time as the test described above, a comparative test was carried out with horse beans, soybeans (Glycine soya), kidney beans (Phaseolus vulgaris) and maize and the aforesaid weeds, in which test compounds

V. n-[3-(1',1',2',3',3',3'-hexafluoro-propoxy)-phenyl]-N'-methyl-N'-methoxyurea (cf. Example 30) and Vi. n-[4-(1',1',2',3',3',3'-hexafluoro-propoxy)-phenyl]-N',N'-dimethylurea (cf. Example 28) were compared with comparative compound Iv. n-(3-chloro-4-methoxyphenyl)-N'-methyl-N'-methoxyurea.

An evaluation after 6 weeks gave the following result (concentrations 0.6 and 1.2 kilograms of active ingredient per hectare).

______________________________________ Degree of damage in percent V VI IV______________________________________ 0.6 1.2 0.6 1.2 0.6 1.2weeds(averageof 5 types) 90 93 82 88 76 86maize 0 0 0 0 30 50soybean 0 0 0 0 40 95horse bean 0 10 0 0 30 65kidney bean 0 10 0 0 20 50______________________________________

With an approximately equal or slightly superior herbicidal effect, the novel compounds V and VI did no harm to the 4 types of cultivated plants, which were strongly damaged by comparative compound IV.

COMPARATIVE EXAMPLE 3

In a further test, compound

Vii. n-[3-(1',1',2',2'-tetrafluoro-ethoxy)-phenyl]-N',N'-dimethylurea (cf. Example 22) was sprayed in the form of an aqueous suspension on the surface of a soil into which the weeds wild mustard, field camomile, barnyard grass, annual meadow grass and foxtail grass (Amaranthus retroflexus) had been sown together with cotton.

As comparative compound the known urea product metobromuron (VIII), i.e. N-(4-bromophenyl)-N'-methyl-N'-methoxyurea, was used. The result is indicated in the following table. The compounds were used in concentrations of 0.3, 0.6 and 1.2 kilograms per hectare.

______________________________________ Degree of damage in percent VII VIII______________________________________ 0.3 0.6 1.2 0.3 0.6 1.2weeds(averageof 5 types 96 98 100 75 87 94cotton 0 0 0 35 40 75______________________________________

Compound VII of the invention had a distinctly better herbicidal effect than comparative compound VIII and did no harm at all to the cotton, which was considerably damaged by metobromuron.

COMPARATIVE EXAMPLE 4

Seeds of cotton (Gossypium sp.) and various weeds were sown in pots. On the same day wettable powder formulae suspended in water of the preparations

I = n-3-(1',1',2'-trifluoroethoxy)-phenyl-N',N'-dimethylurea (cf. Example 34) Ii = n-3-(1',1',2'-trifluoroethoxy)-phenyl-N'-methyl-N'-methoxyurea (cf. Example 35) Iii = n-3-(1',1',2'-trifluoroethoxy)-phenyl-N'-methylurea (cf. Example 33) were sprayed onto the surface of the soil. As comparative substance, fluometuron (N-3-trifluoro-methylphenyl-N',N'-dimethylurea) was used.

An evaluation 5 weeks after the treatment revealed that cotton was not damaged in any place with amounts of 0.3 and 0.6 kilogram of active ingredient per hectare. With respect to the weeds Sinapis arvensis, Amaranthus retroflexus, Kochia scoparia and Chenopodium album, the effect of the substances in accordance with the invention was about as good as the effect of the comparative substances, i.e. the weeds mentioned above were completely killed everywhere with 0.3 and 0.6 kilogram per hectare. With respect to some other weeds, however, differences were to be seen, which is shown in the following survey.

______________________________________Effect on the weeds, expressed as "degree of damage in %"Species of plant Preparation Effect with 0.3 0.6 kg/ha______________________________________Ipomoea purpurea I 100 100 II 100 100 III 100 100 fluometuron 85 85Datura stramonium I 75 100 II 70 100 III 80 95 fluometuron 30 60Eleusine indica I 100 100 II 95 100 III 95 100 fluometuron 60 85Setaria viridis I 100 100 II 95 100 III 80 100 fluometuron 65 85______________________________________

These values show that the preparations in accordance with the invention have a far better effect on the species of weeds mentioned above than the comparative substance.

COMPARATIVE EXAMPLE 5

In a greenhouse wild mustard and oats were sown in pots. On the day of sowing the soil was treated with a 25 % suspension in water of wettable powders of N-[4-(1',1'-difluoro-2',2'-dichloroethoxy)-phenyl]-N'-methylurea and N-[4-(1',1'-difluoro-2',2'-dichloroethoxy)-phenyl]-N',N'-dimethylurea, respectively.

As comparative substance the known urea herbicide N-(4-chlorophenyl)-N'-methyl-N'-isobutinylurea was used.

The test results are indicated in Table I. In the table are given the amount of active ingredient in kilograms per hectare and the effect of the preparation in "degrees of damage"; "100" means total destruction whereas "0" indicates that the plant was not at all damaged. The figures defined the damage in percent.

An evaluation 6 weeks after the treatment exhibited that in concentrations that are destructive to wild mustard the novel compounds do oats very little harm only. With a 100 % destruction of the wild mustard the oats were damaged to a degree of 10 % only. The corresponding value of the comparative substance amounted to a 75 % destruction of the oats. With a degree of damage of the weed of 70 - 80 %, which is fully satisfactory in practice, the oats were still damaged to about 50 % by the comparative substance, whereas the novel compounds were fully safe. On the other hand the application of double the amount of the herbicidal agent, which is possible in practice at any time, for example with overlapping spray zones on the field, did not noticeably increase the damage of the oat whereas with the comparative substance the damage rose at once to 90 %. Hence, it follows that the application of the novel preparations is much safer.

Table 1__________________________________________________________________________Preparation Test plant Damage with kilograms of active ingredient per hectarecontaining 10 kg/ha 5 kg/ha 2.5 kg/ha 1.2 kg/ha 0.6__________________________________________________________________________ kg/haN--[4-(1',1'-difluoro-2',2'-dichloro-ethoxy)-phenyl]--N'-- wildmethylurea mustard 100 % 100 % 100 % 95 % 75 %N--[4-(1',1'-difluoro-2',2'-dichloro-ethoxy)-phenyl]--N',N'-- " 100 % 100 % 100 % 90 % 70 %dimethylureaN--(4-chlorophenyl)--N'--methyl-- " 100 % 100 % 100 % 100 % 80 %N'--isobutinylureaN--[4-(1',1'-difluoro-2',2'-dichloro-ethoxy)-phenyl]--N'--methylurea oat 10 % 0 % 0 % 0 % 0 %N--[4-(1',1'-difluoro-2',2'-dichloro-ethoxy)-phenyl]--N',N'--dimethylurea " 20 % 10 % 0 % 0 % 0 %N--(4-chlorophenyl)--N'--methyl--N'--isobutinylurea " 100 % 100 % 90 % 75 % 50__________________________________________________________________________ %

COMPARATIVE EXAMPLE 6

Cotton, wild mustard and wild oats were sown in pots in a greenhouse and 3 weeks after germination the pots were treated with an aqueous suspension of N-[4-(1',2'-dichlorovinyloxy)phenyl]-N'-methylurea (preparation I) and a corresponding suspension of N-[4-(1',2'-dichlorovinyloxy)-phenyl]-N',N'-dimethylurea (preparation II), respectively. The respective wettable powders used for the preparation of the aqueous suspensions contained 25 % of active ingredient and 75 % of konwn additives.

As comparative substance N-(3-trifluoromethylphenyl)-N',N'-dimethylurea (preparation III) known as herbicide for cotton cultivations was used.

The results of the comparative test are indicated in Table 2. The results were evaluated 4 weeks after the treatment.

Preparations I and II containing the active ingredients according to the invention had a better effect on wild mustard than comparative substance III. With wild oats the effect of preparation II was almost equal to that of comparative preparation III, while the effect of preparation I was somewhat weaker. However, preparations I and II did less damage to the cotton. In a concentration of 1.2 kilograms/ha, which destroys the wild mustard, preparation III caused a brightening of the cotton leaves while higher concentrations partially involved slight necrosis. In contradistinction thereto, the herbicides according to the invention caused scarcely perceptible damages to the leaves (10 % damage) only in 2 to 4 times higher concentrations.

The above results reveal that when cotton is treated after germination this, crop plant is less damaged by the herbicides according to the invention with an about equal effect on the weeds.

Table 2__________________________________________________________________________Preparation Test plant Damage with kilograms of active ingredient per hectare 5 kg/ha 2.5 kg/ha 1.2 kg/ha 0.6 kg/ha__________________________________________________________________________I Wild mustard 100 % 100 % 100 % 90 %II 100 % 100 % 100 % 100 %III 100 % 100 % 100 % 60 %I Wild oat 75 % 45 % 30 % 30 %II 95 % 75 % 75 % 50 %III 95 % 80 % 75 % 50 %I Cotton 10 % 10 % 0 % 0 %II 10 % 0 % 0 % 0 %III 50 % 40 % 30 % 10 %__________________________________________________________________________Preparation I = N--[4-(1',2'-dichlorovinyloxy)-phenyl]--N'--methylureaPreparation II = N--[4-(1',2'-dichlorovinyloxy)-phenyl]--N',N'--dimethylureaPreparation III = N--(3-trifluoromethyl-phenyl)--N',N'--dimethylurea

COMPARATIVE EXAMPLE 7

In a greenhouse wild mustard, carrots, peas and kidney beans were sown in pots. On the day of sowing the soil was treated with an aqueous suspension of a wettable powder containing as active ingredient N-[4-(3',3'-dichloroallyloxy)-phenyl]-N'-methoxyurea (preparation IV) and N-[4-(3',3'-dichloroallyloxy)-phenyl]-N',N'-dimethylurea (preparation V), respectively. As comparative substance a chemically similar urea derivative was used (cf. U.S. Pat. No. 2,655,447), i.e. N-(4-allyloxyphenyl)-N',N'-dimethylurea (preparation VI). All preparations contained 25 % of active ingredient and 75 % of usual additives in the form of a wettable powder.

The results were evaluated 5 weeks after the treatment. Particulars are indicated in Table 3.

Although all preparations used had about the same herbicidal effect on wild mustard, preparations IV and V according to the invention did much less damage to the three crop plants than comparative preparation VI. The difference was particularly evident with the effect of preparation IV on carrots. In a concentration of 1.2 kilograms/ha, which killed the wild mustard, the carrots did not suffer any damage, while they were substantially destroyed with the same concentration of comparative preparation VI.

Preparation VI substantially saved the kidney beans in the indicated concentration and even with 4 times the concentration the degree of damage was only 30 %. As compared herewith preparation VI when applied in a concentration of 1.2 kilograms/ha caused a slight to distinct damage of 20 to 40 %, whereas too high a concentration, which can never be avoided in practice, injured the plants to an extent of up to 90 % with 5 kilograms per hectare.

It should be stressed that preparation V was particularly safe for peas, whereas the action of preparation IV was a little less favorable. The comparative substance distinctly damaged the peas so that the practical use thereof is unsuitable. In this case, too, it can be seen that the novel herbicides are even tolerated in two to four times the usual concentration.

The above results reveal that with approximately the same herbicidal effect as the comparative substance, the herbicides according to the invention substantially save peas, carrots and kidney beans so that they are excellently suitable for the control of weeds in such crop plants.

Table 3__________________________________________________________________________Test plant Preparation Damage with kg/ha of active ingredient 5 kg/ha 2.5 kg/ha 1.2 kg/ha 0.6 kg/ha 0.3 kg/ha 0.15 kg/ha__________________________________________________________________________Wild mustard IV 100 % 100 % 100 % 95 % 75 % 30 % V 100 % 100 % 100 % 85 % 45 % 20 % VI 100 % 100 % 100 % 90 % 70 % 50 %Carrot IV 40 % 20 % 0 % 0 % 0 % 0 % V 65 % 50 % 50 % 20 % 10 % 10 % VI 100 % 100 % 100 % 80 % 70 % 50 %Pea IV 30 % 30 % 20 % 10 % 0 % 0 % V 20 % 20 % 0 % 0 % 0 % 0 % VI 90 % 80 % 50 % 30 % 20 % 20 %Kidney bean IV 30 % 20 % 0 % 0 % 0 % 0 % V 50 % 30 % 20 % 20 % 0 % 0 % VI 90 % 75 % 40 % 20 % 20 % 10 %__________________________________________________________________________Preparation IV = N--[4-(3',3'-dichloroallyloxy)-phenyl]--N' --methyl--N' --methoxyureaPreparation V = N--[4-(3',3'-dichloroallyloxy)-phenyl] --N',N' --dimethylureaPreparation IV = N--(4-allyloxyphenyl)--N',N' --dimethylurea

COMPARATIVE EXAMPLE 8

The dicotyledonous weeds

wild mustard Sinapis arvensis chickweed Stellaria media field camomile Anthemis arvensisand the monocotyledonous Alopecurus myosuroides weed annual blackgrass

and the crop plants

pea Pisum sativum horse bean Vicia faba spring wheat Triticum aestivum spring rye Secale cereale spring barley Hordeum distichumand cotton Gossypium sp. were sown in big plastics boxes filled with containing lummus sandy loam and the boxes were covered. On the day of sowing the surface of the soil was treated with an aqueous suspension of a wettable powder containing as active ingredient N-[3-(1',1'-difluoro-2',2'-dichloroethoxy)-phenyl]-N',N'-dimethylurea (preparation VII) or N-[3-(1',1'-difluoro-2',2'-dichloroethoxy)-phenyl-N'-methoxy-N'-methylurea (preparation VIII), respectively. As comparative substances various urea compounds and a triazine derivative were used, chosen according to the crop plants, namely: N-3,4-dichlorophenyl-N'-methyl-N'-methoxyurea (linuron) (preparation IX) and 2-chloro-4,6-bis-ethylamino-s-triazine (simazin) (preparation X) for pea, horse bean and the cereals, N-4-chlorophenyl-N'-methyl-N'-isobutinylurea (buturon)

(preparation XI)

for the cereals, N-3-trifluoromethylphenyl-N',N'-dimethylurea (fluometuron) (preparation XII) and N-3,4-dichlorophenyl-N',N'-dimethylurea (diuron) (preparation XIII) for cotton.

The boxes were placed in a hotbed and the results were evaluated 5 weeks after the treatment.

Table 4 shows that preparations VII and VIII according to the invention have, on the average, approximately the same effect on weeds as the indicated comparative substances, particularly on the dicotyledonous weeds. But also the annual blackgrass still suffers a distinct damage. The destructive concentration for most of the weeds is about 0.6 kilogram of active ingredient per hectare for all preparations, i.e. the novel herbicides as well as the comparative substances.

Table 4__________________________________________________________________________ Damage with kg/ha of active ingredientAmount applied Test plant Test plantPreparation 0.15 kg/ha 0.6 kg/ha 2.5 kg/ha 0.15 kg/ha 0.6 kg/ha 2.5__________________________________________________________________________ kg/haVII Wild 70 % 100 % 100 % Chickweed 90 % 100 % 100 %VIII mustard 60 % 100 % 100 % 70 % 100 % 100 %IX 90 % 100 % 100 % 100 % 100 % 100 %X 80 % 100 % 100 % 90 % 100 % 100 %XI 50 % 70 % 100 % 70 % 100 % 100 %XII 60 % 100 % 100 % 90 % 100 % 100 %XIII 50 % 80 % 100 % 80 % 100 % 100 %VII Field 60 % 100 % 100 % Annual blackgrass 30 % 60 % 90 %VIII camomile 50 % 90 % 100 % 10 % 40 % 80 %IX 80 % 100 % 100 % 30 % 60 % 80 %X 60 % 100 % 100 % 50 % 80 % 100 %XI 70 % 100 % 100 % 60 % 80 % 100 %XII 80 % 100 % 100 % 10 % 40 % 60 %XIII 80 % 100 % 100 % 30 % 60 % 80__________________________________________________________________________ %

Table 5 shows, however, that the novel herbicides are distinctly safer for some crop plants than the comparative substances. Pea, horse bean as well as cotton were not damaged or damaged to a very small extent only by 0.6 kilogram per hectare of the preparations according to the invention, whereas the same amount of the corresponding comparative substances injured the specified plants to a lesser or greater extent. The selectivity was especially pronounced when surplus amounts were applied as is relatively often the case in practice. With 4 times the normal concentration, that is to say 2.5 kilograms per hectare, the horse bean exhibited some damage whereas cotton and pea remained practically undamaged. The comparative substances caused much more serious damage, above all preparations IX and X on the pea. Even 16 times the concentration (10 kg/ha) of the novel compounds hardly damaged cotton and pea, whereas the same concentrations of the comparative substances strongly injured the cotton and completely destroyed the pea.

Moreover, under practical conditions preparation VII had a much better selectivity in cultivations of various cereals (wheat, rye, barley) than the comparative substances.

Table 5__________________________________________________________________________Amount applied Test plant: pea Test plant: horse bean Test plant: cottonpreparation 0.15 0.6 2.5 10.0 0.15 0.6 2.5 10.0 0.15 0.6 2.5 10.0 kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha__________________________________________________________________________VII 0 % 0 % 10 % 30 % 0 % 20 % 50 % 90 % 0 % 0 % 0 % 10 %VIII 0 % 0 % 10 % 30 % 0 % 0 % 20 % 50 % 0 % 0 % 10 % 20 %IX 0 % 20 % 60 % 100 % 0 % 40 % 70 % 100 %X 0 % 30 % 60 % 100 % 0 % 20 % 60 % 100 %XII 0 % 10 % 30 % 50 %XIII 0 % 10 % 30 % 60__________________________________________________________________________ % Test plant: wheat Test plant: rye Test plant: barley 0.15 0.6 2.5 10.0 0.15 0.6 2.5 10.0 0.15 0.6 2.5 10.0 kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha kg/ha__________________________________________________________________________VIII 0 % 0 % 20 % 40 % 0 % 0 % 30 % 60 % 0 % 0 % 20 % 30 %IX 0 % 30 % 70 % 100 % 10 % 50 % 90 % 100 % 0 % 10 % 30 % 70 %X 20 % 70 % 90 % 100 % 0 % 50 % 80 % 100 % 30 % 70 % 100 100 %XI 10 % 50 % 70 % 100 % 0 % 40 % 90 % 100 % 0 % 30 % 70 % 100__________________________________________________________________________ %

COMPARATIVE EXAMPLE 9

In the same manner as in Comparative Example 8 the substances

N-[3-(1',1'-difluoro-2',2'-dichloroethoxy)-phenyl]-N'-methoxyurea (preparation XIV) and N-[3-(1',1'-difluoro-2',2'-dichloroethoxy)-phenyl-N'-methylurea (preparation XV) were tested as to their effect on wild mustard, chickweed, pea, spring wheat and spring barley and additionally on oats Avena sativasorghum millet Sorghum milletmaize Zea mayskidney bean Phaseolus vulgaris

Table 6 shows that the novel herbicides XIV and XV exhibted a good effect on dioctyledonous weeds such as wild mustard and chickweed, and did not injur a series of crop plants. Even when applied in double the concentration they caused at most a minor damage, if any.

Table 6__________________________________________________________________________Damage with kilograms active ingredient per hectareAmount applied Test plant: wild mustard Test plant: chickweed Test plant: peapreparation 1.2 kg/ha 2.5 kg/ha 5 kg/ha 1.2 kg/ha 2.5 kg/ha 5 kg/ha 1.2 kg/ha 2.5 5__________________________________________________________________________ kg/haXIV 70 % 100 % 100 % 70 % 100 % 100 % 0 % 0 % 20 %XV 90 % 100 % 100 % 100 % 100 % 100 % 0 % 0% 20__________________________________________________________________________ % Test plant: oat Test plant: barley Test plant: wheat 1.2 kg/ha 2.5 kg/ha 5 kg/ha 1.2 kg/ha 2.5 kg/ha 5 kg/ha 1.2 kg/ha 2.5 5__________________________________________________________________________ kg/haXIV 0 % 0 % 20 % 0 % 0 % 10 % 0 % 0 % 10 %XV 0 % 0 % 30 % 0 % 0 % 0 % 0 % 0 % 0__________________________________________________________________________ % Test plant: sorghum millet Test plant: maize Test plant: bean 1.2 kg/ha 2.5 kg/ha 5 kg/ha 1.2 kg/ha 2.5 kg/ha 5 kg/ha 1.2 kg/ha 2.5 5__________________________________________________________________________ kg/haXIV 0 % 0 % 0 % 0 % 0 % 10 % 0 % 20 % 40 %XV 0 % 0 % 0 % 0 % 0 % 0 % 0 % 0 % 20__________________________________________________________________________ %

COMPARATIVE EXAMPLE 10

In a field test on loamy soil peas and horse beans were treated on the day of sowing with an aqueous suspension of

N-[4-(2'-chloroethoxy)-phenyl]-N',N'-dimethylurea (XVI) N-[4-(2'-chloroethoxy)-phenyl]-N'-methyl-N'-methoxyurea (XVII) N-[4-(2'-chloroethoxy)-phenyl]-N'-methylurea (XVIII), respectively. Each plot had a size of 20 square meters. Each suspension was applied to 4 plots. The comparative substance was a urea preparation comprising of N-[4-(p-chlorophenoxy)-phenyl]-N',N'-dimethylurea (chloroxuron, XIX) often, used for various vegetable cultivations.

The data of the evaluation 8 weeks later by visual inspection are calculated to give the degree of damage in percent.

As weeds the following dicotyledonous types were present:

chickweed Stellaria mediashepherd's purse Capsella bursa-pastorisdead nettle Lamium amplexicaulegroundsel Senecio vulgariswild mustard sinapis arvensis andknotweed Polygonum aviculare

The results of the evaluation of these types are indicated. As monocotyledonous weed annual blackgrass (Alopercurus myosuroides) was present.

Table 7 shows that the action on dioctyledonous weeds of two of the substances according to the invention, namely XVI and XVII, was slightly superior to that of comparison substance XIX, while the action of the third compound XVIII was approximately equal to that of the latter. The novel herbicides had, however, a distinctly better effect on the often difficult to handle annual blackgrass. Moreover, the results indicate that all three novel preparations were less harmful to the pea, whereas at least two of the three compounds, namely XVI and XVIII, were distinctly safer for the horse bean than the comparative substance.

The advantage of the compounds according to the invention is therefore based on the fact that they are safer for peas and horse beans than known herbicides and, moreover, that they control more effectively weedy grasses such as annual blackgrass.

Table 7__________________________________________________________________________ Degree of damage with kilogram of active ingredient per hectareAmount applied Test plant 1.25 kg/ha 2.5 kg/ha 5.0 kg/ha Test plant 1.25 kg/ha 2.5 kg/ha 5.0 kg/hapreparation__________________________________________________________________________XVI Dicotylous 90 % 98 % 100 % Pea 0 % 10 % 20 %XVII weed 90 % 98 % 100 % 0 % 0 % 10 %XVIII 60 % 73 % 95 % 0 % 0 % 10 %XIX 65 % 85 % 98 % 20 % 30 % 40 %XVI Annual blackgrass 60 % 80 % 90 % Horse 0 % 10 % 10 %XVII 60 % 70 % 80 % bean 0 % 10 % 30 %XVIII 40 % 50 % 60 % 0 % 0 % 0 %XIX 0 % 20 % 30 % 0 % 20 % 30__________________________________________________________________________ %

COMPARATIVE EXAMPLE 11

In a hotbed the following compounds

N-[3-chloro-4-(1',1'-difluoro-2',2'-dichloroethoxy)-phenyl]-N'-methylurea (preparation I) N-[3-chloro-4-(1',1'-difluoro-2',2'-dichloroethoxy)-phenyl]-N',N'-dimethylurea (preparation II) and N-[3-chloro-4-(1',1'-difluoro-2',2'-dichoroethoxy)-phenyl]-N'-methyl-N'-methoxyurea (III) were tested as to their herbicidal effect and safety in a series of crop plants. The seeds of the following weeds wild mustard Sinapis arvensischickweed Stellaria mediafield camomile Anthemis arvensisgroundsel Senecio vulgaris and the following crop plants pea Pisum sativumhorse bean Vicia fabakidney bean Phaseolus vulgariscarrot Daucus carotaspring rye Secale cerealespring barley Hordeum distichumspring wheat Triticum aestivumoats Avena sativamaize Zea maysrice Oryza sativa andcotton Gossypium sp. were sown in boxes filled with sandy loom containing humus. The surface of the soil was sprayed on the same day with aqueous suspensions of the specified preparations. After 5 weeks the plants were classified by visual inspection and the values obtained were calculated to give the degree of damage in percent. As comparative substances the following compounds were used: for cotton: N-3,4-dichlorophenyl-N',N'-dimethylurea (diuron, IV) for the vegetables: N-4-(p-chlorophenoxy)-phenyl-N',N'-dimethylurea (chloroxuron, V) for the cereals: N-4-chlorophenyl-N'-methyl-N'-methoxyurea (monolinuron, VI)

Table 8 shows that the compounds according to the invention I, II and III have approximately the same effect on the germinating dicotyledonous weeds as the known comparative substances. The concentration sufficient for a normal control of the weeds is, in general, in the range of from 0.6 to 1.2 kilograms of active ingredient per hectare.

Table 9 indicates, however, that the novel herbicides are safer for the crop plants. Compounds I and II are safer for cotton, pea, horse bean and kidney bean, compound II is safer for the carrot and all three novel compounds are safer for the cereals than the comparative substances. Even when applied in a surplus concentration, the novel compounds only invove little damage.

Hence, it follows that the compounds according to the invention are distinctly safer, above all for cotton and kidney beans, furthermore for rye, oats, maize and a series of other crop plants, than are the corresponding comparative substances.

Table 8__________________________________________________________________________ Degree of damage with kilograms of active ingredient per hectareAmount applied Test plant 0.6 kg/ha 1.2 kg/ha 5.0 kg/ha Test plant 0.6 kg/ha 1.2 kg/ha 5.0 kg/hapreparation__________________________________________________________________________I Wild mustard 50 % 60 % 95 % Chick weed 70 % 85 % 100 %II 80 % 95 % 100 % 100 % 100 % 100 %III 80 % 90 % 90 % 90 % 90 % 100 %IV 80 % 100 % 100 % 100 % 100 % 100 %V 60 % 80 % 90 % 70 % 80 % 100 %VI 75 % 90 % 100 % 90 % 100 % 100 %I Field camomile 70 % 85 % 95 % Groundsel 80 % 90 % 100 %II 80 % 95 % 100 % 90 % 100 % 100 %III 60 % 70 % 100 % 80 % 90 % 95 %IV 90 % 100 % 100 % 100 % 100 % 100 %V 75 % 85 % 100 % 70 % 80 % 95 %VI 80 % 95 % 100 % 90 % 100 % 100__________________________________________________________________________ % Table 9__________________________________________________________________________Action on cultivated plantsAmount applied Test plant 0.6 kg/ha 1.2 kg/ha 5.0 kg/ha Preparation Test plant 0.6 kg/ha 1.2 kg/ha 5.0 kg/hapreparation__________________________________________________________________________I Cotton 0 % 0 % 0 % I Carrots 0 % 10 % 40 %II 0 % 0 % 0 % II 0 % 0 % 10 %IV 10 % 30 % 40 % V 0 % 20 % 40 %Preparation Test plant: pea Test plant: horse bean Test plant: kidney bean 0.6 kg/ha 1.2 kg/ha 5.0 kg/ha 0.6 kg/ha 1.2 kg/ha 5.0 kg/ha 0.6 kg/ha 1.2 kg/ha 5.0__________________________________________________________________________ kg/haI 0 % 0 % 10 % 0 % 0 % 10 % 0 % 0 % 0 %II 0 % 0 % 20 % 0 % 0 % 30 % 0 % 0 % 0 %V 10 % 30 % 40 % 20 % 20 % 40 % 0 % 20 % 55 %Preparation Test plant: rye Test plant: barley Test plant: wheat 0.6 kg/ha 1.2 kg/ha 5.0 kg/ha 0.6 kg/ha 1.2 kg/ha 5.0 kg/ha 0.6 kg/ha 1.2 kg/ha 5.0__________________________________________________________________________ kg/haI 0 % 0 % 0 % 0 % 0 % 20 % 0 % 0 % 0 %II 0 % 0 % 30 % 0 % 20 % 25 % 0 % 0 % 10 %III 0 % 0 % 30 % 0 % 30 % 40 % 0 % 0 % 20 %VI 30 % 80 % 100 % 30 % 60 % 90 % 40 % 70 % 100 %Preparation Test plant: oat Test plant: maize Test plant: rice 0.6 kg/ha 1.2 kg/ha 5.0 kg/ha 0.6 kg/ha 1.2 kg/ha 5.0 kg/ha 0.6 kg/ha 1.2 kg/ha 5.0__________________________________________________________________________ kg/haI 0 % 0 % 10 % 0 % 0 % 0 % 0 % 0 % 10 %II 0 % 0 % 10 % 0 % 0 % 10 % 0 % 10 % 20 %III 0 % 0 % 0 % 0 % 0 % 0 % 0 % 20 % 30 %VI 30 % 60 % 100 % 20 % 30 % 50 % 30 % 50 % 90__________________________________________________________________________ %

COMPARATIVE EXAMPLE 12

N-[3-methyl-4-(1',1'-difluoro-2',2'-dichloroethoxy)-phenyl]-N'-methyl-N'-methoxyurea (VII), N-[3-methyl-4-(1',1'-difluoro-2',2'-dichloroethoxy)-phenyl]-N',N'-dimethylurea (VIII), N-4-chlorophenyl-N'-methyl-N'-methoxyurea (monolinuron, IX) N-4-chlorophenyl-N'-methyl-N'-isobutinylurea (buturon, X) mixed product of 5 % of 2-chloro-3,6-bisethylamino-s-triazin (simazin) and 22.5 % of 2-methylmercapto-4isopropylamino-6-(3'-methoxy)-propylamino-s-triazine (XI) were tested as follows:

The weeds

wild mustard Sinapis arvensischickweed Stellaria mediafield camomile Anthemis arvensisfat hen Chenopodium album and the crop plants spring wheat Triticum aestivumspring barley Hordeum distichumoats Avena sativarice Oryza sativasugar beet Beta vulgaris andhorse bean Vicia faba were sown in boxes filled with sandy loam containing humus. On the same day the surface of the soil was sprayed with an aqueous suspension of preparations VII and VIII. As comparative substances two urea compounds often used for cereals (XI and X) and a mixed triazine product also suitable for cereals were used. Comparative product IX is also suitable for horse beans.

Afer the treatment the boxes were placed in a hotbed and kept therein for 6 weeks until the test was evaluated. Table 10 shows that the novel compounds VII and VIII had about the same action on weeds as the comparative substances. With an amount applied of 1.2 kilograms per hectare of active ingredient, the latter killed all weeds whereas the same amount of the novel compounds strongly damaged the weeds and a higher amount fully destroyed the weeds.

Table 10______________________________________ Degree of damage on weeds withPreparation 0.6 kg/ha 1.2 kg/ha 2.5 kg/ha______________________________________VII 54 % 73 % 100 %VIII 76 % 89 % 100 %IX 92 % 99 % 100 %X 92 % 100 % 100 %XI 90 % 100 % 100 %______________________________________

The indicated values are average values for all four types of weeds:

The following Table 11 reveals, however, that with an amount of 1.2 kg/ha the comparative substances strongly or very strongly injured the cereals mentioned, whereas the novel compounds saved completely or almost completely or almost completely wheat, barely, oat and rice in an amount of 1.2 and 2.5 kg/ha. Furthermore, the horse bean was not or only slightly damaged by the novel compounds, whereas comparative substance IX strongly damaged this type of plant. Novel substance VII saved the sugar beet when applied in the indicated amount, whereas all comparative substances destroyed the beet almost completely.

The novel compounds have the advantage that in an amount sufficient to destroy or strongly injure a series of important field weeds they save numerous crop plants such as wheat, barely, oats, rice and horse bean, partially also sugar beet, whereas comparative substances often used for the indicated cultivations exhibit a much stronger damaging action.

Table 11__________________________________________________________________________ Action on crop plants Test plant: wheat Test plant: barley Test plant: oatPreparation 0.6 kg/ha 1.2 kg/ha 2.5 kg/ha 0.6 kg/ha 1.2 kg/ha 2.5 kg/ha 0.6 kg/ha 1.2 kg/ha 2.5__________________________________________________________________________ kg/haVII 0 % 0 % 0 % 0 % 0 % 0 % 0 % 0 % 0 %VIII 10 % 10 % 20 % 0 % 0 % 30 % 0 % 0 % 10 %IX 20 % 50 % 95 % 20 % 40 % 50 % 40 % 80 % 100 %X 65 % 80 % 90 % 55 % 95 % 100 % 60 % 90 % 100 %XI 85 % 90 % 100 % 70 % 90 % 100 % 80 % 85 % 100__________________________________________________________________________ % Test plant: rice Test plant: sugar beet Test plant: horse beanPreparation 0.6 kg/ha 1.2 kg/ha 2.5 kg/ha 0.6 kg/ha 1.2 kg/ha 2.5 kg/ha 0.6 kg/ha 1.2 kg/ha 2.5__________________________________________________________________________ kg/haVII 0 % 0 % 0 % 0 % 0 % 20 % 0 % 0 % 0 %VIII 0 % 0 % 0 % 100 % 100 % 100 % 0 % 10 % 20 %IX 80 % 95 % 100 % 95 % 100 % 100 % 50 % 60 % 80 %X 40 % 55 % 70 % 100 % 100 % 100 %XI 70 % 80 % 90 % 100 % 100 % 100 %__________________________________________________________________________

COMPARATIVE EXAMPLE 13

In a greenhouse the following weeds

wild mustard Sinapis arvensischickweed Stellaria mediafield camomile Anthemis arvensisbarnyard grass Echinochloa crus-galliannual meadow grass Poa annua and the crop plants maize Zea mayswheat Triticum sativumhorse bean Vicia fabapea Pisum sativumcarrot Daucus carota were sown in boxes filled with sandy loam containing humus. On the same day the surface of the soil was sprayed with wettable powders suspended in water of the following compounds of the invention I. n-[3-chloro-4-(2'-chloroethoxy)-phenyl]-N',N'-dimethyl-urea (cf. Example 138) and Ii. n-[3-trifluoromethyl-4-(2'-chloroethoxy)-phenyl]-N',N'-dimethyl-urea (cf. Example 144)

As comparative substance the known urea derivative fluometuron = N-3-trifluoromethylphenyl-N',N'-dimethyl-urea was used.

An evaluation after 6 weeks with concentrations of 0.3 and 0.6 kilogram of active ingredient per hectare gave the following results:

______________________________________Degree of damage in percent(100 = complete destruction - 0 = no damage) comparative I II substance 0.3 0.6 0.3 0.6 0.3 0.6______________________________________weeds(average of5 types) 90 100 92 99 92 99maize 0 0 0 0 20 60wheat 0 0 0 0 40 70horse bean 0 0 0 0 60 90pea 0 0 0 0 25 70carrot 0 10 0 0 30 50______________________________________

The novel compounds and the comparative substance showed an excellent herbicidal effect. The novel compounds did no harm to the crop plants maize, wheat, horse bean, pea and carrot, which plants were strongly or very strongly injured by the comparative substance.

COMPARATIVE EXAMPLE 14

In a further test and in the same manner as described in comparative Example 1, the five types of weeds and as crop plants maize and cotton (Gossypium sp.) were sown. The surface of the soil was sprayed with a wettable powder suspended in water and containing as active ingredient

Iii. n-[3-chloro-4-(2'-chloroethoxy)-phenyl]-N'-methyl-N'-methoxy-urea (cf. Example 140).

As comparative substance the chemically closely related urea herbicide

N-(3-chloro-4-methoxyphenyl)-N'-methyl-N'-methoxy-urea was used.

An evaluation after 6 weeks with concentration of 0.6 and 1.2 kilograms of active ingredient per hectate gave the following result:

Degree of damage in percent III comparative substance 0.6 1.2 0.6 1.2______________________________________weeds (average of5 types) 80 96 76 86maize 0 0 30 50cotton 0 10 60 100______________________________________

The herbicidal effect of compound III was approximately equal to that of the comparative substance but the novel compound did no harm to the crop plants maize and cotton which were strongly damaged and partly even destroyed by the comparative substance.

COMPARATIVE EXAMPLE 15

In boxes filled with sandy loam sandy loam containing humus, spring wheat (Triticum aestivum) and spring barley (Hordeum distichum) were sown together with the weeds wild oat (Avena fatua) and various broad-leaved types (Sinapis arvensis, Stellaris media, Galium aparine, Anthemis arvensis, Veronica arvensis and Polygonum persicaria). On the same day the surface of the soil was sprayed with aqueous suspensions of the compounds of the invention

Iv. n-[3-methyl-4-(2'-chloroethoxy)-phenyl]-N',N'-dimethyl-urea (cf. Example 148) and V. n-[3-methyl-4-(2'-chloroethoxy)-phenyl]-N'-methyl-N'-methoxy-urea (cf. Example 149) As comparative compound the triazine derivatives known as herbicide for cereals

2-methylmercapto-4-ethylamino-6-tert.butyl-amino-s-triazine was used.

The evaluation after 5 weeks with concentrations of 0.6 kilogram of active ingredient per hectare gave the following result:

Degree of damage in percent(100 = complete destruction 0 = no damage)type of plant IV V comparative substance______________________________________wheat 10 0 0barley 0 0 0weedswild oat 100 100 20other weeds(average value) 94 86 92______________________________________

The table shows that all preparations had a good or very good action against broad-leaved weeds and did no harm to cereals. But the very troublesome wild oat, which is difficult to combat, was not damaged by the known herbicide for cereals whereas the compounds of the invention destroyed the wild oat without doing any harm to the botanically closely related cereals wheat and barely.

Claims

1. A compound of the formula ##SPC8##

wherein R.sub.1 is haloalkyl having 2 to 5 carbon atoms, the halogen being selected from the group consisting of fluorine, chlorine, and bromine; n.sub.1 is 1 or 2; R.sub.2 is hydrogen or alkyl having 1 to 4 carbon atoms; R.sub.3 is alkyl having 1 to 4 carbon atoms; R.sub.4 is halogen, trifluoromethyl, or alkyl or alkoxy having 1 to 3 carbon atoms; and n.sub.2 is 0, 1, 2, or 3.

2. A compound having the formula ##SPC9##