Claims
- 1. A method for treatment of an addictive, compulsive disorder caused by alcohol or cocaine abuse, which comprises the administration to a human or animal suffering from such a disorder, an effective amount of the compound of the formula: in which R is hydrogen or alkyl of 1-6 carbon atoms;R1 is hydrogen or one or two substituents selected from the halogens, alkoxy of 1 to 3 carbon atoms, CF3 or alkyl of 1-6 carbon atoms; and R2 is hydrogen, methyl or ethyl; or a pharmaceutically acceptable salt thereof.
- 2. A method of treatment for cocaine abuse according to claim 1.
- 3. The method according to claim 1, wherein the compound is (±)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 4. The method according to claim 1, wherein the compound is (±)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 5. The method according to claim 1, wherein the compound is (+)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 6. The method according to claim 1, wherein the compound is (±)-1-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 7. The method according to claim 1, wherein the compound is (+)-1-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 8. The method according to claim 1, wherein the compound is (±)-1-phenyl-3-azabicyclo[3.1.0]hexane hydrochloride.
- 9. The method according to claim 1, wherein the compound is (±)-1-(3-bromo-4-methoxyphenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 10. The method according to claim 1, wherein the compound is (±)-1-(4-fluorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 11. A method for treatment of cocaine abuse according to claims 3, 4, 5, 6, 7, 8, 9 or 10.
- 12. A method for treatment of drug dependence caused by alcohol or cocaine abuse, which comprises administering to a human or animal suffering from or dependent on a drug, an effective amount of the compound of the formula: in which R is hydrogen or alkyl of 1-6 carbon atoms;R1 is hydrogen or one or two substituents selected from the halogens, alkoxy of 1 to 3 carbon atoms, CF3 or alkyl of 1-6 carbon atoms; and R2 is hydrogen, methyl or ethyl; or a pharmaceutically acceptable salt thereof.
- 13. A method of treatment of dependence on cocaine according to claim 12.
- 14. The method according to claim 12, wherein the compound is (±)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 15. The method according to claim 12, wherein the compound is (±)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 16. The method according to claim 12, wherein the compound is (+)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 17. The method according to claim 12, wherein the compound is (±)-1-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 18. The method according to claim 12, wherein the compound is (+)-1-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 19. The method according to claim 12, wherein the compound is (±)-1-phenyl-3-azabicyclo[3.1.0]hexane hydrochloride.
- 20. The method according to claim 12, wherein the compound is (±)-1-(3-bromo-4-methoxyphenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 21. The method according to claim 12, wherein the compound is (±)-1-(4-fluorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride.
- 22. A method of treatment of dependence on cocaine according to claims 14, 15, 16, 17, 18, 19, 20, or 21.
- 23. A method for treatment of an addictive, compulsive disorder caused by alcohol abuse, which comprises the administration to a human or animal suffering from such a disorder, an effective amount of the compound of the formula: in which R is hydrogen or alkyl of 1-6 carbon atoms;R1 is hydrogen or one or two substituents selected from the halogens, alkoxy of 1 to 3 carbon atoms, CF3 or alkyl of 1-6 carbon atoms; and R2 is hydrogen, methyl or ethyl; or a pharmaceutically acceptable salt thereof.
- 24. The method of claim 23 in which said compound is selected from the group consisting of:(±)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane; (±)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane; (+)-1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane; (±)-1-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexane; (+)-1-(4-chlorophenyl)-3-azabicyclo[3.1.0]hexane; (±)-1-phenyl-3-azabicyclo[3.1.0]hexane; (±)-1-(3-bromo-4-methoxyphenyl)-3-azabicyclo[3.1.0]hexane; and (±)-1-(4-fluorophenyl)-3-azabicyclo[3.1.0]hexane; or a pharmaceutically acceptable salt thereof.
Parent Case Info
This application is a continuation of application Ser. No. 08/122,856 filed Sep. 16, 1993, now abandoned, which is a continuation of Ser. No. 07/811,418, filed Dec. 20, 1991 now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4435419 |
Epstein et al. |
Mar 1984 |
|
Non-Patent Literature Citations (1)
Entry |
Amit et al., J. Clin. Psychiatry, 52:12(suppl), Dec. 1991. |
Continuations (2)
|
Number |
Date |
Country |
Parent |
08/122856 |
Sep 1993 |
US |
Child |
08/414180 |
|
US |
Parent |
07/811418 |
Dec 1991 |
US |
Child |
08/122856 |
|
US |