Use of 1,5-dimethyl-8-hydroximino-bicyclo[3.2.1]octane as perfuming ingredient

Abstract

Process for imparting, enhancing or modifying the odorous note in perfumes, perfume compositions, artificial essential oils, flavoring agents or flavor compositions to a "blackcurrant" note, which comprises adding thereto 1.5-dimethyl-8-hydroximino-bicyclo[3.2.1]octane ##STR1## Wherein the wavy line denotes geometric isomers, at a concentration of at least 1 part per million by weight based on the total weight of the thus obtained material.

Description

THE INVENTION

The present invention relates to the field of perfumery and flavoring, in particular it relates to a process for imparting, enhancing or modifying the odorous note in perfumes, perfume compositions, artificial essential oils, flavoring agents or flavor compositions to a "blackcurrant" note, which comprises adding thereto 1.5-dimethyl-8-hydroximino-bicyclo[3.2.1]octane (2) at a concentration of at least 1 part per million by weight based on the total weight of the thus obtained material.

The invention provides a perfume and flavoring composition or an artificial essential oil containing as active perfuming ingredient a compound of formula 2. The invention provides also an artificial essential oil of the "blackcurrant" type or "Cassis bourgeous" which comprises having added thereto a compound of formula 2.

Compound 2 is produced according to a known per se method by reacting 1.5-dimethyl-bicyclo[3.2.1]octane-8-one (1) with hydroxylamine in the presence of a strong base, preferably sodium or potassium acetate or sodium or potassium hydroxide. The production of the ketone 1 and the oxime 2 are described in DE-OS 2 945 812. Nothing was known about olfactory or gustatory properties of the oxime 2 ##STR2##

BACKGROUND OF THE INVENTION

The expensive "Cassis bourgeous" and, to a greater extent, buchu leaf oil, the essential oil of barosma betulina (Bartl. & Wendl.) have been in use in the perfume and flavoring industry for many years. This oil is available in varying qualities and amounts, but always at a relatively high price. The interesting fragrance complex of buchu leaf oil, with fresh sweet and green-herby notes and a very typical "blackcurrent" character, has prompted various study groups to analyse the oil (E. Sundt, B. Wilhalm, R. Chappaz and G. Ohloff, Helv. Chim. Acta 54, 1801 (1971); D. Lamparsky and P. Schudel, Parfums, Mosm/e/ t. Savons Fr. 2, 465 (1972)). In particular, these revealed that menthon-thiol is the carrier of the "blackcurrent" note. Menthon-thiol is shown in patents (D. Lamparsky and P. Schudel, DT-OS No. 2 043 341, E. Sundt and G. Ohloff, CH-PS No. 543 584).

In the field of perfumery, only a limited number of oximes of aliphatic aldehydes or ketones with 7-10 carbon atoms are known (R. T. Dahill, U.S. Pat. No. 3,637,533, Jan. 25, 1972; i.e. DT-PS No. 1,692,002). These aldehydes and ketones (e.g. 2-methyl-2-hepten-6-one, citronellal) are common fragrance chemicals with fruity or citrus notes. The scent of the associated oximes differs from this and has been characterised as "green-leafy", "green-earthy" "flowery".

PREFERRED EMBODIMENTS OF THE INVENTION

No particular olfactory properties are known for the oximes of mono- or polycyclic ketones. It is thus surprising and novel that the newly produced compound 2 has an intense fresh, fruity-green fragrance with a distinct "blackcurrent" note. This was particularly surprising in view of the fact that the ketone 1 and the ketals thereof merely posses herbal, earthy notes. The special olfactory properties of compound 2 make it very suitable for use as a perfuming agent or constituent of perfume oils.

Compound 2 can also be used as a flavoring agent or a constituent of flavoring compositions.

The results of sensory evaluation were:

______________________________________Minimum detectable amount 0.2 ppm (in sugar water)Minimum quantifiable amount 0.9 ppmFlavor evaluation sweet, dark-fruity, blackcurrent fuller and less fresh than buchu leaf oilFlavor intensity approx. 50% of buchu leaf oil approx. 5% of menthon-thiol______________________________________ The compound (2) in the invention is produced by reacting 1.5-dimethyl-bicyclo[3.2.1]octane-8-one (1) by a known method with hydroxylamine in the presence of strong bases, preferably sodium or potassium hydroxide or sodium or potassium acetate. Reaction preferably takes place at elevated temperature: a temperature up to the boiling point of the reaction medium may be used. However the preferred temperature lies in the range 50.degree. C. to 75.degree. C. The substance is prepared and isolated according to the usual methods used in industrial organic chemistry. The oxime 2 obtained in this way has a different melting point and IR data to the material described in DE-OS No. 2 945 812.

The invention is better illustrated by but not limited to the following examples:

EXAMPLE 1

Preparation of 1.5-dimethyl-8-hydroximino-bicyclo[3.2.1]octane (2)

At 60.degree. C., 91.2 g (0.6 mole) of 1.5-dimethyl-bicyclo[3.2.1]octane-8-one (1) was dripped into a solution of 78.7 g (0.6 mole) hydroxylamin hydrogensulfate and 54.2 g (0.66 mole) sodium acetate in 135 g water. This was stirred for 1 h at 60.degree. C. and then allowed to cool to room temperature and sodium extracted with ether. The combined organic phases were neutralized by washing with a saturated solution of chloride, dried and concentrated by evaporation. 95 g (95%) 2 crystalline solid is obtained. By crystallising 9 g of the raw product from 15 ml ethanol, 8 g 2 are obtained having a m.p. of 129.degree.-130.degree. C. IR: 3400, 3250, 1685, 930 cm.sup.-1 (oxim). NMR (CCl.sub.4): .delta.=1.05, s (--CH.sub.3, transoid to --C.dbd.N--OH), 1.43, s (--CH.sub.3, cisoid to -- C.dbd.N--OH), 9.03 ppm (--C.dbd.N--OH). MS: m/z (%)=167 (M.sup.+, 2%), 150(85), 133(15), 123(17), 108(23), 93(100). C.sub.10 H.sub.17 ON (M: 167.24)

EXAMPLE 2

______________________________________Perfume oil with oriental note______________________________________Galbanum oil (10%) 5 gVanillin (10%) 20 gp-hydroxyphenylbutanon-3 (10%) 30 gMaltol (1%) 5 gCivet natural (3%) 20 gUndecylenaldehyd (10%) 30 gCyclohexyl oxy acetic acid allyl ester 30 gAmbergris tincture (5%) 10 gMandarine oil, Italian 15 gBergamot oil, Reggio 30 gBenzyl acetate 30 gPhenyl ethyl alcohol 30 gCitronellol 10 gOil of roses, Bulgarian 10 gRose de Mai, absolue 10 gHydroxycitronellol 50 gCedryl acetate 150 gVetiveryl acetate 70 gPatchouli oil, Singapore 150 gCoumarin 10 gMusk ketone 50 gBenzyl salicylate 85 gIso eugenol methyl ether 20 gYlang-Ylang oil 20 gCoriander oil 10 gStyrolyl acetate 10 gTarragon oil 5 gBenzoe Siam Resinoid 20 gOak moss, Jugoslavia 10 gLabdanum extract 5 gMethyl ionone, gamma 50 gStyrax extract 10 galpha-methyl cinnamaldehyde 30 g 1108 g______________________________________ The above perfume oil has an oriental fragrance with flowery, woody notes. Flowery-fruity notes are emphasised by adding 20 parts of compound 2, and the composition is complemented as desired by a buchu note, which is otherwise only achieved to some extent by means of "Cassis bourgeous".

Compound 2 may be used as odorant in pure form. As component of perfume oils or flavor compositions the usual concentration is 0.001 to 30%, preferably 0.1 to 20%. All percent given are percents by weight.

Claims

1. Process for imparting, enhancing or modifying the odorous note of a material selected from the group consisting of perfumes and perfume compositions by imparting a blackcurrant note, which comprises adding thereto a 1,5-dimethyl-8-hydroximinobicyclo3,2,1octane, at a concentration of at least 1 part per million by weight based on the total weight of the thus obtained material.

2. Process according to claim 1, wherein the compound is used in an amount of at least 10 parts per million.

3. A process as defined in claim 1 wherein the material is a perfume.

4. A process as defined in claim 1 wherein the material is a perfume composition.