Claims
- 1) A process for the preparation of a compound of the formula (II)
- 2) A method of treating an illness, which involves an abnormal production of nitric oxide (NO) by induction of an inducible NO-synthase (NOS-2), comprising administering to a patient in need of such a treatment a therapeutically effective amount of a compound of formula (I):
- 3) The method according to claim 2, wherein the compound of formula (I) is chosen from the following compounds:
4-(morpholin-4-ylmethyl)-4,5-dihydro-1,3-thiazol-2-ylamine, 4-(piperazin-1-ylmethyl)-4,5-dihydro-1,3-thiazol-2-ylamine, and 4-(4-methyl-piperazin-1-ylmethyl)-4,5-dihydro-1,3-thiazol-2-ylamine, or a racemic mixture, an enantiomer, a diastereoisomer or a mixture thereof, or a tautomer thereof, or a pharmaceutically acceptable salt thereof.
- 4) The method according to claim 2, wherein the compound of formula (I) is 4-(4-methyl-piperazin-1-ylmethyl)-4,5-dihydro-1,3-thiazol-2-ylamine or a racemic mixture, an enantiomer, or a tautomer thereof, or a pharmaceutically acceptable salt thereof.
- 5) The method according to claim 2, wherein the illness is selected from the group consisting of multiple sclerosis, cerebral, focal or global ischemia, cerebral or spinal trauma, Parkinson's disease, Huntington's disease, Alzheimer's disease, amyotrophic lateral sclerosis, migraine, depression, schizophrenia, anxiety and epilepsy.
- 6) The method according to claim 2, wherein the illness is Parkinson's disease.
- 7) The method according to claim 2, wherein the illness is caused by inflammatory components.
- 8) The method according to claim 2, wherein the illness is caused by the growth of a tumor.
Priority Claims (1)
Number |
Date |
Country |
Kind |
0114510 |
Nov 2001 |
FR |
|
Parent Case Info
[0001] This application is a Continuation of U.S. application Ser. No. 10/291,084, filed Nov. 8, 2002, which claimed the benefit of U.S. Provisional Application No. 60/352,797, filed Jan. 30, 2002, and which claimed the benefit of priority of French Patent Application No. 01/14,510, filed Nov. 9, 2001.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60352797 |
Jan 2002 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
10291084 |
Nov 2002 |
US |
Child |
10764853 |
Jan 2004 |
US |