TREA

Use of anthranilic acid diamide derivatives for pest control in transgenic crops

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Information

  • Patent Grant
  • 9414595
  • Patent Number
    9,414,595
  • Date Filed
    Monday, December 17, 2012
    11 years ago
  • Date Issued
    Tuesday, August 16, 2016
    8 years ago
Information
Abstract
The present invention relates to the use of anthranilic acid diamide derivatives with heteroaromatic and heterocyclic substituents of formula (I)
Description
BACKGROUND

1. Field of the Invention


The present invention relates to the use of anthranilic acid diamide derivatives for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and to methods particularly useful for controlling insects, and/or acarids and/or nematodes and/or increasing crop yield in those crops.


2. Description of Related Art


It is already known that certain anthranilamides (e.g. WO 01/70671, WO 03/015519, WO 03/016284, WO 03/015518, WO 03/024222, WO 03/016282, WO 03/016283, WO 03/062226, WO 03/027099, WO 04/027042, WO 04/033468, WO 2004/046129, WO 2004/067528, WO 2005/118552, WO 2005/077934, WO 2005/085234, WO 2006/023783, WO 2006/000336, WO 2006/040113, WO 2006/111341, WO 2007/006670, WO 2007/024833, WO 2007/020877) are useful for combating harmful pests which occur in agriculture.


However, environmental and economic requirements imposed in modern-day crop protection agents are continually increasing. This is particularly true with regard to the spectrum of action, toxicity, selectivity, application rate, and formation of residues. Additionally, when applying agrochemicals, there are always the problems with resistances. Thus, there is a constant need for developing new, alternative methods which in some areas at least help to fulfil the abovementioned requirements. Also, as concerns regarding a possible impact of agrochemicals on the environment and the health of humans and animals are growing in the public opinion, efforts have to be made to reduce the amount of agrochemicals applied.


The inventors now surprisingly found that specific anthranilic diamide derivatives can advantageously be used for controlling harmful pests, such as insects and/or acarides and/or nematodes on selected transgenic crops and thus satisfying above mentioned needs. The inventors even found that a synergistic activity increase occurs by applying selected anthranilic diamide derivatives on selected transgenic crops and that crop yield on those crops is increased.


SUMMARY

Thus, the invention is directed to the use of anthranilic acid diamide derivatives with heteroaromatic and heterocyclic substituents of formula (I)




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in which

  • R1 represents hydrogen, amino or hydroxyl or represents C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C3-C6-cycloalkyl each of which is unsubstituted or substituted one or more times by identical or different substituents selectable independently of one another from halogen, cyano, nitro, hydroxyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, (C1-C4-alkoxy)carbonyl, C1-C4-alkylamino, di(C1-C4-alkyl)amino, C3-C6-cycloalkylamino or (C1-C4-alkyl)C3-C6-cycloalkylamino,
  • R2 represents hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C1-C4-alkylamino, di(C1-C4-alkyl)amino, C3-C6-cycloalkylamino, C2-C6alkoxycarbonyl or C2-C6-alkylcarbonyl,
  • R3 represents hydrogen or represents C1-C6-alkyl, C1-C6-alkoxy, C2-C6-alkenyl, C2-C6-alkynyl each of which is optionally substituted one or more times by identical or different substituents selectable independently of one another from halogen, cyano, nitro, hydroxyl, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-C4-alkylsulphimino, C1-C4-alkylsulphimino-C1-C4-alkyl, C1-C4-alkylsulphimino-C2-C5-alkylcarbonyl, C1-C4-alkylsulphoximino, C1-C4-alkylsulphoximino-C1-C4-alkyl, C1-C4-alkylsulphoximino-C2-C5-alkylcarbonyl, C2-C6-alkoxycarbonyl, C2-C6-alkylcarbonyl or C3-C6-trialkylsilyl,
  • R3 further represents C1-C6-alkyl, C1-C6-alkoxy, C2-C6-alkenyl, C2-C6-alkynyl each of which is optionally substituted one or more times by identical or different substituents selectable independently of one another from amino, C3-C6-cycloalkylamino or a 5- or 6-membered heteroaromatic ring,
  • R3 likewise further represents C3-C12-cycloalkyl, C3-C12-cycloalkyl-C1-C6-alkyl and C4-C12-bicycloalkyl, the substituents being selectable independently of one another from halogen, cyano, nitro, hydroxyl, amino, C1-C6-alkyl, C3-C6-cycloalkyl, C3-C6-cycloalkylamino, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-C4-alkylsulphimino, C1-C4-alkylsulphimino-C1-C4-alkyl, C1-C4-alkylsulphimino-C2-C5-alkylcarbonyl, C1-C4-alkylsulphoximino, C1-C4-alkylsulphoximino-C1-C4-alkyl, C1-C4-alkylsulphoximino-C2-C5-alkylcarbonyl, C2-C6-alkoxycarbonyl, C2-C6-alkylcarbonyl, C3-C6-trialkylsilyl or a 5- or 6-membered heteroaromatic ring,
  • R2 and R3 can be joined to one another via two to six carbon atoms and form a ring which where appropriate additionally contains a further nitrogen, sulphur or oxygen atom and where appropriate may be substituted one to four times by C1-C2-alkyl, halogen, cyano, amino or C1-C2-alkoxy,
  • R2 and R3 further together represent ═S(C1-C4-alkyl)2 or ═S(O)(C1-C4-alkyl)2,
  • R4 represents hydrogen, halogen, cyano, nitro, C1-C4-alkyl, C1-C4-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C1-C4-alkoxy, C1-C4-haloalkoxy, SF5, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-C4-haloalkylthio, C1-C4-haloalkylsulphinyl, C1-C4-haloalkylsulphonyl, C1-C4-alkylamino, di(C1-C4-alkyl)amino, C3-C6-cycloalkylamino, (C1-C4-alkoxy)imino, (C1-C4-alkyl)(C1-C4-alkoxy)imino, (C1-C4-haloalkyl)(C1-C4-alkoxy)imino or C3-C6-trialkylsilyl, or
  • two R4s, via adjacent carbon atoms, form a ring which represents —(CH2)3—, —(CH2)4—, —(CH2)5—, —(CH═CH—)2—, —OCH2O—, —O(CH2)2O—, —OCF2O—, —(CF2)2O—, —O(CF2)2O—, —(CH═CH—CH═N)— or —(CH═CH—N═CH)—,
  • two R4s further, via adjacent carbon atoms, form the following fused rings, which where appropriate are substituted one or more times by identical or different substituents selectable independently of one another from hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C3-C6-halocycloalkyl, halogen, C1-C6-alkoxy, C1-C4-alkylthio(C1-C6-alkyl), C1-C4-alkylsulphinyl(C1-C6-alkyl), C1-C4-alkylsulphonyl(C1-C6-alkyl), C1-C4-alkylamino, di(C1-C4-alkyl)amino or C3-C6-cycloalkylamino,




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  • n represents 0 to 3,

  • R5 represents C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C1-C6-halocycloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-C4-haloalkylthio, C1-C4-haloalkylsulphinyl, C1-C4-haloalkylsulphonyl, halogen, cyano, nitro or C3-C6-trialkylsilyl,

  • R6 represents hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C2-C6-haloalkenyl or





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  • R6 further represents C3-C6-cycloalkoxy,

  • R7 represents independently at each occurrence hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, halogen, cyano, nitro, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio or C1-C4-haloalkylthio,

  • m represents 0 to 4,

  • X represents N, CH, CF, CCl, CBr or CI,

  • A represents —CH2—, —CH2O—, —CH2OCH2—, —CH2S—, —CH2SCH2—, —CH2N(C1-C6-alkyl)-, —CH2N(C1-C6-alkyl)CH2—, —CH[CO2(C1-C6-alkyl)]-, —CH(CN)—, —CH(C1-C6-alkyl)-, —C(di-C1-C6-alkyl)-, —CH2CH2— or —C═NO(C1-C6-alkyl)-,

  • Q represents a 5- or 6-membered heteroatomatic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system, the ring system being unsubstituted or substituted one or more times by identical or different substituents selectable independently of one another from hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C3-C6-halocycloalkyl, halogen, CN, CO2H, CO2NH2, NO2, OH, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-C4-haloalkylthio, C1-C4-haloalkylsulphinyl, C1-C4-haloalkylsulphonyl, C1-C4-alkylamino, di(C1-C4-alkyl)amino, C3-C6-cycloalkylamino, (C1-C6-alkyl)carbonyl, (C1-C6-alkoxy)carbonyl, (C1-C6-alkyl)aminocarbonyl, di(C1-C4-alkyl)aminocarbonyl, tri(C1-C2-alkyl)silyl and (C1-C4-alkyl)(C1-C4-alkoxy)imino,

  • Q further represents a 5- or 6-membered heteroaromatic or heterocyclic ring or an aromatic 8-, 9- or 10-membered fused heterobicyclic ring system, the ring or the ring system being unsubstituted or substituted one or more times by identical or different substituents selectable independently of one another from hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C3-C6-halocycloalkyl, halogen, CN, CO2H, CO2NH2, NO2, OH, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-C4-haloalkylthio, C1-C4-haloalkylsulphinyl, C1-C4-haloalkylsulphonyl, C1-C4-alkylamino, di(C1-C4-alkyl)amino, C3-C6-cycloalkylamino, (C1-C6-alkyl)carbonyl, (C1-C6-alkoxy)carbonyl, (C1-C6-alkyl)aminocarbonyl, di(C1-C4-alkyl)aminocarbonyl, tri(C1-C2-alkyl)silyl and (C1-C4-alkyl)(C1-C4-alkoxy)imino,
    • or the substituents being selectable independently of one another from phenyl or a 5- or 6-membered heteroaromatic ring, it being possible for phenyl or the ring to be unsubstituted or substituted one or more times by identical or different C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C3-C6-halocycloalkyl, halogen, CN, NO2, OH, C1-C4-alkoxy, C1-C4-haloalkoxy substituents,



whereas the compounds of the general formula (I) also encompass N-oxides and salts,


for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and to methods particularly useful for controlling insects, and/or acarids and/or nematodes and/or increasing crop yield in those crops.


Accordingly, the present invention also relates to the use of compositions comprising a compound of the general formula (I) for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and/or increasing crop yield in those crops.


Accordingly, the present invention also relates to the use of compositions comprising


A) a compound of the general formula (I) and


B) at least one further agrochemically active compound,


for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and/or increasing crop yield in those crops.


An exemplary method of the invention comprises applying a compound of the general formula (I) of the invention to either soil or a plant (e.g., seeds or foliarly) for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and/or increasing crop yield in those crops.


The present invention is drawn to compositions and methods for regulating pest resistance or tolerance in plants or plant cells. By “resistance” is intended that the pest (e.g., insect or nematode) is killed upon ingestion or other contact with the plant or parts thereof. By “tolerance” is intended an impairment or reduction in the movement, feeding, reproduction, or other functions of the pest. Methods for measuring pesticidal activity are well known in the art. See, for example, Czapla and Lang (1990) J. Econ. Entomol. 83:2480-2485; Andrews et al. (1988) Biochem. J. 252:199-206; Marrone et al. (1985) J. of Economic Entomology 78:290-293; and U.S. Pat. No. 5,743,477, all of which are herein incorporated by reference in their entirety.


In conjunction with the present invention “controlling” denotes a preventive or curative reduction of the insect or nematode infestation in comparison to the untreated crop, more preferably the infestation is essentially repelled, most preferably the infestation is totally suppressed.


By “pesticidally-effective amount” is intended an amount of the pesticide that is able to bring about death to at least one pest, or to noticeably reduce pest growth, feeding, or normal physiological development. This amount will vary depending on such factors as, for example, the specific target pests to be controlled, the specific environment, location, plant, crop, or agricultural site to be treated, the environmental conditions, and the method, rate, concentration, stability, and quantity of application of the pesticidally-effective polypeptide composition.


The present invention also relates to a method for the protection of seed and germinating plants, or plant from attack by pests, by selectively applying pesticidal agents to the seed of a transgenic plant. Pesticidal agents include chemical or biological control agents compositions applied to the seed of the transgenic plant, wherein the agent is intended to provide protection of the plant or seed thereof against damage caused by one or more plant pests. Furthermore, the invention relates to seed which has been treated with a pesticidal agent as described herein. Application of a pesticidal agent to the seed of a transgenic plant results in an improved resistance or tolerance to one or more plant pests and/or improved yield or vigor compared to a transgenic plant cultivated from a seed not treated with a pesticidal agent as described herein, or a plant of the same species as the referenced transgenic plant that has been cultivated from a seed treated with a pesticidal agent as described herein but that lacks the transgene (either of which may be herein referred to as a “control” plant).


In some embodiments, treatment of the seed with these agents not only protects the seed itself, but also the resulting plants after emergence, from pests. In this manner, the immediate treatment of the crop at the time of sowing or shortly thereafter can be dispensed with.







DETAILED DESCRIPTION OF A PREFERRED EMBODIMENT

Preferred radical definitions for the formula (I) given above are specified below.

  • R1 preferably represents hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, cyano(C1-C6-alkyl), C1-C6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C1-C4-alkylsulphinyl-C1-C4-alkyl or C1-C4-alkyl-sulphonyl-C1-C4-alkyl.
  • R1 more preferably represents hydrogen, methyl, cyclopropyl, cyanomethyl, methoxymethyl, methylthiomethyl, methylsulphinylmethyl or methylsulphonylmethyl.
  • R1 very preferably represents hydrogen.
  • R2 preferably represents hydrogen or C1-C6-alkyl.
  • R2 more preferably represents hydrogen or methyl.
  • R2 very preferably represents hydrogen.
  • R3 preferably represents hydrogen or represents C1-C6-alkyl, C1-C6-alkoxy, C2-C6-alkenyl or C2-C6-alkynyl each of which is unsubstituted or substituted one or more times by identical or different substituents selectable from halogen, cyano, nitro, hydroxyl, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-C4-alkylsulphimino, C1-C4-alkylsulphimino-C1-C4-alkyl, C1-C4-alkylsulphimino-C2-C5-alkylcarbonyl, C1-C4-alkylsulphoximino, C1-C4-alkylsulphoximino-C1-C4-alkyl, C1-C4-alkylsulphoximino-C2-C5-alkylcarbonyl, C2-C6-alkoxycarbonyl, C2-C6-alkylcarbonyl or C3-C6-trialkylsilyl,
  • R3 further preferably represents C3-C12-cycloalkyl and C4-C10-bicycloalkyl, the substituents being selectable independently of one another from halogen, cyano, nitro, hydroxy, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-C4-alkylsulphimino, C1-C4-alkylsulphimino-C1-C4-alkyl, C1-C4-alkylsulphimino-C2-C5-alkylcarbonyl, C1-C4-alkylsulphoximino, C1-C4-alkylsulphoximino-C1-C4-alkyl, C1-C4-alkylsulphoximino-C2-C5-alkylcarbonyl, C2-C6-alkoxycarbonyl, C2-C6-alkylcarbonyl or C3-C6-trialkylsilyl,
  • R3 more preferably represents hydrogen or represents C1-C6-alkyl, C1-C6-alkoxy each of which is unsubstituted or substituted one or more times by identical or different substituents selectable independently of one another from halogen, cyano, nitro, hydroxyl, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-C4-alkylsulphimino, C1-C4-alkylsulphimino-C1-C4-alkyl, C1-C4-alkylsulphimino-C2-C5-alkylcarbonyl, C1-C4-alkylsulphoximino, C1-C4-alkyl-sulphoximino-C1-C4-alkyl, C1-C4-alkylsulphoximino-C2-C5-alkylcarbonyl, C2-C6-alkoxy-carbonyl, C2-C6-alkylcarbonyl or C3-C6-trialkylsilyl,
  • R3 further more preferably represents C3-C6-cycloalkyl which is unsubstituted or substituted one or more times by identical or different substituents selectable independently of one another from halogen, cyano, nitro, hydroxyl, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-4-alkylsulphimino, C1-C4-alkylsulphimino-C1-C4-alkyl, C1-C4-alkylsulphimino-C2-C5-alkylcarbonyl, C1-C4-alkylsulphoximino, C1-C4-alkylsulphoximino-C1-C4-alkyl, C1-C4-alkylsulphoximino-C2-C5-alkylcarbonyl, C2-C6-alkoxycarbonyl, C2-C6-alkylcarbonyl or C3-C6-trialkylsilyl,
  • R3 very preferably represents C1-C4-alkyl (methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl) or cyano-C1-C3-alkyl (cyanomethyl, 1-cyanoethyl, 2-cyanoethyl, 1-cyano-n-propyl, 2-cyano-n-propyl, 3-cyano-n-propyl, 1-cyanoisopropyl, 2-cyanoisopropyl).
  • R3 with particular preference represents methyl, isopropyl or cyanomethyl.
  • R4 preferably represents hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, halogen, cyano, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio or C1-C4-haloalkylthio.
    • Preferably, moreover, two adjacent radicals R4 represent —(CH2)3—, —(CH2)4—, —(CH2)5—, —(CH═CH—)2—, —OCH2O—, —O(CH2)2O—, —OCF2O—, —(CF2)2O—, —O(CF2)2O—, —(CH═CH—CH═N)— or —(CH═CH—N═CH)—.
  • R4 more preferably represents hydrogen, C1-C4-alkyl, C1-C2-haloalkyl, halogen, cyano or C1-C2-haloalkoxy.
    • More preferably, moreover, two adjacent radicals R4 represent —(CH2)4—, —(CH═CH—)2—, —O(CH2)2O—, —O(CF2)2O—, —(CH═CH—CH═N)— or —(CH═CH—N═CH)—.
  • R4 very preferably represents hydrogen, methyl, trifluoromethyl, cyano, fluorine, chlorine, bromine, iodine or trifluoromethoxy. Very preferably, moreover, two adjacent radicals R4 represent —(CH2)4—, or —(CH═CH—)2—.
  • R4 with particular preference represents chlorine or bromine,
  • R4 further with particular preference represents iodine or cyano. With particular preference, moreover, two adjacent radicals R4 represent —(CH═CH—)2—.
  • R5 preferably represents C1-C4-alkyl, C3-C6-cycloalkyl, C1-C4-haloalkyl, C1-C6-halocycloalkyl, C2-C6-alkenyl, C2-C4-haloalkenyl, C2-C4-alkynyl, C2-C4-haloalkynyl, C1-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-alkylsulphinyl, C1-C4-alkylsulphonyl, C1-C4-haloalkylthio, C1-C4-haloalkylsulphinyl, C1-C4-haloalkylsulphonyl, halogen, cyano, nitro or C3-C6-trialkylsilyl.
  • R5 more preferably represents C1-C4-alkyl, C3-C6-cycloalkyl, C1-C4-haloalkyl, C1-C6-halocycloalkyl, C2-C6-alkenyl, C2-C4-haloalkenyl, C2-C4-alkynyl, C2-C4-haloalkynyl, C1-C4-alkoxy, C1-C4-haloalkoxy, fluorine, chlorine, bromine, iodine, cyano, nitro or C3-C6-trialkylsilyl.
  • R5 very preferably represents methyl, fluorine, chlorine, bromine or iodine.
  • R5 with particular preference represents methyl or chlorine.
  • R6 preferably represents C1-C6-alkyl or




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  • R6 further preferably represents C3-C6-cycloalkoxy.

  • R6 more preferably represents methyl or





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  • R7 independently at each occurrence preferably represents hydrogen, halogen, cyano, C1-C4, C1-C4-alkoxy, C1-C4-haloalkyl, C1-C4-haloalkoxy, C1-C4-haloalkylsulphonyl or (C1-C4alkyl)C1-C4-alkoxyimino,

  • R7 independently at each occurrence more preferably represents hydrogen, halogen or C1-C4-haloalkyl,

  • R7 very preferably represents fluorine, chlorine or bromine,

  • R7 with particular preference represents chlorine.

  • m preferably represents 1, 2 or 3,

  • m more preferably represents 1 or 2,

  • m very preferably represents 1,

  • X preferably represents N, CH, CF, CCl, CBr or CI,

  • X more preferably represents N, CH, CF, CCl or CBr,

  • X very preferably represents N, CCl or CH.

  • A preferably represents —CH2—, —CH2O—, —CH2OCH2—, —CH2S—, —CH2SCH2—, —CH2N(C1-C6-alkyl)-, —CH2N(C1-C6-alkyl)CH2—, —CH(CN)—, —CH(C1-C6-alkyl)-, —C(di-C1-C6-alkyl)-, —CH2CH2— or —C═NO(C1-C6-alkyl)-,

  • A more preferably represents —CH2—, —CH(CH3), C(CH3)2 or CH2CH2,

  • A further more preferably represents —CH(CN)—,

  • A very preferably represents CH2 or CH(CH3),

  • A with particular preference represents CH2.

  • Q preferably represents an optionally mono- or polysubstituted 5- or 6-membered aromatic heterocyclic ring of series Q-1 to Q-53 or an aromatic 9-membered fused heterobicyclic ring system Q-54 to Q-56, the substituents being selectable independently of one another from C1-C3-alkyl, C1-C3-haloalkyl, C1-C2-alkoxy, halogen, cyano, hydroxyl, nitro or C1-C2-haloalkoxy.

  • Q further preferably represents an optionally mono- or polysubstituted 5- or 6-membered aromatic heterocyclic ring of series Q-1 to Q-53 and Q-58 to Q-59, an aromatic 9-membered fused heterobicyclic ring system Q-54 to Q-56 and also represents a 5-membered heterocyclic ring Q-60 to Q-61, the substituents being selectable independently of one another from C1-C3-alkyl, C1-C3-haloalkyl, C1-C2-alkoxy, halogen, cyano, hydroxyl, nitro or C1-C2-haloalkoxy,
    • or the substituents being selectable independently of one another from phenyl or a 5- or 6-membered heteroaromatic ring, it being possible for phenyl or the ring to be substituted where appropriate one or more times by identical or different C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C3-C6-halocycloalkyl, halogen, CN, NO2, OH, C1-C4-alkoxy or C1-C4-haloalkoxy substituents,

  • Q more preferably represents an optionally mono- or polysubstituted 5- or 6-membered aromatic heterocyclic ring of series Q-36 to Q-40 or an aromatic 9-membered fused heterobicyclic ring system Q-54 to Q-56, the substituents being selectable independently of one another from C1-C3-alkyl, C1-C3-haloalkyl, C1-C2-alkoxy, halogen, cyano, hydroxyl, nitro or C1-C2-haloalkoxy.

  • Q further more preferably represents an optionally mono- or polysubstituted 5- or 6-membered aromatic heterocyclic ring of series Q-36 to Q-40 and Q-58 to Q-59, an aromatic 9-membered fused heterobicyclic ring system Q-54 to Q-56 and also represents a 5-membered heterocyclic ring Q-60 to Q-61, the substituents being selectable independently of one another from C1-C3-alkyl, C1-C3-haloalkyl, C1-C2-alkoxy, halogen, cyano, hydroxyl, nitro or C1-C2-haloalkoxy,
    • or the substituents being selectable independently of one another from phenyl or a 5- or 6-membered heteroaromatic ring, it being possible for phenyl or the ring to be unsubstituted or substituted one or more times by identical or different C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C3-C6-halocycloalkyl, halogen, CN, NO2, C1-C4-alkoxy or C1-C4-haloalkoxy substituents,

  • Q very preferably represents an optionally mono- or polysubstituted aromatic heterocyclic ring of series Q-37, Q-38, Q-39, Q-40, Q-58 and Q-59, and also represents a 5-membered heterocyclic ring Q-60, the substituents being selectable independently of one another from C1-C3-alkyl, C1-C3-haloalkyl, C1-C2-alkoxy, halogen, cyano, hydroxyl, nitro or C1-C2-haloalkoxy,
    • or the substituents being selectable independently of one another from phenyl or a 5- or 6-membered heteroaromatic ring, it being possible for phenyl or the ring to be unsubstituted or substituted one or more times by identical or different C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C3-C6-halocycloalkyl, halogen, CN, NO2, C1-C4-alkoxy or C1-C4-haloalkoxy substituents,

  • Q further very preferably represents an optionally mono- or polysubstituted aromatic heterocyclic ring of series Q-37, Q-38, Q-39, Q-40, Q-58 and Q-59, and also represents a 5-membered heterocyclic ring Q-60, the substituents being selectable independently of one another from C1-C3-alkyl, C1-C3-haloalkyl, halogen, cyano, nitro or C1-C2-haloalkoxy,
    • or the substituents being selectable independently of one another from phenyl or a 5- or 6-membered heteroaromatic ring, it being possible for phenyl or the ring to be unsubstituted or substituted one or more times by identical or different C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C3-C6-halocycloalkyl, halogen, CN, NO2, C1-C4-alkoxy or C1-C4-haloalkoxy substituents,

  • Q with particular preference represents an aromatic heterocyclic ring Q-37, Q-40, Q-58 and Q-59 which is unsubstituted or substituted once, twice or three times on carbon atoms, and also represents a 5-membered heterocyclic ring Q-60, the substituents being selectable independently of one another from chlorine, fluorine, iodine, bromine, cyano, trifluoromethyl and pentafluoroethyl,
    • or the substituents being selectable independently of one another from phenyl, it being possible for the phenyl ring to be unsubstituted or substituted one or more times by identical or different C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C2-C6-haloalkenyl, C2-C6-haloalkynyl, C3-C6-halocycloalkyl, halogen, CN, NO2 or C1-C4-haloalkoxy substituents,

  • Q further with particular preference represents an optionally mono- or polysubstituted aromatic heterocyclic ring of series Q-37, Q-40, Q-58 and Q-59, and also represents a 5-membered heterocyclic ring Q-60, the substituents being selectable independently of one another from chlorine, fluorine, iodine, cyano, trifluoromethyl and pentafluoroethyl,
    • or the substituents being selectable independently of one another from phenyl, it being possible for the phenyl ring to be unsubstituted or substituted one or more times by identical or different chlorine, fluorine, iodine, bromine, cyano, trifluoromethyl and pentafluoroethyl substituents,





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Emphasis is given to the use of compounds of the formula (I-1) according to the invention




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in which R1, R2, R3, R4, R5, R7, A, Q and X have the above-indicated general, preferred, more preferred, very preferred and particularly preferred definitions.


The compounds of the formula (I) or (I-1) may be present in the form of different regioisomers: for example in the form of mixture of compounds with the definition of Q62 and Q63 or in the form of mixtures of Q58 and Q59. The invention therefore also encompasses compounds of the formula (I) or (I-1) where QY is defined as Q62 and Q63, and Q58 and Q59, in different mixing ratios; to be used for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and to methods particularly useful for controlling insects, and/or acarids and/or nematodes and/or increasing crop yield in those crops.


Preference is given to mixing ratios of compounds of the formula (I) in which the QY radical is Q62 or Q58 to compounds of the formula (I) in which the Qy radical is Q63 or Q59 of 60:40 to 99:1, more preferably of 70:30 to 97:3, even more preferably of 80:20 to 99:1. Especially preferred are the following mixing ratios of a compound of the formula (I) where QY is defined as Q62 or Q58 to the compound of the formula (I) where QY is defined as Q63 or Q59: 80:20; 81:19; 82:18; 83:17; 84:16; 85:15, 86:14; 87:13; 88:12; 89:11; 90:10, 91:9; 92:8; 93:7; 94:6, 95:5, 96:4, 97:3, 98:2, 99:1.


More preferred is the use of the compounds (I-1-1) to (I-1-60) according to the invention




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Additionally more preferred is the use of the following mixtures of compounds of the formula (I-1-1) to (I-1-60) according to the invention


I-1-1-/1-1-7, 1-1-2/1-1-8, 1-1-3/1-1-9, I-1-4/1-1-10, I-1-5/1-1-11, I-1-6/1-1-12, I-1-13/I-1-1-19, 1-1-14/1-1-20, I-1-15/I-1-21, I-1-16/I-1-22, I-1-17/I-1-23, I-1-18/I-1-24, 1-1-25/1-1-31, 1-1-26/1-1-32, I-1-27/I-1-33, 1-1-28/1-1-34, I-1-29/I-1-35, I-1-30/I-1-36, 1-1-37/1-1-43, 1-1-38/1-1-44, I-1-39/I-1-45, I-1-40/I-1-46, I-1-41/I-1-47, I-1-42/I-1-48, I-1-49/I-1-55, I-1-50/I-1-56, I-1-51/I-1-57, I-1-52/I-1-58, I-1-53/I-1-59, I-1-54/I-1-60.


In a preferred embodiment the invention also relates to the use of compositions comprising


A) a compound of the general formula (I-1) and


B) at least one further agrochemically active compound


for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and/or increasing crop yield in those crops.


In a preferred embodiment the invention also relates to the use of compositions comprising


A) compound (I-1-1) and


B) at least one further agrochemically active compound


for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and/or increasing crop yield in those crops.


In a preferred embodiment the invention also relates to the use of compositions comprising


A) compound (I-1-2) and


B) at least one further agrochemically active compound


for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and/or increasing crop yield in those crops.


In a preferred embodiment the invention also relates to the use of compositions comprising


A) a mixture of compound (I-1-1)/(I-1-7) and


B) at least one further agrochemically active compound


for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and/or increasing crop yield in those crops.


In a preferred embodiment the invention also relates to the use of compositions comprising


A) a mixture of compound (I-1-2)/(I-1-8) and


B) at least one further agrochemically active compound


for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and/or increasing crop yield in those crops.


In the present context, agrochemically active compounds are to be understood as meaning all substances which are or may be customarily used for treating plants. Fungicides, bactericides, insecticides, acaricides, nematicides, molluscicides, safeners, plant growth regulators and plant nutrients may be mentioned as being preferred.


Mixing Partners


The agrochemically active compound described under B) are the following active ingredients being insecticides which may be mentioned are:


(1) Acetylcholinesterase (AChE) inhibitors, for example


carbamates, e.g. Alanycarb (II-1-1), Aldicarb (II-1-2), Bendiocarb (II-1-3), Benfuracarb (II-1-4), Butocarboxim (II-1-5), Butoxycarboxim (II-1-6), Carbaryl (II-1-7), Carbofuran (II-1-8), Carbosulfan (II-1-9), Ethiofencarb (II-1-10), Fenobucarb (II-1-11), Formetanate (II-1-12), Furathiocarb (II-1-13), Isoprocarb (II-1-14), Methiocarb (II-1-15), Methomyl (II-1-16), Metolcarb (II-1-17), Oxamyl (II-1-18), Pirimicarb (II-1-19), Propoxur (II-1-20), Thiodicarb (II-1-21), Thiofanox (II-1-22), Triazamate (II-1-23), Trimethacarb (II-1-24), XMC (II-1-25), and Xylylcarb (II-1-26); or


organophosphates, e.g. Acephate (II-1-27), Azamethiphos (II-1-28), Azinphos-ethyl (II-1-29), Azinphos-methyl (II-1-30), Cadusafos (II-1-31), Chlorethoxyfos (II-1-32), Chlorfenvinphos (II-1-33), Chlormephos (II-1-34), Chlorpyrifos (II-1-35), Chlorpyrifos-methyl (II-1-36), Coumaphos (II-1-37), Cyanophos (II-1-38), Demeton-S-methyl (II-1-39), Diazinon (II-1-40), Dichlorvos/DDVP (II-1-41), Dicrotophos (II-1-42), Dimethoate (II-1-43), Dimethylvinphos (II-1-44), Disulfoton (II-1-45), EPN (II-1-46), Ethion (II-1-47), Ethoprophos (II-1-48), Famphur (II-1-49), Fenamiphos (II-1-50), Fenitrothion (II-1-51), Fenthion (II-1-52), Fosthiazate (II-1-53), Heptenophos (II-1-54), Imicyafos (II-1-55), Isofenphos (II-1-56), Isopropyl O-(methoxyaminothio-phosphoryl) salicylate (II-1-57), Isoxathion (II-1-58), Malathion (II-1-59), Mecarbam (II-1-60), Methamidophos (II-1-61), Methidathion (II-1-62), Mevinphos (II-1-63), Monocrotophos (II-1-64), Naled (II-1-65), Omethoate (II-1-66), Oxydemeton-methyl (II-1-67), Parathion (II-1-68), Parathion-methyl (II-1-69), Phenthoate (II-1-70), Phorate (II-1-71), Phosalone (II-1-72), Phosmet (II-1-73), Phosphamidon (II-1-74), Phoxim (II-1-75), Pirimiphos-methyl (II-1-76), Profenofos (II-1-77), Propetamphos (II-1-78), Prothiofos (II-1-79), Pyraclofos (II-1-80), Pyridaphenthion (II-1-81), Quinalphos (II-1-82), Sulfotep (II-1-83), Tebupirimfos (II-1-84), Temephos (II-1-85), Terbufos (II-1-86), Tetrachlorvinphos (II-1-87), Thiometon (II-1-88), Triazophos (II-1-89), Trichlorfon (II-1-90), and Vamidothion (II-1-91).


(2) GABA-gated chloride channel antagonists, for example


cyclodiene organochlorines, e.g. Chlordane (II-2-1) and Endosulfan (II-2-2); or


phenylpyrazoles (fiproles), e.g. Ethiprole (II-2-3) and Fipronil (II-2-4).


(3) Sodium channel modulators/voltage-dependent sodium channel blockers, for example


pyrethroids, e.g. Acrinathrin (II-3-1), Allethrin (II-3-2), d-cis-trans Allethrin (II-3-3), d-trans Allethrin (II-3-4), Bifenthrin (II-3-5), Bioallethrin (II-3-6), Bioallethrin S-cyclopentenyl isomer (II-3-7), Bioresmethrin (II-3-8), Cycloprothrin (II-3-9), Cyfluthrin (II-3-10), beta-Cyfluthrin (II-3-11), Cyhalothrin (II-3-12), lambda-Cyhalothrin (II-3-13), gamma-Cyhalothrin (II-3-14), Cypermethrin (II-3-15), alpha-Cypermethrin (II-3-16), beta-Cypermethrin (II-3-17), theta-Cypermethrin (II-3-18), zeta-Cypermethrin (II-3-19), Cyphenothrin [(1R)-trans isomers] (II-3-20), Deltamethrin (II-3-21), Empenthrin [(EZ)-(1R) isomers) (II-3-22), Esfenvalerate (II-3-23), Etofenprox (II-3-24), Fenpropathrin (II-3-25), Fenvalerate (II-3-26), Flucythrinate (II-3-27), Flumethrin (II-3-28), tau-Fluvalinate (II-3-29), Halfenprox (II-3-30), Imiprothrin (II-3-31), Kadethrin (II-3-32), Permethrin (II-3-33), Phenothrin [(1R)-trans isomer) (II-3-34), Prallethrin (II-3-35), Pyrethrine (pyrethrum) (II-3-36), Resmethrin (II-3-37), Silafluofen (II-3-38), Tefluthrin (II-3-39), Tetramethrin (II-3-40), Tetramethrin [(1R) isomers)] (II-3-41), Tralomethrin (II-3-42), and Transfluthrin (II-3-43); or


DDT (II-3-44); or Methoxychlor (II-3-45).


(4) Nicotinic acetylcholine receptor (nAChR) agonists, for example


neonicotinoids, e.g. Acetamiprid (II-4-1), Clothianidin (II-4-2), Dinotefuran (II-4-3), Imidacloprid (II-4-4), Nitenpyram (II-4-5), Thiacloprid (II-4-6), and Thiamethoxam (II-4-7); or


Nicotine (II-4-8).


(5) Nicotinic acetylcholine receptor (nAChR) allosteric activators, for example


spinosyns, e.g. Spinetoram (II-5-1) and Spinosad (II-5-2).


(6) Chloride channel activators, for example


avermectins/milbemycins, e.g. Abamectin (II-6-1), Emamectin benzoate (II-6-2), Lepimectin (II-6-3), and Milbemectin (II-6-4).


(7) Juvenile hormone mimics, for example


juvenile hormone analogues, e.g. Hydroprene (II-7-1), Kinoprene (II-7-2), and Methoprene (II-7-3); or


Fenoxycarb (II-7-4); or Pyriproxyfen (II-7-5).


(8) Miscellaneous non-specific (multi-site) inhibitors, for example


alkyl halides, e.g. Methyl bromide (II-8-1) and other alkyl halides; or


Chloropicrin (II-8-2); or Sulfuryl fluoride (II-8-3); or Borax (II-8-4); or Tartar emetic (II-8-5).


(9) Selective homopteran feeding blockers, e.g. Pymetrozine (II-9-1); or Flonicamid (II-9-2).


(10) Mite growth inhibitors, e.g. Clofentezine (II-10-1), Hexythiazox (II-10-2), and Diflovidazin (II-10-3); or


Etoxazole (II-10-4).


(11) Microbial disruptors of insect midgut membranes, e.g. Bacillus thuringiensis subspecies israelensis (II-11-1), Bacillus sphaericus (II-11-2), Bacillus thuringiensis subspecies aizawai (II-11-3), Bacillus thuringiensis subspecies kurstaki (II-11-4), Bacillus thuringiensis subspecies tenebrionis (II-11-5), and BT crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb, Cry34/35Ab1 (II-11-6).


(12) Inhibitors of mitochondrial ATP synthase, for example Diafenthiuron (II-12-1); or


organotin miticides, e.g. Azocyclotin (II-12-2), Cyhexatin (II-12-3), and Fenbutatin oxide (II-12-4); or


Propargite (II-12-5); or Tetradifon (II-12-6).


(13) Uncouplers of oxidative phoshorylation via disruption of the proton gradient, for example Chlorfenapyr (II-13-1), DNOC (II-13-2), and Sulfluramid (II-13-3).


(14) Nicotinic acetylcholine receptor (nAChR) channel blockers, for example Bensultap (II-14-1), Cartap hydrochloride (II-14-2), Thiocyclam (II-14-3), and Thiosultap-sodium (II-14-4).


(15) Inhibitors of chitin biosynthesis, type 0, for example Bistrifluoron (II-15-1), Chlorfluazuron (II-15-2), Diflubenzuron (II-15-3), Flucycloxuron (II-15-4), Flufenoxuron (II-15-5), Hexaflumuron (II-15-6), Lufenuron (II-15-7), Novaluron (II-15-8), Noviflumuron (II-15-9), Teflubenzuron (II-15-10), and Triflumuron (II-15-11).


(16) Inhibitors of chitin biosynthesis, type 1, for example Buprofezin (II-16-1).


(17) Moulting disruptors, for example Cyromazine (II-17-1).


(18) Ecdysone receptor agonists, for example Chromafenozide (II-18-1), Halofenozide (II-18-2), Methoxyfenozide (II-18-3), and Tebufenozide (II-18-4).


(19) Octopamine receptor agonists, for example Amitraz (II-19-1).


(20) Mitochondrial complex III electron transport inhibitors, for example Hydramethylnon (II-20-1); or Acequinocyl (II-20-2); or Fluacrypyrim (II-20-3).


(21) Mitochondrial complex I electron transport inhibitors, for example


METI acaricides, e.g. Fenazaquin (II-21-1), Fenpyroximate (II-21-2), Pyrimidifen (II-21-3), Pyridaben (II-21-4), Tebufenpyrad (II-21-5), and Tolfenpyrad (II-21-6); or


Rotenone (Derris) (II-21-7).


(22) Voltage-dependent sodium channel blockers, e.g. Indoxacarb (II-22-1); or Metaflumizone (II-22-2).


(23) Inhibitors of acetyl CoA carboxylase, for example


tetronic and tetramic acid derivatives, e.g. Spirodiclofen (II-23-1), Spiromesifen (II-23-2), and Spirotetramat (II-23-3).


(24) Mitochondrial complex IV electron transport inhibitors, for example


phosphines, e.g. Aluminium phosphide (II-24-1), Calcium phosphide (II-24-2), Phosphine (II-24-3), and Zinc phosphide (II-24-4); or


Cyanide (II-24-5).


(25) Mitochondrial complex II electron transport inhibitors, for example Cyenopyrafen (II-25-1).


(28) Ryanodine receptor modulators, for example


diamides, e.g. Chlorantraniliprole (II-28-1) and Flubendiamide (II-28-2).


Further active ingredients with unknown or uncertain mode of action, for example Amidoflumet (II-29-1), Azadirachtin (II-29-2), Benclothiaz (II-29-3), Benzoximate (II-29-4), Bifenazate (II-29-5), Bromopropylate (II-29-6), Chinomethionat (II-29-7), Cryolite (II-29-8), Cyantraniliprole (Cyazypyr) (II-29-9), Cyflumetofen (II-29-10), Dicofol (II-29-11), Diflovidazin (II-29-12), Fluensulfone (II-29-13), Flufenerim (II-29-14), Flufiprole (II-29-15), Fluopyram (II-29-16), Fufenozide (II-29-17), Imidaclothiz (II-29-18), Iprodione (II-29-19), Meperfluthrin (II-29-20), Pyridalyl (II-29-21), Pyrifluquinazon (II-29-22), Tetramethylfluthrin (II-29-23), and iodomethane (II-29-24); furthermore products based on Bacillus firmus (including but not limited to strain CNCM I-1582, such as, for example, VOTiVO™, BioNem) (II-29-25) or one of the following known active compounds: 3-bromo-N-{2-bromo-4-chloro-6-[(1-cyclopropylethyl)carbamoyl]phenyl}-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide (II-29-26) (known from WO2005/077934), 4-{[(6-bromopyridin-3-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one (II-29-27) (known from WO2007/115644), 4-{[(6-fluoropyridin-3-yl)methyl](2,2-difluoroethyl)amino}furan-2(5H)-one (II-29-28) (known from WO2007/115644), 4-{[(2-chloro-1,3-thiazol-5-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one (II-29-29) (known from WO2007/115644), 4-{[(6-chlorpyridin-3-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one (II-29-30) (known from WO2007/115644), Flupyradifurone (II-29-31), 4-{[(6-chlor-5-fluoropyridin-3-yl)methyl](methyl)amino}furan-2(5H)-one (II-29-32) (known from WO2007/115643), 4-{[(5,6-dichloropyridin-3-yl)methyl](2-fluoroethyl)amino}furan-2(5H)-one (II-29-33) (known from WO2007/115646), 4-{[(6-chloro-5-fluoropyridin-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-one (II-29-34) (known from WO2007/115643), 4-{[(6-chloropyridin-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-one (II-29-35) (known from EP-A-0 539 588), 4-{[(6-chlorpyridin-3-yl)methyl](methyl)amino}furan-2(5H)-one (II-29-36) (known from EP-A-0 539 588), {[1-(6-chloropyridin-3-yl)ethyl](methyl)oxido-λ4-sulfanylidene}cyanamide (II-29-37) (known from WO2007/149134) and its diastereomers {[(1R)-1-(6-chloropyridin-3-yl)ethyl](methyl)oxido-λ4-sulfanylidene}cyanamide (A) (II-29-38), and {[(1S)-1-(6-chloropyridin-3-yl)ethyl](methyl)oxido-λ4-sulfanylidene}cyanamide (B) (II-29-39) (also known from WO2007/149134) as well as Sulfoxaflor (II-29-40) and its diastereomers [(R)-methyl(oxido){(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-λ4-sulfanylidene]cyanamide (A1) (II-29-41), and [(S)-methyl(oxido) {(1S)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-λ4-sulfanylidene]cyanamide (A2) (II-29-42), referred to as group of diastereomers A (known from WO2010/074747, WO2010/074751), [(R)-methyl(oxido){(1S)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-λ4-sulfanylidene]cyanamide (B1) (II-29-43), and [(S)-methyl(oxido) {(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethyl}-λ4-sulfanylidene]cyanamide (B2) (II-29-44), referred to as group of diastereomers B (also known from WO2010/074747, WO2010/074751), and 11-(4-chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one (II-29-45) (known from WO2006/089633), 3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one (II-29-46) (known from WO2008/067911), 1-{2-fluoro-4-methyl-5-[(2,2,2-trifluorethyl)sulfinyl]phenyl}-3-(trifluoromethyl)-1H-1,2,4-triazol-5-amine (II-29-47) (known from WO2006/043635), [(3S,4aR,12R,12aS,12bS)-3-[(cyclopropylcarbonyl)oxy]-6,12-dihydroxy-4,12b-dimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-4-yl]methyl cyclopropanecarboxylate (II-29-48) (known from WO2008/066153), 2-cyano-3-(difluoromethoxy)-N,N-dimethylbenzenesulfonamide (II-29-49) (known from WO2006/056433), 2-cyano-3-(difluoromethoxy)-N-methylbenzenesulfonamide (II-29-50) (known from WO2006/100288), 2-cyano-3-(difluoromethoxy)-N-ethylbenzenesulfonamide (II-29-51) (known from WO2005/035486), 4-(difluoromethoxy)-N-ethyl-N-methyl-1,2-benzothiazol-3-amine 1,1-dioxide (II-29-52) (known from WO2007/057407), N-[1-(2,3-dimethylphenyl)-2-(3,5-dimethylphenyl)ethyl]-4,5-dihydro-1,3-thiazol-2-amine (II-29-53) (known from WO2008/104503), {1′-(2E)-3-(4-chlorophenyl)prop-2-en-1-yl]-5-fluorospiro[indole-3,4′-piperidin]-1(2H)-yl}(2-chloropyridin-4-yl)methanone (II-29-54) (known from WO2003/106457), 3-(2,5-dimethylphenyl)-4-hydroxy-8-methoxy-1,8-diazaspiro[4.5]dec-3-en-2-one (II-29-55) (known from WO2009/049851), 3-(2,5-dimethylphenyl)-8-methoxy-2-oxo-1,8-diazaspiro[4.5]dec-3-en-4-yl ethyl carbonate (II-29-56) (known from WO2009/049851), 4-(but-2-yn-1-yloxy)-6-(3,5-dimethylpiperidin-1-yl)-5-fluoropyrimidine (II-29-57) (known from WO2004/099160), (2,2,3,3,4,4,5,5-octafluoropentyl)(3,3,3-trifluoropropyl)malononitrile (II-29-58) (known from WO2005/063094), (2,2,3,3,4,4,5,5-octafluoropentyl)(3,3,4,4,4-pentafluorobutyl)malononitrile (II-29-59) (known from WO2005/063094), 8-[2-(cyclopropylmethoxy)-4-(trifluoromethyl)phenoxy]-3-[6-(trifluoromethyl)pyridazin-3-yl]-3-azabicyclo[3.2.1]octane (II-29-60) (known from WO2007/040280), Flometoquin (II-29-61), PF1364 (CAS-Reg. No. 1204776-60-2) (II-29-62) (known from JP2010/018586), 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile (II-29-63) (known from WO2007/075459), 5-[5-(2-chloropyridin-4-yl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-(1H-1,2,4-triazol-1-yl)benzonitrile (II-29-64) (known from WO2007/075459), 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methyl-N-{2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl}benzamide (II-29-65) (known from WO2005/085216), 4-{[(6-chloropyridin-3-yl)methyl](cyclopropyl)amino}-1,3-oxazol-2(5H)-one (II-29-66), 4-{[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino}-1,3-oxazol-2(5H)-one (II-29-67), 4-{[(6-chloropyridin-3-yl)methyl](ethyl)amino}-1,3-oxazol-2(5H)-one (II-29-68), 4-{[(6-chloropyridin-3-yl)methyl](methyl)amino}-1,3-oxazol-2(5H)-one (II-29-69) (all known from WO2010/005692), NNI-0711 (II-29-70) (known from WO2002/096882), 1-acetyl-N-[4-(1,1,1,3,3,3-hexafluoro-2-methoxypropan-2-yl)-3-isobutylphenyl]-N-isobutyryl-3,5-dimethyl-1H-pyrazole-4-carboxamide (II-29-71) (known from WO2002/096882), methyl 2-[2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)-5-chloro-3-methylbenzoyl]-2-methylhydrazinecarboxylate (II-29-72) (known from WO2005/085216), methyl 2-[2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoyl]-2-ethylhydrazinecarboxylate (II-29-73) (known from WO2005/085216), methyl 2-[2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)-5-cyano-3-methylbenzoyl]-2-methylhydrazinecarboxylate (II-29-74) (known from WO2005/085216), methyl 2-[3,5-dibromo-2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)benzoyl]-1,2-diethylhydrazinecarboxylate (II-29-75) (known from WO2005/085216), methyl 2-[3,5-dibromo-2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)benzoyl]-2-ethylhydrazinecarboxylate (II-29-76) (known from WO2005/085216), (5RS,7RS;5RS,7SR)-1-(6-chloro-3-pyridylmethyl)-1,2,3,5,6,7-hexahydro-7-methyl-8-nitro-5-propoxyimidazo[1,2-a]pyridine (II-29-77) (known from WO2007/101369), 2-{6-[2-(5-fluoropyridin-3-yl)-1,3-thiazol-5-yl]pyridin-2-yl}pyrimidine (II-29-78) (known from WO2010/006713), 2-{6-[2-(pyridin-3-yl)-1,3-thiazol-5-yl]pyridin-2-yl}pyrimidine (II-29-79) (known from WO2010/006713), (1E)-N-[(6-chloropyridin-3-yl)methyl]-N′-cyano-N-(2,2-difluoroethyl)ethanimidamide (II-29-84) (known from WO2008/009360), N-[2-(5-amino-1,3,4-thiadiazol-2-yl)-4-chloro-6-methylphenyl]-3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide (II-29-85) (known from CN102057925), and methyl 2-[3,5-dibromo-2-({[3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl]carbonyl}amino)benzoyl]-2-ethyl-1-methylhydrazinecarboxylate (II-29-86) (known from WO2011/049233);


being fungicides which may be mentioned are:


(1) Inhibitors of the ergosterol biosynthesis, for example (1.1) aldimorph (1704-28-5), (1.2) azaconazole (60207-31-0), (1.3) bitertanol (55179-31-2), (1.4) bromuconazole (116255-48-2), (1.5) cyproconazole (113096-99-4), (1.6) diclobutrazole (75736-33-3), (1.7) difenoconazole (119446-68-3), (1.8) diniconazole (83657-24-3), (1.9) diniconazole-M (83657-18-5), (1.10) dodemorph (1593-77-7), (1.11) dodemorph acetate (31717-87-0), (1.12) epoxiconazole (106325-08-0), (1.13) etaconazole (60207-93-4), (1.14) fenarimol (60168-88-9), (1.15) fenbuconazole (114369-43-6), (1.16) fenhexamid (126833-17-8), (1.17) fenpropidin (67306-00-7), (1.18) fenpropimorph (67306-03-0), (1.19) fluquinconazole (136426-54-5), (1.20) flurprimidol (56425-91-3), (1.21) flusilazole (85509-19-9), (1.22) flutriafol (76674-21-0), (1.23) furconazole (112839-33-5), (1.24) furconazole-cis (112839-32-4), (1.25) hexaconazole (79983-71-4), (1.26) imazalil (60534-80-7), (1.27) imazalil sulfate (58594-72-2), (1.28) imibenconazole (86598-92-7), (1.29) ipconazole (125225-28-7), (1.30) metconazole (125116-23-6), (1.31) myclobutanil (88671-89-0), (1.32) naftifine (65472-88-0), (1.33) nuarimol (63284-71-9), (1.34) oxpoconazole (174212-12-5), (1.35) paclobutrazol (76738-62-0), (1.36) pefurazoate (101903-30-4), (1.37) penconazole (66246-88-6), (1.38) piperalin (3478-94-2), (1.39) prochloraz (67747-09-5), (1.40) propiconazole (60207-90-1), (1.41) prothioconazole (178928-70-6), (1.42) pyributicarb (88678-67-5), (1.43) pyrifenox (88283-41-4), (1.44) quinconazole (103970-75-8), (1.45) simeconazole (149508-90-7), (1.46) spiroxamine (118134-30-8), (1.47) tebuconazole (107534-96-3), (1.48) terbinafine (91161-71-6), (1.49) tetraconazole (112281-77-3), (1.50) triadimefon (43121-43-3), (1.51) triadimenol (89482-17-7), (1.52) tridemorph (81412-43-3), (1.53) triflumizole (68694-11-1), (1.54) triforine (26644-46-2), (1.55) triticonazole (131983-72-7), (1.56) uniconazole (83657-22-1), (1.57) uniconazole-p (83657-17-4), (1.58) viniconazole (77174-66-4), (1.59) voriconazole (137234-62-9), (1.60) 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cycloheptanol (129586-32-9), (1.61) methyl 1-(2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-1H-imidazole-5-carboxylate (110323-95-0), (1.62) N′-{5-(difluoromethyl)-2-methyl-4-[3-(trimethylsilyl)propoxy]phenyl}-N-ethyl-N-methylimidoformamide, (1.63) N-ethyl-N-methyl-N′-{2-methyl-5-(trifluoromethyl)-4-[3-(trimethylsilyl)propoxy]phenyl}imidoformamide and (1.64) O-[1-(4-methoxyphenoxy)-3,3-dimethylbutan-2-yl]1H-imidazole-1-carbothioate (111226-71-2).


(2) inhibitors of the respiratory chain at complex I or II, for example (2.1) bixafen (581809-46-3), (2.2) boscalid (188425-85-6), (2.3) carboxin (5234-68-4), (2.4) diflumetorim (130339-07-0), (2.5) fenfuram (24691-80-3), (2.6) fluopyram (658066-35-4), (2.7) flutolanil (66332-96-5), (2.8) fluxapyroxad (907204-31-3), (2.9) furametpyr (123572-88-3), (2.10) furmecyclox (60568-05-0), (2.11) isopyrazam (mixture of syn-epimeric racemate 1RS,4SR,9RS and anti-epimeric racemate 1RS,4SR,9SR) (881685-58-1), (2.12) isopyrazam (anti-epimeric racemate 1RS,4SR,9SR), (2.13) isopyrazam (anti-epimeric enantiomer 1R,4S,9S), (2.14) isopyrazam (anti-epimeric enantiomer 1S,4R,9R), (2.15) isopyrazam (syn epimeric racemate 1RS,4SR,9RS), (2.16) isopyrazam (syn-epimeric enantiomer 1R,4S,9R), (2.17) isopyrazam (syn-epimeric enantiomer 1S,4R,9S), (2.18) mepronil (55814-41-0), (2.19) oxycarboxin (5259-88-1), (2.20) penflufen (494793-67-8), (2.21) penthiopyrad (183675-82-3), (2.22) sedaxane (874967-67-6), (2.23) thifluzamide (130000-40-7), (2.24) 1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, (2.25) 3-(difluoromethyl)-1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1H-pyrazole-4-carboxamide, (2.26) 3-(difluoromethyl)-N-[4-fluoro-2-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-1-methyl-1H-pyrazole-4-carboxamide, (2.27) N-[1-(2,4-dichlorophenyl)-1-methoxypropan-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide (1092400-95-7) (WO 2008148570), (2.28) 5,8-difluoro-N-[2-(2-fluoro-4-{[4-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)ethyl]quinazolin-4-amine (1210070-84-0) (WO2010025451), (2.29) N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.30) N-[(1S,4R)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide and (2.31) N-[(1R,4S)-9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide.


(3) inhibitors of the respiratory chain at complex III, for example (3.1) ametoctradin (865318-97-4), (3.2) amisulbrom (348635-87-0), (3.3) azoxystrobin (131860-33-8), (3.4) cyazofamid (120116-88-3), (3.5) coumethoxystrobin (850881-30-0), (3.6) coumoxystrobin (850881-70-8), (3.7) dimoxystrobin (141600-52-4), (3.8) enestroburin (238410-11-2) (WO 2004/058723), (3.9) famoxadone (131807-57-3) (WO 2004/058723), (3.10) fenamidone (161326-34-7) (WO 2004/058723), (3.11) fenoxystrobin (918162-02-4), (3.12) fluoxastrobin (361377-29-9) (WO 2004/058723), (3.13) kresoxim-methyl (143390-89-0) (WO 2004/058723), (3.14) metominostrobin (133408-50-1) (WO 2004/058723), (3.15) orysastrobin (189892-69-1) (WO 2004/058723), (3.16) picoxystrobin (117428-22-5) (WO 2004/058723), (3.17) pyraclostrobin (175013-18-0) (WO 2004/058723), (3.18) pyrametostrobin (915410-70-7) (WO 2004/058723), (3.19) pyraoxystrobin (862588-11-2) (WO 2004/058723), (3.20) pyribencarb (799247-52-2) (WO 2004/058723), (3.21) triclopyricarb (902760-40-1), (3.22) trifloxystrobin (141517-21-7) (WO 2004/058723), (3.23) (2E)-2-(2-{[6-(3-chloro-2-methylphenoxy)-5-fluoropyrimidin-4-yl]oxy}phenyl)-2-(methoxyimino)-N-methylethanamide (WO 2004/058723), (3.24) (2E)-2-(methoxyimino)-N-methyl-2-(2-{[({(1E)-1-[3-(trifluoromethyl)phenyl]ethylidene}amino)oxy]methyl}phenyl)ethanamide (WO 2004/058723), (3.25) (2E)-2-(methoxyimino)-N-methyl-2-{2-[(E)-({1-[3-(trifluoromethyl)phenyl]ethoxy}imino)methyl]phenyl}ethanamide (158169-73-4), (3.26) (2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-fluoro-2-phenylethenyl]oxy}phenyl)ethylidene]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylethanamide (326896-28-0), (3.27) (2E)-2-{2-[({[(2E,3E)-4-(2,6-dichlorophenyl)but-3-en-2-ylidene]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylethanamide, (3.28) 2-chloro-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)pyridine-3-carboxamide (119899-14-8), (3.29) 5-methoxy-2-methyl-4-(2-{[({(1E)-1-[3-(trifluoromethyl)phenyl]ethylidene}amino)oxy]methyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one, (3.30) methyl (2E)-2-{2-[{(cyclopropyl[(4-methoxyphenyl)imino]methyl}sulfanyl)methyl]phenyl}-3-methoxyprop-2-enoate (149601-03-6), (3.31) N-(3-ethyl-3,5,5-trimethylcyclohexyl)-3-(formylamino)-2-hydroxybenzamide (226551-21-9), (3.32) 2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide (173662-97-0) and (3.33) (2R)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide (394657-24-0).


(4) Inhibitors of the mitosis and cell division, for example (4.1) benomyl (17804-35-2), (4.2) carbendazim (10605-21-7), (4.3) chlorfenazole (3574-96-7), (4.4) diethofencarb (87130-20-9), (4.5) ethaboxam (162650-77-3), (4.6) fluopicolide (239110-15-7), (4.7) fuberidazole (3878-19-1), (4.8) pencycuron (66063-05-6), (4.9) thiabendazole (148-79-8), (4.10) thiophanate-methyl (23564-05-8), (4.11) thiophanate (23564-06-9), (4.12) zoxamide (156052-68-5), (4.13) 5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine (214706-53-3) and (4.14) 3-chloro-5-(6-chloropyridin-3-yl)-6-methyl-4-(2,4,6-trifluorophenyl)pyridazine (1002756-87-7).


(5) Compounds capable to have a multisite action, like for example (5.1) bordeaux mixture (8011-63-0), (5.2) captafol (2425-06-1), (5.3) captan (133-06-2) (WO 02/12172), (5.4) chlorothalonil (1897-45-6), (5.5) copper hydroxide (20427-59-2), (5.6) copper naphthenate (1338-02-9), (5.7) copper oxide (1317-39-1), (5.8) copper oxychloride (1332-40-7), (5.9) copper(2+) sulfate (7758-98-7), (5.10) dichlofluanid (1085-98-9), (5.11) dithianon (3347-22-6), (5.12) dodine (2439-10-3), (5.13) dodine free base, (5.14) ferbam (14484-64-1), (5.15) fluorofolpet (719-96-0), (5.16) folpet (133-07-3), (5.17) guazatine (108173-90-6), (5.18) guazatine acetate, (5.19) iminoctadine (13516-27-3), (5.20) iminoctadine albesilate (169202-06-6), (5.21) iminoctadine triacetate (57520-17-9), (5.22) mancopper (53988-93-5), (5.23) mancozeb (8018-01-7), (5.24) maneb (12427-38-2), (5.25) metiram (9006-42-2), (5.26) metiram zinc (9006-42-2), (5.27) oxine-copper (10380-28-6), (5.28) propamidine (104-32-5), (5.29) propineb (12071-83-9), (5.30) sulphur and sulphur preparations including calcium polysulphide (7704-34-9), (5.31) thiram (137-26-8), (5.32) tolylfluanid (731-27-1), (5.33) zineb (12122-67-7) and (5.34) ziram (137-30-4).


(6) Compounds capable to induce a host defence, for example (6.1) acibenzolar-S-methyl (135158-54-2), (6.2) isotianil (224049-04-1), (6.3) probenazole (27605-76-1) and (6.4) tiadinil (223580-51-6).


(7) Inhibitors of the amino acid and/or protein biosynthesis, for example (7.1) andoprim (23951-85-1), (7.2) blasticidin-S (2079-00-7), (7.3) cyprodinil (121552-61-2), (7.4) kasugamycin (6980-18-3), (7.5) kasugamycin hydrochloride hydrate (19408-46-9), (7.6) mepanipyrim (110235-47-7), (7.7) pyrimethanil (53112-28-0) and (7.8) 3-(5-fluoro-3,3,4,4-tetramethyl-3,4-dihydroisoquinolin-1-yl)quinoline (861647-32-7) (WO2005070917).


(8) Inhibitors of the ATP production, for example (8.1) fentin acetate (900-95-8), (8.2) fentin chloride (639-58-7), (8.3) fentin hydroxide (76-87-9) and (8.4) silthiofam (175217-20-6).


(9) Inhibitors of the cell wall synthesis, for example (9.1) benthiavalicarb (177406-68-7), (9.2) dimethomorph (110488-70-5), (9.3) flumorph (211867-47-9), (9.4) iprovalicarb (140923-17-7), (9.5) mandipropamid (374726-62-2), (9.6) polyoxins (11113-80-7), (9.7) polyoxorim (22976-86-9), (9.8) validamycin A (37248-47-8) and (9.9) valifenalate (283159-94-4; 283159-90-0).


(10) Inhibitors of the lipid and membrane synthesis, for example (10.1) biphenyl (92-52-4), (10.2) chloroneb (2675-77-6), (10.3) dicloran (99-30-9), (10.4) edifenphos (17109-49-8), (10.5) etridiazole (2593-15-9), (10.6) iodocarb (55406-53-6), (10.7) iprobenfos (26087-47-8), (10.8) isoprothiolane (50512-35-1), (10.9) propamocarb (25606-41-1), (10.10) propamocarb hydrochloride (25606-41-1), (10.11) prothiocarb (19622-08-3), (10.12) pyrazophos (13457-18-6), (10.13) quintozene (82-68-8), (10.14) tecnazene (117-18-0) and (10.15) tolclofos-methyl (57018-04-9).


(11) Inhibitors of the melanine biosynthesis, for example (11.1) carpropamid (104030-54-8), (11.2) diclocymet (139920-32-4), (11.3) fenoxanil (115852-48-7), (11.4) phthalide (27355-22-2), (11.5) pyroquilon (57369-32-1), (11.6) tricyclazole (41814-78-2) and (11.7) 2,2,2-trifluoroethyl {3-methyl-1-[(4-methylbenzoyl)amino]butan-2-yl}carbamate (851524-22-6) (WO2005042474).


(12) Inhibitors of the nucleic acid synthesis, for example (12.1) benalaxyl (71626-11-4), (12.2) benalaxyl-M (kiralaxyl) (98243-83-5), (12.3) bupirimate (41483-43-6), (12.4) clozylacon (67932-85-8), (12.5) dimethirimol (5221-53-4), (12.6) ethirimol (23947-60-6), (12.7) furalaxyl (57646-30-7), (12.8) hymexazol (10004-44-1), (12.9) metalaxyl (57837-19-1), (12.10) metalaxyl-M (mefenoxam) (70630-17-0), (12.11) ofurace (58810-48-3), (12.12) oxadixyl (77732-09-3) and (12.13) oxolinic acid (14698-29-4).


(13) Inhibitors of the signal transduction, for example (13.1) chlozolinate (84332-86-5), (13.2) fenpiclonil (74738-17-3), (13.3) fludioxonil (131341-86-1), (13.4) iprodione (36734-19-7), (13.5) procymidone (32809-16-8), (13.6) quinoxyfen (124495-18-7) and (13.7) vinclozolin (50471-44-8).


(14) Compounds capable to act as an uncoupler, for example (14.1) binapacryl (485-31-4), (14.2) dinocap (131-72-6), (14.3) ferimzone (89269-64-7), (14.4) fluazinam (79622-59-6) and (14.5) meptyldinocap (131-72-6).


(15) Further compounds, for example (15.1) benthiazole (21564-17-0), (15.2) bethoxazin (163269-30-5), (15.3) capsimycin (70694-08-5), (15.4) carvone (99-49-0), (15.5) chinomethionat (2439-01-2), (15.6) pyriofenone (chlazafenone) (688046-61-9), (15.7) cufraneb (11096-18-7), (15.8) cyflufenamid (180409-60-3), (15.9) cymoxanil (57966-95-7), (15.10) cyprosulfamide (221667-31-8), (15.11) dazomet (533-74-4), (15.12) debacarb (62732-91-6), (15.13) dichlorophen (97-23-4), (15.14) diclomezine (62865-36-5), (15.15) difenzoquat (49866-87-7), (15.16) difenzoquat methylsulphate (43222-48-6), (15.17) diphenylamine (122-39-4), (15.18) ecomate, (15.19) fenpyrazamine (473798-59-3), (15.20) flumetover (154025-04-4), (15.21) fluoroimide (41205-21-4), (15.22) flusulfamide (106917-52-6), (15.23) flutianil (304900-25-2), (15.24) fosetyl-aluminium (39148-24-8), (15.25) fosetyl-calcium, (15.26) fosetyl-sodium (39148-16-8), (15.27) hexachlorobenzene (118-74-1), (15.28) irumamycin (81604-73-1), (15.29) methasulfocarb (66952-49-6), (15.30) methyl isothiocyanate (556-61-6), (15.31) metrafenone (220899-03-6), (15.32) mildiomycin (67527-71-3), (15.33) natamycin (7681-93-8), (15.34) nickel dimethyldithiocarbamate (15521-65-0), (15.35) nitrothal-isopropyl (10552-74-6), (15.36) octhilinone (26530-20-1), (15.37) oxamocarb (917242-12-7), (15.38) oxyfenthiin (34407-87-9), (15.39) pentachlorophenol and salts (87-86-5), (15.40) phenothrin, (15.41) phosphorous acid and its salts (13598-36-2), (15.42) propamocarb-fosetylate, (15.43) propanosine-sodium (88498-02-6), (15.44) proquinazid (189278-12-4), (15.45) pyrimorph (868390-90-3), (15.45e) (2E)-3-(4-tert-butylphenyl)-3-(2-chloropyridin-4-yl)-1-(morpholin-4-yl)prop-2-en-1-one (1231776-28-5), (15.45z) (2Z)-3-(4-tert-butylphenyl)-3-(2-chloropyridin-4-yl)-1-(morpholin-4-yl)prop-2-en-1-one (1231776-29-6), (15.46) pyrrolnitrine (1018-71-9) (EP-A 1 559 320), (15.47) tebufloquin (376645-78-2), (15.48) tecloftalam (76280-91-6), (15.49) tolnifanide (304911-98-6), (15.50) triazoxide (72459-58-6), (15.51) trichlamide (70193-21-4), (15.52) zarilamid (84527-51-5), (15.53) (3S,6S,7R,8R)-8-benzyl-3-[({3-[(isobutyryloxy)methoxy]-4-methoxypyridin-2-yl}carbonyl)amino]-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl 2-methylpropanoate (517875-34-2) (WO2003035617), (15.54) 1-(4-{4-[(5R)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (1003319-79-6) (WO 2008013622), (15.55) 1-(4-{4-[(5S)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (1003319-80-9) (WO 2008013622), (15.56) 1-(4-{4-[5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone (1003318-67-9) (WO 2008013622), (15.57) 1-(4-methoxyphenoxy)-3,3-dimethylbutan-2-yl 1H-imidazole-1-carboxylate (111227-17-9), (15.58) 2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine (13108-52-6), (15.59) 2,3-dibutyl-6-chlorothieno[2,3-d]pyrimidin-4(3H)-one (221451-58-7), (15.60) 2,6-dimethyl-1H,5H-[1,4]dithiino[2,3-c:5,6-c′]dipyrrole-1,3,5,7(2H,6H)-tetrone, (15.61) 2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[(5R)-5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone (1003316-53-7) (WO 2008013622), (15.62) 2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[(5S)-5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone (1003316-54-8) (WO 2008013622), (15.63) 2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-{4-[4-(5-phenyl-4,5-dihydro-1,2-oxazol-3-yl)-1,3-thiazol-2-yl]piperidin-1-yl}ethanone (1003316-51-5) (WO 2008013622), (15.64) 2-butoxy-6-iodo-3-propyl-4H-chromen-4-one, (15.65) 2-chloro-5-[2-chloro-1-(2,6-difluoro-4-methoxyphenyl)-4-methyl-1H-imidazol-5-yl]pyridine, (15.66) 2-phenylphenol and salts (90-43-7), (15.67) 3-(4,4,5-trifluoro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)quinoline (861647-85-0) (WO2005070917), (15.68) 3,4,5-trichloropyridine-2,6-dicarbonitrile (17824-85-0), (15.69) 3-[5-(4-chlorophenyl)-2,3-dimethyl-1,2-oxazolidin-3-yl]pyridine, (15.70) 3-chloro-5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methylpyridazine, (15.71) 4-(4-chlorophenyl)-5-(2,6-difluorophenyl)-3,6-dimethylpyridazine, (15.72) 5-amino-1,3,4-thiadiazole-2-thiol, (15.73) 5-chloro-N′-phenyl-N′-(prop-2-yn-1-yl)thiophene-2-sulfonohydrazide (134-31-6), (15.74) 5-fluoro-2-[(4-fluorobenzyl)oxy]pyrimidin-4-amine (1174376-11-4) (WO2009094442), (15.75) 5-fluoro-2-[(4-methylbenzyl)oxy]pyrimidin-4-amine (1174376-25-0) (WO2009094442), (15.76) 5-methyl-6-octyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, (15.77) ethyl (2Z)-3-amino-2-cyano-3-phenylprop-2-enoate, (15.78) N′-(4-{[3-(4-chlorobenzyl)-1,2,4-thiadiazol-5-yl]oxy}-2,5-dimethylphenyl)-N-ethyl-N-methylimidoformamide, (15.79) N-(4-chlorobenzyl)-3-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide, (15.80) N-[(4-chlorophenyl)(cyano)methyl]-3-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide, (15.81) N-[(5-bromo-3-chloropyridin-2-yl)methyl]-2,4-dichloropyridine-3-carboxamide, (15.82) N-[1-(5-bromo-3-chloropyridin-2-yl)ethyl]-2,4-dichloropyridine-3-carboxamide, (15.83) N-[1-(5-bromo-3-chloropyridin-2-yl)ethyl]-2-fluoro-4-iodopyridine-3-carboxamide, (15.84) N-{(E)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]methyl}-2-phenylacetamide (221201-92-9), (15.85) N-{(Z)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]methyl}-2-phenylacetamide (221201-92-9), (15.86) N′-{4-[(3-tert-butyl-4-cyano-1,2-thiazol-5-yl)oxy]-2-chloro-5-methylphenyl}-N-ethyl-N- methylimidoformamide, (15.87) N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,3-thiazole-4-carboxamide (922514-49-6) (WO 2007014290), (15.88) N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1,3-thiazole-4-carboxamide (922514-07-6) (WO 2007014290), (15.89) N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-N-[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]-1,3-thiazole-4-carboxamide (922514-48-5) (WO 2007014290), (15.90) pentyl {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylidene]amino}oxy)methyl]pyridin-2-yl}carbamate, (15.91) phenazine-1-carboxylic acid, (15.92) quinolin-8-ol (134-31-6), (15.93) quinolin-8-ol sulfate (2:1) (134-31-6) and (15.94) tert-butyl {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate.


(16) Further compounds, for example (16.1) 1-methyl-3-(trifluoromethyl)-N-[2′-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide, (16.2) N-(4′-chlorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (16.3) N-(2′,4′-dichlorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (16.4) 3-(difluoromethyl)-1-methyl-N-[4′-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide, (16.5) N-(2′,5′-difluorobiphenyl-2-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, (16.6) 3-(difluoromethyl)-1-methyl-N-[4′-(prop-1-yn-1-yl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.7) 5-fluoro-1,3-dimethyl-N-[4′-(prop-1-yn-1-yl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.8) 2-chloro-N-[4′-(prop-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (16.9) 3-(difluoromethyl)-N-[4′-(3,3-dimethylbut-1-yn-1-yl)biphenyl-2-yl]-1-methyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.10) N-[4′-(3,3-dimethylbut-1-yn-1-yl)biphenyl-2-yl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.11) 3-(difluoromethyl)-N-(4′-ethynylbiphenyl-2-yl)-1-methyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.12) N-(4′-ethynylbiphenyl-2-yl)-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.13) 2-chloro-N-(4′-ethynylbiphenyl-2-yl)pyridine-3-carboxamide (known from WO 2004/058723), (16.14) 2-chloro-N-[4′-(3,3-dimethylbut-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (16.15) 4-(difluoromethyl)-2-methyl-N-[4′-(trifluoromethyl)biphenyl-2-yl]-1,3-thiazole-5-carboxamide (known from WO 2004/058723), (16.16) 5-fluoro-N-[4′-(3-hydroxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.17) 2-chloro-N-[4′-(3-hydroxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (16.18) 3-(difluoromethyl)-N-[4′-(3-methoxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]-1-methyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.19) 5-fluoro-N-[4′-(3-methoxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (16.20) 2-chloro-N-[4′-(3-methoxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (16.21) (5-bromo-2-methoxy-4-methylpyridin-3-yl)(2,3,4-trimethoxy-6-methylphenyl)methanone (known from EP-A 1 559 320), (16.22) N-[2-(4-{[3-(4-chlorophenyl)prop-2-yn-1-yl]oxy}-3-methoxyphenyl)ethyl]-N2-(methylsulfonyl)valinamide (220706-93-4), (16.23) 4-oxo-4-[(2-phenylethyl)amino]butanoic acid and (16.24) but-3-yn-1-yl {6-[{([(Z)-(1-methyl-1H-tetrazol-5-yl)(phenyl)methylene]amino}oxy)methyl]pyridin-2-yl}carbamate, N-[9-(dichloromethylene)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide and 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid [2-(2,4-dichlorophenyl)-2-methoxy-1-methyl-ethyl]-amide.


Wherein all named mixing partners of the classes (1) to (16) can, if their functional groups enable this, optionally form salts with suitable bases or acids;


Being bactericides which may be mentioned are:


bronopol, dichlorophen, nitrapyrin, nickel dimethyldithiocarbamate, kasugamycin, octhilinone, furancarboxylic acid, oxytetracycline, probenazole, streptomycin, tecloftalam, copper sulphate and other copper preparations.


being safeners which may be mentioned are:


(1) Heterocyclic carboxylic acid derivates, for example dichlorophenylpyrazolin-3-carboxylic acid derivatives, e.g. 1-(2,4-dichlorophenyl)-5-(ethoxycarbonyl)-5-methyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid, diethyl 1-(2,4-dichlorophenyl)-4,5-dihydro-5-methyl-1H-pyrazole-3,5-dicarboxylate (“mefenpyr-diethyl”), and similar compounds known from WO 91/07874; for example dichlorophenylpyrazolecarboxylic acid derivatives, e.g. ethyl 1-(2,4-dichlorophenyl)-5-methyl-1H-pyrazole-3-carboxylate, ethyl 1-(2,4-dichlorophenyl)-5-isopropyl-1H-pyrazole-3-carboxylate, ethyl 5-tert-butyl-1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylate and similar compounds known from EP-A 0 333 131 and EP-A 0 269 806; for example 1,5-diphenylpyrazole-3-carboxylic acid derivatives, e.g. ethyl 1-(2,4-dichlorophenyl)-5-phenyl-1H-pyrazole-3-carboxylate, methyl 1-(2-chlorophenyl)-5-phenyl-1H-pyrazole-3-carboxylate, and similar compounds known from EP-A 0 268 554; for example triazolecarboxylic acid derivatives, e.g. fenchlorazole, fenchlorazole-ethyl, and similar compounds known from EP-A 0 174 562 and EP-A 0 346 620; for example 2-isoxazoline-3-carboxylic acid derivatives, e.g. ethyl 5-(2,4-dichlorobenzyl)-4,5-dihydro-1,2-oxazole-3-carboxylate, ethyl 5-phenyl-4,5-dihydro-1,2-oxazole-3-carboxylate and similar compounds known from WO 91/08202, or 5,5-diphenyl-4,5-dihydro-1,2-oxazole-3-carboxylic acid, ethyl 5,5-diphenyl-4,5-dihydro-1,2-oxazole-3-carboxylate (“isoxadifen-ethyl”), propyl 5,5-diphenyl-4,5-dihydro-1,2-oxazole-3-carboxylate, ethyl 5-(4-fluorophenyl)-5-phenyl-4,5-dihydro-1,2-oxazole-3-carboxylate known from WO 95/07897.


(2) Derivatives of 8-quinolinol, for example derivatives of (quinolin-8-yloxy)acetic acid, e.g. heptan-2-yl[(5-chloroquinolin-8-yl)oxy]acetate (“cloquintocet-mexyl”), 4-methylpentan-2-yl[(5-chloroquinolin-8-yl)-oxy]acetate,4-(allyloxy)butyl [(5-chloroquinolin-8-yl)oxy]acetate, 1-(allyloxy)propan-2-yl[(5-chloroquinolin-8-yl)oxy]acetate, ethyl [(5-chloroquinolin-8-yl)oxy]acetate, methyl [(5-chloroquinolin-8-yl)oxy]acetate, allyl [(5-chloroquinolin-8-yl)oxy]acetate, 2-{[propylideneamino]oxy}ethyl [(5-chloroquinolin-8-yl)oxy]acetate, 2-oxopropyl [(5-chloroquinolin-8-yl)oxy]acetate, and similar compounds known from EP-A 0 086 750, EP-A 0 094 349, EP-A 0 191 736 or EP-A 0 492 366, as well as [(5-chloroquinolin-8-yl)oxy]acetic acid, its hydrates and salts, e.g. the lithium, sodium, potassium, calcium, magnesium, aluminum, iron, ammonium, quartanary ammonium, sulfonium or phosphonium salts as known from WO 02/34048; for example derivatives of [(5-chloroquinolin-8-yl)oxy]malonic acid, e.g diethyl [(5-chloroquinolin-8-yl)oxy]malonate, diallyl [(5-chloroquinolin-8-yl)oxy]malonate, ethyl methyl [(5-chloroquinolin-8-yl)oxy]malonate, and similar compounds known from EP-A 0 582 198.


(3) Dichloroacetamides, which are often used as pre-emergence safeners (soil active safeners), e.g. “dichlormid” (N,N-diallyl-2,2-dichloroacetamide), “R-29148” (3dichloroacetyl-2,2,5-trimethyl-1,3-oxazolidine) and “R-28725” (3-dichloroacetyl-2,2,-dimethyl-1,3-oxazolidine) both of the company Stauffer, “benoxacor” (4-dichloroacetyl-3,4-dihydro-3-methyl-2H-1,4-benzoxazine), “PPG-1292” (N-allyl-N-[(1,3-dioxolan-2-yl)-methyl]-dichloroacetamide) of PPG Industries, “DKA-24” (N-allyl-N-[(allylaminocarbonyl)methyl]-dichloroacetamide) of Sagro-Chem, “AD-67” or “MON 4660” (3-dichloroacetyl-1-oxa-3-aza-spiro[4,5]decane) of Nitrokemia and Monsanto, “TI-35” (1-dichloroacetyl-azepane) of TRI-Chemical RT, “diclonon” (dicyclonon) or “BAS145138” or “LAB145138” (3-dichloroacetyl-2,5,5-trimethyl-1,3-diazabicyclo[4.3.0]nonane) of BASF, “Furilazol” or “MON 13900” [(RS)-3-dichloroacetyl-5-(2-furyl)-2,2-dimethyloxazolidine], as well as there (R)-isomer.


(4) Acylsulfonamides, for example N-acylsulfonamide of the formula (II)




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or its salts (known from WO 97/45016), wherein

  • R1 represents (C1-C6)alkyl, which is unsubstituted or mono- to trisubstituted by substituents selected from the group consisting of halogen, (C1-C4)alkoxy, (C1-C6)haloalkoxy and (C1-C4)alkylthio;
  • R2 represents halogen, (C1-C4)alkyl, (C1-C4)alkoxy, CF3;
  • m is 1 or 2;


or for example 4-(benzoylsulfamoyl)benzamides of the formula (III)




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or its salts (known from WO 99/16744), wherein

  • R3, R4 independently of one another represent hydrogen, (C1-C6)alkyl, (C3-C6)alkenyl, (C3-C6)alkynyl, (C3-C6)cycloalkyl,
  • R5 represents halogen, (C1-C4)alkyl, (C1-C4)haloalkyl or (C1-C4)alkoxy
  • n is 1 or 2,


in particular compounds of formula (III), wherein


R3=cyclopropyl, R4=hydrogen and R5n=2-OMe, (“cyprosulfamide”),


R3=cyclopropyl, R4=hydrogen and R5n=5-Cl-2-OMe,


R3=ethyl, R4=hydrogen and R5n=2-OMe,


R3=isopropyl, R4=hydrogen and R5n=5-Cl-2-OMe,


R3=isopropyl, R4=hydrogen and R5n=2-OMe.


or for example benzoylsulfamoylphenylureas of the formula (IV)




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(known from EP-A 0 365 484), wherein

  • R6, R7 independently of one another represent hydrogen, (C1-C8)alkyl, (C3-C6)alkenyl, (C3-C6)alkynyl,
  • R8 represents halogen, (C1-C4)alkyl, (C1-C4)alkoxy, CF3
  • r is 1 or 2;


in particular

  • 1-[4-(N-2-methoxybenzoylsulfamoyl)phenyl]-3-methyl urea,
  • 1-[4-(N-2-methoxybenzoylsulfamoyl)phenyl]-3,3-dimethyl urea,
  • 1-[4-(N-4,5-dimethylbenzoylsulfamoyl)phenyl]-3-methyl urea.


(5) Hydroxyaromatic compounds and aromatic-aliphatic carboxylic acid derivatives, e.g. ethyl 3,4,5-triacetoxybenzoate, 4-hydroxy-3,5-dimethoxybenzoic acid, 3,5-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, 4-fluoro-2-hydroxybenzoic acid, 2-hydroxycinnamic acid, 2,4-dichlorocinnamic acid (cf. WO 2004/084631, WO 2005/015994, WO 2005/016001).


(6) 1,2-Dihydrochinoxalin-2-ones, e.g. 1-methyl-3-(2-thienyl)-1,2-dihydrochinoxalin-2-one, 1-methyl-3-(2-thienyl)-1,2-dihydrochinoxalin-2-thione, 1-(2-aminoethyl)-3-(2-thienyl)-1,2-dihydrochinoxalin-2-one hydrochlorid, 1-(2-methyl sulfonylaminoethyl)-3-(2-thienyl)-1,2-dihydrochinoxalin-2-one (cf. WO 2005/112630).


(7) Diphenylmethoxyacetic acid derivatives, e.g. methyl (diphenylmethoxy)acetate (CAS-Reg. No. 41858-19-9), ethyl (diphenylmethoxy)acetate or (diphenylmethoxy)acetic acid (cf. WO 98/38856).


(8) Compounds of formula (V)




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or its salts (known from WO 98/27049), wherein

  • R9 represents halogen, (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C4)haloalkoxy,
  • R10 represents hydrogen or (C1-C4)alkyl,
  • R10 represents hydrogen, in each case unsubstituted or mono- to trisubstituted (C1-C8)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, or aryl, where the substituents are selected from the group consisting of halogen and (C1-C8)alkoxy,
  • s is 0, 1 or 2.


(9) 3-(5-Tetrazolylcarbonyl)-2-chinolones, e.g. 1,2-dihydro-4-hydroxy-1-ethyl-3-(5-tetrazolylcarbonyl)-2-chinolone (CAS-Reg. No. 219479-18-2), 1,2-dihydro-4-hydroxy-1-methyl-3-(5-tetrazolylcarbonyl)-2-chinolone (CAS-Reg. No. 95855-00-8) (cf. WO 99/00020).


(10) Compounds of the formulae (VI-a) and (VI-b)




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(known from WO 2007/023719 and WO 2007/023764), wherein

  • R12 represents halogen, (C1-C4)alkyl, methoxy, nitro, cyano, CF3, OCF3,
  • Y, Z independently represent O or S,
  • t is 0, 1, 2, 3 or 4,
  • R13 represents (C1-C16)alkyl, (C2-C6)alkenyl, aryl, benzyl, halogenobenzyl,
  • R14 represents hydrogen or (C1-C6)alkyl.


(11) Oxyimino compounds, known as seed treatment agents, e.g. “oxabetrinil” [(Z)-1,3-dioxolan-2-ylmethoxyimino(phenyl)acetonitril], “fluxofenim” [1-(4-chlorophenyl)-2,2,2-trifluoro-1-ethanone-O-(1,3-dioxolan-2-ylmethyl)-oxime], and “cyometrinil” or “CGA-43089” [(Z)-cyanomethoxy-imino(phenyl)acetonitril], all known as seed treatment safener for sorghum against damage by metolachlor.


(12) Isothiochromanones, e.g. methyl [(3-oxo-1H-2-benzothiopyran-4(3H)-ylidene)methoxy]acetate (CAS-Reg. No. 205121-04-6) and similar compounds known from WO 98/13361.


(13) Compounds from the group consisting of “naphthalic anhydrid” (1,8-naphthalinedicarboxylic acid anhydride), which is known as seed treatment safener for corn (maize) against damage by thiocarbamate herbicides, “fenclorim” (4,6-dichloro-2-phenylpyrimidine), which is known as seed treatment safener in sown rice against damage by pretilachlor, “flurazole” (benzyl-2-chloro-4-trifluoromethyl-1,3-thiazol-5-carboxylate), which is known as seed treatment safener for sorghum against damage by alachlor and metolachlor, “CL 304415” (CAS-Reg. No. 31541-57-8), (4-carboxy-3,4-dihydro-2H-1-benzopyran-4-acetic acid) of American Cyanamid, which is known as safener for corn (maize) against damage by imidazolinones, “MG 191” (CAS-Reg. No. 96420-72-3) (2-dichloromethyl-2-methyl-1,3-dioxolane) of Nitrokemia, known as safener for corn (maize), “MG-838” (CAS-Reg. No. 133993-74-5), (2-propenyl 1-oxa-4-azaspiro[4.5]decane-4-carbodithioate) of Nitrokemia, “Disulfoton” (O,O-diethyl-S-2-ethylthioethyl phosphorodithioate), “dietholate” (O,O-diethyl-O-phenylphosphorothioate), “mephenate” (4-chlorophenyl-methylcarbamate).


(14) Compounds, which besides herbicidal activity als exhibit Safener activity in crops like rice, e.g. “Dimepiperate” or “MY-93” (S-1-methyl-1-phenylethyl-piperidin-1-carbothioate), which is known as safener for rice against damage by molinate, “daimuron” or “SK 23” [1-(1-methyl-1-phenylethyl)-3-p-tolyl-urea], which is known as safener for rice against damage by imazosulfuron, “cumyluron”=“JC-940” [3-(2-chlorophenylmethyl)-1-(1-methyl-1-phenyl-ethyl)urea] (cf. JP-A 60-087254), which is known as safener for rice against damage by some herbicides, “methoxyphenon” or “NK 049” (3,3′-dimethyl-4-methoxy-benzophenone), which is known as safener for rice against damage by some herbicides, “CSB” [1-bromo-4-(chloromethylsulfonyl)benzene] of Kumiai (CAS-Reg. No. 54091-06-4), which is known as safener for rice against damage by some herbicides.


(15) Compounds, which are mainly used as herbicides, but which exhibit also safener activity on some crops, e.g. (2,4-dichlorophenoxy)acetic acid (2,4-D), (4-chlorophenoxy)acetic acid, (R,S)-2-(4-chlor-o-tolyloxy)propionic acid (mecoprop), 4-(2,4-dichlorophenoxy)butyric acid (2,4-DB), (4-chloro-o-tolyloxy)acetic acid (MCPA), 4-(4-chloro-o-tolyloxy)butyric acid, 4-(4-chlorophenoxy)butyric acid, 3,6-dichloro-2-methoxybenzoic acid (dicamba), 1-(ethoxycarbonyl)ethyl-3,6-dichloro-2-methoxybenzoate (lactidichlor-ethyl).


being plant growth regulators which may be mentioned are chlorocholine chloride and ethephon.


Examples of plant nutrients which may be mentioned are customary inorganic or organic fertilizers for supplying plants with macro- and/or micronutrients.


The active ingredients specified herein by their “common name” are known and described, for example, in the Pesticide Manual (“The Pesticide Manual”, 14th Ed., British Crop Protection Council 2006) or can be searched in the internet (e.g. http://www.alanwood.net/pesticides).


In a preferred embodiment the present invention relates to the use of a composition comprising A) a compound of the general formula (I) and B) one or more of the following insecticides: Acrinathrin, Alpha-Cypermethrin, Betacyfluthrin, Cyhalothrin, Cypermethrin, Deltamethrin, Lambda-Cyhalothrin, Gamma-Cyhalothrin, Transfluthrin, Cyfluthrin, Bifenthrin, Tefluthrin, Imidacloprid, Acetamiprid, Thiamethoxam, Thiacloprid, Dinotefuran, Clothianidin, Lufenuron, Triflumuron, Novaluron, Flufenoxuron, Buprofezin, Methoxyfenozide, Tebufenozide, Fipronil, Ethiprole, Flubendiamide, Chlorantraniliprole (Rynaxypyr), Cyazypyr, Emamectin, Emamectin benzoate, Abamectin, Milbemectin, Tebufenpyrad, Fenpyroximat, Diafenthiuron, Spinosad, Flonicamid, Chlorfenapyr, Metaflumizone, Indoxacarb, Chlorpyrifos, Spirodiclofen, Spiromesifen, Spirotetramat, Pyridalyl, Spinetoram, Acephate, Triazophos, Profenofos, Fenamiphos, 4-{[(6-Chlorpyrid-3-yl)methyl](2,2-difluorethyl)amino}furan-2(5H)-on, Cadusaphos, Carbaryl, Carbofuran, Ethoprophos, Thiodicarb, Aldicarb, Metamidophos, Methiocarb, Sulfoxaflor, Methomyl, Imicyafos, Fluensulfone, 11-(4-Chlor-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-on, 2-{6-[2-(5-Fluorpyridin-3-yl)-1,3-thiazol-5-yl]pyridin-2-yl}pyrimidin.


In a preferred embodiment the present invention relates to the use of a composition comprising A) a compound of the general formula (I) and B) one or more of the following fungicides: Bitertanol, Bixafen, Carpropamid, Fenamidone, Fluopicolide, Fluopyram, Fluoxastrobin, Fluquinconazole, Isotianil, Metaminostrobin, Pencycuron, Penflufen, Prochloraz, Propamocarb, Propineb, Prothioconazole, Spiroxamine, Tebuconazole, Triadimenol, Triazoxide, TrifloxystrobinAmetoctradin, Azoxystrobin, Benthiavalicarb, Boscalid, Carbendazim, Carboxin, Chlorothalonil, Cymoxanil, Cyproconazole, Cyprodinil, Cyzofamid, Difenoconazole, Dimoxystrobin, Epoxiconazole, Fenpropidin, Ferimzone, Fluazinam, Fludioxonil, Flutolanil, Flutriafol, Fluxapyroxad, Gentamycin, Hymexazol, Imazalil, Ipconazole, Isoprothiolane, Isopyrazam, Kasugamycin, Mancozeb, Mandipropamid, Maneb, Mefenoxam, Metalaxyl, Metconazole, Metrafenone, Orysastrobin, Penthiopyrad, Picoxystrobin, Probenazole, Propiconazole, Proquinazid, Pyraclostrobin, Pyrimethanil, Pyroquilon, Quinoxyfen, Sedaxane, Tetraconazole, Thiophanate-methyl, Thiram, Tolclofos-methyl, Tricyclazole, Triticonazole, Validamycin.


Agricultural Pests


The agricultural pests and pathogens to be controlled when a compound of formula (I) or compositions comprising a compound of the formula (I) are used or employed according to the invention are given hereafter:

    • pests from the phylum Arthropoda, especially from the class Arachnida, for example, Acarus spp., Aceria sheldoni, Aculops spp., Aculus spp., Amblyomma spp., Amphitetranychus viennensis, Argas spp., Boophilus spp., Brevipalpus spp., Bryobia graminum, Bryobia praetiosa, Centruroides spp., Chorioptes spp., Dermanyssus gallinae, Dermatophagoides pteronyssinus, Dermatophagoides farinae, Dermacentor spp., Eotetranychus spp., Epitrimerus pyri, Eutetranychus spp., Eriophyes spp., Glycyphagus domesticus, Halotydeus destructor, Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus spp., Loxosceles spp., Metatetranychus spp., Neutrombicula autumnalis, Nuphersa spp., Oligonychus spp., Ornithodorus spp., Ornithonyssus spp., Panonychus spp., Phyllocoptruta oleivora, Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp., Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus, Steneotarsonemus spp., Steneotarsonemus spinki, Tarsonemus spp., Tetranychus spp., Trombicula alfreddugesi, Vaejovis spp., Vasates lycopersici;


from the class Chilopoda, for example, Geophilus spp., Scutigera spp.;


from the order or the class Collembola, for example, Onychiurus armatus;


from the class Diplopoda, for example, Blaniulus guttulatus;


from the class Insecta, e.g. from the order Blattodea, for example, Blattella asahinai, Blattella germanica, Blatta orientalis, Leucophaea maderae, Panchlora spp., Parcoblatta spp., Periplaneta spp., Supella longipalpa;


from the order Coleoptera, for example, Acalymma vittatum, Acanthoscelides obtectus, Adoretus spp., Agelastica alni, Agriotes spp., Alphitobius diaperinus, Amphimallon solstitialis, Anobium punctatum, Anoplophora spp., Anthonomus spp., Anthrenus spp., Apion spp., Apogonia spp., Atomaria spp., Attagenus spp., Bruchidius obtectus, Bruchus spp., Cassida spp., Cerotoma trifurcata, Ceutorrhynchus spp., Chaetocnema spp., Cleonus mendicus, Conoderus spp., Cosmopolites spp., Costelytra zealandica, Ctenicera spp., Curculio spp., Cryptolestes ferrugineus, Cryptorhynchus lapathi, Cylindrocopturus spp., Dermestes spp., Diabrotica spp., Dichocrocis spp., Dicladispa armigera, Diloboderus spp., Epilachna spp., Epitrix spp., Faustinus spp., Gibbium psylloides, Gnathocerus cornutus, Hellula undalis, Heteronychus arator, Heteronyx spp., Hylamorpha elegans, Hylotrupes bajulus, Hypera postica, Hypomeces squamosus, Hypothenemus spp., Lachnosterna consanguinea, Lasioderma serricorne, Latheticus oryzae, Lathridius spp., Lema spp., Leptinotarsa decemlineata, Leucoptera spp., Lissorhoptrus oryzophilus, Lixus spp., Luperodes spp., Lyctus spp., Megascelis spp., Melanotus spp., Meligethes aeneus, Melolontha spp., Migdolus spp., Monochamus spp., Naupactus xanthographus, Necrobia spp., Niptus hololeucus, Oryctes rhinoceros, Oryzaephilus surinamensis, Oryzaphagus oryzae, Otiorrhynchus spp., Oxycetonia jucunda, Phaedon cochleariae, Phyllophaga spp., Phyllophaga helleri, Phyllotreta spp., Popillia japonica, Premnotrypes spp., Prostephanus truncatus, Psylliodes spp., Ptinus spp., Rhizobius ventralis, Rhizopertha dominica, Sitophilus spp., Sitophilus oryzae, Sphenophorus spp., Stegobium paniceum, Sternechus spp., Symphyletes spp., Tanymecus spp., Tenebrio molitor, Tenebrioides mauretanicus, Tribolium spp., Trogoderma spp., Tychius spp., Xylotrechus spp., Zabrus spp.;


from the order Diptera, for example, Aedes spp., Agromyza spp., Anastrepha spp., Anopheles spp., Asphondylia spp., Bactrocera spp., Bibio hortulanus, Calliphora erythrocephala, Calliphora vicina, Ceratitis capitata, Chironomus spp., Chrysomyia spp., Chrysops spp., Chrysozona pluvialis, Cochliomyia spp., Contarinia spp., Cordylobia anthropophaga, Cricotopus sylvestris, Culex spp., Culicoides spp., Culiseta spp., Cuterebra spp., Dacus oleae, Dasyneura spp., Delia spp., Dermatobia hominis, Drosophila spp., Echinocnemus spp., Fannia spp., Gasterophilus spp., Glossina spp., Haematopota spp., Hydrellia spp., Hydrellia griseola, Hylemya spp., Hippobosca spp., Hypoderma spp., Liriomyza spp., Lucilia spp., Lutzomyia spp., Mansonia spp., Musca spp., Oestrus spp., Oscinella frit, Paratanytarsus spp., Paralauterborniella subcincta, Pegomyia spp., Phlebotomus spp., Phorbia spp., Phormia spp., Piophila casei, Prodiplosis spp., Psila rosae, Rhagoletis spp., Sarcophaga spp., Simulium spp., Stomoxys spp., Tabanus spp., Tetanops spp., Tipula spp.;


from the order Heteroptera, for example, Anasa tristis, Antestiopsis spp., Boisea spp., Blissus spp., Calocoris spp., Campylomma livida, Cavelerius spp., Cimex spp., Collaria spp., Creontiades dilutus, Dasynus piperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus spp., Euschistus spp., Eurygaster spp., Heliopeltis spp., Horcias nobilellus, Leptocorisa spp., Leptocorisa varicornis, Leptoglossus phyllopus, Lygus spp., Macropes excavatus, Miridae, Monalonion atratum, Nezara spp., Oebalus spp., Pentomidae, Piesma quadrata, Piezodorus spp., Psallus spp., Pseudacysta persea, Rhodnius spp., Sahlbergella singularis, Scaptocoris castanea, Scotinophora spp., Stephanitis nashi, Tibraca spp., Triatoma spp.;


from the order Homoptera, for example, Acizzia acaciaebaileyanae, Acizzia dodonaeae, Acizzia uncatoides, Acrida turrita, Acyrthosipon spp., Acrogonia spp., Aeneolamia spp., Agonoscena spp., Aleyrodes proletella, Aleurolobus barodensis, Aleurothrixus floccosus, Allocaridara malayensis, Amrasca spp., Anuraphis cardui, Aonidiella spp., Aphanostigma pini, Aphis spp., Arboridia apicalis, Arytainilla spp., Aspidiella spp., Aspidiotus spp., Atanus spp., Aulacorthum solani, Bemisia tabaci, Blastopsylla occidentalis, Boreioglycaspis melaleucae, Brachycaudus helichrysi, Brachycolus spp., Brevicoryne brassicae, Cacopsylla spp., Calligypona marginata, Carneocephala fulgida, Ceratovacuna lanigera, Cercopidae, Ceroplastes spp., Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita onukii, Chondracris rosea, Chromaphis juglandicola, Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli, Coccus spp., Cryptomyzus ribis, Cryptoneossa spp., Ctenarytaina spp., Dalbulus spp., Dialeurodes citri, Diaphorina citri, Diaspis spp., Drosicha spp., Dysaphis spp., Dysmicoccus spp., Empoasca spp., Eriosoma spp., Erythroneura spp., Eucalyptolyma spp., Euphyllura spp., Euscelis bilobatus, Ferrisia spp., Geococcus coffeae, Glycaspis spp., Heteropsylla cubana, Heteropsylla spinulosa, Homalodisca coagulata, Hyalopterus arundinis, Icerya spp., Idiocerus spp., Idioscopus spp., Laodelphax striatellus, Lecanium spp., Lepidosaphes spp., Lipaphis erysimi, Macrosiphum spp., Macrosteles facifrons, Mahanarva spp., Melanaphis sacchari, Metcalfiella spp., Metopolophium dirhodum, Monellia costalis, Monelliopsis pecanis, Myzus spp., Nasonovia ribisnigri, Nephotettix spp., Nettigoniclla spectra, Nilaparvata lugens, Oncometopia spp., Orthezia praelonga, Oxya chinensis, Pachypsylla spp., Parabemisia myricae, Paratrioza spp., Parlatoria spp., Pemphigus spp., Peregrinus maidis, Phenacoccus spp., Phloeomyzus passerinii, Phorodon humuli, Phylloxera spp., Pinnaspis aspidistrae, Planococcus spp., Prosopidopsylla flava, Protopulvinaria pyriformis, Pseudaulacaspis pentagona, Pseudococcus spp., Psyllopsis spp., Psylla spp., Pteromalus spp., Pyrilla spp., Quadraspidiotus spp., Quesada gigas, Rastrococcus spp., Rhopalosiphum spp., Saissetia spp., Scaphoideus titanus, Schizaphis graminum, Selenaspidus articulatus, Sogata spp., Sogatella furcifera, Sogatodes spp., Stictocephala festina, Siphoninus phillyreae, Tenalaphara malayensis, Tetragonocephela spp., Tinocallis caryaefoliae, Tomaspis spp., Toxoptera spp., Trialeurodes vaporariorum, Trioza spp., Typhlocyba spp., Unaspis spp., Viteus vitifolii, Zygina spp.;


from the order Hymenoptera, for example, Acromyrmex spp., Athalia spp., Atta spp., Diprion spp., Hoplocampa spp., Lasius spp., Monomorium pharaonis, Sirex spp., Solenopsis invicta, Tapinoma spp., Urocerus spp., Vespa spp., Xeris spp.;


from the order Isopoda, for example, Armadillidium vulgare, Oniscus asellus, Porcellio scaber;


from the order Isoptera, for example, Coptotermes spp., Cornitermes cumulans, Cryptotermes spp., Incisitermes spp., Microtermes obesi, Odontotermes spp., Reticulitermes spp.;


from the order Lepidoptera, for example, Achroia grisella, Acronicta major, Adoxophyes spp., Aedia leucomelas, Agrotis spp., Alabama spp., Amyelois transitella, Anarsia spp., Anticarsia spp., Argyroploce spp., Barathra brassicae, Borbo cinnara, Bucculatrix thurberiella, Bupalus piniarius, Busseola spp., Cacoecia spp., Caloptilia theivora, Capua reticulana, Carpocapsa pomonella, Carposina niponensis, Chematobia brumata, Chilo spp., Choristoneura spp., Clysia ambiguella, Cnaphalocerus spp., Cnaphalocrocis medinalis, Cnephasia spp., Conopomorpha spp., Conotrachelus spp., Copitarsia spp., Cydia spp., Dalaca noctuides, Diaphania spp., Diatraea saccharalis, Earias spp., Ecdytolopha aurantium, Elasmopalpus lignosellus, Eldana saccharina, Ephestia spp., Epinotia spp., Epiphyas postvittana, Etiella spp., Eulia spp., Eupoecilia ambiguella, Euproctis spp., Euxoa spp., Feltia spp., Galleria mellonella, Gracillaria spp., Grapholitha spp., Hedylepta spp., Helicoverpa spp., Heliothis spp., Hofmannophila pseudospretella, Homoeosoma spp., Homona spp., Hyponomeuta padella, Kakivoria flavofasciata, Laphygma spp., Laspeyresia molesta, Leucinodes orbonalis, Leucoptera spp., Lithocolletis spp., Lithophane antennata, Lobesia spp., Loxagrotis albicosta, Lymantria spp., Lyonetia spp., Malacosoma neustria, Maruca testulalis, Mamstra brassicae, Melanitis leda, Mocis spp., Monopis obviella, Mythimna separata, Nemapogon cloacellus, Nymphula spp., Oiketicus spp., Oria spp., Orthaga spp., Ostrinia spp., Oulema oryzae, Panolis flammea, Parnara spp., Pectinophora spp., Perileucoptera spp., Phthorimaea spp., Phyllocnistis citrella, Phyllonorycter spp., Pieris spp., Platynota stultana, Plodia interpunctella, Plusia spp., Plutella xylostella, Prays spp., Prodenia spp., Protoparce spp., Pseudaletia spp., Pseudaletia unipuncta, Pseudoplusia includens, Pyrausta nubilalis, Rachiplusia nu, Schoenobius spp., Scirpophaga spp., Scirpophaga innotata, Scotia segetum, Sesamia spp., Sesamia inferens, Sparganothis spp., Spodoptera spp., Spodoptera praefica, Stathmopoda spp., Stomopteryx subsecivella, Synanthedon spp., Tecia solanivora, Thermesia gemmatalis, Tinea cloacella, Tinea pellionella, Tineola bisselliella, Tortrix spp., Trichophaga tapetzella, Trichoplusia spp., Tryporyza incertulas, Tuta absoluta, Virachola spp.;


from the order Orthoptera or Saltatoria, for example, Acheta domesticus, Dichroplus spp., Gryllotalpa spp., Hieroglyphus spp., Locusta spp., Melanoplus spp., Schistocerca gregaria;


from the order Phthiraptera, for example, Damalinia spp., Haematopinus spp., Linognathus spp., Pediculus spp., Ptirus pubis, Trichodectes spp.;


from the order Psocoptera for example Lepinatus spp., Liposcelis spp.;


from the order Siphonaptera, for example, Ceratophyllus spp., Ctenocephalides spp., Pulex irritans, Tunga penetrans, Xenopsylla cheopsis;


from the order Thysanoptera, for example, Anaphothrips obscurus, Baliothrips biformis, Drepanothrips reuteri, Enneothrips flavens, Frankliniella spp., Heliothrips spp., Hercinothrips femoralis, Rhipiphorothrips cruentatus, Scirtothrips spp., Taeniothrips cardamomi, Thrips spp.;


from the order Zygentoma (=Thysanura), for example, Ctenolepisma spp., Lepisma saccharina, Lepismodes inquilinus, Thermobia domestica;


from the class Symphyla, for example, Scutigerella spp.;


pests from the phylum Mollusca, especially from the class Bivalvia, for example, Dreissena spp., and from the class Gastropoda, for example, Anion spp., Biomphalaria spp., Bulinus spp., Deroceras spp., Galba spp., Lymnaea spp., Oncomelania spp., Pomacea spp., Succinea spp.;


animal pests from the phylums Plathelminthes and Nematoda, for example, Ancylostoma duodenale, Ancylostoma ceylanicum, Acylostoma braziliensis, Ancylostoma spp., Ascaris spp., Brugia malayi, Brugia timori, Bunostomum spp., Chabertia spp., Clonorchis spp., Cooperia spp., Dicrocoelium spp., Dictyocaulus filaria, Diphyllobothrium latum, Dracunculus medinensis, Echinococcus granulosus, Echinococcus multilocularis, Enterobius vermicularis, Faciola spp., Haemonchus spp., Heterakis spp., Hymenolepis nana, Hyostrongulus spp., Loa Loa, Nematodirus spp., Oesophagostomum spp., Opisthorchis spp., Onchocerca volvulus, Ostertagia spp., Paragonimus spp., Schistosomen spp., Strongyloides fuelleborni, Strongyloides stercoralis, Stronyloides spp., Taenia saginata, Taenia solium, Trichinella spiralis, Trichinella nativa, Trichinella britovi, Trichinella nelsoni, Trichinella pseudopsiralis, Trichostrongulus spp., Trichuris trichuria, Wuchereria bancroftiIt is furthermore possible to control organisms from the subphylum Protozoa, especially from the order Coccidia, such as Eimeria spp.


Nematodes


The active compounds of the formula (I) are particularly useful in controlling plant-parasitic nematodes in nematode-resistant plants wherein the nematodes are of the following species:



Aphelenchoides spp., Bursaphelenchus spp., Ditylenchus spp., Globodera spp., Heterodera spp., Longidorus spp., Meloidogyne spp., Pratylenchus spp., Radopholus spp., Trichodorus spp., Tylenchulus spp, Xiphinema spp., Helicotylenchus spp., Tylenchorhynchus spp., Scutellonema spp., Paratrichodorus spp., Meloinema spp., Paraphelenchus spp., Aglenchus spp., Belonolaimus spp., Nacobbus spp, Rotylenchulus spp., Rotylenchus spp., Neotylenchus spp., Paraphelenchus spp., Dolichodorus spp., Hoplolaimus spp., Punctodera spp., Criconemella spp., Quinisulcius spp., Hemicycliophora spp., Anguina spp., Subanguina spp., Hemicriconemoides spp., Psilenchus spp., Pseudohalenchus spp., Criconemoides spp., Cacopaurus spp



Aglenchus agricola, Anguina tritici, Aphelenchoides arachidis, Aphelenchoides fragariae, Belonolaimus gracilis, Belonolaimus longicaudatus, Belonolaimus nortoni, Cacopaurus pestis, Criconemella curvata, Criconemella onoensis, Criconemella ornata, Criconemella rusium, Criconemella xenoplax (=Mesocriconema xenoplax) and Criconemella spp. in general, Criconemoides ferniae, Criconemoides onoense, Criconemoides ornatum and Criconemoides spp. in general, Ditylenchus destructor, Ditylenchus dipsaci, Ditylenchus myceliophagus and Ditylenchus spp. in general, Dolichodorus heterocephalus, Globodera pallida (=Heterodera pallida), Globodera rostochiensis, Globodera solanacearum, Globodera tabacum, Globodera virginiae, Helicotylenchus digonicus, Helicotylenchus dihystera, Helicotylenchus erythrine, Helicotylenchus multicinctus, Helicotylenchus nannus, Helicotylenchus pseudorobustus and Helicotylenchus spp. in general, Hemicriconemoides, Hemicycliophora arenaria, Hemicycliophora nudata, Hemicycliophora parvana, Heterodera avenae, Heterodera cruciferae, Heterodera glycines, Heterodera oryzae, Heterodera schachtii, Heterodera zeae and Heterodera spp. in general, Hoplolaimus aegyptii, Hoplolaimus californicus, Hoplolaimus columbus, Hoplolaimus galeatus, Hoplolaimus indicus, Hoplolaimus magnistylus, Hoplolaimus pararobustus, Longidorus africanus, Longidorus breviannulatus, Longidorus elongatus, Longidorus laevicapitatus, Longidorus vineacola and Longidorus spp. in general, Meloidogyne acronea, Meloidogyne africana, Meloidogyne arenaria, Meloidogyne arenaria thamesi, Meloidogyne artiella, Meloidogyne chitwoodi, Meloidogyne coffeicola, Meloidogyne ethiopica, Meloidogyne exigua, Meloidogyne graminicola, Meloidogyne graminis, Meloidogyne hapla, Meloidogyne incognita, Meloidogyne incognita acrita, Meloidogyne javanica, Meloidogyne kikuyensis, Meloidogyne naasi, Meloidogyne paranaensis, Meloidogyne thamesi and Meloidogyne spp. in general, Meloinema spp., Nacobbus aberrans, Neotylenchus vigissi, Paraphelenchus pseudoparietinus, Paratrichodorus allius, Paratrichodorus lobatus, Paratrichodorus minor, Paratrichodorus nanus, Paratrichodorus porosus, Paratrichodorus teres and Paratrichodorus spp. in general, Paratylenchus hamatus, Paratylenchus minutus, Paratylenchus projectus and Paratylenchus spp. in general, Pratylenchus agilis, Pratylenchus alleni, Pratylenchus andinus, Pratylenchus brachyurus, Pratylenchus cerealis, Pratylenchus coffeae, Pratylenchus crenatus, Pratylenchus delattrei, Pratylenchus giibbicaudatus, Pratylenchus goodeyi, Pratylenchus hamatus, Pratylenchus hexincisus, Pratylenchus loosi, Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus pratensis, Pratylenchus scribneri, Pratylenchus teres, Pratylenchus thornei, Pratylenchus vulnus, Pratylenchus zeae and Pratylenchus spp. in general, Pseudohalenchus minutus, Psilenchus magnidens, Psilenchus tumidus, Punctodera chalcoensis, Quinisulcius acutus, Radopholus citrophilus, Radopholus similis, Rotylenchulus borealis, Rotylenchulus parvus, Rotylenchulus reniformis and Rotylenchulus spp. in general, Rotylenchus laurentinus, Rotylenchus macrodoratus, Rotylenchus robustus, Rotylenchus uniformis and Rotylenchus spp. in general, Scutellonema brachyurum, Scutellonema bradys, Scutellonema clathricaudatum and Scutellonema spp. in general, Subanguina radiciola, Tetylenchus nicotianae, Trichodorus cylindricus, Trichodorus minor, Trichodorus primitivus, Trichodorus proximus, Trichodorus similis, Trichodorus sparsus and Trichodorus spp. in general, Tylenchorhynchus agri, Tylenchorhynchus brassicae, Tylenchorhynchus clarus, Tylenchorhynchus claytoni, Tylenchorhynchus digitatus, Tylenchorhynchus ebriensis, Tylenchorhynchus maximus, Tylenchorhynchus nudus, Tylenchorhynchus vulgaris and Tylenchorhynchus spp. in general, Tylenchulus semipenetrans, Xiphinema americanum, Xiphinema brevicolle, Xiphinema dimorphicaudatum, Xiphinema index and Xiphinema spp


The methods according to the present invention have been found to provide a greater degree of plant vigor and yield in insect and nematode infested environments than would be expected from application of a biological or chemical control agent or the presence of an insect or nematode control gene alone. At least some of the insect or nematode control agents within the scope of the present invention have been shown to provide increased root mass even in the absence of insect pressure which increased root mass leads to improved establishment of the beneficial bacteria within the rhizosphere which, in turn, reduces overall losses in crop vigor and yields caused by insects. Along with the physical combination of these components while treating plants and plant material, in one preferred embodiment of this invention, the compositions of the present invention have been formulated to provide a stable environment for living biological control agents such as spore-forming, root-colonizing bacteria. Various additives may be added to each inventive composition depending on the desired properties for a final formulation which has the necessary physical and chemical stability to produce a commercially viable product.


The active compound combinations according to the invention can be present in commercial formulations and in the use forms prepared from these formulations as a mixture with other active compounds, such as insecticides, attractants, sterilants, bactericides, acaricides, nematicides, fungicides, growth regulators or herbicides. A mixture with fertilizers is also possible.


The treatment according to the invention of the plants and plant parts with the active compound combinations or compositions is carried out directly or by action on their surroundings, habitat or storage space using customary treatment methods, for example by dipping, spraying, atomizing, irrigating, evaporating, dusting, fogging, broadcasting, foaming, painting, spreading-on, watering (drenching), drip irrigating and, in the case of propagation material, in particular in the case of seeds, furthermore as a powder for dry seed treatment, a solution for seed treatment, a water-soluble powder for slurry treatment, by incrusting, by coating with one or more coats, etc. Preference is given to application by dipping, spraying, atomizing, irrigating, evaporating, dusting, fogging, broadcasting, foaming, painting, spreading-on, watering (drenching) and drip irrigating.


In the case of seed treatment, the treatment can be carried out by applying the compound of formula (I), or a combination of the compound of formula (I) with insecticides, fungicides, as a solution, a powder (for dry seed treatment), a water-soluble powder (for slurry seed treatment), or by incrusting, by coating with one or more layers containing the compound of formula (I).


Transgenic Plants


According to the invention all plants and plant parts can be treated. By plants is meant all plants and plant populations such as desirable and undesirable wild plants, cultivars and plant varieties (whether or not protectable by plant variety or plant breeder's rights). Cultivars and plant varieties can be plants obtained by conventional propagation and breeding methods which can be assisted or supplemented by one or more biotechnological methods such as by use of double haploids, protoplast fusion, random and directed mutagenesis, molecular or genetic markers or by bioengineering and genetic engineering methods or combinations of these methods, including the transgenic plants and including plant cultivars which can or cannot be protected by plant variety protection rights. By plant parts is meant all above ground and below ground parts and organs of plants such as shoot, leaf, blossom and root, whereby for example leaves, needles, stems, branches, trunks, flowers, blossoms, fruiting bodies, fruits and seed as well as roots, tubers, corms and rhizomes are listed. Crops and vegetative and generative propagating material, for example cuttings, corms, rhizomes, runners and seeds also belong to plant parts. Plant parts also include harvested material and vegetative and generative propagation material, for example seedlings, tubers, rhizomes, cuttings and seeds. Preference is given to the treatment of the plants and the above-ground and below-ground parts and organs of the plants, such as shoot, leaf, flower and root, examples which may be mentioned being leaves, needles, stems, trunks, flowers, and fruits.


Among the plants that can be protected by the method according to the invention, mention may be made of major field crops like corn, soybean, cotton, Brassica oilseeds such as Brassica napus (e.g. canola), Brassica rapa, B. juncea (e.g. mustard) and Brassica carinata, rice, wheat, sugarbeet, sugarcane, sorghum, oats, rye, barley, millet, triticale, flax, vine and various fruits and vegetables of various botanical taxa such as Rosaceae sp. (for instance pip fruit such as apples and pears, but also stone fruit such as apricots, cherries, almonds and peaches, berry fruits such as strawberries), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actimidaceae sp., Lauraceae sp., Musaceae sp. (for instance banana trees and plantings), Rubiaceae sp. (for instance coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons, oranges and grapefruit); Solanaceae sp. (for instance tomatoes, potatoes, peppers, eggplant), Liliaceae sp., Compositiae sp. (for instance lettuce, artichoke and chicory—including root chicory, endive or common chicory), Umbelliferae sp. (for instance carrot, parsley, celery and celeriac), Cucurbitaceae sp. (for instance cucumber—including pickling cucumber, squash, watermelon, gourds and melons), Alliaceae sp. (for instance onions and leek), Cruciferae sp. (for instance white cabbage, red cabbage, broccoli, cauliflower, brussel sprouts, pak choi, kohlrabi, radish, horseradish, cress, Chinese cabbage), Leguminosae sp. (for instance peanuts, peas and beans beans—such as climbing beans and broad beans), Chenopodiaceae sp. (for instance mangold, spinach beet, spinach, beetroots), Malvaceae (for instance okra), Asparagaceae (for instance asparagus); horticultural and forest crops; ornamental plants; as well as genetically modified homologues of these crops.


In particular, a compound of the formula (I) or a composition comprising a compound of the formula (I) and a further agrochemical active ingredient can be used according to the invention for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic corn, soybean, cotton, rice, oilseed rape, sugar cane, sugar beet, potatoes, vegetables, in particular tomatoes and curcurbits, tobacco, coffee, and fruits.


The method of treatment according to the invention can be used in the treatment of genetically modified organisms (GMOs), e.g. plants or seeds. Genetically modified plants (or transgenic plants) are plants of which a heterologous gene has been stably integrated into the genome. The expression “heterologous gene” essentially means a gene which is provided or assembled outside the plant and when introduced in the nuclear, chloroplastic or mitochondrial genome gives the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of interest or by downregulating or silencing other gene(s) which are present in the plant (using for example, antisense technology, cosuppression technology, RNA interference—RNAi—technology or microRNA—miRNA—technology). A heterologous gene that is located in the genome is also called a transgene. A transgene that is defined by its particular location in the plant genome is called a transformation or transgenic event.


Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, diet), the treatment according to the invention may also result in superadditive (“synergistic”) effects. Thus, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the active compounds and compositions which can be used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, bigger fruits, larger plant height, greener leaf color, earlier flowering, higher quality and/or a higher nutritional value of the harvested products, higher sugar concentration within the fruits, better storage stability and/or processability of the harvested products are possible, which exceed the effects which were actually to be expected.


At certain application rates, the active compound or active compound combinations according to the invention may also have a strengthening effect in plants. Accordingly, they are also suitable for mobilizing the defense system of the plant against attack by unwanted microorganisms. This may, if appropriate, be one of the reasons of the enhanced activity of the combinations according to the invention, for example against insects or nematodes. Plant-strengthening (resistance-inducing) substances are to be understood as meaning, in the present context, those substances or combinations of substances which are capable of stimulating the defense system of plants in such a way that, when subsequently inoculated with unwanted microorganisms, the treated plants display a substantial degree of resistance to these microorganisms. In the present case, unwanted microorganisms are to be understood as meaning phytopathogenic fungi, bacteria and viruses. Thus, the substances according to the invention can be employed for protecting plants against attack by the abovementioned pathogens within a certain period of time after the treatment. The period of time within which protection is effected generally extends from 1 to 10 days, preferably 1 to 7 days, after the treatment of the plants with the active compounds.


Plants and plant cultivars which are preferably to be treated according to the invention include all plants which have genetic material which impart particularly advantageous, useful traits to these plants (whether obtained by breeding and/or biotechnological means).


Plants and plant cultivars which are also preferably to be treated according to the invention are resistant against one or more biotic stresses, i.e. said plants show a better defense against animal and microbial pests, such as against nematodes, insects, mites, phytopathogenic fungi, bacteria, viruses and/or viroids.


Examples of nematode or insect resistant plants are described in the following patent applications: U.S. Ser. No. 11/765,491, U.S. Ser. No. 11/765,494, U.S. Ser. No. 10/926,819, U.S. Ser. No. 10/782,020, U.S. Ser. No. 12/032,479, U.S. Ser. No. 10/783,417, U.S. Ser. No. 10/782,096, U.S. Ser. No. 11/657,964, U.S. Ser. No. 12/192,904, U.S. Ser. No. 11/396,808, U.S. Ser. No. 12/166,253, U.S. Ser. No. 12/166,239, U.S. Ser. No. 12/166,124, U.S. Ser. No. 12/166,209, U.S. Ser. No. 11/762,886, U.S. Ser. No. 12/364,335, U.S. Ser. No. 11/763,947, U.S. Ser. No. 12/252,453, U.S. Ser. No. 12/209,354, U.S. Ser. No. 12/491,396 U.S. Ser. No. 12/497,221, U.S. Ser. No. 12/644,632, U.S. Ser. No. 12/646,004, U.S. Ser. No. 12/701,058, U.S. Ser. No. 12/718,059, U.S. Ser. No. 12/721,595, U.S. Ser. No. 12/638,591, U.S. Ser. No. 12/249,016, U.S. Ser. No. 12/828,594, WO2009/027539A2, WO2009/027313A2, WO2008/152008A2, WO2008/110522A1, WO2008/095972A1, WO2008/095970A1, WO2008/095969A1, WO2008/095919A1, WO2008/095916A1, WO2008/095911A2, WO2008/095910A1, WO2008/095889A1, WO2008/095886A1, WO2008/077892A1, WO2008/071726A2, WO2006/020821A2, WO2005/082932A2, WO2009/048847A1, WO2007/095469A2, WO2005/012340A1, WO2007/104570A2.


Genes described as nematode control genes are listed in Table I. The nucleotide and amino acid sequence information of these nematode control genes are represented by the SEQ ID NOs listed in columns 4 and 5 of Table 1 with respect to the United States patent application Serial No. listed in column 2 of Table I.













TABLE I






U.S. APPLICATION
FILING
NUCLEOTIDE
AMINO ACID


GENE NAME
SERIAL NO.
DATE
SEQ ID NO
SEQ ID NO







axmi205
12/828,594
Jul. 1, 2010
 1
2, 3, 4, 5,






6, 7, 8


optaxmi205v01.03
12/828,594
Jul. 1, 2010
10
2


optaxmi205v01.02
12/828,594
Jul. 1, 2010
 9
2


optaxmi205v01.04
12/828,594
Jul. 1, 2010
11
2


optaxmiR1(evo 21)
12/701,058
Feb. 5, 2010
12
13 


optaxmiR1(evo 22)
12/701,058
Feb. 5, 2010
14
15 


optaxmiR1(evo 23)
12/701,058
Feb. 5, 2010
16
17 


optaxmiR1(evo 26)
12/701,058
Feb. 5, 2010
18
19 


optaxmi115v01
12/497,221
Jul. 2, 2009
15
6


optaxmi115v02
12/497,221
Jul. 2, 2009
16
6


axmi115v02
61/471,848
Apr. 5, 2011
any of 1-14
any of 15-31


axmi100
12/491,396
Jun. 25, 2009
36, 282
96 


axmi076
12/252,453
Oct. 16, 2008
4, 6, 11
5


axmi005
12/497,221
Jul. 2, 2009
1,7
4, 9


optcry1Ac
12/249,016
Oct. 10, 2008
1, 2, 3, 4, 5
6


axmi031
11/762,886
Jun. 14, 2007
20
21 


axn2
12/638,591
Dec. 15, 2009
7, 10
8









Plants and plant cultivars which may also be treated according to the invention are those plants which are resistant to one or more abiotic stresses. Abiotic stress conditions may include, for example, drought, cold temperature exposure, heat exposure, osmotic stress, flooding, increased soil salinity, increased mineral exposure, ozone exposure, high light exposure, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients, shade avoidance.


Plants and plant cultivars which may also be treated according to the invention, are those plants characterized by enhanced yield characteristics. Increased yield in said plants can be the result of, for example, improved plant physiology, growth and development, such as water use efficiency, water retention efficiency, improved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination efficiency and accelerated maturation. Yield can furthermore be affected by improved plant architecture (under stress and non-stress conditions), including but not limited to, early flowering, flowering control for hybrid seed production, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed dispersal, reduced pod dehiscence and lodging resistance. Further yield traits include seed composition, such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction in anti-nutritional compounds, improved processability and better storage stability.


Examples of plants with the above-mentioned traits are non-exhaustively listed in Table A.









TABLE A







Non-exclusive list of transgenic plants and events for the design of experiments with the compound


of formula (I) related to the invention (source: (AGBIOS, P.O. Box 475, 106 St. John St. Merrickville,


Ontario K0G1N0, CANADA) accessible under: http://www.agbios.com/dbase.php.













Event
Company
Description
Crop
Patent Ref
















A-1
ASR-368
Scotts Seeds
Glyphosate tolerance derived

Agrostis

US 2006-





by inserting a modified 5-

stolonifera

162007





enolpyruvylshikimate-3-
Creeping





phosphate synthase (EPSPS)
Bentgrass





encoding gene from






Agrobacterium tumefaciens,





parent line B99061


A-2
GM
Syngenta
Beet Necrotic Yellow Vein

Beta vulgaris

WO2010076212



RZ13
International
Virus (BNYVV) resistance
(sugar beet)




AG


A-3
GTSB77
Novartis
Glyphosate herbicide tolerant

Beta vulgaris





Seeds;
sugar beet produced by
(sugar beet)




Monsanto
inserting a gene encoding the




Company
enzyme 5-





enolypyruvylshikimate-3-





phosphate synthase (EPSPS)





from the CP4 strain of






Agrobacterium tumefaciens.


A-4
H7-1
Monsanto
Glyphosate herbicide tolerant

Beta vulgaris

WO 2004-




Company
sugar beet produced by
(sugar beet)
074492





inserting a gene encoding the





enzyme 5-





enolypyruvylshikimate-3-





phosphate synthase (EPSPS)





from the CP4 strain of






Agrobacterium tumefaciens



A-5
T120-7
Bayer
Introduction of the PPT-

Beta vulgaris





Crop Science
acetyltransferase (PAT)
(sugar beet)




(Aventis
encoding gene from




CropScience(AgrEvo))

Streptomyces







viridochromogenes, an





aerobic soil bacteria. PPT





normally acts to inhibit





glutamine synthetase, causing





a fatal accumulation of





ammonia. Acetylated PPT is





inactive.


A-6
T227-1
WEYENS G;
Glyphosate tolerance

Beta vulgaris

US 2004-




BARNES S;

(sugar beet)
117870




ROSQUIN I;




SES




EUROPE




N.V./S.A


A-7
23-18-17,
Monsanto
High laurate (12:0) and

Brassica




23-198
Company
myristate (14:0) canola

napus (Argen-




(formerly
produced by inserting a
tine Canola)




Calgene)
thioesterase encoding gene





from the California bay laurel





(Umbellularia californica).


A-8
45A37,
Pioneer Hi-
High oleic acid and low

Brassica




46A40
Bred
linolenic acid canola

napus (Argen-




International
produced through a
tine Canola)




Inc.
combination of chemical





mutagenesis to select for a





fatty acid desaturase mutant





with elevated oleic acid, and





traditional back-crossing to





introduce the low linolenic





acid trait.


A-9
46A12,
Pioneer Hi-
Combination of chemical

Brassica




46A16
Bred
mutagenesis, to achieve the

napus (Argen-




International
high oleic acid trait, and
tine Canola)




Inc.
traditional breeding with





registered canola varieties.


A-10
GT200
Monsanto
Glyphosate herbicide tolerant

Brassica





Company
canola produced by inserting

napus (Argen-





genes encoding the enzymes
tine Canola)





5-enolypyruvylshikimate-3-





phosphate synthase (EPSPS)





from the CP4 strain of






Agrobacterium tumefaciens






and glyphosate oxidase from






Ochrobactrum anthropi.


A-11
GT73,
Monsanto
Glyphosate herbicide tolerant

Brassica




RT73
Company
canola produced by inserting

napus (Argen-





genes encoding the enzymes
tine Canola)





5-enolypyruvylshikimate-3-





phosphate synthase (EPSPS)





from the CP4 strain of






Agrobacterium tumefaciens






and glyphosate oxidase from






Ochrobactrum anthropi.


A-12
HCN10
Aventis
Introduction of the PPT-

Brassica





CropScience
acetyltransferase (PAT)

napus (Argen-





encoding gene from
tine Canola)






Streptomyces







viridochromogenes, an





aerobic soil bacteria. PPT





normally acts to inhibit





glutamine synthetase, causing





a fatal accumulation of





ammonia. Acetylated PPT is





inactive.


A-13
HCN92
Bayer
Introduction of the PPT-

Brassica





Crop Science
acetyltransferase (PAT)

napus (Argen-




(Aventis
encoding gene from
tine Canola)




CropScience(AgrEvo))

Streptomyces







viridochromogenes, an





aerobic soil bacteria. PPT





normally acts to inhibit





glutamine synthetase, causing





a fatal accumulation of





ammonia. Acetylated PPT is





inactive.


A-14
MS1,
Aventis
Male-sterility, fertility

Brassica




RF1 =>
Crop Science
restoration, pollination

napus (Argen-



PGS1
(formerly
control system displaying
tine Canola)




Plant Genetic
glufosinate herbicide




Systems)
tolerance. MS lines contained





the barnase gene from






Bacillus amyloliquefaciens,





RF lines contained the barstar





gene from the same bacteria,





and both lines contained the





phosphinothricin N-





acetyltransferase (PAT)





encoding gene from






Streptomyces hygroscopicus.


A-15
MS1,
Aventis
Male-sterility, fertility

Brassica




RF2 =>
CropScience
restoration, pollination

napus (Argen-



PGS2
(formerly
control system displaying
tine Canola)




Plant Genetic
glufosinate herbicide




Systems)
tolerance. MS lines contained





the barnase gene from






Bacillus amyloliquefaciens,





RF lines contained the barstar





gene from the same bacteria,





and both lines contained the





phosphinothricin N-





acetyltransferase (PAT)





encoding gene from






Streptomyces hygroscopicus.


A-16
MS8xRF3
Bayer
Male-sterility, fertility

Brassica





CropScience
restoration, pollination

napus (Argen-




(Aventis
control system displaying
tine Canola)




CropScience(AgrEvo))
glufosinate herbicide





tolerance. MS lines contained





the barnase gene from






Bacillus amyloliquefaciens,





RF lines contained the barstar





gene from the same bacteria,





and both lines contained the





phosphinothricin N-





acetyltransferase (PAT)





encoding gene from






Streptomyces hygroscopicus.


A-17
MS-B2
AVENTIS
Male sterility

Brassica

WO




CROPSCIENCE


napus (Argen-
01/31042




N.V.

tine Canola)


A-18
MS-
AVENTIS
Male sterility/restoration

Brassica

WO



BN1/RF-
CROPSCIENCE


napus (Argen-
01/41558



BN1
N.V.

tine Canola)


A-19
NS738,
Pioneer Hi-
Selection of somaclonal

Brassica




NS1471,
Bred
variants with altered

napus (Argen-



NS1473
International
acetolactate synthase (ALS)
tine Canola)




Inc.
enzymes, following chemical





mutagenesis. Two lines





(P1, P2) were initially selected





with modifications at





different unlinked loci.





NS738 contains the P2





mutation only.


A-20
OXY-235
Aventis
Tolerance to the herbicides

Brassica





CropScience
bromoxynil and ioxynil by

napus (Argen-




(formerly
incorporation of the nitrilase
tine Canola)




Rhone
gene from Klebsiella




Poulenc Inc.)

pneumoniae.


A-21
PHY14,
Aventis
Male sterility was via

Brassica




PHY35
CropScience
insertion of the barnase

napus (Argen-




(formerly
ribonuclease gene from
tine Canola)




Plant Genetic

Bacillus amyloliquefaciens;




Systems)
fertility restoration by





insertion of the barstar RNase





inhibitor; PPT resistance was





via PPT-acetyltransferase





(PAT) from Streptomyces






hygroscopicus.


A-22
PHY36
Aventis
Male sterility was via

Brassica





CropScience
insertion of the barnase

napus (Argen-




(formerly
ribonuclease gene from
tine Canola)




Plant Genetic

Bacillus amyloliquefaciens;




Systems)
fertility restoration by





insertion of the barstar RNase





inhibitor; PPT resistance was





via PPT-acetyltransferase





(PAT) from Streptomyces






hygroscopicus.


A-23
RT73
MONSANTO
Glyphosate resistance

Brassica

WO




TECHNOLOGY


napus (Argen-
02/36831




LLC

tine Canola)


A-24
T45
Bayer
Introduction of the PPT-

Brassica




(HCN28)
CropScience
acetyltransferase (PAT)

napus (Argen-




(Aventis
encoding gene from
tine Canola)




CropScience(AgrEvo))

Streptomyces







viridochromogenes, an





aerobic soil bacteria. PPT





normally acts to inhibit





glutamine synthetase, causing





a fatal accumulation of





ammonia. Acetylated PPT is





inactive.


A-25
HCR-1
Bayer
Introduction of the

Brassica





CropScience
glufosinate ammonium

rapa (Polish




(Aventis
herbicide tolerance trait from
Canola)




CropScience(AgrEvo))
transgenic B. napus line T45.





This trait is mediated by the





phosphinothricin





acetyltransferase (PAT)





encoding gene from S.






viridochromogenes.


A-26
ZSR500/
Monsanto
Introduction of a modified 5-

Brassica




502
Company
enol-pyruvylshikimate-3-

rapa (Polish





phosphate synthase (EPSPS)
Canola)





and a gene from






Achromobacter sp that





degrades glyphosate by





conversion to





aminomethylphosphonic acid





(AMPA) and glyoxylate by





interspecific crossing with





GT73.


A-27
EE-1
MAHARASHTRA
Insect resistance (Cry1Ac)
Brinjal
WO




HYBRID


2007/091277




SEEDS




COMPANY




LIMITED




(MAHYCO)


A-28
55-1/63-
Cornell
Papaya ringspot virus (PRSV)

Carica




1
University
resistant papaya produced by

papaya (Papa-





inserting the coat protein (CP)
ya)





encoding sequences from this





plant potyvirus.


A-29
X17-2
University of
Papaya ringspot virus (PRSV)

Carica





Florida
resistant papaya produced by

papaya (Papa-





inserting the coat protein (CP)
ya)





encoding sequences from





PRSV isolate H1K with a





thymidine inserted after the





initiation codon to yield a





frameshift. Also contains





nptII as a selectable marker.


A-30
RM3-3,
Bejo Zaden
Male sterility was via

Cichorium




RM3-4,
BV
insertion of the barnase

intybus (Chic-



RM3-6

ribonuclease gene from
ory)






Bacillus amyloliquefaciens;





PPT resistance was via the





bar gene from S.






hygroscopicus, which





encodes the PAT enzyme.


A-31
A, B
Agritope Inc.
Reduced accumulation of S-

Cucumis






adenosylmethionine (SAM),

melo (Melon)





and consequently reduced





ethylene synthesis, by





introduction of the gene





encoding S-





adenosylmethionine





hydrolase.


A-32
CZW-3
Asgrow
Cucumber mosiac virus

Cucurbita





(USA);
(CMV), zucchini yellows

pepo (Squash)




Seminis
mosaic (ZYMV) and




Vegetable
watermelon mosaic virus




Inc. (Canada)
(WMV) 2 resistant squash





(Curcurbita pepo) produced by





inserting the coat protein (CP)





encoding sequences from





each of these plant viruses





into the host genome.


A-33
ZW20
Upjohn
Zucchini yellows mosaic

Cucurbita





(USA);
(ZYMV) and watermelon

pepo (Squash)




Seminis
mosaic virus (WMV) 2




Vegetable
resistant squash (Curcurbita




Inc. (Canada)

pepo) produced by inserting





the coat protein (CP)





encoding sequences from





each of these plant





potyviruses into the host





genome.


A-34
66
Florigene Pty
Delayed senescence and

Dianthus





Ltd.
sulfonylurea herbicide

caryophyllus






tolerant carnations produced
(Carnation)





by inserting a truncated copy





of the carnation





aminocyclopropane cyclase





(ACC) synthase encoding





gene in order to suppress





expression of the endogenous





unmodified gene, which is





required for normal ethylene





biosynthesis. Tolerance to





sulfonyl urea herbicides was





via the introduction of a





chlorsulfuron tolerant version





of the acetolactate synthase





(ALS) encoding gene from





tobacco.


A-35
4, 11, 15,
Florigene Pty
Modified colour and

Dianthus




16
Ltd.
sulfonylurea herbicide

caryophyllus






tolerant carnations produced
(Carnation)





by inserting two anthocyanin





biosynthetic genes whose





expression results in a





violet/mauve





colouration. Tolerance to





sulfonyl urea herbicides was





via the introduction of a





chlorsulfuron tolerant version





of the acetolactate synthase





(ALS) encoding gene from





tobacco.


A-36
959A,
Florigene Pty
Introduction of two

Dianthus




988A,
Ltd.
anthocyanin biosynthetic

caryophyllus




1226A,

genes to result in a
(Carnation)



1351A,

violet/mauve colouration;



1363A,

Introduction of a variant form



1400A

of acetolactate synthase





(ALS).


A-37
127
BASF
ALS/AHAS inhibitor-

Glycine max

WO2010080829




AGROCHEMICAL
tolerance
L. (Soybean)




PRODUCTS




B.V.


A-38
3560.4.3.5
PIONEER
Glyphosate/ALS inhibitor-

Glycine max

WO




HI-BRED
tolerance
L. (Soybean)
2008002872,




INTERNATIONAL,


US2010184079




INC


A-39
A2704-
Bayer
Glufosinate ammonium

Glycine max

WO



12,
CropScience
herbicide tolerant soybean
L. (Soybean)
2006/108674



A2704-
(Aventis
produced by inserting a



21
CropScience(AgrEvo))
modified phosphinothricin





acetyltransferase (PAT)





encoding gene from the soil





bacterium Streptomyces






viridochromogenes



A-40
A5547-
Bayer
Glufosinate ammonium

Glycine max




127
CropScience
herbicide tolerant soybean
L. (Soybean)




(Aventis
produced by inserting a




CropScience(AgrEvo))
modified phosphinothricin





acetyltransferase (PAT)





encoding gene from the soil





bacterium Streptomyces






viridochromogenes.


A-41
A5547-
Bayer
Glufosinate tolerance

Glycine max

WO



35
CropScience

L. (Soybean)
2006/108675




(Aventis




CropScience(AgrEvo))


A-42
DP-
Pioneer Hi-
High oleic acid/ALS

Glycine max

WO



305423-1
Bred
inhibitor tolerance
L. (Soybean)
2008/054747




International




Inc.


A-43
DP356043
Pioneer Hi-
Soybean event with two

Glycine max





Bred
herbicide tolerance genes:
L. (Soybean)




International
glyphosate N-




Inc.
acetlytransferase, which





detoxifies glyphosate, and a





modified acetolactate





synthase (A


A-44
G94-1,
DuPont
High oleic acid soybean

Glycine max




G94-19,
Canada
produced by inserting a
L. (Soybean)



G168
Agricultural
second copy of the fatty acid




Products
desaturase (GmFad2-1)





encoding gene from soybean,





which resulted in “silencing”





of the endogenous host gene.


A-45
GTS 40-3-2
Monsanto
Glyphosate tolerant soybean

Glycine max





Company
variety produced by inserting
L. (Soybean)





a modified 5-





enolpyruvylshikimate-3-





phosphate synthase (EPSPS)





encoding gene from the soil





bacterium Agrobacterium






tumefaciens.


A-46
GU262
Bayer
Glufosinate ammonium

Glycine max





CropScience
herbicide tolerant soybean
L. (Soybean)




(Aventis
produced by inserting a




CropScience(AgrEvo))
modified phosphinothricin





acetyltransferase (PAT)





encoding gene from the soil





bacterium Streptomyces






viridochromogenes.


A-47
MON87701
Monsanto
insect resistance (CryIac)

Glycine max

WO




Company

L. (Soybean)
2009064652


A-48
MON87705
Monsanto
altered fatty acid levels (mid-

Glycine max

WO




Company
oleic and low saturate)
L. (Soybean)
2010037016


A-49
MON87754
Monsanto
increased oil content

Glycine max

WO




Company

L. (Soybean)
2010024976


A-50
MON87769
Monsanto
stearidonic acid (SDA)

Glycine max

WO




Company
comprising oil
L. (Soybean)
2009102873


A-51
MON89788
Monsanto
Glyphosate-tolerant soybean

Glycine max

WO2006130436




Company
produced by inserting a
L. (Soybean)





modified 5-





enolpyruvylshikimate-3-





phosphate synthase (EPSPS)





encoding aroA (epsps) gene





from Agrobacterium






tumefaciens CP4


A-52
MON19788
Monsanto
Glyphosate tolerance

Glycine max

WO2006130436




Company

L. (Soybean)


A-53
OT96-15
Agriculture
Low linolenic acid soybean

Glycine max





& Agri-Food
produced through traditional
L. (Soybean)




Canada
cross-breeding to incorporate





the novel trait from a





naturally occurring fan1 gene





mutant that was selected for





low linolenic acid.


A-54
W62,
Bayer
Glufosinate ammonium

Glycine max




W98
CropScience
herbicide tolerant soybean
L. (Soybean)




(Aventis
produced by inserting a




CropScience(AgrEvo))
modified phosphinothricin





acetyltransferase (PAT)





encoding gene from the soil





bacterium Streptomyces






hygroscopicus.


A-55
MON87708
MONSANTO
Dicamba herbicide tolerance,

Glycine max

WO 2011034704




TECHNOLOGY
transformation vector PV-
L. (Soybean)




LLC
GMHT4355 1) DMO: full





length transcript (Peanut





Chlorotic Streak Virus)





promoter > tobacco Etch





Virus leader > ribulose 1,5-





biphosphate carboxylase





small subunit (Pisum






sativum) chloroplast transit





peptide > dicamba mono-





oxygenase





(Stenotrophomonas






maltophilia) coding sequence >





ribulose-1,5-bisphosphate





carboxylase small subunit E9





(Pisum sativum) 3′-





untranslated region. A CP4





epsps chimeric gene





contained within a second T-





DNA on the transformation





vector used was segregated





away.


A-56
EE-GM3/FG72
BAYER
1) Ph4a748 ABBC: sequence

Glycine max

WO 2011063411




BIOSCIENCE
including the promoter region
L. (Soybean)




NV [BE];
of the histone H4 gene of




MS

Arabidopsis thaliana,




TECHNOLOGIES
containing an internal




LLC [US]
duplication>5′tev: sequence





including the leader sequence





of the tobacco etch





virus>TPotp Y: coding





sequence of an optimized





transit peptide derivative





(position 55 changed into





Tyrosine), containing





sequence of the RuBisCO





small subunit genes of Zea






mays (corn) and Helianthus






annuus (sunflower)>hppdPf





W336: the coding sequence





of the 4-





hydroxyphenylpyruvate





dioxygenase of Pseudomonas






fluorescens strain A32





modified by the replacement





of the amino acid Glycine





336 with a





Tryptophane>3′nos: sequence





including the 3′ untranslated





region of the nopaline





synthase gene from the T-





DNA of pTiT37 of






Agrobacterium tumefaciens.





2) Ph4a748: sequence





including the promoter region





of the histone H4 gene of






Arabidopsis thaliana>intron1





h3At: first intron of gene II of





the histone H3.III variant of






Arabidopsis thaliana >TPotp





C: coding sequence of the





optimized transit peptide,





containing sequence o


A-57
416/
DOW
A novel aad-12

Glycine max

WO



pDAB44
AGROSCIENCES
transformation event for
L. (Soybean)
2011066384,



68-0416
LLC
herbicide tolerance in

WO





soybean plants - referred to

2007/053482.





herein as pDAB4468-0416.





The aad-12 gene (originally





from Delftia acidovorans)





encodes the aryloxyalkanoate





dioxygenase (AAD-12)





protein. The trait confers





tolerance to 2,4-





dichlorophenoxyacetic acid,





for example, and to





pyridyloxyacetate herbicides.





The aad-12 gene, itself, for





herbicide tolerance in plants


A-58
15985
Monsanto
Insect resistant cotton derived

Gossypium





Company
by transformation of the

hirsutum






DP50B parent variety, which
L. (Cotton)





contained event 531





(expressing Cry1Ac protein),





with purified plasmid DNA





containing the cry2Ab gene





from B. thuringiensis subsp.






kurstaki.


A-59
1143-
SYNGENTA
Insect resistance (Cry1Ab)

Gossypium

WO



14A
PARTICIPA-


hirsutum

2006/128569




TIONS AG

L. (Cotton)


A-60
1143-
SYNGENTA
Insect resistance (Cry1Ab)

Gossypium

WO



51B
PARTICIPA-


hirsutum

2006/128570




TIONS AG

L. (Cotton)


A-61
19-51A
DuPont
Introduction of a variant form

Gossypium





Canada
of acetolactate synthase

hirsutum





Agricultural
(ALS).
L. (Cotton)




Products


A-62
281-24-
DOW
Insect-resistant cotton

Gossypium




236
AgroSciences
produced by inserting the

hirsutum





LLC
cry1F gene from Bacillus
L. (Cotton)






thuringiensis var. aizawai. The





PAT encoding gene from






Streptomyces







viridochromogenes was





introduced as a selectable





marker.


A-63
3006-
DOW
Insect-resistant cotton

Gossypium




210-23
AgroSciences
produced by inserting the

hirsutum





LLC
cry1Ac gene from Bacillus
L. (Cotton)






thuringiensis subsp. kurstaki.





The PAT encoding gene from






Streptomyces







viridochromogenes was





introduced as a selectable





marker.


A-64
31807/31808
Calgene Inc.
Insect-resistant and

Gossypium






bromoxynil herbicide tolerant

hirsutum






cotton produced by inserting
L. (Cotton)





the cry1Ac gene from






Bacillus thuringiensis and a





nitrilase encoding gene from






Klebsiella pneumoniae.


A-65
BXN
Calgene Inc.
Bromoxynil herbicide tolerant

Gossypium






cotton produced by inserting

hirsutum






a nitrilase encoding gene
L. (Cotton)





from Klebsiella pneumoniae.


A-66
CE43-
SYNGENTA
Insect resistance (Cry1Ab)

Gossypium

WO



67B
PARTICIPA-


hirsutum

2006/128573,




TIONS AG

L. (Cotton)
US







2011020828


A-67
CE44-
SYNGENTA
Insect resistance (Cry1Ab)

Gossypium

WO



69D
PARTICIPA-


hirsutum

2006/128571




TIONS AG

L. (Cotton)


A-68
CE46-
SYNGENTA
Insect resistance (Cry1Ab)

Gossypium

WO



02A
PARTICIPA-


hirsutum

2006/128572




TIONS AG

L. (Cotton)


A-69
Cot102
Syngenta
Insect-resistant cotton

Gossypium

US 2006-




Seeds, Inc.
produced by inserting the

hirsutum

130175,





vip3A(a) gene from Bacillus
L. (Cotton)
WO2004039986,






thuringiensisAB88. The

US





APH4 encoding gene from E.

2010298553






coli was introduced as a





selectable marker


A-70
COT202
Syngenta
Insect resistance (VIP3A)

Gossypium

US2009181399




Seeds, Inc.


hirsutum







L. (Cotton)


A-71
Cot202
Syngenta
Insect resistance (VIP3)

Gossypium

US 2007-




Seeds, Inc.


hirsutum

067868






L. (Cotton)


A-72
Cot67B
Syngenta
Insect-resistant cotton

Gossypium





Seeds, Inc.
produced by inserting a full-

hirsutum






length cry1Ab gene from
L. (Cotton)






Bacillus thuringiensis. The





APH4 encoding gene from E.






coli was introduced as a





selectable marker.


A-73
DAS-
DOW
WideStrike ™, a stacked

Gossypium




21Ø23-5 ×
AgroSciences
insect-resistant cotton derived

hirsutum




DAS-
LLC
from conventional cross-
L. (Cotton)



24236-5

breeding of parental lines





3006-210-23 (OECD





identifier: DAS-21Ø023-5) and





281-24-236 (OECD





identifier: DAS-24236-5).


A-74
DAS-
DOW
Stacked insect-resistant and

Gossypium




21Ø23-5 ×
AgroSciences
glyphosate-tolerant cotton

hirsutum




DAS-
LLC and
derived from conventional
L. (Cotton)



24236-5 ×
Pioneer Hi-
cross-breeding of WideStrike



MON88913
Bred
cotton (OECD identifier:




International
DAS-21Ø23-5 × DAS-24236-




Inc.
5) with MON88913, known





as RoundupReady Flex





(OECD identifier: MON-





88913-8).


A-75
DAS-
DOW
WideStrike ™/Roundup

Gossypium




21Ø23-5 ×
AgroSciences
Ready ® cotton, a stacked

hirsutum




DAS-
LLC
insect-resistant and
L. (Cotton)



24236-5 ×

glyphosate-tolerant cotton



MON-

derived from conventional



Ø1445-2

cross-breeding of WideStrike





cotton (OECD identifier:





DAS-21Ø23-5 × DAS-24236-





5) with MON1445 (OECD





identifier: MON-Ø1445-2).


A-76
EE-GH3
BAYER
Glyphosate tolerance

Gossypium

WO




BIOSCIENCE


hirsutum

2007/017186




N.V.

L. (Cotton)


A-77
EE-GH5
BAYER
Insect resistance (Cry1Ab)

Gossypium

WO




BIOSCIENCE


hirsutum

2008/122406




N.V.

L. (Cotton)


A-78
EE-GH6
BAYER
Insect resistance (cry2Ae)

Gossypium

WO2008151780,




BIOSCIENCE


hirsutum

US2010218281




N.V.

L. (Cotton)


A-79
event
DOW
Insect resistance (Cry1F)

Gossypium

WO



281-24-
AGROSCIENCES


hirsutum

2005/103266



236
LLC

L. (Cotton)


A-80
Event-1
JK Agri
Insect-resistant cotton

Gossypium





Genetics Ltd
produced by inserting the

hirsutum





(India)
cry1Ac gene from Bacillus
L. (Cotton)






thuringiensis subsp. kurstaki





HD-73 (B.t.k.).


A-81
event300
DOW
Insect resistance (Cry1Ac)

Gossypium

WO



6-210-23
AGROSCIENCES


hirsutum

2005/103266




LLC

L. (Cotton)


A-82
GBH614
Bayer
Glyphosate herbicide tolerant

Gossypium





CropScience
cotton produced by inserting

hirsutum





(Aventis
2mepsps gene into variety
L. (Cotton)




CropScience(AgrEvo))
Coker312 by Agrobacterium





under the control of





Ph4a748At and TPotpC


A-83
LLCotton25
Bayer
Glufosinate ammonium

Gossypium

WO2003013224,




CropScience
herbicide tolerant cotton

hirsutum

WO




(Aventis
produced by inserting a
L. (Cotton)
2007/017186




CropScience(AgrEvo))
modified phosphinothricin





acetyltransferase (PAT)





encoding gene from the soil





bacterium Streptomyces






hygroscopicus



A-84
LLCotton25 ×
Bayer
Stacked herbicide tolerant

Gossypium




MON15985
CropScience
and insect resistant cotton

hirsutum





(Aventis
combining tolerance to
L. (Cotton)




CropScience(AgrEvo))
glufosinate ammonium





herbicide from LLCotton25





(OECD identifier: ACS-





GHØØ1-3) with resistance to





insects from MON15985





(OECD identifier: MON-





15985-7)


A-85
MON15985
MONSANTO
Insect resistance

Gossypium

US 2004-




TECHNOLOGY
(Cry1Ac/Cry2Ab)

hirsutum

250317




LLC

L. (Cotton)


A-86
MON1445/1698
Monsanto
Glyphosate herbicide tolerant

Gossypium





Company
cotton produced by inserting

hirsutum






a naturally glyphosate
L. (Cotton)





tolerant form of the enzyme





5-enolpyruvyl shikimate-3-





phosphate synthase (EPSPS)





from A. tumefaciens strain





CP4.


A-87
MON15985 ×
Monsanto
Stacked insect resistant and

Gossypium




MON88913
Company
glyphosate tolerant cotton

hirsutum






produced by conventional
L. (Cotton)





cross-breeding of the parental





lines MON88913 (OECD





identifier: MON-88913-8)





and 15985 (OECD identifier:





MON-15985-7). Glyphosate





tolerance is derived from





MON88913 which contains





two genes encoding the





enzyme 5-





enolypyruvylshikimate-3-





phosphate synthase (EPSPS)





from the CP4 strain of






Agrobacterium tumefaciens.





Insect resistance is derived





MON15985 which was





produced by transformation





of the DP50B parent variety,





which contained event 531





(expressing Cry1Ac protein),





with purified plasmid DNA





containing the cry2Ab gene





from B. thuringiensis subsp.






kurstaki.


A-88
MON-
Monsanto
Stacked insect resistant and

Gossypium




15985-7 ×
Company
herbicide tolerant cotton

hirsutum




MON-

derived from conventional
L. (Cotton)



Ø1445-2

cross-breeding of the parental





lines 15985 (OECD





identifier: MON-15985-7)





and MON1445 (OECD





identifier: MON-Ø1445-2).


A-89
MON531/
Monsanto
Insect-resistant cotton

Gossypium




757/1076
Company
produced by inserting the

hirsutum






cry1Ac gene from Bacillus
L. (Cotton)






thuringiensis subsp. kurstaki





HD-73 (B.t.k.).


A-90
MON531/
Monsanto
Insect-resistant cotton

Gossypium




757/1076
Company
produced by inserting the

hirsutum






cry1Ac gene from Bacillus
L. (Cotton)






thuringiensis subsp. kurstaki





HD-73 (B.t.k.).


A-91
MON88913
Monsanto
Glyphosate herbicide tolerant

Gossypium

WO




Company
cotton produced by inserting

hirsutum

2004/072235





two genes encoding the
L. (Cotton)





enzyme 5-





enolypyruvylshikimate-3-





phosphate synthase (EPSPS)





from the CP4 strain of






Agrobacterium tumefaciens,;





WO 2004/072235


A-92
MON-
Monsanto
Stacked insect resistant and

Gossypium




ØØ531-6 ×
Company
herbicide tolerant cotton

hirsutum




MON-

derived from conventional
L. (Cotton)



Ø1445-2

cross-breeding of the parental





lines MON531 (OECD





identifier: MON-ØØ531-6)





and MON1445 (OECD





identifier: MON-Ø1445-2).


A-93
PV-
MONSANTO
Glyphosate tolerance

Gossypium

US 2004-



GHGT07
TECHNOLOGY


hirsutum

148666



(1445)
LLC

L. (Cotton)




BAYER




BIOSCIENCE




NV


A-94
T304-40

Insect-resistance (Cry1Ab)

Gossypium

WO2008/122406,







hirsutum

US2010077501






L. (Cotton)


A-95
T342-
SYNGENTA
Insect resistance (Cry1Ab)

Gossypium

WO



142
PARTICIPA-


hirsutum

2006/128568




TIONS AG

L. (Cotton)


A-96
LLcotton25
BAYER
Glufosinate resistance

Gossypium

WO




BIOSCIENCE


hirsutum

2003013224




N.V.

L. (Cotton)


A-97
X81359
BASF Inc.
Tolerance to imidazolinone

Helianthus






herbicides by selection of a

annuus (Sun-





naturally occurring mutant.
flower)


A-98
RH44
BASF Inc.
Selection for a mutagenized

Lens






version of the enzyme

culinaris (Len-





acetohydroxyacid synthase
til)





(AHAS), also known as





acetolactate synthase (ALS)





or acetolactate pyruvate-





lyase.


A-99
FP967
University of
A variant form of acetolactate

Linum





Saskatchewan,
synthase (ALS) was obtained

usitatissimum





Crop Dev.
from a chlorsulfuron tolerant
L. (Flax,




Centre
line of A. thaliana and used to
Linseed)





transform flax.


A-100
5345
Monsanto
Resistance to lepidopteran

Lycopersicon





Company
pests through the introduction

esculentum






of the cry1Ac gene from
(Tomato)






Bacillus thuringiensis subsp.






Kurstaki.


A-101
8338
Monsanto
Introduction of a gene

Lycopersicon





Company
sequence encoding the

esculentum






enzyme 1-amino-
(Tomato)





cyclopropane-1-carboxylic





acid deaminase (ACCd) that





metabolizes the precursor of





the fruit ripening hormone





ethylene.


A-102
1345-4
DNA Plant
Delayed ripening tomatoes

Lycopersicon





Technology
produced by inserting an

esculentum





Corporation
additional copy of a truncated
(Tomato)





gene encoding 1-





aminocyclopropane-1-





carboxyllic acid (ACC)





synthase, which resulted in





downregulation of the





endogenous ACC synthase





and reduced ethylene





accumulation.


A-103
35 1 N
Agritope Inc.
Introduction of a gene

Lycopersicon






sequence encoding the

esculentum






enzyme S-
(Tomato)





adenosylmethionine





hydrolase that metabolizes





the precursor of the fruit





ripening hormone ethylene


A-104
B, Da, F
Zeneca Seeds
Delayed softening tomatoes

Lycopersicon






produced by inserting a

esculentum






truncated version of the
(Tomato)





polygalacturonase (PG)





encoding gene in the sense or





anti-sense orientation in order





to reduce expression of the





endogenous PG gene, and





thus reduce pectin





degradation.


A-105
FLAVR
Calgene Inc.
Delayed softening tomatoes

Lycopersicon




SAVR

produced by inserting an

esculentum






additional copy of the
(Tomato)





polygalacturonase (PG)





encoding gene in the anti-





sense orientation in order to





reduce expression of the





endogenous PG gene and thus





reduce pectin degradation.


A-106
J101,
Monsanto
Glyphosate herbicide tolerant

Medicago




J163
Company
alfalfa (lucerne) produced by

sativa





and Forage
inserting a gene encoding the
(Alfalfa)




Genetics
enzyme 5-




International
enolypyruvylshikimate-3-





phosphate synthase (EPSPS)





from the CP4 strain of






Agrobacterium tumefaciens.


A-107
C/F/93/08-
Societe
Tolerance to the herbicides

Nicotiana




02
National
bromoxynil and ioxynil by

tabacum





d'Exploitation
incorporation of the nitrilase
L. (Tobacco)




des Tabacs
gene from Klebsiella




et Allumettes

pneumoniae.


A-108
Vector
Vector
Reduced nicotine content

Nicotiana




21-41
Tobacco Inc.
through introduction of a

tabacum






second copy of the tobacco
L. (Tobacco)





quinolinic acid





phosphoribosyltransferase





(QTPase) in the antisense





orientation. The NPTII





encoding gene from E. coli





was introduced as a selectable





marker to identify





transformants.


A-109
17053
MONSANTO
Glyphosate tolerance

Oryza

WO2010117737




TECHNOLOGY


sativa (Rice)




LLC


A-110
17314
MONSANTO
Glyphosate tolerance

Oryza

WO2010117735




TECHNOLOGY


sativa (Rice)




LLC


A-111
CL121,
BASF Inc.
Tolerance to the

Oryza




CL141,

imidazolinone herbicide,

sativa (Rice)



CFX51

imazethapyr, induced by





chemical mutagenesis of the





acetolactate synthase (ALS)





enzyme using ethyl





methanesulfonate (EMS).


A-112
GAT-
AVENTIS
Glufosinate tolerance

Oryza

WO



OS2
CROPSCIENCE,


sativa (Rice)
01/83818




N.V.


A-113
GAT-
BAYER
Glufosinate tolerance

Oryza

US 2008-



OS3
BIOSCIENCE


sativa (Rice)
289060




NV


A-114
IMINTA-1,
BASF Inc.
Tolerance to imidazolinone

Oryza




IMINTA-4

herbicides induced by

sativa (Rice)





chemical mutagenesis of the





acetolactate synthase (ALS)





enzyme using sodium azide.


A-115
LLRICE
Aventis
Glufosinate ammonium

Oryza




06,
CropScience
herbicide tolerant rice

sativa (Rice)



LLRICE

produced by inserting a



62

modified phosphinothricin





acetyltransferase (PAT)





encoding gene from the soil





bacterium Streptomyces






hygroscopicus).


A-116
LLRICE
Bayer
Glufosinate ammonium

Oryza




601
CropScience
herbicide tolerant rice

sativa (Rice)




(Aventis
produced by inserting a




CropScience(AgrEvo))
modified phosphinothricin





acetyltransferase (PAT)





encoding gene from the soil





bacterium Streptomyces






hygroscopicus).


A-117
PE-7
MAHARASHTRA
Insect resistance (Cry1Ac)

Oryza

WO




HYBRID


sativa (Rice)
2008/114282




SEEDS




COMPANY




LIMITED


A-118
PWC16
BASF Inc.
Tolerance to the

Oryza






imidazolinone herbicide,

sativa (Rice)





imazethapyr, induced by





chemical mutagenesis of the





acetolactate synthase (ALS)





enzyme using ethyl





methanesulfonate (EMS).


A-119
TT51
UNIV
Insect resistance

Oryza

CN1840655




ZHEJIANG
(Cry1Ab/Cry1Ac)

sativa (Rice)


A-120
Kefeng
CHINA NAT
Transgenic rice Kefeng 6 is a

Oryza

CN



No. 6
RICE RES
transformation event

sativa (Rice)
101824411




INST
containing two insect-





resistant genes, cry1Ac and





SCK (modified CpTI gene) in





China.


A-121
C5
United States
Plum pox virus (PPV)

Prunus





Department
resistant plum tree produced

domestica





of
through Agrobacterium-
(Plum)




Agriculture -
mediated transformation with




Agricultural
a coat protein (CP) gene from




Research
the virus.




Service


A-122
ATBT04-6,
Monsanto
Colorado potato beetle

Solanum




ATBT04-27,
Company
resistant potatoes produced

tuberosum




ATBT04-30,

by inserting the cry3A gene
L. (Potato)



ATBT04-31,

from Bacillus thuringiensis



ATBT04-36,

(subsp. Tenebrionis).



SPBT02-5,



SPBT02-7


A-123
BT6,
Monsanto
Colorado potato beetle

Solanum




BT10,
Company
resistant potatoes produced

tuberosum




BT12,

by inserting the cry3A gene
L. (Potato)



BT16,

from Bacillus thuringiensis



BT17,

(subsp. Tenebrionis).



BT18,



BT23


A-124
RBMT15-101,
Monsanto
Colorado potato beetle and

Solanum




SEMT15-02,
Company
potato virus Y (PVY)

tuberosum




SEMT15-15

resistant potatoes produced
L. (Potato)





by inserting the cry3A gene





from Bacillus thuringiensis





(subsp. Tenebrionis) and the





coat protein encoding gene





from PVY.


A-125
RBMT21-129,
Monsanto
Colorado potato beetle and

Solanum




RBMT21-350,
Company
potato leafroll virus (PLRV)

tuberosum




RBMT22-082

resistant potatoes produced
L. (Potato)





by inserting the cry3A gene





from Bacillus thuringiensis





(subsp. Tenebrionis) and the





replicase encoding gene from





PLRV.


A-126
EH92-527
BASF Plant
Crop composition; Amflora;

Solanum





Science
Unique EU identifier: BPS-

tuberosum






25271-9
L. (Potato)


A-127
AP205C
BASF Inc.
Selection for a mutagenized

Triticum




L

version of the enzyme

aestivum






acetohydroxyacid synthase
(Wheat)





(AHAS), also known as





acetolactate synthase (ALS)





or acetolactate pyruvate-





lyase.


A-128
AP602C
BASF Inc.
Selection for a mutagenized

Triticum




L

version of the enzyme

aestivum






acetohydroxyacid synthase
(Wheat)





(AHAS), also known as





acetolactate synthase (ALS)





or acetolactate pyruvate-





lyase.


A-129
BW255-2,
BASF Inc.
Selection for a mutagenized

Triticum




BW238-3

version of the enzyme

aestivum






acetohydroxyacid synthase
(Wheat)





(AHAS), also known as





acetolactate synthase (ALS)





or acetolactate pyruvate-





lyase.


A-130
BW7
BASF Inc.
Tolerance to imidazolinone

Triticum






herbicides induced by

aestivum






chemical mutagenesis of the
(Wheat)





acetohydroxyacid synthase





(AHAS) gene using sodium





azide.


A-131
Event 1
SYNGENTA

Fusarium resistance

Triticum

CA 2561992




PARTICIPA-
(trichothecene 3-O-

aestivum





TIONS AG
acetyltransferase)
(Wheat)


A-132
JOPLIN1
SYNGENTA
disease (fungal) resistance

Triticum

WO; US




PARTICIPA-
(trichothecene 3-O-

aestivum

2008064032




TIONS AG
acetyltransferase)
(Wheat)


A-133
MON71800
Monsanto
Glyphosate tolerant wheat

Triticum





Company
variety produced by inserting

aestivum






a modified 5-
(Wheat)





enolpyruvylshikimate-3-





phosphate synthase (EPSPS)





encoding gene from the soil





bacterium Agrobacterium






tumefaciens, strain CP4.


A-134
SWP965001
Cyanamid
Selection for a mutagenized

Triticum





Crop
version of the enzyme

aestivum





Protection
acetohydroxyacid synthase
(Wheat)





(AHAS), also known as





acetolactate synthase (ALS)





or acetolactate pyruvate-





lyase.


A-135
Teal 11A
BASF Inc.
Selection for a mutagenized

Triticum






version of the enzyme

aestivum






acetohydroxyacid synthase
(Wheat)





(AHAS), also known as





acetolactate synthase (ALS)





or acetolactate pyruvate-





lyase.


A-136
176
Syngenta
Insect-resistant maize

Zea mays





Seeds, Inc.
produced by inserting the
L. (Maize)





cry1Ab gene from Bacillus






thuringiensis subsp. kurstaki.





The genetic modification





affords resistance to attack by





the European corn borer





(ECB).


A-137
3272
SYNGENTA
Self processing corn (alpha-

Zea mays

US 2006-




PARTICIPA-
amylase)
L. (Maize)
230473,




TIONS AG


US2010063265


A-138
5307
SYNGENTA
Insect (corn rootworm)

Zea mays

WO2010077816




PARTICIPA-
resistance (FR8a)
L. (Maize)




TIONS AG


A-139
3751IR
Pioneer Hi-
Selection of somaclonal

Zea mays





Bred
variants by culture of
L. (Maize)




International
embryos on imidazolinone




Inc.
containing media.


A-140
676, 678,
Pioneer Hi-
Male-sterile and glufosinate

Zea mays




680
Bred
ammonium herbicide tolerant
L. (Maize)




International
maize produced by inserting




Inc.
genes encoding DNA adenine





methylase and





phosphinothricin





acetyltransferase (PAT) from






Escherichia coli and






Streptomyces







viridochromogenes,





respectively.


A-141
ACS-
Bayer
Stacked insect resistant and

Zea mays




ZMØØ3-
CropScience
herbicide tolerant corn hybrid
L. (Maize)



2 ×
(Aventis
derived from conventional



MON-
CropScience(AgrEvo))
cross-breeding of the parental



ØØ81Ø-

lines T25 (OECD identifier:



6

ACS-ZMØØ3-2) and





MON810 (OECD





identifier: MON-ØØ81Ø-6).


A-142
B16
DEKALB
Glufosinate resistance

Zea mays

US 2003-




GENETICS

L. (Maize)
126634




CORP


A-143
B16
Dekalb
Glufosinate ammonium

Zea mays




(DLL25)
Genetics
herbicide tolerant maize
L. (Maize)




Corporation
produced by inserting the





gene encoding





phosphinothricin





acetyltransferase (PAT) from






Streptomyces hygroscopicus.


A-144
BT11
Syngenta
Insect-resistant and herbicide

Zea mays

WO



(X4334C
Seeds, Inc.
tolerant maize produced by
L. (Maize)
2010148268



BR,

inserting the cry1Ab gene



X4734C

from Bacillus thuringiensis



BR)

subsp. kurstaki, and the





phosphinothricin N-





acetyltransferase (PAT)





encoding gene from S.






viridochromogenes.


A-145
BT11 ×
Syngenta
Stacked insect resistant and

Zea mays




GA21
Seeds, Inc.
herbicide tolerant maize
L. (Maize)





produced by conventional





cross breeding of parental





lines BT11 (OECD unique





identifier: SYN-BTØ11-1)





and GA21 (OECD unique





identifier: MON-ØØØ21-9).


A-146
BT11 ×
Syngenta
Stacked insect resistant and

Zea mays




MIR162
Seeds, Inc.
herbicide tolerant maize
L. (Maize)





produced by conventional





cross breeding of parental





lines BT11 (OECD unique





identifier: SYN-BTØ11-1)





and MIR162 (OECD unique





identifier: SYN-IR162-4).





Resistance to the European





Corn Borer and tolerance to





the herbicide glufosinate





ammonium (Liberty) is





derived from BT11, which





contains the cry1Ab gene





from Bacillus thuringiensis





subsp. kurstaki, and the





phosphinothricin N-





acetyltransferase (PAT)





encoding gene from S.






viridochromogenes.





Resistance to other





lepidopteran pests, including






H. zea, S. frugiperda, A.







ipsilon, and S. albicosta, is





derived from MIR162, which





contains the vip3Aa gene





from Bacillus thuringiensis





strain AB88.


A-147
BT11 ×
Syngenta

Bacillus thuringiensis


Zea mays




MIR162 ×
Seeds, Inc.
Cry1Ab delta-endotoxin
L. (Maize)



MIR604

protein and the genetic





material necessary for its





production (via elements of





vector pZO1502) in Event





Bt11 corn (OECD Unique





Identifier: SYN-BTØ11-1) ×






Bacillus thuringiensis






Vip3Aa20 insecticidal protein





and the genetic material





necessary for its production





(via elements of vector





pNOV1300) in Event





MIR162 maize (OECD





Unique Identifier: SYN-





IR162-4) × modified Cry3A





protein and the genetic





material necessary for its





production (via elements of





vector pZM26) in Event





MIR604 corn (OECD Unique





Identifier: SYN-IR6Ø4-5).


A-148
BT11 ×
Syngenta
Stacked insect resistant and

Zea mays




MIR604
Seeds, Inc.
herbicide tolerant maize
L. (Maize)





produced by conventional





cross breeding of parental





lines BT11 (OECD unique





identifier: SYN-BTØ11-1)





and MIR604 (OECD unique





identifier: SYN-IR6Ø5-5).





Resistance to the European





Corn Borer and tolerance to





the herbicide glufosinate





ammonium (Liberty) is





derived from BT11, which





contains the cry1Ab gene





from Bacillus thuringiensis





subsp. kurstaki, and the





phosphinothricin N-





acetyltransferase (PAT)





encoding gene from S.






viridochromogenes. Corn





rootworm-resistance is





derived from MIR604 which





contains the mcry3A gene





from Bacillus thuringiensis.


A-149
BT11 ×
Syngenta
Stacked insect resistant and

Zea mays




MIR604 ×
Seeds, Inc.
herbicide tolerant maize
L. (Maize)



GA21

produced by conventional





cross breeding of parental





lines BT11 (OECD unique





identifier: SYN-BTØ11-1),





MIR604 (OECD unique





identifier: SYN-IR6Ø5-5) and





GA21 (OECD unique





identifier: MON-ØØØ21-9).





Resistance to the European





Corn Borer and tolerance to





the herbicide glufosinate





ammonium (Liberty) is





derived from BT11, which





contains the cry1Ab gene





from Bacillus thuringiensis





subsp. kurstaki, and the





phosphinothricin N-





acetyltransferase (PAT)





encoding gene from S.






viridochromogenes. Corn





rootworm-resistance is





derived from MIR604 which





contains the mcry3A gene





from Bacillus thuringiensis.





Tolerance to glyphosate





herbcicide is derived from





GA21 which contains a a





modified EPSPS gene from





maize.


A-150
CBH-351
Aventis
Insect-resistant and

Zea mays





Crop Science
glufosinate ammonium
L. (Maize)





herbicide tolerant maize





developed by inserting genes





encoding Cry9C protein from






Bacillus thuringiensis subsp






tolworthi and





phosphinothricin





acetyltransferase (PAT) from






Streptomyces hygroscopicus.


A-151
DAS-
DOW
Lepidopteran insect resistant

Zea mays




06275-8
AgroSciences
and glufosinate ammonium
L. (Maize)




LLC
herbicide-tolerant maize





variety produced by inserting





the cry1F gene from Bacillus






thuringiensis var aizawai and





the phosphinothricin





acetyltransferase (PAT) from






Streptomyces hygroscopicus.


A-152
DAS-
DOW
Corn rootworm-resistant

Zea mays

US 2006-



59122-7
AgroSciences
maize produced by inserting
L. (Maize)
070139, US




LLC and
the cry34Ab1 and cry35Ab1

2011030086




Pioneer Hi-
genes from Bacillus




Bred

thuringiensis strain PS149B1.




International
The PAT encoding gene from




Inc.

Streptomyces







viridochromogenes was





introduced as a selectable





marker


A-153
DAS-
DOW
Stacked insect resistant and

Zea mays




59122-7 ×
AgroSciences
herbicide tolerant maize
L. (Maize)



NK603
LLC and
produced by conventional




Pioneer Hi-
cross breeding of parental




Bred
lines DAS-59122-7 (OECD




International
unique identifier: DAS-




Inc.
59122-7) with NK603





(OECD unique identifier:





MON-ØØ6Ø3-6). Corn





rootworm-resistance is





derived from DAS-59122-7





which contains the cry34Ab1





and cry35Ab1 genes from






Bacillus thuringiensis strain





PS149B1. Tolerance to





glyphosate herbcicide is





derived from NK603.


A-154
DAS-
DOW
Stacked insect resistant and

Zea mays




59122-7 ×
AgroSciences
herbicide tolerant maize
L. (Maize)



TC1507 ×
LLC and
produced by conventional



NK603
Pioneer Hi-
cross breeding of parental




Bred
lines DAS-59122-7 (OECD




International
unique identifier: DAS-




Inc.
59122-7) and TC1507





(OECD unique identifier:





DAS-Ø15Ø7-1) with NK603





(OECD unique identifier:





MON-ØØ6Ø3-6). Corn





rootworm-resistance is





derived from DAS-59122-7





which contains the cry34Ab1





and cry35Ab1 genes from






Bacillus thuringiensis strain





PS149B1. Lepidopteran





resistance and toleraance to





glufosinate ammonium





herbicide is derived from





TC1507. Tolerance to





glyphosate herbcicide is





derived from NK603.


A-155
DAS-
DOW
Stacked insect resistant and

Zea mays




Ø15Ø7-1 ×
AgroSciences
herbicide tolerant corn hybrid
L. (Maize)



MON-
LLC
derived from conventional



ØØ6Ø3-

cross-breeding of the parental



6

lines 1507 (OECD identifier:





DAS-Ø15Ø7-1) and NK603





(OECD identifier: MON-





ØØ6Ø3-6).


A-156
DBT418
Dekalb
Insect-resistant and

Zea mays





Genetics
glufosinate ammonium
L. (Maize)




Corporation
herbicide tolerant maize





developed by inserting genes





encoding Cry1AC protein





from Bacillus thuringiensis





subsp kurstaki and





phosphinothricin





acetyltransferase (PAT) from






Streptomyces hygroscopicus



A-157
DK404S
BASF Inc.
Somaclonal variants with a

Zea mays




R

modified acetyl-CoA-
L. (Maize)





carboxylase (ACCase) were





selected by culture of





embryos on sethoxydim





enriched medium.


A-158
DP-098140-6
PIONEER
Glyphosate tolerance/ALS

Zea mays

WO




HI-BRED
inhibitor tolerance
L. (Maize)
2008/112019,




INTERNA-


US2010240059




TIONAL


A-159
DP-Ø9814Ø-
Pioneer Hi-
Corn line 98140 was

Zea mays




6 (Event
Bred
genetically engineered to
L. (Maize)



98140)
International
express the GAT4621




Inc.
(glyphosate acetyltransferase)





and ZM-HRA (modified





version of a maize





acetolactate synthase)





proteins. The GAT4621





protein, encoded by the





gat4621 gene, confers





tolerance to glyphosate-





containing herbicides by





acetylating glyphosate and





thereby rendering it non-





phytotoxic. The ZM-HRA





protein, encoded by the zm-





hra gene, confers tolerance to





the ALS-inhibiting class of





herbicides.


A-160
Event
Syngenta
Maize line expressing a heat

Zea mays




3272
Seeds, Inc.
stable alpha-amylase gene
L. (Maize)





amy797E for use in the dry-





grind ethanol process. The





phosphomannose isomerase





gene from E. coli was used as





a selectable marker.


A-161
Event
Pioneer Hi-
Maize event expressing

Zea mays




98140
Bred
tolerance to glyphosate
L. (Maize)




International
herbicide, via expression of a




Inc.
modified bacterial glyphosate





N-acetlytransferase, and





ALS-inhibiting herbicides,





vial expression of a modified





form of the maize acetolactate





synthase enzyme.


A-162
EXP1910
Syngenta
Tolerance to the

Zea mays




IT
Seeds, Inc.
imidazolinone herbicide,
L. (Maize)




(formerly
imazethapyr, induced by




Zeneca
chemical mutagenesis of the




Seeds)
acetolactate synthase (ALS)





enzyme using ethyl





methanesulfonate (EMS).


A-163
FI117
DEKALB
Glyphosate resistance

Zea mays

U.S. Pat. No.




GENETICS

L. (Maize)
6,040,497




CORP


A-164
GA21
Monsanto
Introduction, by particle

Zea mays

U.S. Pat. No.




Company
bombardment, of a modified
L. (Maize)
6,040,497





5-enolpyruvyl shikimate-3-





phosphate synthase (EPSPS),





an enzyme involved in the





shikimate biochemical





pathway for the production of





the aromatic amino acids


A-165
GA21 ×
Monsanto
Stacked insect resistant and

Zea mays




MON810
Company
herbicide tolerant corn hybrid
L. (Maize)





derived from conventional





cross-breeding of the parental





lines GA21 (OECD





identifider: MON-ØØØ21-9)





and MON810 (OECD





identifier: MON-ØØ81Ø-6).


A-166
GAT-
BAYER
Glufosinate tolerance

Zea mays

WO



ZM1
CROPSCIENCE

L. (Maize)
01/51654




N.V.


A-167
GG25
DEKALB
Glyphosate resistance

Zea mays

U.S. Pat. No.




GENETICS

L. (Maize)
6,040,497




CORP


A-168
GJ11
DEKALB
Glyphosate resistance

Zea mays

U.S. Pat. No.




GENETICS

L. (Maize)
6,040,497




CORP


A-169
IT
Pioneer Hi-
Tolerance to the

Zea mays





Bred
imidazolinone herbicide,
L. (Maize)




International
imazethapyr, was obtained by




Inc.
in vitro selection of





somaclonal variants.


A-170
LY038
Monsanto
Altered amino acid

Zea mays

U.S. Pat. No.




Company
composition, specifically
L. (Maize)
7,157,281,





elevated levels of lysine,

US2010212051,





through the introduction of

US





the cordapA gene, derived

2007028322





from Corynebacterium






glutamicum, encoding the





enzyme dihydrodipicolinate





synthase (cDHDPS)


A-171
MIR162
SYNGENTA
Insect resistance

Zea mays

WO




PARTICIPA-

L. (Maize)
2007142840




TIONS AG


A-172
MIR604
Syngenta
Corn rootworm resistant

Zea mays

EP 1 737 290




Seeds, Inc.
maize produced by
L. (Maize)





transformation with a





modified cry3A gene. The





phosphomannose isomerase





gene from E. coli was used as





a selectable marker;





(Cry3a055)


A-173
MIR604 ×
Syngenta
Stacked insect resistant and

Zea mays




GA21
Seeds, Inc.
herbicide tolerant maize
L. (Maize)





produced by conventional





cross breeding of parental





lines MIR604 (OECD unique





identifier: SYN-IR6Ø5-5) and





GA21 (OECD unique





identifier: MON-ØØØ21-9).





Corn rootworm-resistance is





derived from MIR604 which





contains the mcry3A gene





from Bacillus thuringiensis.





Tolerance to glyphosate





herbcicide is derived from





GA21.


A-174
MON80100
Monsanto
Insect-resistant maize

Zea mays





Company
produced by inserting the
L. (Maize)





cry1Ab gene from Bacillus






thuringiensis subsp. kurstaki.





The genetic modification





affords resistance to attack by





the European corn borer





(ECB).


A-175
MON802
Monsanto
Insect-resistant and

Zea mays





Company
glyphosate herbicide tolerant
L. (Maize)





maize produced by inserting





the genes encoding the





Cry1Ab protein from Bacillus






thuringiensis and the 5-





enolpyruvylshikimate-3-





phosphate synthase (EPSPS)





from A. tumefaciens strain





CP4.


A-176
MON809
Pioneer Hi-
Resistance to European corn

Zea mays





Bred
borer (Ostrinia nubilalis) by
L. (Maize)




International
introduction of a synthetic




Inc.
cry1Ab gene. Glyphosate





resistance via introduction of





the bacterial version of a





plant enzyme, 5-enolpyruvyl





shikimate-3-phosphate





synthase (EPSPS).


A-177
MON810
Monsanto
Insect-resistant maize

Zea mays

US 2004-




Company
produced by inserting a
L. (Maize)
180373





truncated form of the cry1Ab





gene from Bacillus






thuringiensis subsp. kurstaki





HD-1. The genetic





modification affords





resistance to attack by the





European corn borer (ECB)


A-178
MON810 ×
Monsanto
Stacked insect resistant and

Zea mays




MON88017
Company
glyphosate tolerant maize
L. (Maize)





derived from conventional





cross-breeding of the parental





lines MON810 (OECD





identifier: MON-ØØ81Ø-6)





and MON88017 (OECD





identifier: MON-88Ø17-3).





European corn borer (ECB)





resistance is derived from a





truncated form of the cry1Ab





gene from Bacillus






thuringiensis subsp. kurstaki





HD-1 present in MON810.





Corn rootworm resistance is





derived from the cry3Bb1





gene from Bacillus






thuringiensis subspecies






kumamotoensis strain





EG4691 present in





MON88017. Glyphosate





tolerance is derived from a 5-





enolpyruvylshikimate-3-





phosphate synthase (EPSPS)





encoding gene from






Agrobacterium tumefaciens






strain CP4 present in





MON88017.


A-179
MON832
Monsanto
Introduction, by particle

Zea mays





Company
bombardment, of glyphosate
L. (Maize)





oxidase (GOX) and a





modified 5-enolpyruvyl





shikimate-3-phosphate





synthase (EPSPS), an enzyme





involved in the shikimate





biochemical pathway for the





production of the aromatic





amino acids.


A-180
MON863
Monsanto
Corn root worm resistant

Zea mays





Company
maize produced by inserting
L. (Maize)





the cry3Bb1 gene from






Bacillus thuringiensis subsp.






kumamotoensis.


A-181
MON863 ×
Monsanto
Stacked insect resistant corn

Zea mays




MON810
Company
hybrid derived from
L. (Maize)





conventional cross-breeding





of the parental lines MON863





(OECD identifier: MON-





ØØ863-5) and MON810





(OECD identifier: MON-





ØØ81Ø-6)


A-182
MON863 ×
Monsanto
Stacked insect resistant and

Zea mays




MON810 ×
Company
herbicide tolerant corn hybrid
L. (Maize)



NK603

derived from conventional





cross-breeding of the stacked





hybrid MON-ØØ863-5 ×





MON-ØØ81Ø-6 and NK603





(OECD identifier: MON-





ØØ6Ø3-6).


A-183
MON863 ×
Monsanto
Stacked insect resistant and

Zea mays




NK603
Company
herbicide tolerant corn hybrid
L. (Maize)





derived from conventional





cross-breeding of the parental





lines MON863 (OECD





identifier: MON-ØØ863-5)





and NK603 (OECD





identifier: MON-ØØ6Ø3-6).


A-184
MON87460
Monsanto
Drought tolerance; Water

Zea mays

WO




Company
deficit tolerance
L. (Maize)
2009111263


A-185
MON88017
Monsanto
Corn rootworm-resistant

Zea mays

WO2005059103




Company
maize produced by inserting
L. (Maize)





the cry3Bb1 gene from






Bacillus thuringiensis






subspecies kumamotoensis





strain EG4691. Glyphosate





tolerance derived by inserting





a 5-enolpyruvylshikimate-3-





phosphate synthase (EPSPS)





encoding gene from






Agrobacterium tumefaciens






strain CP4


A-186
MON89034
Monsanto
Maize event expressing two

Zea mays

WO




Company
different insecticidal proteins
L. (Maize)
2007140256





from Bacillus thuringiensis





providing resistance to





number of lepidopteran pests;





nsect resistance (Lepidoptera-





Cry1A.105- Cry2Ab)


A-187
MON89034 ×
Monsanto
Stacked insect resistant and

Zea mays




MON88017
Company
glyphosate tolerant maize
L. (Maize)





derived from conventional





cross-breeding of the parental





lines MON89034 (OECD





identifier: MON-89Ø34-3)





and MON88017 (OECD





identifier: MON-88Ø17-3).





Resistance to Lepiopteran





insects is derived from two





crygenes present in





MON89043. Corn rootworm





resistance is derived from a





single cry genes and





glyphosate tolerance is





derived from the 5-





enolpyruvylshikimate-3-





phosphate synthase (EPSPS)





encoding gene from






Agrobacterium tumefaciens






present in MON88017.


A-188
MON89034 ×
Monsanto
Stacked insect resistant and

Zea mays




NK603
Company
herbicide tolerant maize
L. (Maize)





produced by conventional





cross breeding of parental





lines MON89034 (OECD





identifier: MON-89Ø34-3)





with NK603 (OECD unique





identifier: MON-ØØ6Ø3-6).





Resistance to Lepiopteran





insects is derived from two





crygenes present in





MON89043. Tolerance to





glyphosate herbcicide is





derived from NK603.


A-189
MON89034 ×
Monsanto
Stacked insect resistant and

Zea mays




TC1507 ×
Company
herbicide tolerant maize
L. (Maize)



MON88017 ×

produced by conventional



DAS-

cross breeding of parental



59122-7

lines: MON89034, TC1507,





MON88017, and DAS-





59122. Resistance to the





above-ground and below-





ground insect pests and





tolerance to glyphosate and





glufosinate-ammonium





containing herbicides.


A-190
MON-
Monsanto
Stacked insect resistant and

Zea mays




ØØ6Ø3-
Company
herbicide tolerant corn hybrid
L. (Maize)



6 ×

derived from conventional



MON-

cross-breeding of the parental



ØØ81Ø-

lines NK603 (OECD



6

identifier: MON-ØØ6Ø3-6)





and MON810 (OECD





identifier: MON-ØØ81Ø-6).


A-191
MON-
Monsanto
Stacked insect resistant and

Zea mays




ØØ81Ø-
Company
enhanced lysine content
L. (Maize)



6 ×

maize derived from



LY038

conventional cross-breeding





of the parental lines MON810





(OECD identifier: MON-





ØØ81Ø-6) and LY038





(OECD identifier: REN-





ØØØ38-3).


A-192
MON-
Monsanto
Stacked insect resistant and

Zea mays




ØØ863-5 ×
Company
herbicide tolerant corn hybrid
L. (Maize)



MON-

derived from conventional



ØØ6Ø3-

cross-breeding of the parental



6

lines MON863 (OECD





identifier: MON-ØØ863-5)





and NK603 (OECD





identifier: MON-ØØ6Ø3-6).


A-193
MON-
Monsanto
Stacked insect resistant corn

Zea mays




ØØ863-5 ×
Company
hybrid derived from
L. (Maize)



MON-

conventional cross-breeding



ØØ81Ø-

of the parental lines MON863



6

(OECD identifier: MON-





ØØ863-5) and MON810





(OECD identifier: MON-





ØØ81Ø-6)


A-194
MON-
Monsanto
Stacked insect resistant and

Zea mays




ØØ863-5 ×
Company
herbicide tolerant corn hybrid
L. (Maize)



MON-

derived from conventional



ØØ81Ø-

cross-breeding of the stacked



6 ×

hybrid MON-ØØ863-5 ×



MON-

MON-ØØ81Ø-6 and NK603



ØØ6Ø3-

(OECD identifier: MON-



6

ØØ6Ø3-6).


A-195
MON-
Monsanto
Stacked insect resistant and

Zea mays




ØØØ21-
Company
herbicide tolerant corn hybrid
L. (Maize)



9 ×

derived from conventional



MON-

cross-breeding of the parental



ØØ81Ø-

lines GA21 (OECD



6

identifider: MON-ØØØ21-9)





and MON810 (OECD





identifier: MON-ØØ81Ø-6).


A-196
MS3
Bayer
Male sterility caused by

Zea mays





CropScience
expression of the barnase
L. (Maize)




(Aventis
ribonuclease gene from




CropScience(AgrEvo))

Bacillus amyloliquefaciens;





PPT resistance was via PPT-





acetyltransferase (PAT).


A-197
MS6
Bayer
Male sterility caused by

Zea mays





CropScience
expression of the barnase
L. (Maize)




(Aventis
ribonuclease gene from




CropScience(AgrEvo))

Bacillus amyloliquefaciens;





PPT resistance was via PPT-





acetyltransferase (PAT).


A-198
NK603
Monsanto
Introduction, by particle

Zea mays





Company
bombardment, of a modified
L. (Maize)





5-enolpyruvyl shikimate-3-





phosphate synthase (EPSPS),





an enzyme involved in the





shikimate biochemical





pathway for the production of





the aromatic amino acids.


A-199
NK603 ×
Monsanto
Stacked insect resistant and

Zea mays




MON810
Company
herbicide tolerant corn hybrid
L. (Maize)





derived from conventional





cross-breeding of the parental





lines NK603 (OECD





identifier: MON-ØØ6Ø3-6)





and MON810 (OECD





identifier: MON-ØØ81Ø-6).


A-200
NK603 ×
Monsanto
Stacked glufosinate

Zea mays




T25
Company
ammonium and glyphosate
L. (Maize)





herbicide tolerant maize





hybrid derived from





conventional cross-breeding





of the parental lines NK603





(OECD identifier: MON-





ØØ6Ø3-6) and T25 (OECD





identifier: ACS-ZM003-2).


A-201
PV-
MONSANTO
Glyphosate tolerance

Zea mays

US 2007-



ZMGT32
TECHNOLOGY

L. (Maize)
056056



(NK603)
LLC


A-202
PV-
MONSANTO
Glyphosate tolerance

Zea mays

US



ZMGT32
TECHNOLOGY

L. (Maize)
2007292854



(nk603)
LLC


A-203
PV-
MONSANTO
Insect resistance (Cry3Bb)

Zea mays

US 2006-



ZMIR13
TECHNOLOGY

L. (Maize)
095986



(MON863)
LLC


A-204
SYN-
Syngenta
Stacked insect resistant and

Zea mays




BTØ11-1 ×
Seeds, Inc.
herbicide tolerant maize
L. (Maize)



MON-

produced by conventional



ØØØ21-

cross breeding of parental



9

lines BT11 (OECD unique





identifier: SYN-BTØ11-1)





and GA21 (OECD unique





identifier: MON-ØØØ21-9).


A-205
T14
Bayer
Glufosinate herbicide tolerant

Zea mays





CropScience
maize produced by inserting
L. (Maize)




(Aventis
the phosphinothricin N-




CropScience(AgrEvo))
acetyltransferase (PAT)





encoding gene from the





aerobic actinomycete






Streptomyces







viridochromogenes.


A-206
T14, T25
Bayer
Glufosinate herbicide tolerant

Zea mays





CropScience
maize produced by inserting
L. (Maize)




(Aventis
the phosphinothricin N-




CropScience(AgrEvo))
acetyltransferase (PAT)





encoding gene from the





aerobic actinomycete






Streptomyces







viridochromogenes.


A-207
T25 ×
Bayer
Stacked insect resistant and

Zea mays




MON810
CropScience
herbicide tolerant corn hybrid
L. (Maize)




(Aventis
derived from conventional




CropScience(AgrEvo))
cross-breeding of the parental





lines T25 (OECD identifier:





ACS-ZMØØ3-2) and





MON810 (OECD





identifier: MON-ØØ81Ø-6).


A-208
TC1507
Mycogen
Insect-resistant and

Zea mays

U.S. Pat. No.




(c/o Dow
glufosinate ammonium
L. (Maize)
7,435,807




AgroSciences);
herbicide tolerant maize




Pioneer
produced by inserting the




(c/o Dupont)
cry1F gene from Bacillus






thuringiensis var. aizawai and





the phosphinothricin N-





acetyltransferase encoding





gene from Streptomyces






viridochromogenes; Insect





resistance (Cry1F)


A-209
TC1507 ×
DOW
Stacked insect resistant and

Zea mays




DAS-
AgroSciences
herbicide tolerant maize
L. (Maize)



59122-7
LLC and
produced by conventional




Pioneer Hi-
cross breeding of parental




Bred
lines TC1507 (OECD unique




International
identifier: DAS-Ø15Ø7-1)




Inc.
with DAS-59122-7 (OECD





unique identifier: DAS-





59122-7). Resistance to





lepidopteran insects is





derived from TC1507 due the





presence of the cry1F gene





from Bacillus thuringiensis





var. aizawai. Corn rootworm-





resistance is derived from





DAS-59122-7 which contains





the cry34Ab1 and cry35Ab1





genes from Bacillus






thuringiensis strain PS149B1.





Tolerance to glufosinate





ammonium herbcicide is





derived from TC1507 from





the phosphinothricin N-





acetyltransferase encoding





gene from Streptomyces






viridochromogenes.


A-210
VIP1034
SYNGENTA
Insect resistance

Zea mays

WO




PARTICIPA-

L. (Maize)
03/052073




TIONS AG


A-211
E6611.32.1.38/
Pioneer Hi-
1) MS45: anther-specific

zea mays

WO



DP-32138-1/
Bred
5126 (Zea mays) promoter >
L. (Maize)
2009103049,



32138
International
fertility restoration Ms45

MX




Inc.
(Zea mays) coding sequence >

2010008977





fertility restoration Ms45





(Zea mays) 3′-untranslated





region 2) ZM-AA1:





polygalacturonase 47 (Zea






mays) promoter > brittle-1





(Zea mays) chloroplast transit





peptide > alpha-amylase-1





(Zea mays) truncated coding





sequence > >In2-1 (Zea






mays) 3′-untranslated region





3) DSRED2: 35S





(Cauliflower Mosaic Virus)





enhancer > lipid transfer





protein-2 (Hordeum vulgare)





promoter > red fluorescent





protein (Dicosoma sp.)





variant coding sequence >





protein inhibitor II (Solanum






tuberosum) 3′-untranslated





region


A-212
DAS-
DOW
RB7 MARv3>zmUbiquitin 1

Zea mays

WO 2011022469



40278-9
AgroSciences
promoter>aad1>zmPER5
L. (Maize)




LLC
3′UTR>RB 7 MARv4. The





aad-1 gene confers tolerance





to 2,4- dichlorophenoxyacetic





acid and





aryloxyphenoxypropionate





(commonly referred to as





“fop” herbicides such as





quizalofop) herbicides


A-213
MIR604
Syngenta
1) CRY3A: metallotionin-like

Zea mays

US




Participations
gene (Zea mays) promoter >
L. (Maize)
2005216970,




AG
delta-endotoxin cry3a

US





(Bacillus thuringiensis subsp.

2008167456,






tenebrionis) coding

US





sequence, modified to include

2011111420





a cathepsin-G protease





recognition site and maize





codon optimized > nopaline





synthase (Agrobacterium






tumefaciens) 3′-untranslated





region 2) PMI: polyubiquitin





(Zea mays) promoter (incl.





first intron) > mannose-6-





phosphate isomerase





(Escherichia coli) coding





sequence > nopaline synthase





(Agrobacterium tumefaciens)





3′-untranslated region


A-214
MON87427
MONSANTO
The transgene insert and

Zea mays

WO




TECHNOLOGY
expression cassette of
L. (Maize)
2011062904




LLC
MON87427 comprises the





promoter and leader from the





cauliflower mosaic virus





(CaMV) 35 S containing a





duplicated enhancer region





(P-e35S); operably linked to a





DNA leader derived from the





first intron from the maize





heat shock protein 70 gene (I-





HSP70); operably linked to a





DNA molecule encoding an





N-terminal chloroplast transit





peptide from the shkG gene





from Arabidopsis thaliana





EPSPS (Ts-CTP2); operably





linked to a DNA molecule





derived from the aroA gene





from the Agrobacterium sp.





strain CP4 and encoding the





CP4 EPSPS protein; operably





linked to a 3′ UTR DNA





molecule derived from the





nopaline synthase (T-NOS)





gene from Agrobacterium






tumefaciens.


A-215
DP-004114-3
Pioneer Hi-
cry1F, cry34Ab1, cry35Ab1,

Zea mays

US 2011154523




Bred
and pat: resistance to certain
L. (Maize)




International
lepidopteran and coleopteran




Inc.
pests, as well as tolerance to





phosphinothricin.


A-216
DP-032316-8
Pioneer Hi-
Cry1F, cry34Ab1, cry35Ab1,

Zea mays

US 2011154524




Bred
pat: resistance to certain
L. (Maize)




International
lepidopteran and coleopteran




Inc.
pests, as well as tolerance to





phosphinothricin


A-217
DP-040416-8
Pioneer Hi-
Cry1F, cry34Ab1, cry35Ab1,

Zea mays

US



a
Bred
pat: resistance to certain
L. (Maize)
20110154525




International
lepidopteran and coleopteran




Inc.
pests, as well as tolerance to





phosphinothricin


A-218
DP-043A47-3
Pioneer Hi-
Cry1F, cry34Ab1, cry35Ab1,

Zea mays

US20110154526




Bred
pat: resistance to certain
L. (Maize)




International
lepidopteran and coleopteran




Inc.
pests, as well as tolerance to





phosphinothricin









Particularly useful transgenic plants which may be treated according to the invention are plants containing transformation events, or a combination of transformation events, and that are listed for example in the databases for various national or regional regulatory agencies including Event 1143-14A (cotton, insect control, not deposited, described in WO2006/128569); Event 1143-51B (cotton, insect control, not deposited, described in WO2006/128570); Event 1445 (cotton, herbicide tolerance, not deposited, described in US2002120964 or WO2002/034946); Event 17053 (rice, herbicide tolerance, deposited as PTA-9843, described in WO2010/117737); Event 17314 (rice, herbicide tolerance, deposited as PTA-9844, described in WO2010/117735); Event 281-24-236 (cotton, insect control—herbicide tolerance, deposited as PTA-6233, described in WO2005/103266 or US2005216969); Event 3006-210-23 (cotton, insect control—herbicide tolerance, deposited as PTA-6233, described in US2007143876 or WO2005/103266); Event 3272 (corn, quality trait, deposited as PTA-9972, described in WO2006098952 or US2006230473); Event 40416 (corn, insect control—herbicide tolerance, deposited as ATCC PTA-11508, described in WO2011/075593); Event 43A47 (corn, insect control—herbicide tolerance, deposited as ATCC PTA-11509, described in WO2011/075595); Event 5307 (corn, insect control, deposited as ATCC PTA-9561, described in WO2010/077816); Event ASR-368 (bent grass, herbicide tolerance, deposited as ATCC PTA-4816, described in US2006162007 or WO2004053062); Event B16 (corn, herbicide tolerance, not deposited, described in US2003126634); Event BPS-CV127-9 (soybean, herbicide tolerance, deposited as NCIMB No. 41603, described in WO2010/080829); Event CE43-67B (cotton, insect control, deposited as DSM ACC2724, described in US2009217423 or WO2006/128573); Event CE44-69D (cotton, insect control, not deposited, described in US20100024077); Event CE44-69D (cotton, insect control, not deposited, described in WO2006/128571); Event CE46-02A (cotton, insect control, not deposited, described in WO2006/128572); Event COT102 (cotton, insect control, not deposited, described in US2006130175 or WO2004039986); Event COT202 (cotton, insect control, not deposited, described in US2007067868 or WO2005054479); Event COT203 (cotton, insect control, not deposited, described in WO2005/054480); Event DAS40278 (corn, herbicide tolerance, deposited as ATCC PTA-10244, described in WO2011/022469); Event DAS-59122-7 (corn, insect control—herbicide tolerance, deposited as ATCC PTA 11384, described in US2006070139); Event DAS-59132 (corn, insect control—herbicide tolerance, not deposited, described in WO2009/100188); Event DAS68416 (soybean, herbicide tolerance, deposited as ATCC PTA-10442, described in WO2011/066384 or WO2011/066360); Event DP-098140-6 (corn, herbicide tolerance, deposited as ATCC PTA-8296, described in US2009137395 or WO2008/112019); Event DP-305423-1 (soybean, quality trait, not deposited, described in US2008312082 or WO2008/054747); Event DP-32138-1 (corn, hybridization system, deposited as ATCC PTA-9158, described in US20090210970 or WO2009/103049); Event DP-356043-5 (soybean, herbicide tolerance, deposited as ATCC PTA-8287, described in US20100184079 or WO2008/002872); Event EE-1 (brinjal, insect control, not deposited, described in WO2007/091277); Event FI117 (corn, herbicide tolerance, deposited as ATCC 209031, described in US2006059581 or WO1998/044140); Event GA21 (corn, herbicide tolerance, deposited as ATCC 209033, described in US2005086719 or WO1998/044140); Event GG25 (corn, herbicide tolerance, deposited as ATCC 209032, described in US2005188434 or WO1998/044140); Event GHB119 (cotton, insect control—herbicide tolerance, deposited as ATCC PTA-8398, described in WO2008/151780); Event GHB614 (cotton, herbicide tolerance, deposited as ATCC PTA-6878, described in US2010050282 or WO2007/017186); Event GJ11 (corn, herbicide tolerance, deposited as ATCC 209030, described in US2005188434 or WO1998/044140); Event GM RZ13 (sugar beet, virus resistance, deposited as NCIMB-41601, described in WO2010/076212); Event H7-1 (sugar beet, herbicide tolerance, deposited as NCIMB 41158 or NCIMB 41159, described in US2004172669 or WO2004/074492); Event JOPLIN1 (wheat, disease tolerance, not deposited, described in US2008064032); Event LL27 (soybean, herbicide tolerance, deposited as NCIMB41658, described in WO2006/108674 or US2008320616); Event LL55 (soybean, herbicide tolerance, deposited as NCIMB 41660, described in WO2006/108675 or US2008196127); Event LLcotton25 (cotton, herbicide tolerance, deposited as ATCC PTA-3343, described in WO2003013224 or US2003097687); Event LLRICE06 (rice, herbicide tolerance, deposited as ATCC-23352, described in U.S. Pat. No. 6,468,747 or WO2000/026345); Event LLRICE601 (rice, herbicide tolerance, deposited as ATCC PTA-2600, described in US20082289060 or WO2000/026356); Event LY038 (corn, quality trait, deposited as ATCC PTA-5623, described in US2007028322 or WO2005061720); Event MIR162 (corn, insect control, deposited as PTA-8166, described in US2009300784 or WO2007/142840); Event MIR604 (corn, insect control, not deposited, described in US2008167456 or WO2005103301); Event MON15985 (cotton, insect control, deposited as ATCC PTA-2516, described in US2004-250317 or WO2002/100163); Event MON810 (corn, insect control, not deposited, described in US2002102582); Event MON863 (corn, insect control, deposited as ATCC PTA-2605, described in WO2004/011601 or US2006095986); Event MON87427 (corn, pollination control, deposited as ATCC PTA-7899, described in WO2011/062904); Event MON87460 (corn, stress tolerance, deposited as ATCC PTA-8910, described in WO2009/111263 or US20110138504); Event MON87701 (soybean, insect control, deposited as ATCC PTA-8194, described in US2009130071 or WO2009/064652); Event MON87705 (soybean, quality trait—herbicide tolerance, deposited as ATCC PTA-9241, described in US20100080887 or WO2010/037016); Event MON87708 (soybean, herbicide tolerance, deposited as ATCC PTA9670, described in WO2011/034704); Event MON87754 (soybean, quality trait, deposited as ATCC PTA-9385, described in WO2010/024976); Event MON87769 (soybean, quality trait, deposited as ATCC PTA-8911, described in US20110067141 or WO2009/102873); Event MON88017 (corn, insect control—herbicide tolerance, deposited as ATCC PTA-5582, described in US2008028482 or WO2005/059103); Event MON88913 (cotton, herbicide tolerance, deposited as ATCC PTA-4854, described in WO2004/072235 or US2006059590); Event MON89034 (corn, insect control, deposited as ATCC PTA-7455, described in WO2007/140256 or US2008260932); Event MON89788 (soybean, herbicide tolerance, deposited as ATCC PTA-6708, described in US2006282915 or WO2006/130436); Event MS11 (oilseed rape, pollination control—herbicide tolerance, deposited as ATCC PTA-850 or PTA-2485, described in WO2001/031042); Event MS8 (oilseed rape, pollination control—herbicide tolerance, deposited as ATCC PTA-730, described in WO2001/041558 or US2003188347); Event NK603 (corn, herbicide tolerance, deposited as ATCC PTA-2478, described in US2007-292854); Event PE-7 (rice, insect control, not deposited, described in WO2008/114282); Event RF3 (oilseed rape, pollination control—herbicide tolerance, deposited as ATCC PTA-730, described in WO2001/041558 or US2003188347); Event RT73 (oilseed rape, herbicide tolerance, not deposited, described in WO2002/036831 or US2008070260); Event T227-1 (sugar beet, herbicide tolerance, not deposited, described in WO2002/44407 or US2009265817); Event T25 (corn, herbicide tolerance, not deposited, described in US2001029014 or WO2001/051654); Event T304-40 (cotton, insect control—herbicide tolerance, deposited as ATCC PTA-8171, described in US2010077501 or WO2008/122406); Event T342-142 (cotton, insect control, not deposited, described in WO2006/128568); Event TC1507 (corn, insect control—herbicide tolerance, not deposited, described in US2005039226 or WO2004/099447); Event VIP1034 (corn, insect control—herbicide tolerance, deposited as ATCC PTA-3925, described in WO2003/052073), Event 32316 (corn, insect control-herbicide tolerance, deposited as PTA-11507, described in WO2011/084632), Event 4114 (corn, insect control-herbicide tolerance, deposited as PTA-11506, described in WO2011/084621).


Plants that may be treated according to the invention are hybrid plants that already express the characteristic of heterosis or hybrid vigor which results in generally higher yield, vigor, health and resistance towards biotic and abiotic stresses). Such plants are typically made by crossing an inbred male-sterile parent line (the female parent) with another inbred male-fertile parent line (the male parent). Hybrid seed is typically harvested from the male sterile plants and sold to growers. Male sterile plants can sometimes (e.g. in corn) be produced by detasseling, i.e. the mechanical removal of the male reproductive organs (or males flowers) but, more typically, male sterility is the result of genetic determinants in the plant genome. In that case, and especially when seed is the desired product to be harvested from the hybrid plants it is typically useful to ensure that male fertility in the hybrid plants is fully restored. This can be accomplished by ensuring that the male parents have appropriate fertility restorer genes which are capable of restoring the male fertility in hybrid plants that contain the genetic determinants responsible for male-sterility. Genetic determinants for male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) were for instance described in Brassica species (WO 92/05251, WO 95/09910, WO 98/27806, WO 05/002324, WO 06/021972 and U.S. Pat. No. 6,229,072). However, genetic determinants for male sterility can also be located in the nuclear genome. Male sterile plants can also be obtained by plant biotechnology methods such as genetic engineering. A particularly useful means of obtaining male-sterile plants is described in WO 89/10396 in which, for example, a ribonuclease such as barnase is selectively expressed in the tapetum cells in the stamens. Fertility can then be restored by expression in the tapetum cells of a ribonuclease inhibitor such as barstar (e.g. WO 91/02069).


Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may be treated according to the invention are herbicide-tolerant plants, i.e. plants made tolerant to one or more given herbicides. Such plants can be obtained either by genetic transformation, or by selection of plants containing a mutation imparting such herbicide tolerance.


Herbicide-resistant plants are for example glyphosate-tolerant plants, i.e. plants made tolerant to the herbicide glyphosate or salts thereof. Plants can be made tolerant to glyphosate through different means. For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Comai et al., 1983, Science 221, 370-371), the CP4 gene of the bacterium Agrobacterium sp. (Barry et al., 1992, Curr. Topics Plant Physiol. 7, 139-145), the genes encoding a Petunia EPSPS (Shah et al., 1986, Science 233, 478-481), a Tomato EPSPS (Gasser et al., 1988, J. Biol. Chem. 263, 4280-4289), or an Eleusine EPSPS (WO 01/66704). It can also be a mutated EPSPS as described in for example EP 0837944, WO 00/66746, WO 00/66747 or WO02/26995. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxido-reductase enzyme as described in U.S. Pat. Nos. 5,776,760 and 5,463,175. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate acetyl transferase enzyme as described in for example WO 02/36782, WO 03/092360, WO 05/012515 and WO 07/024,782. Glyphosate-tolerant plants can also be obtained by selecting plants containing naturally-occurring mutations of the above-mentioned genes, as described in for example WO 01/024615 or WO 03/013226. Plants expressing EPSPS genes that confer glyphosate tolerance are described in e.g. U.S. patent application Ser. Nos. 11/517,991, 10/739,610, 12/139,408, 12/352,532, 11/312,866, 11/315,678, 12/421,292, 11/400,598, 11/651,752, 11/681,285, 11/605,824, 12/468,205, 11/760,570, 11/762,526, 11/769,327, 11/769,255, 11/943,801 or 12/362,774. Plants comprising other genes that confer glyphosate tolerance, such as decarboxylase genes, are described in e.g. U.S. patent application Ser. Nos. 11/588,811, 11/185,342, 12/364,724, 11/185,560 or 12/423,926.


Other herbicide resistant plants are for example plants that are made tolerant to herbicides inhibiting the enzyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such plants can be obtained by expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase enzyme that is resistant to inhibition, e.g. described in U.S. patent application Ser. No. 11/760,602. One such efficient detoxifying enzyme is an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinothricin acetyltransferase are for example described in U.S. Pat. Nos. 5,561,236; 5,648,477; 5,646,024; 5,273,894; 5,637,489; 5,276,268; 5,739,082; 5,908,810 and 7,112,665.


Further herbicide-tolerant plants are also plants that are made tolerant to the herbicides inhibiting the enzyme hydroxyphenylpyruvatedioxygenase (HPPD). HPPD is an enzyme that catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants tolerant to HPPD-inhibitors can be transformed with a gene encoding a naturally-occurring resistant HPPD enzyme, or a gene encoding a mutated or chimeric HPPD enzyme as described in WO 96/38567, WO 99/24585, WO 99/24586, WO 2009/144079, WO 2002/046387, or U.S. Pat. No. 6,768,044. Tolerance to HPPD-inhibitors can also be obtained by transforming plants with genes encoding certain enzymes enabling the formation of homogentisate despite the inhibition of the native HPPD enzyme by the HPPD-inhibitor. Such plants and genes are described in WO 99/34008 and WO 02/36787. Tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding an enzyme having prephenate deshydrogenase (PDH) activity in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO 2004/024928. Further, plants can be made more tolerant to HPPD-inhibitor herbicides by adding into their genome a gene encoding an enzyme capable of metabolizing or degrading HPPD inhibitors, such as the CYP450 enzymes shown in WO 2007/103567 and WO 2008/150473.


Still further herbicide resistant plants are plants that are made tolerant to acetolactate synthase (ALS) inhibitors. Known ALS-inhibitors include, for example, sulfonylurea, imidazolinone, triazolopyrimidines, pryimidinyoxy(thio)benzoates, and/or sulfonylaminocarbonyltriazolinone herbicides. Different mutations in the ALS enzyme (also known as acetohydroxyacid synthase, AHAS) are known to confer tolerance to different herbicides and groups of herbicides, as described for example in Tranel and Wright (2002, Weed Science 50:700-712), but also, in U.S. Pat. Nos. 5,605,011, 5,378,824, 5,141,870, and 5,013,659. The production of sulfonylurea-tolerant plants and imidazolinone-tolerant plants is described in U.S. Pat. Nos. 5,605,011; 5,013,659; 5,141,870; 5,767,361; 5,731,180; 5,304,732; 4,761,373; 5,331,107; 5,928,937; and 5,378,824; and international publication WO 96/33270. Other imidazolinone-tolerant plants are also described in for example WO 2004/040012, WO 2004/106529, WO 2005/020673, WO 2005/093093, WO 2006/007373, WO 2006/015376, WO 2006/024351, and WO 2006/060634. Further sulfonylurea- and imidazolinone-tolerant plants are also described in for example WO 07/024,782 and U.S. Patent Application No. 61/288,958.


Other plants tolerant to imidazolinone and/or sulfonylurea can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or mutation breeding as described for example for soybeans in U.S. Pat. No. 5,084,082, for rice in WO 97/41218, for sugar beet in U.S. Pat. No. 5,773,702 and WO 99/057965, for lettuce in U.S. Pat. No. 5,198,599, or for sunflower in WO 01/065922.


Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are insect-resistant transgenic plants, i.e. plants made resistant to attack by certain target insects. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such insect resistance.


An “insect-resistant transgenic plant”, as used herein, includes any plant containing at least one transgene comprising a coding sequence encoding:

    • 1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal portion thereof, such as the insecticidal crystal proteins listed by Crickmore et al. (1998, Microbiology and Molecular Biology Reviews, 62: 807-813), updated by Crickmore et al. (2005) at the Bacillus thuringiensis toxin nomenclature, online at: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or insecticidal portions thereof, e.g., proteins of the Cry protein classes Cry1Ab, Cry1Ac, Cry1B, Cry1C, Cry1D, Cry1F, Cry2Ab, Cry3Aa, or Cry3Bb or insecticidal portions thereof (e.g. EP 1999141 and WO 2007/107302), or such proteins encoded by synthetic genes as e.g. described in and U.S. patent application Ser. No. 12/249,016; or
    • 2) a crystal protein from Bacillus thuringiensis or a portion thereof which is insecticidal in the presence of a second other crystal protein from Bacillus thuringiensis or a portion thereof, such as the binary toxin made up of the Cry34 and Cry35 crystal proteins (Moellenbeck et al. 2001, Nat. Biotechnol. 19: 668-72; Schnepf et al. 2006, Applied Environm. Microbiol. 71, 1765-1774) or the binary toxin made up of the Cry1A or Cry1F proteins and the Cry2Aa or Cry2Ab or Cry2Ae proteins (U.S. patent application Ser. No. 12/214,022 and EP 08010791.5); or
    • 3) a hybrid insecticidal protein comprising parts of different insecticidal crystal proteins from Bacillus thuringiensis, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2) above, e.g., the Cry1A.105 protein produced by corn event MON89034 (WO 2007/027777); or
    • 4) a protein of any one of 1) to 3) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation, such as the Cry3Bb1 protein in corn events MON863 or MON88017, or the Cry3A protein in corn event MIR604; or
    • 5) an insecticidal secreted protein from Bacillus thuringiensis or Bacillus cereus, or an insecticidal portion thereof, such as the vegetative insecticidal (VIP) proteins listed at:
    • http://www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt/vip.html, e.g., proteins from the VIP3Aa protein class; or
    • 6) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin made up of the VIP1A and VIP2A proteins (WO 94/21795); or
    • 7) a hybrid insecticidal protein comprising parts from different secreted proteins from Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins in 1) above or a hybrid of the proteins in 2) above; or
    • 8) a protein of any one of 5) to 7) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein), such as the VIP3Aa protein in cotton event COT102; or
    • 9) a secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a crystal protein from Bacillus thuringiensis, such as the binary toxin made up of VIP3 and Cry1A or Cry1F (U.S. Patent Appl. Nos. 61/126,083 and 61/195,019), or the binary toxin made up of the VIP3 protein and the Cry2Aa or Cry2Ab or Cry2Ae proteins (U.S. patent application Ser. No. 12/214,022 and EP 08010791.5).
    • 10) a protein of 9) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein)


Of course, an insect-resistant transgenic plant, as used herein, also includes any plant comprising a combination of genes encoding the proteins of any one of the above classes 1 to 10. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein of any one of the above classes 1 to 10, to expand the range of target insect species affected when using different proteins directed at different target insect species, or to delay insect resistance development to the plants by using different proteins insecticidal to the same target insect species but having a different mode of action, such as binding to different receptor binding sites in the insect.


An “insect-resistant transgenic plant”, as used herein, further includes any plant containing at least one transgene comprising a sequence producing upon expression a double-stranded RNA which upon ingestion by a plant insect pest inhibits the growth of this insect pest, as described e.g. in WO 2007/080126, WO 2006/129204, WO 2007/074405, WO 2007/080127 and WO 2007/035650.


Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are tolerant to abiotic stresses. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such stress resistance. Particularly useful stress tolerance plants include:

    • 1) plants which contain a transgene capable of reducing the expression and/or the activity of poly(ADP-ribose) polymerase (PARP) gene in the plant cells or plants as described in WO 00/04173, WO/2006/045633, EP 04077984.5, or EP 06009836.5.
    • 2) plants which contain a stress tolerance enhancing transgene capable of reducing the expression and/or the activity of the PARG encoding genes of the plants or plants cells, as described e.g. in WO 2004/090140.
    • 3) plants which contain a stress tolerance enhancing transgene coding for a plant-functional enzyme of the nicotineamide adenine dinucleotide salvage synthesis pathway including nicotinamidase, nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyl transferase, nicotinamide adenine dinucleotide synthetase or nicotine amide phosphorybosyltransferase as described e.g. in EP 04077624.7, WO 2006/133827, PCT/EP07/002,433, EP 1999263, or WO 2007/107326.


Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention show altered quantity, quality and/or storage-stability of the harvested product and/or altered properties of specific ingredients of the harvested product such as:

    • 1) transgenic plants which synthesize a modified starch, which in its physical-chemical characteristics, in particular the amylose content or the amylose/amylopectin ratio, the degree of branching, the average chain length, the side chain distribution, the viscosity behaviour, the gelling strength, the starch grain size and/or the starch grain morphology, is changed in comparison with the synthesised starch in wild type plant cells or plants, so that this is better suited for special applications. Said transgenic plants synthesizing a modified starch are disclosed, for example, in EP 0571427, WO 95/04826, EP 0719338, WO 96/15248, WO 96/19581, WO 96/27674, WO 97/11188, WO 97/26362, WO 97/32985, WO 97/42328, WO 97/44472, WO 97/45545, WO 98/27212, WO 98/40503, WO99/58688, WO 99/58690, WO 99/58654, WO 00/08184, WO 00/08185, WO 00/08175, WO 00/28052, WO 00/77229, WO 01/12782, WO 01/12826, WO 02/101059, WO 03/071860, WO 2004/056999, WO 2005/030942, WO 2005/030941, WO 2005/095632, WO 2005/095617, WO 2005/095619, WO 2005/095618, WO 2005/123927, WO 2006/018319, WO 2006/103107, WO 2006/108702, WO 2007/009823, WO 00/22140, WO 2006/063862, WO 2006/072603, WO 02/034923, EP 06090134.5, EP 06090228.5, EP 06090227.7, EP 07090007.1, EP 07090009.7, WO 01/14569, WO 02/79410, WO 03/33540, WO 2004/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO 99/12950, WO 99/66050, WO 99/53072, U.S. Pat. No. 6,734,341, WO 00/11192, WO 98/22604, WO 98/32326, WO 01/98509, WO 01/98509, WO 2005/002359, U.S. Pat. No. 5,824,790, U.S. Pat. No. 6,013,861, WO 94/04693, WO 94/09144, WO 94/11520, WO 95/35026, WO 97/20936, WO 10/012,796, WO 10/003,701
    • 2) transgenic plants which synthesize non starch carbohydrate polymers or which synthesize non starch carbohydrate polymers with altered properties in comparison to wild type plants without genetic modification. Examples are plants producing polyfructose, especially of the inulin and levan-type, as disclosed in EP 0663956, WO 96/01904, WO 96/21023, WO 98/39460, and WO 99/24593, plants producing alpha-1,4-glucans as disclosed in WO 95/31553, US 2002031826, U.S. Pat. No. 6,284,479, U.S. Pat. No. 5,712,107, WO 97/47806, WO 97/47807, WO 97/47808 and WO 00/14249, plants producing alpha-1,6 branched alpha-1,4-glucans, as disclosed in WO 00/73422, plants producing alternan, as disclosed in e.g. WO 00/47727, WO 00/73422, EP 06077301.7, U.S. Pat. No. 5,908,975 and EP 0728213,
    • 3) transgenic plants which produce hyaluronan, as for example disclosed in WO 2006/032538, WO 2007/039314, WO 2007/039315, WO 2007/039316, JP 2006304779, and WO 2005/012529.
    • 4) transgenic plants or hybrid plants, such as onions with characteristics such as ‘high soluble solids content’, ‘low pungency’ (LP) and/or ‘long storage’ (LS), as described in U.S. patent application Ser. No. 12/020,360 and 61/054,026.


Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as cotton plants, with altered fiber characteristics. Such plants can be obtained by genetic transformation, or by selection of plants contain a mutation imparting such altered fiber characteristics and include:

    • a) Plants, such as cotton plants, containing an altered form of cellulose synthase genes as described in WO 98/00549
    • b) Plants, such as cotton plants, containing an altered form of rsw2 or rsw3 homologous nucleic acids as described in WO 2004/053219
    • c) Plants, such as cotton plants, with increased expression of sucrose phosphate synthase as described in WO 01/17333
    • d) Plants, such as cotton plants, with increased expression of sucrose synthase as described in WO 02/45485
    • e) Plants, such as cotton plants, wherein the timing of the plasmodesmatal gating at the basis of the fiber cell is altered, e.g. through downregulation of fiber-selective β-1,3-glucanase as described in WO 2005/017157, or as described in EP 08075514.3 or U.S. Patent Appl. No. 61/128,938
    • f) Plants, such as cotton plants, having fibers with altered reactivity, e.g. through the expression of N-acetylglucosaminetransferase gene including nodC and chitin synthase genes as described in WO 2006/136351


Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered oil profile characteristics. Such plants can be obtained by genetic transformation, or by selection of plants contain a mutation imparting such altered oil profile characteristics and include:

    • a) Plants, such as oilseed rape plants, producing oil having a high oleic acid content as described e.g. in U.S. Pat. No. 5,969,169, U.S. Pat. No. 5,840,946 or U.S. Pat. No. 6,323,392 or U.S. Pat. No. 6,063,947
    • b) Plants such as oilseed rape plants, producing oil having a low linolenic acid content as described in U.S. Pat. No. 6,270,828, U.S. Pat. No. 6,169,190, or U.S. Pat. No. 5,965,755
    • c) Plant such as oilseed rape plants, producing oil having a low level of saturated fatty acids as described e.g. in U.S. Pat. No. 5,434,283 or U.S. patent application Ser. No. 12/668,303


Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered seed shattering characteristics. Such plants can be obtained by genetic transformation, or by selection of plants contain a mutation imparting such altered seed shattering characteristics and include plants such as oilseed rape plants with delayed or reduced seed shattering as described in U.S. Patent Appl. No. 61/135,230, WO09/068,313 and WO10/006,732.


Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as Tobacco plants, with altered post-translational protein modification patterns, for example as described in WO 10/121,818 and WO 10/145,846.


Particularly useful transgenic plants which may be treated according to the invention are plants containing transformation events, or combination of transformation events, that are the subject of petitions for non-regulated status, in the United States of America, to the Animal and Plant Health Inspection Service (APHIS) of the United States Department of Agriculture (USDA) whether such petitions are granted or are still pending. At any time this information is readily available from APHIS (4700 River Road Riverdale, Md. 20737, USA), for instance on its internet site (URL http://www.aphis.usda.gov/brs/not_reg.html). On the filing date of this application the petitions for nonregulated status that were pending with APHIS or granted by APHIS were those listed in Table B which contains the following information:

    • Petition: the identification number of the petition. Technical descriptions of the transformation events can be found in the individual petition documents which are obtainable from APHIS, for example on the APHIS website, by reference to this petition number. These descriptions are herein incorporated by reference.
    • Extension of Petition: reference to a previous petition for which an extension is requested.
    • Institution: the name of the entity submitting the petition.
    • Regulated article: the plant species concerned.
    • Transgenic phenotype: the trait conferred to the plants by the transformation event.
    • Transformation event or line: the name of the event or events (sometimes also designated as lines or lines) for which nonregulated status is requested.
    • APHIS documents: various documents published by APHIS in relation to the Petition and which can be requested with APHIS.









TABLE B







Non-exhaustive lists of transgenic plants and events for the conduction of experiments according to the


invention obtained from the APHIS- data base of the United States Department of Agriculture (USDA).


The data base can be found under the following link:


http://www.aphis.usda.gov/animal_welfare/efoia/index.shtml.















Extension








of Petition


Transgenic
Transformation


No
Petition
Number ***
Institution
Crop
Phenotype
Event or Line





B-1
10-070-01p

Virginia Tech
Peanut
Sclerotinia blight
N70, P39, and







resistant
W171


B-2
09-349-01p

Dow
Soybean
2,4-D and
DAS-68416-4





AgroSciences

glufosinate








tolerant



B-3
09-328-01p

Bayer Crop
Soybean
glyphosate and
FG72





Science

isoxaflutole








tolerant



B-4
09-233-01p

Dow
Corn
2,4-D and
DAS-40278-9







ACCase-inhibitor








tolerant



B-5
09-201-01p

Monsanto
Soybean
improved fatty
MON-877∅5-6







acid profile



B-6
09-183-01p

Monsanto
Soybean
stearidonic acid
MON-87769







produced



B-7
09-082-01p

Monsanto
Soybean
Lepidopteran
MON 87701







resistant



B-8
09-063-01p

Stine Seed
Corn
Glyphosate
HCEM485







tolerant



B-9
09-055-01p

Monsanto
Corn
Drought Tolerant
MON 87460


B-10
09-015-01p

BASF Plant
Soybean
imidazolinone
BPS-CV127-9





Science, LLC

tolerant
Soybean


B-11
08-366-01p

ArborGen
Eucalyptus
Freeze Tolerant,
ARB-FTE1-08







Fertility Altered



B-12
08-340-01p

Bayer
Cotton
Glufosinate
T304-







Tolerant, Insect
40XGHB119







Resistant



B-13
08-338-01p

Pioneer
Corn
Male Sterile,
DP-32138-1







Fertility








Restored, Visual








Marker



B-14
08-315-01p

Florigene
Rose
Altered Flower
IFD-524∅1-4







Color
and IFD-529∅1-9


B-15
07-108-01p

Syngenta
Cotton
Lepidopteran
COT67B







Resistant



B-16
06-354-01p

Pioneer
Soybean
High Oleic Acid
DP-3∅5423-1


B-17
05-280-01p

Syngenta
Corn
Thermostable
3272







alpha-amylase



B-18
04-110-01p

Monsanto &
Alfalfa
Glyphosate
J101, J163





Forage

Tolerant






Genetics





B-19
03-104-01p

Monsanto &
Creeping
Glyphosate
ASR368





Scotts
bentgrass
Tolerant



B-20
07-253-01p

Syngenta
Corn
Lepidopteran
MIR-162 Maize







resistant



B-21
07-152-01p

Pioneer
Corn
glyphosate &
DP-098140-6







Imidazolinone








tolerant



B-22
04-337-01p

University of
Papaya
Papaya Ringspot
X17-2





Florida

Virus Resistant



B-23
06-332-01p

Bayer
Cotton
Glyphosate
GHB614





CropScience

tolerant



B-24
06-298-01p

Monsanto
Corn
European Corn
MON 89034







Borer resistant



B-25
06-271-01p

Pioneer
Soybean
Glyphosate &
356043







acetolactate
(DP-356∅43-5)







synthase tolerant



B-26
06-234-01p
98-329-01p
Bayer
Rice
Phosphinothricin
LLRICE601





CropScience

tolerant



B-27
06-178-01p

Monsanto
Soybean
Glyphosate
MON 89788







tolerant



B-28
04-362-01p

Syngenta
Corn
Corn Rootworm
MIR604







Protected



B-29
04-264-01p

ARS
Plum
Plum Pox Virus
C5







Resistant



B-30
04-229-01p

Monsanto
Corn
High Lysine
LY038


B-31
04-125-01p

Monsanto
Corn
Corn Rootworm
88017







Resistant



B-32
04-086-01p

Monsanto
Cotton
Glyphosate
MON 88913







Tolerant



B-33
03-353-01p

Dow
Corn
Corn Rootworm
59122







Resistant



B-34
03-323-01p

Monsanto
Sugar Beet
Glyphosate
H7-1







Tolerant



B-35
03-181-01p
00-136-01p
Dow
Corn
Lepidopteran
TC-6275







Resistant &








Phosphinothricin








tolerant



B-36
03-155-01p

Syngenta
Cotton
Lepidopteran
COT 102







Resistant



B-37
03-036-01p

Mycogen/Dow
Cotton
Lepidopteran
281-24-236







Resistant



B-38
03-036-02p

Mycogen/Dow
Cotton
Lepidopteran
3006-210-23







Resistant



B-39
02-042-01p

Aventis
Cotton
Phosphinothericin
LLCotton25







tolerant



B-40
01-324-01p
98-216-01p
Monsanto
Rapeseed
Glyphosate
RT200







tolerant



B-41
01-206-01p
98-278-01p
Aventis
Rapeseed
Phosphinothricin
MS1 & RF1/RF2







tolerant &








pollination








control



B-42
01-206-02p
97-205-01p
Aventis
Rapeseed
Phosphinothricin
Topas 19/2







tolerant



B-43
01-137-01p

Monsanto
Corn
Corn Rootworm
MON 863







Resistant



B-44
01-121-01p

Vector
Tobacco
Reduced nicotine
Vector 21-41


B-45
00-342-01p

Monsanto
Cotton
Lepidopteran
Cotton Event







resistant
15985


B-46
00-136-01p

Mycogen c/o
Corn
Lepidopteran
Line 1507





Dow & Pioneer

resistant








tolerant
phosphinothricin


B-47
00-011-01p
97-099-01p
Monsanto
Corn
Glyphosate
NK603







tolerant



B-48
99-173-01p
97-204-01p
Monsanto
Potato
PLRV & CPB
RBMT22-82







resistant



B-49
98-349-01p
95-228-01p
AgrEvo
Corn
Phosphinothricin
MS6







tolerant and








Males terile



B-50
98-335-01p

U. of
Flax
Tolerant to soil
CDC Triffid





Saskatchewan

residues of








sulfonyl urea








herbicide



B-51
98-329-01p

AgrEvo
Rice
Phosphinothricin
LLRICE06,







tolerant
LLRICE62


B-52
98-278-01p

AgrEvo
Rapeseed
Phosphinothricin
MS8 & RF3







tolerant &








Pollination








control



B-53
98-238-01p

AgrEvo
Soybean
Phosphinothricin
GU262







tolerant



B-54
98-216-01p

Monsanto
Rapeseed
Glyphosate
RT73







tolerant



B-55
98-173-01p

Novartis Seeds
Beet
Glyphosate
GTSB77





& Monsanto

tolerant



B-56
98-014-01p
96-068-01p
AgrEvo
Soybean
Phosphinothricin
A5547-127







tolerant



B-57
97-342-01p

Pioneer
Corn
Male sterile &
676, 678, 680







Phosphinothricin








tolerant



B-58
97-339-01p

Monsanto
Potato
CPB & PVY
RBMT15-101,







resistant
SEMT15-02,








SEMT15-15


B-59
97-336-01p

AgrEvo
Beet
Phosphinothricin
T-120-7







tolerant



B-60
97-287-01p

Monsanto
Tomato
Lepidopteran
5345







resistant



B-61
97-265-01p

AgrEvo
Corn
Phosphinothricin
CBH-351







tolerant & Lep.








resistant



B-62
97-205-01p

AgrEvo
Rapeseed
Phosphinothricin
T45







tolerant



B-63
97-204-01p

Monsanto
Potato
CPB & PLRV
RBMT21-129 &







resistant
RBMT21-350


B-64
97-148-01p

Bejo
Cichorium
Male sterile
RM3-3, RM3-4,






intybus

RM3-6


B-65
97-099-01p

Monsanto
Corn
Glyphosate
GA21







tolerant



B-66
97-013-01p

Calgene
Cotton
Bromoxynil
Events 31807 &







tolerant &
31808







Lepidopteran








resistant



B-67
97-008-01p

Du Pont
Soybean
Oil profile altered
G94-1, G94-19,








G-168


B-68
96-317-01p

Monsanto
Corn
Glyphosate
MON802







tolerant & ECB








resistant



B-69
96-291-01p

DeKalb
Corn
European Corn
DBT418







Borer resistant



B-70
96-248-01p
92-196-01p
Calgene
Tomato
Fruit ripening
1 additional







altered
FLAVRSAVR








line


B-71
96-068-01p

AgrEvo
Soybean
Phosphinothricin
W62, W98,







tolerant
A2704-12,








A2704-21,








A5547-35


B-72
96-051-01p

Cornell U
Papaya
PRSV resistant
55-1, 63-1


B-73
96-017-01p
95-093-01p
Monsanto
Corn
European Corn
MON809 &







Borer resistant
MON810


B-74
95-352-01p

Asgrow
Squash
CMV, ZYMV,
CZW-3







WMV2 resistant



B-75
95-338-01p

Monsanto
Potato
CPB resistant
SBT02-5 & −7,








ATBT04-6 & −27,








−30, −31, −36


B-76
95-324-01p

Agritope
Tomato
Fruit ripening
35 1 N







altered



B-77
95-256-01p

Du Pont
Cotton
Sulfonylurea
19-51a







tolerant



B-78
95-228-01p

Systems
Corn
Plant Genetic
MS3







Male sterile



B-79
95-195-01p

Northrup King
Corn
European Corn
Bt11







Borer resistant



B-80
95-179-01p
92-196-01p
Calgene
Tomato
Fruit ripening
2 additional







altered
FLAVRSAVR








lines


B-81
95-145-01p

DeKalb
Corn
Phosphinothricin
B16







tolerant



B-82
95-093-01p

Monsanto
Corn
Lepidopteran
MON 80100







resistant



B-83
95-053-01p

Monsanto
Tomato
Fruit ripening
8338







altered



B-84
95-045-01p

Monsanto
Cotton
Glyphosate
1445, 1698







tolerant



B-85
95-030-01p
92-196-01p
Calgene
Tomato
Fruit ripening
20 additional







altered









FLAVRSAVR








lines


B-86
94-357-01p

AgrEvo
Corn
Phosphinothricin
T14, T25







tolerant



B-87
94-319-01p

Ciba Seeds
Corn
Lepidopteran
Event 176







resistant



B-88
94-308-01p

Monsanto
Cotton
Lepidopteran
531, 757, 1076







resistant



B-89
94-290-01p

Zeneca &
Tomato
Fruit
B, Da, F





Petoseed

polygalacturonase








level decreased



B-90
94-257-01p

Monsanto
Potato
Coleopteran
BT6, BT10,







resistant
BT12, BT16,








BT17, BT18,








BT23


B-91
94-230-01p
92-196-01p
Calgene
Tomato
Fruit ripening
9 additional







altered
FLAVRSAVR








lines


B-92
94-228-01p

DNA Plant
Tomato
Fruit ripening
1345-4





Tech

altered



B-93
94-227-0 1p
92-196-01p
Calgene
Tomato
Fruit ripening
Line N73 1436-111







altered



B-94
94-090-01p

Calgene
Rapeseed
Oil profile altered
pCGN3828-








212/86- 18 & 23


B-95
93-258-01p

Monsanto
Soybean
Glyphosate
40-3-2







tolerant



B-96
93-196-01p

Calgene
Cotton
Bromoxynil
BXN







tolerant



B-97
92-204-01p

Upjohn
Squash
WMV2 &
ZW-20







ZYMV resistant



B-98
92-196-01p

Calgene
Tomato
Fruit ripening
FLAVR SAVR







altered





Abbreviation used in this table:


CMV—Cucumber Mosaic Virus


CPB—Colorado potato beetle


PLRV—Potato Leaf Roll Virus


PRSV—Papaya Ringspot Virus


PVY—Potato Virus Y


WMV2—Watermelon Mosaic Virus 2


ZYMV—Zucchini Yellow Mosaic Virus






Additional particularly useful plants which may be treated according to the invention containing single transformation events or combinations of transformation events are listed for example in the databases from various national or regional regulatory agencies (see for example http://gmoinfo.jrc.it/gmp_browse.aspx and http://www.agbios.com/dbase.php).


Further particularly transgenic plants include plants which may be treated according to the invention containing a transgene in an agronomically neutral or beneficial position as described in any of the patent publications listed in Table C.









TABLE C







Non-exhaustive list of traits for the conduction of experiments


with a compound of formula (I), formula (I-1-1), or formula


(I-1-2) or a mixture of two compounds (I-1-1)/(I-1-7), or


(I-1-2)/(I-1-8) or a composition comprising a compound of the


formula (1) with a further agrochemically active ingredient


according to the present invention.











No.
Trait
Reference






C-1
Water use efficiency
WO 2000/073475





WO2009/150541





WO2009/150541



C-2
Nitrogen use efficiency
WO 1995/009911





WO 1997/030163





WO 2007/092704





WO 2007/076115





WO 2005/103270





WO 2002/002776





WO2008/051608





WO2008/112613





WO2008/112613





WO2008/118394





WO2009/015096





WO2009/061776





WO2009/105492





WO2009/105612





WO2009/117853





WO2010/006010





WO2009/117853





WO2009/061776





WO2009/015096





WO2009/105492





WO2009/105612





WO2010/007496





WO2010/036866





WO2010/053621





WO2010/053867





WO2010/077890





WO2010/086220





WO2010/111568





WO2010/140388





WO2010/007496





WO2011/022597





WO2011/022608



C-3
Improved photosynthesis
WO 2008/056915





WO 2004/101751



C-4
Nematode resistance
WO 1995/020669





WO 2001/051627





WO 2008/139334





WO 2008/095972





WO 2006/085966





WO 2003/033651





WO 1999/060141





WO 1998/012335





WO 1996/030517





WO 1993/018170





WO2008/095886





WO2008/095887





WO2008/095888





WO2008/095889





WO2008/095910





WO2008/095911





WO2008/095916





WO2008/095919





WO2008/095969





WO2008/095970





WO2008/095972





WO2008/110522





WO2008/139334





WO2008/152008





W02010/077858





WO 2010/091230





WO 2010/102172





WO 2010/106163





WO2011/082217





WO2011/003783





WO2007/146767



C-5
Reduced pod dehiscence
WO 2006/009649





WO 2004/113542





WO 1999/015680





WO 1999/000502





WO 1997/013865





WO 1996/030529





WO 1994/023043



C-6
Aphid resistance
WO 2006/125065





WO 1997/046080





WO 2008/067043





WO 2004/072109





WO2009/091860





WO2010036764



C-7
Sclerotinia resistance
WO 2006/135717





WO 2006/055851





WO 2005/090578





WO 2005/000007





WO 2002/099385





WO 2002/061043



C-8
Botrytis resistance
WO 2006/046861





WO 2002/085105



C-9
Bremia resistance
US 20070022496





WO 2000/063432





WO 2004/049786





WO2009/111627





WO2009/111627



C-10
Erwinia resistance
WO 2004/049786



C-11
Closterovirus resistance
WO 2007/073167





WO 2007/053015





WO 2002/022836



C-12
Stress tolerance (including
WO 2010/019838




drought tolerance)
WO 2009/049110





WO2008/002480





WO2005/033318





WO2008/002480





WO2008/005210





WO2008/006033





WO2008/008779





WO2008/022486





WO2008/025097





WO2008/027534





WO2008/027540





WO2008/037902





WO2008/046069





WO2008/053487





WO2008/057642





WO2008/061240





WO2008/064222





WO2008/064341





WO2008/073617





WO2008/074025





WO2008/076844





WO2008/096138





WO2008/110848





WO2008/116829





WO2008/117537





WO2008/121320





WO2008/125245





WO2008/142034





WO2008/142036





WO2008/145675





WO2008/150165





WO2008/092935





WO2008/145675





WO2009/010460





WO2009/016240





WO2009/031664





WO2009/038581





WO2009/049110





WO2009/053511





WO2009/054735





WO2009/067580





WO2009/068588





WO2009/073605





WO2009/077611





WO2009/079508





WO2009/079529





WO2009/083958





WO2009/086229





WO2009/092009





WO2009/094401





WO2009/094527





WO2009/102965





WO2009/114733





WO2009/117448





WO2009/126359





WO2009/126462





WO2009/129162





WO2009/132057





WO2009/141824





WO2009/148330





WO2010/003917





WO 2010/055024





WO 2010/058428





WO 2010/064934





WO2010/076756





WO 2010/083178





WO 2010/086221





WO 2010/086277





WO 2010/101818





WO 2010/104848





WO 2010/118338





WO 2010/120017





WO 2010/120054





WO 2010/121316





WO 2010/127579





WO 2010/134654





WO 2010/139993





WO2010/039750





WO2011/034968





WO2011/001286





WO2011/017492





WO2011/018662





WO2011/024065





WO2011/038389





WO2011/46772





WO2011/053897





WO2011/052169





WO2011/063706





WO2011/067745





WO2011/079277





WO2011/080674





WO2011/083290





WO2011/083298





WO2011/091764



C-13
Tobamovirus resistance
WO 2006/038794





WO2009086850



C-14
Yield
WO2008/125983





WO2008/015263





WO2008/021021





WO2008/043849





WO2008/044150





WO2008/049183





WO2008/056915





WO2008/059048





WO2008/062049





WO2008/071767





WO2008/074891





WO2008/087932





WO2008/092910





WO2008/092935





WO2008/104598





WO2008/111779





WO2008/122980





WO2008/135206





WO2008/135467





WO2008/135603





WO2008/137108





WO2008/138975





WO2008/142146





WO2008/142163





WO2008/145629





WO2008/145761





WO2008/148872





WO2009//127671





WO2009/065912





WO2009/000789





WO2009/000848





WO2009/000876





WO2009/003977





WO2009/009142





WO2009/012467





WO2009/013225





WO2009/013263





WO2009/014665





WO2009/016104





WO2009/016212





WO2009/016232





WO2009/034188





WO2009/037279





WO2009/037329





WO2009/037338





WO2009/040665





WO2009/056566





WO2009/060040





WO2009/068564





WO2009/072676





WO2009/073069





WO2009/075860





WO2009/077973





WO2009/080743





WO2009/080802





WO2009/091518





WO2009/092772





WO2009/095455





WO2009/095641





WO2009/095881





WO2009/097133





WO2009/106596





WO2009/108513





WO2009/113684





WO2009/134339





WO2009/135130





WO2009/135810





WO2009/145290





WO2009/150170





WO2009/153208





WO2009/156360





WO2010/012796





WO2010/037228





WO2010/000794





WO2010/005298





WO2010/006732





WO2010/007035





WO2010/012760





WO2010/019872





WO2010/023310





WO2010/023320





WO2010/025465





WO2010/025466





WO2010/028205





WO2010/028456





WO2010/033564





WO2010/034652





WO2010/034672





WO2010/034681





WO2010/035784





WO2010/039750





WO2010/046221





WO2010/046471





WO2010/049897





WO2010/055837





WO 2010/065867





WO2010/069847





WO2010/075143





WO2010/075243





WO2010/100595





WO2010/102220





WO2010/104092





WO2010/108836





WO2010/120862





WO2010/123667





WO2010/124953





WO2010/125036





WO2010/127969





WO2010/129501





WO2010/140388





WO2010/140672





WO2011/011273





WO2011/000466





WO2011/003800





WO2011/006717





WO2011/008510





WO2011/009801





WO2011/011412





WO2011/015985





WO2011/020746





WO2011/021190





WO2011/025514





WO2011/025515





WO2011/025516





WO2011/025840





WO2011/031680





WO2011/036160





WO2011/036232





WO2011/041796





WO2011/044254





WO2011/048009





WO2011/053898





WO2011/051120





WO2011/058029





WO2011/061656





WO2011/085062





WO2011/088065



C-15
Oil content/composition
WO 2010/045324





WO 2010/053541





WO 2010/130725





WO 2010/140682





WO2011/006948





WO2011/049627





WO2011/060946





WO2011/062748





WO2011/064181





WO2011/064183





WO2011/075716





WO2011/079005



C-16
Biopharmaceutical production
WO 2010/121818



C-17
Improved recombination
WO2010/071418





WO 2010/133616



C-18
Altered inflorescence
WO 2010/069004



C-19
Disease control (other)
WO 2010/059558





WO2010/075352





WO2010/075498





WO 2010/085289





WO 2010/085295





WO 2010/085373





WO2009/000736





WO2009/065863





WO2009/112505





WO 2010/089374





WO 2010/120452





WO 2010/123904





WO 2010/135782





WO2011/025860





WO2011/041256





WO2011/002992





WO2011/014749





WO2011/031006





WO2011/031922





WO2011/075584





WO2011/075585





WO2011/075586





WO2011/075587





WO2011/075588





WO2011/084622





WO2011/084626





WO2011/084627





WO2011/084629





WO2011/084630





WO2011/084631





WO2011/084314





WO2011/084324





WO2011/023571





WO2011/040880





WO2011/082304





WO2011/003783





WO2011/020797



C-20
Herbicide tolerance
U.S. Pat. No. 4,761,373





U.S. Pat. No. 5,304,732





U.S. Pat. No. 5,331,107





U.S. Pat. No. 5,718,079





U.S. Pat. No. 6,211,438





U.S. Pat. No. 6,211,439





U.S. Pat. No. 6,222,100





US 2003/0217381





US 2003/0217381





WO2004/106529





WO2000/27182





WO2005/20673





WO 2001/85970





U.S. Pat. No. 5,545,822





U.S. Pat. No. 5,736,629





U.S. Pat. No. 5,773,703





U.S. Pat. No. 7,405,347





U.S. Pat. No. 7,504,561





U.S. Pat. No. 7,538,262





U.S. Pat. No. 7,488,866





U.S. Pat. No. 7,534,937





U.S. Pat. No. 7,700,842





U.S. Pat. No. 7,674,958





U.S. Pat. No. 7,910,805





U.S. Pat. No. 7,960,615





U.S. Pat. No. 8,003,854





U.S. Pat. No. 7,834,249





US 2008/0313769





US 2007/0289035





US 2007/0295251









Additional particularly useful plants which may be treated according to the invention with the compound of a compound of formula (I), formula (I-1-1), or formula (I-1-2) or a mixture of two compounds (I-1-1)/(I-1-7), or (I-1-2)/(I-1-8) or a composition comprising a compound of the formula (I) with a further agrochemically active ingredient are plants, containing and expressing a transgenic event according to D1-D48 as listed in Table D.









TABLE D







Non-exhaustive list of characteristics of transgenic plants which may


be treated with a compound of formula (I), formula (I-1-1), or formula


(I-1-2) or a mixture of two compounds (I-1-1)/(I-1-7), or (I-1-2)/(I-1-8) or


a composition comprising a compound of the formula (1) with a further


agrochemically active ingredient according to the invention.











No.
Plant species
Transgenic event
Trait
Patent reference





D-1
Corn
PV-ZMGT32
Glyphosate tolerance
US 2007-056056




(NK603)




D-2
Corn
MIR604
Insect resistance (Cry3a055)
EP 1 737 290


D-3
Corn
LY038
High lysine content
U.S. Pat. No. 7,157,281


D-4
Corn
3272
Self processing corn (alpha-
US 2006-230473





amylase)



D-5
Corn
PV-ZMIR13
Insect resistance (Cry3Bb)
US 2006-095986




(MON863)




D-6
Corn
DAS-59122-7
Insect resistance
US 2006-070139





(Cry34Ab1/Cry35Ab1)



D-7
Corn
TC1507
Insect resistance (Cry1F)
U.S. Pat. No. 7,435,807


D-8
Corn
MON810
Insect resistance (Cry1Ab)
US 2004-180373


D-9
Corn
VIP1034
Insect resistance
WO 03/052073


D-10
Corn
B16
Glufosinate resistance
US 2003-126634


D-11
Corn
GA21
Glyphosate resistance
U.S. Pat. No. 6,040,497


D-12
Corn
GG25
Glyphosate resistance
U.S. Pat. No. 6,040,497


D-13
Corn
GJ11
Glyphosate resistance
U.S. Pat. No. 6,040,497


D-14
Corn
FI117
Glyphosate resistance
U.S. Pat. No. 6,040,497


D-15
Corn
GAT-ZM1
Glufosinate tolerance
WO 01/51654


D-16
Corn
DP-098140-6
Glyphosate tolerance/ALS
WO 2008/112019





inhibitor tolerance



D-17
Wheat
Event 1
Fusarium resistance
CA 2561992





(trichothecene 3-O-






acetyltransferase)



D-18
Sugar beet
T227-1
Glyphosate tolerance
US 2004-117870


D-19
Sugar beet
H7-1
Glyphosate tolerance
WO 2004-074492


D-20
Soybean
MON89788
Glyphosate tolerance
US 2006-282915


D-21
Soybean
A2704-12
Glufosinate tolerance
WO 2006/108674


D-22
Soybean
A5547-35
Glufosinate tolerance
WO 2006/108675


D-23
Soybean
DP-305423-1
High oleic acid/ALS
WO 2008/054747





inhibitor tolerance



D-24
Rice
GAT-OS2
Glufosinate tolerance
WO 01/83818


D-25
Rice
GAT-OS3
Glufosinate tolerance
US 2008-289060


D-26
Rice
PE-7
Insect resistance (Cry1Ac)
WO 2008/114282


D-27
Oilseed rape
MS-B2
Male sterility
WO 01/31042


D-28
Oilseed rape
MS-BN1/RF-BN1
Male sterility/restoration
WO 01/41558


D-29
Oilseed rape
RT73
Glyphosate resistance
WO 02/36831


D-30
Cotton
CE43-67B
Insect resistance (Cry1Ab)
WO 2006/128573


D-31
Cotton
CE46-02A
Insect resistance (Cry1Ab)
WO 2006/128572


D-32
Cotton
CE44-69D
Insect resistance (Cry1Ab)
WO 2006/128571


D-33
Cotton
1143-14A
Insect resistance (Cry1Ab)
WO 2006/128569


D-34
Cotton
1143-51B
Insect resistance (Cry1Ab)
WO 2006/128570


D-35
Cotton
T342-142
Insect resistance (Cry1Ab)
WO 2006/128568


D-36
Cotton
event3006-210-23
Insect resistance (Cry1Ac)
WO 2005/103266


D-37
Cotton
PV-GHGT07
Glyphosate tolerance
US 2004-148666




(1445)




D-38
Cotton
MON88913
Glyphosate tolerance
WO 2004/072235


D-39
Cotton
EE-GH3
Glyphosate tolerance
WO 2007/017186


D-40
Cotton
T304-40
Insect-resistance (Cry1Ab)
WO2008/122406


D-41
Cotton
Cot202
Insect resistance (VIP3)
US 2007-067868


D-42
Cotton
LLcotton25
Glufosinate resistance
WO 2007/017186


D-43
Cotton
EE-GH5
Insect resistance (Cry1Ab)
WO 2008/122406


D-44
Cotton
event 281-24-236
Insect resistance (Cry1F)
WO 2005/103266


D-45
Cotton
Cot102
Insect resistance (Vip3A)
US 2006-130175


D-46
Cotton
MON 15985
Insec resistance
US 2004-250317





(Cry1A/Cry2Ab)



D-47
Bent Grass
Asr-368
Glyphosate tolerance
US 2006-162007


D-48
Brinjal
EE-1
Insect resistance (Cry1Ac)
WO 2007/091277









Additional particularly useful transgenic plants include plants which may be treated according to the invention containing and expressing one or more transgene and are described by the trade name in Table E.









TABLE E







Non-exhaustive lists of transgenic events and its trade names.

















Additional


No.
Trade name
Crop
Company
Genetic Modification
information





E-1
Roundup

Beta vulgaris

Monsanto
Glyphosate tolerance




Ready ®
(sugarbeet)
Company




E-2
InVigor ®

Brassica napus

Bayer
Canola was transformed as





(canola)
CropScience
described:







Ø Expression of a gene







that introduces tolerance to







the herbicide Glyfosinate-







Ammonium;







Ø Introduction of a new







hybridisation system for







canola based on genetically







modified pollen sterility







(MS) and fertility restorer







(RF) lines;







Ø Expression of a gene







introducing antibiotic







resistence



E-3
Liberty

Brassica napus

BayerCropScience
Tolerance to




Link ®
(canola)

Phosphinotricin



E-4
Roundup

Brassica napus

Monsanto
Glyphosate tolerance




Ready ®
(canola)
Company




E-5
Clearfield ®

Brassica napus

BASF
Non-GM, tolerance to





(canola)
Corporation
Imazamox



E-6
Optimum ™

Glycine max

Pioneer Hi-
Glyphosate and ALS-




GAT ™
L. (soybean)
Bred
inhibitor tolerance






International,







Inc




E-7
Roundup

Glycine max

Monsanto
Glyphosate tolerance




Ready ®
L. (soybean)
Company




E-8
Roundup

Glycine max

Monsanto
Glyphosate tolerance




RReady2Yiel ™
L. (soybean)
Company




E-9
STS ®

Glycine max

DuPont
Tolerance to Sulfonyl





L. (soybean)

ureas



E-10
YIELD

Glycine max

Monsanto





GARD ®
L. (soybean)
Company




E-11
AFD ®

Gossypium

Bayer
The following lines belong






hirsutum

CropScience
to AFD ®: AFD5062LL,





L. (cotton)

AFD5064F, AFD5065B2F;







AFD seeds are







available for different







varieties/cultivars with







integrated technology, for







example technologies like







Bollgard ®, Bollgard II,







Roundup Ready, Roundup







Ready Flex and







LibertyLink ®



E-12
Bollgard II ®

Gossypium

Monsanto
MON 15985-Event:






hirsutum

Company
Cry2(A)b1; Cry1A(c)





L. (cotton)





E-13
Bollgard ®

Gossypium

Monsanto
Cry 1Ac






hirsutum

Company






L. (cotton)





E-14
FiberMax ®

Gossypium

Bayer







hirsutum

CropScience






L. (cotton)





E-15
Liberty

Gossypium

Bayer
Tolerance to




Link ®

hirsutum

CropScience
Phosphinotricin





L. (cotton)





E-16
Nucotn 33B

Gossypium

Delta Pine and
Bt toxin in






hirsutum

Land
varieties/cultivars of Delta





L. (cotton)

Pine: CrylAc



E-17
Nucotn 35B

Gossypium

Delta Pine and
Bt toxin in






hirsutum

Land
varieties/cultivars of Delta





L. (cotton)

Pine: CrylAc



E-18
Nucotn ®

Gossypium

Delta Pine and
Bt toxin in






hirsutum

Land
varieties/cultivars of Delta





L. (cotton)

Pine



E-19
PhytoGen ™

Gossypium

PhytoGen
Includes varieties/cultivars






hirsutum

Seed
which contain for example





L. (cotton)
Company,
Roundup Ready flex,






Dow
Widestrike






AgroSciences







LLC




E-20
Roundup

Gossypium

Monsanto
Glyphosate tolerance




Ready Flex ®

hirsutum

Company






L. (cotton)





E-21
Roundup

Gossypium

Monsanto
Glyphosate tolerance




Ready ®

hirsutum

Company






L. (cotton)





E-22
Widestrike ™

Gossypium

Dow
Cry1F and Cry1Ac
Monsanto/Dow





hirsutum

AgroSciences






L. (cotton)
LLC




E-23
YIELD

Gossypium

Monsanto

http://www.garstseed.com/GarstClient/Technology/



GARD ®

hirsutum

Company

agrisure.aspx




L. (cotton)





E-24
Roundup

Medicago

Monsanto
Glyphosate tolerance




Ready ®

sativa (alfalfa)
Company




E-25
Clearfield ®

Oryza sativa

BASF
Non-GM, tolerance to





(rice)
Corporation
Imazamox



E-26
NewLeaf ®

Solanum

Monsanto
Resistance against infection






tuberosum

Company
with potato leaf roll virus





L. (potato)

(PLRV) and damage caused







by the potato beetle








Leptinotarsa decemlineata




E-27
NewLeaf ®

Solanum

Monsanto
Resistance against infection
http://www.dowagro.com/phytogen/index.htm



plus

tuberosum

Company
with potato leaf roll virus





L. (potato)

(PLRV) and damage caused







by the potato beetle








Leptinotarsa decemlineata




E-28
Protecta ®

Solanum









tuberosum








L. (potato)





E-29
Clearfield ®
Sunflower
BASF
Non-GM, tolerance to






Corporation
Imazamox



E-30
Roundup

Triticum

Monsanto
Glyphosate tolerance




Ready ®

aestivum

Company
NK603





(wheat)





E-31
Clearfield ®

Triticum

BASF
Non-GM, tolerance to






aestivum

Corporation
Imazamox





(wheat)





E-32
Agrisure ®

Zea mays

Syngenta
comprises Agrisure CB/LL




(Familie)
L. (corn)
Seeds, Inc.
(BT 11 event plus







Phosphinotricin tolerance







mediated by GA21 event);







Agrisure CB/LL/RW (Bt 11







event, modified synthetic







cry3A gene,







Phosphinotricin tolerance







mediated by GA21 event);







Agrisure GT (Glyphosate







tolerance); Agrisure







GT/CB/LL(Glyphosate and







tolerance Phosphinotricin







tolerance mediated by







GA21 event, Bt 11 event);







Agrisure 3000GT







(CB/LL/RW/GT:







Glyphosate and tolerance







Phosphinotricin tolerance







mediated by GA21 event,







Bt 11 event, modified







synthetic cry3A gene);







Agrisure GT/RW







(Glyphosate tolerance,







modified synthetic cry3A







gene); Agrisure RW







(modified synthetic cry3A







gene); future traits



E-33
BiteGard ®

Zea mays

Novartis
cry1A(b) gene





L. (corn)
Seeds




E-34
Bt-Xtra ®

Zea mays

DEKALB
cry1Ac gene





L. (corn)
Genetics







Corporation




E-35
Clearfield ®

Zea mays

BASF
Non-GM, tolerance to





L. (corn)
Corporation
Imazamox



E-36
Herculex ®

Zea mays

Dow





(Familie)
L. (corn)
AgroSciences







LLC




E-37
IMI ®

Zea mays

DuPont
Toleranz fur Imidazolinone





L. (corn)





E-38
KnockOut ®

Zea mays

Syngenta
SYN-EV176-9: cry1A(b)-





L. (corn)
Seeds, Inc.
Gen.



E-39
Mavera ®

Zea mays

Renessen LLC
Lysine rich
http://www.dowagro.com/widestrike/




L. (corn)





E-40
NatureGard ®

Zea mays

Mycogen
cry1A(b) gene





L. (corn)





E-41
Roundup

Zea mays

Monsanto
Glyphosate tolerance
http://www.starlinkcorn.com/starlinkcorn.htm



Ready ®
L. (corn)
Company




E-42
Roundup

Zea mays

Monsanto
Glyphosate tolerance




Ready ® 2
L. (corn)
Company




E-43
SmartStax

Zea mays

Monsanto
Combination of eight genes





L. (corn)
Company




E-44
StarLink ®

Zea mays

Aventis
Cry9c gene





L. (corn)
CropScience







->Bayer







CropScience




E-45
STS ®

Zea mays

DuPont
Tolerance to Sulfonyl ureas





L. (corn)





E-46
YIELD

Zea mays

Monanto
Mon810, Cry1Ab1;
http://www.dowagro.com/herculex/about/herculexfamily/



GARD ®
L. (corn)
Company
Resistance against







European corn borer



E-47
YieldGard ®

Zea mays

Monsanto
Mon810×Mon863, double




Plus
L. (corn)
Company
stack, resistance against







European corn borer and







Western corn rootworm



E-48
YieldGard ®

Zea mays

Monsanto
Mon863, Cry3Bb1,




Rootworm
L. (corn)
Company
resistance against Western







corn rootworm



E-49
YieldGard ®

Zea mays

Monsanto
Combination of several




VT
L. (corn)
Company
traits



E-50
YieldMaker ™

Zea mays

DEKALB
contains Roundup Ready 2-





L. (corn)
Genetics
Technology, YieldGard






Corporation
VT, YieldGard Corn Borer,







YieldGard Rootworm and







YieldGard Plus









Additional particularly useful plants which may be treated according to the invention with a compound of the formula (I), formula (I-1-1), or formula (I-1-2) or a mixture of two compounds (I-1-1)/(I-1-7), or (I-1-2)/(I-1-8) or a composition comprising a compound of the formula (I) with a further agrochemically active ingredient are plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) that contain multi stacks (alternative: combination) of one or more insect control traits and/or one or more nematode control traits and/or one or more herbicide tolerance/resistance traits and/or one or more disease control traits and/or one or more yield increasing traits and/or one or more quality altering traits and/or one or more abiotic stress traits.


Additional particularly useful plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated with a compound of the formula (I), formula (I-1-1), or formula (I-1-2) or a mixture of two compounds (I-1-1)/(I-1-7), or (I-1-2)/(I-1-8) or a composition comprising a compound of the formula (I), formula (I-1-1), or formula (I-1-2) or a mixture of two compounds (I-1-1)/(I-1-7), or (I-1-2)/(I-1-8) with a further agrochemically active ingredient according to the invention are plants that contain multi stacks (alternative: combination) of one or more insect control traits and/or one or more nematode control traits and/or one or more herbicide tolerance/resistance traits and/or one or more yield increasing traits and/or one or more abiotic stress traits.


Additional particularly useful plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated with a compound of the formula (I), formula (I-1-1), or formula (I-1-2) or a mixture of two compounds (I-1-1)/(I-1-7), or (I-1-2)/(I-1-8) or a composition comprising a compound of the formula (I) with a further agrochemically active ingredient according to the invention are plants that contain multi stacks (alternative: combination) of one or more insect control traits and/or one or more nematode control traits and/or one or more herbicide tolerance/resistance traits and/or one or more yield increasing traits.


Additional particularly useful plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated with a compound of the formula (I), formula (I-1-1), or formula (I-1-2) or a mixture of two compounds (I-1-1)/(I-1-7), or (I-1-2)/(I-1-8) or a composition comprising a compound of the formula (I) with a further agrochemically active ingredient according to the invention are plants that contain multi stacks (alternative: combination) of one or more insect control traits and/or one or more nematode control traits and/or one or more herbicide tolerance/resistance traits and/or one or more abiotic stress traits.


Additional particularly useful plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated with a compound of the formula (I), formula (I-1-1), or formula (I-1-2) or a mixture of two compounds (I-1-1)/(I-1-7), or (I-1-2)/(I-1-8) or a composition comprising a compound of the formula (I) with a further agrochemically active ingredient according to the invention are plants that contain multi stacks (alternative: combination) of one or more insect control traits and/or one or more nematode control traits and/or one or more herbicide tolerance/resistance traits.


Formulations


The present invention further provides formulations, and application forms prepared from them, as crop protection agents and/or pesticidal agents, such as drench, drip and spray liquors, comprising at least one of the active compounds of the invention. The application forms may comprise further crop protection agents and/or pesticidal agents, and/or activity-enhancing adjuvants such as penetrants, examples being vegetable oils such as, for example, rapeseed oil, sunflower oil, mineral oils such as, for example, liquid paraffins, alkyl esters of vegetable fatty acids, such as rapeseed oil or soybean oil methyl esters, or alkanol alkoxylates, and/or spreaders such as, for example, alkylsiloxanes and/or salts, examples being organic or inorganic ammonium or phosphonium salts, examples being ammonium sulphate or diammonium hydrogen phosphate, and/or retention promoters such as dioctyl sulphosuccinate or hydroxypropylguar polymers and/or humectants such as glycerol and/or fertilizers such as ammonium, potassium or phosphorous fertilizers, for example.


Examples of typical formulations include water-soluble liquids (SL), emulsifiable concentrates (EC), emulsions in water (EW), suspension concentrates (SC, SE, FS, OD), water-dispersible granules (WG), granules (GR) and capsule concentrates (CS); these and other possible types of formulation are described, for example, by Crop Life International and in Pesticide Specifications, Manual on development and use of FAO and WHO specifications for pesticides, FAO Plant Production and Protection Papers—173, prepared by the FAO/WHO Joint Meeting on Pesticide Specifications, 2004, ISBN: 9251048576. The formulations may comprise active agrochemical compounds other than one or more active compounds of the invention.


The formulations or application forms in question preferably comprise auxiliaries, such as extenders, solvents, spontaneity promoters, carriers, emulsifiers, dispersants, frost protectants, biocides, thickeners and/or other auxiliaries, such as adjuvants, for example. An adjuvant in this context is a component which enhances the biological effect of the formulation, without the component itself having a biological effect. Examples of adjuvants are agents which promote the retention, spreading, attachment to the leaf surface, or penetration.


These formulations are produced in a known manner, for example by mixing the active compounds with auxiliaries such as, for example, extenders, solvents and/or solid carriers and/or further auxiliaries, such as, for example, surfactants. The formulations are prepared either in suitable plants or else before or during the application.


Suitable for use as auxiliaries are substances which are suitable for imparting to the formulation of the active compound or the application forms prepared from these formulations (such as, e.g., usable crop protection agents, such as spray liquors or seed dressings) particular properties such as certain physical, technical and/or biological properties.


Suitable extenders are, for example, water, polar and nonpolar organic chemical liquids, for example from the classes of the aromatic and non-aromatic hydrocarbons (such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), the alcohols and polyols (which, if appropriate, may also be substituted, etherified and/or esterified), the ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly)ethers, the unsubstituted and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, the sulphones and sulphoxides (such as dimethyl sulphoxide).


If the extender used is water, it is also possible to employ, for example, organic solvents as auxiliary solvents. Essentially, suitable liquid solvents are: aromatics such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, for example petroleum fractions, mineral and vegetable oils, alcohols such as butanol or glycol and also their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethylformamide and dimethyl sulphoxide, and also water.


In principle it is possible to use all suitable solvents. Suitable solvents are, for example, aromatic hydrocarbons, such as xylene, toluene or alkylnaphthalenes, for example, chlorinated aromatic or aliphatic hydrocarbons, such as chlorobenzene, chloroethylene or methylene chloride, for example, aliphatic hydrocarbons, such as cyclohexane, for example, paraffins, petroleum fractions, mineral and vegetable oils, alcohols, such as methanol, ethanol, isopropanol, butanol or glycol, for example, and also their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, for example, strongly polar solvents, such as dimethyl sulphoxide, and water.


All suitable carriers may in principle be used. Suitable carriers are in particular: for example, ammonium salts and ground natural minerals such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals, such as finely divided silica, alumina and natural or synthetic silicates, resins, waxes and/or solid fertilizers. Mixtures of such carriers may likewise be used. Carriers suitable for granules include the following: for example, crushed and fractionated natural minerals such as calcite, marble, pumice, sepiolite, dolomite, and also synthetic granules of inorganic and organic meals, and also granules of organic material such as sawdust, paper, coconut shells, maize cobs and tobacco stalks.


Liquefied gaseous extenders or solvents may also be used. Particularly suitable are those extenders or carriers which at standard temperature and under standard pressure are gaseous, examples being aerosol propellants, such as halogenated hydrocarbons, and also butane, propane, nitrogen and carbon dioxide.


Examples of emulsifiers and/or foam-formers, dispersants or wetting agents having ionic or nonionic properties, or mixtures of these surface-active substances, are salts of polyacrylic acid, salts of lignosulphonic acid, salts of phenolsulphonic acid or naphthalenesulphonic acid, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, with substituted phenols (preferably alkylphenols or arylphenols), salts of sulphosuccinic esters, taurine derivatives (preferably alkyltaurates), phosphoric esters of polyethoxylated alcohols or phenols, fatty acid esters of polyols, and derivatives of the compounds containing sulphates, sulphonates and phosphates, examples being alkylaryl polyglycol ethers, alkylsulphonates, alkyl sulphates, arylsulphonates, protein hydrolysates, lignin-sulphite waste liquors and methylcellulose. The presence of a surface-active substance is advantageous if one of the active compounds and/or one of the inert carriers is not soluble in water and if application takes place in water.


Further auxiliaries that may be present in the formulations and in the application forms derived from them include colorants such as inorganic pigments, examples being iron oxide, titanium oxide, Prussian Blue, and organic dyes, such as alizarin dyes, azo dyes and metal phthalocyanine dyes, and nutrients and trace nutrients, such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.


Stabilizers, such as low-temperature stabilizers, preservatives, antioxidants, light stabilizers or other agents which improve chemical and/or physical stability may also be present. Additionally present may be foam-formers or defoamers.


Furthermore, the formulations and application forms derived from them may also comprise, as additional auxiliaries, stickers such as carboxymethylcellulose, natural and synthetic polymers in powder, granule or latex form, such as gum arabic, polyvinyl alcohol, polyvinyl acetate, and also natural phospholipids, such as cephalins and lecithins, and synthetic phospholipids. Further possible auxiliaries include mineral and vegetable oils.


There may possibly be further auxiliaries present in the formulations and the application forms derived from them. Examples of such additives include fragrances, protective colloids, binders, adhesives, thickeners, thixotropic substances, penetrants, retention promoters, stabilizers, sequestrants, complexing agents, humectants and spreaders. Generally speaking, the active compounds may be combined with any solid or liquid additive commonly used for formulation purposes.


Suitable retention promoters include all those substances which reduce the dynamic surface tension, such as dioctyl sulphosuccinate, or increase the viscoelasticity, such as hydroxypropylguar polymers, for example.


Suitable penetrants in the present context include all those substances which are typically used in order to enhance the penetration of active agrochemical compounds into plants. Penetrants in this context are defined in that, from the (generally aqueous) application liquor and/or from the spray coating, they are able to penetrate the cuticle of the plant and thereby increase the mobility of the active compounds in the cuticle. This property can be determined using the method described in the literature (Baur et al., 1997, Pesticide Science 51, 131-152). Examples include alcohol alkoxylates such as coconut fatty ethoxylate (10) or isotridecyl ethoxylate (12), fatty acid esters such as rapeseed or soybean oil methyl esters, fatty amine alkoxylates such as tallowamine ethoxylate (15), or ammonium and/or phosphonium salts such as ammonium sulphate or diammonium hydrogen phosphate, for example.


The formulations preferably comprise between 0.00000001% and 98% by weight of active compound or, with particular preference, between 0.01% and 95% by weight of active compound, more preferably between 0.5% and 90% by weight of active compound, based on the weight of the formulation.


The active compound content of the application forms (crop protection products) prepared from the formulations may vary within wide ranges. The active compound concentration of the application forms may be situated typically between 0.00000001% and 95% by weight of active compound, preferably between 0.00001% and 1% by weight, based on the weight of the application form.


In the compositions according to the invention the ratio of a compound of the formula (I) to an agrochemically active compound of group (B) can be varied within a relatively wide range. In general, the inventive combinations comprise active ingredients of the formula (I) to the mixing partner from group (II) in a ratio of 625:1 to 1:625; preferably in a ratio of 125:1 to 1.125, more preferably in a ratio of 25:1 to 1:25, even more preferably in a ratio of 5:1 to 1:5.


Application Methods


The treatment according to the invention of the plants and plant parts with a compound of the formula (I) or compositions is carried out directly or by action on their surroundings, habitat or storage space using customary treatment methods, for example by dipping, spraying, atomizing, irrigating, stem injection, in-furrow application, evaporating, dusting, fogging, broadcasting, foaming, painting, spreading-on, watering (drenching), drip irrigating and, in the case of propagation material, in particular in the case of seeds, furthermore as a powder for dry seed treatment, a solution for seed treatment, a water-soluble powder for slurry treatment, by incrusting, by coating with one or more layers, etc. It is furthermore possible to apply the active compounds by the ultra-low volume method, or to inject the active compound preparation or the active compound itself into the soil.


Generally, a compound of the formula (I) is applied in a rate of 1 g to 20 kg per ha, preferably 5 g to 5 kg per ha, most preferably 10 g to 1 kg per ha.


EXAMPLES
Formula for the Efficacy of the Combination of Two Compounds

The expected efficacy of a given combination of two compounds is calculated as follows (see Colby, S. R., “Calculating Synergistic and antagonistic Responses of Herbicide Combinations”, Weeds 15, pp. 20-22, 1967):


if

    • X is the efficacy expressed in % mortality of insects on the control plants treated with compound A at a concentration of m ppm or m g/ha,
    • Y is the efficacy expressed in % mortality of insects on the untreated transgenic plant expressing one or more insect-controlling transgenes
    • E is the efficacy expressed in % mortality of insects on the transgenic plant expressing one or more insect-controlling transgenes and being treated with compound A
    • then is






E
=

X
+
Y
-



X
·
Y

100

.






If the observed insecticidal efficacy of the combination is higher than the one calculated as “E”, then the combination of the two compounds is more than additive, i.e., there is a synergistic effect.


Example 1

Nilaparvata lugens on Transgenic Rice (Oryza sativa)
















Solvent:
7 parts by weight of dimethylformamide



Emulsifier:
2 parts by weight of alkylaryl polyglycolether









To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvent and emulsifier, and the concentrate is diluted with emulsifier-containing water to the desired concentration.


Pots with transgenic rice plants containing insect resistance and herbicide resistance genes and non-transgenic control plants are treated in 2 replicates by being sprayed with the preparation of the active compound of the desired concentration and infested with larvae of the brown plant hopper (Nilaparvata lugens).


After the specified period of time, the mortality in % is determined. 100% means that all the larvae have been killed; 0% means that none of the larvae have been killed.


The results obtained were compared to the results of the compound on non-transgenic rice plants and the results of the non-treated transgenic rice plants.









TABLE 1








Nilaparvata lugens on rice










Concentration
Mortality


Active Compound
in ppm
in % after 2 d












Compound (I-1-1)/(I-1-7) on non-
100
20


transgenic rice




rice containing plant expressible
—
0


Cry1Ab, Cry1C genes














obs*
cal.**


Compound (I-1-1)/(I-1-7) on rice
100
100
20


containing plant expressible Cry1Ab,





Cry1C genes





According to the invention





*obs. = observed insecticidal efficacy,


**cal. = efficacy calculated with Colby-formula






Example 2


Zea Mays (Corn) seed from events traited with Axmi205 were selected. Axmi205 historically shows efficacy against Diabrotica virgifera (western corn rootworm). The population of the seed used is not entirely transgenic; plants without the trait in their DNA were used for control comparisons.


Seed was treated with seed applied compound (I-1-1/I-1-7) using a hege bowl treater. Rates were applied as mg ai/seed. Each chemical evaluation was handled as a separate trial and had non-target variables controlled.


During testing, samples of each plant were submitted for PCR to determine if an individual plant carried the Axmi205 gene (positive or negative). Plants for which no PCR results could be obtained were not included in the results.


Seed were planted into germination mix at a rate of one seed per root-trainer. Testing was conducted as a randomized complete block with 30 replications. Plants were maintained in a greenhouse and periodically assessed for emergence. After approximately three weeks from planting, plants were infested with Diabrotica virgifera (western corn rootworm). Western corn rootworm eggs were infested into the root system of plants. At approximately 15 days post infestation plants were extracted and insect feeding damage was evaluated following Iowa State University's Node-Injury Scale at www.ent.iastate.edu/pest/rootworm/nodeinjury/nodeinjury.html.


The trait Axmi205 is known to have efficacy on western corn rootworm (D. virgifera). Compound (I-1-1)/(I-1-7) is an experimental insecticide. Witnessed root damage in the controls was lower than that of seed treated with the lowest rate of Compound (I-1-1)/(I-1-7). This could be due to lower pressure in the control due to variation within pest establishment. Compound (I-1-1)/(I-1-7) as an individual component appeared to present little efficacy against western corn rootworm. However, examining Compound (I-1-1)/(I-1-7) at a rate of 0.125 mg ai/seed there was a 26% reduction in root feeding damage in the presences of Axmi205. At the highest rate of Compound (I-1-1)/(I-1-7) the reduction increases to 32%. The addition of Compound (I-1-1)/(I-1-7) at a rate of 0.5 mg ai/seed to Axmi205 also resulted in a 32% reduction of root damage, while the addition of Compound (I-1-1)/(I-1-7) to negative seed did not consistently result in reduced damage. At the highest rate of Compound (I-1-1)/(I-1-7)), the presence of Amxi205 reduced root damage by more than one would expect from Axmi205 alone (11% to 32%). See Table 2.












TABLE 2








Insect



PCR
Plant Emergence
Efficacy





















Trait
Axmi205
Axmi205
Axmi205
Axmi205
Axmi205
Axmi205


Target
Corn
Corn
Corn
Corn
Corn

D.
virgifera



Criteria
Negative or
Emerged
Emerged
Emerged
Emerged
Root Damage



Positive




Rating


Trt/Date
7/19/2011
7/10/2011
7/11/2011
7/12/2011
7/14/2011
8/23/2011


UTC**
Negative 11
 7%
37%
37%
37%
0.89



plants







UTC + Axmi205
Positive 18
 7%
60%
60%
60%
0.79



plants







COMPOUND
Negative 12
 0%
40%
40%
40%
1.56


(I-1-1)/(I-1-7)
plants







@ 0.125 mg








ai/seed + Axmi205








COMPOUND
Positive 17
 0%
57%
57%
57%
1.16


(I-1-1)/(I-1-7)
plants







@ 0.125 mg








ai/seed + Axmi205








COMPOUND
Negative 18
17%
60%
60%
60%
0.88


(I-1-1)/(I-1-7)
plants







@ 0 .25 mg








ai/seed








COMPOUND
Positive 12
 0%
40%
40%
40%
0.75


(I-1-1)/(I-1-7)
plants







@ 0.25 mg








ai/seed + Axmi205








COMPOUND
Negative 18
13%
53%
57%
60%
0.79


(I-1-1)/(I-1-7)
plants







@ 0.5 mg








ai/seed








COMPOUND
Positive 12
 7%
40%
40%
40%
0.54


(I-1-1)/(I-1-7)
plants







@ 0.5 + Axmi205








mg ai/seed





*Root Damage Rating 0 = undamaged; 3 = severely damaged


**UTC = untreated control; plants were infested with WCRW but not treated with compound (I-1-1)/(I-1-7)






Example 3

Nezara viridula on Transgenic Soybean (Glycine max)
















Solvent:
7 parts by weight of dimethylformamide



Emulsifier:
2 parts by weight of alkylaryl polyglycolether









To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvent and emulsifier, and the concentrate is diluted with emulsifier-containing water to the desired concentration.


Seeds of the transgenic Glycine max line MON89788 deposited at the American Type Culture Collection (ATCC) were obtained under the number ATCC-PTA-6708 from LGC Standards GmbH, Mercatorstr. 51, 46485 Wesel, Germany. The MON89788 line is described in the US patent application US 2006/0282915 and contains a Glyphosate tolerance mediating 5-enol-pyruvyl shikimate-3-phosphate synthase gene derived from Agrobacterium sp. Strain CP4 (CP4 EPSPS). The Glyphosate tolerance of plants was confirmed by dipping a leaf into Roundup® UltraMax (Monsanto) solution (0.75%).


Single potted non-transgenic and transgenic soybean plants are treated in 2 replicates by being sprayed with the preparation of the active compound of the desired concentration and infested with larvae of the southern green stink bug (Nezara viridula).


After the specified period of time, the mortality in % is determined. 100% means that all the larvae have been killed; 0% means that none of the larvae have been killed.


The results obtained were compared to the results of the compound on non-transgenic soybean plants and the results of the non-treated transgenic soybean plants.









TABLE 3








Nezara viridula on soybean (Glycine max)










Concentration
Mortality


Active Compound
in ppm
in % after 2 d












Compound (I-1-1)/(I-1-7) on non-
20
17


transgenic soybean




MON89788 soybean
—
0












obs*
cal.**


Compound (I-1-1)/(I-1-7) on
20
50
17


MON89788 soybean





According to the invention





*obs. = observed insecticidal efficacy,


**cal. = efficacy calculated with Colby-formula






Example 4

Spodoptera frugiperda on Transgenic Maize (Zea mays)
















Solvent:
7 parts by weight of dimethylformamide



Emulsifier:
2 parts by weight of alkylaryl polyglycolether









To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvent and emulsifier, and the concentrate is diluted with emulsifier-containing water to the desired concentration.


Seeds of the transgenic Zea mays line GA21 deposited at the American Type Culture Collection (ATCC) were obtained under the number ATCC-209033 from LGC Standards GmbH, Mercatorstr. 51, 46485 Wesel, Germany. The Ga21 line is described in the U.S. Pat. No. 6,040,497 and contains a modified 5-enol-pyruvyl shikimate-3-phosphate synthase gene (mEPSPS) of Zea mays conferring glyphosate tolerance. The Glyphosate tolerance of plants was confirmed by dipping a leaf into Roundup® UltraMax (Monsanto) solution (0.75%).


Single potted non-transgenic or transgenic maize plants are treated in 2 replicates by being sprayed with the preparation of the active compound of the desired concentration and are infested with caterpillars of the fall army worm (Spodoptera frugiperda).


After the specified period of time, the mortality in % is determined. 100% means that all the caterpillars have been killed; 0% means that none of the caterpillars have been killed.


The results obtained were compared to the results of the compound on non-transgenic maize plants and the results of the non-treated transgenic maize plants.









TABLE 4








Spodoptera frugiperda on maize










Concentration
Mortality


Active Compound
in ppm
in % after 3 d





Compound (I-1-1)/(I-1-7) on non-
0.16
80


transgenic maize




GA21 maize (mEPSPS)
—
10












obs*
cal.**


Compound (I-1-1)/(I-1-7) on GA21
0.16
100
82


maize





According to the invention





*obs. = observed insecticidal efficacy,


**cal. = efficacy calculated with Colby-formula





Claims
  • 1. A method for controlling insects, and/or acarids and/or nematodes comprising applying a mixture of compounds
  • 2. A method for controlling insects and/or acarids and/or nematodes according to claim 1, comprising applying a composition comprising A) the mixture of compounds andB) one or more additional agrochemically active compounds.
  • 3. The method according to claim 1, wherein the compounds are at a rate of 5 g to 5 kg per ha.
  • 4. The method for controlling insects, and/or acarids and/or nematodes according to claim 1, comprising applying the compounds on seeds of one or more transgenic crops.
  • 5. The method of for controlling insects, and/or acarids and/or nematodes according to claim 1, comprising applying the compounds to one or more of transgenic corn, soybean, cotton, rice, oilseed rape, sugar cane, sugar beet, potatoes, vegetables, tomatoes, curcurbits, tobacco, coffee, and fruits.
  • 6. The method according to claim 1, which increases yield.
  • 7. The method according to claim 1, wherein the crop is transgenic corn.
  • 8. The method according to claim 1, wherein the crop is transgenic soybean.
  • 9. The method according to claim 1, wherein the crop is transgenic rice.
CROSS REFERENCE TO RELATED APPLICATIONS

This application is a §371 National Stage Application of PCT/EP2012/075844, filed Dec. 17, 2012, which claims priority to U.S. Provisional Application 61/577,233, filed Dec. 19, 2011.

PCT Information
Filing Document Filing Date Country Kind
PCT/EP2012/075844 12/17/2012 WO 00
Publishing Document Publishing Date Country Kind
WO2013/092519 6/27/2013 WO A
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Entry
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Related Publications (1)
Number Date Country
20140329676 A1 Nov 2014 US
Provisional Applications (1)
Number Date Country
61577233 Dec 2011 US