USE OF BENZO-FUSED HETEROCYLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MIGRAINE

Abstract

The present invention is a method for the treatment or prevention of migraine comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as herein defined. The present invention is directed to a method for the treatment and/or prevention of migraine, which includes mono-therapy and alternatively, co-therapy with at least anti-migraine agent.

Description

Claims

1. A method of treating migraine comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula (I)

2. The method as in claim 1, wherein R1 and R2 are each independently selected from the group consisting of hydrogen and lower alkyl;R4 is selected from the group consisting of hydrogen and lower alkyl;a is an integer from 1 to 2;

3. The method as in claim 2, wherein R1 and R2 are each independently selected from the group consisting of hydrogen and lower alkyl;R4 is selected from the group consisting of hydrogen and lower alkyl;a is an integer from 1 to 2;

4. The method as in claim 3, wherein R1 and R2 are each independently selected from the group consisting of hydrogen and lower alkyl;R4 is selected from the group consisting of hydrogen and methyl;a is an integer from 1 to 2;

5. The method as in claim 4, wherein R1 and R2 are each independently selected from the group consisting of hydrogen and methyl;R4 is selected from the group consisting of hydrogen and methyl;a is an integer from 1 to 2;

6. The method of claim 1, wherein the compound of formula (I) is selected from the group consisting of (2S)-(−)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide; and pharmaceutically acceptable salts thereof.

7. A method of treating migraine comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting (2S)-(−)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide; and pharmaceutically acceptable salts thereof.

8. A method of treating migraine comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula (II)