Claims
- 1. A method for inhibiting the growth of cancerous and precancerous cell populations comprising the step of applying a therapeutic amount of eugenol and 2ME in combination to a cancerous or pre-cancerous prostate cell population for a sufficient time to observe arrest of growth of said population.
- 2. A therapeutic agent useful in the prevention and treatment of prostate cancerous tumors comprising therapeutic dossages of eugenol and 2-methoxyestradiol in combination.
- 3. A method of inducing apoptosis in cancerous tissues comprising the steps of:administering a therapeutic dosage of a composition containing 2-methoxyestradiol and eugenol in combination to a cancerous or pre-cancerous prostate tissues, said administration continuing at least until the initiation of cell apoptosis in said cancerous tissues.
- 4. A method for arresting growth of cancer tissues comprising the steps of:administering a therapeutic dosage of a composition containing 2-methoxyestradiol and eugenol in combination to a cancerous or pre-cancerous prostate tissue, said administration occurring at a time wbich, at least for some cells in said cancerous tissue, precedes cell division in the G2/M phase.
CITATION TO PRIOR APPLICATION
This is a continuation-in-part with respect to U.S. application Ser. No. 09/527,283, filed Mar. 17, 2000, now abandoned, from which priority is claimed under 35 U.S.C. §120 and under provisions of the Patent Cooperation Treaty. This is also a continuation-in-part with respect to U.S. application Ser. No. 09/777,151, filed Feb. 5, 2001, which is also a continuation in part of U.S. application Ser. No. 09/527,283, filed Mar. 17, 2000.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5958892 |
Mukhopadhyay et al. |
Sep 1999 |
A |
6136992 |
Ram et al. |
Oct 2000 |
A |
Foreign Referenced Citations (2)
Number |
Date |
Country |
9630012 |
Oct 1996 |
WO |
9922728 |
May 1999 |
WO |
Non-Patent Literature Citations (1)
Entry |
Sukumaran et al., “Inhibition of tumor promotion in mice by eugenol”. Indian J. Physiol. Pharmacol., vol. 38(4), pp. 306-308, 1994. |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
09/527283 |
Mar 2000 |
US |
Child |
09/780269 |
|
US |
Parent |
09/777151 |
Feb 2001 |
US |
Child |
09/527283 |
|
US |