Claims
- 1. A method of treating depression in a patient, which method comprises administering to a patient in need thereof an effective amount of a compound having the formula I (c): ##STR14## wherein: R.sup.1c and R.sup.2c, together with the carbon atoms to which they are attached, represent an unsubstituted phenyl ring fused to the isoxazole ring or a substituted phenyl ring fused to the isoxazole ring, said substituted phenyl ring having as a substituent at least one substituent selected group, a C.sub.1 -C.sub.3 alkoxy group, a hydroxy group, a halogen atom, a nitro group, an amino group and a C.sub.2 -C.sub.4 aliphatic carboxylic acylamino group; and
- R.sup.3c, R.sup.4c and the nitrogen atom to which they are attached together represent an alicyclic amino group having a total of 5 or 6 ring atoms, of which one ring atom is said nitrogen atom and one ring atom is optionally an additional heteroatom selected from the group consisting of nitrogen, oxygen and sulfur, said alicyclic amino group being unsubstituted or, where there is an additional nitrogen heteroatom, said alicyclic amino group having a substituent of a C.sub.1 -C.sub.3 alkyl group on said additional nitrogen heteroatom;
- or a pharmacologically acceptable acid addition salt thereof.
- 2. The method according to claim 1, wherein R.sup.1c and R.sup.2c is an unsubstituted or substituted phenyl ring fused to the isoxazole ring, wherein said substituted phenyl ring is substituted by a substituent selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, fluorine, chlorine, bromine, nitro, amino, acetylamino and propionylamino; and R.sup.3c, R.sup.4c and the nitrogen atom which they are attached together form an alicyclic amino group selected from the group consisting of morpholino, 1-piperazinyl, 4-methyl-1-piperazinyl, 1-pyrrolidinyl and piperidino.
Priority Claims (3)
Number |
Date |
Country |
Kind |
1-162940 |
Jun 1989 |
JPX |
|
1-215607 |
Aug 1989 |
JPX |
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1-264706 |
Oct 1989 |
JPX |
|
Parent Case Info
This is a division of application Ser. No. 07/537,517 filed Jun. 13, 1990, now U.S. Pat. No. 5,116,839.
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Jul 1989 |
|
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Non-Patent Literature Citations (3)
Entry |
Patent Abstracts of Japan, vol. 12, No. 467 (C-550) [3314], Dec. 7, 1988 of JP-A-63-188625 (Mitsui Toatsu Chem. Inc.) Apr. 8, 1988, Japan. |
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Divisions (1)
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Number |
Date |
Country |
Parent |
537517 |
Jun 1990 |
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