Claims
- 1. A method of sensitizing hypoxic cells in a tumor in a mammal to ionizing radiation administered during radiotherapy, which method comprises administering to a mammal having a tumor containing hypoxic cells a radiation-sensitizing effective amount of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen prior to radiotherapy, wherein said compound is a compound of formula O.dbd.N--S--R, wherein R is selected from the group consisting of a C.sub.1 -C.sub.8 alkyl, a C.sub.3 -C.sub.10 aryl, a C.sub.4 -C.sub.10 heterocyclic nitrogen-containing radical, a C.sub.3 -C.sub.10 aryl substituted with a C.sub.1 -C.sub.3 alkyl, and a C.sub.3 -C.sub.10 cycloalkyl, which R groups may be substituted by 1-3 substituents, which may be the same or different and are selected from the group consisting of halo, hydroxy, C.sub.1 -C.sub.8 alkoxy, amino, amido, formyl, carboxy, and nitro.
- 2. A method of sensitizing hypoxic cells in a tumor in a mammal to ionizing radiation administered during radiotherapy, which method comprises administering to a mammal having a tumor containing hypoxic cells a radiation-sensitizing effective amount of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen prior to radiotherapy, wherein said compound is an S-nitroso adduct of a peptide or a protein.
- 3. The method of claim 2, wherein the S-nitroso adduct is selected form the group consisting of S-nitroso-N-acetyl-penicillamine and S-nitroso-glutathione.
- 4. A method of protecting noncancerous cells or tissues in a mammal during radiotherapy, which method comprises administering to a mammal in need of radiotherapy a radioprotecting effective amount of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen prior to radiotherapy, wherein said compound is a compound of formula O.dbd.N--S--R, wherein R is selected from the group consisting of a C.sub.1 -C.sub.8 alkyl, a C.sub.3 -C.sub.10 aryl, a C.sub.4 -C.sub.10 heterocyclic nitrogen-containing radical, a C.sub.3 -C.sub.10 aryl substituted with a C.sub.1 -C.sub.3 alkyl, and a C.sub.3 -C.sub.10 cycloalkyl, which R groups may be substituted by 1-3 substituents, which may be the same or different and are selected from the group consisting of halo, hydroxy, C.sub.1 -C.sub.8 alkoxy, amino, amido, formyl, carboxy, and nitro.
- 5. A method of protecting noncancerous cells or tissues in a mammal during radiotherapy, which method comprises administering to a mammal in need of radiotherapy a radioprotecting effective amount of a nitric oxide-containing compound that spontaneously releases nitric oxide under physiological conditions without requiring the presence of oxygen prior to radiotherapy, wherein the nitric oxide-containing compound is an S-nitroso adduct of a peptide or a protein.
- 6. The method of claim 5, wherein the S-nitroso adduct is selected from the group consisting of S-nitroso-N-acetylpenicillamine and S-nitro-glutathione.
Parent Case Info
This is a divisional of applications Ser. No. 08/319,888, filed on Oct. 7, 1994 now U.S. Pat. No. 5,650,442 which application is a continuation-in-part of application Ser. No. 08/133,574, filed Oct. 8, 1993 abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5650442 |
Mitchell et al. |
Jul 1997 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
319888 |
Oct 1994 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
133574 |
Oct 1993 |
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