Claims
- 1. A method for the prevention or treatment of diseases and disorders linked to the dysfunctioning of peripheral-type benzodiazepine receptors which comprises administering to a patient in need thereof a compound of formula (I) whereinX is halogen, Y is hydrogen or one or more substituents selected from hydrogen, halogen, hydroxyl, methyl, methoxy and nitro, R1 is (C1-C4)alkyl, R2 and R3 are independently hydrogen or (C1-C4)alkyl, or R2 and R3 together with the nitrogen atom to which they are attached represent a pyrrolidinyl, piperidinyl or morpholinyl group.
- 2. A method according to claim 1 wherein in the compound of formula (I) X is chloro and R1 is methyl.
- 3. A method according to claim 1 wherein the disease or disorder is a degenerative disease of the central or peripheral nervous system.
- 4. A method according to claim 1 wherein the disease or disorder is a cardiac disease or disorder.
- 5. A method according to claim 1 wherein the disease or disorder is a nephropathy.
- 6. A method according to claim 1 wherein the disease or disorder is a cutaneous stress.
- 7. A method according to claim 1 wherein the disease or disorder is a tumour or a cancer.
- 8. A method according to claim 2 wherein the compound of formula (I) is 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide.
- 9. A method according to claim 8 wherein the disease or disorder is a degenerative disease of the central or peripheral nervous system.
- 10. A method according to claim 8 wherein the disease or disorder is a cardiac disease or disorder.
- 11. A method according to claim 8 wherein the disease or disorder is a nephropathy.
- 12. A method according to claim 8 wherein the disease or disorder is a cutaneous stress.
- 13. A method according to claim 8 wherein the disease or disorder is a tumour or a cancer.
Priority Claims (1)
Number |
Date |
Country |
Kind |
99 00806 |
Jan 1999 |
FR |
|
Parent Case Info
This is a 371 of PCT/FR00/00135 filed Jan. 21, 2000.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/FR00/00135 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO00/44384 |
8/3/2000 |
WO |
A |
Foreign Referenced Citations (4)
Number |
Date |
Country |
31 21 137 |
Dec 1982 |
DE |
2 290 292 |
Dec 1995 |
GB |
9815552 |
Apr 1998 |
WO |
9906406 |
Feb 1999 |
WO |
Non-Patent Literature Citations (3)
Entry |
Derwent Abstract (1999)-153682. |
Derwent Abstract (1998)-240772. |
Derwent Abstract (1982)-09422J. |