Claims
- 1. A method for treating amyotrophic lateral sclerosis (ALS) in a subject in need of such treatment comprising administering to the subject R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof in an amount effective to treat ALS in the subject.
- 2. The method of claim 1, wherein the pharmaceutically acceptable salt is the chloride, mesylate, maleate, fumarate, tartarate, hydrochloride, hydrobromide, esylate, p-toluenesulfonate, benzoate, acetate, phosphate or sulfate salt.
- 3. The method of claim 2, wherein the pharmaceutically acceptable salt is the mesylate salt.
- 4. The method of claim 1, wherein the effective amount of R(+)-N-propargyl-1-aminoindan is from about 0.1 to about 20 mg.
- 5. The method of claim 1, further comprising administering 2-amino-6-trifluoromethoxy benzothiazole in an amount effective to treat ALS in the subject.
- 6. A method for treating amyotrophic lateral sclerosis (ALS) in a subject in need of such treatment comprising administering to the subject an amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof and an amount of 2-amino-6-trifluoromethoxy benzothiazole, wherein the amounts when administered together are effective to treat ALS in the subject.
- 7. The method of claim 6, wherein the pharmaceutically acceptable salt is the chloride, mesylate, maleate, fumarate, tartarate, hydrochloride, hydrobromide, esylate, p-toluenesulfonate, benzoate, acetate, phosphate or sulfate salt.
- 8. The method of claim 7, wherein the pharmaceutically acceptable salt is the mesylate salt.
- 9. The method of claim 6, wherein the amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof is effective to treat ALS when administered alone, and the amount of 2-amino-6-trifluoromethoxy benzothiazole is effective to treat ALS when administered alone.
- 10. The method of claim 6, wherein the administration of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof and 2-amino-6-trifluoromethoxy benzothiazole is sustantially concurrent.
- 11. The method of claim 6, wherein R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof is administered and then 2-amino-6-trifluoromethoxy benzothiazole is administered.
- 12. The method of claim 6, wherein the effective amount of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof is from about 0.1 to about 20 mg and the effective amount of 2-amino-6-trifluoromethoxy benzothiazole is from about 5 to about 500 mg.
- 13. A pharmaceutical composition comprising R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof, 2-amino-6-trifluoromethoxy benzothiazole and a pharmaceutically acceptable carrier.
- 14. The pharmaceutical composition of claim 13, formulated for oral, topical, parenteral or nasal administration.
- 15. A package comprising the pharmaceutical composition of claim 13 and instructions for use of the pharmaceutical composition in the treatment of amyotrophic lateral sclerosis (ALS).
- 16. A package comprising a pharmaceutically acceptable preparation of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof, a separate pharmaceutically acceptable preparation of 2-amino-6-trifluoromethoxy benzothiazole, and instructions for use of the preparations in the treatment of amyotrophic lateral sclerosis (ALS).
- 17. Use of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof for manufacturing a medicament useful for treating amyotrophic lateral sclerosis (ALS) in a subject.
- 18. The use of claim 17, wherein the pharmaceutically acceptable salt is the chloride, mesylate, maleate, fumarate, tartarate, hydrochloride, hydrobromide, esylate, p-toluenesulfonate, benzoate, acetate, phosphate or sulfate salt.
- 19. The use of claim 18, wherein the pharmaceutically acceptable salt is the mesylate salt.
- 20. The use of claim 17! wherein the medicment further comprises 2-amino-6-trifluoromethoxy benzothiazole.
- 21. Use of R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof for manufacturing a first medicament in a package having instructions for administration of the first medicament to treat amyotrophic lateral sclerosis (ALS) in a subject.
- 22. The use of claim 21, wherein the pharmaceutically acceptable salt is the chloride, mesylate, maleate, fumarate, tartarate, hydrochloride, hydrobromide, esylate, p-toluenesulfonate, benzoate, acetate, phosphate or sulfate salt.
- 23. The use of claim 22, wherein the pharmaceutically acceptable salt is the mesylate salt.
- 24. The use of claim 21, wherein the package separately comprises a second medicament which comprises 2-amino-6-trifluoromethoxy benzothiazole and instructions for administration of the second medicament to treat ALS in the subject.
- 25. R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof for use in treating amyotrophic lateral sclerosis (ALS).
- 26. The pharmaceutically acceptable salt of claim 25, wherein the pharmaceutically acceptable salt is the chloride, mesylate, maleate, fumarate, tartarate, hydrochloride, hydrobromide, esylate, p-toluenesulfonate, benzoate, acetate, phosphate or sulfate salt for use in treating amyotrophic lateral sclerosis (ALS).
- 27. The pharmaceutically acceptable salt of claim 26, wherein the pharmaceutically acceptable salt is the mesylate salt, for use in treating amyotrophic lateral sclerosis (ALS).
- 28. R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof for use in treating amyotrophic lateral sclerosis (ALS) in combination with 2-amino-6-trifluoromethoxy benzothiazole.
- 29. The pharmaceutically acceptable salt of claim 28, wherein the pharmaceutically acceptable salt is the chloride, mesylate, maleate, fumarate, tartarate, hydrochloride, hydrobromide, esylate, p-toluenesulfonate, benzoate, acetate, phosphate or sulfate salt for use in treating amyotrophic lateral sclerosis (ALS) in combination with 2-amino-6-trifluoromethoxy benzothiazole.
- 30. The pharmaceutically acceptable salt of claim 29, wherein the pharmaceutically acceptable salt is the mesylate salt, for use in treating amyotrophic lateral sclerosis (ALS) in combination with 2-amino-6-trifluoromethoxy benzothiazole.
Parent Case Info
[0001] This application claims the benefit of U.S. Provisional Application No. 60/426,543, filed Nov. 15, 2002, the entire contents of which are hereby incorporated by reference.
[0002] Throughout this application various publications are referenced in parenthesis. Full citations for these publications may be found listed in alphabetical order at the end of the specification immediately preceding the claims. The disclosures of these publications in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this invention pertains.
Provisional Applications (1)
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Number |
Date |
Country |
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60426543 |
Nov 2002 |
US |