Claims
- 1. A method of treating sexual dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof with the proviso that said dopamine D4 receptor agonist is not 5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10, 11-diol.
- 2. A method of treating male sexual dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof with the proviso that said dopamine D4 receptor agonist is not 5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol.
- 3. A method of treating female sexual dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof with the proviso that said dopamine D4 receptor agonist is not 5,6,6,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol.
- 4. A method of treating male erectile dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof with the proviso that said dopamine D4 receptor agonist is not 5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11 -diol.
- 5. A method of treating sexual dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof.
- 6. A method of treating male sexual dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof
- 7. A method of treating female sexual dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof
- 8. A method of treating male erectile dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof
- 9. The method of claim 6 wherein said selective dopamine D4 receptor agonist is N-{[4-(2-cyanophenyl)l1-piperazinyl]methyl}-3-methylb enzamide or a pharmaceutically acceptable salt thereof
- 10. The method of claim 7 wherein said selective dopamine D4 receptor agonist is N-{[4-(2-cyanophenyl)-1-piperazinyl]methyl}-3-methylbenzamide or a pharmaceutically acceptable salt thereof
- 11. The method of claim 8 wherein said selective dopamine D4 receptor agonist is N-{[4-(2-cyanophenyl)-1-piperazinyl]methyl}-3-methylbenzamide or a pharmaceutically acceptable salt thereof
- 12. The method of claim 6 wherein said selective dopamine D4 receptor agonist is 5-fluoro-2- {[4-(2-pyridinyl)-1-piperazinyl]methyl}-1H-indole or a pharmaceutically acceptable salt thereof
- 13. The method of claim 7 wherein said selective dopamine D4 receptor agonist is 5-fluoro-2-{[4-(2-pyridinyl)-1-piperazinyl]methyl}-1H-indole or a pharmaceutically acceptable salt thereof
- 14. The method of claim 8 wherein said selective dopamine D4 receptor agonist is 5-fluoro-2-{[4-(2-pyridinyl)- 1-piperazinyl]methyl}-1H-indole or a pharmaceutically acceptable salt thereof
- 15. A method of claim 5 wherein said selective dopamine D4 receptor agonist is 3 fold more selective for the D4 receptor than for the D2 receptor.
- 16. A method of claim 5 wherein said selective dopamine D4 receptor agonist is 25 fold more selective for the D4 receptor than for the D2 receptor.
- 17. A method of claim 5 wherein said selective dopamine D4 receptor agonist is 50 fold more selective for the D4 receptor than for the D2 receptor.
- 18. A method of claim 5 wherein said selective dopamine D4 receptor agonist is 100 fold more selective for the D4 receptor than for the D2 receptor.
- 19. A method of claim 5 wherein said selective dopamine D4 receptor agonist is 200 fold more selective for the D4 receptor than for the D2 receptor.
- 20. A method of claim 5 wherein said selective dopamine D4 receptor agonist is 300 fold more selective for the D4 receptor than for the D2 receptor.
- 21. A method of claim 5 wherein said selective dopamine D4 receptor agonist is 500 fold more selective for the D4 receptor than for the D2 receptor.
- 22. A method of claim 5 wherein said selective dopamine D4 receptor agonist is 1000 fold more selective for the D4 receptor than for the D2 receptor.
- 22. A method of treating sexual dysfunction in a mammal comp rising administering to a mammal in need of such treatment a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof wherein said agonist does not cause significant emesis.
- 23. A method of treating male sexual dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof wherein said agonist does not cause significant emesis.
- 24. A method of treating female sexual dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof wherein said agonist does not cause significant emesis.
- 25. A method of treating male erectile dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof wherein said agonist does not cause significant emesis.
- 26. A method of treating sexual dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier.
- 27. A method of treating male sexual dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier.
- 28. A method of treating female sexual dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier.
- 29. A method of treating male erectile dysfunction in a mammal comprising administering to a mammal in need of such treatment a therapeutically effective amount of a selective dopamine D4 receptor agonist or a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier.
- 30. A method of treating male erectile dysfunction comprising administering to a mammal in need of such treatment a therapeutically effective amount of one or more selective dopamine D4 receptor agonists in combination with a phosphodiesterase 5 inhibitor or an adrenoceptor antagonist
TECHNICAL FIELD
[0001] This application claims priority to U.S. Provisional Patent Application Serial No. 60/252,768, filed Nov. 22, 2000.
[0002] The present invention relates to the use of selective dopamine D4 receptor agonists and to compositions containing selective dopamine D4 receptor agonists for the treatment of sexual dysfunction.
Provisional Applications (1)
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Number |
Date |
Country |
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60252768 |
Nov 2000 |
US |