Claims
- 1. A method of negating the toxic effects of platinum compounds, which comprises administering to a patient having a problem due to undergoing platinum therapy an effective amount of at least one selenium-containing compound selected from the group consisting of sodium selenite, sodium selenate, selenium yeast, an amino acid containing selenium, an amine containing selenium, a seleno carbohydrate and a seleno heterocyclic base,
- said amino acid containing selenium being at least one member selected from the group consisting of selenomethionine, selenocysteine, Se-methylselenocysteine, selenohomomethionine, selenohomocystine and selenocystine,
- said amine containing selenium being at least one member selected from the group consisting of .beta.-seleno ethylamine, 2-phenylseleno-1,3-diaminopropane, 4-phenylselenomethylene-1,2-diaminobenzene, 2-seleno-1,3-diaminopropane and 4-phenylselenosemicarbazide,
- said seleno carbohydrate being at least one member selected from the group consisting of 1-.beta.-D-seleno-2,3,4,6-tetra-O-acetyl-D-glucopyranose, selenoglucopyranose, 1-.beta.-D-seleno-2,3,4,6-tetra-O-acetyl-D-galactopyranose, 1-.beta.-D-selenogalactopyranose, 1-.alpha.-D-seleno-2,3,4,6-tetra-O-acetyl-D-mannopyranose and 1-.alpha.-D-selenomannopyranose,
- said seleno heterocyclic base being at least one member selected from the group consisting of 6-selenoguanine, 6-selenoguanosine, 5-selenocytosine, 5-selenocytidine, 6-selenopurine, 6-selenopurineriboside, 8-selenoguanine, 8-selenoguanosine, 8-selenoadenine and 8-selenoadenosine.
- 2. A method according to claim 1, wherein said effective amount of a selenium-containing compound is about 0.6 to 300 mg for adults per day.
Parent Case Info
This is a division of Ser. No. 484,874 (4/14/83), now U.S. Pat. No. 4,556,571, which is a C-I-P of Ser. No. 312,300 (1/016/84), now abandoned.
US Referenced Citations (13)
Non-Patent Literature Citations (1)
Entry |
Merck Index, 1976 (9th Ed), pp. 1091-1092. |
Divisions (1)
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Number |
Date |
Country |
Parent |
484874 |
Apr 1983 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
312300 |
Jan 1984 |
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