Claims
- 1. A method of treating a viral disease due to a virus selected from the group consisting of Herpesviridae, Poxviridae, Picornaviridae, Orthomyxoviridae and Paramyxoviridae in a warm-blooded animal in need thereof comprising administering to said animal after infection an in-vivo anti-virally effective amount of a pharmaceutically acceptable salt of a compound which is N-acetyl-muramyl-L-alanyl-D-isoglutaminyl-L-alanine-2-(1,2-dipalmitoyl-sn-glycero-3-hydroxyphosphoryloxy)-ethylamide in the absence of a vaccine.
- 2. The method of claim 1, wherein the sodium salt of said compound is administered as the sole active ingredient.
- 3. The method of claim 1, wherein said salt is administered in the form of a pharmaceutical composition containing a pharmaceutical carrier and less than 1% by weight of said salt.
- 4. The method of claim 1, wherein a single dose of not more than 10 mg of said salt is administered once to a warm-blooded animal of approximately 70 kg body weight.
- 5. The method of claim 4, wherein said dose is administered about 7 days after infection.
- 6. The method of claim 1 wherein a pharmaceutically acceptable salt of N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine-2-(1,2-dipalmitoyl-sn-glycero-3-hydroxyphosphoryloxy)-ethylamide is administered intranasally.
- 7. The method of claim 1 wherein a pharmaceutically acceptable salt of N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine-2-(1,2-dipalmitoyl-sn-glycero-3-hydroxyphosphoryloxy)-ethylamide is administered orally.
- 8. The method of claim 1 wherein said viral disease is due to a virus selected from the group consisting of Herpes simplex viruses belonging to Herpesviridae or Influenza A and Influenza B viruses belonging to Orthomyxoviridae.
- 9. The method of claim 1 wherein said viral disease is caused by a vaccinal virus belonging to Poxviridae, parainfluenza virus belonging to Paramyxoviridae or encephalomyocarditis virus belonging to Picornaviridae.
Priority Claims (1)
Number |
Date |
Country |
Kind |
4528/82 |
Jul 1982 |
CHX |
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Parent Case Info
This application is a continuation of application Ser. No. 07/319,909 filed Mar. 3, 1989, now abandoned; which is a continuation of application Ser. No. 06/750,667 filed Jul. 1, 1985, now abandoned; which is a continuation of Ser. No. 06/640,547 filed Aug. 14, 1984, now abandoned; which is a continuation of Ser. No. 06/515,006 filed Jul. 18, 1983, now abandoned.
US Referenced Citations (19)
Foreign Referenced Citations (4)
Number |
Date |
Country |
0056992 |
Feb 1982 |
EPX |
72111 |
Feb 1983 |
EPX |
72286 |
Feb 1983 |
EPX |
2051069 |
Jan 1981 |
GBX |
Non-Patent Literature Citations (10)
Entry |
The Merck manual of Diagnosis and Therapy, 5th ed., Pub. by Merck Sharp and Dohme Research Lab. (1987) pp. 158-186. |
Stedman's Medical Dictionary, 23rd ed. 1976, p. 1554. |
Lukas et al., Archives of Virology vol. 49 pp. 1-11 (1975). |
Avery's Drug Treatment 3rd Ed. pp. 1230-1249 (1987). |
Derwent Abstract of European 138558 (Apr. 1985). |
Derwent Abstract of Japanese 52087221 (1977). |
Journal of Immunological Methods vol. 65 pp. 295-306 (1983). |
Chem. Abstr. 66:95388g (1967). |
Chem. Abstr. 69:95890b (1968). |
Chem. Abstr. 71:123473e (1969). |
Continuations (4)
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Number |
Date |
Country |
Parent |
319909 |
Mar 1989 |
|
Parent |
750667 |
Jul 1985 |
|
Parent |
640547 |
Aug 1984 |
|
Parent |
515006 |
Jul 1983 |
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