The overarching goal of this application is to build an Artificial Intelligence (AI) and Technology Collaboratory (AITC) ecosystem that will serve as a national resource to promote the development and implementation of novel AI and technology approaches to improve care and health outcomes for older Americans. The specific aims are: 1) To engage AI and geriatric/gerontology investigators from across the country and to identify, validate, test, and develop new AI and technologies relevant to improving the health and wellbeing of older adults through crucial pilot study mechanisms; 2) To serve as a national resource center that stimulates and leads the development and implementation of effective novel AI and technology approaches and products that will promote the health, wellbeing and independence of all older Americans; 3) To support the engagement of stakeholders in AI research; 4) To build an ecosystem of overlapping innovation and business, academic, and communities- of-practice networks ; and 5) To provide highest quality expertise, support, and infrastructure needed to disseminate technical and policy guidelines and best practices for effectively incorporating AI approaches and technology for older Americans, in partnership with private industry, angel investors, venture capital firms, and healthcare systems. This AITC is directed by a multi-PI interdisciplinary team led by two world-class experienced investigators who have long worked successfully in the fields of AI and technology development areas partnered with investigators who have long and successfully worked at the translational interface that connects real-world medical, cognitive, and functional declines that impact older adults with medical and technological solutions. Each of these investigators has a complementary skill set and a long track records of organizing transdisciplinary teams and consortiums of investigators around core themes. This interdisciplinary, accomplished, and highly visible leadership team will work together to develop vision for the next generation of AI in aging science and to build a scientifically and culturally diverse community of AI scholars and trainees around Aging. To achieve our goals, we designed the JHU AITC to have robust scientific and technological expertise that are described in eight core components. This infrastructure will support the implementation of stakeholder input and the identification of relevant technologies and investigators locally and nationally through a vetting and feasibility testing process of both technology and data processes. It will include a pilot testing phase and related oversight process. We have also established a key partnership with the Iowa office of Rural Health and Veterans Rural Health Resource Centers Leadership and with organizations within Johns Hopkins University that focus on improvements in the health and well-being of older adults in underserved urban communities. Connections with key academic, industry partners have also been established to accelerate the development of relevant technologies into products. This team is dedicated to developing the next AI scientific advances and disseminating resulting strategies into practice and policy that will maximize health, well-being, and independence for older adults.