Patent Grant
10828195
This disclosure relates to reducing intraocular pressure within the eye. This disclosure also relates to a treatment of glaucoma and/or other ocular disorders wherein aqueous humor is permitted to flow out of an anterior chamber of the eye through a surgically implanted pathway.
A human eye is a specialized sensory organ capable of light reception and is able to receive visual images. Aqueous humor is a transparent liquid that fills at least the region between the cornea, at the front of the eye, and the lens. A trabecular meshwork, located in an anterior chamber angle, which is formed between the iris and the cornea, normally serves as a drainage channel for aqueous humor from the anterior chamber so as to maintain a balanced pressure within the anterior chamber of the eye.
About two percent of people in the United States have glaucoma. Glaucoma is a group of eye diseases encompassing a broad spectrum of clinical presentations, etiologies, and treatment modalities. Glaucoma causes pathological changes in the optic nerve, visible on the optic disk, and it causes corresponding visual field loss, resulting in blindness if untreated. Lowering intraocular pressure is the major treatment goal in all glaucomas.
In glaucomas associated with an elevation in eye pressure (intraocular hypertension), the source of resistance to outflow is mainly in the trabecular meshwork. The tissue of the trabecular meshwork normally allows the aqueous humor (hereinafter referred to as “aqueous”) to enter Schlemm's canal, which then empties into aqueous collector channels in the posterior wall of Schlemm's canal and then into aqueous veins, which form the episcleral venous system. Aqueous is continuously secreted by a ciliary body around the lens, so there is a constant flow of aqueous from the ciliary body to the anterior chamber of the eye. Pressure within the eye is determined by a balance between the production of aqueous and its exit through the trabecular meshwork (major route) and uveoscleral outflow (minor route). The portion of the trabecular meshwork adjacent to Schlemm's canal (the juxtacanalicular meshwork) causes most of the resistance to aqueous outflow.
While a majority of the aqueous leaves the eye through the trabecular meshwork and Schlemm's canal, it is believed that about 10 to about 20 percent of the aqueous in humans leaves through the uveoscleral pathway. The degree with which uveoscleral outflow contributes to the total outflow of the eye appears to be species dependent. As used herein, the term “uveoscleral outflow pathway” is to be given its ordinary and customary meaning to a person of ordinary skill in the art (and it is not to be limited to a special or customized meaning), and refers without limitation to the space or passageway whereby aqueous exits the eye by passing through the ciliary muscle bundles located angle of the anterior chamber and into the tissue planes between the choroid and the sclera, which extend posteriorly to the optic nerve. From these tissue planes, it is believed that the aqueous travels through the surrounding scleral tissue and drains via the scleral and conjunctival vessels, or is absorbed by the uveal blood vessels. It is unclear from studies whether the degree of physiologic uveoscleral outflow is pressure-dependent or pressure-independent. As used herein, the term “supraciliary space” is to be given its ordinary and customary meaning to a person of ordinary skill in the art (and it is not to be limited to a special or customized meaning), and refers without limitation to the portion of the uveoscleral pathway through the ciliary muscle and between the ciliary body and the sclera, and the term “suprachoroidal space” is to be given its ordinary and customary meaning to a person of ordinary skill in the art (and it is not to be limited to a special or customized meaning), and refers without limitation to the portion of the uveoscleral pathway between the choroid and sclera. Although it is not completely understood, some studies have suggested that there may be a “compact zone” of connective tissue associated with the junction between the retina and ciliary body, known as the ora serrata. This “compact zone” may act as a site of resistance along the uveoscleral outflow pathway. The ora serrata can vary in length from about 5.75 mm to 7.5 mm nasally to about 6.5 mm to about 8.5 mm temporally. Other studies suggest that the ciliary muscle bundles are the primary site of resistance.
Certain therapeutic agents have been shown to reduce intraocular pressure by increasing uveoscleral outflow, but the mechanism by which uveoscleral outflow is increased is unclear. Some studies have suggested that relaxation of the ciliary muscle may reduce resistance through the ciliary muscle bundles to increase flow. Other studies suggest that dilation of the post-capillary venules or constriction of the pre-capillary arterioles may reduce downstream fluid pressure and increase uveoscleral outflow.
Glaucoma is broadly classified into two categories: closed-angle glaucoma, also known as angle closure glaucoma, and open-angle glaucoma. Closed-angle glaucoma is caused by closure of the anterior chamber angle by contact between the iris and the inner surface of the trabecular meshwork. Closure of this anatomical angle prevents normal drainage of aqueous from the anterior chamber of the eye. Open-angle glaucoma is any glaucoma in which the exit of aqueous through the trabecular meshwork is diminished while the angle of the anterior chamber remains open. For most cases of open-angle glaucoma, the exact cause of diminished filtration is unknown. Primary open-angle glaucoma is the most common of the glaucomas, and is often asymptomatic in the early to moderately advanced stages of glaucoma. Patients may suffer substantial, irreversible vision loss prior to diagnosis and treatment. However, there are secondary open-angle glaucomas that may include edema or swelling of the trabecular spaces (e.g., from corticosteroid use), abnormal pigment dispersion, or diseases such as hyperthyroidism that produce vascular congestion.
All current therapies for glaucoma are directed toward decreasing intraocular pressure. Currently recognized categories of drug therapy for glaucoma include but are not limited to: (1) Miotics (e.g., pilocarpine, carbachol, and acetylcholinesterase inhibitors), (2) Sympathomimetics (e.g., epinephrine and dipivalylepinephxine), (3) Beta-blockers (e.g., betaxolol, levobunolol and timolol), (4) Carbonic anhydrase inhibitors (e.g., acetazolamide, methazolamide and ethoxzolamide), and (5) Prostaglandins (e.g., metabolite derivatives of arachindonic acid). Medical therapy includes topical ophthalmic drops or oral medications that reduce the production of aqueous or increase the outflow of aqueous. However, drug therapies for glaucoma are sometimes associated with significant side effects. The most frequent and perhaps most serious drawback to drug therapy, especially the elderly, is patient compliance. Patients often forget to take their medication at the appropriate times or else administer eye drops improperly, resulting in under- or overdosing. Patient compliance is particularly problematic with therapeutic agents requiring dosing frequencies of three times a day or more, such as pilocarpine. Because the effects of glaucoma are irreversible, when patients dose improperly, allowing ocular concentrations to drop below appropriate therapeutic levels, further permanent damage to vision occurs. Furthermore, current drug therapies are targeted to be deposited directly into the ciliary body where the aqueous is produced. And current therapies do not provide for a continuous slow-release of the drug. When drug therapy fails, surgical therapy is pursued.
Surgical therapy for open-angle glaucoma consists of laser trabeculoplasty, trabeculectomy, and implantation of aqueous shunts after failure of trabeculectomy or if trabeculectomy is unlikely to succeed. Trabeculectomy is a major surgery that is widely used and is augmented with topically applied anticancer drugs, such as 5-flurouracil or mitomycin-C to decrease scarring and increase the likelihood of surgical success.
Approximately 100,000 trabeculectomies are performed on Medicare-age patients per year in the United States. This number would likely increase if ocular morbidity associated with trabeculectomy could be decreased. The current morbidity associated with trabeculectomy consists of failure (10-15%); infection (a life long risk of 2-5%); choroidal hemorrhage, a severe internal hemorrhage from low intraocular pressure, resulting in visual loss (1%); cataract formation; and hypotony maculopathy (potentially reversible visual loss from low intraocular pressure). For these reasons, surgeons have tried for decades to develop a workable surgery for reducing intraocular pressure.
The surgical techniques that have been tried and practiced are goniotomy/trabeculotomy and other mechanical disruptions of the trabecular meshwork, such as trabeculopuncture, goniophotoablation, laser trabecular ablation, and goniocurretage. These are all major operations and are briefly described below.
Goniotomy and trabeculotomy are simple and directed techniques of microsurgical dissection with mechanical disruption of the trabecular meshwork. These initially had early favorable responses in the treatment of open-angle glaucoma. However, long-term review of surgical results showed only limited success in adults. In retrospect, these procedures probably failed due to cellular repair and fibrosis mechanisms and a process of “filling in.” Filling in is a detrimental effect of collapsing and closing in of the created opening in the trabecular meshwork. Once the created openings close, the pressure builds back up and the surgery fails.
Q-switched Neodymium (Nd) YAG lasers also have been investigated as an optically invasive trabeculopuncture technique for creating full-thickness holes in trabecular meshwork. However, the relatively small hole created by this trabeculopuncture technique exhibits a filling-in effect and fails.
Goniophotoablation is disclosed by Berlin in U.S. Pat. No. 4,846,172 and involves the use of an excimer laser to treat glaucoma by ablating the trabecular meshwork. This method did not succeed in a clinical trial. Hill et al. used an Erbium YAG laser to create full-thickness holes through trabecular meshwork (Hill et al., Lasers in Surgery and Medicine 11:341346, 1991). This laser trabecular ablation technique was investigated in a primate model and a limited human clinical trial at the University of California, Irvine. Although ocular morbidity was zero in both trials, success rates did not warrant further human trials. Failure was again from filling in of surgically created defects in the trabecular meshwork by repair mechanisms. Neither of these is a viable surgical technique for the treatment of glaucoma.
Goniocurretage is an “ab interno” (from the inside), mechanically disruptive technique that uses an instrument similar to a cyclodialysis spatula with a microcurette at the tip. Initial results were similar to trabeculotomy: it failed due to repair mechanisms and a process of filling in.
Although trabeculectomy is the most commonly performed filtering surgery, viscocanalostomy (VC) and nonpenetrating trabeculectomy (NPT) are two new variations of filtering surgery. These are “ab externo” (from the outside), major ocular procedures in which Schlemm's canal is surgically exposed by making a large and very deep scleral flap. In the VC procedure, Schlemm's canal is cannulated and viscoelastic substance injected (which dilates Schlemm's canal and the aqueous collector channels). In the NPT procedure, the inner wall of Schlemm's canal is stripped off after surgically exposing the canal.
Trabeculectomy, VC, and NPT involve the formation of an opening or hole under the conjunctiva and scleral flap into the anterior chamber, such that aqueous is drained onto the surface of the eye or into the tissues located within the lateral wall of the eye. These surgical operations are major procedures with significant ocular morbidity. When trabeculectomy, VC, and NPT are thought to have a low chance for success, a number of implantable drainage devices have been used to ensure that the desired filtration and outflow of aqueous through the surgical opening will continue. The risk of placing a glaucoma drainage device also includes hemorrhage, infection, and diplopia (double vision).
All of the above embodiments and variations thereof have numerous disadvantages and moderate success rates. They involve substantial trauma to the eye and require great surgical skill in creating a hole through the full thickness of the sclera into the subconjunctival space. The procedures are generally performed in an operating room and involve a prolonged recovery time for vision. The complications of existing filtration surgery have prompted ophthalmic surgeons to find other approaches to lowering intraocular pressure.
Because the trabecular meshwork and juxtacanalicular tissue together provide the majority of resistance to the outflow of aqueous, they are logical targets for surgical removal in the treatment of open-angle glaucoma. In addition, minimal amounts of tissue need be altered and existing physiologic outflow pathways can be utilized. Some procedures bypass the trabecular meshwork and juxtacanalicular tissue to drain fluid to physiologic outflow channels. However, in severe cases, it has been found that these procedures do not sufficiently reduce intraocular pressure.
As reported in Arch. Ophthalm. (2000) 118:412, glaucoma remains a leading cause of blindness, and filtration surgery remains an effective, important option in controlling glaucoma. However, modifying existing filtering surgery techniques in any profound way to increase their effectiveness appears to have reached a dead end.
A need exists for an extended, site-specific treatment method for placing a drainage implant (preferably by an ab interno implantation procedure) for diverting aqueous humor in an eye from the anterior chamber to a location within the eye that will permit further reduction of intraocular pressure. One such location disclosed herein is the uveoscleral outflow pathway, which comprises the supraciliary space and/or the suprachoroidal space. In some embodiments of the present disclosure, a method is provided for implanting a drainage implant ab interno in an eye to divert aqueous humor from the anterior chamber to the supraciliary space.
In accordance with some embodiments of the present invention, a method for reducing intraocular pressure in an eye of a mammal (e.g., human) is provided, comprising introducing an ocular implant into the anterior chamber of the eye, the ocular implant having proximal and distal ends, cutting eye tissue using a distal portion of the implant at a location posterior of a scleral spur of the eye, advancing the implant from the anterior chamber into the cut eye tissue such that the distal end is located in the suprachoroidal space and the proximal end is located in the anterior chamber, and conducting aqueous humor between the proximal and distal ends of the implant.
An ocular implant is disclosed in accordance with some embodiments of the present invention. In some embodiments, the implant comprises a substantially straight, rigid, generally cylindrical body of a length no greater than 7 mm, preferably not greater than about 5 mm, and more preferably not greater than about 4 mm and not shorter than about 2 mm. The body has a tip that narrows toward an end, at least one inlet communicating with at least one inner lumen that terminates at one or more outlets. The lumen is of a sufficient length to extend from an anterior chamber to a suprachoroidal space of an eye. Means are provided for regulating fluid flow through the lumen.
A method for regulating intraocular pressure is disclosed in accordance with some embodiments of the present invention. In some embodiments, the method comprises placing an elongated implant in eye tissue with an inlet in an anterior chamber and an outlet in a uveoscleral outflow pathway of an eye, and utilizing intraocular pressure to apply a force to move a valve surface within the implant in a direction transverse to a longitudinal axis of the implant such that aqueous humor flows from the anterior chamber to the uveoscleral outflow pathway at intraocular pressures greater than a threshold pressure.
An intraocular implant is disclosed in accordance with some embodiments of the present invention. In some embodiments, the intraocular implant comprises an inlet portion that provides an ingress flow path comprising one or more influent openings that have a total cross-sectional flow area and communicate with an interior chamber within the implant, an outlet portion providing an egress flow path comprising one or more effluent openings, and a pressure regulation valve having a deflectable plate or diaphragm with a surface area exposed to fluid within the interior chamber. The surface area is substantially greater than the total cross-sectional flow area. The valve is disposed between the interior chamber and the one or more effluent openings such that movement of the deflectable plate regulates flow from the interior chamber to the one or more effluent openings. The plate extends in a direction generally parallel to the inlet flow path and to the outlet flow path.
A method of performing surgery to lower intraocular pressure of an eye is disclosed in accordance with some embodiments of the present invention. In some embodiments, the method comprises providing an opening into an anterior chamber of the eye, inserting an instrument into the anterior chamber through said opening to perform a cataract extraction from the eye, providing an ocular implant having an inflow portion in fluid communication with an outflow portion, transporting the ocular implant from the opening through the anterior chamber of the eye to the anterior chamber angle of the eye, positioning the ocular implant such that the inflow portion of the ocular implant is positioned in the anterior chamber and the outflow portion of the ocular implant is positioned in the suprachoroidal space, and permitting aqueous humor to flow from the anterior chamber of the eye through the inflow portion of the ocular implant to the outflow portion of the ocular implant and into the suprachoroidal space of the eye.
A system for treating an ocular disorder in a patient is disclosed in accordance with some embodiments of the present invention. In some embodiments, the system comprises a drainage implant which, following implantation at an implantation site, conducts fluid from the anterior chamber to a uveoscleral outflow pathway, such as the supraciliary space and a delivery instrument for implanting the drainage implant. The instrument has a distal end sufficiently sharp to penetrate eye tissue at an insertion site near the limbus of the patient's eye, and is sufficiently long to advance the implant transocularly from the insertion site across the anterior chamber to the implantation site. The instrument also has a sufficiently small cross section such that the insertion site self seals without suturing upon withdrawal of the instrument from the eye. The instrument comprises a plurality of members longitudinally moveable relative to each other and a seal between the members to prevent aqueous humor from passing between the members proximal the seal when the instrument is in the eye.
A system for treating an ocular disorder in a patient is disclosed in accordance with some embodiments of the present invention. In some embodiments, the system comprises a shunt that includes a central lumen that terminates at an outlet opening at a distal end of the shunt and a delivery instrument for implanting the shunt. The shunt further includes a transitional region that continually decreases in the radial dimension toward the distal end. The shunt also has a sufficient length such that, following implantation at an implantation site, the lumen conducts fluid from the anterior chamber to a uveoscleral outflow pathway of an eye. The delivery instrument comprises an outer needle, an implantation member and a trocar. The outer needle has a distal end sufficiently sharp to penetrate eye tissue at an insertion site near the limbus of the patient's eye. The implantation member is sufficiently long to advance the shunt transocularly from the insertion site across the anterior chamber to the implantation site, and is movable along an axis of the delivery instrument. The trocar cooperates with the implantation member and is movable relative to the implantation member. The trocar is sized to extend through the central lumen of the shunt and has a distal portion that narrows toward a distal end of the trocar. The distal end of the trocar is rounded.
A method for treating glaucoma is disclosed in accordance with some embodiments of the present invention. In some embodiments, the method comprises forming as incision in eye tissue located near the limbus of the eye, introducing a delivery instrument through the incision, the delivery instrument carrying a drainage device, implanting the drainage device in eye tissue at a location posterior of a scleral spur of the eye, without introducing a viscoelectic material into the anterior chamber, to establish a flow path for aqueous humor from the anterior chamber to a physiologic outflow path, and withdrawing the delivery instrument from the eye, wherein the incision is sufficient small that it is self-sealing once the delivery instrument is withdrawn.
A method for lowering intraocular pressure in a patient having at least one ocular shunt implanted in the trabecular meshwork to drain aqueous humor from the anterior chamber towards Schlemm's canal is disclosed in accordance with some embodiments of the present invention. In some embodiments, the method comprises introducing a drainage device through tissue adjacent the limbus into the anterior chamber, advancing the drainage device across the anterior chamber to a location near the scleral spur, and implanting the drainage device in eye tissue at a location spaced from the at least one ocular shunt and the trabecular meshwork to establish a flow path from the anterior chamber towards the suprachoroidal space.
A further aspect of the invention involves a system for treating glaucoma. The system comprises a plurality of implants, each implant has a distal end sufficiently sharp to extend through tissue into a physiologic outflow pathway, and an instrument that has a chamber in which the implants are loaded for serial delivery into eye tissue. At least a first implant of the plurality of implants includes a recess that is sized to receive a distal end of a second implant of the plurality of implants. The recess is shaped so that with the implants contacting each other when placed in tandem in the instrument, the distal end of the second implant does not bear against the first implant.
Further aspects, features and advantages of the present invention will become apparent from the detailed description of the preferred embodiments of ocular implants, methods of implantation, and treatment courses that follow.
These and other features, aspects, and advantages of the present disclosure will now be described with reference to the drawings of embodiments, which embodiments are intended to illustrate and not to limit the disclosure.
An ophthalmic implant system is provided that comprises a shunt and a delivery instrument for implanting the shunt. While this and other systems and associated methods are described herein in connection with glaucoma treatment, the disclosed systems and methods can be used to treat other types of ocular disorders in addition to glaucoma.
The shunt, following implantation at an implantation site, drains fluid from the anterior chamber into a physiologic outflow space. In some embodiments, the shunt is configured to provide a fluid flow path for draining aqueous humor from the anterior chamber of an eye to the uveoscleral outflow pathway to reduce intraocular pressure. In some embodiments, an instrument is provided for delivering and/or implanting the drainage shunt ab interno in an eye to divert aqueous humor from the anterior chamber to the uveoscleral outflow pathway. In some embodiments, a method is provided for implanting a drainage shunt ab interno in an eye to divert aqueous humor from the anterior chamber to the uveoscleral outflow pathway. In some embodiments, the aqueous humor is diverted to the supraciliary space or the suprachoroidal space of the uveoscleral outflow pathway.
The term “shunt” as used herein is a broad term, and is to be given its ordinary and customary meaning to a person of ordinary skill in the art (and it is not to be limited to a special or customized meaning), and refers without limitation to an implant defining one or more fluid passages. The fluid passage(s) in some embodiments remains patent and, in other embodiments, the passage(s) is fully or partially occluded under at least some circumstances (e.g., at lower intraocular pressure levels). The shunts may feature a variety of characteristics, described in more detail below, which facilitate the regulation of intraocular pressure. The mechanical aspects and material composition of the shunt can be important for controlling the amount and direction of fluid flow. Therefore, various examples of shunt dimensions, features, tip configurations, material flexibility, coatings, and valve design, in accordance with some embodiments of the present disclosure, are discussed in detail below.
The delivery instruments, described in more detail below, may be used to facilitate delivery and/or implantation of the shunt to the desired location of the eye. The delivery instrument preferably is used to place the shunt into a desired position by application of a continual implantation force, by tapping the shunt into place using a distal portion of the delivery instrument, or by a combination of these methods. The design of the delivery instruments may take into account, for example, the angle of implantation and the location of the shunt relative to an incision. For example, in some embodiments, the delivery instrument may have a fixed geometry, be shape-set, or actuated. In some embodiments, the delivery instrument may have adjunctive or ancillary functions. In some embodiments, the delivery instrument may additionally be used to, for example, inject dye and/or viscoelastic fluid, to dissect, or be used as a guidewire.
The shunt can be advanced through the ciliary attachment tissue, which lies to the posterior of the scleral spur, during implantation. This tissue typically is fibrous or porous, which is relatively easy to pierce or cut with a surgical device, and lies inward of the scleral spur. The shunt can be advanced through this tissue and abut against the sclera once the shunt extends into the uveoscleral outflow pathway. The shunt can then slide within the uveoscleral outflow pathway along the interior wall of the sclera. As the shunt is advanced into the uveoscleral outflow pathway and against the sclera, the shunt will likely be oriented at an angle with respect to the interior wall of the sclera. The shunt is advanced until it reaches the desired implantation site within the uveoscleral outflow pathway. In some embodiments, the shunt is advanced into the ciliary body or ciliary muscle bundles to achieve drainage into the supraciliary space. In other embodiments, the shunt is advanced through the ciliary body or ciliary muscle bundles to achieve fluid communication between the anterior chamber and the suprachoroidal space. In still other embodiments, the shunt is advanced into the compact zone or through the compact to drain aqueous humor into the more distal portions of the suprachoroidal space.
Shunts
The disclosed embodiments include shunts that provide a fluid flow path for conducting aqueous humor from the anterior chamber of an eye to the uveoscleral outflow pathway to reduce intraocular pressure, preferably below episcleral venous pressure without hypotony. The shunts can have an inflow portion and an outflow portion. The outflow portion of the shunt preferably is disposed at or near a distal end of the shunt. When the shunt is implanted, the inflow portion may be sized and configured to reside in the anterior chamber of the eye and the outflow portion may be sized and configured to reside in the uveoscleral outflow pathway. In some embodiments, the outflow portion may be sized and configured to reside in the supraciliary region of the uveoscleral outflow pathway or in the suprachoroidal space.
One or more lumens can extend through the shunt to form at least a portion of the flow path. Preferably, there is at least one lumen that operates to conduct the fluid through the shunt. Each lumen preferably extends from an inflow end to an outflow end along a lumen axis. In some embodiments the lumen extends substantially through the longitudinal center of the shunt. In other embodiments, the lumen can be offset from the longitudinal center of the shunt. In still other embodiments, the flow path can be defined by grooves, channel or reliefs formed on an outer surface of the shunt body.
One or more openings can extend through the wall of the shunt. In some embodiments, the openings can extend through a middle portion of the shunt. In other embodiments the openings can extend through other portions of the shunt. The openings can be one or more of a variety of functions. One such function is that when the shunt is inserted into the suprachoroidal or supraciliary space, the openings provide a plurality of routes through which the aqueous humor can drain. For example, once the shunt is inserted into the eye, if the shunt only has one outflow channel (e.g., one end of a lumen), that outflow channel can be plugged, for example, by the shunt's abutment against the interior surface of the sclera or the outer surface of the choroid. Additionally, the outflow channel can be clogged with tissue that is accumulated or cored during the advancement of the shunt through the fibrous or porous tissue. A plurality of openings provides a plurality of routes through which the fluid may flow to maintain patency and operability of the drainage shunt. In embodiments where the shunt has a porous body, the openings can define surface discontinuities to assist in anchoring the shunt once implanted.
The shunt in some embodiments can include a distal portion that is sufficiently sharp to pierce eye tissue near the scleral spur of the eye, and that is disposed closer to the outlet portion than to the inlet portion. In some embodiments, the distal portion is located at the distal end of the implant. The distal portion can be sufficiently blunt so as not to substantially penetrate scleral tissue of the eye. In some embodiments, the shunts have a generally sharpened forward end and are self-trephinating, i.e., self-penetrating, so as to pass through tissue without pre-forming an incision, hole or aperture. The sharpened forward end can be, for example, conical or tapered. The tip can be sufficiently sharp to pierce eye tissue near the scleral spur of the eye. The tip also can be sufficiently blunt so as not to substantially penetrate scleral tissue of the eye. The taper angle of the sharpened end can be, for example, about 30°±15° in some embodiments. The radius of the tip can be about 70 to about 200 microns. In other embodiments, where an outlet opening is formed at the distal end of the shunt, the distal portion gradually increases in cross-sectional size in the proximal direction, preferably at a generally constant taper or radius or in a parabolic manner.
The body of the shunt can include at least one surface irregularity. The surface irregularity can comprise, for example, a ridge, groove, relief, hole, or annular groove. The surface discontinuities or irregularities can also be formed by barbs or other projections, which extend from the outer surface of the shunt, to inhibit migration of the shunt from its implanted position. In some embodiments, the projections may comprise external ribbing to resist displacement of the shunt. The surface irregularity in some embodiments can interact with the tissue of the interior wall of the sclera and/or with the tissue of the ciliary attachment tissue. In some embodiments, the shunts are anchored by mechanical interlock between tissue and an irregular surface and/or by friction fit. In other embodiments, the shunt includes cylindrical recessed portions (e.g., annular groves) along an elongate body to provide enhanced gripping features during implantation and anchoring following implantation within the eye tissue.
The shunt may also incorporate fixation features, such as flexible radial (i.e., outwardly extending) extensions. The extensions may be separate pieces attached to the shunt, or may be formed by slitting the shunt wall, and thermally forming or mechanically deforming the extensions radially outward. If the extensions are separate pieces, they may be comprised of flexible material such as nitinol or polyimide. The extensions may be located at the proximal or distal ends of the shunt, or both, to prevent extrusion of the shunt from its intended location. The flexibility of the fixation features will facilitate entry through the corneal incision, and also through the ciliary muscle attachment tissue.
In some embodiments, the body of the shunt has an outlet opening on a side surface to allow fluid flow. In some embodiments, the body of the shunt has a plurality of outlet openings on a side surface to allow fluid flow. In other embodiments, there is a plurality of outlet openings at one end of the shunt, such as the distal end. The openings can facilitate fluid flow through the shunt.
The shunt may have a cap, or tip, at one end. The cap can include a tissue-piercing end and one or more outlet openings. Each of the one or more outlet openings can communicate with at least one of the one or more lumens. In some embodiments the cap can have a conically shaped tip with a plurality of outlet openings disposed proximal of the tip's distal end. In other embodiments, the cap can have a tapered angle tip. The tip can be sufficiently sharp to pierce eye tissue near the scleral spur of the eye. The tip also can be sufficiently blunt so as not to substantially penetrate scleral tissue of the eye. In some embodiments, the conically shaped tip facilitates delivery of the shunt to the desired location. In some embodiments, the cap has an outlet opening on a side surface to allow fluid flow. In some embodiments, the cap has a plurality of outlet openings on a side surface to allow fluid flow. In other embodiments, there is a plurality of outlet openings on the conical surface of the cap. The openings on the cap can facilitate fluid flow through the shunt. The opening may provide an alternate route for fluid flow which is beneficial in case the primary outflow portion of the shunt becomes blocked.
In some embodiments, multiple shunts are configured to be delivered during a single procedure. In some embodiments when multiple shunts are delivered, the shunts are arranged tandemly. The shunt can include a tip protector at one end. The tip protector can comprise a recess shaped to receive and protect, for example, the tip of an adjacent shunt. In some embodiments, the tip of the adjacent shunt has a conical shape. The recess may be shaped to contact the sides of the conical tip while protecting the more tapered tip, or end, from impact. The tip protector is particularly useful for delivery of multiple shunts.
The shunts may be of varied lengths to optimize flows. In some preferred embodiments, the shunt has sufficient length such that the outflow portion resides in the suprachoroidal space and the inflow portion is exposed to the anterior chamber. In other preferred embodiments, the length of the shunt is a length such that the outflow portion resides in the supraciliary space of the uveoscleral outflow pathway. In some embodiments, the length of the shunt is a length such that the outflow portion resides in the membranous region of the uveoscleral outflow pathway adjacent to the retina, while in other embodiments, the shunt has a length that extends distally past the membranous region. In some embodiments, the length of the shunt from the portion residing in the anterior chamber to the portion residing in the uveoscleral outflow pathway may be about 0.5 mm to about 5 mm. In preferred embodiments, the length of the shunt may be about 1.5 mm to about 5 mm. In more preferred embodiments, the length of the shunt may be about 2.0 mm. In some embodiments, the length of the shunt is about 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4.0, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9, or 5.0 mm.
The shunt can have an outer diameter that will permit the shunt to fit within a 23-gauge needle during implantation. The shunt can also have a diameter that is designed to be inserted with larger needles. For example, the shunt can also be delivered with 18-, 19- or 20-gauge needles. In other embodiments, smaller gauge applicators, such as a 23-gauge (or smaller) applicator, may be used. The shunt can have a substantially constant cross-sectional shape through most of the length of the shunt, or the shunt can have portions of reduced or enlarged cross-sectional size (e.g., diameter), or cylindrical channels, e.g., annular grooves, disposed on the outer surface between the proximal end and the distal end. The distal end of the shunt can have a tapered portion, or a portion having a continually decreasing radial dimension with respect to the lumen axis along the length of the axis. The tapered portion preferably in some embodiments terminates with a smaller radial dimension at the outflow end. During implantation, the tapered portion can operate to form, dilate, and/or increase the size of, an incision or puncture created in the tissue. The tapered portion may have a diameter of about 23 gauge to about 30 gauge, and preferably about 25 gauge.
The diameter of one or more drainage lumens within the shunt may be varied to alter flow characteristics. The cross-sectional size of a shunt may be, for example, 0.1 mm to about 1.0 mm, or preferably about 0.3 mm to about 0.4 mm. A small cross-sectional size can be used to restrict flow. The cross-sectional shape of the shunt or a shunt may be any of a variety of cross-sectional shapes suitable for allowing fluid flow. For example, the cross-sectional shape of the shunt or shunt may be circular, oval, square, trapezoidal, rectangular, or any combination thereof.
In some embodiments, the shunt is configured to expand, either radially or axially, or both radially and axially. In some embodiments, the shunt may be self-expanding. In other embodiments, the shunt may be expanded by, for example, using a balloon device.
The structure of the shunt may be flexible. At least a portion of the structure of the shunt may be flexible, or the whole structure may be flexible. In some embodiments, the structure of the shunt is accordion- or balloon-like. This pleated like structure provides flexibility. In other embodiments, at least a portion of the shunt is curved. In some embodiments, at least a portion of the shunt is straight. In some embodiments, the shunt has both curved and straight portions, and in some embodiments, the shunt is generally rigid (i.e., maintains its preformed shape when implanted).
The shunt is preferably made of one or more biocompatible materials. Suitable biocompatible materials include polypropylene, polyimide, glass, nitinol, polyvinyl alcohol, polyvinyl pyrrolidone, collagen, chemically-treated collagen, polyethersulfone (PES), poly(styrene-isobutyl-styrene), Pebax, acrylic, polyolefin, polysilicon, polypropylene, hydroxyapatite, titanium, gold, silver, platinum, other metals, ceramics, plastics and a mixture thereof. The shunts can be manufactured by conventional sintering, micro machining, laser machining, and/or electrical discharge machining.
In some embodiments, the shunt is made of a flexible material. In other embodiments, the shunt is made of a rigid material. In some embodiments, a portion of the shunt is made from flexible material while another portion of the shunt is made from rigid material. The body can have an outer surface of which at least a portion is porous. Some embodiments include porosity that can be varied by masking a portion of the exterior with a band. Where the shunts include a porous body, the cross-section and porosity can be calibrated (down to 0.5 micrometers) to control the flow rates of aqueous humor through the shunt.
In some embodiments, at least a portion of the shunt (e.g., an internal spine or an anchor) is made of a material capable of shape memory. A material capable of shape memory may be compressed and, upon release, may expand axially or radially, or both axially and radially, to assume a particular shape. In some embodiments, at least a portion of the shunt has a preformed shape. In other embodiments, at least a portion of the shunt is made of a superelastic material. In some embodiments, at least a portion of the shunt is made up nitinol. In other embodiments, at least a portion of the shunt is made of a deformable material.
The body of the shunt can comprise material that includes a therapeutic agent, and/or can house, anchor, or support a therapeutic agent, or can include a coating. The coating can include a therapeutic agent. The coatings can be, for example, a drug eluting coating, an antithrombogenic coating, and a lubricious coating. The therapeutic agent can be selected from the group consisting of: heparin, TGF-beta, an intraocular pressure-lowering drug, and an anti-proliferative agent. Materials that may be used for a drug-eluting coating include parylene C, poly (butyl methacrylate), poly (methyl methacrylate), polyethylene-co-vinyl acetate, and other materials known in the art.
The shunt can further comprise a biodegradable material in or on the shunt. The biodegradable material can be selected from the group consisting of poly(lactic acid), polyethylene-vinyl acetate, poly(lactic-co-glycolic acid), poly(D,L-lactide), poly(D,L-lactide-co-trimethylene carbonate), collagen, heparinized collagen, poly(caprolactone), poly(glycolic acid), and a copolymer. All or a portion of the shunt may be coated with a therapeutic agent, e.g. with heparin, preferably in the flow path, to reduce blood thrombosis or tissue restenosis.
The flow path through the shunt can be configured to be regulated to a flow rate that will reduce the likelihood of hypotony in the eye. In some embodiments, the intraocular pressure is maintained at about 8 mm Hg. In other embodiments, the intraocular pressure is maintained at pressures less than about 8 mmHg, for example the intraocular pressure may be maintained between about 6 mm Hg and about 8 mm Hg. In other embodiments, the intraocular pressure is maintained at pressures greater than about 8 mm Hg. For example, the pressures may be maintained between about 8 mmHg and about 18 mm Hg, and more preferably between 8 mm Hg and 16 mm Hg, and most preferably not greater than 12 mm Hg. In some embodiments, the flow rate can be limited to about 2.5 μL/min or less. In some embodiments the flow rate can be limited to between about 1.9 μL/min and about 3.1 μL/min.
For example, the Hagen-Poiseuille equation suggests that a 4 mm long stent at a flow rate of 2.5 μL/min should have an inner diameter of 52 mm to create a pressure gradient of 5 mm Hg above the pressure in the suprachoroidal space.
The shunt may or may not comprise means for regulating fluid flow through the shunt. Means for regulating fluid flow can include flow restrictors, pressure regulators, or both. Alternatively, in some embodiments the shunt has neither a flow restrictor nor a pressure regulator. Regulating flow of aqueous humor can comprise varying between at least first and second operational states in which aqueous humor flow is more restricted in a first state and less restricted in a second state. Increasing the restriction to flow when changing from the second state to the first state can involve moving a valve toward a valve seat in a direction generally parallel or generally normal to a line connecting the proximal and distal ends of the shunt.
As noted above, the outflow portion of the shunt, in some embodiments is sized and configured to reside in the supraciliary region of the uveoscleral outflow pathway. In such embodiments, there is a lesser need for means for regulating fluid flow through the shunt.
The means for flow restriction may be, for example, a valve, a long lumen length, small lumen cross section, or any combination thereof. In some embodiments, the flow of fluid is restricted by the size of a lumen within the shunt, which produces a capillary effect that limits the fluid flow for given pressures. The capillary effect of the lumen allows the shunt to restrict flow and provides a valveless regulation of fluid flow.
The flow path length may be increased without increasing the overall length of the shunt by creating a lumen with a spiral flow path. A lumen within the shunt is configured to accommodate placement therein of a spiral flow channel core that is configured to provide preferred flow restriction. In effect, the spiral flow channel provides an extended path for the flow of fluid between the inlet(s) and outlet(s) of the shunt that is greater than a straight lumen extending between the ends of the shunt. The extended path provides a greater potential resistance of fluid flow through the shunt without increasing the length of the shunt. The core could have a single spiral flow channel, or a plurality of spiral flow channels for providing a plurality of flow paths through which fluid may flow through the shunt. For example, the core can have two or more spiral flow channels, which can intersect.
In some embodiments, the means for flow regulation comprises a pressure regulating valve. The valve can open when fluid pressure within the anterior chamber exceeds a preset level. Intraocular pressure may be used to apply a force to move a valve surface within the shunt in a direction transverse to a longitudinal axis of the shunt such that aqueous humor flows from the anterior chamber to the uveoscleral outflow pathway at intraocular pressures greater than a threshold pressure.
A shunt may have any number of valves to restrict flow and/or regulate pressure. The valve is preferably located between the anterior chamber and one or more effluent openings such that movement of the valve regulates flow from the interior chamber to the one or more effluent openings. A variety of valves are useful with the shunt for restricting flow. In some embodiments, the valve is a unidirectional valve and/or is a pressure relief valve. The pressure relief valve can comprise a ball, a ball seat and a biasing member urging the ball towards the ball seat. In some embodiments, the valve is a reed-type valve. In a reed valve, for example, one end of the valve may be fixed to a portion of the shunt. The body of the reed valve is capable of being deflected in order to allow flow. Pressure from fluid in the anterior chamber can deflect the body of the reed valve, thereby causing the valve to open.
In some embodiments, the shunt includes a pressure regulation valve having a deflectable plate or diaphragm with a surface area exposed to fluid within the interior chamber, the surface area being substantially greater than the total cross-sectional flow area of the one or more influent openings of the shunt. Such a valve can be disposed between an interior chamber of the shunt and the one or more effluent openings such that movement of the deflectable plate regulates flow from the interior chamber to the one or more effluent openings. The plate can extend in a direction generally parallel to the inlet flow path and to the outlet flow path.
When the intraocular pressure exceeds a particular pressure, the check pressure relief valve will open and permit fluid to flow between the anterior chamber and the uveoscleral outflow pathway. When the intraocular pressure reaches a second, lower pressure, the valve will close and limit or inhibit fluid from being conducted to the suprachoroidal space. The valve will remain closed until the intraocular pressure again reaches the particular pressure, and at which time the valve will reopen to permit or enhance drainage of fluid to the uveoscleral outflow pathway. Accordingly, the shunt provides drainage of the anterior chamber through the shunt based on the intraocular pressure levels and reduces the likelihood for over-draining the anterior chamber and causing hypotony.
Delivery Instruments
Another aspect of the systems and methods described herein relates to delivery instruments for implanting a shunt for draining fluid from the anterior chamber into a physiologic outflow space. In some embodiments, the shunt is inserted from a site transocularly situated from the implantation site. The delivery instrument can be sufficiently long to advance the shunt transocularly from the insertion site across the anterior chamber to the implantation site. At least a portion of the instrument can be flexible. Alternatively, the instrument can be rigid. The instrument can comprise a plurality of members longitudinally moveable relative to each other. In some embodiments, at least a portion of the delivery instrument is curved or angled. In some embodiments, a portion of the delivery instrument is rigid and another portion of the instrument is flexible.
In some embodiments, the delivery instrument has a distal curvature. The distal curvature of the delivery instrument may be characterized as a radius of approximately 10 to 30 mm, and preferably about 20 mm.
In some embodiments, the delivery instrument has a distal angle. The distal angle may be characterized as approximately 90 to 170 degrees relative to an axis of the proximal segment of the delivery instrument, and preferably about 145 degrees. The angle can incorporate a small radius of curvature at the “elbow” so as to make a smooth transition from the proximal segment of the delivery instrument to the distal segment. The length of the distal segment may be approximately 0.5 to 7 mm, and preferably about 2 to 3 mm.
In some embodiments, the instruments have a sharpened forward end and are self-trephinating, i.e., self-penetrating, so as to pass through tissue without pre-forming an incision, hole or aperture. Alternatively, a trocar, scalpel, or similar instrument can be used to pre-form an incision in the eye tissue before passing the shunt into such tissue.
For delivery of some embodiments of the ocular shunt, the instrument can have a sufficiently small cross section such that the insertion site self seals without suturing upon withdrawal of the instrument from the eye. An outer diameter of the delivery instrument preferably is no greater than about 18 gauge and is not smaller than about 27 gauge.
For delivery of some embodiments of the ocular shunt, the incision in the corneal tissue is preferable made with a hollow needle through which the shunt is passed. The needle has a small diameter size (e.g., 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25 or 26 or 27 gauge) so that the incision is self sealing and the implantation occurs in a closed chamber with or without viscoelastic. A self-sealing incision also can be formed using a conventional “tunneling” procedure in which a spatula-shaped scalpel is used to create a generally inverted V-shaped incision through the cornea. In a preferred mode, the instrument used to form the incision through the cornea remains in place (that is, extends through the corneal incision) during the procedure and is not removed until after implantation. Such incision-forming instrument either can be used to carry the ocular shunt or can cooperate with a delivery instrument to allow implantation through the same incision without withdrawing the incision-forming instrument. Of course, in other modes, various surgical instruments can be passed through one or more corneal incisions multiple times.
Once into the anterior chamber, a delivery instrument can be advanced from the insertion site transocularly into the anterior chamber angle and positioned at a location near the scleral spur. Using the scleral spur as a reference point, the delivery instrument can be advanced further in a generally posterior direction to drive the shunt into eye tissue at a location just inward of the scleral spur toward the iris. The placement and implantation of the shunt can be performed using a gonioscope or other conventional imaging equipment. The delivery instrument preferably is used to force the shunt into a desired position by application of a continual implantation force, by tapping the shunt into place using a distal portion of the delivery instrument, or by a combination of these methods. Once the shunt is in the desired position, it may be further seated by tapping using a distal portion of the delivery instrument.
The delivery instrument can include an open distal end with a lumen extending therethrough. Positioned within the lumen is preferably a pusher tube that is axially movable within the lumen. The pusher tube can be any device suitable for pushing or manipulating the shunt in relation to the delivery instrument, such as, for example, but without limitation a screw, a rod, a stored energy device such as a spring. A wall of the delivery instrument preferably extends beyond pusher tube to accommodate placement within the lumen of a shunt. The shunt can be secured in position. For example, the shunt can be secured by viscoelastic or mechanical interlock with the pusher tube or wall. When the shunt is brought into position adjacent the tissue in the anterior chamber angle, the pusher tube is advanced axially toward the open distal end of the delivery instrument. As the pusher tube is advanced, the shunt is also advanced. When the shunt is advanced through the tissue and such that it is no longer in the lumen of the delivery instrument, the delivery instrument is retracted, leaving the shunt in the eye tissue.
Some embodiments can include a spring-loaded or stored-energy pusher system. The spring-loaded pusher preferably includes a button operably connected to a hinged rod device. The rod of the hinged rod device engages a depression in the surface of the pusher, keeping the spring of the pusher in a compressed conformation. When the user pushes the button, the rod is disengaged from the depression, thereby allowing the spring to decompress, thereby advancing the pusher forward.
In some embodiments, an over-the wire system is used to deliver the shunt. The shunt can be delivered over a wire. Preferably, the wire is self-trephinating. The wire can function as a trocar. The wire can be superelastic, flexible, or relatively inflexible with respect to the shunt. The wire can be pre-formed to have a certain shape. The wire can be curved. The wire can have shape memory, or be elastic. In some embodiments, the wire is a pull wire. The wire can be a steerable catheter.
In some embodiments, the wire is positioned within a lumen in the shunt. The wire can be axially movable within the lumen. The lumen may or may not include valves or other flow regulatory devices.
In some embodiments, the delivery instrument comprises is a trocar. The trocar may be angled or curved. The trocar can be rigid, semi-rigid or flexible. In embodiments where the trocar is stiff, the shunt can be, but need not be relatively flexible. The diameter of the trocar can be about 0.001 inches to about 0.01 inches. In some embodiments, the diameter of the trocar is 0.001, 0.002, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, or 0.01 inches.
In some embodiments, delivery of the shunt is achieved by applying a driving force at or near the distal end of the shunt. The driving force can be a pulling or a pushing applied generally to the end of the shunt.
The instrument can include a seal to prevent aqueous humor from passing through the delivery instrument and/or between the members of the instrument when the instrument is in the eye. The seal can also aid in preventing backflow of aqueous humor through the instrument and out the eye. Suitable seals for inhibiting leakage include, for example, an o-ring, a coating, a hydrophilic agent, a hydrophobic agent, and combinations thereof. The coating can be, for example, a silicone coat such as MDX™ silicone fluid. In some embodiments, the instrument is coated with the coating and a hydrophilic or hydrophobic agent. In some embodiments, one region of the instrument is coated with the coating plus the hydrophilic agent, and another region of the instrument is coated with the coating plus the hydrophobic agent. The delivery instrument can additionally comprise a seal between various members comprising the instrument. The seal can comprise a hydrophobic or hydrophilic coating between slip-fit surfaces of the members of the instrument. The seal can be disposed proximate of the drainage shunt when carried by the delivery instrument. Preferably, the seal is present on at least a section of each of two devices that are machined to fit closely with one another.
In some embodiments, the delivery instrument can include a distal end having a beveled shape. The delivery instrument can include a distal end having a spatula shape. The beveled or spatula shape can have a sharpened edge. The beveled or spatula shape can include a recess to contain the shunt. The recess can include a pusher or other suitable means to push out or eject the shunt.
The delivery instrument further can be configured to deliver multiple shunts. In some embodiments, when multiple shunts are delivered, the shunts can be arranged in tandem, as described in greater detail below.
Procedures
For delivery of some embodiments of the ocular shunt, the implantation occurs in a closed chamber with or without viscoelastic.
The shunts may be placed using an applicator, such as a pusher, or they may be placed using a delivery instrument having energy stored in the instrument, such as disclosed in U.S. Patent Publication 2004/0050392, filed Aug. 28, 2002, the entirety of which is incorporated herein by reference and made a part of this specification and disclosure. In some embodiments, fluid may be infused through the delivery instrument or another instrument used in the procedure to create an elevated fluid pressure at the distal end of the shunt to ease implantation.
In some embodiments, the shunt is implanted through the fibrous attachment of the ciliary muscle to the sclera. This fibrous attachment zone extends about 0.5 mm posteriorly from the scleral spur, as shown between the two arrows (1020) in
In some embodiments it is desirable to deliver the shunt ab interno across the eye, through a small incision at or near the limbus (
In some embodiments, during clinical use, the shunt and delivery instrument can be advanced together through the anterior chamber 32 from an incision at or near the limbus, across the iris, and through the ciliary muscle attachment until the shunt outlet portion is located in the uveoscleral outflow pathway (e.g. exposed to the suprachoroidal space 34 defined between the sclera 38 and the choroid 40).
In some embodiments, a viscoelastic can be injected into the suprachoroidal space to create a chamber or pocket between the choroid and sclera which can be accessed by a shunt. Such a pocket could expose more of the choroidal and scleral tissue area, and increase uveoscleral outflow, causing a lower TOP. In some embodiments, the viscoelastic material can be injected with a 25 or 27 G cannula, for example, through an incision in the ciliary muscle attachment or through the sclera (e.g. from outside the eye). The viscoelastic material can also be injected through the shunt itself either before, during or after implantation is completed.
In some embodiments, a hyperosmotic agent can be injected into the suprachoroidal space. Such an injection can delay TOP reduction. Thus, hypotony can be avoided in the acute postoperative period by temporarily reducing choroidal absorption. The hyperosmotic agent can be, for example glucose, albumin, HYPAQUE™ medium, glycerol, or poly(ethylene glycol). The hyperosmotic agent can breakdown or wash out as the patient heals, resulting in a stable, acceptably low TOP, and avoiding transient hypotony.
Therapeutic Agents
The therapeutic agents that may be utilized with the ophthalmic implant system may include one or more agents provided below. The therapeutic agents include but are not limited to pharmaceutical agents, biological agents including hormones, enzyme or antibody-related components, oligonucleotides, DNA/RNA vectors and live cells configured to produce one or more biological components. The use of any particular therapeutic agent is not limited to their primary effect or regulatory body-approved treatment indication or manner of use. The listing of any particular agent within any one therapeutic class below is only representative of one possible use of the agent and is not intended to limit the scope of its use with the ophthalmic implant system. Exemplary therapeutic agents may include: anti-angiogenesis agents, including VEGF receptor tyrosine kinase inhibitors and anti-vascular endothelial growth factor (anti-VEGF) agents such as ranibizumab (LUCENTIS®) and bevacizumab (AVASTIN®), pegaptanib (MACUGEN®), sunitinib and sorafenib and any of a variety of known small-molecule and transcription inhibitors having anti-angiogenesis effect; classes of known ophthalmic agents, including: glaucoma agents, such as beta-blocker agents such as betaxolol, carteolol, levobetaxolol, levobunolol and timolol; carbonic anhydrase inhibitor agents such as acetozolamide, brinzolamide, dorzolamide and methazolamide; mydriatic-cycloplegic agents such as atropine, cyclopentolate, succinylcholine, homatropine, phenylephrine scopolamine and tropicamide; prostaglandin analog agents such as bimatoprost, latanoprost, travoprost and unopro stone; sympathomimetic agents such as apraclonidine, brimonidine and dipivefrin; corticosteroidal and non-steroidal anti-inflammatory agents such as beclomethasone, budesonide, dexamethasone, diclofenac, flunisolide, fluorometholone, fluticasone, ketorolac, hydrocortisone, loteprednol, prednisolone, rimexolone and triamcinolone; anti-infective agents such as aminoglycosides such as gentamicin and tobramycin; fluoroquinolones such as ciprofloxacin, gatifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin; bacitracin, erythromycin, fusidic acid, neomycin, polymyxin B, gramicidin, trimethoprim and sulfacetamide; anti-histamine agents such as azelastine, emedastine and levocabastine; MAST cells stabilizer agents such as cromolyn sodium, ketotifen, lodoxamide, nedocrimil, olopatadine and pemirolastciliary body ablative agents, such as the aformentioned gentimicin and cidofovir; and other ophthalmic agents such as verteporfin, proparacaine, tetracaine, cyclosporine and pilocarpine.
Other therapeutic agents of the same class as the ophthalmic agents listed above that may be used include: other beta-blocker agents such as acebutolol, atenolol, bisoprolol, carvedilol, asmolol, labetalol, nadolol, penbutolol, pindolol and propranolol; other corticosteroidal and non-steroidal anti-inflammatory agents such aspirin, betamethasone, cortisone, diflunisal, etodolac, fenoprofen, fludrocortisone, flurbiprofen, hydrocortisone, ibuprofen, indomethacine, ketoprofen, meclofenamate, mefenamic acid, meloxicam, methylprednisolone, nabumetone, naproxen, oxaprozin, prednisolone, prioxicam, salsalate, sulindac and tolmetin; COX-2 inhibitors like celecoxib, rofecoxib and. Valdecoxib; other immune-modulating agents such as aldesleukin, adalimumab (HUMIRA®), azathioprine, basiliximab, daclizumab, etanercept (ENBREL®), hydroxychloroquine, infliximab (REMICADE®), leflunomide, methotrexate, mycophenolate mofetil, and sulfasalazine; other anti-histamine agents such as loratadine, desloratadine, cetirizine, diphenhydramine, chlorpheniramine, dexchlorpheniramine, clemastine, cyproheptadine, fexofenadine, hydroxyzine and promethazine; other anti-infective agents such as aminoglycosides such as amikacin and streptomycin; anti-fungal agents such as amphotericin B, caspofungin, clotrimazole, fluconazole, itraconazole, ketoconazole, voriconazole, terbinafine and nystatin; anti-malarial agents such as chloroquine, atovaquone, mefloquine, primaquine, quinidine and quinine; anti-mycobacterium agents such as ethambutol, isoniazid, pyrazinamide, rifampin and rifabutin; anti-parasitic agents such as albendazole, mebendazole, thiobendazole, metronidazole, pyrantel, atovaquone, iodoquinaol, ivermectin, paromycin, praziquantel, and trimatrexate; other anti-viral agents, including anti-CMV or anti-herpetic agents such as acyclovir, cidofovir, famciclovir, gangciclovir, valacyclovir, valganciclovir, vidarabine, trifluridine and foscarnet; protease inhibitors such as ritonavir, saquinavir, lopinavir, indinavir, atazanavir, amprenavir and nelfinavir; nucleotide/nucleoside/non-nucleoside reverse transcriptase inhibitors such as abacavir, ddI, 3TC, d4T, ddC, tenofovir and emtricitabine, delavirdine, efavirenz and nevirapine; other anti-viral agents such as interferons, ribavirin and trifluridiene; other anti-bacterial agents, including cabapenems like ertapenem, imipenem and meropenem; cephalosporins such as cefadroxil, cefazolin, cefdinir, cefditoren, cephalexin, cefaclor, cefepime, cefoperazone, cefotaxime, cefotetan, cefoxitin, cefpodoxime, cefprozil, ceftaxidime, ceftibuten, ceftizoxime, ceftriaxone, cefuroxime and loracarbef; other macrolides and ketolides such as azithromycin, clarithromycin, dirithromycin and telithromycin; penicillins (with and without clavulanate) including amoxicillin, ampicillin, pivampicillin, dicloxacillin, nafcillin, oxacillin, piperacillin, and ticarcillin; tetracyclines such as doxycycline, minocycline and tetracycline; other anti-bacterials such as aztreonam, chloramphenicol, clindamycin, linezolid, nitrofurantoin and vancomycin; alpha blocker agents such as doxazosin, prazosin and terazosin; calcium-channel blockers such as amlodipine, bepridil, diltiazem, felodipine, isradipine, nicardipine, nifedipine, nisoldipine and verapamil; other anti-hypertensive agents such as clonidine, diazoxide, fenoldopan, hydralazine, minoxidil, nitroprus side, phenoxybenzamine, epoprostenol, tolazoline, treprostinil and nitrate-based agents; anti-coagulant agents, including heparins and heparinoids such as heparin, dalteparin, enoxaparin, tinzaparin and fondaparinux; other anti-coagulant agents such as hirudin, aprotinin, argatroban, bivalirudin, desirudin, lepirudin, warfarin and ximelagatran; anti-platelet agents such as abciximab, clopidogrel, dipyridamole, optifibatide, ticlopidine and tirofiban; prostaglandin PDE-5 inhibitors and other prostaglandin agents such as alprostadil, carboprost, sildenafil, tadalafil and vardenafil; thrombolytic agents such as alteplase, anistreplase, reteplase, streptokinase, tenecteplase and urokinase; anti-proliferative agents such as sirolimus, tacrolimus, everolimus, zotarolimus, paclitaxel and mycophenolic acid; hormonal-related agents including levothyroxine, fluoxymestrone, methyltestosterone, nandrolone, oxandrolone, testosterone, estradiol, estrone, estropipate, clomiphene, gonadotropins, hydroxyprogesterone, levonorgestrel, medroxyprogesterone, megestrol, mifepristone, norethindrone, oxytocin, progesterone, raloxifene and tamoxifen; anti-neoplastic agents, including alkylating agents such as lomustine, melphalan and procarbazine antibiotic-like agents such as bleomycin, daunorubicin, doxorubicin, idarubicin, mitomycin and plicamycin; antimetabolite agents such as cytarabine, fludarabine, hydroxyurea, mercaptopurine and 5-fluorouracil (5-FU); immune modulating agents such as aldesleukin, imatinib, rituximab and tositumomab; mitotic inhibitors docetaxel, etoposide, vinblastine and vincristine; radioactive agents such as strontium-89; and other anti-neoplastic agents such as irinotecan, topotecan and mitotane.
The therapeutic agents may be released or eluted from the ophthalmic implant system, bound to a surface of the ophthalmic implant, and/or used in conjunction with the ophthalmic implant through injection, oral or eye drop delivery routes. The therapeutic agents may also be released from a separate drug eluting device that is implantable in the same or a different location in the eye or orbital cavity. The separate drug eluting device may be located in a physiologic outflow pathway or physiologic cavity of the eye or body, or may be implanted into an artificially formed site of the eye or body. A variety of controlled-release technologies that are known in the art may be used with the ophthalmic implant system, including non-degradable and biodegradable polymeric and non-polymeric release platforms.
Injection/infusion/implantation routes or sites include intravenous and intravitreal routes, choroidal, scleral, conjunctival, retinal, ciliary body, posterior chamber, anterior chamber (including the angle), trabecular meshwork, Schlemm's canal, suprachoroidal, and other sites along the uveoscleral pathway. The vascular routes or sites include but are not limited to the ophthalmic artery, the lacrimal artery, the short posterior ciliary arteries, the long posterior ciliary arteries, the anterior ciliary arteries, the central retinal arteries, the central retinal veins, and episcleral arteries and veins.
In some embodiments, combinations of agents having synergistic and/or complementary effects for a particular disease or set of related conditions or symptoms may be used. In one example, a disease-treating agent may be used in combination with a metabolism-altering agent affecting the cytochrome P450 system to affect the pharmacokinetics of the disease-treating agent. In another example, an anti-infective agent may be combined with an anti-inflammatory agent to treat inflammation resulting from the infection.
Embodiments Illustrated in
The shunt 130 preferably has an outer diameter that will permit the shunt 130 to fit within a 21-gauge or 23-gauge needle or hollow instrument during implantation; however, larger or smaller gauge instruments may also be used. The shunt 130 can also have a diameter that is designed to be delivered with larger needles. For example, the shunt 130 can also be delivered with 18-, 19- or 20-gauge needles. The shunt 130 can have a constant diameter through most of the length of the shunt 130, or the shunt 130 can have portions of reduced diameter, e.g., annular grooves 146, between the proximal end 138 and the distal end 140. The annular grooves 146 produce an irregular outer surface that can operate to mechanically lock or anchor the shunt 130 in place when implanted. Of course, such surface discontinuities or irregularities can also be formed by barbs or other projections, which extend from the outer surface of the shunt, to inhibit migration of the shunt 130 from its implanted position, as described above.
The outflow portion 134 of the shunt 130 preferably is disposed at or near the distal end 140 of the shunt 130. In the illustrated embodiment, the outflow portion 134 has a tapered portion 144; however, it may also have other shapes (e.g. semi-sphere, a paraboloid, a hyperboloid) with a continually decreasing radial dimension with respect to the lumen axis 142 along the length of the axis 142. The tapered portion 144 preferably terminates with a smaller radial dimension at the outflow end 140. During implantation, the tapered portion 144 can operate to form, dilate, and/or increase the size of, an incision or puncture created in the tissue. For example, the distal end 140 can operate as a trocar to puncture or create an incision in the tissue. Following advancement of the distal end 140 of the shunt 130, the tapered portion 144 can be advanced through the puncture or incision. The tapered portion 144 will operate to stretch or expand the tissue around the puncture or incision to accommodate the increasing size of the tapered portion 144 as it is advanced through the tissue. When the stretched tissue passes over the cylindrical channels 146 having a reduced diameter, the stretched tissue will retract generally to fill the cylindrical channels 146 and will abut the edges of the shunt 130 having a greater diameter. The interaction of the tissue and the edges of the shunt 130 will provide an anchor for the shunt 130 following implantation to inhibit shunt migration.
The tapered portion 144 can also facilitate proper location of the shunt 130 into the supraciliary or suprachoroidal spaces. For example, the shunt 130 is preferably advanced through the tissue within the anterior chamber angle during implantation. This tissue typically is fibrous or porous, which is relatively easy to pierce or cut with a surgical device, such as the tip of the shunt 130. The shunt 130 can be advanced through this tissue and abut against the sclera once the shunt extends into the uveoscleral outflow pathway. As the shunt 130 abuts against the sclera, the tapered portion 144 preferably provides a generally rounded edge or surface that facilitates sliding of the shunt 130 within the suprachoroidal space along the interior wall of the sclera. For example, as the shunt 130 is advanced into the uveoscleral outflow pathway and against the sclera, the shunt 130 will likely be oriented at an angle with respect to the interior wall of the sclera. As the tip of the shunt 130 engages the sclera, the tip preferably has a radius that will permit the shunt 130 to slide along the sclera instead of piercing or substantially penetrating the sclera. As the shunt 130 slides along the sclera, the tapered portion 144 will provide an edge against which the shunt 130 can abut against the sclera and reduce the likelihood that the shunt will pierce the sclera.
Once the shunt 130 is implanted in position with the inflow portion 132 residing in the anterior chamber and the outflow portion 134 residing in the uveoscleral outflow pathway, aqueous humor flows from the anterior chamber to the uveoscleral outflow pathway through the lumen 136 of the shunt. The flow of fluid is preferably restricted by the size of the lumen 136, which produces a capillary effect that limits the fluid flow for given pressures. The capillary effect of the lumen allows the shunt to restrict flow and provides a valveless regulation of fluid flow. The flow of fluid through the shunt 130 is preferably configured to be restricted to flow rated that will reduce the likelihood of hypotony in the eye. For example, in some embodiments, the flow rate can be limited to about 2.5 μL/min or less. In some embodiments the flow rate can be limited to between about 1.9 μL/min and about 3.1 μL/min. In other applications, a plurality of shunts 130 can be used in a single eye to conduct fluid from the anterior chamber to the uveoscleral outflow pathway. In such applications, the cumulative flow rate through the shunts preferably is within the range of about 1.9 μL/min to about 3.1 μL/min, although the flow rate for each of the shunts can be significantly less than about 2.5 μL/min. For example, if an application called for implantation of five shunts, then each shunt 130 can be configured to have a flow rate of about 0.5 μL/min.
While the lumen is depicted in
The shunt 130 preferably comprises any of the materials previously described above. The shunt 130 can be fabricated through conventional micro machining techniques or through procedures commonly used for fabricating optical fibers. For example, in some embodiments, the shunts 130 are drawn with a bore, or lumen, extending therethrough. In some embodiments, the tapered portion 144 at the outflow portion 134 can be constructed by shearing off an end tubular body. This can create a tapered portion 144 that can be used to puncture or incise the tissue during implantation and dilate the puncture or incision during advancement of the shunt 130. Other materials can be used for the shunt of
The shunt 130 of
Embodiments Illustrated in
Additional embodiments of shunts are depicted in
The shunts depicted in
Embodiments Illustrated in
Proximate the outflow end 440 is preferably a tapered portion 444 that decreases in a radial dimension along a lumen axis 442. In some embodiments, the shunt 430 includes cylindrical recessed portions 446 along the elongate body to provide enhanced gripping features during implantation and anchoring following implantation within the eye tissue. The lumen 436 is preferably configured to accommodate placement therein of a spiral flow channel core 448 that is configured to provide preferred flow restriction.
The core 448 is preferably configured to extend through the lumen 436 between the inflow end 438 and the outflow end 440 and includes a tortuous or spiral flow channel 450 extending generally along the exterior of the core 448. In effect, the spiral flow channel 450 provides an extended path for the flow of fluid between the two ends of the shunt 430 that is greater than a straight lumen extending between the ends of the shunt 430. The extended path provides a greater potential resistance of fluid flow through the shunt without increasing the length of the shunt.
While the core 448 is depicted in
The shunt 430 is preferably manufactured of metals, ceramics, or plastics through conventional micro machining, laser machining, or electrical discharge machining. For example, the shunt 430 can be constructed of titanium, glass, or noble metals. In some embodiments, the core 448 is made of the same material as the body of the shunt 430 while in yet further embodiments, the core 448 includes a material that is different than the body of the shunt 430.
Embodiments Illustrated in
The shunt 530 is preferably configured to conduct fluid between the anterior chamber and the uveoscleral outflow pathway with the inflow end 538 exposed to the anterior chamber and the outflow end 540 exposed to the suprachoroidal space. The shunt 530 preferably reduces the likelihood of hypotony of the eye by providing a ball-check pressure regulator. For example, when the intraocular pressure exceeds a particular pressure, the ball-check pressure regulator will open and permit fluid to flow between the anterior chamber and the uveoscleral outflow pathway. When the intraocular pressure reaches a second, lower pressure, the ball-check pressure regulator will close and limit or inhibit fluid from being conducted to the uveoscleral outflow pathway. The ball-check pressure regulator will remain closed until the intraocular pressure again reaches the particular pressure, and at which time the ball-check valve will reopen to permit or enhance drainage of fluid to the uveoscleral outflow pathway. Accordingly, the shunt 530 provides drainage of the anterior chamber through the shunt 530 based on the intraocular pressure levels and reduces the likelihood for over-draining the anterior chamber and causing hypotony.
The ball-check regulator is preferably configured to be positioned within the lumen 536 of the shunt 530 and includes a luminal spring 552 that is configured to reside within the lumen. The luminal spring 552 is depicted as a coil spring, but the luminal spring 552 can be any type of spring or biasing member that is resilient or reversibly compressible. For example, the spring 552 can comprise Nitinol or other flexible or resilient materials. The ball-check regulator also preferably includes a ball 554 that preferably has a diameter less than the diameter of the lumen 536 of the shunt 530 so as to permit movement of the ball 554 within the lumen 536 and to permit the flow of fluid between the ball 554 and the inner wall of the lumen 536 when the ball 554 resides within the lumen 536. The luminal spring 552 is preferably configured to engage a ball 554 at one end of the luminal spring 552 and to permit the ball 554 to move between different positions within the lumen 536.
A ball sleeve 556 is preferably provided within at least a portion of the lumen 536 and is positioned adjacent to the ball 554 opposite the luminal spring 552. For example,
The shunt 530 also preferably includes a distal taper or cone 560 that is configured to reside at least partially within the lumen 536. The distal cone 560 preferably includes radial flanges 562 that provide a means for securing the cone 560 in place by engaging the inner wall of the lumen 536 while providing a space between the distal cone 560 and the inner wall of the lumen 536. In some embodiments, the distal cone 560 provides radial channels 562 instead of flanges through which the fluid can be conducted. The space between the inner wall of the lumen 536 and the cone 560 or the channels 562 permits fluid conducted through the lumen 536 to exit the shunt by flowing around the distal cone 560.
When the ball-check pressure regulator is assembled, the luminal spring 552 is preferably seated against the distal cone 560 on one end and presses against the ball 554 on the other end with a determined force. The ball 554 is moved against the ball seat 558 of the ball sleeve 556 as a reaction to the force of the luminal spring 552. When the shunt 530 is inserted within the eye with the inflow end 538 exposed to the anterior chamber and the outflow end 540 exposed to the suprachoroidal space, the ball 554 will be exposed to the intraocular pressure of the anterior chamber. The ball 554 will be pressed against the ball seat 558 and limit or inhibit flow of fluid past the ball 554 until the intraocular pressure exerts a force upon the ball 554 that is greater than the force applied by the luminal spring 552. When the luminal spring 552 force is overpowered by the intraocular pressure, the ball 554 will be moved down the lumen 536 away from the ball seat 558, thus permitting fluid to pass around the ball 554, through the lumen 536, and out the outflow portion 534 between the radial flanges 562 of the distal cone 560. When the intraocular pressure drops, the force pressing against the ball 554 will be reduced, and when the force applied on the ball 554 by the intraocular pressure is less than the force applied on the ball 554 by the luminal spring 552, the ball 554 will be moved through the lumen 536 until it is pressed against the ball seat 558, thus stopping the flow of fluid through the lumen 536.
Embodiments Illustrated in
A flexible or resilient middle portion 646 is preferably positioned between the two portions 642, 644. The middle portion 646 is preferably a biased membrane that is biased toward the bottom portion 644 when the shunt 630 is assembled and rests on a membrane seat 654. A plurality of apertures 653 along the edges of the membrane preferably coincides with a plurality of protrusions 655 on the top and bottom portions 642, 644. When the shunt 630 is assembled, the interlocking protrusions 655 and apertures 653 create a seal that reduces the likelihood of fluid from leaking from the chamber 650. The middle portion 646 is preferably constructed of a nitinol sputter deposited silicone membrane. The membrane preferably pressed against the bottom portion 644 and has an aperture 656 extending therethrough. The aperture 656 provides a flow path through which fluid conducted through the shunt 630 can pass when the membrane does not rest on the membrane seat 654.
In operation, the shunt is inserted into the eye with the inflow portion 632 exposed to the anterior chamber and the outflow portion 634 exposed to the uveoscleral outflow pathway. Fluid from the anterior chamber will enter into the inflow apertures 648 and fill the chamber 650 on one side of the membrane of the middle portion 646. Because the middle portion membrane 646 is biased toward the membrane seat 654, the aperture 656 will not permit fluid to flow to the other side of the membrane. When the intraocular pressure reaches an elevated level, the fluid pressure within the chamber 650 will create a force against the membrane 646 and cause the membrane 646 to disengage the membrane seat 654. As the membrane 646 disengages the membrane seat 654, the membrane aperture 656 permits fluid to flow through the membrane 646 into the other side of the chamber 650 and out the outflow apertures 652. The pressure at which the membrane will be deflected from the membrane seat 654 preferably corresponds to acceptable intraocular pressure levels. The large surface area of the membrane 646 will provide for a low tolerance of pressure regulation.
The shunt 630 is preferably implanted following the creation of an incision in the tissue. In some embodiments, the delivery instrument may create the incision for the shunt 630 and insert the shunt 630 into the incision. In yet other embodiments, the shunt 630 can have a sharpened outflow end 640 and create the incision itself as it is advanced through the tissue.
Embodiments Illustrated in
In some embodiments of the illustrated shunts in
Embodiments Illustrated in
Embodiments Illustrated in
Embodiments Illustrated in
In some embodiments, it is desirable to implant a shunt through the fibrous attachment zone, thus connecting the anterior chamber to the uveoscleral outflow pathway, in order to reduce the intraocular pressure in glaucomatous patients. In some embodiments, it is desirable to deliver the shunt with a device that traverses the eye internally (ab interno), through a small incision in the limbus.
The delivery instrument/shunt assembly must be passed between the iris and the cornea to reach the iridocorneal angle. Therefore, the height of the delivery instrument/shunt assembly (dimension 1095 in
The suprachoroidal space between the choroid and the sclera generally forms an angle 1110 of about 55 degrees with the optical axis 1115 of the eye. This angle, in addition to the height requirement described in the preceding paragraph, are features to consider in the geometrical design of the delivery instrument/shunt assembly.
The overall geometry of the system makes it advantageous that the delivery instrument 1130 incorporates a distal curvature 1140, as shown in
The distal curvature 1140 of delivery instrument 1130 may be characterized as a radius of approximately 10 to 30 mm, and preferably about 20 mm. The distal angle of the delivery instrument depicted in
Embodiments Illustrated in
In some embodiments, the flexible shunt has an outer diameter of approximately 0.1 to 2.0 mm diameter, preferably about 0.4 mm. The length of the shunt is approximately 0.5 to 7 mm, preferably about 2 to 4 mm.
The shunt may also incorporate fixation features 2060, such as flexible radial extensions. The extensions may be separate pieces attached to the shunt, or may be formed by slitting the shunt wall, and thermally forming or mechanically deforming the extensions radially outward, as shown in
Embodiments Illustrated in
In some embodiments, during clinical use, the shunt and shaft assembly can be advanced together through the limbus, across the iris, and through the ciliary muscle until the shunt tip is located in the suprachoroidal space. The operator then simultaneously pushes on the stylet 2120 while pulling back on the delivery instrument 2100, such that the shunt tip maintains its location in the suprachoroidal space. The shunt 2110 is released distally from the delivery instrument 2100, and the delivery instrument 2100 is retracted proximally. At this point, the shunt 2110 is still riding on the distal end of the stylet 2120. The next step is to withdraw the stylet 2120, leaving the shunt 2110 in place in the tissue. Finally, the delivery instrument 2100 is withdrawn from the anterior chamber through the incision.
A shunt and delivery instrument assembly, including a flexible stylet, similar to that shown in
Embodiments Illustrated in
Embodiments Illustrated in
Embodiments Illustrated in
Further embodiments of the invention incorporate injection of viscoelastic through the shunt or through the shaft 2250 in order to accomplish posterior dissection of the suprachoroidal tissue, thereby creating a volumetric chamber or reservoir for aqueous humor. In addition or in the alternative, therapeutic agents (e.g., a hyperosmatic agent) can be delivered into the suprachoroidal space through the shunt 2220 or through the shaft 2250.
Embodiments Illustrated in
Embodiments Illustrated in
Embodiments Illustrated in
Embodiments Illustrated in
Embodiments Illustrated in
Embodiments Illustrated in
Embodiments Illustrated in
Embodiments Illustrated in
In some embodiments, the implant comprises one or more openings 2905 communicating with an interior chamber, or lumen, within the implant. Preferably, the edges of the openings are rounded as shown. In addition or in the alternative, the implant can include other exterior surface irregularities (e.g., annular grooves) to anchor the implant, as described above.
In some embodiments the shunt can have a flange 2910 at a proximal portion of the implant. Preferably, the flange has sharp edges and corners as shown. The sharp edges and corners tend to inhibit cell proliferation near the influent end of the implant.
The wire or similar elongated structure 2920 can function as a trocar. Preferably, the wire 2920 is self-trephinating. The radius of the tip of the distal portion 2930 of the wire 2920 can be about 10 to about 500 microns. In some embodiments, the radius of the tip of the distal portion 2930 of the wire 2920 can be about 70 to about 200 microns. The distal portion 2930 of wire 2920 can increase in cross-sectional size towards the proximal direction. In some embodiments, the increase can be in a parabolic manner. In the depicted embodiment, the wire 2920 has a distal portion 2930 having a gradual increase in cross-sectional size in a parabolic manner towards the proximal direction. The wire 2920 can have a rounded distal tip of the distal portion 2930. In other embodiments, the distal portion can be tapered. The wire can be superelastic, flexible, or relatively inflexible with respect to the shunt. The wire can be pre-formed to have a certain shape. The wire can be curved. The wire can have shape memory, or be elastic. In some embodiments, the wire is a pull wire. The wire can be a steerable catheter.
In some embodiments, a pusher 2950 can used in conjunction with the wire 2920 to aid in delivery of the shunt 2900. The pusher 2950 can be used to hold the shunt 2900 in place as the wire 2920 is withdrawn proximally after the shunt 2900 has been delivered to a desired location.
The pusher 2950, trocar 2920 and implant 2900 preferably are sized to fit and move (e.g., slide) within an outer sheath or needle. The needle preferably includes a sharpened distal end to penetrate tissue (e.g., corneal tissue) when accessing the anterior chamber of the eye.
Embodiments Illustrated in
In the embodiment illustrated in
The outflow configuration shown in
The shunt aspects described in connection with
Embodiments Illustrated in
Embodiments Illustrated in
Embodiments Illustrated in
Embodiments Illustrated in
The shunt 4200a illustrated in
Embodiments Illustrated in
Variations
In some embodiments, the shunt can facilitate delivery of a therapeutic agent. The therapeutic agent can be, for example, heparin, TGF-beta, an intraocular pressure-lowering drug, and an anti-proliferative agent. In some embodiments, the therapeutic agent is introduced concurrently with the delivery of the shunt to the eye. The therapeutic agent can be part of the shunt itself. For example, the therapeutic agent can be embedded in the material of the shunt, or coat at least a portion of the shunt. The therapeutic agent may be present on various portions of the shunt. For example, the therapeutic agent may be present on the distal end of the shunt, or the proximal end of the shunt. The shunt can include combination of therapeutic agents. The different therapeutic agents can be separated or combined. One kind of therapeutic agent can be present at the proximal end of the shunt, and a different kind of therapeutic agent can be present at the distal end of the shunt. For example, an anti-proliferative agent may be present at the distal end of the shunt to prevent growth, and a growth-promoting agent may be applied to the proximal end of the shunt to promote growth. In some embodiments, the therapeutic agent is delivered through the implant to the desired location in the eye, such as the uveoscleral outflow pathway. In some embodiments, the therapeutic agent is delivered to the uveoscleral outflow pathway in combination with a therapeutic agent delivered via trans pars plana vitrectomy, thereby delivering a therapeutic agent to both sides of the retina. In some embodiments, the shunt can improve access of topical medication to the posterior uvea. In some embodiments, the shunt is used to delivery a topical medication to treat a chorio-retinal disease.
If desired, more than one shunt of the same or different type may be implanted. For example, the shunts disclosed herein may be used in combination with trabecular bypass shunts, such as those disclosed in U.S. Patent Publication 2004/0050392 (Appendix A), and those described in U.S. Patent Publication 2005/0271704, filed Mar. 18, 2005, the entirety of which is incorporated herein by reference and made a part of this specification and disclosure. Additionally, implantation may be performed in combination with other surgical procedures, such as cataract surgery. All or a portion of the shunt may be coated, e.g. with heparin, preferably in the flow path, to reduce blood thrombosis or tissue restenosis.
If desired, a multiplicity of shunts having different flow capacities and/or lumen sizes may be implanted. For example, a single “large” lumen stent can be implanted first, and subsequent, depending on the pressure response to the first stent, a second can be added with potentially smaller flow capacity in order to “fine tune” the desired IOP. For example, the IOP of a first patient can safely be brought down to approximately 12-18 mm Hg, and once the flow capacity of the first stent is matched with the IOP reduction, a calculation can be made as to what additional outflow is required to achieve target pressures of, for example, approximately 8-12 mmHg. An appropriately sized stent can be added to accomplish the target pressure. Both stents can be proactively added at the same time based on calculated outflow requirements. Alternatively, the stents can be added sequentially as described above based on the measured effect of the first stent.
While certain embodiments of the disclosure have been described, these embodiments have been presented by way of example only, and are not intended to limit the scope of the disclosure. Indeed, the novel methods, systems, and devices described herein may be embodied in a variety of other forms. For example, embodiments of one illustrated or described shunt can be combined with embodiments of another illustrated or described shunt. Moreover, the shunts described above can be utilized for other purposes. For example, the shunts can be used to drain fluid from the anterior chamber to other locations of the eye or outside the eye. Furthermore, various omissions, substitutions and changes in the form of the methods, systems, and devices described herein may be made without departing from the spirit of the disclosure.
This application is a continuation of U.S. patent application Ser. No. 13/964,579, filed Aug. 12, 2013, which is a continuation of U.S. patent application Ser. No. 11/938,238, filed Nov. 9, 2007, now U.S. Pat. No. 8,506,515, which claims priority and the benefit under 35 U.S.C. § 119(e) to Provisional Patent Application Ser. No. 60/857,872, filed Nov. 10, 2006, Ser. No. 60/880,091, filed Jan. 11, 2007, Ser. No. 60/890,610, filed Feb. 19, 2007, and Ser. No. 60/947,942, filed Jul. 3, 2007. Each of these disclosures is hereby incorporated by reference herein in its entirety.
| Number | Name | Date | Kind |
|---|---|---|---|
| 2031754 | Mills | Feb 1936 | A |
| 2127903 | Bowen | Aug 1938 | A |
| 2269963 | Frederick | Jan 1942 | A |
| 3416530 | Ness | Dec 1968 | A |
| 3439675 | Cohen | Apr 1969 | A |
| 3717151 | Collett | Feb 1973 | A |
| 3788327 | Donowitz et al. | Jan 1974 | A |
| 3809093 | Abraham | May 1974 | A |
| 3827700 | Kaller | Aug 1974 | A |
| 3863623 | Trueblood et al. | Feb 1975 | A |
| 3915172 | Krejci et al. | Oct 1975 | A |
| 3948271 | Aklyama | Apr 1976 | A |
| 3948871 | Butterfield et al. | Apr 1976 | A |
| 3976077 | Kerfoot, Jr. | Aug 1976 | A |
| 4030480 | Meyer | Jun 1977 | A |
| 4037604 | Newkirk | Jul 1977 | A |
| 4043346 | Mobley et al. | Aug 1977 | A |
| 4113088 | Binkhorst | Sep 1978 | A |
| 4168697 | Cantekin | Sep 1979 | A |
| 4175563 | Arenberg et al. | Nov 1979 | A |
| 4299227 | Lincoff | Nov 1981 | A |
| 4328803 | Pape | May 1982 | A |
| 4366582 | Faulkner | Jan 1983 | A |
| 4402681 | Haas et al. | Sep 1983 | A |
| 4428746 | Mendez | Jan 1984 | A |
| 4449529 | Burns et al. | May 1984 | A |
| 4449974 | Messingschlager | May 1984 | A |
| 4501274 | Skjaerpe | Feb 1985 | A |
| 4521210 | Wong | Jun 1985 | A |
| 4554918 | White | Nov 1985 | A |
| 4560383 | Leiske | Dec 1985 | A |
| 4578058 | Grandon | Mar 1986 | A |
| 4583224 | Ishii et al. | Apr 1986 | A |
| 4604087 | Joseph | Aug 1986 | A |
| 4632842 | Karwoski et al. | Dec 1986 | A |
| 4634418 | Binder | Jan 1987 | A |
| 4642090 | Ultrata | Feb 1987 | A |
| 4692142 | Dignam et al. | Sep 1987 | A |
| 4718907 | Karwoski et al. | Jan 1988 | A |
| 4722724 | Schocket | Feb 1988 | A |
| 4733665 | Palmaz | Mar 1988 | A |
| 4750901 | Molteno | Jun 1988 | A |
| 4782819 | Adair | Nov 1988 | A |
| 4787885 | Binder | Nov 1988 | A |
| 4800870 | Reid, Jr. | Jan 1989 | A |
| 4800890 | Cramer | Jan 1989 | A |
| 4804382 | Turina et al. | Feb 1989 | A |
| 4820626 | Williams et al. | Apr 1989 | A |
| 4846172 | Berlin | Jul 1989 | A |
| 4846793 | Leonard et al. | Jul 1989 | A |
| 4853224 | Wong | Aug 1989 | A |
| 4863457 | Lee | Sep 1989 | A |
| 4867173 | Leoni | Sep 1989 | A |
| 4870953 | DonMicheal et al. | Oct 1989 | A |
| 4883864 | Scholz | Nov 1989 | A |
| 4886488 | White | Dec 1989 | A |
| 4900300 | Lee | Feb 1990 | A |
| 4905667 | Foerster et al. | Mar 1990 | A |
| 4936825 | Ungerleider | Jun 1990 | A |
| 4946436 | Smith | Aug 1990 | A |
| 4968296 | Ritch et al. | Nov 1990 | A |
| 4986810 | Semrad | Jan 1991 | A |
| 4991602 | Amplatz et al. | Feb 1991 | A |
| 4997652 | Wong | Mar 1991 | A |
| 5005577 | Frenekl | Apr 1991 | A |
| 5041081 | Odrich | Aug 1991 | A |
| 5053040 | Goldsmith, III | Oct 1991 | A |
| 5053044 | Mueller et al. | Oct 1991 | A |
| 5073163 | Lippman | Dec 1991 | A |
| 5092837 | Ritch et al. | Mar 1992 | A |
| 5095887 | Leon et al. | Mar 1992 | A |
| 5116327 | Seder et al. | May 1992 | A |
| 5127901 | Odrich | Jul 1992 | A |
| 5129895 | Vassiliadis et al. | Jul 1992 | A |
| 5139502 | Berg et al. | Aug 1992 | A |
| 5164188 | Wong | Nov 1992 | A |
| 5169386 | Becker et al. | Dec 1992 | A |
| 5171213 | Price, Jr. | Dec 1992 | A |
| 5178604 | Baerveldt et al. | Jan 1993 | A |
| 5180362 | Worst | Jan 1993 | A |
| 5207685 | Cinberg et al. | May 1993 | A |
| 5221255 | Mahurkar et al. | Jun 1993 | A |
| 5246451 | Trescony et al. | Sep 1993 | A |
| 5248231 | Denham et al. | Sep 1993 | A |
| 5284476 | Koch | Feb 1994 | A |
| 5290295 | Querals et al. | Mar 1994 | A |
| 5300020 | L'Esperance, Jr. | Apr 1994 | A |
| 5318513 | Leib et al. | Jun 1994 | A |
| 5324306 | Makower et al. | Jun 1994 | A |
| 5334137 | Freeman | Aug 1994 | A |
| 5338291 | Speckman et al. | Aug 1994 | A |
| 5342370 | Simon et al. | Aug 1994 | A |
| 5346464 | Camras | Sep 1994 | A |
| 5358492 | Feibus | Oct 1994 | A |
| 5360399 | Stegmann | Nov 1994 | A |
| 5370607 | Memmen | Dec 1994 | A |
| 5370641 | O'Donnell, Jr. | Dec 1994 | A |
| 5372577 | Ungerleider | Dec 1994 | A |
| 5397300 | Baerveldt et al. | Mar 1995 | A |
| 5409457 | del Cerro et al. | Apr 1995 | A |
| 5415666 | Gourlay et al. | May 1995 | A |
| 5433701 | Rubinstein | Jul 1995 | A |
| 5443505 | Wong et al. | Aug 1995 | A |
| 5445637 | Bretton | Aug 1995 | A |
| 5454796 | Krupin | Oct 1995 | A |
| 5462558 | Kolesa et al. | Oct 1995 | A |
| 5472440 | Beckman | Dec 1995 | A |
| 5476445 | Baerveldt et al. | Dec 1995 | A |
| 5486165 | Stegmann | Jan 1996 | A |
| 5502052 | DeSantis | Mar 1996 | A |
| 5516522 | Peyman et al. | May 1996 | A |
| 5520631 | Nordquist et al. | May 1996 | A |
| 5547993 | Miki | Aug 1996 | A |
| 5556400 | Tunis | Sep 1996 | A |
| 5557453 | Schalz et al. | Sep 1996 | A |
| 5558629 | Baerveldt et al. | Sep 1996 | A |
| 5558630 | Fisher | Sep 1996 | A |
| 5558637 | Allonen et al. | Sep 1996 | A |
| 5562641 | Flomenblit et al. | Oct 1996 | A |
| RE35390 | Smith | Dec 1996 | E |
| 5601094 | Reiss | Feb 1997 | A |
| 5601549 | Miyagi | Feb 1997 | A |
| 5626558 | Suson | May 1997 | A |
| 5626559 | Solomon | May 1997 | A |
| 5626588 | Sauer et al. | May 1997 | A |
| 5639278 | Dereume et al. | Jun 1997 | A |
| 5643321 | McDevitt | Jul 1997 | A |
| 5651782 | Simon et al. | Jul 1997 | A |
| 5651783 | Reynard | Jul 1997 | A |
| 5652236 | Krauss | Jul 1997 | A |
| 5653724 | Imonti | Aug 1997 | A |
| 5663205 | Ogawa et al. | Sep 1997 | A |
| 5665114 | Weadock et al. | Sep 1997 | A |
| 5669501 | Hissong et al. | Sep 1997 | A |
| 5670161 | Healy et al. | Sep 1997 | A |
| 5676679 | Simon et al. | Oct 1997 | A |
| 5681275 | Ahmed | Oct 1997 | A |
| 5681323 | Arick | Oct 1997 | A |
| 5695479 | Jagpal | Dec 1997 | A |
| 5702414 | Richter et al. | Dec 1997 | A |
| 5702419 | Berry et al. | Dec 1997 | A |
| 5704907 | Nordquist et al. | Jan 1998 | A |
| 5713844 | Peyman | Feb 1998 | A |
| 5723005 | Herrick | Mar 1998 | A |
| 5725493 | Avery et al. | Mar 1998 | A |
| 5725529 | Nicholson et al. | Mar 1998 | A |
| 5725546 | Samson | Mar 1998 | A |
| 5733256 | Costin | Mar 1998 | A |
| 5741292 | Mendius | Apr 1998 | A |
| 5741333 | Frid | Apr 1998 | A |
| 5743868 | Brown et al. | Apr 1998 | A |
| 5752928 | de Roulhac et al. | May 1998 | A |
| 5762625 | Igaki | Jun 1998 | A |
| 5766242 | Wong et al. | Jun 1998 | A |
| 5766243 | Christensen et al. | Jun 1998 | A |
| 5767079 | Glaser et al. | Jun 1998 | A |
| 5785674 | Mateen | Jul 1998 | A |
| 5792099 | DeCamp et al. | Aug 1998 | A |
| 5800376 | Vaskelis | Sep 1998 | A |
| 5807244 | Barot | Sep 1998 | A |
| 5807302 | Wandel | Sep 1998 | A |
| 5810870 | Myers et al. | Sep 1998 | A |
| 5814620 | Robinson et al. | Sep 1998 | A |
| 5817100 | Igaki | Oct 1998 | A |
| 5824071 | Nelson et al. | Oct 1998 | A |
| 5824072 | Wong | Oct 1998 | A |
| 5830139 | Abrue | Nov 1998 | A |
| 5830171 | Wallace | Nov 1998 | A |
| 5833694 | Poncet | Nov 1998 | A |
| 5836939 | Negus et al. | Nov 1998 | A |
| 5840041 | Petter et al. | Nov 1998 | A |
| 5846199 | Hijlkema et al. | Dec 1998 | A |
| 5865831 | Cozean et al. | Feb 1999 | A |
| 5868697 | Richter et al. | Feb 1999 | A |
| 5869468 | Freeman | Feb 1999 | A |
| 5879319 | Pynson et al. | Mar 1999 | A |
| 5882327 | Jacob | Mar 1999 | A |
| 5886822 | Spitzer | Mar 1999 | A |
| 5891084 | Lee | Apr 1999 | A |
| 5893837 | Eagles et al. | Apr 1999 | A |
| 5908449 | Bruchman et al. | Jun 1999 | A |
| 5913852 | Magram | Jun 1999 | A |
| 5925342 | Adorante et al. | Jul 1999 | A |
| 5927585 | Moorman et al. | Jul 1999 | A |
| 5932299 | Katoot | Aug 1999 | A |
| 5941250 | Aramant et al. | Aug 1999 | A |
| 5952378 | Stjerschantz et al. | Sep 1999 | A |
| 5968058 | Richter et al. | Oct 1999 | A |
| 5980928 | Terry | Nov 1999 | A |
| 5981598 | Tatton | Nov 1999 | A |
| 5984913 | Kritzinger et al. | Nov 1999 | A |
| 6004302 | Brierley | Dec 1999 | A |
| 6007510 | Nigam | Dec 1999 | A |
| 6007511 | Prywes | Dec 1999 | A |
| 6030416 | Huo et al. | Feb 2000 | A |
| 6033434 | Borghi | Mar 2000 | A |
| 6036678 | Giungo | Mar 2000 | A |
| 6036682 | Lange et al. | Mar 2000 | A |
| 6045557 | White et al. | Apr 2000 | A |
| 6050970 | Baeverldt | Apr 2000 | A |
| 6050999 | Paraschac et al. | Apr 2000 | A |
| 6059772 | Hsia et al. | May 2000 | A |
| 6059812 | Clerc et al. | May 2000 | A |
| 6060463 | Freeman | May 2000 | A |
| 6063116 | Kelleher | May 2000 | A |
| 6063396 | Kelleher | May 2000 | A |
| 6071286 | Mawad | Jun 2000 | A |
| 6074395 | Trott et al. | Jun 2000 | A |
| 6077299 | Adelberg et al. | Jun 2000 | A |
| 6102045 | Nordquist et al. | Aug 2000 | A |
| 6110912 | Kaufman et al. | Aug 2000 | A |
| 6123668 | Abreu | Sep 2000 | A |
| 6135977 | Drasler et al. | Oct 2000 | A |
| 6142990 | Burk | Nov 2000 | A |
| 6146387 | Trott et al. | Nov 2000 | A |
| 6159458 | Bowman et al. | Dec 2000 | A |
| 6165210 | Lau et al. | Dec 2000 | A |
| 6168575 | Soltanpour | Jan 2001 | B1 |
| 6174305 | Mikus et al. | Jan 2001 | B1 |
| 6177427 | Clark et al. | Jan 2001 | B1 |
| 6184250 | Klimko et al. | Feb 2001 | B1 |
| 6186974 | Allan et al. | Feb 2001 | B1 |
| 6187016 | Hedges et al. | Feb 2001 | B1 |
| 6193656 | Jeffries et al. | Feb 2001 | B1 |
| 6194415 | Wheeler et al. | Feb 2001 | B1 |
| 6197056 | Schachar | Mar 2001 | B1 |
| 6201001 | Wang et al. | Mar 2001 | B1 |
| 6203513 | Yaron et al. | Mar 2001 | B1 |
| 6217895 | Guo et al. | Apr 2001 | B1 |
| 6221078 | Bylsma | Apr 2001 | B1 |
| 6224570 | Le et al. | May 2001 | B1 |
| 6228873 | Brandt et al. | May 2001 | B1 |
| 6231597 | Deem et al. | May 2001 | B1 |
| 6231853 | Hillman et al. | May 2001 | B1 |
| 6241721 | Cozean et al. | Jun 2001 | B1 |
| 6251090 | Avery et al. | Jun 2001 | B1 |
| 6254612 | Hieshima | Jul 2001 | B1 |
| 6261256 | Ahmed | Jul 2001 | B1 |
| 6264668 | Prywes | Jul 2001 | B1 |
| 6266182 | Morita | Jul 2001 | B1 |
| 6268398 | Ghosh et al. | Jul 2001 | B1 |
| 6274138 | Bandman et al. | Aug 2001 | B1 |
| 6287256 | Park et al. | Sep 2001 | B1 |
| 6287313 | Sasso | Sep 2001 | B1 |
| 6299603 | Hecker et al. | Oct 2001 | B1 |
| 6299895 | Hammang et al. | Oct 2001 | B1 |
| 6306114 | Freeman et al. | Oct 2001 | B1 |
| 6331313 | Wong et al. | Dec 2001 | B1 |
| 6342058 | Portney | Jan 2002 | B1 |
| 6348042 | Warren, Jr. | Feb 2002 | B1 |
| 6355033 | Moorman et al. | Mar 2002 | B1 |
| 6358222 | Grundei | Mar 2002 | B1 |
| 6361519 | Knudson et al. | Mar 2002 | B1 |
| 6363938 | Saadat et al. | Apr 2002 | B2 |
| 6375642 | Grieshaber et al. | Apr 2002 | B1 |
| 6378526 | Bowman | Apr 2002 | B1 |
| 6402734 | Weiss | Jun 2002 | B1 |
| 6405732 | Edwards et al. | Jun 2002 | B1 |
| 6413540 | Yaacobi | Jul 2002 | B1 |
| 6416777 | Yaacobi | Jul 2002 | B1 |
| 6428501 | Reynard | Aug 2002 | B1 |
| 6428566 | Holt | Aug 2002 | B1 |
| 6436427 | Hammang et al. | Aug 2002 | B1 |
| 6450937 | Mercereau et al. | Sep 2002 | B1 |
| 6450984 | Lynch et al. | Sep 2002 | B1 |
| 6454787 | Maddalo et al. | Sep 2002 | B1 |
| 6464724 | Lynch et al. | Oct 2002 | B1 |
| 6471666 | Odrich | Oct 2002 | B1 |
| 6494857 | Neuhann | Dec 2002 | B1 |
| 6510600 | Yaron et al. | Jan 2003 | B2 |
| 6517483 | Park et al. | Feb 2003 | B2 |
| 6524275 | Lynch et al. | Feb 2003 | B1 |
| 6530896 | Elliott | Mar 2003 | B1 |
| 6533768 | Hill | Mar 2003 | B1 |
| 6544249 | Yu et al. | Apr 2003 | B1 |
| 6548078 | Guo et al. | Apr 2003 | B2 |
| 6558342 | Yaron et al. | May 2003 | B1 |
| 6561974 | Grieshaber et al. | May 2003 | B1 |
| 6579235 | Abita et al. | Jun 2003 | B1 |
| 6582426 | Moorman et al. | Jun 2003 | B2 |
| 6582453 | Tran et al. | Jun 2003 | B1 |
| 6585680 | Bugge | Jul 2003 | B2 |
| 6585753 | Eder et al. | Jul 2003 | B2 |
| 6589198 | Soltanpour et al. | Jul 2003 | B1 |
| 6589203 | Mitrev | Jul 2003 | B1 |
| 6595945 | Brown | Jul 2003 | B2 |
| 6605053 | Kamm et al. | Aug 2003 | B1 |
| 6607542 | Wild | Aug 2003 | B1 |
| 6613343 | Dillingham et al. | Sep 2003 | B2 |
| 6620154 | Amirkhanian et al. | Sep 2003 | B1 |
| 6626858 | Lynch et al. | Sep 2003 | B2 |
| 6629981 | Bui et al. | Oct 2003 | B2 |
| 6638239 | Bergheim et al. | Oct 2003 | B1 |
| 6666841 | Gharib et al. | Dec 2003 | B2 |
| 6676607 | De Juan, Jr. et al. | Jan 2004 | B2 |
| 6682500 | Soltanpour et al. | Jan 2004 | B2 |
| 6699211 | Savage | Mar 2004 | B2 |
| 6699272 | Slepian et al. | Mar 2004 | B2 |
| 6726664 | Yaron et al. | Apr 2004 | B2 |
| 6726676 | Stegmann et al. | Apr 2004 | B2 |
| D490152 | Myall et al. | May 2004 | S |
| 6736791 | Tu et al. | May 2004 | B1 |
| 6763833 | Khera et al. | Jul 2004 | B1 |
| 6764439 | Schaaf et al. | Jul 2004 | B2 |
| 6767346 | Damasco et al. | Jul 2004 | B2 |
| 6780164 | Bergheim et al. | Aug 2004 | B2 |
| 6780165 | Kadziauskas et al. | Aug 2004 | B2 |
| 6783544 | Lynch et al. | Aug 2004 | B2 |
| 6827699 | Lynch et al. | Dec 2004 | B2 |
| 6827700 | Lynch et al. | Dec 2004 | B2 |
| 6827738 | Willis et al. | Dec 2004 | B2 |
| 6893413 | Martin | May 2005 | B2 |
| 6902577 | Lipshitz et al. | Jun 2005 | B2 |
| 6955656 | Bergheim et al. | Oct 2005 | B2 |
| 6966888 | Cullen et al. | Nov 2005 | B2 |
| 6969384 | De Juan, Jr. et al. | Nov 2005 | B2 |
| 6981958 | Gharib et al. | Jan 2006 | B1 |
| 7033603 | Nelson et al. | Apr 2006 | B2 |
| 7041077 | Shields | May 2006 | B2 |
| 7077821 | Durgin | Jul 2006 | B2 |
| 7077848 | de Juan et al. | Jul 2006 | B1 |
| 7090681 | Weber et al. | Aug 2006 | B2 |
| 7094225 | Tu et al. | Aug 2006 | B2 |
| 7101402 | Phelps et al. | Sep 2006 | B2 |
| 7135009 | Tu et al. | Nov 2006 | B2 |
| 7135016 | Asia et al. | Nov 2006 | B1 |
| 7144616 | Unger et al. | Dec 2006 | B1 |
| 7163543 | Smedley et al. | Jan 2007 | B2 |
| 7186232 | Smedley et al. | Mar 2007 | B1 |
| 7192412 | Zhou et al. | Mar 2007 | B1 |
| 7192484 | Chappa et al. | Mar 2007 | B2 |
| 7217263 | Humayun et al. | May 2007 | B2 |
| 7220238 | Lynch et al. | May 2007 | B2 |
| 7273475 | Tu et al. | Sep 2007 | B2 |
| 7291125 | Coroneo | Nov 2007 | B2 |
| 7294115 | Wilk | Nov 2007 | B1 |
| 7297130 | Bergheim et al. | Nov 2007 | B2 |
| 7331984 | Tu et al. | Feb 2008 | B2 |
| 7344528 | Tu et al. | Mar 2008 | B1 |
| 7431710 | Tu et al. | Oct 2008 | B2 |
| 7458953 | Peyman | Dec 2008 | B2 |
| 7468065 | Weber et al. | Dec 2008 | B2 |
| 7488303 | Haffner et al. | Feb 2009 | B1 |
| 7520876 | Ressemann et al. | Apr 2009 | B2 |
| D592746 | Highley et al. | May 2009 | S |
| RE40722 | Chappa | Jun 2009 | E |
| 7563241 | Tu et al. | Jul 2009 | B2 |
| D606190 | Pruitt et al. | Dec 2009 | S |
| 7662123 | Shields | Feb 2010 | B2 |
| 7678065 | Haffner et al. | Mar 2010 | B2 |
| 7708711 | Tu et al. | May 2010 | B2 |
| 7713228 | Robin | May 2010 | B2 |
| 7758624 | Dorn et al. | Jul 2010 | B2 |
| 7771388 | Olsen et al. | Aug 2010 | B2 |
| 7815592 | Coroneo | Oct 2010 | B2 |
| 7850637 | Lynch et al. | Dec 2010 | B2 |
| 7850638 | Coroneo | Dec 2010 | B2 |
| 7857782 | Tu et al. | Dec 2010 | B2 |
| 7867186 | Haffner et al. | Jan 2011 | B2 |
| 7867205 | Bergheim et al. | Jan 2011 | B2 |
| 7879001 | Haffner et al. | Feb 2011 | B2 |
| 7879079 | Tu et al. | Feb 2011 | B2 |
| 7905904 | Stone et al. | Mar 2011 | B2 |
| 7931660 | Aranyi et al. | Apr 2011 | B2 |
| 7945336 | Sauter-Starace et al. | May 2011 | B2 |
| 7959632 | Fugo | Jun 2011 | B2 |
| 7967772 | McKenzie et al. | Jun 2011 | B2 |
| 7997460 | Pardes et al. | Aug 2011 | B2 |
| 8007459 | Haffner et al. | Aug 2011 | B2 |
| 8062244 | Tu et al. | Nov 2011 | B2 |
| 8075511 | Tu et al. | Dec 2011 | B2 |
| 8118768 | Tu et al. | Feb 2012 | B2 |
| 8142364 | Haffner et al. | Mar 2012 | B2 |
| 8197418 | Lal et al. | Jun 2012 | B2 |
| 8267882 | Euteneuer et al. | Sep 2012 | B2 |
| 8273050 | Bergheim et al. | Sep 2012 | B2 |
| 8333742 | Bergheim et al. | Dec 2012 | B2 |
| 8337445 | Tu et al. | Dec 2012 | B2 |
| 8348877 | Tu et al. | Jan 2013 | B2 |
| 8419673 | Rickard | Apr 2013 | B2 |
| 8506515 | Burns | Aug 2013 | B2 |
| 8540659 | Berlin | Sep 2013 | B2 |
| 8545431 | Rickard | Oct 2013 | B2 |
| 8579846 | Tu et al. | Nov 2013 | B2 |
| 8579848 | Field et al. | Nov 2013 | B2 |
| 8585664 | Dos Santos et al. | Nov 2013 | B2 |
| 8603024 | Bohm et al. | Dec 2013 | B2 |
| 8617094 | Smedley et al. | Dec 2013 | B2 |
| 8656958 | Unger et al. | Feb 2014 | B2 |
| 8679089 | Berlin | Mar 2014 | B2 |
| 8721580 | Rickard et al. | May 2014 | B2 |
| 8753305 | Field et al. | Jun 2014 | B2 |
| 8771220 | Nissan | Jul 2014 | B2 |
| 8801648 | Bergheim et al. | Aug 2014 | B2 |
| 8808219 | Bergheim et al. | Aug 2014 | B2 |
| 8808220 | Coroneo | Aug 2014 | B2 |
| 8808224 | Rickard | Aug 2014 | B2 |
| 8814820 | Bergheim et al. | Aug 2014 | B2 |
| 8840578 | Dos Santos et al. | Sep 2014 | B2 |
| 8852137 | Horvath et al. | Oct 2014 | B2 |
| 8852266 | Brooks et al. | Oct 2014 | B2 |
| 8864701 | Dos Santos et al. | Oct 2014 | B2 |
| 8956320 | Ovchinnikov et al. | Feb 2015 | B2 |
| 8986240 | Dos Santos et al. | Mar 2015 | B2 |
| 8998838 | Yalamanchili | Apr 2015 | B2 |
| 8998983 | Auld | Apr 2015 | B2 |
| 9066782 | Tu et al. | Jun 2015 | B2 |
| 9072588 | Bohm et al. | Jul 2015 | B2 |
| 9125721 | Field | Sep 2015 | B2 |
| 9132034 | Dos Santos | Sep 2015 | B2 |
| 9155653 | Field | Oct 2015 | B2 |
| 9155654 | Tu et al. | Oct 2015 | B2 |
| 9173775 | Haffner et al. | Nov 2015 | B2 |
| 9220632 | Smedley et al. | Dec 2015 | B2 |
| 9226851 | Gunn | Jan 2016 | B2 |
| 9283115 | Lind et al. | Mar 2016 | B2 |
| 9289324 | Johnson et al. | Mar 2016 | B2 |
| 9301875 | Tu et al. | Apr 2016 | B2 |
| 9554940 | Haffner et al. | Jan 2017 | B2 |
| 9561131 | Tu et al. | Feb 2017 | B2 |
| 9572963 | Tu et al. | Feb 2017 | B2 |
| 9585789 | Silvestrini | Mar 2017 | B2 |
| 9592151 | Rangel-Friedman et al. | Mar 2017 | B2 |
| 9597230 | Haffner et al. | Mar 2017 | B2 |
| 9603738 | Haffner et al. | Mar 2017 | B2 |
| 9603741 | Berlin | Mar 2017 | B2 |
| 9636255 | Haffner et al. | May 2017 | B2 |
| 9668915 | Haffner et al. | Jun 2017 | B2 |
| 9833357 | Berlin | Dec 2017 | B2 |
| 9849027 | Highley et al. | Dec 2017 | B2 |
| 9962290 | Burns | May 2018 | B2 |
| 9987472 | Tu et al. | Jun 2018 | B2 |
| 9993368 | Bergheim et al. | Jun 2018 | B2 |
| 10188551 | Rangel-Friedman et al. | Jan 2019 | B2 |
| 10206813 | Haffner et al. | Feb 2019 | B2 |
| 10271989 | Haffner et al. | Apr 2019 | B2 |
| 10406029 | Tu et al. | Sep 2019 | B2 |
| 10485701 | Haffner et al. | Nov 2019 | B2 |
| 10492950 | Lynch et al. | Dec 2019 | B2 |
| 10517759 | Crimaldi et al. | Dec 2019 | B2 |
| 20010000527 | Yaron et al. | Apr 2001 | A1 |
| 20010025150 | de Juan et al. | Sep 2001 | A1 |
| 20010053873 | Schaaf et al. | Dec 2001 | A1 |
| 20020013546 | Grieshaber et al. | Jan 2002 | A1 |
| 20020013572 | Berlin | Jan 2002 | A1 |
| 20020026200 | Savage | Feb 2002 | A1 |
| 20020052640 | Bigus et al. | May 2002 | A1 |
| 20020072673 | Yamamoto et al. | Jun 2002 | A1 |
| 20020099434 | Buscemi et al. | Jul 2002 | A1 |
| 20020111608 | Baerveldt et al. | Aug 2002 | A1 |
| 20020120284 | Schachar et al. | Aug 2002 | A1 |
| 20020120285 | Schachar et al. | Aug 2002 | A1 |
| 20020133168 | Smedley et al. | Sep 2002 | A1 |
| 20020143284 | Tu et al. | Oct 2002 | A1 |
| 20020165522 | Holmen | Nov 2002 | A1 |
| 20020177856 | Richter et al. | Nov 2002 | A1 |
| 20020188308 | Tu et al. | Dec 2002 | A1 |
| 20030014021 | Holmen | Jan 2003 | A1 |
| 20030014092 | Neuhann | Jan 2003 | A1 |
| 20030019833 | Unger et al. | Jan 2003 | A1 |
| 20030055372 | Lynch et al. | Mar 2003 | A1 |
| 20030060752 | Bergheim et al. | Mar 2003 | A1 |
| 20030069637 | Lynch et al. | Apr 2003 | A1 |
| 20030079329 | Yaron et al. | May 2003 | A1 |
| 20030088260 | Smedley et al. | May 2003 | A1 |
| 20030093084 | Nissan et al. | May 2003 | A1 |
| 20030097117 | Buono | May 2003 | A1 |
| 20030097151 | Smedley et al. | May 2003 | A1 |
| 20030105456 | Lin | Jun 2003 | A1 |
| 20030109907 | Shadduck | Jun 2003 | A1 |
| 20030135149 | Cullen et al. | Jul 2003 | A1 |
| 20030139729 | Stegmann et al. | Jul 2003 | A1 |
| 20030181848 | Bergheim et al. | Sep 2003 | A1 |
| 20030187384 | Bergheim et al. | Oct 2003 | A1 |
| 20030187385 | Bergheim et al. | Oct 2003 | A1 |
| 20030195438 | Petillo | Oct 2003 | A1 |
| 20030208163 | Yaron et al. | Nov 2003 | A1 |
| 20030208217 | Dan | Nov 2003 | A1 |
| 20030212383 | Cote et al. | Nov 2003 | A1 |
| 20030229303 | Haffner et al. | Dec 2003 | A1 |
| 20030236483 | Ren | Dec 2003 | A1 |
| 20030236484 | Lynch et al. | Dec 2003 | A1 |
| 20040015140 | Shields | Jan 2004 | A1 |
| 20040024345 | Gharib et al. | Feb 2004 | A1 |
| 20040050392 | Tu et al. | Mar 2004 | A1 |
| 20040088048 | Richter et al. | May 2004 | A1 |
| 20040098122 | Lee et al. | May 2004 | A1 |
| 20040102729 | Haffner et al. | May 2004 | A1 |
| 20040111050 | Smedley et al. | Jun 2004 | A1 |
| 20040127843 | Tu et al. | Jul 2004 | A1 |
| 20040147870 | Burns et al. | Jul 2004 | A1 |
| 20040154946 | Solovay et al. | Aug 2004 | A1 |
| 20040193095 | Shadduck | Sep 2004 | A1 |
| 20040193262 | Shadduck | Sep 2004 | A1 |
| 20040215126 | Ahmed | Oct 2004 | A1 |
| 20040225250 | Yablonski | Nov 2004 | A1 |
| 20040236343 | Taylor et al. | Nov 2004 | A1 |
| 20040243227 | Starksen et al. | Dec 2004 | A1 |
| 20040249404 | Haefliger | Dec 2004 | A1 |
| 20040254517 | Quiroz-Mercado et al. | Dec 2004 | A1 |
| 20040254520 | Porteous et al. | Dec 2004 | A1 |
| 20040254521 | Simon | Dec 2004 | A1 |
| 20040260227 | Lisk, Jr. et al. | Dec 2004 | A1 |
| 20050038334 | Lynch et al. | Feb 2005 | A1 |
| 20050038498 | Dubrow et al. | Feb 2005 | A1 |
| 20050049578 | Tu et al. | Mar 2005 | A1 |
| 20050055075 | Pinchuk et al. | Mar 2005 | A1 |
| 20050096639 | Slatkine et al. | May 2005 | A1 |
| 20050107734 | Coroneo | May 2005 | A1 |
| 20050119737 | Bene et al. | Jun 2005 | A1 |
| 20050125003 | Pinchuk et al. | Jun 2005 | A1 |
| 20050165385 | Simon | Jul 2005 | A1 |
| 20050171562 | Criscuolo et al. | Aug 2005 | A1 |
| 20050192527 | Gharib et al. | Sep 2005 | A1 |
| 20050209549 | Bergheim et al. | Sep 2005 | A1 |
| 20050209672 | George et al. | Sep 2005 | A1 |
| 20050240143 | Dohlman | Oct 2005 | A1 |
| 20050240222 | Shipp | Oct 2005 | A1 |
| 20050250788 | Tu et al. | Nov 2005 | A1 |
| 20050267478 | Corradi et al. | Dec 2005 | A1 |
| 20050271704 | Tu et al. | Dec 2005 | A1 |
| 20050277864 | Haffner et al. | Dec 2005 | A1 |
| 20060032507 | Tu | Feb 2006 | A1 |
| 20060069340 | Simon | Mar 2006 | A1 |
| 20060084907 | Bergheim et al. | Apr 2006 | A1 |
| 20060106370 | Baerveldt et al. | May 2006 | A1 |
| 20060116626 | Smedley et al. | Jun 2006 | A1 |
| 20060155238 | Shields | Jul 2006 | A1 |
| 20060155300 | Stamper et al. | Jul 2006 | A1 |
| 20060173397 | Tu et al. | Aug 2006 | A1 |
| 20060195055 | Bergheim et al. | Aug 2006 | A1 |
| 20060195056 | Bergheim et al. | Aug 2006 | A1 |
| 20060200113 | Haffner et al. | Sep 2006 | A1 |
| 20060210605 | Chang et al. | Sep 2006 | A1 |
| 20060217741 | Ghannoum | Sep 2006 | A1 |
| 20060241580 | Mittelstein et al. | Oct 2006 | A1 |
| 20060241749 | Tu et al. | Oct 2006 | A1 |
| 20070004998 | Rodgers et al. | Jan 2007 | A1 |
| 20070021653 | Hattenbach et al. | Jan 2007 | A1 |
| 20070073275 | Conston et al. | Mar 2007 | A1 |
| 20070073390 | Lee | Mar 2007 | A1 |
| 20070078471 | Schachar et al. | Apr 2007 | A1 |
| 20070088242 | Coroneo | Apr 2007 | A1 |
| 20070093740 | Shetty | Apr 2007 | A1 |
| 20070106199 | Krivoy et al. | May 2007 | A1 |
| 20070106235 | Coroneo | May 2007 | A1 |
| 20070106236 | Coroneo | May 2007 | A1 |
| 20070118065 | Pinchuk et al. | May 2007 | A1 |
| 20070118066 | Pinchuk et al. | May 2007 | A1 |
| 20070123812 | Pinchuk et al. | May 2007 | A1 |
| 20070123919 | Schachar et al. | May 2007 | A1 |
| 20070149915 | Yablonski | Jun 2007 | A1 |
| 20070149927 | Itou et al. | Jun 2007 | A1 |
| 20070154621 | Raad | Jul 2007 | A1 |
| 20070156079 | Brown | Jul 2007 | A1 |
| 20070161981 | Sanders et al. | Jul 2007 | A1 |
| 20070179426 | Selden | Aug 2007 | A1 |
| 20070179471 | Christian et al. | Aug 2007 | A1 |
| 20070191863 | De Juan et al. | Aug 2007 | A1 |
| 20070202186 | Yamamoto et al. | Aug 2007 | A1 |
| 20070207186 | Scanlon et al. | Sep 2007 | A1 |
| 20070212386 | Patravale et al. | Sep 2007 | A1 |
| 20070212387 | Patravale et al. | Sep 2007 | A1 |
| 20070212388 | Patravale et al. | Sep 2007 | A1 |
| 20070212393 | Patravale et al. | Sep 2007 | A1 |
| 20070233037 | Gifford, III et al. | Oct 2007 | A1 |
| 20070276315 | Haffner | Nov 2007 | A1 |
| 20070276316 | Haffner | Nov 2007 | A1 |
| 20070282244 | Tu et al. | Dec 2007 | A1 |
| 20070287958 | McKenzie et al. | Dec 2007 | A1 |
| 20070292470 | Thornton | Dec 2007 | A1 |
| 20070293807 | Lynch et al. | Dec 2007 | A1 |
| 20070293873 | Chang | Dec 2007 | A1 |
| 20080027304 | Pardo et al. | Jan 2008 | A1 |
| 20080033351 | Trogden et al. | Feb 2008 | A1 |
| 20080039931 | Jelle et al. | Feb 2008 | A1 |
| 20080045878 | Bergheim et al. | Feb 2008 | A1 |
| 20080051681 | Schwartz | Feb 2008 | A1 |
| 20080058704 | Hee et al. | Mar 2008 | A1 |
| 20080082078 | Berlin | Apr 2008 | A1 |
| 20080091224 | Griffis, III et al. | Apr 2008 | A1 |
| 20080097214 | Meyers et al. | Apr 2008 | A1 |
| 20080097335 | Trogden et al. | Apr 2008 | A1 |
| 20080108932 | Rodgers | May 2008 | A1 |
| 20080108933 | Yu et al. | May 2008 | A1 |
| 20080109037 | Steiner et al. | May 2008 | A1 |
| 20080114440 | Hlavka et al. | May 2008 | A1 |
| 20080125691 | Yaron et al. | May 2008 | A1 |
| 20080140059 | Schachar et al. | Jun 2008 | A1 |
| 20080147083 | Vold et al. | Jun 2008 | A1 |
| 20080161907 | Chen et al. | Jul 2008 | A1 |
| 20080183289 | Werblin | Jul 2008 | A1 |
| 20080188860 | Vold | Aug 2008 | A1 |
| 20080195027 | Coroneo | Aug 2008 | A1 |
| 20080200860 | Tu et al. | Aug 2008 | A1 |
| 20080200923 | Beckman et al. | Aug 2008 | A1 |
| 20080208176 | Loh | Aug 2008 | A1 |
| 20080210322 | Unger et al. | Sep 2008 | A1 |
| 20080215062 | Bowen et al. | Sep 2008 | A1 |
| 20080221501 | Cote et al. | Sep 2008 | A1 |
| 20080228127 | Burns et al. | Sep 2008 | A1 |
| 20080236669 | Unger et al. | Oct 2008 | A1 |
| 20080243156 | John | Oct 2008 | A1 |
| 20080243243 | Williams et al. | Oct 2008 | A1 |
| 20080255545 | Mansfield et al. | Oct 2008 | A1 |
| 20080269730 | Dotson | Oct 2008 | A1 |
| 20080277007 | Unger et al. | Nov 2008 | A1 |
| 20080281250 | Bergsneider et al. | Nov 2008 | A1 |
| 20080289710 | Unger et al. | Nov 2008 | A1 |
| 20080306429 | Shields et al. | Dec 2008 | A1 |
| 20090043242 | Bene et al. | Feb 2009 | A1 |
| 20090043321 | Conston et al. | Feb 2009 | A1 |
| 20090043365 | Friedland et al. | Feb 2009 | A1 |
| 20090112245 | Haefliger | Apr 2009 | A1 |
| 20090124973 | D'Agostino et al. | May 2009 | A1 |
| 20090132040 | Frion et al. | May 2009 | A1 |
| 20090137983 | Bergheim et al. | May 2009 | A1 |
| 20090137989 | Kataoka | May 2009 | A1 |
| 20090138081 | Bergheim et al. | May 2009 | A1 |
| 20090151422 | Unger et al. | Jun 2009 | A1 |
| 20090182421 | Silvestrini et al. | Jul 2009 | A1 |
| 20090198213 | Tanaka | Aug 2009 | A1 |
| 20090204053 | Nissan et al. | Aug 2009 | A1 |
| 20090227933 | Karageozian | Sep 2009 | A1 |
| 20090227934 | Eutenever et al. | Sep 2009 | A1 |
| 20090264813 | Chang | Oct 2009 | A1 |
| 20090287233 | Huculak | Nov 2009 | A1 |
| 20090326432 | Schmidt et al. | Dec 2009 | A1 |
| 20100004581 | Brigatti et al. | Jan 2010 | A1 |
| 20100010416 | Juan, Jr. et al. | Jan 2010 | A1 |
| 20100010452 | Paques et al. | Jan 2010 | A1 |
| 20100025613 | Tai et al. | Feb 2010 | A1 |
| 20100030150 | Paques et al. | Feb 2010 | A1 |
| 20100042209 | Guarnieri | Feb 2010 | A1 |
| 20100057055 | Camras et al. | Mar 2010 | A1 |
| 20100057093 | Ide et al. | Mar 2010 | A1 |
| 20100076419 | Chew et al. | Mar 2010 | A1 |
| 20100087774 | Haffner et al. | Apr 2010 | A1 |
| 20100106073 | Haffner et al. | Apr 2010 | A1 |
| 20100121248 | Yu et al. | May 2010 | A1 |
| 20100121249 | Yu et al. | May 2010 | A1 |
| 20100121342 | Schieber et al. | May 2010 | A1 |
| 20100137981 | Silvestrini et al. | Jun 2010 | A1 |
| 20100152626 | Schwartz | Jun 2010 | A1 |
| 20100152641 | Yablonski | Jun 2010 | A1 |
| 20100158980 | Kopczynski et al. | Jun 2010 | A1 |
| 20100173866 | Hee et al. | Jul 2010 | A1 |
| 20100175767 | Unger et al. | Jul 2010 | A1 |
| 20100185138 | Yaron et al. | Jul 2010 | A1 |
| 20100185205 | Novakovic et al. | Jul 2010 | A1 |
| 20100191103 | Stamper et al. | Jul 2010 | A1 |
| 20100225061 | Bath | Sep 2010 | A1 |
| 20100234791 | Lynch et al. | Sep 2010 | A1 |
| 20100240987 | Christian et al. | Sep 2010 | A1 |
| 20100241046 | Pinchuk et al. | Sep 2010 | A1 |
| 20100255061 | De Juan, Jr. et al. | Oct 2010 | A1 |
| 20100262174 | Sretavan | Oct 2010 | A1 |
| 20100274258 | Silvestrini et al. | Oct 2010 | A1 |
| 20100274259 | Yaron et al. | Oct 2010 | A1 |
| 20100278898 | Hughes et al. | Nov 2010 | A1 |
| 20100280317 | Silvestrini et al. | Nov 2010 | A1 |
| 20110009874 | Wardle et al. | Jan 2011 | A1 |
| 20110009958 | Wardle et al. | Jan 2011 | A1 |
| 20110022065 | Shipp | Jan 2011 | A1 |
| 20110028883 | Juan, Jr. et al. | Feb 2011 | A1 |
| 20110028884 | Coroneo | Feb 2011 | A1 |
| 20110028983 | Silvestrini et al. | Feb 2011 | A1 |
| 20110046536 | Stegmann et al. | Feb 2011 | A1 |
| 20110046728 | Shareef et al. | Feb 2011 | A1 |
| 20110066098 | Stergiopulos | Mar 2011 | A1 |
| 20110071454 | Dos Santos et al. | Mar 2011 | A1 |
| 20110071456 | Rickard | Mar 2011 | A1 |
| 20110071458 | Rickard | Mar 2011 | A1 |
| 20110071459 | Rickard et al. | Mar 2011 | A1 |
| 20110071505 | Rickard et al. | Mar 2011 | A1 |
| 20110071524 | Keller | Mar 2011 | A1 |
| 20110077626 | Baerveldt et al. | Mar 2011 | A1 |
| 20110082385 | Diaz et al. | Apr 2011 | A1 |
| 20110087151 | Coroneo | Apr 2011 | A1 |
| 20110092878 | Tu et al. | Apr 2011 | A1 |
| 20110092965 | Slatkine et al. | Apr 2011 | A1 |
| 20110098629 | Juan, Jr. et al. | Apr 2011 | A1 |
| 20110098809 | Wardle et al. | Apr 2011 | A1 |
| 20110105987 | Bergheim et al. | May 2011 | A1 |
| 20110112546 | Juan, Jr. et al. | May 2011 | A1 |
| 20110118649 | Stegmann et al. | May 2011 | A1 |
| 20110118835 | Silvestrini et al. | May 2011 | A1 |
| 20110144641 | Dimalanta, Jr. et al. | Jun 2011 | A1 |
| 20110202049 | Jia et al. | Aug 2011 | A1 |
| 20110224597 | Stegmann et al. | Sep 2011 | A1 |
| 20110230877 | Huculak et al. | Sep 2011 | A1 |
| 20110244014 | Williams et al. | Oct 2011 | A1 |
| 20110245753 | Sunalp | Oct 2011 | A1 |
| 20110257623 | Marshall et al. | Oct 2011 | A1 |
| 20110306915 | De Juan, Jr. et al. | Dec 2011 | A1 |
| 20110319793 | Hyhynen | Dec 2011 | A1 |
| 20110319806 | Wardle | Dec 2011 | A1 |
| 20120016286 | Silvestrini et al. | Jan 2012 | A1 |
| 20120022409 | Gertner et al. | Jan 2012 | A1 |
| 20120022424 | Yamamoto et al. | Jan 2012 | A1 |
| 20120022429 | Silvestrini et al. | Jan 2012 | A1 |
| 20120035524 | Silvestrini | Feb 2012 | A1 |
| 20120035525 | Silvestrini | Feb 2012 | A1 |
| 20120065570 | Yeung et al. | Mar 2012 | A1 |
| 20120071809 | Tu et al. | Mar 2012 | A1 |
| 20120071908 | Sorensen et al. | Mar 2012 | A1 |
| 20120078158 | Haffner et al. | Mar 2012 | A1 |
| 20120078281 | Cox et al. | Mar 2012 | A1 |
| 20120078362 | Haffner et al. | Mar 2012 | A1 |
| 20120089072 | Cunningham, Jr. | Apr 2012 | A1 |
| 20120089073 | Cunningham, Jr. | Apr 2012 | A1 |
| 20120109040 | Smedley et al. | May 2012 | A1 |
| 20120123439 | Romoda et al. | May 2012 | A1 |
| 20120123440 | Horvath et al. | May 2012 | A1 |
| 20120165721 | Grabner et al. | Jun 2012 | A1 |
| 20120165722 | Horvath et al. | Jun 2012 | A1 |
| 20120165723 | Horvath et al. | Jun 2012 | A1 |
| 20120165933 | Haffner et al. | Jun 2012 | A1 |
| 20120197175 | Horvath et al. | Aug 2012 | A1 |
| 20120203262 | Connors et al. | Aug 2012 | A1 |
| 20120220917 | Silvestrini et al. | Aug 2012 | A1 |
| 20120232570 | Jenson et al. | Sep 2012 | A1 |
| 20120238994 | Nazzaro et al. | Sep 2012 | A1 |
| 20120259195 | Haffner et al. | Oct 2012 | A1 |
| 20120271272 | Hammack et al. | Oct 2012 | A1 |
| 20120283557 | Berlin | Nov 2012 | A1 |
| 20120289883 | Meng et al. | Nov 2012 | A1 |
| 20120310137 | Silvestrini | Dec 2012 | A1 |
| 20120323159 | Wardle et al. | Dec 2012 | A1 |
| 20130006164 | Yaron et al. | Jan 2013 | A1 |
| 20130006165 | Eutenener et al. | Jan 2013 | A1 |
| 20130018295 | Haffner et al. | Jan 2013 | A1 |
| 20130018296 | Bergheim et al. | Jan 2013 | A1 |
| 20130018412 | Journey et al. | Jan 2013 | A1 |
| 20130079701 | Schieber et al. | Mar 2013 | A1 |
| 20130079759 | Dotson et al. | Mar 2013 | A1 |
| 20130090534 | Burns et al. | Apr 2013 | A1 |
| 20130110125 | Silvestrini et al. | May 2013 | A1 |
| 20130131577 | Bronstein et al. | May 2013 | A1 |
| 20130144202 | Field et al. | Jun 2013 | A1 |
| 20130150770 | Horvath et al. | Jun 2013 | A1 |
| 20130150773 | Nissan et al. | Jun 2013 | A1 |
| 20130150774 | Field et al. | Jun 2013 | A1 |
| 20130150776 | Bohm et al. | Jun 2013 | A1 |
| 20130150777 | Bohm et al. | Jun 2013 | A1 |
| 20130158381 | Rickard | Jun 2013 | A1 |
| 20130165840 | Orge | Jun 2013 | A1 |
| 20130184631 | Pinchuk | Jul 2013 | A1 |
| 20130245532 | Tu et al. | Sep 2013 | A1 |
| 20130253404 | Tu | Sep 2013 | A1 |
| 20130253405 | Tu | Sep 2013 | A1 |
| 20130253528 | Haffner et al. | Sep 2013 | A1 |
| 20130281910 | Tu et al. | Oct 2013 | A1 |
| 20130289467 | Haffner et al. | Oct 2013 | A1 |
| 20140034607 | Meng et al. | Feb 2014 | A1 |
| 20140052046 | Peartree et al. | Feb 2014 | A1 |
| 20140081194 | Burns et al. | Mar 2014 | A1 |
| 20140135916 | Clauson et al. | May 2014 | A1 |
| 20140155803 | Silvestrini | Jun 2014 | A1 |
| 20140276332 | Crimaldi et al. | Sep 2014 | A1 |
| 20150065940 | Rangel-Friedman et al. | Mar 2015 | A1 |
| 20150374546 | Hill | Dec 2015 | A1 |
| 20160038338 | Rangel-Friedman et al. | Feb 2016 | A1 |
| 20160151204 | Haffner et al. | Jun 2016 | A1 |
| 20180021170 | Haffner et al. | Jan 2018 | A1 |
| 20180177633 | Haffner et al. | Jun 2018 | A1 |
| 20200155349 | Haffner et al. | May 2020 | A1 |
| 20200179171 | Crimaldi et al. | Jun 2020 | A1 |
| Number | Date | Country |
|---|---|---|
| 200072059 | Jul 2001 | AU |
| 2004264913 | Dec 2011 | AU |
| 2273331 | Jun 1998 | CA |
| 2244646 | Feb 1999 | CA |
| 2311244 | Jun 1999 | CA |
| 2643357 | Nov 1999 | CA |
| 92111244 | Jul 1993 | CH |
| 19840047 | Mar 2000 | DE |
| 10042310 | Mar 2002 | DE |
| 10127666 | Jan 2003 | DE |
| 0436232 | Jul 1991 | EP |
| 0550791 | Jul 1993 | EP |
| 0858788 | Aug 1998 | EP |
| 0881055 | Dec 1998 | EP |
| 0898947 | Mar 1999 | EP |
| 1114627 | Jul 2001 | EP |
| 1534363 | Jun 2005 | EP |
| 2088976 | Aug 2009 | EP |
| 2260803 | Dec 2010 | EP |
| 2351589 | Aug 2011 | EP |
| 2982354 | Feb 2016 | EP |
| 2985012 | Feb 2016 | EP |
| 2553658 | Apr 1985 | FR |
| 2710269 | Mar 1995 | FR |
| 2721499 | Dec 1995 | FR |
| 2757068 | Jun 1998 | FR |
| 2296663 | Jul 1996 | GB |
| 11-123205 | May 1999 | JP |
| 2001-504732 | Apr 2001 | JP |
| 2003-520077 | Jul 2003 | JP |
| 2004-500220 | Jan 2004 | JP |
| 2005-512607 | May 2005 | JP |
| 2005-533619 | Nov 2005 | JP |
| 2012-198134 | Sep 2012 | JP |
| 2013-208434 | Oct 2013 | JP |
| 5328788 | Oct 2013 | JP |
| 2014-193366 | Oct 2014 | JP |
| 2014-240022 | Dec 2014 | JP |
| 2022539 | Nov 1994 | RU |
| 2143250 | Dec 1999 | RU |
| 2160573 | Dec 2000 | RU |
| WO 8900869 | Feb 1989 | WO |
| WO 9108784 | Jun 1991 | WO |
| WO 9118568 | Dec 1991 | WO |
| WO 9208406 | May 1992 | WO |
| WO 9219294 | Nov 1992 | WO |
| WO 9402081 | Feb 1994 | WO |
| WO 9413234 | Jun 1994 | WO |
| WO 9421205 | Sep 1994 | WO |
| WO 9508310 | Mar 1995 | WO |
| WO 9620742 | Jul 1996 | WO |
| WO 9823237 | Jun 1998 | WO |
| WO 1998030181 | Jul 1998 | WO |
| WO 9835639 | Aug 1998 | WO |
| WO 9837831 | Sep 1998 | WO |
| WO 9926567 | Jun 1999 | WO |
| WO 9930641 | Jun 1999 | WO |
| WO 9930644 | Jun 1999 | WO |
| WO 9938470 | Aug 1999 | WO |
| WO 9938470 | Aug 1999 | WO |
| WO 0013627 | Mar 2000 | WO |
| WO 0064389 | Nov 2000 | WO |
| WO 0064390 | Nov 2000 | WO |
| WO 0064391 | Nov 2000 | WO |
| WO 0064393 | Nov 2000 | WO |
| WO 0067687 | Nov 2000 | WO |
| WO 0072788 | Dec 2000 | WO |
| WO 0150943 | Jul 2001 | WO |
| WO 0168016 | Sep 2001 | WO |
| WO 0178631 | Oct 2001 | WO |
| WO 0178656 | Oct 2001 | WO |
| WO 0185065 | Nov 2001 | WO |
| WO 0194784 | Dec 2001 | WO |
| WO 0197727 | Dec 2001 | WO |
| WO 0236052 | May 2002 | WO |
| WO 02074052 | Sep 2002 | WO |
| WO 02102274 | Dec 2002 | WO |
| WO 03015659 | Feb 2003 | WO |
| WO 03041622 | May 2003 | WO |
| WO 03045290 | Jun 2003 | WO |
| WO 03073968 | Sep 2003 | WO |
| WO 04008945 | Jan 2004 | WO |
| WO 2004093761 | Nov 2004 | WO |
| WO 05046782 | May 2005 | WO |
| WO 2005107664 | Nov 2005 | WO |
| WO 2005107845 | Nov 2005 | WO |
| WO 05117780 | Dec 2005 | WO |
| WO 07084582 | Jul 2007 | WO |
| WO 07087061 | Aug 2007 | WO |
| WO 2008061043 | May 2008 | WO |
| WO 2008083118 | Jul 2008 | WO |
| WO 2009012406 | Jan 2009 | WO |
| WO 2009126569 | Oct 2009 | WO |
| WO 2009151543 | Dec 2009 | WO |
| WO 2010093945 | Aug 2010 | WO |
| WO 2010135369 | Nov 2010 | WO |
| WO 2011020633 | Feb 2011 | WO |
| WO 13148275 | Oct 2013 | WO |
| WO 14151070 | Sep 2014 | WO |
| Entry |
|---|
| Bahler, Cindy K., BS, Gregrory T. Smedley, PhD, Jianbo Zhou, PhD, Douglas H. Johnson, MD., Trabecular Bypass Stents Decrease Intraocular Pressure in Cultured Human Anterior Segments, American Journal of Ophthalmology, Dec. 2004, vol. 138, pp. 988-994. |
| Chu, Jennifer, “Detecting the Danger Signs of Glaucoma”, Technology Review Published by MIT, Aug. 15, 2007, 2 pp., http://www.technologyreview.com/printer_friendly_article.aspx?id=19257. |
| Constad, William H., et al., Use of an Angiotensin Converting Enzyme Inhibitor in Ocular Hypertension and Primary Open-Angle Glaucoma, 103 AM J Opthalmol 674 (1988). |
| Coote, “Glaucoma Hollow Fiber Filters—A New Glaucoma Seton. Preliminary Results,” J. Glaucoma, vol. 8, No. 1, Supplement (1999), p. S4 (1 page). |
| De Juan et al., “Refinements in microinstrumentation for vitrous surgery,” Am. J. Ophthalmol. 109:218-20 (1990). |
| Dorland's Illustrated Medical Dictionary, 28th Edition, Philadelphia: W.B. Saunders Company, 1994, p. 167. |
| Ellis, R., “Reduction of Intraocular Pressure Using Plastics in Surgery,” American Journal of Ophthalmology, vol. 50, pp. 733-743 (1960). |
| Emi, Kazayuki, et al., Hydrostatic Pressure of the Suprachoroidal Space, Investigative Ophthalmology & Visual Science, vol. 30, No. 2, Feb. 1989 (pp. 233-239). |
| Fletcher, Daniel A., Ph.D., Daniel V. Palanker, Ph.D., Philip Hule, M.D., Jason Miller, MS, Michael F. Marmor, M.D. and Mark S. Blumenkranz, M.D.; Intravascular Drug Delivery With a Pulsed Liquid Microjet; (Reprinted) Arch Ophthalmology; vol. 120, Sep. 2002, pp. 1206-1208. |
| Grant, W.M., MD, Further Studies on Facility of Flow Through the Trabecular Meshwork, AMA Archives of Ophthalmology, Oct. 1958, vol. 60, pp. 523-533. |
| Grierson, I., R.C. Howes, and Q. Wang, Age-related Changes in the Canal of Schlemm, Exp. Eye Res., 1984, vol. 39, pp. 505-512. |
| Hill, R.A., Q. Ren, D.C. Nguyen, L.H. Liaw, & M.W. Berns, Free-electron Laser (FEL) Ablation of Ocular Tissues, Lasers Med Sci 1998, vol. 13, pp. 219-226. |
| Hill, Richard A., MD, George Baerveldt, MD, Serdar A. Ozler, MD, Michael Pickford, BA, Glen A. Profeta, BS, & Michael W. Berns, PhD, Laser Ablation (LTA), Lasers in Trabecular Surgery and Medicine, 1991, vol. 11, pp. 341-346. |
| Hoeh et al., Early Postoperative Safety and Surgical Outcomes After Implantation of a Suprachoroidal Micro-Stent for the Treatment of Open-Angle Glaucoma Concomitant with Cataract Surgery, 39 J. Cataract Refract. Surg. 431 (2013). |
| Hoerauf, Hans, Christopher Wirbelauer, Christian Scholz, Ralf Engelhardt, Peter Koch, Horst Laqua, and Reginald Birngruber, Slit-lamp-adapted optical coherence tomography of the anterior segment, Graefe's Arch Clin Exp Ophthalmol, 2000, vol. 238, pp. 8-18. |
| Hoskins, et al., “Aqueous Humor Outflow”, Becker-Shaffer's Diagnosis and Therapy of the Glaucomas, 6th Edition, Chapter 4, pp. 41-66, 1989. |
| Hoskins, H. Dunbar, et al., Diagnosis and Therapy of the Glaucomas, Chapter 4: Aqueous Humor Outflow, 61 edition, pp. 41-66 (1989) (28 pages). |
| Jacobi, Phillip C., MD, Thomas S. Dietlein, MD and Gunter K. Krieglstein, MD, Microendoscopic Trabecular Surgery in Glaucoma Management, Ophthalmology, 1999 vol. 106, No. 3, pp. 538-544. |
| Jacobi, Phillip C., MD, Thomas S. Dietlein, MD and Gunter K. Krieglstein, MD, Bimanual Trabecular Aspiration in Pseudoexfoliation Glaucoma, Ophthalmology, 1998, vol. 105, No. 5, May 1998, pp. 886-894. |
| Jacobi, Phillip C., MD, Thomas S. Dietlein, MD and Gunter K. Krieglstein, MD, Goniocurettage for Removing Trabecular Meshwork: Clinical Results of a new Surgical Technique in Advanced Chronic Open-Angle Glaucoma, American Journal of Ophthalmology, May 1999, pp. 505-510. |
| Jocson, Vincente, L., M.D.; Air Trabeculotomy, American Journal of Ophthalmolgy: vol. 79, No. 1, Jan.-Jun. 1975; pp. 107-111. |
| Johnson, et al., Schlemm's Canal Becomes Smaller After Successful Filtration Surgery, (reprinted) ARCM Ophthalmol/vol. 118, Sep. 2000 (www.archophthalmol.com) p. 1251-1256. |
| Johnstone, M.A., R. Stegmann, and B.A. Smit, American Glaucoma Society, 12th Annual Meeting, Cylindrical Tubular Structures Spanning from Trabecular Meshwork Across SC, Laboratory Studies with SEM, TEM and Tracers Correlated with Clinical Findings, Abstract No. 18., p. 39, 2002. |
| Jordan et al., Cyclodialysis ab interno as a surgical approach to intractable glaucoma, Graefe's Arch Clin Exp Opthalmol (2007) 245, pp. 1071-1076. |
| Jordon, et al., “A Novel Approach to Suprachoroidal Drainage for the Surgical Treatment of Intractable Glaucoma,” J Glaucoma 15(3): 200-205 (2006). |
| Katuri, Kalyan C., Asrani, Sanjay and Ramasubramanian, Melur K., “Intraocular Pressure Monitoring Sensors”, IEEE Sensors Journal, vol. 8, No. 1, Jan. 2008, 8 pp. |
| Katz, L. Jay, MD, A Call for Innovative Operations for Glaucoma, Arch Ophthalmology, Mar. 2000, vol. 118, pp. 412-413. |
| Kimura, T., et al.; The Efficacy of Isopropyl Unoppostone in the Concomitant Application of B Blocker, Dipivefrin and Pilocarpine; Glaucoma Clinical Pharmacology II, Abstract B56, IVOS 1998 vol. 39, (cover page and p. No. S258). |
| Klemm, A. Balazs, J. Draeger, R. Wiezorrek, Experimental use of space-retaining substances with extended duration: functional and morphological results, Graefe's Arch Clin Exp Ophthalmol (1995) 233:592-597. |
| Krejci, “Cyclodialysis with Hydroxyethyl Methacrylate Capillary Strip (HCS),” Opthalmologica, vol. 164 (1972), pp. 113-121 (9 pages). |
| Llobet, et al., Understanding Trabecular Meshwork Physiology: A Key to the Control of Intraocular Pressure?, News Physiol Sci vol. 18, pp. 205-209 (2003). |
| Matsumoto, Yasuhiro and Douglas H. Johnson, Trabecular Meshwork Phagocytosis in Glaucomatous Eyes, Ophthalmologica 1977, vol. 211, pp. 147-152. |
| Moses, Robert A., et al., “Blood Reflux in Schlemm's Canal”, Arch Ophthamol., vol. 97, Jul 1979, pp. 1307-1310. |
| Nickells, Robert W., Apoptosis of Retinal Ganglion Cells in Glaucoma: An Update of the Molecular Pathways Involved in Cell Death, Survey of Ophthalmology, vol. 43, Supplement 1, Jun. 1999, pp. S-151 through S-161. |
| Oatts et al., “In vitro an in vivo comparison of two suprachoroidal shunts,” Invest. Opthalmol. Vis. Sci. 54:5416-23 (2013). |
| Ocular Swan Autoclavable Gonioprism from at least as early as Jun. 29, 2007 in 3 pages, downloaded from http://ocularinc.com. |
| Olsen, et al., “Cannulation of the Suprachoroidal Space: A Novel Drug Delivary Methodology to the Posterior Segment”, American Journal of Ophthalmology, Nov. 2006, pp. 777-787.e2 (13 pages). |
| Ozdamar, et al., “Suprachoroidal Seton Implantation in Refractory Glaucoma: A novel Surgical Technique”, Journal of Glaucoma 12:354-359, 2003. |
| Pinnas, G., et al., “Cyclodialysis With Teflon Tube Implants, ”American Journal of Ophthalmology, vol. 68, No. 5 pp. 879-883 (Nov. 1969). |
| Portney, G., M.D., “Silicone Elastomer Implantation Cyclodialysis: A Negative Report,” Arch. Opthalmol., vol. 89, pp. 10-12 (Jan. 1973). |
| Putney, Luanna K., Cecile Rose T. Vibat, and Martha E. O'Donnell, Intracellular C1 Regulates Na—K—C1 Cotransport Activity in Human Trabecular Meshwork Cells, 1999 American Physiological Society, Sep. 1999, pp. C373 through C383. |
| Qu, I., et al., Isolation and characterization of noncytopathic pestivirus mutants reveals a role for nonstructural protein NS4B in viral cytopathogenicity. Nov. 2001 Journal of Virology. vol. 75, No. 22, 10651-62, see Fig. 1 and p. 10654. |
| Radhakrishnan, Sumita, Andrew M. Rollins, Jonathan E. Roth, S. Yazddanfar, Volker Westphal, David Bardenstein, and Joseph Izatt, Real-Time Optical Coherence Tomography of the Anterior Segment at 1310 nm, Arch Ophthalmology, Aug. 2001, vol. 119, pp. 1179-1185. |
| Ritch, et al., “Uveoscleral Outflow,” The Glaucomas, 2nd Edition, Chapter 15, pp. 337-343, 1996. |
| Rohen, Johannes W., Grune & Stratton, Harcourt Brace Jovanovich Publishers, edited by J.E. Cairns, Glaucoma, vol. 1, Chapter 14, Anatomy of the Aqueous Outflow Channels, 1986 pp. 277-296. |
| Rosenberg, et al., “Implants in Glaucoma Surgery”, The Glaucomas 1996, Chapter 88, pp. 1783-1807 (27 pages). |
| Rowan, MD, Combined Cyclodialysis and Cataract Surgery, Ophthalmic Surgery and Lasers, Dec. 1998, vol. 29, No. 12, pp. 962-968 (9 pages). |
| Schwartz, Arthur L., MD, & Douglas R. Anderson, MD, Trabecular Surgery, Arch Ophthalmol, vol. 92, Aug. 1974, pp. 134-138. |
| Sherman, Steven H., et al., “The Fate of Anterior Chamber Fluorescein in the Monkey Eye 1. The Anterior Chamber Outflow Pathways”, Exp. Eye Res. vol. 27, pp. 159-173 (1978) (15 pages). |
| Shields, M. Bruce, MD, A Study Guide for Glaucoma: Aqueous Humor Dynamics, Copyright 1982, pp. 6-43. |
| Shields, M. Bruce, Aqueous Humor Dynamics, Textbook of Glaucoma, Fourth Ed., Williams & Wilkins Publishers, 1998, Ch. 2, pp. 5-31. |
| Spiegel, Detlev, 7 chirurgische Glaukomtherapie, (English translation enclosed) pp. 79-88 Spiegel, D., “Surgical Glaucoma Therapy” in Benefits and Risks of Ophthalmological Therapy (Kampik & Grehn, Eds.) Ch. 7 (Germany 1998). |
| Spiegel, Detliev, MD, Karin Kobuch, MD, Richard A. Hill, MD, Ronald L. Gross, MD, Schlemm's Canal Implant: A New Method to Lower Intraocular Pressure in Patients With POAG?, Opthalmic Surgery and Lasers, Jun. 1999, vol. 30, No. 6, pp. 492-494. |
| Strange, Kevin (edited by), Cellular and Molecular Physiology of Cell Volume Regulation, Library of Congress Cataloging in-Publication Data, CRC Press, Inc., 1994 pp. 312-321. |
| Tatton, W.G., Apoptotic Mechanisms in Neurodegeneration: Possible Relevance to Glaucoma, European Journal of Ophthalmology, Jan.-Mar. 1999, vol. 9, Supplement 1, pp. S22 through S29. |
| Tatton, William, Ruth M.E. Chalmers-Redman, Ajay Sud, Steven M. Podos, and Thomas Mittag, Maintaining Mitochondrial Membrane Impermeability: An Opportunity for New Therapy in Glaucoma, Survey of Ophthalmology, vol. 45, Supplement 3, May 2001, pp. S277 through S283. |
| Timmermans, et al., Possible Subdivion of Postsynapic Adrenoceptors Mediating Pressor Responses in the Pithed Rat; Nauyn-Schmeideberg's Arch. Pharmacol., 310, pp. 189-193 (1979). |
| Tsontcho Ianchulev, Chapter 21: The CyPass Suprachoroidal Micro-Stent, in J.R. Samples &I.I.K. Ahmed (eds.), Surgical Innovations in Glaucoma 229 (Springer Science+Business Media 2014). |
| Troncoso, M.D., Cyclodialysis with Insertion of a Metal Implant in the Treatment of Glaucoma, Read before the Section on Ophthalmology at the Ninetieth Annual Session of the American Medical Association, St. Louis, May 17, 1939, Archives of Ophthalmology, pp. 270-300, downloaded from www.archophthalmol.com on Aug. 5, 2010. |
| Troncoso, Manuel U., Use of tantalum implants for inducing a permanent hypotony in rabbits' eyes, American Journal of Ophthalmology, vol. 32, No. 4, Apr. 1949, pp. 499-508 (11 pages). |
| Wagner, Justin A., Edwards, Aurélie, and Schuman, Joel S., Characterization of Uveoscleral Outflow in Enucleated Porcine Eyes Perfused Under Constant Pressure, Invest Ophthalmol Vis Sci. Sep. 2004; 45(9): 3203-3206 (9 pages). |
| Welsh, N. H., et al., “The ‘deroofing’ of Schlemm's canal in patients with open-angle glaucoma through placement of a collagen drainage device”, Ophthalmic Surg. Lasers, vol. 29, No. 3, Mar. 1998,pp. 216-226 (abstract only). |
| Zhou, Jianbo, PhD, Gregory T. Smedley, PhD., A Trabecular Bypass Flow Hypothesis, Feb. 2005, vol. 14 No. 1, pp. 74-83. |
| Bae, et al., “In vitro experiment of the pressure regulating valve for a glaucoma implant”, Journal of Micromechanics and Microengineering 13.5, 13:613-619, No. 5, Sep. 2003. |
| Bartolomei, et al., “Seton implantation to divert aqueous humor”, Journal of Glaucoma, 13:348-349, No. 4, Aug. 2004. |
| Bucciarelli, Patrice D., Working Model is Next Step in Team's Long Journey to Commercial Product, Healthfirst, Business First of Louisville, louisville.bizjournals.com, Feb. 27, 2004. |
| Chen, et al., “Trabeculetomy combined with implantation of sil-icon rubber slice for intractable glaucoma”, Eye Science, 18:95-98, vol. 2, Jun. 2002. |
| Chen, P.-J., Rodger, D.C., Meng, E., Humayun, M.S., Tai, Y.-C., “Implantable Unpowered Parylene MEMS Intraocular Pressure Sensor”, Microtechnologies in Medicine and Biology, 2006 International Conference on Publication Date: May 9-12, 2006, 5pp., downloaded from http://ieeezxplore.ieee.org/xpl/freeabs_all.jsp?arnumber=4281361. |
| Duane's Ophthalmology on CD-ROM, 2006 Edition, Chapter 56—Medical Therapy of Glaucoma by Marc Weitzman and Joseph Caprioli. |
| Gal, “A novel glaucoma drainage valve”, ProQuest Dissertations Publishing, 131 pages, 1999. |
| Johnson, Douglas H., M.D., et al.: Basic Sciences in Clinical Glaucomal How Does Nonpenetrating Glaucoma Surgery Work? Aqueous Outflow Resistance and Glaucoma Surgery; Journal of Glaucoma; 2001, vol. 10, No. 1, pp. 55-67. |
| Karlen, M. E., et al., “Deep sclerectomy with collagen implant: medium term results”, Br. J. Ophthalmol. vol. 83, No. 1, Jan. 1999, pp. 6-11 (abstract only). |
| Kim et al., Controlled Drug Release from an Ocular Implant: An Evaluation Using Dynamic Three-Dimensional Magnetic Resonance Imaging. Invest Ophthalmol Vis Sci. 2004;45:2722-2731. |
| Lim, “Development of a new glaucoma drainage device”, ProQuest Dissertations Publishing, 147 pages, 2001. |
| Ning, “Optimum Design of a New Aqueous Humor Drainage Implant for Glaucoma and the Animal”, ProQuest Dissertations Publishing, 2004. |
| Pajic, Bojan et al., “A novel technique of ab interno glaucoma surgery: follow-up results after 24 months”, Graefe's Arch Clin Exp Ophthalmol, Jul. 2005, (2006) 244:22-27. |
| Pederson, Jonathan et al., “Uveoscleral Aqueous Outflow in the Rhesus Monkey: Importance of Uveal Reabsorption,” Invest. Ophthalmol, Visual Sci. Nov. 1977, Uveal Reabsorption of Aqueous Humor, vol. 16, No. 11, pp. 1008-1017. |
| Refojo, “Current status of biomaterials in ophthalmology”, Survey of ophthalmology, 26:257-265, No. 5, 1982. |
| Rizq et al., Intraocular Pressure Measurement at the Choroid Surface: A Feasibility Study with Implications for Implantable Microsystems, Br J Ophthalmol 2001; 85:868-871, Jul. 2001. |
| Scott, et al., “Use of glaucoma drainage devices in the management of glaucoma associated with aniridia”, American Journal of Ophthalmology, 135:155-159, No. 2, Feb. 1, 2003. |
| Tham, et al., “Incisional surgery for angle closure glaucoma”, Seminars in Ophthalmology, 17:92-99, No. 2, Jun. 2002. |
| Tsontcho Ianchulev, Chapter 3: Suprachoroidal Space as a Therapeutic Target, in J.R. Samples & I.I.K. Ahmed (eds.), Surgical Innovations in Glaucoma 33 (Springer Science + Business Media 2014). |
| Van Der Veen, G., et al., “The Gonioseton, A Surgical Treatment for Chronic Glaucoma,” Documenta Ophthalmologica, 1990 (75) pp. 365-375. |
| Walter, et al., Development of a Completely Encapsulated Intraocular Pressure Sensor, Ophthalmic Research Nov.-Dec. 2000; 32:278-284. |
| Webster's Third New International Dictionary of the English Language (Unabridged), definitions of “deploy” and “deployment”, p. 605 (2002) (4 pages). |
| Yablonski, “Internal tube shunt from anterior chamber to suprachoroidal space: A novel glaucoma surgery”, IOVS, vol. 46, No. Suppl., p. 1223, 2005. |
| Yablonski, “Trabeculectomy with internal Tube Shunt—A novel Glaucoma surgery”, Journal of Glaucoma, vol. 14, No. 2:91-97, 2005. |
| Number | Date | Country | |
|---|---|---|---|
| 20180325732 A1 | Nov 2018 | US |
| Number | Date | Country | |
|---|---|---|---|
| 60947942 | Jul 2007 | US | |
| 60890610 | Feb 2007 | US | |
| 60880091 | Jan 2007 | US | |
| 60857872 | Nov 2006 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 13964579 | Aug 2013 | US |
| Child | 15971553 | US | |
| Parent | 11938238 | Nov 2007 | US |
| Child | 13964579 | US |
