Claims
- 1. A valve comprising:a valve body defining an aperture, a valve stem having a dispensing passage, the valve stem adapted to slidingly engage a seal, and, the seal constructed from one or more rubbers impregnated with one or more fluorine-containing polymers, wherein the valve is suitable for dispensing a drug formulation comprising one or more medicaments and one or more liquid propellants, and, wherein the medicament is a member selected from the group consisting of salbutamol, beclomethasone dipropionate, terbutaline, salmeterol, fluticasone, formoterol, ipratroprium, budesonide; salts, esters, and solvates thereof; and, combinations thereof.
- 2. The valve of claim 1, wherein the seal comprises up to 20% by weight polytetrafluoroethane.
- 3. The valve of claim 1, wherein the fluorine-containing polymer is selected from the group consisting of polytetrafluoroethane, ethylenetetrafluoroethylene, perfluoroalkoxyalkane, fluorinated ethylene propylene, vinyldienefluoride, chlorinated ethylene tetrafluoroethylene and combinations thereof.
- 4. The valve of claim 3 wherein the fluorine-containing polymer is polytetrafluoroethane.
- 5. The valve of claim 1, wherein the medicament is fluticasone propionate and the propellant is 1,1,1,2-tetrafluoroethane, and wherein the medicament is suspended in the liquid propellant.
- 6. The valve of claim 1, wherein the medicament is salmeterol xinafoate and the propellant is 1,1,1,2-tetrafluoroethane, and wherein the medicament is suspended in the liquid propellant.
- 7. The valve of claim 1, wherein the medicament is salbutamol sulphate and the propellant is 1,1,1,2-tetrafluoroethane, and wherein the medicament is suspended in the liquid propellant.
- 8. The valve of claim 1, wherein the medicament is a combination of fluticasone propionate and salmeterol xinafoate, and wherein the medicament is suspended in the liquid propellant.
- 9. The value of claim 1, wherein seal comprises 5-10 wt. % of the one or more fluorine-containing polymers.
- 10. The valve of claim 9, wherein the one or more rubbers comprises a nitrile-containing rubber.
- 11. The valve of claim 10, wherein the nitrile-containing rubber is peroxide cured.
- 12. An aerosol metering device comprising:a valve body defining an aperture, a valve stem having a dispensing passage, the valve stem adapted to slidingly engage a seal constructed from one or more rubbers impregnated with one or more fluorine-containing polymers, a metering chamber, and a container, wherein the device is suitable for dispensing a drug formulation comprising one or more medicaments and one or more liquid propellants, and, wherein the medicament is a member selected from the group consisting of salbutamol, beclomethasone dipropionate, terbutaline, salmeterol, fluticasone, formoterol, ipratroprium, budesonide; salts, esters, and solvates thereof; and, combinations thereof.
- 13. The aerosol metering device of claim 12, wherein the device is adapted to deliver the medicament suspended in the aerosol which is selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane, and combinations thereof.
- 14. The aerosol metering device of claim 13, wherein the medicament is a member selected from the group consisting of salbutamol sulphate, salmeterol xinafoate, fluticasone propionate and combinations thereof.
- 15. The aerosol metering device of claim 12, wherein the medicament is selected from the group consisting of a respiratory disorder medicament, an analgesic, an anginal preparation, an antiallergic, an antiinfective, an antihistamine, an anti-inflammatory, an antitussive, a bronchodilator, a diuretic, an anticholinergic, a hormone, a xanthine, a therapeutic protein, a therapeutic peptide, and combinations thereof.
- 16. A valve seal comprising:one or more nitrile-containing rubbers impregnated with one or more fluorine-containing polymers.
- 17. The valve seal of claim 15, wherein seal comprises 5-10 wt. % of one or more fluorine-containing polymers.
- 18. The valve seal of claim 16, wherein the fluorine-containing polymer is selected from the group consisting of polytetrafluoroethane, ethylenetetrafluoroethylene, perfluoroalkoxyalkane, fluorinated ethylene propylene, vinyldienefluoride, chlorinated ethylene tetrafluoroethylene and combinations thereof.
- 19. The valve seal of claim 16, wherein the nitrile-containing rubber is peroxide cured.
- 20. A valve seal made, in any suitable order, by the steps of:providing one or more nitrile-containing rubbers, combining the rubber with one or more micronized fluorine-containing polymers to produce a mixture, curing the mixture producing a cured mixture, and manufacturing the seal from the cured mixture.
- 21. The valve seal of claim 10, wherein the seal comprises 5-10 wt. % of one or more fluorine-containing polymers.
- 22. The valve seal of claim 10, wherein the fluorine-containing polymer is selected from the group consisting of polytetrafluoroethane, ethylenetetrafluoroethylene, perfluoroalkoxyalkane, fluorinated ethylene propylene, vinyldienefluoride, chlorinated ethylene tetrafluoroethylene and combinations thereof.
- 23. The valve seal of claim 10, wherein the nitrile-containing rubber is peroxide cured.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9715855 |
Jul 1997 |
GB |
|
Parent Case Info
This application is filed pursuant to 35 U.S.C §371 as a United States National Phase Application of International Application No. PCT/EP98/04681 filed Jul. 27, 1998, which claims priority from GB 9715855.4 filed Jul. 29, 1997.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/EP98/04681 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO99/06303 |
2/11/1999 |
WO |
A |
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Entry |
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