Claims
- 1. A valve for use with an aerosol container for dispensing a suspension or solution of a medicament in a liquid propellant contained therein, the valve comprising:a valve body defining a metering chamber, one or more gaskets suitable for slidingly engaging a valve stem, and the valve stem constructed from a mouldable plastic and one or more flurocarbon polymers, having a dispensing passage, and in communication with the metering chamber.
- 2. The valve according to claim 1, wherein the one or more fluorocarbon polymers comprises a polyetrafluoroethane.
- 3. The valve according to claim 2, wherein the one or more flurocarbon polymers comprises about 5 to 10% by weight of polyetrafluoroethane.
- 4. The valve according to claim 1, wherein the one or more flurocarbon polymers are selected from the group consisting of polyetrafluoroethane, ethylenetetrafluoroethylene, perfluoroalkoxyalkane, fluorinated ethylene propylene, vinyldionefluoride, chlorinated ethylene tetrafluoroethylene and combinations thereof.
- 5. A metering device comprising:a container in communication with a metering chamber, a valve stem constructed from a mouldable plastic and one or more flurocarbon polymers, the stem having a transfer passage adapted to dispense a quantity of an aerosol drug formulation comprising a medicament and a propellant, and, a valve body defining the metering chamber, one or more gaskets adapted to slidingly engage the valve stem.
- 6. The device according to claim 5, wherein the aerosol drug formulation includes one or more medicaments suspended in the liquid propellant, and wherein the liquid propellant is selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3-heptafluoropropane, and mixtures thereof.
- 7. The device according to claim 6, wherein the medicament is a member selected from the group consisting of salmeterol, fluticasone, salbutamol, beclomethasone, terbultaline, salts, esters and solvates thereof, and combinations thereof.
- 8. The valve according to claim 1, wherein the medicament is selected from the group consisting of a respiratory disorder medicament, an analgesic, an anginal preparation, an antiallergic, an antiinfective, an antihistamine, an anti-inflammatory, an antitussive, a bronchodilator, a diuretic, an anticholinergic, a hormone, a xanthine, a therapetuic protein, a therapeutic peptide and combinations thereof.
- 9. The valve according to claim 1, wherein the valve is suitable for dispensing an aerosol formulation comprising the medicament suspended in the liquid propellant, and wherein the medicament is selected from the group consisting of salmeterol, fluticasone, salbutamol, beclomethasone, terbutaline, salts, esters and solvates thereof, and combinations thereof.
- 10. The valve according to claim 9, further including a sampling chamber in communication with the metering chamber.
- 11. The valve according to claim 10, further including a sleeve within the valve body further defining the metering chamber.
- 12. The valve according to claim 11, further including a ring having a trough adapted to frictionally engage the valve body.
- 13. The valve according to claim 12 further including a return spring adapted to bias the valve stem.
- 14. The valve according to claim 9, wherein the propellant is selected from the group consisting of 1,1,1,2-tetrafluroethane, 1,1,1,2,2,3,3-heptafluropropane, and combinations thereof.
- 15. The valve according to claim 9, wherein the medicament is salmeterol xinafoate and the propellant is 1,1,1,2-tetrafluroethane.
- 16. The valve according to claim 9, wherein the medicament is a combination of fluticasone propionate and salmeterol xinafoate, and the propellant is 1,1,1,2-tetrafluroethane.
- 17. The valve according to claim 9, wherein the medicament is fluticasone propionate and the propellant is 1,1,1,2-tetrafluroethane.
- 18. The valve according to claim 9, wherein the medicament is salbutamol sulphate and the propellant is 1,1,1,2-tetrafluroethane.
- 19. The valve according to claim 9, wherein the medicament is beclomethasone dipropionate and the propellant is 1,1,1,2-tetrafluorethane.
- 20. The device according to claim 7, further including a sampling chamber in communication with metering chamber.
- 21. The device according to claim 20, further including a sleeve within the valve body further defining the metering chamber.
- 22. The device according to claim 21, further including a ring having a trough adapted to frictionally engage the valve body.
- 23. The device according to claim 22 further including a return spring adapted to bias the valve stem.
- 24. The device according to claim 5, wherein the medicament is suspended in the propellant, and wherein the propellant is selected from the group consisting of 1,1,2-tetrafluroethane, 1,1,1,2,3,3-heptafluropropane, and combinations thereof.
- 25. The device according to claim 23, wherein the medicament is salmeterol xinafoate and the propellant is 1,1,1,2-tetrafluoroethane.
- 26. The device according to claim 23, wherein the medicament is a combination of fluticasone propionate and salmeterol xinafoate, and the propellant is 1,1,1,2-tetrafluoroethane.
- 27. The device according to claim 23, wherein the medicament is fluticasone propionate and the propellant is 1,1,1,2-tetrafluroethane.
- 28. The device according to claim 23, wherein the medicament is salbutamol sulphate and the propellant is 1,1,1,2-tetrafluroethane.
- 29. The device according to claim 23, wherein the medicament is beclomethasone dipropionate and the propellant is 1,1,1,2-tetrafluoroethane.
- 30. A valve stem comprising:a mouldable plastic, and one or more mouldable flurocarbon polymers.
- 31. The valve stem of claim 30, wherein the stem is suitable for dispensing an aerosol drug formulation comprising a medicament and a propellant, wherein the drug is selected from the group consisting of salmeterol, fluticasone, salbutamol, beclomethasone, terbutaline, salts, esters and solvates thereof, and combinations thereof, and wherein the propellant is selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3-heptafluoropropane, and combinations thereof.
- 32. The valve stem of claim 30 comprising up to 20% by weight of the one or more mouldable flurocarbon polymers.
- 33. The valve stem of claim 30 comprising 5 to 10% by weight of the one or more mouldable flurocarbon polymers.
- 34. The valve stem of claim 30, wherein the one or more mouldable fluorocarbon polymers are selected from the group consisting of polyetrafluoroethane, ethylenetetrafluoroethylene, perfluoroalkoxyalkane, fluorinate ethylene propylene, vinyldionefluoride, chlorinated ethylene tetrafluoroethylene and combinations thereof.
- 35. A valve for use with an aerosol container for dispensing a suspension or solution of a medicament in a liquid propellant contained therein, the valve comprising:a valve body defining an aperture, and a valve stem constructed from one or more mouldable plastics and one or more flurocarbon polymers and having a dispensing passage, the valve stem adapted to slidingly engage a means for sealing the valve stem from the valve body.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9713382 |
Jun 1997 |
GB |
|
Parent Case Info
This application is filed pursuant to 35 U.S.C. § 371 as a United States National Phase Application of International Application No. PCT/EP98/03872 filed Jun, 25, 1998, which claims priorty from GB 9713382. June 26, 1997.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
102e Date |
371c Date |
PCT/EP98/03872 |
|
WO |
00 |
12/22/1999 |
12/22/1999 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO99/00315 |
1/7/1999 |
WO |
A |
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5450989 |
Gilroy |
Sep 1995 |
|
Foreign Referenced Citations (4)
Number |
Date |
Country |
0 634 166 A |
Jan 1995 |
EP |
0 642 992 A |
Mar 1995 |
EP |
2713299 A |
Jun 1995 |
FR |
2740527 A |
Apr 1997 |
FR |