Patent Application
20220409787
The present disclosure relates to a valve island for a, or respectively, of a hydraulic assembly in a dialysis machine, a hydraulic assembly with a valve island, and a dialysis machine with a corresponding hydraulic assembly comprising the valve island.
Dialysis devices/dialysis machines in medical technology usually include a hydraulic system or a hydraulic assembly in which valve units are used in which (electromagnetically switched) valves can selectively block or release the inputs and outputs of fluid line components of the dialysis machine in order to form a desired fluid flow path.
Conventional valve units for dialysis machines, such as those described in patent specification EP 895787, use a basic structure in which a balancing device of the dialysis machine is connected to the hydraulic system via solenoid valves. The solenoid valves serve as shut-off valves (on/off valves) for the inlets and outlets of the balance chambers of the balancing device. A central control unit drives the solenoid valves to form a desired fluid flow path.
However, the disadvantage of this solution is that the valve unit has many individual components and the assembly can reach a correspondingly large installation size.
In other solutions in medical technology, valve units of this type use central mounting sheets on which solenoid valves are fixed to form a central portion or valve island in the hydraulic system. According to prior art, for example, an insertion sheet is used on which the solenoid valve(s) is (are) mounted via a screw connection.
The disadvantage of these solutions, however, is that tools are always required for assembly and repair in order to fasten or disconnect the valves. This leads to an increase in the required installation space as well as an increase in the assembly steps.
The objective of the disclosure is therefore to provide a valve island for a generic hydraulic assembly/hydraulic system and a hydraulic assembly/hydraulic system with a valve island, in particular of or for a dialysis machine, with which the assembly effort can be reduced while at the same time reducing the installation size of the valve island.
Accordingly, the core of the present disclosure basically consists in the arrangement of a valve island with a base body, in/on which at least one fluid line (tube/fluid flow passage) is formed integrally/in one piece of material, at the at least one, preferably both axial ends (front side) of which in each case a hydraulic/pneumatic component, in particular a valve and further preferably a solenoid valve, is arranged/mounted via which a fluid connection between a respective (preferably end-side/front-side) fluid line opening and a component-side/valve-side branch line/passage can be opened and/or closed. The integral fluid line or fluid line formed in one piece of material with the base body furthermore has a number (at least one or more) of branch connections (spouts) which are spaced apart in the axial direction of the fluid line and, if applicable, are arranged circumferentially offset and are formed in one piece of material with the base body as well. Preferably, the spouts are fluid-separated from each other (e.g. by a partition wall in the integral fluid line) in such a way that in each case one spout is assigned only to one (solenoid) valve arranged at the front side, so that the two (solenoid) valves arranged axially at the end side are quasi media-separated. Furthermore, a further port may be formed in one piece of material on the integral fluid line, for example for the optional connection of an additional (solenoid) valve. Finally, a number (at least one) of mounting/holding means (projections, hooks, tabs, etc.) may be formed in one piece of material on the base body, which are provided and configured for fastening the base body to a separate holder/platform (not belonging to the valve island).
This constructive design of the valve island according to the disclosure makes it possible to configure its base body (including all components provided in one piece according to the above design) in a single section/one piece of material in a single manufacturing step, in particular using an injection molding or 3D printing process (rapid prototyping process). The connections on the integral fluid line that are (simultaneously) formed in the process allow (subsequent) assembly of (solenoid) valves, external fluid lines, temperature/electrical conductivity/pressure/fluid flow sensors and similar hydraulic/pneumatic components without the use of tools. Consequently, the manufacture of the valve island designed in this way is inexpensive and simple. Since the mounting means are preferably also integrated on the base body, installation of the valve island in a machine, preferably a dialysis machine, is quick.
According to one aspect of the invention, the valve island for a or of a hydraulic assembly is provided for a or of an extracorporeal blood treatment machine, preferably a dialysis machine. The valve island comprises the base body in which at least the one, in particular rigid, fluid flow passage (integral fluid line) is formed. The base body is, as configured above, preferably manufactured by additive manufacturing, or injection molding.
By using 3D printing or injection molding processes, the base body can be manufactured in a single step. The one or more integral fluid flow passages can be designed variably. In injection molding, interchangeable inserts can be used for this purpose. The at least one integral fluid flow passage is preferably provided rigidly and can therefore also assume a load-bearing function. Due to this self-supporting function, a conventional housing can be dispensed with for the valve island or the hydraulic assembly.
In a further development of the valve island, at least one valve mounting portion is formed/arranged (in one piece of material with the base body), which, as configured above, is provided at at least one axial end/end portion of the integral fluid flow passage. The valve mounting portion may be formed, for example, as a coil element, in particular a coil carrier for a solenoid valve, a solenoid valve itself, a valve seat, a control edge, a simple screw thread or bayonet fitting, or any other type of a valve mounting portion.
The valve mounting section or the solenoid valve may also be detachably/rotatably arranged on the base body, wherein the valve mounting portion is preferably manufactured additively or further preferably via injection molding. Different variants of the solenoid valve, the valve seat, etc., can be manufactured using an injection molding tool. In particular, a valve mounting portion formed in one piece of material on the base body (for example, in the form of the coil mounting body described above) reduces the number of individual parts that have to be attached to the base body. In other words, the number of individual parts or components required is reduced. In addition, this saves the assembly time required for this purpose. Furthermore, the installation space provided for this purpose, which has to be planned for an entire hydraulic assembly, can be efficiently reduced.
The valve mounting portion may be arranged together with a valve seat and perform the function of a media-separated valve to ensure contamination safety of the extracorporeal fluid circuit.
In a further development of the valve island, the at least one solenoid valve arranged on the front side of the integral fluid flow passage is held on the base body so that it can be rotated axially in steps of less than or equal to 45° in particular. This allows the cable routing for the valve portion to be individually adapted or oriented and also optimized in terms of material requirements and accessibility in the event of assembly and service. The valve is preferably mechanically secured to prevent it from turning automatically. In addition, cable length can be saved.
In a further development of the valve island, at least one, in particular hollow-cylindrical, coupling receptacle (referred to above as port) is formed in one piece with the base body, via which a (further) hydraulic component, in particular radially sealing/radially tight, is fluidically and form-fittingly connectable, is in particular connected, to the at least one fluid flow passage. The coupling receptacle may be injection molded onto the base body via injection molding or 3D printed. Radial-tight adaptation of other hydraulic components to the base body, such as a (further) valve, a tube coupling, a conductivity measurement sensor, a pressure measurement sensor, a temperature sensor, a pressure regulator, a throttle, a pressure reduction valve or the like, is thus possible.
In a further development of the valve island, the coupling receptacle (port), which is in particular in the form of a hollow cylinder, has on the circumferential side, in particular on the inner circumferential side, at least one, preferably a plurality, of depressions (longitudinal grooves) into which an element of a hydraulic component adapted for this purpose is insertable, is in particular inserted. In other words, the coupling receptacle has a connection portion formed with a certain profile, into/onto which the hydraulic component (further valve) can be inserted/fitted in a rotationally fixed manner as well as possibly in a predetermined rotational position with respect to the connection portion. In this way, rotation of the hydraulic elements relative to the coupling receptacle can be avoided. Such an anti-rotation device, for example via serrations (grooves), enables improved orienting of the hydraulic component with regard to the routing of the hydraulic lines, in particular hoses, and the routing of the cables or the wiring harness of the dialysis machine. The anti-rotation device can alternatively have different geometries with different dimensions. This can be used to implement an error prevention principle, such as the ‘poka-yoke principle’. In one case, for example, only one (single) orientation of the components may be possible. For axial securing of the hydraulic element in the coupling receptacle, a clip-shaped cotter pin can preferably be provided, which can be inserted into the coupling receptacle transversely to the latter and thus prevents axial removal/extraction of the hydraulic element out of/from the coupling receptacle.
In a further development of the valve island, at least one spout is formed in one piece of material with the base body, via which an external fluidic line is fluidically connectable, is in particular connected, to the at least one integral fluid flow passage. The at least one spout may be molded onto the base body via injection molding or printed on via 3D printing.
The diameter of the at least one spout can be variable. The at least one spout is provided for connecting or plugging on fluidic lines with an inner diameter of in particular 2 to 6 mm. The fluidic line is in particular a tube, but may alternatively be a pipe. The base body preferably has 2 to 3 or 4 to 6 spouts. The number of spouts can be extended to a maximum of 7.
In a further development of the valve island, at least one fluidic and possibly also mechanical connecting portion is formed integrally with the base body, via which a preferably sensory component, in particular a hydraulic sensor component, is fluidically and possibly also mechanically connectable, is in particular connected. This enables radially sealed/radially tight adaptation or connection of sensor components to the base body, such as a conductivity measurement sensor, a pressure measurement sensor, a temperature sensor or the like. Alternatively, other hydraulic components such as a (further) valve, a tube coupling, a pressure regulator, a throttle, a pressure reducing valve or the like can be connected.
In a further development of the valve island, at least one connecting portion is formed on the base body, via which the valve island is connectable, is in particular connected, to a connecting portion of the hydraulic assembly or of a mounting adapter matched thereto.
In a further development of the valve island, at least two recesses, in particular two bores, are formed on the base body through which fixing means, in particular cable ties, are passable. Alternatively, a different number of bores, for example four bores, can be formed/provided on the base body to enable fixing adapted to the corresponding circumstances. The fixing means are intended to provide strain relief for at least one cable or cable harness.
In a further development of the valve island, at least one receptacle, in particular a plug window, is formed in the base body, in which a plug housing is receivable, is in particular received. Alternatively, two plug windows may be formed on the base body, each of which receives a plug housing. The plug window enables a plug housing of a load line or a plug housing of a sensor line to be received.
In a further development of the valve island, the hydraulic component is a valve, in particular a solenoid valve, which is connected fluidically and form-fittingly (on the front side) to the at least one integrated fluid flow passage, in particular radially tightly, via the coupling receptacle arranged/formed on the end side of the integrated fluid flow passage. In a further development of the valve island, the valve has a valve seat which is manufactured in particular by additive manufacturing or injection molding.
In a further development of the valve island, the valve has a coupling portion, in particular a frustoconical coupling portion, which is inserted into the coupling receptacle described above and is axially fastened therein via a mounting element, in particular a mounting clip (split pin as defined above). The coupling portion may be manufactured by injection molding or additive manufacturing. By inserting the frustoconical coupling portion into the coupling receptacle, a fluidic, radially tight connection is established. Via the fluidic, radially tight connection, the fluid flow channels of the base body and the valve are connected. The mounting element (split pin) can be manufactured via injection molding or additive manufacturing, or can be produced as a stamped bent part or as a wire bent part.
In a further development of the valve island, the aforementioned coupling portion has an element, in particular a projection, adapted for the at least one depression of the coupling receptacle. The projection of the coupling portion engages in the depression of the coupling receptacle. This prevents the valve portion from rotating in relation to the base body.
In a further development of the valve island, the coupling portion has a sealing element, in particular an O-ring, at a section, in particular at the circumference of a tip end, for sealing a formed fluid flow passage.
In a further development of the valve island, the valve has a valve portion, in particular a coil element. The valve portion can be designed axially or angled in relation to the coupling portion, for example angled by about 90°.
In a further development of the valve island, the valve portion is axially rotatable in steps, in particular of less than or equal to 45°.
In a further development of the valve island, the valve has at least one spout (valve-side branch passage as defined above) via which an external fluid line, in particular a pipe or tube, is fluidically connectable, is in particular connected, to the at least one integral fluid flow passage.
The at least one spout may be designed axially or angled in relation to the coupling portion and/or the valve portion, for example angled by about 90°.
The valve may have two or more spouts that are formed axially or angled relative to each other, for example angled by about 90°.
In an alternative further development of the valve island, the valve has a fluidic and possibly also mechanical connecting portion via which a component, in particular a hydraulic component, is fluidically and possibly also mechanically connectable, in particular connected, to the valve.
Examples of a hydraulic component are, for example, another valve, in particular a snap-in valve, a tube coupling, a conductivity measuring sensor, a pressure measuring sensor, a temperature sensor, a pressure regulator, a throttle, a pressure reducing valve or similar sensory component.
The fluidic and possibly also mechanical connecting portion may be designed axially or angled, for example angled by about 90°, in relation to the coupling portion and/or the valve portion and/or the at least one spout.
In a further development of the valve island, a mixing element for mixing fluids is integrated in a fluid flow passage of the/a valve. The valve is preferably a hydraulic check valve or a hydraulic solenoid valve.
In an alternative further development of the valve island, a mixing element is integrated in a valve seat of the valve. The valve is preferably a hydraulic solenoid valve, in particular the snap-in valve.
In one further embodiment of the valve island, the mixing element is tubular and extends along its length in the axial direction within the fluid flow passage of the valve.
In a further embodiment of the valve island, the hydraulic component is a mixing element that is fluidically and form-fittingly connected to a fluid flow passage or the at least one fluid flow passage via the/a coupling receptacle.
In a further development of the valve island in which the hydraulic component is a mixing element, the mixing element preferably has a full-cylinder shape. A plurality of flow passages are formed within the solid cylindrical mixing element in the direction of extension of the mixing element. The flow passages are arranged parallel to each other and parallel to a central axis of the mixing element to form a multiple passage for a fluid flowing therethrough. The flow passages extend in the axial direction of the fluid flow passage of the valve and/or fluid flow direction.
In a particularly preferred further embodiment of the valve island, a portion of the plurality of flow passages, in particular eight, are arranged in close proximity to the outer circumference of the mixing element in the circumferential direction at uniform intervals. Another part of the plurality of flow passages, in particular four, are evenly spaced in the immediate vicinity of the central axis in the circumferential direction. The radial distances of the one part of the plurality of flow passages from the central axis are uniform in each case. Likewise, the radial distances of the other part of the plurality of flow passages from the central axis are uniform.
In a further embodiment of the valve island, the cross-sectional shape of one part of the plurality of flow passages is different from the cross-sectional shape of the other part of the plurality of flow passages. The cross-sectional shape of the one portion of the plurality of flow passages is preferably circular. The cross-sectional shape of the other part of the plurality of flow passages is preferably polygonal, in particular hexagonal.
In a further development of the valve island, the mixing element, in particular a frustoconical coupling portion, is inserted into the coupling receptacle and is secured therein via a mounting element, in particular a mounting clip.
In a further development of the valve island, the mixing element is manufactured by additive manufacturing or injection molding.
In a further development of the valve island, the mixing element is manufactured in one piece with the coupling portion by injection molding or additive manufacturing. The mixing element may serve as a first component, for example as a pre-molded part, in order to subsequently be connected, in particular overmolded, in one piece with a second component, in particular the coupling portion, by injection molding. The material of the first component and the second component may be different.
By inserting the frustoconical coupling portion into the coupling receptacle, a fluidic, radially tight connection is established. Via the fluidic, radially tight connection, the fluid flow channels of the base body and the mixing element are connected.
The mixing element may be directly integrated into a sub-assembly which comprises, for example, a valve, in particular a check valve, a mounting clip and a conductivity measuring sensor.
The mixing element may be secured against rotation about the longitudinal/central axis of the fluid flow passage of the valve by an anti-rotation device.
Another aspect of the invention is a hydraulic assembly for one or more extracorporeal blood treatment machines comprising a carrier having indirectly or directly arranged thereon at least one valve island according to a first aspect.
The carrier is suitable for modular assembly of at least one component, but preferably a plurality of components. The carrier may be a tower, in particular an assembly tower.
In a further development of the hydraulic assembly, the carrier has, in particular only, one surface or plane on which the one or more valve islands and/or other components is or are arranged. This has the advantage that during maintenance or repair of the hydraulic assembly, there are no components blocking the way, which may have to be dismantled in order to access a particular valve island and/or other component.
In a further development of the hydraulic assembly, the at least one valve island and/or other components in the common surface or plane or assembly plane are mountable or dismountable from a common side.
In a further development of the hydraulic assembly, the carrier has at least one adapted connecting portion that is connected to the connecting portion of the base body, in particular without tools.
This connection can be realized in particular according to the keyhole principle, in which an at least male connection element can be inserted (hooked) into an at least female connection receptacle. However, other tool-free connection variants such as a plug-in principle or the like are also possible.
In a further development of the hydraulic assembly, it has a mounting adapter with an adapted connecting portion that is connected to the connecting portion of the base body, in particular without tools, and has at least one secondary connecting portion that is connected to the carrier.
This connection can also be realized in particular according to the keyhole principle, in which an at least male connection element can be inserted (hooked) into an at least female connection receptacle. However, other tool-free connection variants are also possible, such as a plug-in principle, hook-in principle or the like, as already configured above. The secondary connecting portion of the mounting adapter can be a force-fit or tool-free connection to the carrier.
In a further development of the hydraulic assembly, the mounting adapter is a spacer, via which the base body is arranged approximately parallel to the surface or respectively a mounting angle, via which the base body is arranged at an angle to the surface or respectively the plane.
In a further development of the hydraulic assembly, the connection of the valve island to the carrier or the mounting adapter is locked, in particular via a locking element. The locking element can be an expansion clip, wedge pin or the like.
In a further development of the hydraulic assembly, the carrier is an assembly tower. The assembly tower has a mounting plate or the like that serves as a mounting surface or mounting level for the at least one valve island and/or other hydraulic components. The mounting plate may be provided in a U-shaped frame or a box-shaped housing. The mounting plate may be arranged centrally and parallel between the front and rear walls of the housing, so that a front and rear space is formed which is bounded by the mounting plate. Further valve islands or other hydraulic components may be mounted or suspended on the inner surfaces formed in the respective space, preferably without the use of tools.
In a further development of the hydraulic assembly, the mounting angle is mounted on an insertion sheet that is suitable for insertion or sliding into the hydraulic assembly, in particular the assembly tower.
In a further development of the hydraulic assembly, the latter has at least one sub-assembly which is arranged indirectly or directly on the carrier, in particular by hanging and/or screwing, in deviation from the valve island(s).
The sub-assembly forms a further mounting surface or plane which is planar to the mounting surface or plane of the carrier. On the mounting surface or plane of the carrier, for example, a flat recess can be provided at the edge into which the sub-assembly is or will be inserted in a planar manner.
In a further development of the hydraulic assembly, the sub-assembly has at least one balance chamber. Hydraulic components such as valves, in particular solenoid valves, can be connected to the balance chamber. The connection can be fastened via a mounting element, in particular a mounting clip. The balance chambers can be manufactured additively or via injection molding.
The objects, aspects and advantages of the present invention stated above are further illustrated by the following detailed description of the accompanying drawing.
Configuration examples of the present disclosure are described below based on the accompanying figures.
The valve island 1 has a base body 2. The base body 2 is manufactured using additive manufacturing or injection molding. The base body 2 comprises (has) a fluid flow passage 3 which is integral/formed in one piece with the base body 2 (internal, rigid) and thus fulfills a self-supporting function of the valve island 1. The base body 2 furthermore has a plurality of spouts or connection nozzles 4 integral/formed in one piece with the base body 2, which are connected to the fluid flow passage 3, preferably in a T-shaped (fluidically connected) manner, and are provided and configured for the connection of external hydraulic lines or tubes. The spouts 4 are preferably molded onto the base body 2 and point radially outward from the fluid flow passage 3.
In/on the fluid flow passage 3, a respective axial valve seat (not shown) is preferably provided or formed within the two axial ends/end portions of the fluid flow passage 3 or at the two axial ends/end portions of the fluid flow passage 3. Each valve seat is opened and/or closed by a movable valve element (valve piston), which is driven by a coil element (electric valve coil) 5 arranged at the base body 2 or fluid flow passage 3, respectively. The coil elements 5 of the two valves arranged axially at the ends are located axially outside at the axial ends/end portions of the fluid flow passage 3. The coil elements 5 are held on the base body 2 rotatably in 45° degree steps or alternatively in steps smaller than 45° about their axis, i.e. about the longitudinal axis of the fluid flow passage 3.
The base body 2 also has a hollow cylindrical coupling receptacle (port) 6 at/in the area of the valve seat, which is suitable for fluidic and form-fitting (mechanical) connection with other hydraulic components. The coupling receptacle 6 is preferably molded onto the base body 2 and points radially (preferably in a T-shape) outward from the fluid flow passage 3. The hollow-cylindrical coupling receptacle 6 has depressions 7 on the inner circumference at preferably equal circumferential distances, which are suitable and provided for receiving an element of another hydraulic component adapted thereto. The base body 2 also has (through) bores 8 which extend completely through the base body 2 laterally next to the fluid flow passage 3 and through which fixing means such as screws, rivets or bands (not shown) are insertable.
In other words, the valve island according to the disclosure consists of the base body 2, which comprises both the fluid flow passage 3 and a (block-like) portion with the bores 8 formed therein in one piece of material. The fluid flow passage 3 has two axially spaced ends/end portions to which the aforementioned solenoid valves are preferably mounted so as to be rotatable about the longitudinal axis of the passage. Each valve has an electrically activatable valve coil, via which a respective movable valve body is movable for opening and closing the valve, so as to fluidly connect and/or fluidly disconnect the fluid flow passage 3 with a branch line. The valve seat, which is openable and closable by the valve body, is formed either directly on the front side of the fluid flow passage 3 or integrally in the solenoid valve. As an alternative to the rotatability of the valve-internal valve/solenoid coil described above, this (or its receiving housing) can also be formed integrally with the base body 2.
The other side of the valve island 1 shown in
The coupling portion 15 of the snap-in valve 14 in
The various configurations of the snap-in valve 14 include one or a plurality of spouts 19 connected to the internal fluid flow passage of the snap-in valve 14 and provided for connection of external hydraulic lines or tubes. Further, in addition to the one or more spouts 19, some of the configurations of the snap-in valve 14 may include a connecting portion 20 suitable and provided for connection/coupling of, for example, sensors or indicating instruments.
The configurations a) to e) in
A bottom portion of the coupling portion 15 of the snap-in valve 14 (corresponding to an end disk axially bounding the coupling portion 15) has a circular front surface facing the coupling portion 15 in the axial direction, and in the center of which the fluid flow passage of the snap-in valve 14 is arranged with a diameter smaller than that of the circular front surface. Two projections 21 are arranged on the circular front surface, which project in the axial direction from the circular front surface toward the coupling portion 15 and also extend in the radial direction, as shown in
The connecting portion 24 of the carrier has two female connection receptacles 25, which are arranged at a distance one above the other as shown in
The valve locking element 23 is conical and suitable for locking the valve island 1 to the connecting portion 24 of the carrier. In order to lock the valve island 1, the valve locking element 23 is inserted/pressed through a U-shaped section of the connecting base plate 12 of the valve island 1 (see
The valve island 1 of the second configuration example differs from the valve island 1 of the first configuration example by the base body 27, on which a further (second), independent fluid flow passage is formed, which is preferably connected in one piece of material to the base body 27 axially parallel to the first fluid flow passage on the same or an opposite side of the base body. In other words, the base body 27 serves, among other things, as a middle or connecting part between the parallel-spaced fluid flow passages.
The two fluid flow passages according to
In this case, the mounting adapter 31 serves as a spacer to create a distance between the valve island 1 and the connecting portion 32 of the carrier. This is necessary due to the special design of the mounting side (the side facing the carrier) of the valve island 1, on which the fluidic connecting portions 9 are arranged in the second configuration example. Likewise, the distance is required for one of the two stretch valves connected to the coupling receptacle 6, in which the spool body 17 of the snap-in valve is angled 90° to the coupling portion 15 of the snap-in valve in the direction towards the carrier.
On a side facing the valve island, the mounting adapter 31 has at least one of the male connection elements (hooks) 13 described above, unlike the valve island 1 of the first configuration example, in which the connecting base plate 12 of the base body 2 has the male connection elements 13. The side of the mounting adapter 31 facing the carrier further has a number of (preferably three) bores suitable for mounting on the carrier, on which congruently correspondingly similar bores are provided.
An assembly tower (housing portion of the dialysis machine) 36 preferably has a mounting plate 37 that serves as a mounting surface or mounting plane/carrier for the valve island 1 and possibly also for the balance chambers 35. The mounting plate 37 is provided in a U-shaped frame of the assembly tower 36. The space defined/surrounded by the assembly tower 36 is divided by the mounting plate 37 into a front and a rear space section. The valve island 1 is mounted to the mounting plate 37 in an area, according to
The balance chambers 35 are mounted on a plate-like sub-assembly 38, which is mounted in a planar manner in the mounting plate 37 to form a common plane with the mounting plate 37.
| Number | Date | Country | Kind |
|---|---|---|---|
| 10 2019 132 178.6 | Nov 2019 | DE | national |
This application is the United States national stage entry of International Application No. PCT/EP2020/083282, filed Nov. 25, 2020, and claims priority to German Application No. 10 2019 132 178.6. The contents of International Application No. PCT/EP2020/083282 and German Application No. 10 2019 132 178.6 are incorporated by reference herein in their entireties.
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/EP2020/083282 | 11/25/2020 | WO |
