Claims
- 1. A racemic or optically active compound of the formula
- Q--C.sub.n H.sub.2n --NH--R
- wherein
- Q is ##STR340## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino;
- R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl; and
- R.sub.1 and R.sub.2, together, are methylenedioxy or ethylenedioxy;
- n is an integer from 2 to 6, inclusive; and
- R is ##STR341## where R.sub.4 is hydrogen, methyl or ethyl;
- R.sub.5, R.sub.6 and R.sub.7, which may be identical to or different from each other, are each hydrogen, halogen, hydroxymethyl, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, --CONHR.sub.3, --CONHOH, --COOR.sub.3, R.sub.8 O--, methylsulfonylmethyl or, when one or two of R.sub.5 through R.sub.7 are other than halogen or trifluoromethyl, also --NR.sub.3 R.sub.9,
- where
- R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms,
- R.sub.8 is hydrogen, alkanoyl of 1 to 20 carbon atoms, or benzyl, and
- R.sub.9 is hydrogen, lower alkanoyl, methanesulfonyl, carbamoyl, dimethylsulfamoyl, or alkoxycarbonyl of 2 to 5 carbon atoms, and
- R.sub.5 and R.sub.6, together are --O--CH.sub.2 --O--, --O--CH.sub.2 CH.sub.2 --O--, --CH.dbd.CH--CH.dbd.CH--, --O--CH.sub.2 --CONH--, --CH.sub.2 --CH.sub.2 --CONH-- or --O--CO--NH--,
- or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 2. A compound of claim 1, which is 1-(3-methanesulfonamido-4-hydroxy-phenyl)-2-{1,1-dimethyl-3-[3-(3,4-dimethoxy-phenyl)-imidazolidin-2-one-1-yl]-n-propyl-amino}-ethanol or a non-toxic, pharmacologically acceptable acid addition salt thereof.
- 3. A vasodilating or antidepressant pharmaceutical dosage unit composition consisting essentially of an inert pharmaceutical carrier and an effective vasodilating or anti-depressant amount of a compound of claim 1.
- 4. The method of dilating the blood vessels or relieving depression in a warm-blooded animal in need thereof, which comprises perorally, parenterally or rectally administering to said animal an effective vasodilating or anti-depressant amount of a compound of claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2609645 |
Mar 1976 |
DEX |
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CROSS REFERENCE TO RELATED APPLICATION
This application is a division of U.S. Pat. application Ser. No. 026,608, filed Apr. 3, 1979, which in turn is a continuation-in-part of U.S. patent application Ser. No. 773,394 filed Mar. 2, 1977, now U.S. Pat. No. 4,154,829, incorporated herein by reference.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3355457 |
Wright et al. |
Nov 1967 |
|
3925383 |
Van Gelder et al. |
Dec 1975 |
|
3994901 |
Nakagawa et al. |
Nov 1976 |
|
4081447 |
Prasad et al. |
Mar 1978 |
|
Foreign Referenced Citations (3)
Number |
Date |
Country |
1516714 |
Mar 1968 |
FRX |
995366 |
Jun 1965 |
GBX |
1345075 |
Jan 1974 |
GBX |
Non-Patent Literature Citations (1)
Entry |
Wright, W., et al., J. Med. Chem., 9, 852-857 (1966). |
Divisions (1)
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Number |
Date |
Country |
Parent |
26608 |
Apr 1979 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
773394 |
Mar 1977 |
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