Patent Grant
11819699
The present disclosure relates to implantable medical devices, systems, and methods. In particular, the present disclosure relates to implantable medical devices, systems, and methods for ventricle-from-atrium (VfA) cardiac therapy, including single chamber or multiple chamber pacing (e.g., dual or triple chamber pacing), atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy.
The cardiac conduction system includes the sinus atrial (SA) node, the atrioventricular (AV) node, the bundle of His, bundle branches and Purkinje fibers. A heartbeat is initiated in the SA node, which may be described as the natural “pacemaker” of the heart. An electrical impulse arising from the SA node causes the atrial myocardium to contract. The signal is conducted to the ventricles via the AV node which inherently delays the conduction to allow the atria to stop contracting before the ventricles begin contracting thereby providing proper AV synchrony. The electrical impulse is conducted from the AV node to the ventricular myocardium via the bundle of His, bundle branches, and Purkinje fibers.
Patients with a conduction system abnormality, such as poor AV node conduction or poor SA node function, may receive an implantable medical device (IMD), such as a pacemaker, to restore a more normal heart rhythm and AV synchrony. Some types of IMDs, such as cardiac pacemakers, implantable cardioverter defibrillators (ICDs), or cardiac resynchronization therapy (CRT) devices, provide therapeutic electrical stimulation to a heart of a patient via electrodes on one or more implantable endocardial, epicardial, or coronary venous leads that are positioned in or adjacent to the heart. The therapeutic electrical stimulation may be delivered to the heart in the form of pulses or shocks for pacing, cardioversion, or defibrillation. In some cases, an IMD may sense intrinsic depolarizations of the heart, and control the delivery of therapeutic stimulation to the heart based on the sensing.
Delivery of therapeutic electrical stimulation to the heart can be useful in addressing cardiac conditions such as ventricular dyssynchrony that may occur in patients. Ventricular dyssynchrony may be described as a lack of synchrony or a difference in the timing of contractions in different ventricles of the heart. Significant differences in timing of contractions can reduce cardiac efficiency. CRT, delivered by an IMD to the heart, may enhance cardiac output by resynchronizing the electromechanical activity of the ventricles of the heart. CRT is sometimes referred to as “triple chamber pacing” because of pacing the right atrium, right ventricle, and left ventricle.
Cardiac arrhythmias may be treated by delivering electrical shock therapy for cardioverting or defibrillating the heart in addition to cardiac pacing, for example, from an ICD, which may sense a patient's heart rhythm and classify the rhythm according to an arrhythmia detection scheme in order to detect episodes of tachycardia or fibrillation. Arrhythmias detected may include ventricular tachycardia (VT), fast ventricular tachycardia (FVT), ventricular fibrillation (VF), atrial tachycardia (AT) and atrial fibrillation (AT). Anti-tachycardia pacing (ATP), a painless therapy, can be used to treat ventricular tachycardia (VT) to substantially terminate many monomorphic fast rhythms. While ATP is painless, ATP may not deliver effective therapy for all types of VTs. For example, ATP may not be as effective for polymorphic VTs, which has variable morphologies. Polymorphic VTs and ventricular fibrillation (VFs) can be more lethal and may require expeditious treatment by shock.
Dual chamber medical devices are available that include a transvenous atrial lead carrying electrodes that may be placed in the right atrium and a transvenous ventricular lead carrying electrodes that may be placed in the right ventricle via the right atrium. The dual chamber medical device itself is generally implanted in a subcutaneous pocket and the transvenous leads are tunneled to the subcutaneous pocket. A dual chamber medical device may sense atrial electrical signals and ventricular electrical signals and can provide both atrial pacing and ventricular pacing as needed to promote a normal heart rhythm and AV synchrony. Some dual chamber medical devices can treat both atrial and ventricular arrhythmias.
Intracardiac medical devices, such as a leadless pacemaker, have been introduced or proposed for implantation entirely within a patient's heart, eliminating the need for transvenous leads. A leadless pacemaker may include one or more electrodes on its outer housing to deliver therapeutic electrical signals and/or sense intrinsic depolarizations of the heart. Intracardiac medical devices may provide cardiac therapy functionality, such as sensing and pacing, within a single chamber of the patient's heart. Single chamber intracardiac devices may also treat either atrial or ventricular arrhythmias or fibrillation. Some leadless pacemakers are not intracardiac and may be positioned outside of the heart and, in some examples, may be anchored to a wall of the heart via a fixation mechanism.
In some patients, single chamber devices may adequately address the patient's needs. However, single chamber devices capable of only single chamber sensing and therapy may not fully address cardiac conduction disease or abnormalities in all patients, for example, those with some forms of AV dyssynchrony or tachycardia. Dual chamber sensing and/or pacing functions, in addition to ICD functionality in some cases, may be used to restore more normal heart rhythms.
Various embodiments of the present disclosure relate to implantable medical devices, systems, and methods for VfA cardiac therapy, including single or multiple chamber pacing (e.g., dual or triple chamber pacing), atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. A tissue-piercing electrode is implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to facilitate the VfA cardiac therapy.
In one aspect, the present disclosure relates to an implantable medical device that includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to at least one of deliver cardiac therapy to and sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode positionable within the right atrium to at least one of deliver cardiac therapy and sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to monitor electrical activity of the right atrium using the right atrial electrode and deliver atrioventricular synchronous pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored electrical activity of the right atrium.
In another aspect, the present disclosure relates to a method that includes monitoring activity of the right atrium of a patient's heart using a right atrial electrode or a right atrial motion detector and delivering atrioventricular synchronous pacing using at least a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body including pacing one or both ventricles using at least the tissue-piercing electrode based on the monitored activity of the right atrium.
In another aspect, the present disclosure relates to an implantable medical device that includes a housing extending from a proximal end region to a distal end region. The device also includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode leadlessly coupled to the distal end region of the housing and implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode leadlessly coupled to the housing and positionable within the right atrium to deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit within the housing operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit within the housing operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry within the housing operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to monitor electrical activity of the right atrium using the right atrial electrode and deliver atrioventricular synchronous pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored electrical activity of the right atrium.
In another aspect, the present disclosure relates to an implantable medical device that includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to at least one of deliver cardiac therapy to and sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The tissue-piercing electrode also includes a right atrial motion detector positionable within the right atrium to sense mechanical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to monitor mechanical activity of the right atrium using the right atrial motion detector and deliver atrioventricular synchronous pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored mechanical activity of the right atrium.
In another aspect, the present disclosure relates to an implantable medical device that includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to at least one of deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode positionable within the right atrium to at least one of deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to monitor at least one of electrical activity of the right atrium using the right atrial electrode and electrical activity of the left ventricle using the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The controller is also configured to deliver cardiac resynchronization pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored electrical activity.
In another aspect, the present disclosure relates to a method that includes monitoring at least one of electrical activity of the right atrium of a patient's heart using a right atrial electrode and electrical activity of the left ventricle using a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The method also includes delivering cardiac resynchronization pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body including pacing one or both ventricles based on the monitored electrical activity.
In another aspect, the present disclosure relates to an implantable medical device that includes a housing extending from a proximal end region to a distal end region. The implantable medical device also includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode leadlessly coupled to the distal end region of the housing and implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode leadlessly coupled to the housing and positionable within the right atrium to deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit within the housing operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit within the housing operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry within the housing operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to monitor at least one of electrical activity of the right atrium using the right atrial electrode and electrical activity of the left ventricle using the tissue-piercing electrode in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The controller is further configured to deliver cardiac resynchronization pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored electrical activity.
In another aspect, the present disclosure relates to an implantable medical device that includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to at least one of deliver cardiac therapy to and sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial motion detector positionable within the right atrium to sense mechanical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to monitor mechanical activity of the right atrium using the right atrial motion detector and deliver cardiac resynchronization pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored mechanical activity of the right atrium.
In another aspect, the present disclosure relates to an implantable medical device that includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode positionable within the right atrium to deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to: monitor electrical activity of the right atrium using the right atrial electrode; monitor electrical activity of the left ventricle using the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium; and deliver tachycardia therapy based on the monitored electrical activities of the right atrium and the left ventricle.
In another aspect, the present disclosure relates to a method that includes monitoring electrical activity of the right atrium of a patient's heart using a right atrial electrode; monitoring electrical activity of the left ventricle of the patient's heart using a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium; and deliver tachycardia therapy based on the monitored electrical activities of the right atrium and the left ventricle.
In another aspect, the present disclosure relates to an implantable medical device that includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode positionable within the right atrium to deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to: monitor electrical activity of the right atrium using the right atrial electrode; monitor electrical activity of the left ventricle using the tissue-piercing electrode implanted to sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body; and determine tachycardia of the patient's heart based on the monitored electrical activities of the right atrium and the left ventricle.
In another aspect, the present disclosure relates to an implantable medical device that includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode positionable within the right atrium to deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to deliver at least one of anti-tachycardia pacing therapy using the plurality of electrodes and shock therapy using a separate medical device.
The above summary is not intended to describe each embodiment or every implementation of the present disclosure. A more complete understanding will become apparent and appreciated by referring to the following detailed description and claims taken in conjunction with the accompanying drawings. In other words, these and various other features and advantages will be apparent from a reading of the following detailed description.
This disclosure relates to implantable medical devices, systems, and methods for VfA cardiac therapy, including single or multiple chamber pacing (e.g., dual or triple chamber pacing), atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. Although reference is made herein to implantable medical devices, such as a pacemaker or ICD, the methods and processes may be used with any medical devices, systems, or methods related to a patient's heart. Various other applications will become apparent to one of skill in the art having the benefit of the present disclosure.
It may be beneficial to provide an implantable medical device that is free of transvenous leads (e.g., a leadless device). It may also be beneficial to provide an implantable medical device capable of being used for various cardiac therapies, such as single or multiple chamber pacing (e.g., dual or triple chamber pacing), atrioventricular synchronous pacing, asynchronous pacing, triggered pacing, cardiac resynchronization pacing, or tachycardia-related therapy. Further, it may be beneficial to provide a system capable of communicating with a separate medical device, for example, to provide triggered pacing or to provide shock therapy in certain cases of tachycardia.
The present disclosure provides an implantable medical device including a tissue-piercing electrode and optionally a right atrial electrode and/or a right atrial motion detector. The tissue-piercing electrode may be implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. In a leadless implantable medical device, the tissue-piercing electrode may leadlessly extend from a distal end region of a housing of the device, and the right atrial electrode may be leadlessly coupled to the housing (e.g., part of or positioned on the exterior of). The right atrial motion detector may be within the implantable medical device. In a leaded implantable medical device, one or more of the electrodes may be coupled to the housing using an implantable lead. When the device is implanted, the electrodes may be used to sense electrical activity in one or more atria and/or ventricles of a patient's heart. The motion detector may be used to sense mechanical activity in one or more atria and/or ventricles of the patient's heart. In particular, the activity of the right atrium and the left ventricle may be monitored and, optionally, the activity of the right ventricle may be monitored. The electrodes may be used to deliver cardiac therapy, such as single chamber pacing for atrial fibrillation, atrioventricular synchronous pacing for bradycardia, asynchronous pacing, triggered pacing, cardiac resynchronization pacing for ventricular dyssynchrony, anti-tachycardia pacing, or shock therapy. Shock therapy may be initiated by the implantable medical device. A separate medical device, such as an extravascular ICD, which may also be implanted, may be in operative communication with the implantable medical device and may deliver an electrical shock in response to a trigger, such as a signaling pulse (e.g., triggering, signaling, or distinctive electrical pulse) provided by the device.
Reference will now be made to the drawings, which depict one or more aspects described in this disclosure. However, it will be understood that other aspects not depicted in the drawings fall within the scope of this disclosure. Like numbers used in the figures refer to like components, steps, and the like. However, it will be understood that the use of a reference character to refer to an element in a given figure is not intended to limit the element in another figure labeled with the same reference character. In addition, the use of different reference characters to refer to elements in different figures is not intended to indicate that the differently referenced elements cannot be the same or similar.
Although the present disclosure describes leadless and leaded implantable medical devices, reference is first made to
The device 10 may be described as a leadless implantable medical device. As used herein, “leadless” refers to a device being free of a lead extending out of the patient's heart 8. In other words, a leadless device may have a lead that does not extend from outside of the patient's heart to inside of the patient's heart. Some leadless devices may be introduced through a vein, but once implanted, the device is free of, or may not include, any transvenous lead and may be configured to provide cardiac therapy without using any transvenous lead. A leadless VfA device, in particular, does not use a lead to operably connect to an electrode in the ventricle when a housing of the device is positioned in the atrium. A leadless electrode may be coupled to the housing of the medical device without using a lead between the electrode and the housing.
The device 10 may include one or more dart electrodes 12 having a straight shaft extending from the distal end region of device 10, through the atrial myocardium and the central fibrous body, and into the ventricular myocardium 14 or along the ventricular septum, without perforating entirely through the ventricular endocardial or epicardial surfaces. In other words, the dart electrode 12 may not pierce through the ventricular wall into the blood volume. The dart electrode 12 may carry an electrode at the distal end region of the shaft for positioning the electrode within the ventricular myocardium for sensing ventricular signals and delivering ventricular pulses (e.g., to depolarize the left ventricle to initiate a contraction of the left ventricle). In some examples, the electrode at the distal end region of the shaft is a cathode electrode provided for use in a bipolar electrode pair for pacing and sensing. While the implant region 4 is shown in
The cardiac therapy system 2 may also include a separate medical device 50 (depicted diagrammatically in
In the case of shock therapy, e.g., the defibrillation shocks provided by the defibrillation electrode of the defibrillation lead, separate medical device 50 (e.g., extravascular ICD) may include a control circuit that uses a therapy delivery circuit to generate defibrillation shocks having any of a number of waveform properties, including leading-edge voltage, tilt, delivered energy, pulse phases, and the like. The therapy delivery circuit may, for instance, generate monophasic, biphasic, or multiphasic waveforms. Additionally, the therapy delivery circuit may generate defibrillation waveforms having different amounts of energy. For example, the therapy delivery circuit may generate defibrillation waveforms that deliver a total of between approximately 60-80 Joules (J) of energy for subcutaneous defibrillation.
The separate medical device 50 may include a sensing circuit. The sensing circuit may be configured to obtain electrical signals sensed via one or more combinations of electrodes and process the obtained signals. The components of the sensing circuit may be analog components, digital components, or a combination thereof. The sensing circuit may, for example, include one or more sense amplifiers, filters, rectifiers, threshold detectors, analog-to-digital converters (ADCs) or the like. The sensing circuit may convert the sensed signals to digital form and provide the digital signals to the control circuit for processing or analysis. For example, the sensing circuit may amplify signals from sensing electrodes and convert the amplified signals to multi-bit digital signals by an ADC. The sensing circuit may also compare processed signals to a threshold to detect the existence of atrial or ventricular depolarizations (e.g., P- or R-waves) and indicate the existence of the atrial depolarization (e.g., P-waves) or ventricular depolarizations (e.g., R-waves) to the control circuit.
The device 10 and the separate medical device 50 may cooperate to provide cardiac therapy to the patient's heart 8. For example, the device 10 and the separate medical device 50 may be used to detect tachycardia, monitor tachycardia, and/or provide tachycardia-related therapy. For example, the device 10 may communicate with the separate medical device 50 wirelessly to trigger shock therapy using the separate medical device 50. As used herein, “wirelessly” refers to an operative coupling or connection without using a metal conductor between the device 10 and the separate medical device 50. In one example, wireless communication may use a distinctive, signaling, or triggering electrical pulse provided by the device 10 that conducts through the patient's tissue and is detectable by the separate medical device 50. In another example, wireless communication may use a communication interface (e.g., an antenna) of the device 10 to provide electromagnetic radiation that propagates through patient's tissue and is detectable, for example, using a communication interface (e.g., an antenna) of the separate medical device 50.
The housing 30 may be described as extending between a distal end region 32 and a proximal end region 34 in a generally cylindrical shape to facilitate catheter delivery. In other embodiments, the housing 30 may be prismatic or any other shape so as to perform the functionality and utility described herein. The housing 30 may include a delivery tool interface member 26, e.g., at the proximal end 34, for engaging with a delivery tool during implantation of the device 10.
All or a portion of the housing 30 may function as an electrode during cardiac therapy, for example, in sensing and/or pacing. In the example shown, the housing-based electrode 24 is shown to circumscribe a proximal portion of the housing 30. When the housing 30 is formed from an electrically conductive material, such as a titanium alloy or other examples listed above, portions of the housing 30 may be electrically insulated by a non-conductive material, such as a coating of parylene, polyurethane, silicone, epoxy, or other biocompatible polymer, leaving one or more discrete areas of conductive material exposed to define the proximal housing-based electrode 24. When the housing 30 is formed from a non-conductive material, such as a ceramic, glass or polymer material, an electrically-conductive coating or layer, such as a titanium, platinum, stainless steel, or alloys thereof, may be applied to one or more discrete areas of the housing 30 to form the proximal housing-based electrode 24. In other examples, the proximal housing-based electrode 24 may be a component, such as a ring electrode, that is mounted or assembled onto the housing 30. The proximal housing-based electrode 24 may be electrically coupled to internal circuitry of the device 10, e.g., via the electrically-conductive housing 30 or an electrical conductor when the housing 30 is a non-conductive material.
In the example shown, the proximal housing-based electrode 24 is located nearer to the housing proximal end region 34 than the housing distal end region 32 and is therefore referred to as a “proximal housing-based electrode” 24. In other examples, however, the housing-based electrode 24 may be located at other positions along the housing 30, e.g., relatively more distally than the position shown.
At the distal end region 32, the device 10 may include a distal fixation and electrode assembly 36, which may include one or more fixation members 20, in addition to one or more dart electrodes 12 of equal or unequal length. The dart electrode 12 may include a shaft 40 extending distally away from the housing distal end region 32 and may include one or more electrode elements, such as a tip electrode 42 at or near the free, distal end region of the shaft 40. The tip electrode 42 may have a conical or hemi-spherical distal tip with a relatively narrow tip diameter (e.g., less than about 1 mm) for penetrating into and through tissue layers without using a sharpened tip or needle-like tip having sharpened or beveled edges.
The shaft 40 of the dart electrode 12 may be a normally straight member and may be rigid. In other embodiments, the shaft 40 may be described as being relatively stiff but still possessing limited flexibility in lateral directions. Further, the shaft 40 may be non-rigid to allow some lateral flexing with heart motion. However, in a relaxed state, when not subjected to any external forces, the shaft 40 may maintain a straight position as shown to hold the tip electrode 42 spaced apart from the housing distal end region 32 at least by the height 47 of the shaft 40. The dart electrode 12 may be configured to pierce through one or more tissue layers to position the tip electrode 42 within a desired tissue layer, e.g., the ventricular myocardium. As such, the height 47 of the shaft 40 may correspond to the expected pacing site depth, and the shaft may have a relatively high compressive strength along its longitudinal axis to resist bending in a lateral or radial direction when pressed against the implant region 4. If a second dart electrode 12 is employed, its length may be unequal to the expected pacing site depth and may be configured to act as an indifferent electrode for delivering of pacing energy to the tissue. A longitudinal axial force may be applied against the tip electrode 42, e.g., by applying longitudinal pushing force to the proximal end 34 of the housing 30, to advance the dart electrode 12 into the tissue within target implant region. The shaft 40 may be longitudinally non-compressive. The shaft 40 may be elastically deformable in lateral or radial directions when subjected to lateral or radial forces to allow temporary flexing, e.g., with tissue motion, but may return to its normally straight position when lateral forces diminish. When the shaft 40 is not exposed to any external force, or to only a force along its longitudinal central axis, the shaft 40 may retain a straight, linear position as shown.
The one or more fixation members 20 may be described as one or more “tines” having a normally curved position. The tines may be held in a distally extended position within a delivery tool. The distal tips of tines may penetrate the heart tissue to a limited depth before elastically curving back proximally into the normally curved position (shown) upon release from the delivery tool. Further, the fixation members 20 may include one or more aspects described in, for example, U.S. Pat. No. 9,675,579 (Grubac et al.), issued 13 Jun. 2017, and U.S. Pat. No. 9,119,959 (Rys et al.), issued 1 Sep. 2015, each of which is incorporated herein by reference in its entirety.
In some examples, the distal fixation and electrode assembly 36 includes a distal housing-based electrode 22. In the case of using the device 10 as a pacemaker for multiple chamber pacing (e.g., dual or triple chamber pacing) and sensing, the tip electrode 42 may be used as a cathode electrode paired with the proximal housing-based electrode 24 serving as a return anode electrode. Alternatively, the distal housing-based electrode 22 may serve as a return anode electrode paired with tip electrode 42 for sensing ventricular signals and delivering ventricular pacing pulses. In other examples, the distal housing-based electrode 22 may be a cathode electrode for sensing atrial signals and delivering pacing pulses to the atrial myocardium in the target implant region 4. When the distal housing-based electrode 22 serves as an atrial cathode electrode, the proximal housing-based electrode 24 may serve as the return anode paired with the tip electrode 42 for ventricular pacing and sensing and as the return anode paired with the distal housing-based electrode 22 for atrial pacing and sensing.
As shown in this illustration, the target implant region 4 in some pacing applications is along the atrial endocardium 18, generally inferior to the AV node 15 and the His bundle 5. The dart electrode 42 may define the height 47 of the shaft 40 for penetrating through the atrial endocardium 18 in the target implant region 4, through the central fibrous body 16, and into the ventricular myocardium 14 without perforating through the ventricular endocardial surface 17. When the height 47 of the dart electrode 12 is fully advanced into the target implant region 4, the tip electrode 42 may rest within the ventricular myocardium 14, and the distal housing-based electrode 22 may be positioned in intimate contact with or close proximity to the atrial endocardium 18. The dart electrode 12 may have a total combined height 47 of tip electrode 42 and shaft 40 from about 3 mm to about 8 mm in various examples. The diameter of the shaft 40 may be less than about 2 mm, and may be about 1 mm or less, or even about 0.6 mm or less.
The device 10 may include a motion detector 11 within the housing 30. The motion detector 11 may be used to monitor mechanical activity, such as atrial mechanical activity (e.g., an atrial contraction) and/or ventricular mechanical activity (e.g., a ventricular contraction). In some embodiments, the motion detector 11 may be used to detect right atrial mechanical activity. A non-limiting example of a motion detector 11 includes an accelerometer. In some embodiments, the mechanical activity detected by the motion detector 11 may be used to supplement or replace electrical activity detected by one or more of the electrodes of the device 10. For example, the motion detector 11 may be used in addition to, or as an alternative to, the proximal housing-based electrode 24.
The motion detector 11 may also be used for rate response detection or to provide a rate-responsive IMD. Various techniques related to rate response may be described in U.S. Pat. No. 5,154,170 (Bennett et al.), issued Oct. 13, 1992, entitled “Optimization for rate responsive cardiac pacemaker,” and U.S. Pat. No. 5,562,711 (Yerich et al.), issued Oct. 8, 1996, entitled “Method and apparatus for rate-responsive cardiac pacing,” each of which is incorporated herein by reference in its entirety.
The distal housing-based electrode 22 may include a ring formed of an electrically conductive material, such as titanium, platinum, iridium, or alloys thereof. The distal housing-based electrode 22 may be a single, continuous ring electrode. In other examples, portions of the ring may be coated with an electrically insulating coating, e.g., parylene, polyurethane, silicone, epoxy, or other insulating coating, to reduce the electrically conductive surface area of the ring electrode. For instance, one or more sectors of the ring may be coated to separate two or more electrically conductive exposed surface areas of the distal housing-based electrode 22. Reducing the electrically conductive surface area of the distal housing-based electrode 22, e.g., by covering portions of the electrically conductive ring with an insulating coating, may increase the electrical impedance of the distal housing-based 22, and thereby, reduce the current delivered during a pacing pulse that captures the myocardium, e.g., the atrial myocardial tissue. A lower current drain may conserve the power source, e.g., one or more rechargeable or non-rechargeable batteries, of the device 10.
As described above, the distal housing-based electrode 22 may be configured as an atrial cathode electrode for delivering pacing pulses to the atrial tissue at the implant site in combination with the proximal housing-based electrode 24 as the return anode. The electrodes 22 and 24 may be used to sense atrial P-waves for use in controlling atrial pacing pulses (delivered in the absence of a sensed P-wave) and for controlling atrial-synchronized ventricular pacing pulses delivered using the tip electrode 42 as a cathode and the proximal housing-based electrode 24 as the return anode. In other examples, the distal housing-based electrode 22 may be used as a return anode in conjunction with the cathode tip electrode 42 for ventricular pacing and sensing.
The power source 98 may provide power to the circuitry of the device 10 including each of the components 80, 82, 84, 86, 88, and 90 as needed. The power source 98 may include one or more energy storage devices, such as one or more rechargeable or non-rechargeable batteries. The connections between the power source 98 and each of the components 80, 82, 84, 86, 88, and 90 are to be understood from the general block diagram illustrated but are not shown for the sake of clarity. For example, the power source 98 may be coupled to one or more charging circuits included in the therapy delivery circuit 84 for providing the power needed to charge holding capacitors included in the therapy delivery circuit 84 that are discharged at appropriate times under the control of the control circuit 80 for delivering pacing pulses, e.g., according to a dual chamber pacing mode such as DDI(R). The power source 98 may also be coupled to components of the sensing circuit 86, such as sense amplifiers, analog-to-digital converters, switching circuitry, etc., sensors 90, the telemetry circuit 88, and the memory 82 to provide power to the various circuits.
Any suitable technique may be used to recharge a rechargeable power source 98. In some embodiments, the device 10 may include an antenna, inductive coils, or other inductive coupling structures configured to couple to another device, such as an external charger or programmer, to receive power in situ. Various examples of charging a leadless implantable medical device are described in U.S. Patent Pub. No. 2018/0212451 (Schmidt et al.), filed Jan. 26, 2017, entitled “Recharge of Implanted Medical Devices,” which is incorporated herein by reference in its entirety. The device 10 may also be configured to use various techniques to extend the life of the power source 98, such as a low-power mode.
Various examples of power sources and techniques related to power sources may be used, such as those found in, for example, U.S. Pat. No. 8,383,269 (Scott et al.), granted Feb. 26, 2013, U.S. Pat. No. 8,105,714 (Schmidt et al.), granted Jan. 31, 2012, and U.S. Pat. No. 7,635,541 (Scott et al.), granted Dec. 22, 2009, each of which is incorporated herein by reference in its entirety.
The functional blocks shown represent functionality included in the device 10 and may include any discrete and/or integrated electronic circuit components that implement analog, and/or digital circuits capable of producing the functions attributed to the medical device 10 herein. The various components may include processing circuitry, such as an application specific integrated circuit (ASIC), an electronic circuit, a processor (shared, dedicated, or group), and memory that execute one or more software or firmware programs, a combinational logic circuit, state machine, or other suitable components or combinations of components that provide the described functionality. The particular form of software, hardware, and/or firmware employed to implement the functionality disclosed herein will be determined primarily by the particular system architecture employed in the medical device and by the particular detection and therapy delivery methodologies employed by the medical device. Providing software, hardware, and/or firmware to accomplish the described functionality in the context of any modern cardiac medical device system, given the disclosure herein, is within the abilities of one of skill in the art.
The memory 82 may include any volatile, non-volatile, magnetic, or electrical non-transitory computer readable storage media, such as random-access memory (RAM), read-only memory (ROM), non-volatile RAM (NVRAM), electrically-erasable programmable ROM (EEPROM), flash memory, or any other memory device. Furthermore, the memory 82 may include a non-transitory computer readable media storing instructions that, when executed by one or more processing circuits, cause the control circuit 80 and/or other processing circuitry to perform a single, dual, or triple chamber pacing (e.g., single or multiple chamber pacing) function or other sensing and therapy delivery functions attributed to the device 10. The non-transitory computer-readable media storing the instructions may include any of the media listed above.
The control circuit 80 may communicate, e.g., via a data bus, with the therapy delivery circuit 84 and the sensing circuit 86 for sensing cardiac electrical signals and controlling delivery of cardiac electrical stimulation therapies in response to sensed cardiac events, e.g., P-waves and R-waves, or the absence thereof. The tip electrode 42, the distal housing-based electrode 22, and the proximal housing-based electrode 24 may be electrically coupled to the therapy delivery circuit 84 for delivering electrical stimulation pulses to the patient's heart and to the sensing circuit 86 and for sensing cardiac electrical signals.
The sensing circuit 86 may include an atrial (A) sensing channel 87 and a ventricular (V) sensing channel 89. The distal housing-based electrode 22 and the proximal housing-based electrode 24 may be coupled to the atrial sensing channel 87 for sensing atrial signals, e.g., P-waves attendant to the depolarization of the atrial myocardium. In examples that include two or more selectable distal housing-based electrodes, the sensing circuit 86 may include switching circuitry for selectively coupling one or more of the available distal housing-based electrodes to cardiac event detection circuitry included in the atrial sensing channel 87. Switching circuitry may include a switch array, switch matrix, multiplexer, or any other type of switching device suitable to selectively couple components of the sensing circuit 86 to selected electrodes. The tip electrode 42 and the proximal housing-based electrode 24 may be coupled to the ventricular sensing channel 89 for sensing ventricular signals, e.g., R-waves attendant to the depolarization of the ventricular myocardium.
Each of the atrial sensing channel 87 and the ventricular sensing channel 89 may include cardiac event detection circuitry for detecting P-waves and R-waves, respectively, from the cardiac electrical signals received by the respective sensing channels. The cardiac event detection circuitry included in each of the channels 87 and 89 may be configured to amplify, filter, digitize, and rectify the cardiac electrical signal received from the selected electrodes to improve the signal quality for detecting cardiac electrical events. The cardiac event detection circuitry within each channel 87 and 89 may include one or more sense amplifiers, filters, rectifiers, threshold detectors, comparators, analog-to-digital converters (ADCs), timers, or other analog or digital components. A cardiac event sensing threshold, e.g., a P-wave sensing threshold and an R-wave sensing threshold, may be automatically adjusted by each respective sensing channel 87 and 89 under the control of the control circuit 80, e.g., based on timing intervals and sensing threshold values determined by the control circuit 80, stored in the memory 82, and/or controlled by hardware, firmware, and/or software of the control circuit 80 and/or the sensing circuit 86.
Upon detecting a cardiac electrical event based on a sensing threshold crossing, the sensing circuit 86 may produce a sensed event signal that is passed to the control circuit 80. For example, the atrial sensing channel 87 may produce a P-wave sensed event signal in response to a P-wave sensing threshold crossing. The ventricular sensing channel 89 may produce an R-wave sensed event signal in response to an R-wave sensing threshold crossing. The sensed event signals may be used by the control circuit 80 for setting pacing escape interval timers that control the basic time intervals used for scheduling cardiac pacing pulses. A sensed event signal may trigger or inhibit a pacing pulse depending on the particular programmed pacing mode. For example, a P-wave sensed event signal received from the atrial sensing channel 87 may cause the control circuit 80 to inhibit a scheduled atrial pacing pulse and schedule a ventricular pacing pulse at a programmed atrioventricular (AV) pacing interval. If an R-wave is sensed before the AV pacing interval expires, the ventricular pacing pulse may be inhibited. If the AV pacing interval expires before the control circuit 80 receives an R-wave sensed event signal from the ventricular sensing channel 89, the control circuit 80 may use the therapy delivery circuit 84 to deliver the scheduled ventricular pacing pulse synchronized to the sensed P-wave.
In some examples, the device 10 may be configured to deliver a variety of pacing therapies including bradycardia pacing, cardiac resynchronization therapy, post-shock pacing, and/or tachycardia-related therapy, such as ATP, among others. For example, the device 10 may be configured to detect non-sinus tachycardia and deliver ATP. The control circuit 80 may determine cardiac event time intervals, e.g., PP intervals between consecutive P-wave sensed event signals received from the atrial sensing channel 87, RR intervals between consecutive R-wave sensed event signals received from the ventricular sensing channel 89, and P-R and/or R-P intervals received between P-wave sensed event signals and R-wave sensed event signals. These intervals may be compared to tachycardia detection intervals for detecting non-sinus tachycardia. Tachycardia may be detected in a given heart chamber based on a threshold number of tachycardia detection intervals being detected.
The therapy delivery circuit 84 may include atrial pacing circuit 83 and ventricular pacing circuit 85. Each pacing circuit 83 and 85 may include charging circuitry, one or more charge storage devices such as one or more low voltage holding capacitors, an output capacitor, and/or switching circuitry that controls when the holding capacitor(s) are charged and discharged across the output capacitor to deliver a pacing pulse to the pacing electrode vector coupled to respective pacing circuits 83 or 85. The tip electrode 42 and the proximal housing-based electrode 24 may be coupled to the ventricular pacing circuit 85 as a bipolar cathode and anode pair for delivering ventricular pacing pulses, e.g., upon expiration of an AV or VV pacing interval set by the control circuit 80 for providing atrial-synchronized ventricular pacing and a basic lower ventricular pacing rate.
The atrial pacing circuit 83 may be coupled to the distal housing-based electrode 22 and the proximal housing-based electrode 24 to deliver atrial pacing pulses. The control circuit 80 may set atrial pacing intervals according to a programmed lower pacing rate or a temporary lower rate set according to a rate-responsive sensor indicated pacing rate. Atrial pacing circuit may be controlled to deliver an atrial pacing pulse if the atrial pacing interval expires before a P-wave sensed event signal is received from the atrial sensing channel 87. The control circuit 80 starts an AV pacing interval in response to a delivered atrial pacing pulse to provide synchronized multiple chamber pacing (e.g., dual or triple chamber pacing).
Charging of a holding capacitor of the atrial or ventricular pacing circuit 83 or 85 to a programmed pacing voltage amplitude and discharging of the capacitor for a programmed pacing pulse width may be performed by the therapy delivery circuit 84 according to control signals received from the control circuit 80. For example, a pace timing circuit included in the control circuit 80 may include programmable digital counters set by a microprocessor of the control circuit 80 for controlling the basic pacing time intervals associated with various single chamber or multiple chamber pacing (e.g., dual or triple chamber pacing) modes or anti-tachycardia pacing sequences. The microprocessor of the control circuit 80 may also set the amplitude, pulse width, polarity, or other characteristics of the cardiac pacing pulses, which may be based on programmed values stored in the memory 82.
The device 10 may include other sensors 90 for sensing signals from the patient for use in determining a need for and/or controlling electrical stimulation therapies delivered by the therapy delivery circuit 84. In some examples, a sensor indicative of a need for increased cardiac output may include a patient activity sensor, such as an accelerometer. An increase in the metabolic demand of the patient due to increased activity as indicated by the patient activity sensor may be determined by the control circuit 80 for use in determining a sensor-indicated pacing rate.
Control parameters utilized by the control circuit 80 for sensing cardiac events and controlling pacing therapy delivery may be programmed into the memory 82 via the telemetry circuit 88, which may also be described as a communication interface. The telemetry circuit 88 includes a transceiver and antenna for communicating with an external device such as a programmer or home monitor, using radio frequency communication or other communication protocols. The control circuit 80 may use the telemetry circuit 88 to receive downlink telemetry from and send uplink telemetry to the external device. In some cases, the telemetry circuit 88 may be used to transmit and receive communication signals to/from another medical device implanted in the patient.
A distal fixation and electrode assembly 736 may be coupled to the housing distal end region 732. The distal fixation and electrode assembly 736 may include an electrically insulative distal member 772 coupled to the housing distal end region 732. The tissue piercing electrode 712 extends away from the housing distal end region 732, and multiple non-tissue piercing electrodes 722 may be coupled directly to the insulative distal member 772. The tissue piercing electrode 712 extends in a longitudinal direction away from the housing distal end region 732 and may be coaxial with the longitudinal center axis 731 of the housing 730.
The tissue piercing distal electrode 712 may include an electrically insulated shaft 740 and a tip electrode 742. In some examples, the tissue piercing distal electrode 712 is an active fixation member including a helical shaft 740 and a distal cathode tip electrode 742. The helical shaft 740 may extend from a shaft distal end region 743 to a shaft proximal end region 741, which may be directly coupled to the insulative distal member 772. The helical shaft 740 may be coated with an electrically insulating material, e.g., parylene or other examples listed herein, to avoid sensing or stimulation of cardiac tissue along the shaft length. The tip electrode 742 is at the shaft distal end region 743 and may serve as a cathode electrode for delivering ventricular pacing pulses and sensing ventricular electrical signals using the proximal housing-based electrode 724 as a return anode when the tip electrode 742 is advanced into ventricular tissue. The proximal housing-based electrode 724 may be a ring electrode circumscribing the housing 730 and may be defined by an uninsulated portion of the longitudinal sidewall 735. Other portions of the housing 730 not serving as an electrode may be coated with an electrically insulating material as described above in conjunction with
Using two or more tissue-piercing electrodes (e.g., of any type) penetrating into the LV myocardium may be used for more localized pacing capture and may mitigate ventricular pacing spikes affecting capturing atrial tissue. In some embodiments, multiple tissue-piercing electrodes may include two or more of a dart-type electrode (e.g., electrode 12 of
In some embodiments, one or more tissue-piercing electrodes (e.g., of any type) that penetrate into the LV myocardium may be a multi-polar tissue-piercing electrode. A multi-polar tissue-piercing electrode may include one or more electrically active and electrically separate elements, which may enable bipolar or multi-polar pacing from one or more tissue-piercing electrodes.
Multiple non-tissue piercing electrodes 722 may be provided along a periphery of the insulative distal member 772, peripheral to the tissue piercing electrode 712. The insulative distal member 772 may define a distal-facing surface 738 of the device 710 and a circumferential surface 739 that circumscribes the device 710 adjacent to the housing longitudinal sidewall 735. Non-tissue piercing electrodes 722 may be formed of an electrically conductive material, such as titanium, platinum, iridium, or alloys thereof. In the illustrated embodiment, six non-tissue piercing electrodes 722 are spaced apart radially at equal distances along the outer periphery of insulative distal member 772, however, two or more non-tissue piercing electrodes 722 may be provided.
Non-tissue piercing electrodes 722 may be discrete components each retained within a respective recess 774 in the insulative member 772 sized and shaped to mate with the non-tissue piercing electrode 722. In other examples, the non-tissue piercing electrodes 722 may each be an uninsulated, exposed portion of a unitary member mounted within or on the insulative distal member 772. Intervening portions of the unitary member not functioning as an electrode may be insulated by the insulative distal member 772 or, if exposed to the surrounding environment, may be coated with an electrically insulating coating, e.g., parylene, polyurethane, silicone, epoxy, or other insulating coating.
When the tissue piercing electrode 712 is advanced into cardiac tissue, at least one non-tissue piercing electrode 722 may be positioned against, in intimate contact with, or in operative proximity to, a cardiac tissue surface for delivering pulses and/or sensing cardiac electrical signals produced by the patient's heart. For example, non-tissue piercing electrodes 722 may be positioned in contact with right atrial endocardial tissue for pacing and sensing in the atrium when the tissue piercing electrode 712 is advanced into the atrial tissue and through the central fibrous body until the distal tip electrode 742 is positioned in direct contact with ventricular tissue, e.g., ventricular myocardium and/or a portion of the ventricular conduction system.
Non-tissue piercing electrodes 722 may be coupled to the therapy delivery circuit 84 and the sensing circuit 86 (see
Certain non-tissue piercing electrodes 722 selected for atrial pacing and/or atrial sensing may be selected based on atrial capture threshold tests, electrode impedance, P-wave signal strength in the cardiac electrical signal, or other factors. For example, a single one or any combination of two or more individual non-tissue piercing electrodes 722 functioning as a cathode electrode that provides an optimal combination of a low pacing capture threshold amplitude and relatively high electrode impedance may be selected to achieve reliable atrial pacing using minimal current drain from the power source 98.
In some instances, the distal-facing surface 738 may uniformly contact the atrial endocardial surface when the tissue piercing electrode 712 anchors the housing 730 at the implant site. In that case, all the electrodes 722 may be selected together to form the atrial cathode. Alternatively, every other one of the electrodes 722 may be selected together to form a multi-point atrial cathode having a higher electrical impedance that is still uniformly distributed along the distal-facing surface 738. Alternatively, a subset of one or more electrodes 722 along one side of the insulative distal member 772 may be selected to provide pacing at a desired site that achieves the lowest pacing capture threshold due to the relative location of the electrodes 722 to the atrial tissue being paced.
In other instances, the distal-facing surface 738 may be oriented at an angle relative to the adjacent endocardial surface depending on the positioning and orientation at which the tissue piercing electrode 712 enters the cardiac tissue. In this situation, one or more of the non-tissue piercing electrodes 722 may be positioned in closer contact with the adjacent endocardial tissue than other non-tissue piercing electrodes 722, which may be angled away from the endocardial surface. By providing multiple non-tissue piercing electrodes along the periphery of the insulative distal member 772, the angle of the tissue piercing electrode 712 and the housing distal end region 732 relative to the cardiac surface, e.g., the right atrial endocardial surface, may not be required to be substantially parallel. Anatomical and positional differences may cause the distal-facing surface 738 to be angled or oblique to the endocardial surface, however, multiple non-tissue piercing electrodes 722 distributed along the periphery of the insulative distal member 772 increase the likelihood of good contact between one or more electrodes 722 and the adjacent cardiac tissue to promote acceptable pacing thresholds and reliable cardiac event sensing using at least a subset of multiple electrodes 722. Contact or fixation circumferentially along the entire periphery of the insulative distal member 772 may not be required.
The non-tissue piercing electrodes 722 are shown to each include a first portion 722a extending along the distal-facing surface 738 and a second portion 722b extending along the circumferential surface 739. The first portion 722a and the second portion 722b may be continuous exposed surfaces such that the active electrode surface wraps around a peripheral edge 776 of the insulative distal member 772 that joins the distal facing surface 738 and the circumferential surface 739. The non-tissue piercing electrodes 722 may include one or more of the electrodes 772 along the distal-facing surface 738, one or more electrodes along the circumferential surface 739, one or more electrodes each extending along both of the distal-facing surface 738 and the circumferential surface 739, or any combination thereof. The exposed surface of each of the non-tissue piercing electrodes 722 may be flush with respective distal-facing surfaces 738 and/or circumferential surfaces. In other examples, each of the non-tissue piercing electrodes 722 may have a raised surface that protrudes from the insulative distal member 772. Any raised surface of the electrodes 722, however, may define a smooth or rounded, non-tissue piercing surface.
The distal fixation and electrode assembly 736 may seal the distal end region of the housing 730 and may provide a foundation on which the electrodes 722 are mounted. The electrodes 722 may be referred to as housing-based electrodes. The electrodes 722 may not be not carried by a shaft or other extension that extends the active electrode portion away from the housing 730, like the distal tip electrode 742 residing at the distal tip of the helical shaft 740 extending away from the housing 730. Other examples of non-tissue piercing electrodes presented herein that are coupled to a distal-facing surface and/or a circumferential surface of an insulative distal member include the distal housing-based ring electrode 22 (
The non-tissue piercing electrodes 722 and other examples listed above are expected to provide more reliable and effective atrial pacing and sensing than a tissue piercing electrode provided along the distal fixation and electrode assembly 736. The atrial chamber walls are relatively thin compared to ventricular chamber walls. A tissue piercing atrial cathode electrode may extend too deep within the atrial tissue leading to inadvertent sustained or intermittent capture of ventricular tissue. A tissue piercing atrial cathode electrode may lead to interference with sensing atrial signals due to ventricular signals having a larger signal strength in the cardiac electrical signal received via tissue-piercing atrial cathode electrodes that are in closer physical proximity to the ventricular tissue. The tissue piercing electrode 712 may be securely anchored into ventricular tissue for stabilizing the implant position of the device 710 and providing reasonable certainty that the tip electrode 742 is sensing and pacing in ventricular tissue while the non-tissue piercing electrodes 722 are reliably pacing and sensing in the atrium. When the device 710 is implanted in the target implant region 4, e.g., as shown in
The method 100 may include process 102, in which activity of the right atrium is monitored. The medical device may use one or more of a plurality of electrodes to monitor the electrical activity of the patient's heart. For example, when implanted, a right atrial electrode (e.g., proximal housing-based electrode 24 or distal housing-based electrode 22 of
In addition, or as an alternative, to using the right atrial electrode, the medical device may use a motion detector to monitor the mechanical activity of the patient's heart. For example, when implanted, a right atrial motion detector may be positioned to sense mechanical activity of the right atrium. In some embodiments, the right atrial motion detector may be positioned within the implantable medical device 10. In some embodiments, the right atrial motion detector may be wirelessly coupled, or coupled using a lead, to the implantable medical device 10. The motion detector may be coupled to the same or a different sensing circuit as the electrodes.
The method 100 may further include process 104, in which pacing therapy is delivered to the ventricle. For example, in process 104, pacing therapy may be delivered to the left ventricle, right ventricle, ventricular septum (e.g., higher posterior basal septum region), or other parts of the ventricular myocardium, in response to the monitored activity of the right atrium in process 102. The monitored activity may include electrical activity, mechanical activity, or both electrical and mechanical activity (e.g., using a right atrial electrode and/or a right atrial motion detector). The medical device may use one or more of the plurality of electrodes to deliver cardiac therapy to the patient's heart. For example, when implanted, a tissue-piercing electrode (e.g., tip electrode 42) may be positioned in the ventricular septum to deliver cardiac therapy to the left ventricle of the patient's heart. The tissue-piercing electrode may be leadlessly coupled to the housing. In some embodiments, the tissue-piercing electrode may be used to sense electrical activity of the left ventricle. The tissue-piercing electrode may extend from a distal end region of the housing.
As mentioned above, the method 100 may be used with cardiac resynchronization pacing (e.g., cardiac resynchronization therapy). In some embodiments using cardiac resynchronization pacing, a pace may be delivered to one or both ventricles in response to a sensed atrial or ventricular event. Examples of cardiac resynchronization pacing include biventricular pacing and monoventricular pacing. Monoventricular pacing may include left ventricular pacing, right ventricular pacing, or fusion pacing. Various methods of performing cardiac resynchronization pacing are described in U.S. Patent Application Pub. No. 2017/0340885 (Sambelashvili), filed 31 Jul. 2017, entitled “Systems and methods for leadless cardiac resynchronization therapy,” and U.S. Pat. No. 9,789,319 (Sambelashvili), issued 17 Oct. 2017, entitled “Systems and methods for leadless cardiac resynchronization therapy,” each of which is incorporated herein by reference in its entirety.
One type of cardiac resynchronization pacing is biventricular pacing. Biventricular pacing may include pacing the right ventricle (RV) with a RV electrode and a left ventricle (LV) with a LV electrode (e.g., the tissue-piercing electrode), which are typically different electrodes. In one or more embodiments, the implantable medical device can be configured to automatically switch between biventricular pacing and fusion pacing. In general, the primary goal may be to ensure the ventricles are synchronized with each other. Monoventricular pacing, or specifically fusion pacing, may be used instead of biventricular pacing to achieve synchrony. Skilled artisans appreciate that a patient's heart may be treated using adaptive CRT in which biventricular pacing may be delivered during one period of time (e.g., 1 hour, day, week etc.) and at another time, fusion pacing may be delivered to return the ventricles to synchrony. Typically, fusion pacing involves pacing the LV. However, there may be conditions for which the RV may be solely paced.
One type of adaptive CRT is adaptive LV pacing. Adaptive LV pacing may be described as leveraging intrinsic RV conduction by pre-pacing the LV to synchronize with intrinsic RV activation. The timing of the LV pace may be automatically adjusted based on the atrial to intrinsic QRS interval measurement (AV interval). One or more embodiments can set the LV pace to occur at about 70% of the intrinsic AV interval, but at least 40 ms prior to the intrinsic QRS.
One or more other embodiments can configure LV pacing in response to, or based on, a moderately lengthened QRS. For example, if the QRS width exceeds 120 ms, but does not exceed 160 ms, then LV pacing with fusion is selected. Otherwise, if the QRS width is greater than 160 ms, then biventricular (BiV) pacing is selected. Implementing a moderately lengthened QRS threshold may benefit heart failure patients. Efficacies of LV-only pacing or biventricular pacing may be predicted by the moderately lengthened QRS duration. An illustrative moderately lengthened QRS may correspond to a QRS width in the range of 130 ms-150 ms.
Adaptive CRT may use intrinsic AV conduction to determine whether to use biventricular or fusion pacing. In one or more embodiments, the intrinsic AV conduction may be automatically evaluated. In one or more embodiments, the IMD (e.g., an ICD), leadless pacing device (LPD) (e.g., an intracardiac medical device), and/or subcutaneous implantable device (SD) may automatically evaluate intrinsic ventricular conduction based upon QRS duration from the far-field electromyograph (EGM), or right ventricular sense to left ventricular sense (RVs-LVs) interval from the IMD sensing markers is automatically evaluated by the IMD or SD. For further detail, U.S. Pat. No. 4,374,382 issued to Markowitz et al. describes IMD sensing markers, which is incorporated herein by reference in its entirety. Based on the results, fusion pacing (i.e., LV only pacing or RV only pacing) or biventricular pacing may be selected. For example, RVs-LVs interval not exceeding 150 ms could correspond to LV only pacing, whereas >150 ms could switch the algorithm to biventricular pacing. In one or more other embodiments, RVs-LVs interval not exceeding 80 ms corresponds to fusion pacing while greater than 80 ms switches to biventricular pacing. Typically, RVs-LVs are shorter than the corresponding QRS width. Therefore, it takes about 40 ms to sense the onset of QRS in the RV and the final portion of the QRS in the LV is also sensed prior to the QRS end.
Various devices may be used to carry out the functionality of adaptive CRT. In one or more other embodiments, the IMD may track the moderately lengthened QRS over time and then relies on trend data to switch between biventricular pacing and fusion pacing. For example, assume that the moderately lengthened QRS is 120 ms, 125 ms, 130 ms, 135 m, 140 ms, and 145 ms, respectively for 6 consecutive weeks. The increasing trend could trigger the switch to biventricular pacing before the threshold is met for switching to biventricular pacing.
In another embodiment, the SD could send a control signal to the LPD to initiate CRT. The LPD could sense a cardiac signal (i.e., a second electrical signal) from the heart of the patient. Based on the cardiac signal, the LPD could determine whether to deliver CRT to the heart from the LPD. For example, the LPD, based on the second electrical signal, could determine that CRT is not necessary. The LPD could consider whether sensed data meets a pre-specified threshold. For instance, if the QRS width does not exceed 120 ms, the LPD may withhold the delivery of CRT therapy (e.g., the LPD could then signal the SD that CRT should not be delivered based upon the cardiac signal). The SD can be configured to perform a more detailed analysis in which at least one or more parameters (such as at least two parameters) are evaluated. The SD could then send another command signal that confirms, denies, or overrides the LPD.
In another embodiment, the LPD could sense a cardiac signal that indicates a switch between fusion pacing to biventricular pacing should occur and would signal the SD. The SD could be configured to send an override signal to the LPD unless certain conditions are met.
In yet another embodiment, the LPD could determine that biventricular pacing is may be used instead of fusion pacing in contravention to the SD communication. In one embodiment, the LPD would deliver biventricular pacing. In one or more other embodiments, the LPD could determine that fusion pacing may be used instead of biventricular pacing in contravention to the SD communication. In this scenario, the LPD could deliver fusion pacing.
In another embodiment, the SD transmits a control signal to the LPD to initiate CRT. The LPD senses a cardiac signal (i.e., a second electrical signal) from the heart of the patient. Based on the cardiac signal, the LPD could determine whether to deliver CRT or the type of CRT to deliver to the heart from the LPD. In one or more embodiments, the LPD, based on the second electrical signal, could initially determine that CRT should not be used. The initial determination by the LPD could use tests such as a threshold of one or more parameters. In one or more embodiments, the SD could perform a more detailed analysis as to whether CRT should be delivered. Using the sensed data from the LPD and/or SD, the SD could generate another signal to the LPD that either confirms, denies or overrides the LPDs initial determination.
In another embodiment, the LPD could sense a cardiac signal that indicates a switch should occur between fusion pacing to biventricular pacing. Determining whether to switch between fusion pacing and biventricular pacing could be determined based upon one or more parameters (e.g., moderately lengthened QRS, etc.). The LPD could be configured to either automatically switch between fusion pacing and biventricular pacing or to wait until the SD confirms or denies switching between the CRT pacing mode (i.e., fusion pacing and biventricular pacing). The SD could be configured to send a confirmatory signal or a signal denying the LPD switching the pacing mode.
In yet another embodiment, the LPD could determine that biventricular pacing may be used instead of fusion pacing in contravention to the SD communication. In one embodiment, the LPD would deliver biventricular pacing. In one or more other embodiments, the LPD could determine that fusion pacing is required over biventricular pacing in contravention to the SD communication. In this scenario, the LPD could deliver fusion pacing.
In one or more other embodiments, a device having SD-like functionality is implanted into a patient's heart. For example, the SD could function as a conventional ICD or have the SD functionality described herein. Electrical signals are then sensed which includes moderately lengthened QRS duration data from the patient's heart. A determination is made as to whether cardiac resynchronization pacing therapy (CRT pacing) is appropriate based upon the moderately lengthened QRS duration in the sensed electrical signals. The CRT pacing pulses are delivered to the heart using electrodes. In one or more embodiments, the SD can switch between fusion pacing and biventricular pacing based upon data (e.g., moderately lengthened QRS, etc.) sensed from the heart.
In addition, there are even further embodiments that may be implemented with the methods described herein. One or more LPDs carrying one or more electrodes may be implanted within various chambers of the heart of the patient or otherwise in close proximity of the cardiac muscle. At these locations, an LPD may sense ECG signals with high signal-to-noise ratios to detect arrhythmias. In addition, an LPD may provide cardiac pacing at the location of the implanted LPD. In some examples, one or both of SD and LPD may share detected signals or physiological information (e.g., R-R intervals, electrogram morphology measurements, and/or electrocardiograms or electrograms) such that the device receiving such information can determine a condition of patient (e.g., determine whether or not patient is experiencing an arrhythmia and or lack of synchrony between ventricles). Communication between an LPD and a subcutaneous ICD (SICD) is described in U.S. patent application Ser. No. 13/756,085, filed on Jan. 31, 2013, which is incorporated herein by reference in its entirety.
In some examples, communication between the SICD and an LPD may be used to initiate therapy and/or confirm that therapy should be delivered. The SICD may also transmit a communication message to the LPD instructing the LPD to change one or more parameters that define the CRT therapy. In this one-way communication example, the SICD may be configured to transmit communications to the LPD and the LPD may be configured to receive the communication from the SICD. Alternatively, one-way communication may be established such that the LPD may be configured to transmit communications to the SICD (e.g., communication from an LPD). In other examples, two-way communication may allow confirmation of a detected of a cardiac condition (e.g., ventricular dyssynchrony, tachyarrhythmia, bradycardia, etc.) prior to delivery of any therapy. Communication between the SD and the LPD is described in greater details in U.S. patent application Ser. No. 13/756,085 filed May 26, 2013 and entitled “Systems and methods for leadless pacing and shock therapy,” which is incorporated herein by reference in its entirety.
One or more of the embodiments described herein may utilize far-field sensing to carry out cardiac resynchronization pacing. In some embodiments, one or more of the electrodes of a device may be used for far-field sensing of electrical activity in a different chamber. For example, a right atrial electrode or a tissue-piercing electrode may be used to monitor far-field electrical activity of the right ventricle. The far-field sensing may be particularly useful in cardiac resynchronization pacing as described above. Ascertaining RV timing may be used to tailor the timing of the LV pace for an individual patient to allow for fusion pacing (e.g., fusing RV and LV activation).
The method 110 may include process 112, in which an atrial event is sensed. For example, the atrial event may be a right atrial event in monitored activity of the right atrium, e.g., as mentioned in process 102. The right atrial electrode may be used to sense the right atrial event within monitored electrical activity of the right atrium. In addition, or alternatively, the right atrial motion detector may be used to sense the right atrial event within monitored mechanical activity of the right atrium. The atrial event may be determined by the controller of the medical device using the sensing circuit.
The method 110 may further include process 114, which includes waiting for a selected A-V time period to elapse in response to the detection of the atrial event in process 112. For example, the controller of the medical device may wait the selected A-V time period after detecting the atrial event.
The method 110 may further include process 116, in which a ventricular pace is delivered in response to the atrial event after the selected A-V time period has elapsed in process 114. In some embodiments, process 116 may be performed without process 114. It is contemplated that the ventricular pace may be delivered in response to sensing the atrial event without using the selected A-V time period.
In some embodiments, the A-V time period is configured to synchronize an atrial event and a ventricular event for atrioventricular synchrony. The A-V time period may also be configured to, or modified to, improve cardiac resynchronization. For example, the A-V time period may be used to pace one or both ventricles for ventricular synchrony (e.g., using biventricular pacing or monoventricular pacing, such as fusion pacing) described herein in more detail below.
The method 120 may include process 122, in which an atrial event is sensed within the monitored activity from process 102 (
The method 120 may further include process 124, in which activity of the left ventricle is monitored. One or more tissue-piercing electrodes may be used to sense the activity of the left ventricle. If more than one tissue-piercing electrode has contact with LV myocardium, the tissue-piercing electrodes can be used to both sense and pace the LV.
The method 120 may further include process 126, which starts an A-V time period. The method 120 may further include process 128, which determines whether a ventricular event is sensed in response to the monitored activities in processes 122 and 124. In particular, the process 128 may determine whether a ventricular event is sensed before the A-V time period elapses. The controller of the medical device may be used to make the determination. If a ventricular event is not sensed in process 128, the method 120 may branch to process 130. If a ventricular event is sensed, the method 120 may branch to process 132.
The method 120 may further include process 130, in which a ventricular pace is delivered after the selected A-V time period has elapsed. Process 130 may be the same or similar to process 114 of method 110 (
The method 120 may further include process 132, which withholds delivering the ventricular pace. Withholding the ventricular pace delivery may be described as inhibiting pacing therapy.
The method 140 may include process 142, in which activity of the right atrium is monitored. When implanted, the controller of the medical device may use the sensing circuit and right atrial electrode or right atrial motion detector to monitor the activity of the right atrium.
The method 140 may further include process 144, in which activity of the left ventricle is monitored. When implanted, the controller of the medical device may use the sensing circuit and tissue-piercing electrode, or a left ventricular motion detector, to monitor the activity of the left ventricle.
The method 140 may further include process 146, in which tachycardia is determined based on the monitored activities in processes 142 and 144. The controller may be used to make the determination.
The method 150 may include process 152, which determines whether a tachycardia rhythm has a 1:1 AV conduction rhythm or signature. As used herein, a 1:1 AV conduction or rhythm refers to every V-event being preceded by an A-event with a degree of regularity in terms of the A-V interval. The controller of the medical device may be used to make the determination. If a 1:1 AV conduction rhythm is determined, the method 150 may continue to process 154. If a 1:1 AV conduction rhythm is not determined by process 152, then the method 150 may continue to process 156.
The method 150 may further include process 154, in which therapy is withheld. For example, the controller may be used to withhold tachycardia-related therapy in response to determining that the detected rhythm is non-treatable.
The method 150 may further include process 156 (e.g., in response to not determining a 1:1 AV conduction rhythm in process 152), in which a type of tachycardia therapy to deliver is determined. For example, a determination may be made that the V-rate is faster than a rate threshold (e.g., 200 bpm) for ventricular fibrillation, in which case the device may initiate shock therapy in process 160. If not, then the device may initiate anti-tachycardia pacing therapy in process 158.
The method 170 may include process 172, which performs a V-V event interval analysis, which includes determination of parameters like median, range, mode-sum, or other metrics reflective of how fast a tachycardia rhythm is and how regular is the interval between successive V-events. The method 170 may further include process 174, which performs electrogram morphology analysis. This may include comparing entire morphology or gross morphologic features of different V-events within a tachycardia rhythm and determining a morphologic similarity index. Details of determining morphologic and rate regularity of tachycardia events may be described in U.S. Pat. No. 8,594,775 (Ghosh et al.), which is incorporated herein by reference in its entirety.
The method 170 may further include process 176, in which rate and rhythm regularity of tachycardia events are determined based on combination of monitoring of intervals between successive V events (process 172) and corresponding electrogram morphologies (process 174). In some embodiments, a monomorphic VT may be determined based on regularity of the successive V-events and/or similarity of electrogram morphologies corresponding to the V-events, whereas a polymorphic rhythm may be determined if both rate regularity and morphology similarity criteria are not met.
Non-limiting examples of tachycardia therapy that may be delivered include anti-tachycardia pacing and shock therapy (e.g., defibrillation therapy). In some embodiments, if a monomorphic VT is determined, the device may initiate anti-tachycardia pacing (ATP). If a polymorphic rhythm is determined the device may initiate shock therapy by signaling the external device to deliver a shock.
Examples of tachycardia therapy determination methods, including interval analyses and electrogram morphology analyses, that may be used with the methods of the present disclosure may be described in U.S. Pat. No. 7,031,711 (Brown et al.), issued 18 Apr. 2016, and U.S. Pat. No. 8,594,775 (Ghosh et al.), issued 26 Nov. 2013, and U.S. Pat. No. 8,750,994 (Ghosh et al.), issued 10 Jun. 2014, each of which is incorporated herein by reference in its entirety.
The method 190 may include process 192, which determines that tachycardia is present. For example, the controller of the medical device may determine that tachycardia is present based on monitored activities generated using the plurality of electrodes and/or one or more motion detectors. Process 192 may be the same or similar to process 146 of
The method 190 may further include process 194, which delivers tachycardia-related therapy using the medical device and/or separate medical device based on the determination that tachycardia is present in process 192. For example, the medical device may use one or more of the plurality of electrodes to provide anti-tachycardia pacing.
In some embodiments, another device may perform process 192 to determine whether tachycardia has been detected and the medical device may be used to perform process 194 to provide the tachycardia-related therapy.
The method 200 may include process 202, which may be similar to process 176 of
The method 200 may further include process 204 to deliver shock therapy. Shock therapy may be initiated using the medical device. For example, the medical device may deliver a signaling pulse (e.g., a distinctive single, high-output pacing pulse to the ventricle) or other trigger. The pacing signal or other trigger may be detected by the separate medical device, which may provide the electrical shock.
The method 200 may further include process 206 to deliver anti-tachycardia pacing therapy (ATP). The ATP may be delivered using the plurality of electrodes of the medical device. After process 206, the method 200 may continue with process 208.
The method 200 may include process 208 to determine whether the V rhythm exceeds a threshold after ATP delivery has begun in process 206. In particular, a V rhythm threshold may be used to distinguish monomorphic VT from other types of tachycardia, in the same or similar manner as process 156 of method 150 (
The method may further include process 210 to monitor tachycardia. For example, process 210 may include performing the method 170 of
The method 220 may begin with process 222, which determines whether a pacing signal has been detected. As described with respect to process 204 of
The method 220 may further include process 224 to withhold therapy. In particular, process 224 may withhold shock therapy from being delivered by the separate medical device (e.g., extravascular ICD).
The method 220 may further include process 226 to deliver a shock to cardiac tissue of the patient's heart. In particular, the separate medical device may be used to provide the shock as, e.g., the medical device may not have a sufficient battery capacity, size, or positioning sufficient to deliver an effective cardioversion or defibrillation shock.
In some embodiments, any of the tissue-piercing electrodes of the present disclosure may be implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart. In particular, the tissue-piercing electrode may be implanted from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body.
Once implanted, the tissue-piercing electrode may be positioned in the target implant region 4 (
In some embodiments, the tissue-piercing electrode may be positioned in the basal septal region of the left ventricular myocardium when implanted. The basal septal region may include one or more of the basal anteroseptal area 2, basal inferoseptal area 3, mid-anteroseptal area 8, and mid-inferoseptal area 9.
In some embodiments, the tissue-piercing electrode may be positioned in the high inferior/posterior basal septal region of the left ventricular myocardium when implanted. The high inferior/posterior basal septal region of the left ventricular myocardium may include a portion of at least one of the basal inferoseptal area 3 and mid-inferoseptal area 9. For example, the high inferior/posterior basal septal region may include region 324 illustrated generally as a dashed-line boundary. As shown, the dashed line boundary represents an approximation of about where the high inferior/posterior basal septal region and may take somewhat different shape or size depending on the particular application. Without being bound by any particular theory, intraventricular synchronous pacing and/or activation may result from stimulating the high septal ventricular myocardium due to functional electrical coupling between the subendocardial Purkinje fibers and the ventricular myocardium.
With reference to
With reference to
With reference to
The device may initiate or switch to a triggered pacing mode in state 506, in which the device delivers pacing in response to a trigger (e.g., pacing signal) from a separate device (e.g., an ICD). In some embodiments, the implantable medical device may include only electrodes to pace the LV (e.g., tissue-piercing electrode), which is triggered by a separate, or remote, device (e.g., a subcutaneous or leaded device) that determines timing and sends a command or trigger to the implantable medical device to pace the LV to deliver CRT. The device may return to the nominal state 502 from state 506.
Further, the device may initiate or switch to an asynchronous pacing mode in state 508, in which the device delivers pacing independent of sensing in other chambers. The device may return to the nominal state 502 from state 508.
Reference will now be made to
Although not described herein, the illustrative system 1100 may further include imaging apparatus. The imaging apparatus may be any type of imaging apparatus configured to image, or provide images of, at least a portion of the patient in a noninvasive manner. For example, the imaging apparatus may not use any components or parts that may be located within the patient to provide images of the patient except noninvasive tools such as contrast solution. It is to be understood that the illustrative systems, methods, and interfaces described herein may further use imaging apparatus to provide noninvasive assistance to a user (e.g., a physician) to locate and position a device to deliver VfA cardiac pacing therapy and/or to locate or select a pacing electrode or pacing vector proximate the patient's heart for Ventricle from atrium pacing therapy in conjunction with the evaluation of Ventricle from atrium pacing therapy.
For example, the illustrative systems, methods, and interfaces may provide image guided navigation that may be used to navigate leads including leadless devices, electrodes, leadless electrodes, wireless electrodes, catheters, etc., within the patient's body while also providing noninvasive cardiac therapy evaluation including determining whether a ventricle from atrium (VfA) paced setting is acceptable or determining whether one or more selected parameters are acceptable, such as selected location information (e.g., location information for the electrodes to target a particular location in the left ventricle). Illustrative systems and methods that use imaging apparatus and/or electrode apparatus may be described in U.S. Patent Publication No. 2014/0371832 filed on Jun. 12, 2013 and entitled “Implantable Electrode Location Selection,” U.S. Patent Publication No. 2014/0371833 filed on Jun. 12, 2013 and entitled “Implantable Electrode Location Selection,” U.S. Patent Publication No. 2014/0323892 filed on Mar. 27, 2014 and entitled “Systems, Methods, and Interfaces for Identifying Effective Electrodes,” U.S. Patent Publication No. 2014/0323882 filed on Mar. 27, 2014 and entitled “Systems, Methods, and Interfaces for Identifying Optical Electrical Vectors,” each of which is incorporated herein by reference in its entirety.
Illustrative imaging apparatus may be configured to capture x-ray images and/or any other alternative imaging modality. For example, the imaging apparatus may be configured to capture images, or image data, using isocentric fluoroscopy, bi-plane fluoroscopy, ultrasound, computed tomography (CT), multi-slice computed tomography (MSCT), magnetic resonance imaging (MRI), high frequency ultrasound (HIFU), optical coherence tomography (OCT), intra-vascular ultrasound (IVUS), two dimensional (2D) ultrasound, three dimensional (3D) ultrasound, four dimensional (4D) ultrasound, intraoperative CT, intraoperative MRI, etc. Further, it is to be understood that the imaging apparatus may be configured to capture a plurality of consecutive images (e.g., continuously) to provide video frame data. In other words, a plurality of images taken over time using the imaging apparatus may provide video frame, or motion picture, data. Additionally, the images may also be obtained and displayed in two, three, or four dimensions. In more advanced forms, four-dimensional surface rendering of the heart or other regions of the body may also be achieved by incorporating heart data or other soft tissue data from a map or from pre-operative image data captured by MRI, CT, or echocardiography modalities. Image datasets from hybrid modalities, such as positron emission tomography (PET) combined with CT, or single photon emission computer tomography (SPECT) combined with CT, could also provide functional image data superimposed onto anatomical data, e.g., to be used to navigate treatment apparatus proximate target locations (e.g., such as locations within the left ventricle, including a selected location within the high posterior basal septal area of the left ventricular cavity) within the heart or other areas of interest.
Systems and/or imaging apparatus that may be used in conjunction with the illustrative systems and method described herein are described in U.S. Pat. App. Pub. No. 2005/0008210 to Evron et al. published on Jan. 13, 2005, U.S. Pat. App. Pub. No. 2006/0074285 to Zarkh et al. published on Apr. 6, 2006, U.S. Pat. App. Pub. No. 2011/0112398 to Zarkh et al. published on May 12, 2011, U.S. Pat. App. Pub. No. 2013/0116739 to Brada et al. published on May 9, 2013, U.S. Pat. No. 6,980,675 to Evron et al. issued on Dec. 27, 2005, U.S. Pat. No. 7,286,866 to Okerlund et al. issued on Oct. 23, 2007, U.S. Pat. No. 7,308,297 to Reddy et al. issued on Dec. 11, 2011, U.S. Pat. No. 7,308,299 to Burrell et al. issued on Dec. 11, 2011, U.S. Pat. No. 7,321,677 to Evron et al. issued on Jan. 22, 2008, U.S. Pat. No. 7,346,381 to Okerlund et al. issued on Mar. 18, 2008, U.S. Pat. No. 7,454,248 to Burrell et al. issued on Nov. 18, 2008, U.S. Pat. No. 7,499,743 to Vass et al. issued on Mar. 3, 2009, U.S. Pat. No. 7,565,190 to Okerlund et al. issued on Jul. 21, 2009, U.S. Pat. No. 7,587,074 to Zarkh et al. issued on Sep. 8, 2009, U.S. Pat. No. 7,599,730 to Hunter et al. issued on Oct. 6, 2009, U.S. Pat. No. 7,613,500 to Vass et al. issued on Nov. 3, 2009, U.S. Pat. No. 7,742,629 to Zarkh et al. issued on Jun. 22, 2010, U.S. Pat. No. 7,747,047 to Okerlund et al. issued on Jun. 29, 2010, U.S. Pat. No. 7,778,685 to Evron et al. issued on Aug. 17, 2010, U.S. Pat. No. 7,778,686 to Vass et al. issued on Aug. 17, 2010, U.S. Pat. No. 7,813,785 to Okerlund et al. issued on Oct. 12, 2010, U.S. Pat. No. 7,996,063 to Vass et al. issued on Aug. 9, 2011, U.S. Pat. No. 8,060,185 to Hunter et al. issued on Nov. 15, 2011, and U.S. Pat. No. 8,401,616 to Verard et al. issued on Mar. 19, 2013, each of which is incorporated herein by reference in its entirety.
The display apparatus 1130 and the computing apparatus 1140 may be configured to display and analyze data such as, e.g., electrical signals (e.g., electrocardiogram data), cardiac information representative of at least one of mechanical cardiac functionality and electrical cardiac functionality, etc. Cardiac information may include, e.g., electrical heterogeneity information or electrical dyssynchrony information, surrogate electrical activation information or data, etc. that is generated using electrical signals gathered, monitored, or collected, using the electrode apparatus 1110. In at least one embodiment, the computing apparatus 1140 may be a server, a personal computer, or a tablet computer. The computing apparatus 1140 may be configured to receive input from input apparatus 1142 and transmit output to the display apparatus 1130. Further, the computing apparatus 1140 may include data storage that may allow for access to processing programs or routines and/or one or more other types of data, e.g., for driving a graphical user interface configured to noninvasively assist a user in targeting placement of a pacing device and/or evaluating pacing therapy at that location (e.g., the location of an implantable electrode used for pacing, the location of pacing therapy delivered by a particular pacing vector, etc.).
The computing apparatus 1140 may be operatively coupled to the input apparatus 1142 and the display apparatus 1130 to, e.g., transmit data to and from each of the input apparatus 1142 and the display apparatus 1130. For example, the computing apparatus 1140 may be electrically coupled to each of the input apparatus 1142 and the display apparatus 1130 using, e.g., analog electrical connections, digital electrical connections, wireless connections, bus-based connections, network-based connections, internet-based connections, etc. As described further herein, a user may provide input to the input apparatus 1142 to manipulate, or modify, one or more graphical depictions displayed on the display apparatus 1130 and to view and/or select one or more pieces of information related to the cardiac therapy.
Although as depicted the input apparatus 1142 is a keyboard, it is to be understood that the input apparatus 1142 may include any apparatus capable of providing input to the computing apparatus 1140 to perform the functionality, methods, and/or logic described herein. For example, the input apparatus 1142 may include a mouse, a trackball, a touchscreen (e.g., capacitive touchscreen, a resistive touchscreen, a multi-touch touchscreen, etc.), etc. Likewise, the display apparatus 1130 may include any apparatus capable of displaying information to a user, such as a graphical user interface 1132 including cardiac information, textual instructions, graphical depictions of electrical activation information, graphical depictions of anatomy of a human heart, images or graphical depictions of the patient's heart, graphical depictions of a leadless and/or leaded pacing device being positioned or placed to provide VfA pacing therapy, graphical depictions of locations of one or more electrodes, graphical depictions of a human torso, images or graphical depictions of the patient's torso, graphical depictions or actual images of implanted electrodes and/or leads, etc. Further, the display apparatus 1130 may include a liquid crystal display, an organic light-emitting diode screen, a touchscreen, a cathode ray tube display, etc.
The processing programs or routines stored and/or executed by the computing apparatus 1140 may include programs or routines for computational mathematics, matrix mathematics, dispersion determinations (e.g., standard deviations, variances, ranges, interquartile ranges, mean absolute differences, average absolute deviations, etc.), filtering algorithms, maximum value determinations, minimum value determinations, threshold determinations, moving windowing algorithms, decomposition algorithms, compression algorithms (e.g., data compression algorithms), calibration algorithms, image construction algorithms, signal processing algorithms (e.g., various filtering algorithms, Fourier transforms, fast Fourier transforms, etc.), standardization algorithms, comparison algorithms, vector mathematics, or any other processing required to implement one or more illustrative methods and/or processes described herein. Data stored and/or used by the computing apparatus 1140 may include, for example, electrical signal/waveform data from the electrode apparatus 1110, dispersions signals, windowed dispersions signals, parts or portions of various signals, electrical activation times from the electrode apparatus 1110, graphics (e.g., graphical elements, icons, buttons, windows, dialogs, pull-down menus, graphic areas, graphic regions, 3D graphics, etc.), graphical user interfaces, results from one or more processing programs or routines employed according to the disclosure herein (e.g., electrical signals, cardiac information, etc.), or any other data that may be necessary for carrying out the one and/or more processes or methods described herein.
In one or more embodiments, the illustrative systems, methods, and interfaces may be implemented using one or more computer programs executed on programmable computers, such as computers that include, for example, processing capabilities, data storage (e.g., volatile or non-volatile memory and/or storage elements), input devices, and output devices. Program code and/or logic described herein may be applied to input data to perform functionality described herein and generate desired output information. The output information may be applied as input to one or more other devices and/or methods as described herein or as would be applied in a known fashion.
The one or more programs used to implement the systems, methods, and/or interfaces described herein may be provided using any programmable language, e.g., a high-level procedural and/or object orientated programming language that is suitable for communicating with a computer system. Any such programs may, for example, be stored on any suitable device, e.g., a storage media, that is readable by a general or special purpose program running on a computer system (e.g., including processing apparatus) for configuring and operating the computer system when the suitable device is read for performing the procedures described herein. In other words, at least in one embodiment, the illustrative systems, methods, and/or interfaces may be implemented using a computer readable storage medium, configured with a computer program, where the storage medium so configured causes the computer to operate in a specific and predefined manner to perform functions described herein. Further, in at least one embodiment, the illustrative systems, methods, and/or interfaces may be described as being implemented by logic (e.g., object code) encoded in one or more non-transitory media that includes code for execution and, when executed by a processor, is operable to perform operations such as the methods, processes, and/or functionality described herein.
The computing apparatus 1140 may be, for example, any fixed or mobile computer system (e.g., a controller, a microcontroller, a personal computer, minicomputer, tablet computer, etc.) and may be generally described as including processing circuitry. The exact configuration of the computing apparatus 1140 is not limiting, and essentially any device capable of providing suitable computing capabilities and control capabilities (e.g., graphics processing, etc.) may be used. As described herein, a digital file may be any medium (e.g., volatile or non-volatile memory, a CD-ROM, a punch card, magnetic recordable medium such as a disk or tape, etc.) containing digital bits (e.g., encoded in binary, trinary, etc.) that may be readable and/or writeable by computing apparatus 1140 described herein. Also, as described herein, a file in user-readable format may be any representation of data (e.g., ASCII text, binary numbers, hexadecimal numbers, decimal numbers, graphically, etc.) presentable on any medium (e.g., paper, a display, etc.) readable and/or understandable by a user.
In view of the above, it will be readily apparent that the functionality as described in one or more embodiments according to the present disclosure may be implemented in any manner as would be known to one skilled in the art. As such, the computer language, the computer system, or any other software/hardware which is to be used to implement the processes described herein shall not be limiting on the scope of the systems, processes or programs (e.g., the functionality provided by such systems, processes or programs) described herein.
Electrical activation times of the patient's heart may be useful to evaluate a patient's cardiac condition and/or ventricle from atrium (VfA) cardiac therapy being delivered to a patient. Surrogate electrical activation information or data of one or more regions of a patient's heart may be monitored, or determined, using electrode apparatus 1110 as shown in
Further, the electrodes 1112 may be electrically connected to interface/amplifier circuitry 1116 via wired connection 1118. The interface/amplifier circuitry 1116 may be configured to amplify the signals from the electrodes 1112 and provide the signals to the computing apparatus 1140. Other illustrative systems may use a wireless connection to transmit the signals sensed by electrodes 1112 to the interface/amplifier circuitry 1116 and, in turn, the computing apparatus 1140, e.g., as channels of data. For example, the interface/amplifier circuitry 1116 may be electrically coupled to each of the computing apparatus 1140 and the display apparatus 1130 using, e.g., analog electrical connections, digital electrical connections, wireless connections, bus-based connections, network-based connections, internet-based connections, etc.
Although in the example of
The electrodes 1112 may be configured to surround the heart of the patient 1120 and record, or monitor, the electrical signals associated with the depolarization and repolarization of the heart after the signals have propagated through the torso of a patient 1120. Each of the electrodes 1112 may be used in a unipolar configuration to sense the torso-surface potentials that reflect the cardiac signals. The interface/amplifier circuitry 1116 may also be coupled to a return or indifferent electrode (not shown) that may be used in combination with each electrode 1112 for unipolar sensing. In some examples, there may be about 12 to about 50 electrodes 1112 spatially distributed around the torso of patient. Other configurations may have more or fewer electrodes 1112.
The computing apparatus 1140 may record and analyze the electrical activity (e.g., torso-surface potential signals) sensed by electrodes 1112 and amplified/conditioned by the interface/amplifier circuitry 1116. The computing apparatus 1140 may be configured to analyze the signals from the electrodes 1112 to provide as anterior and posterior electrode signals and surrogate cardiac electrical activation times, e.g., representative of actual, or local, electrical activation times of one or more regions of the patient's heart as will be further described herein. The computing apparatus 1140 may be configured to analyze the signals from the electrodes 1112 to provide as anterior-septal electrode signals and surrogate cardiac electrical activation times, e.g., representative of actual, or local, electrical activation times of one or more anterior-septal regions of the patient's heart, as will be further described herein, e.g., for use in evaluation of VfA pacing therapy. Further, the electrical signals measured at the left anterior surface location of a patient's torso may be representative, or surrogates, of electrical signals of the left anterior left ventricle region of the patient's heart, electrical signals measured at the left lateral surface location of a patient's torso may be representative, or surrogates, of electrical signals of the left lateral left ventricle region of the patient's heart, electrical signals measured at the left posterolateral surface location of a patient's torso may be representative, or surrogates, of electrical signals of the posterolateral left ventricle region of the patient's heart, and electrical signals measured at the posterior surface location of a patient's torso may be representative, or surrogates, of electrical signals of the posterior left ventricle region of the patient's heart. In one or more embodiments, measurement of activation times can be performed by measuring the period of time between an onset of cardiac depolarization (e.g., onset of QRS complex) and an appropriate fiducial point such as, e.g., a peak value, a minimum value, a minimum slope, a maximum slope, a zero crossing, a threshold crossing, etc.
Additionally, the computing apparatus 1140 may be configured to provide graphical user interfaces depicting the surrogate electrical activation times obtained using the electrode apparatus 1110. Illustrative systems, methods, and/or interfaces may noninvasively use the electrical information collected using the electrode apparatus 1110 to evaluate a patient's cardiac condition and/or ventricle from atrium pacing therapy being delivered to the patient.
The vest 1114 may be formed of fabric with the electrodes 1112 attached to the fabric. The vest 1114 may be configured to maintain the position and spacing of electrodes 1112 on the torso of the patient 1120. Further, the vest 1114 may be marked to assist in determining the location of the electrodes 1112 on the surface of the torso of the patient 1120. In one or more embodiments, the vest 1114 may include 17 or more anterior electrodes positionable proximate the anterior torso of the patient, and 39 or more posterior electrodes positionable proximate the anterior torso of the patient. In some examples, there may be about 25 electrodes 1112 to about 256 electrodes 1112 distributed around the torso of the patient 1120, though other configurations may have more or less electrodes 1112.
As described herein, the electrode apparatus 1110 may be configured to measure electrical information (e.g., electrical signals) representing different regions of a patient's heart. For example, activation times of different regions of a patient's heart can be approximated from surface electrocardiogram (ECG) activation times measured using surface electrodes in proximity to surface areas corresponding to the different regions of the patient's heart. In at least one example, activation times of the anterior-septal region of a patient's heart can be approximated from surface ECG activation times measured using surface electrodes in proximity to surface areas corresponding to the anterior-septal region of the patient's heart. That is, a portion of the set of electrodes 1112, and not the entire set, can be used to generate activation times corresponding to a particular location of the patient's heart that the portion of the set of electrodes corresponds to.
The illustrative systems, methods, and interfaces may be used to provide noninvasive assistance to a user in the evaluation of a patient's cardiac health or status, and/or the evaluation of cardiac therapy such as ventricle from atrium (VfA) pacing therapy by use of the electrode apparatus 1110 (e.g., cardiac therapy being presently-delivered to a patient during implantation or after implantation). Further, the illustrative systems, methods, and interfaces may be used to assist a user in the configuration of the cardiac therapy, such as VfA pacing therapy, being delivered to a patient.
VfA pacing can be described as providing a synchronized homogeneous activation of ventricles of the heart. As an example, patients with atrial-ventricular (AV) block or prolonged AV timings that can lead to heart failure who have otherwise intact (e.g., normal) QRS can benefit from VfA pacing therapy. In addition, as an example, VfA pacing may provide beneficial activation for heart failure patients with intrinsic ventricular conduction disorders. Further, proper placement of VfA pacing can provide optimal activation of the ventricles for such patients. Further, left ventricular (LV) resynchronization for heart failure patients with left bundle branch block (LBBB) may find that VfA pacing enables easier access to left ventricular endocardium without exposing the leadless device or lead to endocardial blood pool. At the same time, in that example, this can help engage part of the conduction system to potentially correct LBBB and effectively resynchronize the patient.
The method 600 may include filtering the motion signal within the atrial contraction detection window, rectifying the filtered signal, and generating a derivative signal of the filtered and rectified motion signal within the atrial contraction detection window 634. The method 600 may include determining whether an amplitude of the derivative signal within the atrial contraction detection window exceeds a threshold 636. In response to determining that the amplitude of the derivative signal within the atrial contraction detection window exceeds the threshold (YES of 636), the method 600 may proceed to detecting atrial contraction 638. Otherwise (NO of 636), the method 600 may return to filtering, rectifying, and generating a derivative signal 634. Various techniques for using a motion detector that provides a motion signal may be described in U.S. Pat. No. 9,399,140 (Cho et al.), issued Jul. 26, 2016, entitled “Atrial contraction detection by a ventricular leadless pacing device for atrio-synchronous ventricular pacing,” which is incorporated herein by reference in its entirety.
While the present disclosure is not so limited, an appreciation of various aspects of the disclosure of the present application will be gained through a discussion of some illustrative embodiments provided below.
Various illustrative embodiments are directed to atrioventricular synchronous pacing.
In illustrative embodiment 1, an implantable medical device includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to at least one of deliver cardiac therapy to and sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode positionable within the right atrium to at least one of deliver cardiac therapy and sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to monitor electrical activity of the right atrium using the right atrial electrode and deliver atrioventricular synchronous pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored electrical activity of the right atrium.
In illustrative embodiment 2, a method includes monitoring activity of the right atrium of a patient's heart using a right atrial electrode or a right atrial motion detector and delivering atrioventricular synchronous pacing using at least a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body including pacing one or both ventricles using at least the tissue-piercing electrode based on the monitored activity of the right atrium.
In illustrative embodiment 3, a device or method of any preceding illustrative embodiment is included, wherein delivering atrioventricular synchronous pacing includes using the right atrial electrode to pace the right atrium.
In illustrative embodiment 4, a device or method of any preceding illustrative embodiment is included, wherein delivering atrioventricular synchronous pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored electrical activity of the right atrium includes sensing an atrial event within the monitored electrical activity of the right atrium and delivering a pace to one or both ventricles in response to the sensed atrial event.
In illustrative embodiment 5, a device or method of illustrative embodiment 4 is included, wherein delivering the pace to one or both ventricles in response to the sensed atrial event includes delivering the pace to one or both ventricles after a selected A-V time period has elapsed from the sensed atrial event.
In illustrative embodiment 6, a device or method of any preceding illustrative embodiment is included, wherein the controller is further configured to perform, or the method further includes, monitoring electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium using the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body; sensing a ventricular event within the monitored electrical activity from using the tissue-piercing electrode; and withholding delivering the pace to one or both ventricles in response to sensing the ventricular event within the monitored electrical activity from using the tissue-piercing electrode.
In illustrative embodiment 7, a device or method of any preceding illustrative embodiment is included, wherein the controller is further configured to perform, or the method further includes, detecting atrial fibrillation and initiating a single chamber pacing mode.
In illustrative embodiment 8, a device or method of any preceding illustrative embodiment is included, wherein the controller is further configured to perform, or the method further includes, receiving a trigger from a separate medical device in a triggered pacing mode.
In illustrative embodiment 8, a device or method of any preceding illustrative embodiment is included, wherein the controller is further configured to perform, or the method further includes, delivering pacing in an asynchronous pacing node.
In illustrative embodiment 9, a device of any preceding illustrative embodiment is included, further including a housing extending from a proximal end region to a distal end region. The right atrial electrode is leadlessly coupled to the housing and the tissue-piercing electrode is leadlessly coupled to the distal end region of the housing. The therapy delivery circuit, the sensing circuit, and the controller are located within the housing.
In illustrative embodiment 10, the device of illustrative embodiment 9 is included, further including a fixation member that extends from the housing. The fixation member is configured to pierce into the myocardium. The fixation member extends from the distal end region of the housing toward a distal tip of the tissue-piercing electrode.
In illustrative embodiment 11, a device of any preceding illustrative embodiment is included, further including a housing, wherein the therapy delivery circuit, the sensing circuit, and the controller are located within the housing. The device further includes a lead coupled to and extending from the housing to a distal end region. The tissue-piercing electrode and the right atrial electrode are coupled to the distal end region of the lead.
In illustrative embodiment 12, a device of any preceding illustrative embodiment is included, further including a housing, wherein the therapy delivery circuit, the sensing circuit, and the controller are located within the housing. The device further includes a first lead coupled to and extending from the housing to a first distal end region and a second lead coupled to and extending from the housing to a second distal end region. The tissue-piercing electrode is coupled to the first distal end region of the first lead. The right atrial electrode is coupled to the second distal end region of the second lead.
In illustrative embodiment 13, a device of any preceding illustrative embodiment is included, further including a housing, wherein the therapy delivery circuit, the sensing circuit, and the controller are located within the housing. The device further includes a first lead coupled to and extending from the housing to a first distal end region, a second lead coupled to and extending from the housing to a second distal end region, and a third lead coupled to and extending from the housing to a third distal end region. The plurality of electrodes further includes a right ventricular electrode to deliver cardiac therapy to or sense electrical activity of the right ventricle of the patient's heart coupled to the third distal end region of the third lead. The tissue-piercing electrode is coupled to the first distal end region of the first lead. The right atrial electrode is coupled to the second distal end region of the second lead.
In illustrative embodiment 14, an implantable medical device includes a housing extending from a proximal end region to a distal end region. The device also includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode leadlessly coupled to the distal end region of the housing and implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode leadlessly coupled to the housing and positionable within the right atrium to deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit within the housing operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit within the housing operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry within the housing operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to monitor electrical activity of the right atrium using the right atrial electrode and deliver atrioventricular synchronous pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored electrical activity of the right atrium.
In illustrative embodiment 15, an implantable medical device includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to at least one of deliver cardiac therapy to and sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The tissue-piercing electrode also includes a right atrial motion detector positionable within the right atrium to sense mechanical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to monitor mechanical activity of the right atrium using the right atrial motion detector and deliver atrioventricular synchronous pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored mechanical activity of the right atrium.
Various illustrative embodiments are directed to cardiac resynchronization pacing.
In illustrative embodiment 16, an implantable medical device includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to at least one of deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode positionable within the right atrium to at least one of deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to monitor at least one of electrical activity of the right atrium using the right atrial electrode and electrical activity of the left ventricle using the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The controller is also configured to deliver cardiac resynchronization pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored electrical activity.
In illustrative embodiment 17, a method includes monitoring at least one of electrical activity of the right atrium of a patient's heart using a right atrial electrode and electrical activity of the left ventricle using a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The method also includes delivering cardiac resynchronization pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body including pacing one or both ventricles based on the monitored electrical activity.
In illustrative embodiment 18, a device or method of any preceding illustrative embodiment is included, wherein the controller is further configured to perform, or the method further includes, monitoring far-field electrical activity of the right ventricle using the right atrial electrode.
In illustrative embodiment 19, a device or method of any illustrative embodiment 16-18 is included, wherein delivering cardiac resynchronization pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored electrical activity includes sensing an atrial event within the monitored electrical activity of the right atrium and delivering a pace to one or both ventricles in response to the sensed atrial event to provide cardiac resynchronization.
In illustrative embodiment 20, a device or method of any illustrative embodiment 16-19 is included, wherein delivering cardiac resynchronization pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored electrical activity includes sensing a ventricular event within the monitored electrical activity from using the tissue-piercing electrode and delivering a pace to one or both ventricles in response to the sensed ventricular event to provide cardiac resynchronization.
In illustrative embodiment 21, the device or method of illustrative embodiment 20 is included, wherein delivering a pace to one or both ventricles in response to the sensed ventricular event includes delivering the pace to one or both ventricles after a selected time period has elapsed from the sensed ventricular event.
In illustrative embodiment 22, a device or method of any illustrative embodiment 16-21 is included, wherein the controller is further configured to perform, or the method further includes, detecting atrial fibrillation and initiating a single chamber pacing mode.
In illustrative embodiment 23, a device or method of any illustrative embodiment 16-22 is included, wherein the controller is further configured to perform, or the method further includes, receiving a trigger from a separate medical device in a triggered pacing mode.
In illustrative embodiment 24, a device or method ofany illustrative embodiment 16223 is included, wherein the controller is further configured to perform, or the method further includes, delivering pacing in an asynchronous pacing mode.
In illustrative embodiment 25, a device of any illustrative embodiment 16-24 is included, further including a housing extending from a proximal end region to a distal end region. The right atrial electrode is leadlessly coupled to the housing and the tissue-piercing electrode is leadlessly coupled to the distal end region of the housing. The therapy delivery circuit, the sensing circuit, and the controller are located within the housing.
In illustrative embodiment 26, the device of illustrative embodiment 25 is included, further including a fixation member that extends from the housing. The fixation member is configured to pierce into the myocardium. The fixation member extends from the distal end region of the housing toward a distal tip of the tissue-piercing electrode.
In illustrative embodiment 27, a device of any illustrative embodiment 16-26 is included, further including a housing, wherein the therapy delivery circuit, the sensing circuit, and the controller are located within the housing. The device further includes a lead coupled to and extending from the housing to a distal end region. The tissue-piercing electrode and the right atrial electrode are coupled to the distal end region of the lead.
In illustrative embodiment 28, a device of any illustrative embodiment 16-27 is included, further including a housing, wherein the therapy delivery circuit, the sensing circuit, and the controller are located within the housing. The device further includes a first lead coupled to and extending from the housing to a first distal end region and a second lead coupled to and extending from the housing to a second distal end region. The tissue-piercing electrode is coupled to the first distal end region of the first lead. The right atrial electrode is coupled to the second distal end region of the second lead.
In illustrative embodiment 29, a device of any illustrative embodiment 16-28 is included, further including a housing, wherein the therapy delivery circuit, the sensing circuit, and the controller are located within the housing. The device further includes a first lead coupled to and extending from the housing to a first distal end region, a second lead coupled to and extending from the housing to a second distal end region, and a third lead coupled to and extending from the housing to a third distal end region. The plurality of electrodes further includes a right ventricular electrode to deliver cardiac therapy to or sense electrical activity of the right ventricle of the patient's heart coupled to the third distal end region of the third lead. The tissue-piercing electrode is coupled to the first distal end region of the first lead. The right atrial electrode is coupled to the second distal end region of the second lead.
In illustrative embodiment 30, an implantable medical device includes a housing extending from a proximal end region to a distal end region. The implantable medical device also includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode leadlessly coupled to the distal end region of the housing and implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode leadlessly coupled to the housing and positionable within the right atrium to deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit within the housing operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit within the housing operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry within the housing operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to monitor at least one of electrical activity of the right atrium using the right atrial electrode and electrical activity of the left ventricle using the tissue-piercing electrode in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body. The controller is further configured to deliver cardiac resynchronization pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored electrical activity.
In illustrative embodiment 31, an implantable medical device includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to at least one of deliver cardiac therapy to and sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial motion detector positionable within the right atrium to sense mechanical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to monitor mechanical activity of the right atrium using the right atrial motion detector and deliver cardiac resynchronization pacing using at least the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to pace one or both ventricles based on the monitored mechanical activity of the right atrium.
Various illustrative embodiments are directed to tachycardia therapy.
In illustrative embodiment 32, an implantable medical device includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode positionable within the right atrium to deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to: monitor electrical activity of the right atrium using the right atrial electrode; monitor electrical activity of the left ventricle using the tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium; and deliver tachycardia therapy based on the monitored electrical activities of the right atrium and the left ventricle.
In illustrative embodiment 33, a method includes monitoring electrical activity of the right atrium of a patient's heart using a right atrial electrode; monitoring electrical activity of the left ventricle of the patient's heart using a tissue-piercing electrode implanted in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium; and deliver tachycardia therapy based on the monitored electrical activities of the right atrium and the left ventricle.
In illustrative embodiment 34, a device or method of any illustrative embodiment 32-33 is include, wherein the controller is farther configured to perform, or the method further includes, delivering tachycardia therapy based on the monitored electrical activities of the right atrium and left ventricle includes delivering at least one of anti-tachycardia pacing therapy using the plurality of electrodes and shock therapy using a separate medical device.
In illustrative embodiment 35, a device or method of any illustrative embodiment 32-34 is included, wherein the controller is further configured to perform, or the method further includes, withholding tachycardia therapy in response to a determining that a cardiac rhythm of the patient's heart has 1:1 atrioventricular conduction.
In illustrative embodiment 36, a device of any illustrative embodiment 32-35 is included, further including a housing extending from a proximal end region to a distal end region, wherein the right atrial electrode is leadlessly coupled to the housing and the tissue-piercing electrode is leadlessly coupled to the distal end region of the housing, wherein the therapy delivery circuit, the sensing circuit, and the controller are enclosed within the housing.
In illustrative embodiment 37, the device of illustrative embodiment 36 is included, further including a fixation member that extends from the housing. The fixation member is configured to pierce into the myocardium. The fixation member extends from the distal end region of the housing toward a distal tip of the tissue-piercing electrode.
In illustrative embodiment 38, a device of any illustrative embodiment 32-37 is included, further including a housing, wherein the therapy delivery circuit, the sensing circuit, and the controller are located within the housing. The device further includes a lead coupled to and extending from the housing to a distal end region. The tissue-piercing electrode and the right atrial electrode are coupled to the distal end region of the lead.
In illustrative embodiment 39, a device of any illustrative embodiment 32-38 is included, further including a housing, wherein the therapy delivery circuit, the sensing circuit, and the controller are located within the housing. The device further includes a first lead coupled to and extending from the housing to a first distal end region and a second lead coupled to and extending from the housing to a second distal end region. The tissue-piercing electrode is coupled to the first distal end region of the first lead. The right atrial electrode is coupled to the second distal end region of the second lead.
In illustrative embodiment 40, a device of any illustrative embodiment 32-39 is included, further including a housing, wherein the therapy delivery circuit, the sensing circuit, and the controller are located within the housing. The device further includes a first lead coupled to and extending from the housing to a first distal end region, a second lead coupled to and extending from the housing to a second distal end region, and a third lead coupled to and extending from the housing to a third distal end region. The plurality of electrodes further includes a right ventricular electrode to deliver cardiac therapy to or sense electrical activity of the right ventricle of the patient's heart coupled to the third distal end region of the third lead. The tissue-piercing electrode is coupled to the first distal end region of the first lead. The right atrial electrode is coupled to the second distal end region of the second lead.
In illustrative embodiment 41, an implantable medical device includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode positionable within the right atrium to deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to: monitor electrical activity of the right atrium using the right atrial electrode; monitor electrical activity of the left ventricle using the tissue-piercing electrode implanted to sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body; and determine tachycardia of the patient's heart based on the monitored electrical activities of the right atrium and the left ventricle.
In illustrative embodiment 42, a method includes monitoring electrical activity of the right atrium of a patient's heart using a right atrial electrode; monitoring electrical activity of the left ventricle of the patient's heart using a tissue-piercing electrode implanted to sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of the patient's heart from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body; and determining tachycardia of the patient's heart based on the monitored electrical activities of the right atrium and the left ventricle.
In illustrative embodiment 43, a device or method of any illustrative embodiment 41-42 is included, wherein the controller is further configured to perform, or the method further includes, determining whether a cardiac rhythm of the patient's heart has 1:1 atrioventricular conduction.
In illustrative embodiment 44, a device or method of illustrative embodiment 43 is included, wherein the controller is further configured to perform, or the method further includes, determining appropriate tachycardia therapy based on the monitored electrical activities of the right atrium and the left ventricle in response to the cardiac rhythm not having 1:1 atrioventricular conduction.
In illustrative embodiment 45, a device or method of any illustrative embodiment 41-44 is included, wherein determining tachycardia of the patient's heart based on the monitored electrical activities of the right atrium and the left ventricle includes determining that an atrial rhythm is regular and that a ventricular rhythm exceeds a selected ventricular rhythm threshold.
In illustrative embodiment 46, a device or method of any illustrative embodiment 41-45 is included, wherein the controller is further configured to perform, or the method further includes, delivering tachycardia therapy in response to determining tachycardia of the patient's heart.
In illustrative embodiment 47, a device or method of illustrative embodiment 46 is included, wherein the controller is further configured to perform, or the method further includes, delivering anti-tachycardia pacing therapy in response to a regular V-V event interval and a regular electrogram morphology.
In illustrative embodiment 48, a device or method of any illustrative embodiment 46-47 is included, wherein the controller is further configured to perform, or the method further includes, delivering shock therapy using a separate medical device in response to at least one of an irregular V-V event interval and an irregular electrogram morphology.
In illustrative embodiment 49, an implantable medical device includes a plurality of electrodes. The plurality of electrodes includes a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart. The plurality of electrodes also includes a right atrial electrode positionable within the right atrium to deliver cardiac therapy to or sense electrical activity of the right atrium of the patient's heart. The implantable medical device also includes a therapy delivery circuit operably coupled to the plurality of electrodes to deliver cardiac therapy to the patient's heart and a sensing circuit operably coupled to the plurality of electrodes to sense electrical activity of the patient's heart. The implantable medical device further includes a controller including processing circuitry operably coupled to the therapy delivery circuit and the sensing circuit. The controller is configured to deliver at least one of anti-tachycardia pacing therapy using the plurality of electrodes and shock therapy using a separate medical device.
In illustrative embodiment 50, a method includes delivering at least one of anti-tachycardia pacing therapy and shock therapy using a separate medical device using at least a tissue-piercing electrode implantable from the triangle of Koch region of the right atrium through the right atrial endocardium and central fibrous body to deliver cardiac therapy to or sense electrical activity of the left ventricle in the basal and/or septal region of the left ventricular myocardium of a patient's heart.
In illustrative embodiment 51, a device or method of any illustrative embodiment 49-59 is included, wherein the controller is further configured to perform, or the method further includes, detecting whether a ventricular rhythm exceeds a selected ventricular rhythm threshold after beginning to deliver anti-tachycardia pacing therapy.
In illustrative embodiment 52, a device or method of any illustrative embodiment 49-51 is included, wherein the controller is further configured to perform, or the method further includes, monitoring for tachycardia in response to detecting a regular ventricular rhythm.
In illustrative embodiment 53, a device or method of any illustrative embodiment 49-52 is included, wherein the controller is further configured to perform, or the method further includes, delivering shock therapy using a separate device therapy in response to detecting a ventricular rhythm that exceeds the selected ventricular rhythm threshold.
In illustrative embodiment 54, a device or method of any illustrative embodiment 49-53 is included, wherein the shock therapy includes delivering a signaling pulse to the left ventricle using the tissue-piercing electrode.
In illustrative embodiment 55, a device or method of illustrative embodiment 54 is included, wherein the signaling pulse is configured to be detected by the separate medical device to trigger delivery of a shock from the separate medical device to the cardiac tissue.
In illustrative embodiment 56, a device or method of any illustrative embodiment 49-54 is included, wherein the separate medical device is not connected to the implantable medical device by a metal conductor.
Thus, various embodiments of VFA CARDIAC THERAPY are disclosed. Although reference is made herein to the accompanying set of drawings that form part of this disclosure, one of at least ordinary skill in the art will appreciate that various adaptations and modifications of the embodiments described herein are within, or do not depart from, the scope of this disclosure. For example, aspects of the embodiments described herein may be combined in a variety of ways with each other. Therefore, it is to be understood that, within the scope of the appended claims, the claimed invention may be practiced other than as explicitly described herein.
It will be understood that each block of the block diagrams and combinations of those blocks can be implemented by means for performing the illustrated function.
All references and publications cited herein are expressly incorporated herein by reference in their entirety into this disclosure, except to the extent they may directly contradict this disclosure.
All scientific and technical terms used herein have meanings commonly used in the art unless otherwise specified. The definitions provided herein are to facilitate understanding of certain terms used frequently herein and are not meant to limit the scope of the present disclosure.
Unless otherwise indicated, all numbers expressing feature sizes, amounts, and physical properties used in the specification and claims may be understood as being modified either by the term “exactly” or “about.” Accordingly, unless indicated to the contrary, the numerical parameters set forth in the foregoing specification and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by those skilled in the art utilizing the teachings disclosed herein or, for example, within typical ranges of experimental error.
The recitation of numerical ranges by endpoints includes all numbers subsumed within that range (e.g., 1 to 5 includes 1, 1.5, 2, 2.75, 3, 3.80, 4, and 5) and any range within that range. Herein, the terms “up to” or “no greater than” a number (e.g., up to 50) includes the number (e.g., 50), and the term “no less than” a number (e.g., no less than 5) includes the number (e.g., 5).
The terms “coupled” or “connected” refer to elements being attached to each other either directly (in direct contact with each other) or indirectly (having one or more elements between and attaching the two elements). Either term may be modified by “operatively” and “operably,” which may be used interchangeably, to describe that the coupling or connection is configured to allow the components to interact to carry out at least some functionality (for example, an intracardiac medical device may be operatively or operably coupled to an extravascular ICD to initiate shock therapy).
Reference to “one embodiment,” “an embodiment,” “certain embodiments,” or “some embodiments,” etc., means that a particular feature, configuration, composition, or characteristic described in connection with the embodiment is included in at least one embodiment of the disclosure. Thus, the appearances of such phrases in various places throughout are not necessarily referring to the same embodiment of the disclosure. Furthermore, the particular features, configurations, compositions, or characteristics may be combined in any suitable manner in one or more embodiments.
The words “preferred” and “preferably” refer to embodiments of the disclosure that may afford certain benefits, under certain circumstances. However, other embodiments may also be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful and is not intended to exclude other embodiments from the scope of the disclosure.
As used in this specification and the appended claims, the singular forms “a,” “an,” and “the” encompass embodiments having plural referents, unless the content clearly dictates otherwise. As used in this specification and the appended claims, the term “or” is generally employed in its sense including “and/or” unless the content clearly dictates otherwise.
As used herein, “have,” “having,” “include,” “including,” “comprise,” “comprising” or the like are used in their open-ended sense, and generally mean “including, but not limited to.” It will be understood that “consisting essentially of,” “consisting of,” and the like are subsumed in “comprising,” and the like.
The term “and/of” means one or all of the listed elements or a combination of at least two of the listed elements.
The phrases “at least one of,” “comprises at least one of,” and “one or more of” followed by a list refers to any one of the items in the list and any combination of two or more items in the list.
This application is a divisional application of U.S. application Ser. No. 16/361,996, filed Mar. 22, 2019, now allowed, which claims the benefit of U.S. Provisional Application Ser. No. 62/647,441, filed Mar. 23, 2018, both of which are incorporated herein by reference in their entirety.
| Number | Name | Date | Kind |
|---|---|---|---|
| 3835864 | Rasor et al. | Sep 1974 | A |
| 3865118 | Bures | Feb 1975 | A |
| 3943936 | Rasor et al. | Mar 1976 | A |
| 3949757 | Sabel | Apr 1976 | A |
| 4142530 | Wittkampf | Mar 1979 | A |
| 4151513 | Menken et al. | Apr 1979 | A |
| 4157720 | Greatbatch | Jun 1979 | A |
| RE30366 | Rasor et al. | Aug 1980 | E |
| 4243045 | Mass | Jan 1981 | A |
| 4250884 | Hartlaub et al. | Feb 1981 | A |
| 4256115 | Bilitch | Mar 1981 | A |
| 4263919 | Levin | Apr 1981 | A |
| 4280502 | Baker, Jr. et al. | Jul 1981 | A |
| 4289144 | Gilman | Sep 1981 | A |
| 4310000 | Lindemans | Jan 1982 | A |
| 4312354 | Walters | Jan 1982 | A |
| 4323081 | Wiebusch | Apr 1982 | A |
| 4332259 | McCorkle, Jr. | Jun 1982 | A |
| 4357946 | Dutcher et al. | Nov 1982 | A |
| 4365639 | Goldreyer | Dec 1982 | A |
| 4374382 | Markowitz et al. | Feb 1983 | A |
| 4393883 | Smyth et al. | Jul 1983 | A |
| 4440173 | Hudziak et al. | Apr 1984 | A |
| 4476868 | Thompson | Oct 1984 | A |
| 4479500 | Smits | Oct 1984 | A |
| 4522208 | Buffet | Jun 1985 | A |
| 4537200 | Widrow | Aug 1985 | A |
| 4546777 | Groch et al. | Oct 1985 | A |
| 4556063 | Thompson et al. | Dec 1985 | A |
| 4562841 | Brockway et al. | Jan 1986 | A |
| 4574814 | Buffet | Mar 1986 | A |
| 4593702 | Kepski et al. | Jun 1986 | A |
| 4593955 | Leiber | Jun 1986 | A |
| 4630611 | King | Dec 1986 | A |
| 4635639 | Hakala et al. | Jan 1987 | A |
| 4674508 | DeCote | Jun 1987 | A |
| 4712554 | Garson | Dec 1987 | A |
| 4729376 | DeCote | Mar 1988 | A |
| 4754753 | King | Jul 1988 | A |
| 4759366 | Callaghan | Jul 1988 | A |
| 4776338 | Lekholm et al. | Oct 1988 | A |
| 4787389 | Tarjan | Nov 1988 | A |
| 4793353 | Borkan | Dec 1988 | A |
| 4819662 | Heil et al. | Apr 1989 | A |
| 4830006 | Haluska et al. | May 1989 | A |
| 4858610 | Callaghan et al. | Aug 1989 | A |
| 4865037 | Chin et al. | Sep 1989 | A |
| 4886064 | Strandberg | Dec 1989 | A |
| 4887609 | Cole, Jr. | Dec 1989 | A |
| 4928688 | Mower | May 1990 | A |
| 4953564 | Berthelsen | Sep 1990 | A |
| 4967746 | Vandegriff | Nov 1990 | A |
| 4987897 | Funke | Jan 1991 | A |
| 4989602 | Sholder et al. | Feb 1991 | A |
| 5012806 | De Bellis | May 1991 | A |
| 5036849 | Hauck et al. | Aug 1991 | A |
| 5040534 | Mann et al. | Aug 1991 | A |
| 5058581 | Silvian | Oct 1991 | A |
| 5078134 | Heilman et al. | Jan 1992 | A |
| 5107850 | Olive | Apr 1992 | A |
| 5109845 | Yuuchi et al. | May 1992 | A |
| 5113859 | Funke | May 1992 | A |
| 5113869 | Nappholz et al. | May 1992 | A |
| 5117824 | Keimel et al. | Jun 1992 | A |
| 5127401 | Grievous et al. | Jul 1992 | A |
| 5133353 | Hauser | Jul 1992 | A |
| 5144950 | Stoop et al. | Sep 1992 | A |
| 5154170 | Bennett et al. | Oct 1992 | A |
| 5170784 | Ramon et al. | Dec 1992 | A |
| 5174289 | Cohen | Dec 1992 | A |
| 5179945 | Van Hofwegen et al. | Jan 1993 | A |
| 5193539 | Schulman et al. | Mar 1993 | A |
| 5193540 | Schulman et al. | Mar 1993 | A |
| 5241961 | Henry | Sep 1993 | A |
| 5243977 | Trabucco et al. | Sep 1993 | A |
| 5255692 | Neubauer et al. | Oct 1993 | A |
| 5259387 | dePinto | Nov 1993 | A |
| 5269326 | Verrier | Dec 1993 | A |
| 5284136 | Hauck et al. | Feb 1994 | A |
| 5300107 | Stokes et al. | Apr 1994 | A |
| 5301677 | Hsung | Apr 1994 | A |
| 5305760 | McKown et al. | Apr 1994 | A |
| 5312439 | Loeb | May 1994 | A |
| 5313953 | Yomtov et al. | May 1994 | A |
| 5314459 | Swanson et al. | May 1994 | A |
| 5318594 | Limousin et al. | Jun 1994 | A |
| 5318597 | Hauck et al. | Jun 1994 | A |
| 5324316 | Schulman et al. | Jun 1994 | A |
| 5331966 | Bennett et al. | Jul 1994 | A |
| 5334222 | Salo et al. | Aug 1994 | A |
| 5342408 | Decoriolis et al. | Aug 1994 | A |
| 5370667 | Alt | Dec 1994 | A |
| 5372606 | Lang et al. | Dec 1994 | A |
| 5376106 | Stahmann et al. | Dec 1994 | A |
| 5383915 | Adams | Jan 1995 | A |
| 5388578 | Yomtov et al. | Feb 1995 | A |
| 5404877 | Nolan et al. | Apr 1995 | A |
| 5405367 | Schulman et al. | Apr 1995 | A |
| 5411031 | Yomtov | May 1995 | A |
| 5411525 | Swanson et al. | May 1995 | A |
| 5411535 | Fujii et al. | May 1995 | A |
| 5456691 | Snell | Oct 1995 | A |
| 5458622 | Alt | Oct 1995 | A |
| 5466246 | Silvian | Nov 1995 | A |
| 5468254 | Hahn et al. | Nov 1995 | A |
| 5472453 | Alt | Dec 1995 | A |
| 5496361 | Moberg | Mar 1996 | A |
| 5522866 | Fernald | Jun 1996 | A |
| 5540727 | Tockman et al. | Jul 1996 | A |
| 5545186 | Olson et al. | Aug 1996 | A |
| 5545202 | Dahl et al. | Aug 1996 | A |
| 5554177 | Kieval et al. | Sep 1996 | A |
| 5562711 | Yerich et al. | Oct 1996 | A |
| 5571146 | Jones et al. | Nov 1996 | A |
| 5591214 | Lu | Jan 1997 | A |
| 5620466 | Haefner et al. | Apr 1997 | A |
| 5634938 | Swanson et al. | Jun 1997 | A |
| 5649968 | Alt et al. | Jul 1997 | A |
| 5662688 | Haefner et al. | Sep 1997 | A |
| 5674259 | Gray | Oct 1997 | A |
| 5683426 | Greenhut et al. | Nov 1997 | A |
| 5683432 | Goedeke et al. | Nov 1997 | A |
| 5706823 | Wodlinger | Jan 1998 | A |
| 5709215 | Perttu et al. | Jan 1998 | A |
| 5720770 | Nappholz et al. | Feb 1998 | A |
| 5728140 | Salo et al. | Mar 1998 | A |
| 5728154 | Crossett et al. | Mar 1998 | A |
| 5741314 | Daly et al. | Apr 1998 | A |
| 5741315 | Lee et al. | Apr 1998 | A |
| 5749909 | Schroeppel et al. | May 1998 | A |
| 5752976 | Duffin et al. | May 1998 | A |
| 5752977 | Grievous et al. | May 1998 | A |
| 5755736 | Gillberg et al. | May 1998 | A |
| 5759199 | Snell et al. | Jun 1998 | A |
| 5774501 | Halpern et al. | Jun 1998 | A |
| 5792195 | Carlson et al. | Aug 1998 | A |
| 5792202 | Rueter | Aug 1998 | A |
| 5792203 | Schroeppel | Aug 1998 | A |
| 5792205 | Alt et al. | Aug 1998 | A |
| 5792208 | Gray | Aug 1998 | A |
| 5814089 | Stokes et al. | Sep 1998 | A |
| 5817130 | Cox et al. | Oct 1998 | A |
| 5827216 | Igo et al. | Oct 1998 | A |
| 5836985 | Goyal et al. | Nov 1998 | A |
| 5836987 | Baumann et al. | Nov 1998 | A |
| 5842977 | Lesho et al. | Dec 1998 | A |
| 5855593 | Olson et al. | Jan 1999 | A |
| 5873894 | Vandegriff et al. | Feb 1999 | A |
| 5891184 | Lee et al. | Apr 1999 | A |
| 5897586 | Molina | Apr 1999 | A |
| 5899876 | Flower | May 1999 | A |
| 5899928 | Sholder et al. | May 1999 | A |
| 5919214 | Ciciarelli et al. | Jul 1999 | A |
| 5928271 | Hess et al. | Jul 1999 | A |
| 5935078 | Feierbach | Aug 1999 | A |
| 5941906 | Barreras et al. | Aug 1999 | A |
| 5944744 | Paul et al. | Aug 1999 | A |
| 5954757 | Gray | Sep 1999 | A |
| 5978713 | Prutchi et al. | Nov 1999 | A |
| 5991660 | Goyal | Nov 1999 | A |
| 5991661 | Park et al. | Nov 1999 | A |
| 5999848 | Gord et al. | Dec 1999 | A |
| 5999857 | Weijand et al. | Dec 1999 | A |
| 6016445 | Baura | Jan 2000 | A |
| 6026320 | Carlson et al. | Feb 2000 | A |
| 6029085 | Olson et al. | Feb 2000 | A |
| 6041250 | dePinto | Mar 2000 | A |
| 6044298 | Salo et al. | Mar 2000 | A |
| 6044300 | Gray | Mar 2000 | A |
| 6055454 | Heemels | Apr 2000 | A |
| 6073050 | Griffith | Jun 2000 | A |
| 6076016 | Feierbach | Jun 2000 | A |
| 6077236 | Cunningham | Jun 2000 | A |
| 6080187 | Alt et al. | Jun 2000 | A |
| 6083248 | Thompson | Jul 2000 | A |
| 6106551 | Crossett et al. | Aug 2000 | A |
| 6115636 | Ryan | Sep 2000 | A |
| 6128526 | Stadler et al. | Oct 2000 | A |
| 6132456 | Sommer et al. | Oct 2000 | A |
| 6141581 | Olson et al. | Oct 2000 | A |
| 6141588 | Cox et al. | Oct 2000 | A |
| 6141592 | Pauly | Oct 2000 | A |
| 6144879 | Gray | Nov 2000 | A |
| 6162195 | Igo et al. | Dec 2000 | A |
| 6164284 | Schulman et al. | Dec 2000 | A |
| 6167310 | Grevious | Dec 2000 | A |
| 6201993 | Kruse et al. | Mar 2001 | B1 |
| 6208894 | Schulman et al. | Mar 2001 | B1 |
| 6211799 | Post et al. | Apr 2001 | B1 |
| 6221011 | Bardy | Apr 2001 | B1 |
| 6240316 | Richmond et al. | May 2001 | B1 |
| 6240317 | Villaseca et al. | May 2001 | B1 |
| 6256534 | Dahl | Jul 2001 | B1 |
| 6259947 | Olson et al. | Jul 2001 | B1 |
| 6266558 | Gozani et al. | Jul 2001 | B1 |
| 6266567 | Ishikawa et al. | Jul 2001 | B1 |
| 6270457 | Bardy | Aug 2001 | B1 |
| 6272377 | Sweeney et al. | Aug 2001 | B1 |
| 6273856 | Sun et al. | Aug 2001 | B1 |
| 6277072 | Bardy | Aug 2001 | B1 |
| 6280380 | Bardy | Aug 2001 | B1 |
| 6285903 | Rosenthal et al. | Sep 2001 | B1 |
| 6285907 | Kramer et al. | Sep 2001 | B1 |
| 6292698 | Duffin et al. | Sep 2001 | B1 |
| 6295473 | Rosar | Sep 2001 | B1 |
| 6297943 | Carson | Oct 2001 | B1 |
| 6298271 | Weijand | Oct 2001 | B1 |
| 6307751 | Bodony et al. | Oct 2001 | B1 |
| 6312378 | Bardy | Nov 2001 | B1 |
| 6315721 | Schulman et al. | Nov 2001 | B2 |
| 6336903 | Bardy | Jan 2002 | B1 |
| 6345202 | Richmond et al. | Feb 2002 | B2 |
| 6351667 | Godie | Feb 2002 | B1 |
| 6351669 | Hartley et al. | Feb 2002 | B1 |
| 6353759 | Hartley et al. | Mar 2002 | B1 |
| 6358203 | Bardy | Mar 2002 | B2 |
| 6361780 | Ley et al. | Mar 2002 | B1 |
| 6368284 | Bardy | Apr 2002 | B1 |
| 6371922 | Baumann et al. | Apr 2002 | B1 |
| 6393316 | Gillberg et al. | May 2002 | B1 |
| 6398728 | Bardy | Jun 2002 | B1 |
| 6400982 | Sweeney et al. | Jun 2002 | B2 |
| 6400990 | Silvian | Jun 2002 | B1 |
| 6408208 | Sun | Jun 2002 | B1 |
| 6409674 | Brockway et al. | Jun 2002 | B1 |
| 6411848 | Kramer et al. | Jun 2002 | B2 |
| 6424865 | Ding | Jul 2002 | B1 |
| 6434429 | Kraus et al. | Aug 2002 | B1 |
| 6438410 | Hsu et al. | Aug 2002 | B2 |
| 6438417 | Rockwell et al. | Aug 2002 | B1 |
| 6438421 | Stahmann et al. | Aug 2002 | B1 |
| 6440066 | Bardy | Aug 2002 | B1 |
| 6441747 | Khair et al. | Aug 2002 | B1 |
| 6442426 | Kroll | Aug 2002 | B1 |
| 6442432 | Lee | Aug 2002 | B2 |
| 6443891 | Grevious | Sep 2002 | B1 |
| 6445953 | Bulkes et al. | Sep 2002 | B1 |
| 6453200 | Koslar | Sep 2002 | B1 |
| 6459929 | Hopper et al. | Oct 2002 | B1 |
| 6470215 | Kraus et al. | Oct 2002 | B1 |
| 6471645 | Warkentin et al. | Oct 2002 | B1 |
| 6480745 | Nelson et al. | Nov 2002 | B2 |
| 6487443 | Olson et al. | Nov 2002 | B2 |
| 6490487 | Kraus et al. | Dec 2002 | B1 |
| 6498951 | Larson et al. | Dec 2002 | B1 |
| 6507755 | Gozani et al. | Jan 2003 | B1 |
| 6507759 | Prutchi et al. | Jan 2003 | B1 |
| 6508771 | Padmanabhan et al. | Jan 2003 | B1 |
| 6512940 | Brabec et al. | Jan 2003 | B1 |
| 6522915 | Ceballos et al. | Feb 2003 | B1 |
| 6526311 | Begemann | Feb 2003 | B2 |
| 6539253 | Thompson et al. | Mar 2003 | B2 |
| 6542775 | Ding et al. | Apr 2003 | B2 |
| 6544270 | Zhang | Apr 2003 | B1 |
| 6553258 | Stahmann et al. | Apr 2003 | B2 |
| 6561975 | Pool et al. | May 2003 | B1 |
| 6564807 | Schulman et al. | May 2003 | B1 |
| 6574506 | Kramer et al. | Jun 2003 | B2 |
| 6584351 | Ekwall | Jun 2003 | B1 |
| 6584352 | Combs et al. | Jun 2003 | B2 |
| 6597948 | Rockwell et al. | Jul 2003 | B1 |
| 6597951 | Kramer et al. | Jul 2003 | B2 |
| 6622046 | Fraley et al. | Sep 2003 | B2 |
| 6623518 | Thompson et al. | Sep 2003 | B2 |
| 6628985 | Sweeney et al. | Sep 2003 | B2 |
| 6647292 | Bardy et al. | Nov 2003 | B1 |
| 6666844 | Igo et al. | Dec 2003 | B1 |
| 6689117 | Sweeney et al. | Feb 2004 | B2 |
| 6690959 | Thompson | Feb 2004 | B2 |
| 6694189 | Begemann | Feb 2004 | B2 |
| 6704602 | Berg et al. | Mar 2004 | B2 |
| 6718212 | Parry et al. | Apr 2004 | B2 |
| 6721597 | Bardy et al. | Apr 2004 | B1 |
| 6738670 | Almendinger et al. | May 2004 | B1 |
| 6746797 | Benson et al. | Jun 2004 | B2 |
| 6749566 | Russ | Jun 2004 | B2 |
| 6754528 | Bardy et al. | Jun 2004 | B2 |
| 6758810 | Lebel et al. | Jul 2004 | B2 |
| 6763269 | Cox | Jul 2004 | B2 |
| 6778860 | Ostroff et al. | Aug 2004 | B2 |
| 6788971 | Sloman et al. | Sep 2004 | B1 |
| 6788974 | Bardy et al. | Sep 2004 | B2 |
| 6804558 | Haller et al. | Oct 2004 | B2 |
| 6807442 | Myklebust et al. | Oct 2004 | B1 |
| 6847844 | Sun et al. | Jan 2005 | B2 |
| 6869404 | Schulhauser et al. | Mar 2005 | B2 |
| 6871095 | Stahmann et al. | Mar 2005 | B2 |
| 6871096 | Hill | Mar 2005 | B2 |
| 6878112 | Linberg et al. | Apr 2005 | B2 |
| 6885889 | Chinchoy | Apr 2005 | B2 |
| 6892094 | Ousdigian et al. | May 2005 | B2 |
| 6897788 | Khair et al. | May 2005 | B2 |
| 6904315 | Panken et al. | Jun 2005 | B2 |
| 6922592 | Thompson et al. | Jul 2005 | B2 |
| 6931282 | Esler | Aug 2005 | B2 |
| 6931286 | Sigg et al. | Aug 2005 | B2 |
| 6934585 | Schloss et al. | Aug 2005 | B1 |
| 6941169 | Pappu | Sep 2005 | B2 |
| 6957107 | Rogers et al. | Oct 2005 | B2 |
| 6978176 | Lattouf | Dec 2005 | B2 |
| 6980675 | Evron et al. | Dec 2005 | B2 |
| 6985773 | Von Arx et al. | Jan 2006 | B2 |
| 6990375 | Kloss et al. | Jan 2006 | B2 |
| 6993389 | Ding et al. | Jan 2006 | B2 |
| 7001366 | Ballard | Feb 2006 | B2 |
| 7003350 | Denker et al. | Feb 2006 | B2 |
| 7006864 | Echt et al. | Feb 2006 | B2 |
| 7013176 | Ding et al. | Mar 2006 | B2 |
| 7013178 | Reinke et al. | Mar 2006 | B2 |
| 7027871 | Burnes et al. | Apr 2006 | B2 |
| 7031711 | Brown et al. | Apr 2006 | B2 |
| 7031771 | Brown et al. | Apr 2006 | B2 |
| 7035684 | Lee et al. | Apr 2006 | B2 |
| 7050849 | Echt et al. | May 2006 | B2 |
| 7060031 | Webb et al. | Jun 2006 | B2 |
| 7063693 | Guenst | Jun 2006 | B2 |
| 7082336 | Ransbury et al. | Jul 2006 | B2 |
| 7085606 | Flach et al. | Aug 2006 | B2 |
| 7092758 | Sun et al. | Aug 2006 | B2 |
| 7110824 | Amundson et al. | Sep 2006 | B2 |
| 7120504 | Osypka | Oct 2006 | B2 |
| 7130681 | Gebhardt et al. | Oct 2006 | B2 |
| 7139613 | Reinke et al. | Nov 2006 | B2 |
| 7142912 | Wagner et al. | Nov 2006 | B2 |
| 7146225 | Guenst et al. | Dec 2006 | B2 |
| 7146226 | Lau et al. | Dec 2006 | B2 |
| 7149581 | Goedeke | Dec 2006 | B2 |
| 7149588 | Lau et al. | Dec 2006 | B2 |
| 7158839 | Lau | Jan 2007 | B2 |
| 7162307 | Patrias | Jan 2007 | B2 |
| 7164952 | Lau et al. | Jan 2007 | B2 |
| 7177700 | Cox | Feb 2007 | B1 |
| 7181284 | Burnes et al. | Feb 2007 | B2 |
| 7181505 | Haller et al. | Feb 2007 | B2 |
| 7184830 | Echt et al. | Feb 2007 | B2 |
| 7186214 | Ness | Mar 2007 | B2 |
| 7191015 | Lamson et al. | Mar 2007 | B2 |
| 7200437 | Nabutovsky et al. | Apr 2007 | B1 |
| 7200439 | Zdeblick et al. | Apr 2007 | B2 |
| 7206423 | Feng et al. | Apr 2007 | B1 |
| 7209785 | Kim et al. | Apr 2007 | B2 |
| 7209790 | Thompson et al. | Apr 2007 | B2 |
| 7211884 | Davis et al. | May 2007 | B1 |
| 7212871 | Morgan | May 2007 | B1 |
| 7226440 | Gelfand et al. | Jun 2007 | B2 |
| 7228183 | Sun et al. | Jun 2007 | B2 |
| 7231248 | Kramer et al. | Jun 2007 | B2 |
| 7231253 | Tidemand et al. | Jun 2007 | B2 |
| 7236821 | Cates et al. | Jun 2007 | B2 |
| 7236829 | Farazi et al. | Jun 2007 | B1 |
| 7254448 | Almendinger et al. | Aug 2007 | B2 |
| 7260436 | Kilgore et al. | Aug 2007 | B2 |
| 7270669 | Sra | Sep 2007 | B1 |
| 7272448 | Morgan et al. | Sep 2007 | B1 |
| 7277755 | Falkenberg et al. | Oct 2007 | B1 |
| 7280872 | Mosesov et al. | Oct 2007 | B1 |
| 7286866 | Okerlund et al. | Oct 2007 | B2 |
| 7288096 | Chin | Oct 2007 | B2 |
| 7289847 | Gill et al. | Oct 2007 | B1 |
| 7289852 | Helfinstine et al. | Oct 2007 | B2 |
| 7289853 | Campbell et al. | Oct 2007 | B1 |
| 7289855 | Nghiem et al. | Oct 2007 | B2 |
| 7302294 | Kamath et al. | Nov 2007 | B2 |
| 7305266 | Kroll | Dec 2007 | B1 |
| 7307321 | Avanzino | Dec 2007 | B1 |
| 7308297 | Reddy et al. | Dec 2007 | B2 |
| 7308299 | Burrell et al. | Dec 2007 | B2 |
| 7310556 | Bulkes | Dec 2007 | B2 |
| 7317950 | Lee | Jan 2008 | B2 |
| 7319905 | Morgan et al. | Jan 2008 | B1 |
| 7321677 | Evron et al. | Jan 2008 | B2 |
| 7321798 | Muhlenberg et al. | Jan 2008 | B2 |
| 7333853 | Mazar et al. | Feb 2008 | B2 |
| 7336994 | Hettrick et al. | Feb 2008 | B2 |
| 7346381 | Okerlund et al. | Mar 2008 | B2 |
| 7346393 | Spinelli et al. | Mar 2008 | B2 |
| 7347819 | Lebel et al. | Mar 2008 | B2 |
| 7366572 | Heruth et al. | Apr 2008 | B2 |
| 7373207 | Lattouf | May 2008 | B2 |
| 7384403 | Sherman | Jun 2008 | B2 |
| 7386342 | Falkenberg et al. | Jun 2008 | B1 |
| 7392090 | Sweeney et al. | Jun 2008 | B2 |
| 7406105 | DelMain et al. | Jul 2008 | B2 |
| 7406349 | Seeberger et al. | Jul 2008 | B2 |
| 7410497 | Hastings et al. | Aug 2008 | B2 |
| 7425200 | Brockway et al. | Sep 2008 | B2 |
| 7433739 | Salys et al. | Oct 2008 | B1 |
| 7454248 | Burrell et al. | Nov 2008 | B2 |
| 7496409 | Greenhut et al. | Feb 2009 | B2 |
| 7496410 | Heil | Feb 2009 | B2 |
| 7499743 | Vass et al. | Mar 2009 | B2 |
| 7502652 | Gaunt et al. | Mar 2009 | B2 |
| 7512448 | Malick et al. | Mar 2009 | B2 |
| 7515969 | Tockman et al. | Apr 2009 | B2 |
| 7526342 | Chin et al. | Apr 2009 | B2 |
| 7529589 | Williams et al. | May 2009 | B2 |
| 7532933 | Hastings et al. | May 2009 | B2 |
| 7536222 | Bardy et al. | May 2009 | B2 |
| 7536224 | Ritscher et al. | May 2009 | B2 |
| 7539541 | Quiles et al. | May 2009 | B2 |
| 7544197 | Kelsch et al. | Jun 2009 | B2 |
| 7546166 | Michels et al. | Jun 2009 | B2 |
| 7558626 | Corbucci | Jul 2009 | B2 |
| 7558631 | Cowan et al. | Jul 2009 | B2 |
| 7565190 | Okerlund et al. | Jul 2009 | B2 |
| 7565195 | Kroll et al. | Jul 2009 | B1 |
| 7584002 | Burnes et al. | Sep 2009 | B2 |
| 7587074 | Zarkh et al. | Sep 2009 | B2 |
| 7590455 | Heruth et al. | Sep 2009 | B2 |
| 7599730 | Hunter et al. | Oct 2009 | B2 |
| 7606621 | Brisken et al. | Oct 2009 | B2 |
| 7610088 | Chinchoy | Oct 2009 | B2 |
| 7610092 | Cowan et al. | Oct 2009 | B2 |
| 7610099 | Almendinger et al. | Oct 2009 | B2 |
| 7610104 | Kaplan et al. | Oct 2009 | B2 |
| 7613500 | Vass et al. | Nov 2009 | B2 |
| 7616991 | Mann et al. | Nov 2009 | B2 |
| 7617001 | Penner et al. | Nov 2009 | B2 |
| 7617007 | Williams et al. | Nov 2009 | B2 |
| 7630764 | Ding et al. | Dec 2009 | B2 |
| 7630767 | Poore et al. | Dec 2009 | B1 |
| 7634313 | Kroll et al. | Dec 2009 | B1 |
| 7635541 | Scott et al. | Dec 2009 | B2 |
| 7637867 | Zdeblick | Dec 2009 | B2 |
| 7640057 | Libbus et al. | Dec 2009 | B2 |
| 7640060 | Zdeblick | Dec 2009 | B2 |
| 7647109 | Hastings et al. | Jan 2010 | B2 |
| 7650186 | Hastings et al. | Jan 2010 | B2 |
| 7657311 | Bardy et al. | Feb 2010 | B2 |
| 7657313 | Rom | Feb 2010 | B2 |
| 7668596 | Von Arx et al. | Feb 2010 | B2 |
| 7682316 | Anderson et al. | Mar 2010 | B2 |
| 7691047 | Ferrari | Apr 2010 | B2 |
| 7702392 | Echt et al. | Apr 2010 | B2 |
| 7706879 | Burnes et al. | Apr 2010 | B2 |
| 7713194 | Zdeblick | May 2010 | B2 |
| 7713195 | Zdeblick | May 2010 | B2 |
| 7729783 | Michels et al. | Jun 2010 | B2 |
| 7734333 | Ghanem et al. | Jun 2010 | B2 |
| 7734343 | Ransbury et al. | Jun 2010 | B2 |
| 7738958 | Zdeblick et al. | Jun 2010 | B2 |
| 7738964 | Von Arx et al. | Jun 2010 | B2 |
| 7742629 | Zarkh et al. | Jun 2010 | B2 |
| 7742812 | Ghanem et al. | Jun 2010 | B2 |
| 7742816 | Masoud et al. | Jun 2010 | B2 |
| 7742822 | Masoud et al. | Jun 2010 | B2 |
| 7743151 | Vallapureddy et al. | Jun 2010 | B2 |
| 7747047 | Okerlund et al. | Jun 2010 | B2 |
| 7747335 | Williams | Jun 2010 | B2 |
| 7751881 | Cowan et al. | Jul 2010 | B2 |
| 7758521 | Morris et al. | Jul 2010 | B2 |
| 7761150 | Ghanem et al. | Jul 2010 | B2 |
| 7761164 | Verhoef et al. | Jul 2010 | B2 |
| 7765001 | Echt et al. | Jul 2010 | B2 |
| 7769452 | Ghanem et al. | Aug 2010 | B2 |
| 7778685 | Evron et al. | Aug 2010 | B2 |
| 7778686 | Vass et al. | Aug 2010 | B2 |
| 7783362 | Whitehurst et al. | Aug 2010 | B2 |
| 7792588 | Harding | Sep 2010 | B2 |
| 7797059 | Bornzin et al. | Sep 2010 | B1 |
| 7801596 | Fischell et al. | Sep 2010 | B2 |
| 7809438 | Echt et al. | Oct 2010 | B2 |
| 7813785 | Okerlund et al. | Oct 2010 | B2 |
| 7840281 | Kveen et al. | Nov 2010 | B2 |
| 7844331 | Li et al. | Nov 2010 | B2 |
| 7844348 | Swoyer et al. | Nov 2010 | B2 |
| 7846088 | Ness | Dec 2010 | B2 |
| 7848815 | Brisken et al. | Dec 2010 | B2 |
| 7848823 | Drasler et al. | Dec 2010 | B2 |
| 7860455 | Fukumoto et al. | Dec 2010 | B2 |
| 7871433 | Lattouf | Jan 2011 | B2 |
| 7877136 | Moffitt et al. | Jan 2011 | B1 |
| 7877142 | Moaddeb et al. | Jan 2011 | B2 |
| 7877144 | Coles, Jr. et al. | Jan 2011 | B2 |
| 7881786 | Jackson | Feb 2011 | B2 |
| 7881791 | Sambelashvili et al. | Feb 2011 | B2 |
| 7881798 | Miesel et al. | Feb 2011 | B2 |
| 7881810 | Chitre et al. | Feb 2011 | B1 |
| 7890173 | Brisken et al. | Feb 2011 | B2 |
| 7890181 | Denzene et al. | Feb 2011 | B2 |
| 7890192 | Kelsch et al. | Feb 2011 | B1 |
| 7894885 | Bartal et al. | Feb 2011 | B2 |
| 7894894 | Stadler et al. | Feb 2011 | B2 |
| 7894902 | Rom | Feb 2011 | B2 |
| 7894907 | Cowan et al. | Feb 2011 | B2 |
| 7894910 | Cowan et al. | Feb 2011 | B2 |
| 7894915 | Chitre et al. | Feb 2011 | B1 |
| 7899537 | Kroll et al. | Mar 2011 | B1 |
| 7899541 | Cowan et al. | Mar 2011 | B2 |
| 7899542 | Cowan et al. | Mar 2011 | B2 |
| 7899554 | Williams et al. | Mar 2011 | B2 |
| 7901360 | Yang et al. | Mar 2011 | B1 |
| 7904170 | Harding | Mar 2011 | B2 |
| 7907993 | Ghanem et al. | Mar 2011 | B2 |
| 7912544 | Min et al. | Mar 2011 | B1 |
| 7920928 | Yang et al. | Apr 2011 | B1 |
| 7925343 | Min et al. | Apr 2011 | B1 |
| 7930022 | Zhang et al. | Apr 2011 | B2 |
| 7930027 | Prakash et al. | Apr 2011 | B2 |
| 7930040 | Kelsch et al. | Apr 2011 | B1 |
| 7937135 | Ghanem et al. | May 2011 | B2 |
| 7937148 | Jacobson | May 2011 | B2 |
| 7937161 | Hastings et al. | May 2011 | B2 |
| 7941214 | Kleckner et al. | May 2011 | B2 |
| 7941218 | Sambelashvili et al. | May 2011 | B2 |
| 7945333 | Jacobson | May 2011 | B2 |
| 7946997 | Hubinette | May 2011 | B2 |
| 7949404 | Hill | May 2011 | B2 |
| 7949405 | Feher | May 2011 | B2 |
| 7953486 | Daum et al. | May 2011 | B2 |
| 7953493 | Fowler et al. | May 2011 | B2 |
| 7962202 | Bhunia | Jun 2011 | B2 |
| 7974702 | Fain et al. | Jul 2011 | B1 |
| 7979136 | Young et al. | Jul 2011 | B2 |
| 7983753 | Severin | Jul 2011 | B2 |
| 7991467 | Markowitz et al. | Aug 2011 | B2 |
| 7991471 | Ghanem et al. | Aug 2011 | B2 |
| 7996063 | Vass et al. | Aug 2011 | B2 |
| 7996087 | Cowan et al. | Aug 2011 | B2 |
| 8000791 | Sunagawa et al. | Aug 2011 | B2 |
| 8000807 | Morris et al. | Aug 2011 | B2 |
| 8001975 | DiSilvestro et al. | Aug 2011 | B2 |
| 8002700 | Ferek-Petric et al. | Aug 2011 | B2 |
| 8002718 | Buchholtz et al. | Aug 2011 | B2 |
| 8010191 | Zhu et al. | Aug 2011 | B2 |
| 8010209 | Jacobson | Aug 2011 | B2 |
| 8014861 | Zhu et al. | Sep 2011 | B2 |
| 8019419 | Panescu et al. | Sep 2011 | B1 |
| 8019434 | Quiles et al. | Sep 2011 | B2 |
| 8027727 | Freeberg | Sep 2011 | B2 |
| 8027729 | Sunagawa et al. | Sep 2011 | B2 |
| 8032219 | Neumann et al. | Oct 2011 | B2 |
| 8036743 | Savage et al. | Oct 2011 | B2 |
| 8046065 | Burnes et al. | Oct 2011 | B2 |
| 8046079 | Bange et al. | Oct 2011 | B2 |
| 8046080 | Von Arx et al. | Oct 2011 | B2 |
| 8050297 | Delmain et al. | Nov 2011 | B2 |
| 8050759 | Stegemann et al. | Nov 2011 | B2 |
| 8050774 | Kveen et al. | Nov 2011 | B2 |
| 8055345 | Li et al. | Nov 2011 | B2 |
| 8055350 | Roberts | Nov 2011 | B2 |
| 8060185 | Hunter et al. | Nov 2011 | B2 |
| 8060212 | Rios et al. | Nov 2011 | B1 |
| 8065018 | Haubrich et al. | Nov 2011 | B2 |
| 8068920 | Gaudiani | Nov 2011 | B2 |
| 8073542 | Doerr | Dec 2011 | B2 |
| 8078278 | Penner | Dec 2011 | B2 |
| 8078283 | Cowan et al. | Dec 2011 | B2 |
| 8095123 | Gray | Jan 2012 | B2 |
| 8102789 | Rosar et al. | Jan 2012 | B2 |
| 8103359 | Reddy | Jan 2012 | B2 |
| 8103361 | Moser | Jan 2012 | B2 |
| 8105714 | Schmidt et al. | Jan 2012 | B2 |
| 8112148 | Giftakis et al. | Feb 2012 | B2 |
| 8114021 | Robertson et al. | Feb 2012 | B2 |
| 8121680 | Falkenberg et al. | Feb 2012 | B2 |
| 8123684 | Zdeblick | Feb 2012 | B2 |
| 8126545 | Flach et al. | Feb 2012 | B2 |
| 8131334 | Lu et al. | Mar 2012 | B2 |
| 8140161 | Willerton et al. | Mar 2012 | B2 |
| 8145308 | Sambelashvili et al. | Mar 2012 | B2 |
| 8150521 | Crowley et al. | Apr 2012 | B2 |
| 8160672 | Kim et al. | Apr 2012 | B2 |
| 8160702 | Mann et al. | Apr 2012 | B2 |
| 8160704 | Freeberg | Apr 2012 | B2 |
| 8165694 | Carbanaru et al. | Apr 2012 | B2 |
| 8175715 | Cox | May 2012 | B1 |
| 8180428 | Kaiser et al. | May 2012 | B2 |
| 8180451 | Hickman et al. | May 2012 | B2 |
| 8185213 | Kveen et al. | May 2012 | B2 |
| 8187161 | Li et al. | May 2012 | B2 |
| 8195293 | Limousin et al. | Jun 2012 | B2 |
| 8204590 | Sambelashvili et al. | Jun 2012 | B2 |
| 8204595 | Pianca et al. | Jun 2012 | B2 |
| 8204605 | Hastings et al. | Jun 2012 | B2 |
| 8209014 | Doerr | Jun 2012 | B2 |
| 8214041 | Van Gelder et al. | Jul 2012 | B2 |
| 8214043 | Matos | Jul 2012 | B2 |
| 8224244 | Kim et al. | Jul 2012 | B2 |
| 8229556 | Li | Jul 2012 | B2 |
| 8233985 | Bulkes et al. | Jul 2012 | B2 |
| 8262578 | Bharmi et al. | Sep 2012 | B1 |
| 8265748 | Liu et al. | Sep 2012 | B2 |
| 8265757 | Mass et al. | Sep 2012 | B2 |
| 8280521 | Haubrich et al. | Oct 2012 | B2 |
| 8285387 | Utsi et al. | Oct 2012 | B2 |
| 8290598 | Boon et al. | Oct 2012 | B2 |
| 8290600 | Hastings et al. | Oct 2012 | B2 |
| 8295939 | Jacobson | Oct 2012 | B2 |
| 8301254 | Mosesov et al. | Oct 2012 | B2 |
| 8315701 | Cowan et al. | Nov 2012 | B2 |
| 8315708 | Berthelsdorf et al. | Nov 2012 | B2 |
| 8321014 | Maskara et al. | Nov 2012 | B2 |
| 8321021 | Kisker et al. | Nov 2012 | B2 |
| 8321036 | Brockway et al. | Nov 2012 | B2 |
| 8332036 | Hastings et al. | Dec 2012 | B2 |
| 8335563 | Stessman | Dec 2012 | B2 |
| 8335568 | Heruth et al. | Dec 2012 | B2 |
| 8340750 | Prakash et al. | Dec 2012 | B2 |
| 8340780 | Hastings et al. | Dec 2012 | B2 |
| 8352025 | Jacobson | Jan 2013 | B2 |
| 8352027 | Spinelli et al. | Jan 2013 | B2 |
| 8352028 | Wenger | Jan 2013 | B2 |
| 8352038 | Mao et al. | Jan 2013 | B2 |
| 8359098 | Lund et al. | Jan 2013 | B2 |
| 8364261 | Stubbs et al. | Jan 2013 | B2 |
| 8364276 | Willis | Jan 2013 | B2 |
| 8369959 | Meskens | Feb 2013 | B2 |
| 8369962 | Abrahamson | Feb 2013 | B2 |
| 8380320 | Spital | Feb 2013 | B2 |
| 8383269 | Scott et al. | Feb 2013 | B2 |
| 8386051 | Rys | Feb 2013 | B2 |
| 8391964 | Musley et al. | Mar 2013 | B2 |
| 8391981 | Mosesov | Mar 2013 | B2 |
| 8391990 | Smith et al. | Mar 2013 | B2 |
| 8401616 | Verard et al. | Mar 2013 | B2 |
| 8406874 | Liu et al. | Mar 2013 | B2 |
| 8406879 | Shuros et al. | Mar 2013 | B2 |
| 8406886 | Gaunt et al. | Mar 2013 | B2 |
| 8406899 | Reddy et al. | Mar 2013 | B2 |
| 8412352 | Griswold et al. | Apr 2013 | B2 |
| 8417340 | Goossen | Apr 2013 | B2 |
| 8417341 | Freeberg | Apr 2013 | B2 |
| 8423149 | Hennig | Apr 2013 | B2 |
| 8428716 | Mullen et al. | Apr 2013 | B2 |
| 8428722 | Verhoef et al. | Apr 2013 | B2 |
| 8433402 | Ruben et al. | Apr 2013 | B2 |
| 8433409 | Johnson et al. | Apr 2013 | B2 |
| 8433420 | Bange et al. | Apr 2013 | B2 |
| 8447412 | Dal Molin et al. | May 2013 | B2 |
| 8452413 | Young et al. | May 2013 | B2 |
| 8457740 | Osche | Jun 2013 | B2 |
| 8457742 | Jacobson | Jun 2013 | B2 |
| 8457744 | Janzig et al. | Jun 2013 | B2 |
| 8457761 | Wariar | Jun 2013 | B2 |
| 8467871 | Maskara | Jun 2013 | B2 |
| 8478407 | Demmer et al. | Jul 2013 | B2 |
| 8478408 | Hastings et al. | Jul 2013 | B2 |
| 8478431 | Griswold et al. | Jul 2013 | B2 |
| 8494632 | Sun et al. | Jul 2013 | B2 |
| 8504156 | Bonner et al. | Aug 2013 | B2 |
| 8509910 | Sowder et al. | Aug 2013 | B2 |
| 8509916 | Byrd et al. | Aug 2013 | B2 |
| 8515559 | Roberts et al. | Aug 2013 | B2 |
| 8521268 | Zhang et al. | Aug 2013 | B2 |
| 8525340 | Eckhardt et al. | Sep 2013 | B2 |
| 8527068 | Ostroff | Sep 2013 | B2 |
| 8532790 | Griswold | Sep 2013 | B2 |
| 8538526 | Stahmann et al. | Sep 2013 | B2 |
| 8541131 | Lund | Sep 2013 | B2 |
| 8543205 | Ostroff | Sep 2013 | B2 |
| 8547248 | Zdeblick et al. | Oct 2013 | B2 |
| 8548605 | Ollivier | Oct 2013 | B2 |
| 8554333 | Wu et al. | Oct 2013 | B2 |
| 8565882 | Matoes | Oct 2013 | B2 |
| 8565897 | Regnier et al. | Oct 2013 | B2 |
| 8571678 | Wang | Oct 2013 | B2 |
| 8577327 | Makdissi et al. | Nov 2013 | B2 |
| 8588926 | Moore et al. | Nov 2013 | B2 |
| 8594775 | Ghosh et al. | Nov 2013 | B2 |
| 8612002 | Faltys et al. | Dec 2013 | B2 |
| 8615310 | Khairkhahan et al. | Dec 2013 | B2 |
| 8617082 | Zhang et al. | Dec 2013 | B2 |
| 8626280 | Allavatam et al. | Jan 2014 | B2 |
| 8626294 | Sheldon et al. | Jan 2014 | B2 |
| 8634908 | Cowan | Jan 2014 | B2 |
| 8634912 | Bornzin et al. | Jan 2014 | B2 |
| 8634919 | Hou et al. | Jan 2014 | B1 |
| 8639333 | Stadler et al. | Jan 2014 | B2 |
| 8639335 | Peichel et al. | Jan 2014 | B2 |
| 8644934 | Hastings et al. | Feb 2014 | B2 |
| 8649859 | Smith et al. | Feb 2014 | B2 |
| 8670842 | Bornzin et al. | Mar 2014 | B1 |
| 8676314 | Maskara et al. | Mar 2014 | B2 |
| 8676319 | Knoll | Mar 2014 | B2 |
| 8676335 | Katoozi et al. | Mar 2014 | B2 |
| 8700173 | Edlund | Apr 2014 | B2 |
| 8700181 | Bornzin et al. | Apr 2014 | B2 |
| 8705599 | Dal Molin et al. | Apr 2014 | B2 |
| 8718766 | Wahlberg | May 2014 | B2 |
| 8718773 | Willis et al. | May 2014 | B2 |
| 8725260 | Shuros et al. | May 2014 | B2 |
| 8731642 | Zarkh et al. | May 2014 | B2 |
| 8738133 | Shuros et al. | May 2014 | B2 |
| 8738147 | Hastings et al. | May 2014 | B2 |
| 8744555 | Allavatam et al. | Jun 2014 | B2 |
| 8744572 | Greenhut et al. | Jun 2014 | B1 |
| 8747314 | Stahmann et al. | Jun 2014 | B2 |
| 8750994 | Ghosh et al. | Jun 2014 | B2 |
| 8750998 | Ghosh et al. | Jun 2014 | B1 |
| 8755884 | Demmer et al. | Jun 2014 | B2 |
| 8758365 | Bonner et al. | Jun 2014 | B2 |
| 8768459 | Ghosh et al. | Jul 2014 | B2 |
| 8768483 | Schmitt et al. | Jul 2014 | B2 |
| 8774572 | Hamamoto | Jul 2014 | B2 |
| 8781605 | Bornzin et al. | Jul 2014 | B2 |
| 8788035 | Jacobson | Jul 2014 | B2 |
| 8788053 | Jacobson | Jul 2014 | B2 |
| 8798740 | Samade et al. | Aug 2014 | B2 |
| 8798745 | Jacobson | Aug 2014 | B2 |
| 8798762 | Fain et al. | Aug 2014 | B2 |
| 8798770 | Reddy | Aug 2014 | B2 |
| 8805505 | Roberts | Aug 2014 | B1 |
| 8805528 | Corndorf | Aug 2014 | B2 |
| 8812109 | Blomqvist et al. | Aug 2014 | B2 |
| 8818504 | Bodner et al. | Aug 2014 | B2 |
| 8827913 | Havel et al. | Sep 2014 | B2 |
| 8831747 | Min et al. | Sep 2014 | B1 |
| 8855789 | Jacobson | Oct 2014 | B2 |
| 8861830 | Brada et al. | Oct 2014 | B2 |
| 8868186 | Kroll | Oct 2014 | B2 |
| 8886307 | Sambelashvili et al. | Nov 2014 | B2 |
| 8886311 | Anderson et al. | Nov 2014 | B2 |
| 8886339 | Faltys et al. | Nov 2014 | B2 |
| 8903473 | Rogers et al. | Dec 2014 | B2 |
| 8903513 | Ollivier | Dec 2014 | B2 |
| 8909336 | Navarro-Paredes et al. | Dec 2014 | B2 |
| 8914131 | Bornzin et al. | Dec 2014 | B2 |
| 8923795 | Makdissi et al. | Dec 2014 | B2 |
| 8923963 | Bonner et al. | Dec 2014 | B2 |
| 8938300 | Rosero | Jan 2015 | B2 |
| 8942806 | Sheldon et al. | Jan 2015 | B2 |
| 8948883 | Eggen et al. | Feb 2015 | B2 |
| 8958892 | Khairkhahan et al. | Feb 2015 | B2 |
| 8977358 | Ewert et al. | Mar 2015 | B2 |
| 8989873 | Locsin | Mar 2015 | B2 |
| 8996109 | Karst et al. | Mar 2015 | B2 |
| 9002467 | Smith et al. | Apr 2015 | B2 |
| 9008776 | Cowan et al. | Apr 2015 | B2 |
| 9008777 | Dianaty et al. | Apr 2015 | B2 |
| 9014818 | Deterre et al. | Apr 2015 | B2 |
| 9017341 | Bornzin et al. | Apr 2015 | B2 |
| 9020611 | Khairkhahan et al. | Apr 2015 | B2 |
| 9033996 | West | May 2015 | B1 |
| 9037262 | Regnier et al. | May 2015 | B2 |
| 9042984 | Demmer et al. | May 2015 | B2 |
| 9072872 | Asleson et al. | Jul 2015 | B2 |
| 9072911 | Hastings et al. | Jul 2015 | B2 |
| 9072913 | Jacobson | Jul 2015 | B2 |
| 9101281 | Reinert et al. | Aug 2015 | B2 |
| 9119959 | Rys et al. | Sep 2015 | B2 |
| 9155882 | Grubac et al. | Oct 2015 | B2 |
| 9168372 | Fain | Oct 2015 | B2 |
| 9168380 | Greenhut et al. | Oct 2015 | B1 |
| 9168383 | Jacobson et al. | Oct 2015 | B2 |
| 9180285 | Moore et al. | Nov 2015 | B2 |
| 9192774 | Jacobson | Nov 2015 | B2 |
| 9205225 | Khairkhahan et al. | Dec 2015 | B2 |
| 9216285 | Boling et al. | Dec 2015 | B1 |
| 9216293 | Berthiaume et al. | Dec 2015 | B2 |
| 9216298 | Jacobson | Dec 2015 | B2 |
| 9227077 | Jacobson | Jan 2016 | B2 |
| 9238145 | Wenzel et al. | Jan 2016 | B2 |
| 9242102 | Khairkhahan et al. | Jan 2016 | B2 |
| 9242113 | Smith et al. | Jan 2016 | B2 |
| 9248300 | Rys et al. | Feb 2016 | B2 |
| 9265436 | Min et al. | Feb 2016 | B2 |
| 9265962 | Dianaty et al. | Feb 2016 | B2 |
| 9272155 | Ostroff | Mar 2016 | B2 |
| 9278218 | Karst et al. | Mar 2016 | B2 |
| 9278229 | Reinke et al. | Mar 2016 | B1 |
| 9283381 | Grubac et al. | Mar 2016 | B2 |
| 9283382 | Berthiaume et al. | Mar 2016 | B2 |
| 9289612 | Sambelashbili et al. | Mar 2016 | B1 |
| 9302115 | Molin et al. | Apr 2016 | B2 |
| 9320446 | Gillberg et al. | Apr 2016 | B2 |
| 9333364 | Echt et al. | May 2016 | B2 |
| 9358387 | Suwito et al. | Jun 2016 | B2 |
| 9358400 | Jacobson | Jun 2016 | B2 |
| 9364675 | Deterre et al. | Jun 2016 | B2 |
| 9370663 | Moulder | Jun 2016 | B2 |
| 9375580 | Bonner et al. | Jun 2016 | B2 |
| 9375581 | Baru et al. | Jun 2016 | B2 |
| 9381365 | Kibler et al. | Jul 2016 | B2 |
| 9393424 | Demmer et al. | Jul 2016 | B2 |
| 9393436 | Doerr | Jul 2016 | B2 |
| 9399139 | Demmer et al. | Jul 2016 | B2 |
| 9399140 | Cho et al. | Jul 2016 | B2 |
| 9409033 | Jacobson | Aug 2016 | B2 |
| 9427594 | Bornzin et al. | Aug 2016 | B1 |
| 9433368 | Stahmann et al. | Sep 2016 | B2 |
| 9433780 | Regnier et al. | Sep 2016 | B2 |
| 9457193 | Klimovitch et al. | Oct 2016 | B2 |
| 9474457 | Ghosh et al. | Oct 2016 | B2 |
| 9486151 | Ghosh et al. | Nov 2016 | B2 |
| 9492668 | Sheldon et al. | Nov 2016 | B2 |
| 9492669 | Demmer et al. | Nov 2016 | B2 |
| 9492674 | Schmidt et al. | Nov 2016 | B2 |
| 9492677 | Greenhut et al. | Nov 2016 | B2 |
| 9511233 | Sambelashvili | Dec 2016 | B2 |
| 9511236 | Varady et al. | Dec 2016 | B2 |
| 9511237 | Deterre et al. | Dec 2016 | B2 |
| 9517336 | Eggen et al. | Dec 2016 | B2 |
| 9522276 | Shen et al. | Dec 2016 | B2 |
| 9522280 | Fishler et al. | Dec 2016 | B2 |
| 9526522 | Wood et al. | Dec 2016 | B2 |
| 9526891 | Eggen et al. | Dec 2016 | B2 |
| 9526909 | Stahmann et al. | Dec 2016 | B2 |
| 9533163 | Klimovitch et al. | Jan 2017 | B2 |
| 9561382 | Persson et al. | Feb 2017 | B2 |
| 9566012 | Greenhut et al. | Feb 2017 | B2 |
| 9579500 | Rys et al. | Feb 2017 | B2 |
| 9623234 | Anderson | Apr 2017 | B2 |
| 9636511 | Carney et al. | May 2017 | B2 |
| 9643014 | Zhang et al. | May 2017 | B2 |
| 9675579 | Rock et al. | Jun 2017 | B2 |
| 9707399 | Zielinski et al. | Jul 2017 | B2 |
| 9724519 | Demmer et al. | Aug 2017 | B2 |
| 9789319 | Sambelashvili | Oct 2017 | B2 |
| 9808628 | Sheldon et al. | Nov 2017 | B2 |
| 9808633 | Bonner et al. | Nov 2017 | B2 |
| 9877789 | Ghosh | Jan 2018 | B2 |
| 9924884 | Ghosh et al. | Mar 2018 | B2 |
| 10004467 | Lahm et al. | Jun 2018 | B2 |
| 10064567 | Ghosh et al. | Sep 2018 | B2 |
| 10099050 | Chen et al. | Oct 2018 | B2 |
| 10166396 | Schrock et al. | Jan 2019 | B2 |
| 10251555 | Ghosh et al. | Apr 2019 | B2 |
| 11235159 | Yang et al. | Feb 2022 | B2 |
| 20020032470 | Linberg | Mar 2002 | A1 |
| 20020035376 | Bardy et al. | Mar 2002 | A1 |
| 20020035377 | Bardy et al. | Mar 2002 | A1 |
| 20020035378 | Bardy et al. | Mar 2002 | A1 |
| 20020035380 | Rissmann et al. | Mar 2002 | A1 |
| 20020035381 | Bardy et al. | Mar 2002 | A1 |
| 20020042629 | Bardy et al. | Apr 2002 | A1 |
| 20020042630 | Bardy et al. | Apr 2002 | A1 |
| 20020042634 | Bardy et al. | Apr 2002 | A1 |
| 20020049475 | Bardy et al. | Apr 2002 | A1 |
| 20020049476 | Bardy et al. | Apr 2002 | A1 |
| 20020052636 | Bardy et al. | May 2002 | A1 |
| 20020068958 | Bardy et al. | Jun 2002 | A1 |
| 20020072773 | Bardy et al. | Jun 2002 | A1 |
| 20020082652 | Wentkowski et al. | Jun 2002 | A1 |
| 20020082665 | Haller et al. | Jun 2002 | A1 |
| 20020091414 | Bardy et al. | Jul 2002 | A1 |
| 20020095196 | Linberg | Jul 2002 | A1 |
| 20020099423 | Berg et al. | Jul 2002 | A1 |
| 20020103510 | Bardy et al. | Aug 2002 | A1 |
| 20020107545 | Rissmann et al. | Aug 2002 | A1 |
| 20020107546 | Ostroff et al. | Aug 2002 | A1 |
| 20020107547 | Erlinger et al. | Aug 2002 | A1 |
| 20020107548 | Bardy et al. | Aug 2002 | A1 |
| 20020107549 | Bardy et al. | Aug 2002 | A1 |
| 20020107559 | Sanders et al. | Aug 2002 | A1 |
| 20020120299 | Ostroff et al. | Aug 2002 | A1 |
| 20020173830 | Starkweather et al. | Nov 2002 | A1 |
| 20020193846 | Pool et al. | Dec 2002 | A1 |
| 20030004549 | Hill et al. | Jan 2003 | A1 |
| 20030009203 | Lebel et al. | Jan 2003 | A1 |
| 20030028082 | Thompson | Feb 2003 | A1 |
| 20030040779 | Engmark et al. | Feb 2003 | A1 |
| 20030041866 | Linberg et al. | Mar 2003 | A1 |
| 20030045805 | Sheldon et al. | Mar 2003 | A1 |
| 20030088278 | Bardy et al. | May 2003 | A1 |
| 20030092995 | Thompson | May 2003 | A1 |
| 20030093122 | Vanhout | May 2003 | A1 |
| 20030097153 | Bardy et al. | May 2003 | A1 |
| 20030105497 | Zhu et al. | Jun 2003 | A1 |
| 20030114908 | Flach | Jun 2003 | A1 |
| 20030144701 | Mehra et al. | Jul 2003 | A1 |
| 20030187460 | Chin et al. | Oct 2003 | A1 |
| 20030187461 | Chin | Oct 2003 | A1 |
| 20040024435 | Leckrone et al. | Feb 2004 | A1 |
| 20040064158 | Klein et al. | Apr 2004 | A1 |
| 20040068302 | Rodgers et al. | Apr 2004 | A1 |
| 20040087938 | Leckrone et al. | May 2004 | A1 |
| 20040088035 | Guenst et al. | May 2004 | A1 |
| 20040102830 | Williams | May 2004 | A1 |
| 20040127959 | Amundson et al. | Jul 2004 | A1 |
| 20040133242 | Chapman et al. | Jul 2004 | A1 |
| 20040147969 | Mann et al. | Jul 2004 | A1 |
| 20040147973 | Hauser | Jul 2004 | A1 |
| 20040167558 | Igo et al. | Aug 2004 | A1 |
| 20040167587 | Thompson | Aug 2004 | A1 |
| 20040172071 | Bardy et al. | Sep 2004 | A1 |
| 20040172077 | Chinchoy | Sep 2004 | A1 |
| 20040172104 | Berg et al. | Sep 2004 | A1 |
| 20040176817 | Wahlstrand et al. | Sep 2004 | A1 |
| 20040176818 | Wahlstrand et al. | Sep 2004 | A1 |
| 20040176830 | Fang | Sep 2004 | A1 |
| 20040186529 | Bardy et al. | Sep 2004 | A1 |
| 20040204673 | Flaherty | Oct 2004 | A1 |
| 20040210292 | Bardy et al. | Oct 2004 | A1 |
| 20040210293 | Bardy et al. | Oct 2004 | A1 |
| 20040210294 | Bardy et al. | Oct 2004 | A1 |
| 20040215308 | Bardy et al. | Oct 2004 | A1 |
| 20040220624 | Ritscher et al. | Nov 2004 | A1 |
| 20040220626 | Wagner | Nov 2004 | A1 |
| 20040220639 | Mulligan et al. | Nov 2004 | A1 |
| 20040230283 | Prinzen et al. | Dec 2004 | A1 |
| 20040249431 | Ransbury et al. | Dec 2004 | A1 |
| 20040260348 | Bakken et al. | Dec 2004 | A1 |
| 20040267303 | Guenst | Dec 2004 | A1 |
| 20050008210 | Evron et al. | Jan 2005 | A1 |
| 20050038477 | Kramer et al. | Feb 2005 | A1 |
| 20050061320 | Lee et al. | Mar 2005 | A1 |
| 20050070962 | Echt et al. | Mar 2005 | A1 |
| 20050102003 | Grabek et al. | May 2005 | A1 |
| 20050137629 | Dyjach et al. | Jun 2005 | A1 |
| 20050137671 | Liu et al. | Jun 2005 | A1 |
| 20050149138 | Min et al. | Jul 2005 | A1 |
| 20050165466 | Morris et al. | Jul 2005 | A1 |
| 20050182465 | Ness | Aug 2005 | A1 |
| 20050203410 | Jenkins | Sep 2005 | A1 |
| 20050277990 | Ostroff et al. | Dec 2005 | A1 |
| 20050283208 | Von Arx et al. | Dec 2005 | A1 |
| 20050288720 | Ross | Dec 2005 | A1 |
| 20050288743 | Ahn et al. | Dec 2005 | A1 |
| 20060042830 | Maghribi et al. | Mar 2006 | A1 |
| 20060052829 | Sun et al. | Mar 2006 | A1 |
| 20060052830 | Spinelli et al. | Mar 2006 | A1 |
| 20060064135 | Brockway | Mar 2006 | A1 |
| 20060064149 | Belacazar et al. | Mar 2006 | A1 |
| 20060074285 | Zarkh et al. | Apr 2006 | A1 |
| 20060085039 | Hastings et al. | Apr 2006 | A1 |
| 20060085041 | Hastings et al. | Apr 2006 | A1 |
| 20060085042 | Hastings et al. | Apr 2006 | A1 |
| 20060095078 | Tronnes | May 2006 | A1 |
| 20060106442 | Richardson et al. | May 2006 | A1 |
| 20060116746 | Chin | Jun 2006 | A1 |
| 20060135999 | Bodner et al. | Jun 2006 | A1 |
| 20060136004 | Cowan et al. | Jun 2006 | A1 |
| 20060161061 | Echt et al. | Jul 2006 | A1 |
| 20060161205 | Mitrani et al. | Jul 2006 | A1 |
| 20060200002 | Guenst | Sep 2006 | A1 |
| 20060206151 | Lu | Sep 2006 | A1 |
| 20060212079 | Routh et al. | Sep 2006 | A1 |
| 20060235478 | Van Gelder et al. | Oct 2006 | A1 |
| 20060241701 | Markowitz et al. | Oct 2006 | A1 |
| 20060241705 | Neumann et al. | Oct 2006 | A1 |
| 20060247672 | Vidlund et al. | Nov 2006 | A1 |
| 20060259088 | Pastore et al. | Nov 2006 | A1 |
| 20060265018 | Smith et al. | Nov 2006 | A1 |
| 20070004979 | Wojciechowicz et al. | Jan 2007 | A1 |
| 20070016098 | Kim et al. | Jan 2007 | A1 |
| 20070027508 | Cowan | Feb 2007 | A1 |
| 20070049975 | Cates et al. | Mar 2007 | A1 |
| 20070078490 | Cowan et al. | Apr 2007 | A1 |
| 20070088394 | Jacobson | Apr 2007 | A1 |
| 20070088396 | Jacobson | Apr 2007 | A1 |
| 20070088397 | Jacobson | Apr 2007 | A1 |
| 20070088398 | Jacobson | Apr 2007 | A1 |
| 20070088405 | Jaconson | Apr 2007 | A1 |
| 20070135882 | Drasler et al. | Jun 2007 | A1 |
| 20070135883 | Drasler et al. | Jun 2007 | A1 |
| 20070150037 | Hastings et al. | Jun 2007 | A1 |
| 20070150038 | Hastings et al. | Jun 2007 | A1 |
| 20070156190 | Cinbis | Jul 2007 | A1 |
| 20070219525 | Gelfand et al. | Sep 2007 | A1 |
| 20070219590 | Hastings et al. | Sep 2007 | A1 |
| 20070225545 | Ferrari | Sep 2007 | A1 |
| 20070233206 | Frikart et al. | Oct 2007 | A1 |
| 20070233216 | Liu et al. | Oct 2007 | A1 |
| 20070239244 | Morgan et al. | Oct 2007 | A1 |
| 20070255376 | Michels et al. | Nov 2007 | A1 |
| 20070276444 | Gelbart et al. | Nov 2007 | A1 |
| 20070293900 | Sheldon et al. | Dec 2007 | A1 |
| 20070293904 | Gelbart et al. | Dec 2007 | A1 |
| 20070299475 | Levin et al. | Dec 2007 | A1 |
| 20080004663 | Jorgenson | Jan 2008 | A1 |
| 20080021505 | Hastings et al. | Jan 2008 | A1 |
| 20080021519 | De Geest et al. | Jan 2008 | A1 |
| 20080021532 | Kveen et al. | Jan 2008 | A1 |
| 20080065183 | Whitehurst et al. | Mar 2008 | A1 |
| 20080065185 | Worley | Mar 2008 | A1 |
| 20080071318 | Brooke et al. | Mar 2008 | A1 |
| 20080109054 | Hastings et al. | May 2008 | A1 |
| 20080119911 | Rosero | May 2008 | A1 |
| 20080130670 | Kim et al. | Jun 2008 | A1 |
| 20080154139 | Shuros et al. | Jun 2008 | A1 |
| 20080154322 | Jackson et al. | Jun 2008 | A1 |
| 20080228234 | Stancer | Sep 2008 | A1 |
| 20080234771 | Chinchoy et al. | Sep 2008 | A1 |
| 20080243217 | Wildon | Oct 2008 | A1 |
| 20080269814 | Rosero | Oct 2008 | A1 |
| 20080269816 | Prakash et al. | Oct 2008 | A1 |
| 20080269823 | Burnes et al. | Oct 2008 | A1 |
| 20080269825 | Chinchoy et al. | Oct 2008 | A1 |
| 20080275518 | Ghanem et al. | Nov 2008 | A1 |
| 20080275519 | Ghanem et al. | Nov 2008 | A1 |
| 20080288039 | Reddy | Nov 2008 | A1 |
| 20080294208 | Willis et al. | Nov 2008 | A1 |
| 20080294210 | Rosero | Nov 2008 | A1 |
| 20080294229 | Friedman et al. | Nov 2008 | A1 |
| 20080306359 | Zdeblick et al. | Dec 2008 | A1 |
| 20090018599 | Hastings et al. | Jan 2009 | A1 |
| 20090024180 | Kisker et al. | Jan 2009 | A1 |
| 20090036941 | Corbucci | Feb 2009 | A1 |
| 20090048646 | Katoozi et al. | Feb 2009 | A1 |
| 20090062895 | Stahmann et al. | Mar 2009 | A1 |
| 20090082827 | Kveen et al. | Mar 2009 | A1 |
| 20090082828 | Ostroff | Mar 2009 | A1 |
| 20090088813 | Brockway et al. | Apr 2009 | A1 |
| 20090099619 | Lessmeier et al. | Apr 2009 | A1 |
| 20090131907 | Chin et al. | May 2009 | A1 |
| 20090135886 | Robertson et al. | May 2009 | A1 |
| 20090143835 | Pastore et al. | Jun 2009 | A1 |
| 20090171408 | Solem | Jul 2009 | A1 |
| 20090171414 | Kelly et al. | Jul 2009 | A1 |
| 20090204163 | Shuros et al. | Aug 2009 | A1 |
| 20090204170 | Hastings et al. | Aug 2009 | A1 |
| 20090210024 | Jason | Aug 2009 | A1 |
| 20090216292 | Pless et al. | Aug 2009 | A1 |
| 20090234407 | Hastings et al. | Sep 2009 | A1 |
| 20090234411 | Sambelashvili et al. | Sep 2009 | A1 |
| 20090234412 | Sambelashvili | Sep 2009 | A1 |
| 20090234413 | Sambelashvili et al. | Sep 2009 | A1 |
| 20090234414 | Sambelashvili et al. | Sep 2009 | A1 |
| 20090234415 | Sambelashvili et al. | Sep 2009 | A1 |
| 20090248103 | Sambelashvili et al. | Oct 2009 | A1 |
| 20090266573 | Engmark et al. | Oct 2009 | A1 |
| 20090275998 | Burnes et al. | Nov 2009 | A1 |
| 20090275999 | Burnes et al. | Nov 2009 | A1 |
| 20090299447 | Jensen et al. | Dec 2009 | A1 |
| 20100013668 | Kantervik | Jan 2010 | A1 |
| 20100016911 | Willis et al. | Jan 2010 | A1 |
| 20100016914 | Mullen et al. | Jan 2010 | A1 |
| 20100023078 | Dong et al. | Jan 2010 | A1 |
| 20100023085 | Wu et al. | Jan 2010 | A1 |
| 20100030061 | Canfield et al. | Feb 2010 | A1 |
| 20100030327 | Chatel | Feb 2010 | A1 |
| 20100042108 | Hibino | Feb 2010 | A1 |
| 20100063375 | Kassab et al. | Mar 2010 | A1 |
| 20100063562 | Cowan et al. | Mar 2010 | A1 |
| 20100065871 | Govari et al. | Mar 2010 | A1 |
| 20100094367 | Sen | Apr 2010 | A1 |
| 20100114209 | Krause et al. | May 2010 | A1 |
| 20100114214 | Morelli et al. | May 2010 | A1 |
| 20100125281 | Jacobson et al. | May 2010 | A1 |
| 20100152798 | Sanghera et al. | Jun 2010 | A1 |
| 20100168761 | Kassab et al. | Jul 2010 | A1 |
| 20100168819 | Freeberg | Jul 2010 | A1 |
| 20100185250 | Rom | Jul 2010 | A1 |
| 20100198288 | Ostroff | Aug 2010 | A1 |
| 20100198291 | Sambelashvili et al. | Aug 2010 | A1 |
| 20100198304 | Wang | Aug 2010 | A1 |
| 20100217367 | Belson | Aug 2010 | A1 |
| 20100218147 | Ishikawa | Aug 2010 | A1 |
| 20100228308 | Cowan et al. | Sep 2010 | A1 |
| 20100234906 | Koh | Sep 2010 | A1 |
| 20100234924 | Willis | Sep 2010 | A1 |
| 20100241185 | Mahapatra et al. | Sep 2010 | A1 |
| 20100249729 | Morris et al. | Sep 2010 | A1 |
| 20100286541 | Musley et al. | Nov 2010 | A1 |
| 20100286626 | Petersen | Nov 2010 | A1 |
| 20100286744 | Echt et al. | Nov 2010 | A1 |
| 20100298841 | Prinzen et al. | Nov 2010 | A1 |
| 20100312309 | Harding | Dec 2010 | A1 |
| 20110022113 | Zdeblick et al. | Jan 2011 | A1 |
| 20110071586 | Jacobson | Mar 2011 | A1 |
| 20110077708 | Ostroff | Mar 2011 | A1 |
| 20110106202 | Ding et al. | May 2011 | A1 |
| 20110112398 | Zarkh et al. | May 2011 | A1 |
| 20110112600 | Cowan et al. | May 2011 | A1 |
| 20110118588 | Komblau et al. | May 2011 | A1 |
| 20110118810 | Cowan et al. | May 2011 | A1 |
| 20110137187 | Yang et al. | Jun 2011 | A1 |
| 20110144720 | Cowan et al. | Jun 2011 | A1 |
| 20110152970 | Jollota et al. | Jun 2011 | A1 |
| 20110160558 | Rassatt et al. | Jun 2011 | A1 |
| 20110160565 | Stubbs | Jun 2011 | A1 |
| 20110160801 | Markowitz et al. | Jun 2011 | A1 |
| 20110160806 | Lyden et al. | Jun 2011 | A1 |
| 20110166620 | Cowan et al. | Jul 2011 | A1 |
| 20110166621 | Cowan et al. | Jul 2011 | A1 |
| 20110184491 | Kivi | Jul 2011 | A1 |
| 20110190835 | Brockway et al. | Aug 2011 | A1 |
| 20110190841 | Sambelashvili et al. | Aug 2011 | A1 |
| 20110196444 | Prakash et al. | Aug 2011 | A1 |
| 20110208260 | Jacobson | Aug 2011 | A1 |
| 20110218587 | Jacobson | Sep 2011 | A1 |
| 20110230734 | Fain et al. | Sep 2011 | A1 |
| 20110237967 | Moore et al. | Sep 2011 | A1 |
| 20110245890 | Brisben et al. | Oct 2011 | A1 |
| 20110251660 | Griswold | Oct 2011 | A1 |
| 20110251662 | Griswold et al. | Oct 2011 | A1 |
| 20110270099 | Ruben et al. | Nov 2011 | A1 |
| 20110270339 | Murray, III et al. | Nov 2011 | A1 |
| 20110270340 | Pellegrini et al. | Nov 2011 | A1 |
| 20110276102 | Cohen | Nov 2011 | A1 |
| 20110282423 | Jacobson | Nov 2011 | A1 |
| 20120004527 | Thompson et al. | Jan 2012 | A1 |
| 20120029323 | Zhao | Feb 2012 | A1 |
| 20120035685 | Saha et al. | Feb 2012 | A1 |
| 20120041508 | Rousso et al. | Feb 2012 | A1 |
| 20120059433 | Cowan et al. | Mar 2012 | A1 |
| 20120059436 | Fontaine et al. | Mar 2012 | A1 |
| 20120065500 | Rogers et al. | Mar 2012 | A1 |
| 20120078322 | Dal Molin et al. | Mar 2012 | A1 |
| 20120089198 | Ostroff | Apr 2012 | A1 |
| 20120089214 | Kroll | Apr 2012 | A1 |
| 20120093245 | Makdissi et al. | Apr 2012 | A1 |
| 20120095521 | Hintz | Apr 2012 | A1 |
| 20120095539 | Khairkhahan et al. | Apr 2012 | A1 |
| 20120101540 | O'Brien et al. | Apr 2012 | A1 |
| 20120101553 | Reddy | Apr 2012 | A1 |
| 20120109148 | Bonner et al. | May 2012 | A1 |
| 20120109149 | Bonner et al. | May 2012 | A1 |
| 20120109235 | Sheldon et al. | May 2012 | A1 |
| 20120109236 | Jacobson et al. | May 2012 | A1 |
| 20120109259 | Bond et al. | May 2012 | A1 |
| 20120116489 | Khairkhahan et al. | May 2012 | A1 |
| 20120150251 | Giftakis et al. | Jun 2012 | A1 |
| 20120158111 | Khairkhahan et al. | Jun 2012 | A1 |
| 20120165827 | Khairkhahan et al. | Jun 2012 | A1 |
| 20120172690 | Anderson et al. | Jul 2012 | A1 |
| 20120172891 | Lee | Jul 2012 | A1 |
| 20120172892 | Grubac et al. | Jul 2012 | A1 |
| 20120172942 | Berg | Jul 2012 | A1 |
| 20120197350 | Roberts et al. | Aug 2012 | A1 |
| 20120197373 | Khairkhahan et al. | Aug 2012 | A1 |
| 20120215285 | Tahmasian et al. | Aug 2012 | A1 |
| 20120232478 | Haslinger | Sep 2012 | A1 |
| 20120232563 | Williams et al. | Sep 2012 | A1 |
| 20120232565 | Kveen et al. | Sep 2012 | A1 |
| 20120245665 | Friedman et al. | Sep 2012 | A1 |
| 20120263218 | Dal Molin et al. | Oct 2012 | A1 |
| 20120277600 | Greenhut | Nov 2012 | A1 |
| 20120277606 | Ellingson et al. | Nov 2012 | A1 |
| 20120277725 | Kassab et al. | Nov 2012 | A1 |
| 20120283587 | Gosh et al. | Nov 2012 | A1 |
| 20120283795 | Stancer et al. | Nov 2012 | A1 |
| 20120283807 | Deterre et al. | Nov 2012 | A1 |
| 20120284003 | Gosh et al. | Nov 2012 | A1 |
| 20120290025 | Keimel | Nov 2012 | A1 |
| 20120296228 | Zhang et al. | Nov 2012 | A1 |
| 20120296381 | Matos | Nov 2012 | A1 |
| 20120303082 | Dong et al. | Nov 2012 | A1 |
| 20120316613 | Keefe et al. | Dec 2012 | A1 |
| 20130012151 | Hankins | Jan 2013 | A1 |
| 20130013017 | Mullen et al. | Jan 2013 | A1 |
| 20130023975 | Locsin | Jan 2013 | A1 |
| 20130035748 | Bonner et al. | Feb 2013 | A1 |
| 20130041422 | Jacobson | Feb 2013 | A1 |
| 20130053906 | Ghosh et al. | Feb 2013 | A1 |
| 20130053908 | Smith et al. | Feb 2013 | A1 |
| 20130053915 | Holmstrom et al. | Feb 2013 | A1 |
| 20130053921 | Bonner et al. | Feb 2013 | A1 |
| 20130060298 | Splett et al. | Mar 2013 | A1 |
| 20130066169 | Rys et al. | Mar 2013 | A1 |
| 20130072770 | Rao et al. | Mar 2013 | A1 |
| 20130079798 | Tran et al. | Mar 2013 | A1 |
| 20130079861 | Reinert et al. | Mar 2013 | A1 |
| 20130085350 | Schugt et al. | Apr 2013 | A1 |
| 20130085403 | Gunderson et al. | Apr 2013 | A1 |
| 20130085550 | Polefko et al. | Apr 2013 | A1 |
| 20130096649 | Martin et al. | Apr 2013 | A1 |
| 20130103047 | Steingisser et al. | Apr 2013 | A1 |
| 20130103109 | Jacobson | Apr 2013 | A1 |
| 20130110008 | Bourg et al. | May 2013 | A1 |
| 20130110127 | Bornzin et al. | May 2013 | A1 |
| 20130110192 | Tran et al. | May 2013 | A1 |
| 20130110219 | Bornzin et al. | May 2013 | A1 |
| 20130116529 | Min et al. | May 2013 | A1 |
| 20130116738 | Samade et al. | May 2013 | A1 |
| 20130116739 | Brada et al. | May 2013 | A1 |
| 20130116740 | Bornzin et al. | May 2013 | A1 |
| 20130116741 | Bornzin et al. | May 2013 | A1 |
| 20130123872 | Bornzin et al. | May 2013 | A1 |
| 20130123875 | Varady et al. | May 2013 | A1 |
| 20130131591 | Berthiaume et al. | May 2013 | A1 |
| 20130131693 | Berthiaume et al. | May 2013 | A1 |
| 20130131750 | Stadler et al. | May 2013 | A1 |
| 20130131751 | Stadler et al. | May 2013 | A1 |
| 20130150695 | Biela et al. | Jun 2013 | A1 |
| 20130150911 | Perschbacher et al. | Jun 2013 | A1 |
| 20130150912 | Perschbacher et al. | Jun 2013 | A1 |
| 20130184776 | Shuros et al. | Jul 2013 | A1 |
| 20130196703 | Masoud et al. | Aug 2013 | A1 |
| 20130197599 | Sambelashvili et al. | Aug 2013 | A1 |
| 20130197609 | Moore et al. | Aug 2013 | A1 |
| 20130231710 | Jacobson | Sep 2013 | A1 |
| 20130238072 | Deterre et al. | Sep 2013 | A1 |
| 20130238073 | Makdissi et al. | Sep 2013 | A1 |
| 20130253342 | Griswold et al. | Sep 2013 | A1 |
| 20130253343 | Walfhauser et al. | Sep 2013 | A1 |
| 20130253344 | Griswold et al. | Sep 2013 | A1 |
| 20130253345 | Griswold et al. | Sep 2013 | A1 |
| 20130253346 | Griswold et al. | Sep 2013 | A1 |
| 20130253347 | Griswold et al. | Sep 2013 | A1 |
| 20130261497 | Pertijs et al. | Oct 2013 | A1 |
| 20130265144 | Banna et al. | Oct 2013 | A1 |
| 20130268017 | Zhang et al. | Oct 2013 | A1 |
| 20130268042 | Hastings et al. | Oct 2013 | A1 |
| 20130274828 | Willis | Oct 2013 | A1 |
| 20130274847 | Ostroff | Oct 2013 | A1 |
| 20130282070 | Cowan et al. | Oct 2013 | A1 |
| 20130282073 | Cowan et al. | Oct 2013 | A1 |
| 20130138006 | Bornzin et al. | Nov 2013 | A1 |
| 20130296727 | Sullivan et al. | Nov 2013 | A1 |
| 20130303872 | Taff et al. | Nov 2013 | A1 |
| 20130324825 | Ostroff et al. | Dec 2013 | A1 |
| 20130325081 | Karst et al. | Dec 2013 | A1 |
| 20130345770 | Dianaty et al. | Dec 2013 | A1 |
| 20140012344 | Hastings et al. | Jan 2014 | A1 |
| 20140018876 | Ostroff | Jan 2014 | A1 |
| 20140018877 | Demmer et al. | Jan 2014 | A1 |
| 20140031836 | Ollivier | Jan 2014 | A1 |
| 20140039591 | Drasler et al. | Feb 2014 | A1 |
| 20140043146 | Makdissi et al. | Feb 2014 | A1 |
| 20140046395 | Regnier et al. | Feb 2014 | A1 |
| 20140046420 | Moore et al. | Feb 2014 | A1 |
| 20140058240 | Mothilal et al. | Feb 2014 | A1 |
| 20140058494 | Ostroff et al. | Feb 2014 | A1 |
| 20140339570 | Carroll et al. | Feb 2014 | A1 |
| 20140074114 | Khairkhahan et al. | Mar 2014 | A1 |
| 20140074186 | Faltys et al. | Mar 2014 | A1 |
| 20140094891 | Pare et al. | Apr 2014 | A1 |
| 20140100627 | Min | Apr 2014 | A1 |
| 20140107723 | Hou | Apr 2014 | A1 |
| 20140114173 | Bar-Tal et al. | Apr 2014 | A1 |
| 20140114372 | Ghosh et al. | Apr 2014 | A1 |
| 20140121719 | Bonner et al. | May 2014 | A1 |
| 20140121720 | Bonner et al. | May 2014 | A1 |
| 20140121722 | Sheldon et al. | May 2014 | A1 |
| 20140128935 | Kumar et al. | May 2014 | A1 |
| 20140135865 | Hastings et al. | May 2014 | A1 |
| 20140142648 | Smith et al. | May 2014 | A1 |
| 20140148675 | Nordstrom et al. | May 2014 | A1 |
| 20140148815 | Wenzel et al. | May 2014 | A1 |
| 20140155950 | Hastings et al. | Jun 2014 | A1 |
| 20140169162 | Romano et al. | Jun 2014 | A1 |
| 20140172060 | Bornzin et al. | Jun 2014 | A1 |
| 20140180306 | Grubac et al. | Jun 2014 | A1 |
| 20140180366 | Edlund | Jun 2014 | A1 |
| 20140207149 | Hastings et al. | Jul 2014 | A1 |
| 20140207210 | Willis et al. | Jul 2014 | A1 |
| 20140214104 | Greenhut et al. | Jul 2014 | A1 |
| 20140222098 | Baru et al. | Aug 2014 | A1 |
| 20140222109 | Moulder | Aug 2014 | A1 |
| 20140228913 | Molin et al. | Aug 2014 | A1 |
| 20140236172 | Hastings et al. | Aug 2014 | A1 |
| 20140243848 | Auricchio et al. | Aug 2014 | A1 |
| 20140255298 | Cole et al. | Sep 2014 | A1 |
| 20140257324 | Fain | Sep 2014 | A1 |
| 20140257422 | Herken | Sep 2014 | A1 |
| 20140257444 | Cole et al. | Sep 2014 | A1 |
| 20140276929 | Foster et al. | Sep 2014 | A1 |
| 20140303704 | Suwito et al. | Oct 2014 | A1 |
| 20140309706 | Jacobson | Oct 2014 | A1 |
| 20140323882 | Ghosh et al. | Oct 2014 | A1 |
| 20140323892 | Ghosh et al. | Oct 2014 | A1 |
| 20140330208 | Christie et al. | Nov 2014 | A1 |
| 20140330287 | Thompson-Nauman et al. | Nov 2014 | A1 |
| 20140330326 | Thompson-Nauman et al. | Nov 2014 | A1 |
| 20140358135 | Sambelashvili et al. | Dec 2014 | A1 |
| 20140371832 | Ghosh | Dec 2014 | A1 |
| 20140371833 | Ghosh et al. | Dec 2014 | A1 |
| 20140379041 | Foster | Dec 2014 | A1 |
| 20150025612 | Haasl et al. | Jan 2015 | A1 |
| 20150039041 | Smith et al. | Feb 2015 | A1 |
| 20150051609 | Schmidt et al. | Feb 2015 | A1 |
| 20150051610 | Schmidt et al. | Feb 2015 | A1 |
| 20150051611 | Schmidt et al. | Feb 2015 | A1 |
| 20150051612 | Schmidt et al. | Feb 2015 | A1 |
| 20150051613 | Schmidt et al. | Feb 2015 | A1 |
| 20150051614 | Schmidt et al. | Feb 2015 | A1 |
| 20150051615 | Schmidt et al. | Feb 2015 | A1 |
| 20150051616 | Haasl et al. | Feb 2015 | A1 |
| 20150051682 | Schmidt et al. | Feb 2015 | A1 |
| 20150057520 | Foster et al. | Feb 2015 | A1 |
| 20150057558 | Stahmann et al. | Feb 2015 | A1 |
| 20150057721 | Stahmann et al. | Feb 2015 | A1 |
| 20150088155 | Foster et al. | Mar 2015 | A1 |
| 20150105836 | Bonner et al. | Apr 2015 | A1 |
| 20150142070 | Sambelashvili | May 2015 | A1 |
| 20150148697 | Burnes et al. | May 2015 | A1 |
| 20150149096 | Soykan | May 2015 | A1 |
| 20150157861 | Aghassian | Jun 2015 | A1 |
| 20150173655 | Demmer et al. | Jun 2015 | A1 |
| 20150190638 | Smith et al. | Jul 2015 | A1 |
| 20150196756 | Stahmann et al. | Jul 2015 | A1 |
| 20150196757 | Stahmann et al. | Jul 2015 | A1 |
| 20150196758 | Stahmann et al. | Jul 2015 | A1 |
| 20150196769 | Stahmann et al. | Jul 2015 | A1 |
| 20150217119 | Nikolski et al. | Aug 2015 | A1 |
| 20150221898 | Chi et al. | Aug 2015 | A1 |
| 20150224315 | Stahmann | Aug 2015 | A1 |
| 20150224320 | Stahmann | Aug 2015 | A1 |
| 20150258345 | Smith et al. | Sep 2015 | A1 |
| 20150290468 | Zhang | Oct 2015 | A1 |
| 20150297905 | Greenhut et al. | Oct 2015 | A1 |
| 20150297907 | Zhang | Oct 2015 | A1 |
| 20150305637 | Greenhut et al. | Oct 2015 | A1 |
| 20150305638 | Zhang | Oct 2015 | A1 |
| 20150305639 | Greenhut et al. | Oct 2015 | A1 |
| 20150305640 | Reinke et al. | Oct 2015 | A1 |
| 20150305641 | Stadler et al. | Oct 2015 | A1 |
| 20150305642 | Reinke et al. | Oct 2015 | A1 |
| 20150305695 | Lahm et al. | Oct 2015 | A1 |
| 20150306374 | Seifert et al. | Oct 2015 | A1 |
| 20150306375 | Marshall et al. | Oct 2015 | A1 |
| 20150306406 | Crutchfield et al. | Oct 2015 | A1 |
| 20150306407 | Crutchfield et al. | Oct 2015 | A1 |
| 20150306408 | Greenhut et al. | Oct 2015 | A1 |
| 20150321016 | O'Brien et al. | Nov 2015 | A1 |
| 20150328459 | Chin et al. | Nov 2015 | A1 |
| 20150335894 | Bornzin et al. | Nov 2015 | A1 |
| 20160015287 | Anderson et al. | Jan 2016 | A1 |
| 20160015322 | Anderson et al. | Jan 2016 | A1 |
| 20160023000 | Cho et al. | Jan 2016 | A1 |
| 20160030757 | Jacobson | Feb 2016 | A1 |
| 20160033177 | Barot et al. | Feb 2016 | A1 |
| 20160045738 | Ghosh et al. | Feb 2016 | A1 |
| 20160051821 | Sambelashvili et al. | Feb 2016 | A1 |
| 20160059002 | Grubac et al. | Mar 2016 | A1 |
| 20160067486 | Brown et al. | Mar 2016 | A1 |
| 20160067487 | Demmer et al. | Mar 2016 | A1 |
| 20160067490 | Carney et al. | Mar 2016 | A1 |
| 20160114161 | Amblard et al. | Apr 2016 | A1 |
| 20160121127 | Klimovitch et al. | May 2016 | A1 |
| 20160121128 | Fishler et al. | May 2016 | A1 |
| 20160121129 | Persson et al. | May 2016 | A1 |
| 20160129239 | Anderson | May 2016 | A1 |
| 20160213919 | Suwito et al. | Jul 2016 | A1 |
| 20160213937 | Reinke et al. | Jul 2016 | A1 |
| 20160213939 | Carney et al. | Jul 2016 | A1 |
| 20160228026 | Jackson | Aug 2016 | A1 |
| 20160310733 | Sheldon et al. | Oct 2016 | A1 |
| 20160317825 | Jacobson | Nov 2016 | A1 |
| 20160367823 | Cowan et al. | Dec 2016 | A1 |
| 20170014629 | Ghosh et al. | Jan 2017 | A1 |
| 20170035315 | Jackson | Feb 2017 | A1 |
| 20170043173 | Sharma et al. | Feb 2017 | A1 |
| 20170043174 | Greenhut et al. | Feb 2017 | A1 |
| 20170056670 | Sheldon et al. | Mar 2017 | A1 |
| 20170182327 | Liu | Jun 2017 | A1 |
| 20170189681 | Anderson | Jul 2017 | A1 |
| 20170209689 | Chen | Jul 2017 | A1 |
| 20170216575 | Asleson et al. | Aug 2017 | A1 |
| 20170304624 | Friedman et al. | Oct 2017 | A1 |
| 20170326369 | Koop et al. | Nov 2017 | A1 |
| 20170340885 | Sambelashvili | Nov 2017 | A1 |
| 20180008829 | An et al. | Jan 2018 | A1 |
| 20180021567 | An et al. | Jan 2018 | A1 |
| 20180021581 | An et al. | Jan 2018 | A1 |
| 20180021582 | An et al. | Jan 2018 | A1 |
| 20180050208 | Shuros et al. | Feb 2018 | A1 |
| 20180078773 | Thakur et al. | Mar 2018 | A1 |
| 20180078779 | An et al. | Mar 2018 | A1 |
| 20180117324 | Schilling et al. | May 2018 | A1 |
| 20180140848 | Stahmann | May 2018 | A1 |
| 20180178007 | Shuros et al. | Jun 2018 | A1 |
| 20180212451 | Schmidt et al. | Jul 2018 | A1 |
| 20180264262 | Haasl et al. | Sep 2018 | A1 |
| 20180264272 | Haasl et al. | Sep 2018 | A1 |
| 20180264273 | Haasl et al. | Sep 2018 | A1 |
| 20180264274 | Haasl et al. | Sep 2018 | A1 |
| 20180280686 | Shuros et al. | Oct 2018 | A1 |
| 20180326215 | Ghosh | Nov 2018 | A1 |
| 20190030346 | Li | Jan 2019 | A1 |
| 20190038906 | Koop et al. | Feb 2019 | A1 |
| 20190083779 | Yang et al. | Mar 2019 | A1 |
| 20190083800 | Yang et al. | Mar 2019 | A1 |
| 20190083801 | Yang et al. | Mar 2019 | A1 |
| 20190192860 | Ghosh et al. | Jun 2019 | A1 |
| 20190269926 | Ghosh | Sep 2019 | A1 |
| Number | Date | Country |
|---|---|---|
| 2008279789 | Oct 2011 | AU |
| 2008329620 | May 2014 | AU |
| 2014203793 | Jul 2014 | AU |
| 202933393 | May 2013 | CN |
| 0362611 | Apr 1990 | EP |
| 0459 239 | Dec 1991 | EP |
| 0 728 497 | Aug 1996 | EP |
| 1 541 191 | Jun 2005 | EP |
| 1 702 648 | Sep 2006 | EP |
| 1 904 166 | Jun 2011 | EP |
| 2 452 721 | May 2012 | EP |
| 2 471 452 | Jul 2012 | EP |
| 2 662 113 | Nov 2013 | EP |
| 1 703 944 | Jul 2015 | EP |
| 2005245215 | Sep 2005 | JP |
| WO 9500202 | Jan 1995 | WO |
| WO 9636134 | Nov 1996 | WO |
| WO 9724981 | Jul 1997 | WO |
| WO 0222206 | Mar 2002 | WO |
| WO 03092800 | Nov 2003 | WO |
| WO 2005000206 | Jan 2005 | WO |
| WO 2005042089 | May 2005 | WO |
| WO 2006086435 | Aug 2006 | WO |
| WO 2006113659 | Oct 2006 | WO |
| WO 2007073435 | Jun 2007 | WO |
| WO 2007075974 | Jul 2007 | WO |
| WO 2009006531 | Jan 2009 | WO |
| WO 2013080038 | Jun 2013 | WO |
| WO 2013098644 | Jul 2013 | WO |
| WO 2015081221 | Jun 2015 | WO |
| WO 2016011042 | Jan 2016 | WO |
| WO 2016077099 | May 2016 | WO |
| WO 2016110856 | Jul 2016 | WO |
| WO 2016171891 | Oct 2016 | WO |
| WO 2017075193 | May 2017 | WO |
| WO 2018009569 | Jan 2018 | WO |
| WO 2018017226 | Jan 2018 | WO |
| WO 2018017361 | Jan 2018 | WO |
| WO 2018035343 | Feb 2018 | WO |
| WO 2018081519 | May 2018 | WO |
| Entry |
|---|
| US 8,886,318 B2, 11/2014, Jacobson et al. (withdrawn) |
| Schoonderwoerd et al., “Atrial ultrastructural changes during experimental atrial tachycardia depend on high ventricular rate,” J Cardiovasc Electrophysiol., Oct. 2004; 15(10):1167-74. |
| Sedmera, “Function and form in the developing cardiovascular system,” Cardiovasc Res., Jul. 2011; 91(2):252-9. |
| Severi et al., “Alterations of atrial electrophysiology induced by electrolyte variations: combined computational and P-wave analysis,” Europace, Jun. 2010; 12(6):842-9. |
| Seyedi et al., “A Survey on Intrabody Communications for Body Area Network Application,” IEEE Transactions on Biomedical Engineering, vol. 60(8): 2067-2079, 2013. |
| Shah et al., “Stable atrial sensing on long-term follow up of VDD pacemakers,” Indian Pacing and Electrophysiology Journal, Oct. 2006; 6(4):189-93. |
| Shenthar et al., “Permanent pacemaker implantation in a patient with situs solitus, dextrocardia, and corrected transposition of the great arteries using a novel angiographic technique,” Journal of Arrhythmia, Apr. 2014; 30(2):134-138. |
| Shenthar et al., “Transvenous permanent pacemaker implantation in dextrocardia: technique, challenges, outcome, and a brief review of literature,” Europace, Sep. 2014; 16(9):1327-33. |
| Shirayama, “Role of atrial fibrillation threshold evaluation on guiding treatment,” Indian Pacing and Electrophysiology Journal, Oct. 2003; 3(4):224-230. |
| Sperzel et al., “Intraoperative Characterization of Interventricular Mechanical Dyssynchrony Using Electroanatomic Mapping System—A Feasibility Study,” Journal of Interventional Cardiac Electrophysiology, Nov. 2012, 35(2): 189-96. |
| Spickler et al., “Totally Self-Contained Intracardiac Pacemaker,” Journal of Electrocardiology, vol. 3(3&4): 324-331, 1970. |
| Sreeram et al., “Indications for Electrophysiology Study in children,” Indian Pacing and Electrophysiology Journal, Apr.-Jun. 2008; 8(Suppl. 1):S36-S54. |
| Stockburger et al., “Optimization of cardiac resynchronization guided by Doppler echocardiography: haemodynamic improvement and intraindividual variability with different pacing configurations and atrioventricular delays,” Europace, Oct. 2006; 8(10):881-6. |
| Stroobandt et al., “Prediction of Wenckebach Behavior and Block Response in DDD Pacemakers,” Pacing Clin Electrophysiol., Jun. 2006; 9(6):1040-6. |
| Suenari et al., “Idiopathic left ventricular tachycardia with dual electrocardiogram morphologies in a single patient,” Europace, Apr. 2010; 12(4):592-4. |
| Sweeney et al., “Analysis of Ventricular Activation Using Surface Electrocardiogramo Predict Left Ventricular Reverse Volumetric Remodeling During Cardiac Resynchronization Therapy,” Circulation, Feb. 9, 2010, 121(5): 626-34. |
| Tan et al., “Electrocardiogramvidence of ventricular repolarization remodelling during atrial fibrillation,” Europace, Jan. 2008; 10(1):99-104. |
| Taramasco et al., “Internal low-energy cardioversion: a therapeutic option for restoring sinus rhythm in chronic atrial fibrillation after failure of external cardioversion,” Europace, Jul. 1999; 1(3): 179-82. |
| Testa et al., “Rate-control or rhythm-control: where do we stand?” Indian Pacing and Electrophysiology Journal, Oct. 2005; 5(4):296-304. |
| Thejus et al., “N-terminal Pro-Brain Natriuretic Peptide and Atrial Fibrillation,” Indian Pacing and Electrophysiology Journal, Jan. 2009; 9(1):1-4. |
| Thornton et al., “Magnetic Assisted Navigation in Electrophysiology and Cardiac Resynchronisation: A Review,” Indian Pacing and Electrophysiology Journal, Oct. 2006; 6(4):202-13. |
| Tilz et al., “In vivo left-ventricular contact force analysis: comparison of antegrade transseptal with retrograde transaortic mapping strategies and correlation of impedance and electrical amplitude with contact force,” Europace, Sep. 2014; 16(9):1387-95. |
| Tomaske et al., “Do daily threshold trend fluctuations of epicardial leads correlate with pacing and sensing characteristics in paediatric patients?” Europace, Aug. 2007; 9(8):662-668. |
| Tomioka et al., “The effect of ventricular sequential contraction on helical heart during pacing: high septal pacing versus biventricular pacing,” European Journal of Cardio-thoracic Surgery, Apr. 1, 2006; 29S1:S198-206. |
| Tournoux et al., “A ‘Regularly Irregular’ tachycardia: What is the diagnosis?” Europace, Dec. 2008; 10(12):1445-6. |
| Traykov et al., “Electrogram analysis at the His bundle region and the proximal coronary sinus as a tool to predict left atrial origin of focal atrial tachycardias,” Europace, Jul. 2011; 13(7):1022-7. |
| Trudel et al., “Simulation of QRST integral maps with a membrane-based computer heart model employing parallel processing,” IEEE Trans Biomed Eng., Aug. 2004; 51(8):1319-29. |
| Tse et al., “Cardiac dynamics: Alternans and arrhythmogenesis,” Journal of Arrhythmia, Oct. 2016; 32(5):411-417. |
| Tse, “Mechanisms of cardiac arrhythmias,” Journal of Arrhythmia, Apr. 2016; 32(2):75-81. |
| Ueda et al., “Outcomes of single- or dual-chamber implantable cardioverter defibrillator systems in Japanese patients,” Journal of Arrhythmia, Apr. 2016; 32(2):89-94. |
| Van Dam et al., “Volume conductor effects involved in the genesis of the P wave,” Europace, Sep. 2005; 7 Suppl 2:30-8. |
| Van den Berg et al., “Depletion of atrial natriuretic peptide during longstanding atrial fibrillation,” Europace, Sep. 2004; 6(5):433-7. |
| Van Deursen, et al., “Vectorcardiography as a Tool for Easy Optimization of Cardiac Resynchronization Therapy in Canine LBBB Hearts,” Circulation Arrhythmia and Electrophysiology, Jun. 1, 2012, 5(3): 544-52. |
| Van Opstal et al., “Paradoxical increase of stimulus to atrium interval despite His-bundle capture during para-Hisian pacing,” Europace, Dec. 2009; 11(12):1702-4. |
| Veenhuyzen et al., “Diagnostic pacing maneuvers for supraventricular tachycardia: part 1,” Pacing Clin Electrophysiol., Jun. 2011; 34(6):767-82. |
| Veenhuyzen et al., “Diagnostic pacing maneuvers for supraventricular tachycardias: part 2,” Pacing Clin Electrophysiol., Jun. 2012; 35(6):757-69. |
| Veenhuyzen et al., “Principles of Entrainment: Diagnostic Utility for Supraventricular Tachycardia,” Indian Pacing and Electrophysiology Journal, 2008; 8(1):51-65. |
| Verbrugge et al., “Revisiting diastolic filling time as mechanistic insight for response to cardiac resynchronization therapy,” Europace, Dec. 2013; 15(12):1747-56. |
| Verrier et al., “Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation,” Europace, Mar. 2013; 15(3):317-324. |
| Verrijcken et al., “Pacemaker-mediated tachycardia with varying cycle length: what is the mechanism?” Europace, Oct. 2009; 11(10):1400-2. |
| Villani et al., “Reproducibility of internal atrial defibrillation threshold in paroxysmal and persistent atrial fibrillation,” Europace, Jul. 2004; 6(4):267-72. |
| Violi et al., “Antioxidants for prevention of atrial fibrillation: a potentially useful future therapeutic approach? A review of the literature and meta-analysis,” Europace, Aug. 2014; 16(8):1107-1116. |
| Weber et al., “Adenosine sensitive focal atrial tachycardia originating from the non-coronary aortic cusp,” Europace, Jun. 2009; 11(6):823-6. |
| Weber et al., “Open-irrigated laser catheter ablation: relationship between the level of energy, myocardial thickness, and collateral damages in a dog model,” Europace, Jan. 2014; 16(1):142-8. |
| Wegmoller, “Intra-Body Communication for Biomedical Sensor Networks,” Diss. ETH, No. 17323, 1-173, 2007. |
| Wei et al., “Comparative simulation of excitation and body surface electrocardiogram with isotropic and anisotropic computer heart models,” IEEE Trans Biomed Eng., Apr. 1995; 42(4):343-57. |
| Weijs et al., “Clinical and echocardiographic correlates of intra-atrial conduction delay,” Europace, Dec. 2011; 13(12):1681-7. |
| Weiss et al., “The influence of fibre orientation, extracted from different segments of the human left ventricle, on the activation and repolarization sequence: a simulation study,” Europace, Nov. 2007; 9(Suppl. 6):vi96-vi104. |
| Wetzel et al., “A stepwise mapping approach for localization and ablation of ectopic right, left, and septal atrial foci using electroanatomic mapping,” European Heart Journal, Sep. 2002; 23(17):1387-1393. |
| Wlodarska et al., “Thromboembolic complications in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy,” Europace, Aug. 2006; 8(8):596-600. |
| Wong et al., “A review of mitral isthmus ablation,” Indian Pacing and Electrophysiology Journal, 2012; 12(4):152-170. |
| Wu et al., “Acute and long-term outcome after catheter ablation of supraventricular tachycardia in patients after the Mustard or Senning operation for D-transposition of the great arteries,” Europace, Jun. 2013; 15(6):886-91. |
| Xia et al., “Asymmetric dimethylarginine concentration and early recurrence of atrial fibrillation after electrical cardioversion,” Pacing Clin Electrophysiol., Aug. 2008; 31(8):1036-40. |
| Yamazaki et al., “Acute Regional Left Atrial Ischemia Causes Acceleration of Atrial Drivers during Atrial Fibrillation,” Heart Rhythm, Jun. 2013; 10(6):901-9. |
| Yang et al., “Focal atrial tachycardia originating from the distal portion of the left atrial appendage: Characteristics and long-term outcomes of radiofrequency ablation,” Europace, Feb. 2012; 14(2):254-60. |
| Yiginer et al., “Advanced Age, Female Gender and Delay in Pacemaker Implantation May Cause TdP in Patients With Complete Atrioventricular Block,” Indian Pacing and Electrophysiology Journal, Oct. 2010; 10(10):454-63. |
| Yoon et al., “Measurement of thoracic current flow in pigs for the study of defibrillation and cardioversion,” IEEE Transactions on Biomedical Engineering, Oct. 2003; 50(10):1167-1773. |
| Yuan et al., “Recording monophasic action potentials using a platinum-electrode ablation catheter,” Europace, Oct. 2000; 2(4):312-9. |
| Yusuf et al., “5-Hydroxytryptamine and Atrial Fibrillation: How Significant is This Piece in the Puzzle?” J Cardiovasc Electrophysiol., Feb. 2003; 14(2):209-14. |
| Zaugg et al., “Current concepts on ventricular fibrillation: a vicious circle of cardiomyocyte calcium overload in the initiation, maintenance, and termination of ventricular fibrillation,” Indian Pacing and Electrophysiology Journal, Apr. 2004; 4(2):85-92. |
| Zhang et al., “Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts,” Cardiovascular Research, Mar. 2011; 89(4):794-804. |
| Zoghi et al., “Electrical stunning and hibernation: suggestion of new terms for short- and long-term cardiac memory,” Europace, Sep. 2004; 6(5):418-24. |
| Zografos et al., “Inhibition of the renin-angiotensin system for prevention of atrial fibrillation,” Pacing Clin Electrophysiol., Oct. 2010; 33(10):1270-85. |
| (PCT/US2014/066792) PCT Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority. |
| (PCT/US2014/013601) PCT Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority. |
| (PCT/US2014/036782) PCT Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, dated Aug. 22, 2014, 11 pages. |
| International Search Report and Written Opinion for Application No. PCT/US2017/047378, 8 pages, dated Dec. 6, 2017. |
| (PCT/US2018/050988) PCT Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, dated Nov. 14, 2018, 11 pages. |
| (PCT/US2018/050993) PCT Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, dated Nov. 16, 2018, 7 pages. |
| (PCT/US2019/023642) PCT Notification of Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, dated Jun. 28, 2019, 14 pages. |
| International Preliminary Report on Patentability from PCT Application No. PCT/US2019/023645 dated Oct. 8, 2020, 7 pages. |
| International Preliminary Report on Patentability from PCT Application No. PCT/US2019/023636 dated Oct. 8, 2020, 9 pages. |
| International Preliminary Report on Patentability from PCT Application No. PCT/US2019/023642 dated Oct. 8, 2020, 9 pages. |
| http://www.isrctn.com/ISRCTN47824547, public posting published Aug. 2019. |
| Abed et al., “Obesity results in progressive atrial structural and electrical remodeling: Implications for atrial fibrillation,” Heart Rhythm Society, Jan. 2013; 10(1):90-100. |
| Adragão et al., “Ablation of pulmonary vein foci for the treatment of atrial fibrillation; percutaneous electroanatomical guided approach,” Europace, Oct. 2002; 4(4):391-9. |
| Aliot et al., “Arrhythmia detection by dual-chamber implantable cardioverter defibrillators: A review of current algorithms,” Europace, Jul. 2004; 6(4):273-86. |
| Amirahmadi et al., “Ventricular Tachycardia Caused by Mesothelial Cyst,” Indian Pacing and Electrophysiology Journal, 2013; 13(1):43-44. |
| Ammirabile et al., “Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium,” Cardiovasc Res., Feb. 2012; 93(2):291-301. |
| Anfinsen, “Non-pharmacological Treatment of Atrial Fibrillation,” Indian Pacing and Electrophysiology Journal, Jan. 2002; 2(1):4-14. |
| Anné et al., “Ablation of post-surgical intra-atrial reentrant Tachycardia,” European Heart Journal, 2002; 23:169-1616. |
| Arenal et al., “Dominant frequency differences in atrial fibrillation patients with and without left ventricular systolic dysfunction,” Europace, Apr. 2009; 11(4):450-457. |
| Arriagada et al., “Predictors of arrhythmia recurrence in patients with lone atrial fibrillation,” Europace, Jan. 2008; 10(1):9-14. |
| Asirvatham et al., “Cardiac Anatomic Considerations in Pediatric Electrophysiology,” Indian Pacing and Electrophysiology Journal, Apr. 2008; 8(Suppl 1):S75-S91. |
| Asirvatham et al., “Intramyocardial Pacing and Sensing for the Enhancement of Cardiac Stimulation and Sensing Specificity,” Pacing Clin. Electrophysiol., Jun. 2007; 30(6):748-754. |
| Asirvatham et al., “Letter to the Editor,” J Cardiovasc Electrophysiol., Mar. 2010; 21(3): E77. |
| Balmer et al., “Long-term follow up of children with congenital complete atrioventricular block and the impact of pacemaker therapy,” Europace, Oct. 2002; 4(4):345-349. |
| Barold et al., “Conventional and biventricular pacing in patients with first-degree atrioventricular block,” Europace, Oct. 2012; 14(10):1414-9. |
| Barold et al., “The effect of hyperkalaemia on cardiac rhythm devices,” Europace, Apr. 2014; 16(4):467-76. |
| Bayrak et al., “Added value of transoesophageal echocardiography during transseptal puncture performed by inexperienced operators,” Europace, May 2012; 14(5):661-5. |
| Bergau et al., “Measurement of Left Atrial Pressure is a Good Predictor of Freedom From Atrial Fibrillation,” Indian Pacing and Electrophysiology Journal, Jul. 2014; 14(4):181-93. |
| Bernstein et al., “The revised NASPE/BPEG generic code for antibradycardia, adaptive-rate, and multisite pacing. North American Society of Pacing and Electrophysiology/British Pacing and Electrophysiology Group,” Pacing Clin Electrophysiol., Feb. 2002; 25(2):260-4. |
| Bito et al., “Early exercise training after myocardial infarction prevents contractile but not electrical remodeling or hypertrophy,” Cardiovascular Research, Apr. 2010; 86(1):72-81. |
| Bollmann et al., “Analysis of surface electrocardiograms in atrial fibrillation: techniques, research, and clinical applications,” Europace, Nov. 2006; 8(11):911-926. |
| Bortone et al., “Evidence for an incomplete mitral isthmus block after failed ablation of a left postero-inferior concealed accessory pathway,” Europace, Jun. 2006; 8(6):434-7. |
| Boulos et al., “Electroanatomical mapping and radiofrequency ablation of an accessory pathway associated with a large aneurysm of the coronary sinus,” Europace, Nov. 2004; 6(6):608-12. |
| Brembilla-Perrot et al., “Incidence and prognostic significance of spontaneous and inducible antidromic tachycardia,” Europace, Jun. 2013; 15(6):871-876. |
| Buber et al., “Morphological features of the P-waves at surface electrocardiogram as surrogate to mechanical function of the left atrium following a successful modified maze procedure,” Europace, Apr. 2014; 16(4):578-86. |
| Burashnikov et al., “Late-phase 3 EAD. A unique mechanism contributing to initiation of atrial fibrillation,” Pacing Clin Electrophysiol., Mar. 2006; 29(3):290-5. |
| Burashnikov et al., “Atrial-selective inhibition of sodium-channel current by Wenxin Keli is effective in suppressing atrial fibrillation,” Heart Rhythm, Jan. 2012; 9(1):125-31. |
| Calvo et al., “Efficacy of circumferential pulmonary vein ablation of atrial fibrillation in endurance athletes,” Europace, Jan. 2010; 12(1):30-6. |
| Can et al., ““Atrial torsades de pointes” Induced by Low-Energy Shock From Implantable-Cardioverter Defibrillator,” Indian Pacing and Electrophysiology Journal, Sep. 2013; 13(5):194-199. |
| Carroz et al., “Pseudo-pacemaker syndrome in a young woman with first-degree atrio-ventricular block,” Europace, Apr. 2010; 12(4):594-596. |
| Catanchin et al., “Wolff-Parkinson-White syndrome with an unroofed coronary sinus without persistent left superior vena cava treated with catheter cryoablation,” Indian Pacing and Electrophysiology Journal, Aug. 2008; 8(3):227-233. |
| Cazeau et al., “Cardiac resynchronization therapy,” Europace, Sep. 2004; 5 Suppl 1:S42-8. |
| Chandra et al., “Evaluation of KCB-328, a new IKr blocking antiarrhythmic agent in pacing induced canine atrial fibrillation,” Europace, Sep. 2004; 6(5):384-91. |
| Chang et al., “Electrophysiological characteristics and catheter ablation in patients with paroxysmal supraventricular tachycardia and paroxysmal atrial fibrillation,” J Cardiovasc Electrophysiol., Apr. 2008; 19(4):367-73. |
| Charron et al., “A familial form of conduction defect related to a mutation in the PRKAG2 gene,” Europace, Aug. 2007; 9(8):597-600. |
| Chou et al., “Effects of SEA0400 on Arrhythmogenicity in a Langendorff-Perfused 1-Month Myocardial Infarction Rabbit Model,” Pacing Clin Electrophysiol., May 2013; 36(5):596-606. |
| Ciploetta et al., “Posterior Coronary Vein as the Substrate for an Epicardial Accessory Pathway,” Indian Pacing and Electrophysiology Journal, Aug. 2013; 13(4):142-7. |
| Climent et al., “Effects of endocardial microwave energy ablation,” Indian Pacing and Electrophysiology Journal, Jul. 2005; 5(3):233-43. |
| Comtois et al., “Of circles and spirals: bridging the gap between the leading circle and spiral wave concepts of cardiac reentry,” Europace, Sep. 2005; 7 Suppl 2:10-20. |
| Crick et al., “Anatomy of the pig heart: comparisons with normal human cardiac structure,” J. Anat., 1998, 193:105-119. |
| Daoulah et al., “Unintended Harm and Benefit of the Implantable Defibrillator in an Unfortunate 19-Year-Old Male: Featuring a Sequence of Rare Life-threatening Complications of Cardiac Procedures,” Indian Pacing and Electrophysiology Journal, Aug. 2013; 13(4):151-6. |
| De Mattia et al., “Paroxysmal atrial fibrillation triggered by a monomorphic ventricular couplet in a patient with acute coronary syndrome,” Indian Pacing and Electrophysiology Journal, Jan. 2012; 12(1):19-23. |
| DeSimone et al., “New approach to cardiac resynchronization therapy: CRT without left ventricular lead,” Apr. 25, 2014, 2 pages. |
| De Sisti et al., “Electrophysiological determinants of atrial fibrillation in sinus node dysfunction despite atrial pacing,” Europace, Oct. 2000; 2(4):304-11. |
| De Voogt et al., “Electrical characteristics of low atrial septum pacing compared with right atrial appendage pacing,” Europace, Jan. 2005; 7(1):60-6. |
| De Voogt et al., “A technique of lead insertion for low atrial septal pacing,” Pacing Clin Electrophysiol., Jul. 2005; 28(7):639-46. |
| Dizon et al. “Real-time stroke volume measurements for the optimization of cardiac resynchronization therapy parameters,” Europace, Sep. 2010; 12(9):1270-1274. |
| Duckett et al., “Relationship between endocardial activation sequences defined by high-density mapping to early septal contraction (septal flash) in patients with left bundle branch block undergoing cardiac resynchronization therapy,” Europace, Jan. 2012; 14(1):99-106. |
| Eksik et al., “Influence of atrioventricular nodal reentrant tachycardia ablation on right to left inter-atrial conduction,” Indian Pacing and Electrophysiology Journal, Oct. 2005; 5(4):279-88. |
| Fiala et al., “Left Atrial Voltage during Atrial Fibrillation in Paroxysmal and Persistent Atrial Fibrillation Patients,” PACE, May 2010; 33(5):541-548. |
| Fragakis et al., “Acute beta-adrenoceptor blockade improves efficacy of ibutilide in conversion of atrial fibrillation with a rapid ventricular rate,” Europace, Jan. 2009; 11(1):70-4. |
| Frogoudaki et al., “Pacing for adult patients with left atrial isomerism: efficacy and technical considerations,” Europace, Apr. 2003; 5(2):189-193. |
| Ganapathy et al., “Implantable Device to Monitor Cardiac Activity with Sternal Wires,” Pacing Clin. Electrophysiol., Dec. 2014; Epub Aug. 24, 2014; 37(12):1630-40. |
| Geddes, “Accuracy limitations of chronaxie values,” IEEE Trans Biomed Eng., Jan. 2004; 51(1):176-81. |
| Gertz et al., “The impact of mitral regurgitation on patients undergoing catheter ablation of atrial fibrillation,” Europace, Aug. 2011; 13(8):1127-32. |
| Girmatsion et al., “Changes in microRNA-1 expression and IK1 up-regulation in human atrial fibrillation,” Heart Rhythm, Dec. 2009; 6(12):1802-9. |
| Goette et al., “Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles,” European Heart Journal, Jun. 2009; 30(11):1411-20. |
| Goette et al., “Electrophysiological effects of angiotensin II. Part I: signal transduction and basic electrophysiological mechanisms,” Europace, Feb. 2008; 10(2):238-41. |
| Gómez et al., “Nitric oxide inhibits Kv4.3 and human cardiac transient outward potassium current (Ito1),” Cardiovasc Res., Dec. 2008; 80(3):375-84. |
| Gros et al., “Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate,” Cardiovascular Research, Jan. 2010; 85(1):45-55. |
| Guenther et al., “Substernal Lead Implantation: A Novel Option to Manage OFT Failure in S-ICD patients,” Clinical Research Cardiology, Feb. 2015; Epub Oct. 2, 2014; 104(2):189-91. |
| Guillem et al., “Noninvasive mapping of human atrial fibrillation,” J Cardiovasc Electrophysiol., May 2009; 20(5):507-513. |
| Hachisuka et al., “Development and Performance Analysis of an Intra-Body Communication Device,” The 12th International Conference on Solid State Sensors, Actuators and Microsystems, vol. 4A1.3, pp. 1722-1725, 2003. |
| Hakacova et al., “Septal atrial pacing for the prevention of atrial fibrillation.” Europace, 2007; 9:1124-1128. |
| Hasan et al., “Safety, efficacy, and performance of implanted recycled cardiac rhythm management (CRM) devices in underprivileged patients,” Pacing Clin Electrophysiol., Jun. 2011; 34(6):653-8. |
| Hawkins, “Epicardial Wireless Pacemaker for Improved Left Ventricular Reynchronization (Conceptual Design)”, Dec. 2010, A Thesis presented to the Faculty of California Polytechnic State University, San Luis Obispo, 57 pp. |
| He et al., “Three-dimensional cardiac electrical imaging from intracavity recordings,” IEEE Trans Biomed Eng., Aug. 2007; 54(8):1454-60. |
| Heist et al., “Direct visualization of epicardial structures and ablation utilizing a visually guided laser balloon catheter: preliminary findings,” J Cardiovasc Electrophysiol., Jul. 2011; 22(7):808-12. |
| Henz et al., “Synchronous Ventricular Pacing without Crossing the Tricuspid Valve or Entering the Coronary Sinus—Preliminary Results,” J Cardiovasc Electrophysiol., Dec. 2009; 20(12):1391-1397. |
| Hiippala et al., “Automatic Atrial Threshold Measurement and Adjustment in Pediatric Patients,” Pacing Clin Electrophysiol., Mar. 2010; 33(3):309-13. |
| Ho, “Letter to the Editor” J Cardiovasc Electrophysiol., Mar. 2010; 21(3): E76. |
| Höijer et al., “Improved cardiac function and quality of life following upgrade to dual chamber pacing after long-term ventricular stimulation,” European Heart Journal, Mar. 2002; 23(6):490-497. |
| Huang et al., “A Novel Pacing Strategy With Low and Stable Output: Pacing the Left Bundle Branch Immediately Beyond the Conduction Block,” Can J Cardiol., Dec. 2007; Epub Sep. 22, 2017; 33(12):1736.e1-1736.e. |
| Inter-Office Memo, Model 6426-85 Canine Feasibility AV Septal 8 mm Screw-In Right Single Pass DDD Lead Final Report (AR #0120A0207). |
| Ishigaki et al., “Prevention of immediate recurrence of atrial fibrillation with low-dose landiolol after radiofrequency catheter ablation,” Journal of Arrhythmia, Oct. 2015; 31(5):279-285. |
| Israel, “The role of pacing mode in the development of atrial fibrillation,” Europace, Feb. 2006; 8(2):89-95. |
| Janion et al., “Dispersion of P wave duration and P wave vector in patients with atrial septal aneurysm,” Europace, Jul. 2007; 9(7):471-4. |
| Kabra et al., “Recent Trends in Imaging for Atrial Fibrillation Ablation,” Indian Pacing and Electrophysiology Journal, 2010; 10(5):215-227. |
| Kalbfleisch et al., “Catheter Ablation with Radiofrequency Energy: Biophysical Aspects and Clinical Applications,” Journal of Cardiovascular Electrophysiology, Oct. 2008; 3(2):173-186. |
| Katritsis et al., “Classification and differential diagnosis of atrioventricular nodal re-entrant tachycardia,” Europace, Jan. 2006; 8(1):29-36. |
| Katritsis et al., “Anatomically left-sided septal slow pathway ablation in dextrocardia and situs inversus totalis,” Europace, Aug. 2008; 10(8):1004-5. |
| Khairy et al., “Cardiac Arrhythmias in Congenital Heart Diseases,” Indian Pacing and Electrophysiology Journal, Nov.-Dec. 2009; 9(6):299-317. |
| Kimmel et al., “Single-site ventricular and biventricular pacing: investigation of latest depolarization strategy,” Europace, Dec. 2007; 9(12):1163-1170. |
| Knackstedt et al., “Electro-anatomic mapping systems in arrhythmias,” Europace, Nov. 2008; 10 Suppl 3:iii28-iii34. |
| Kobayashi et al., “Successful Ablation of Antero-septal Accessory Pathway in the Non-Coronary Cusp in a Child,” Indian Pacing and Electrophysiology Journal, 2012; 12(3):124-130. |
| Kojodjojo et al., “4:2:1 conduction of an AF initiating trigger,” Indian Pacing and Electrophysiology Journal, Nov. 2015; 15(5):255-8. |
| Kolodzińska et al., “Differences in encapsulating lead tissue in patients who underwent transvenous lead removal,” Europace, Jul. 2012; 14(7):994-1001. |
| Konecny et al., “Synchronous intra-myocardial ventricular pacing without crossing the tricuspid valve or entering the coronary sinus,” Cardiovascular Revascularization Medicine, 2013; 14:137-138. |
| Kriatselis et al., “Ectopic atrial tachycardias with early activation at His site: radiofrequency ablation through a retrograde approach,” Europace, Jun. 2008; 10(6):698-704. |
| Lalu et al., “Ischaemia-reperfusion injury activates matrix metalloproteinases in the human heart,” Eur Heart J., Jan. 2005; 26(1):27-35. |
| Laske et al., “Excitation of the Intrinsic Conduction System Through His and Interventricular Septal Pacing,” Pacing Clin. Electrophysiol., Apr. 2006; 29(4):397-405. |
| Leclercq, “Problems and troubleshooting in regular follow-up of patients with cardiac resynchronization therapy,” Europace, Nov. 2009; 11 Suppl 5:v66-71. |
| Lee et al., “An unusual atrial tachycardia in a patient with Friedreich ataxia,” Europace, Nov. 2011; 13(11):1660-1. |
| Lee et al., “Blunted Proarrhythmic Effect of Nicorandil in a Langendorff-Perfused Phase-2 Myocardial Infarction Rabbit Model,” Pacing Clin Electrophysiol., Feb. 2013; 36(2):142-51. |
| Lemay et al., “Spatial dynamics of atrial activity assessed by the vectorcardiogram: from sinus rhythm to atrial fibrillation,” Europace, Nov. 2007; 9 Suppl 6:vi109-18. |
| Levy et al., “Does the mechanism of action of biatrial pacing for atrial fibrillation involve changes in cardiac haemodynamics? Assessment by Doppler echocardiography and natriuretic peptide measurements,” Europace, Apr. 2000; 2(2):127-35. |
| Lewalter et al., “Comparison of spontaneous atrial fibrillation electrogram potentials to the P wave electrogram amplitude in dual chamber pacing with unipolar atrial sensing,” Europace, Apr. 2000; 2(2):136-40. |
| Liakopoulos et al., “Sequential deformation and physiological considerations in unipolar right and left ventricular pacing,” European Journal of Cardio-thoracic Surgery, Apr. 1, 2006; 29S1:S188-197. |
| Lian et al., “Computer modeling of ventricular rhythm during atrial fibrillation and ventricular pacing,” IEEE Transactions on Biomedical Engineering, Aug. 2006; 53(8):1512-1520. |
| Lim et al., “Right ventricular lead implantation facilitated by a guiding sheath in a patient with severe chamber dilatation with tricuspid regurgitation,” Indian Pacing and Electrophysiology Journal, Sep. 2011; 11(5):156-8. |
| Lim et al., “Coupled pacing improves left ventricular function during simulated atrial fibrillation without mechanical dyssynchrony,” Europace, Mar. 2010; 12(3):430-6. |
| Lou et al., “Tachy-brady arrhythmias: The critical role of adenosine-induced sinoatrial conduction block in post-tachycardia pauses,” Heart Rhythm., Jan. 2013; 10(1):110-8. |
| Lutomsky et al., “Catheter ablation of paroxysmal atrial fibrillation improves cardiac function: a prospective study on the impact of atrial fibrillation ablation on left ventricular function assessed by magnetic resonance imaging,” Europace, May 2008; 10(5):593-9. |
| Macedo et al., “Septal accessory pathway: anatomy, causes for difficulty, and an approach to ablation,” Indian Pacing and Electrophysiology Journal, Jul. 2010; 10(7):292-309. |
| Mafi-Rad et al., “Feasibility and Acute Hemodynamic Effect of Left Ventricular Septal Pacing by Transvenous Approach Through the Interventricular Septum,” Circ Arrhythm Electrophysoil., Mar. 2016; 9(3):e003344. |
| Mani et al., “Dual Atrioventricular Nodal Pathways Physiology: A Review of Relevant Anatomy, Electrophysiology, and Electrocardiographic Manifestations,” Indian Pacing and Electrophysiology Journal, Jan. 2014; 14(1):12-25. |
| Manios et al., “Effects of successful cardioversion of persistent atrial fibrillation on right ventricular refractoriness and repolarization,” Europace, Jan. 2005; 7(1):34-9. |
| Manolis et al., “Prevention of atrial fibrillation by inter-atrial septum pacing guided by electrophysiological testing, in patients with delayed interatrial conduction,” Europace, Apr. 2002; 4(2):165-174. |
| Marino et al., “Inappropriate mode switching clarified by using a chest radiograph,” Journal of Arrhythmia, Aug. 2015; 31(4):246-248. |
| Markowitz et al., “Time course and predictors of autonomic dysfunction after ablation of the slow atrioventricular nodal pathway,” Pacing Clin Electrophysiol., Dec. 2004; 27(12):1638-43. |
| Marshall et al., “The effects of temperature on cardiac pacing thresholds,” Pacing Clin Electrophysiol., Jul. 2010; 33(7):826-833. |
| McSharry et al., “A Dynamical Model for Generating Synthetic Electrocardiogram Signals,” IEEE Transactions on Biomedical Engineering, Mar. 2003; 50(3):289-294. |
| Meijler et al., “Scaling of Atrioventricular Transmission in Mammalian Species: An Evolutionary Riddle!,” Journal of Cfardiovascular Electrophysiology, Aug. 2002; 13(8):826-830. |
| Meiltz et al., “Permanent form of junctional reciprocating tachycardia in adults: peculiar features and results of radiofrequency catheter ablation,” Europace, Jan. 2006; 8(1):21-8. |
| Mellin et al., “Transient reduction in myocardial free oxygen radical levels is involved in the improved cardiac function and structure after long-term allopurinol treatment initiated in established chronic heart failure,” Eur Heart J., Aug. 2005; 26(15):1544-50. |
| Mestan et al., “The influence of fluid and diuretic administration on the index of atrial contribution in sequentially paced patients,” Europace, Apr. 2006; 8(4):273-8. |
| Metin et al., “Assessment of the P Wave Dispersion and Duration in Elite Women Basketball Players,” Indian Pacing and Electrophysiology Journal, 2010; 10(1):11-20. |
| Mills et al., “Left Ventricular Septal and Left Ventricular Apical Pacing Chronically Maintain Cardiac Contractile Coordination, Pump Function and Efficiency,” Circ Arrhythm Electrophysoil., Oct. 2009; 2(5):571-579. |
| Mitchell et al., “How do atrial pacing algorithms prevent atrial arrhythmias?” Europace, Jul. 2004; 6(4):351-62. |
| Mirzoyev et al., “Embryology of the Conduction System for the Electrophysiologist,” Indian Pacing and Electrophysiology Journal, 2010; 10(8):329-338. |
| Modre et al., “Noninvasive Myocardial Activation Time Imaging: A Novel Inverse Algorithm Applied to Clinical ECG Mapping Data,” IEE Transactions on Biomedical Engineering, Oct. 2002; 49(10):1153-1161. |
| Montgomery et al., “Measurement of diffuse ventricular fibrosis with myocardial T1 in patients with atrial fibrillation,” J Arrhythm., Feb. 2016; 32(1):51-6. |
| Mulpuru et al., “Synchronous ventricular pacing with direct capture of the atrioventricular conduction system: Functional anatomy, terminology, and challenges,” Heart Rhythm, Nov. 2016; Epub Aug. 3, 2016; 13(11):2237-2246. |
| Musa et al., “Inhibition of Platelet-Derived Growth Factor-AB Signaling Prevents Electromechanical Remodeling of Adult Atrial Myocytes that Contact Myofibroblasts,” Heart Rhythm, Jul. 2013; 10(7):1044-1051. |
| Nagy et al., “Wnt-11 signalling controls ventricular myocardium development by patterning N-cadherin and β-catenin expression,” Cardiovascular Research, Jan. 2010; 85(1):100-9. |
| Namboodiri et al., “Electrophysiological features of atrial flutter in cardiac sarcoidosis: a report of two cases,” Indian Pacing and Electrophysiology Journal, Nov. 2012; 12(6):284-9. |
| Nanthakumar et al., “Assessment of accessory pathway and atrial refractoriness by transesophageal and intracardiac atrial stimulation: An analysis of methodological agreement,” Europace, Jan. 1999; 1(1):55-62. |
| Neto et al., “Temporary atrial pacing in the prevention of postoperative atrial fibrillation,” Pacing Clin Electrophysiol., Jan. 2007; 30(Suppl 1):S79-83. |
| Nishijima et al., “Tetrahydrobiopterin depletion and NOS2 uncoupling contribute to heart failure-induced alterations in atrial electrophysiology,” Cardiovasc Res., Jul. 2011; 91(1):71-9. |
| Niwano et al., “Effect of oral L-type calcium channel blocker on repetitive paroxysmal atrial fibrillation: spectral analysis of fibrillation waves in the Holter monitoring,” Europace, Dec. 2007; 9(12):1209-1215. |
| Okumura et al., “Effects of a high-fat diet on the electrical properties of porcine atria,” Journal of Arrhythmia, Dec. 2015; 31(6):352-358. |
| Olesen et al., “Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation,” Cardiovascular Research, Mar. 2011; 89(4):786-93. |
| Ozmen et al., “P wave dispersion is increased in pulmonary stenosis,” Indian Pacing and Electrophysiology Journal, Jan. 2006; 6(1):25-30. |
| Packer et al., “New generation of electro-anatomic mapping: Full intracardiac image integration,” Europace, Nov. 2008; 10 Suppl 3:iii35-41. |
| Page et al., “Ischemic ventricular tachycardia presenting as a narrow complex tachycardia,” Indian Pacing and Electrophysiology Journal, Jul. 2014; 14(4):203-210. |
| Pakarinen et al., “Pre-implant determinants of adequate long-term function of single lead VDD pacemakers,” Europace, Apr. 2002; 4:137-141. |
| Patel et al., “Atrial Fibrillation after Cardiac Surgery: Where are we now?” Indian Pacing and Electrophysiology Journal, Oct.-Dec. 2008; 8(4):281-291. |
| Patel et al., “Successful ablation of a left-sided accessory pathway in a patient with coronary sinus atresia and arteriovenous fistula: clinical and developmental insights,” Indian Pacing and Electrophysiology Journal, Mar. 2011; 11(2):43-49. |
| Peschar et al., “Left Ventricular Septal and Apex Pacing for Optimal Pump Function in Canine Hearts,” J Am Coll Cardiol., Apr. 2, 2003; 41(7):1218-1226. |
| Physiological Research Laboratories, Final Report for an Acute Study for Model 6426-85 AV Septal Leads, Feb. 1996. |
| Porciani et al., “Interatrial septum pacing avoids the adverse effect of interatrial delay in biventricular pacing: an echo-Doppler evaluation,” Europace, Jul. 2002; 4(3):317-324. |
| Potse et al., “A Comparison of Monodomain and Bidomain Reaction-Diffusion Models for Action Potential Propagation in the Human Heart,” IEEE Transactions on Biomedical Engineering, Dec. 2006; 53(12 Pt 1):2425-35. |
| Prystowsky et al., “Case studies with the experts: management decisions in atrial fibrillation,” J Cardiovasc Electrophysiol., Feb. 2008; 19(Suppl. 1):S1-12. |
| Prystowsky, “The history of atrial fibrillation: the last 100 years,” J Cardiovasc Electrophysiol, Jun. 2008; 19(6):575-582. |
| Pytkowski et al., “Paroxysmal atrial fibrillation is associated with increased intra- atrial conduction delay,” Europace, Dec. 2008; 10(12):1415-20. |
| Qu et al., “Dynamics and cardiac arrhythmias,” J Cardiovasc Electrophysiol., Sep. 2006; 17(9):1042-9. |
| Ravens et al., “Role of potassium currents in cardiac arrhythmias,” Europace, Oct. 2008; 10(10):1133-7. |
| Ricci et al., Efficacy of a dual chamber defibrillator with atrial antitachycardia functions in treating spontaneous atrial tachyarrhythmias in patients with life-threatening ventricular tachyarrhythmias, European Heart Journal, Sep. 2002; 23(18):1471-9. |
| Roberts-Thomson et al., “Focal atrial tachycardia II: management,” Pacing Clin Electrophysiol., Jul. 2006; 29(7):769-78. |
| Rossi et al., “Endocardial vagal atrioventricular node stimulation in humans: reproducibility on 18-month follow-up,” Europace, Dec. 2010; 12(12):1719-24. |
| Rouzet et al., “Contraction delay of the RV outflow tract in patients with Brugada syndrome is dependent on the spontaneous ST-segment elevation pattern,” Heart Rhythm, Dec. 2011; 8(12):1905-12. |
| Russo et al., “Atrial Fibrillation and Beta Thalassemia Major: The Predictive Role of the 12-lead Electrocardiogram Analysis,” Indian Pacing and Electrophysiology Journal, May 2014; 14(3):121-32. |
| Ryu et al., “Simultaneous Electrical and Mechanical Mapping Using 3D Cardiac Mapping System: Novel Approach for Optimal Cardiac Resynchronization Therapy,” Journal of Cardiovascular Electrophysiology, Feb. 2010, 21(2): 219-22. |
| Sairaku et al., “Prediction of sinus node dysfunction in patients with persistent atrial flutter using the flutter cycle length,” Europace, Mar. 2012; 14(3):380-7. |
| Santini et al., “Immediate and long-term atrial sensing stability in single-lead VDD pacing depends on right atrial dimensions,” Europace, Oct. 2001; 3(4):324-31. |
| Saremi et al., “Cardiac Conduction System: Delineation of Anatomic Landmarks With Multidetector CT,” Indian Pacing and Electrophysiology Journal, Nov. 2009; 9(6):318-33. |
| Saremi et al., “Septal Atrioventricular Junction Region: Comprehensive Imaging in Adults,” RadioGraphics, 2016, 36:1966-1986. |
| Savelieva et al., “Anti-arrhythmic drug therapy for atrial fibrillation: current anti-arrhythmic drugs, investigational agents, and innovative approaches,” Europace, Jun. 2008, 10(6):647-665. |
| Schmidt et al., “Navigated DENSE strain imaging for post-radiofrequency ablation lesion assessment in the swine left atria,” Europace, Jan. 2014; 16(1):133-41. |
| Schoonderwoerd et al., “Rapid Pacing Results in Changes in Atrial but not in Ventricular Refractoriness,” Pacing Clin Electrophysiol., Mar. 2002; 25(3):287-90. |
| Schoonderwoerd et al., “Atrial natriuretic peptides during experimental atrial tachycardia: role of developing tachycardiomyopathy,” J Cardiovasc Electrophysiol., Aug. 2004; 15(8):927-32. |
| Number | Date | Country | |
|---|---|---|---|
| 20220111216 A1 | Apr 2022 | US |
| Number | Date | Country | |
|---|---|---|---|
| 62647441 | Mar 2018 | US |
| Number | Date | Country | |
|---|---|---|---|
| Parent | 16361996 | Mar 2019 | US |
| Child | 17558832 | US |
