Claims
- 1. A compound according to formula (I): or a pharmaceutically acceptable salt thereof.
- 2. A compound according to claim 1 in which Y is wherein R′ is H, C1-4alkyl, OC1-4alkyl, SC1-4alkyl, NR″R″ or Cl and each R″ independently is H or C1-4alkyl.
- 3. A compound according to claim 1 in which Y is wherein each R″ is H or C1-4alkyl.
- 4. A compound according to claim 1 in which Y is wherein R″ is H or C1-4alkyl.
- 5. A compound according to claim 1 which is:(±)-10,11-Dihydro-3-[2-(6-aminopyridin-2-yl)-1-ethoxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (±)-10,11-Dihydro-3-[4-(pyridin-2-ylamino)-1-butyl]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (±)-10,11-Dihydro-3-[3-(4-ethoxypyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (S)-10,11-Dihydro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (R)-10,11-Dihydro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (±)-10,11-Dihydro-3-[3-(isoquinoline-1-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (±)-10,11-Dihydro-7-fluoro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (S)-10,11-Dihydro-3-[3-(4-methylpyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (S)-10,11-Dihydro-3-[3-(4-ethoxypyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (±)-10,11-Dihydro-6-methyl-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (±)-10,11-Dihydro-2-(dimethylamino)methyl-7-fluoro-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (S)-10,11-Dihydro-3-[3-[4-(2-propyloxy)pyridin-2-ylamino]-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (S)-10,11-Dihydro-3-[2-[6-(methylamino)pyridin-2-yl]-1-ethoxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (S)-10,11-Dihydro-3-[3-[4-(dimethylamino)pyridin-2-ylamino]-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (±)-10,11-Dihydro-3-[3-[4-(ethylthio)pyridin-2-ylamino]-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (S)-10,11-Dihydro-3-[3-(4-chloropyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (±)-10,11-Dihydro-2-methyl-3-[3-(pyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (S)-10,11-Dihydro-3-[3-(4-aminopyridin-2-ylamino)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; (±)-10,11-Dihydro-3-[3-(4-methylpyridin-2-ylamino)-1-propyloxy]-dibenzo[b,f]oxepine-10-acetic acid; (±)-10,11-Dihydro-3-[2-[6-(methylamino)pyridin-2-yl]-1-ethoxy]-dibenzo[b,f]oxepine-10-acetic acid; or (S)-10,11-Dihydro-3-[3-(2-aminopyridin-4-yl)-1-propyloxy]-5H-dibenzo[a,d]cycloheptene-10-acetic acid; or a pharmaceutically acceptable salt thereof.
- 6. A pharmaceutical composition which comprises a compound according to claim 1 and a pharmaceutically acceptable carrier.
- 7. A pharmaceutical composition which comprises a compound according to claim 1, an antineoplastic agent and a pharmaceutically acceptable carrier.
- 8. The pharmaceutical composition according to claim 7 wherein the antineoplastic agent is topotecan.
- 9. The pharmaceutical composition according to claim 7 wherein the antineoplastic agent is cisplatin.
- 10. A compound according to formula (II): or a pharmaceutically acceptable salt thereof.
Parent Case Info
This is a continuation of application Ser. No. 09/508,574 filed Mar. 13, 2000 which is a 371 application of PCT/US98/19466 filed Sep. 18, 1998 which claims the benefit of provisional applications 60/059,342 filed Sep. 19, 1997 and 60/063,438 filed Oct. 29, 1997.
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Provisional Applications (2)
|
Number |
Date |
Country |
|
60/063438 |
Oct 1997 |
US |
|
60/059342 |
Sep 1997 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09/508574 |
|
US |
Child |
10/022987 |
|
US |