Claims
- 1. Anhydrous antifingal gel compositions comprising at least one polyhydric alcohol, a gelling agent and an antifungal azole compound.
- 2. A composition according to claim 1 wherein said antifungal compound comprises an imidazoles compound.
- 3. A composition according to claim 2 where the imidazoles compound is selected from the group consisting of econazole, terconazole, saperconazole, itraconazole, butaconazole, clotrimazole, tioconazole, fluconazole and ketoconazole, vericonazole, fenticonazole, sertaconazole, posaconazole, bifonazole, oxiconazole, sulconazole, elubiol, vorconazole, isoconazole, flutrimazole, tioconazole and their pharmaceutically acceptable salts.
- 4. A composition according to claim 1 where the composition further comprises a pH adjustment agent.
- 5. A composition according to claim 1 wherein said polyhydric alcohol is selected from the group consisting of: glycerin, alkylene glycol, polyethylene glycol and a mixture thereof.
- 6. A composition according to claim 1 wherein the said gelling agent is hydroxypropylcellulose.
- 7. A composition according to claim 4 where the pH adjustment agent is an organic acid.
- 8. A composition according to claim 7 wherein said organic acid is an alphahydroxy acid.
- 9. A composition according to claim 8 wherein said alphahydroxy acid is Lactic Acid.
- 10. A composition according to claim 5 wherein said polyethylene glycol is selected from the group consisting of: polyethylene glycol 300, polyethylene glycol 400 and a mixture thereof.
- 11. A composition according to claim 1 wherein the said composition comprises from about 75% to about 99% by weight of polyhydric alcohol, from about 0.1% to about 4% of hydroxypropylcellulose, from about 0.1% to about 1% by weight of lactic acid, and from about 0.25% to about 20% by weight of an antifungal agent.
- 12. A composition according to claim 1 where the composition is a clear transparent gel.
- 13. A method of treating vulvovaginal candidiasis comprising administering to a patient in need thereof a composition according to claim 1.
- 14. A method of treating bacterial vaginosis comprising administering to a patient in need thereof a composition according to claim 1.
- 15. A method of treating a patient with both vulvovaginal candidiasis and bacterial vaginosis comprising administering to said patient a composition according to claim 1.
- 16. A composition according to claim 7 where the composition adjust the pH of the vagina to an acidic pH between about 2 and about 5.
- 17. A method of treating a patient with both oral fungal and bacterial infections comprising administering to said patient a composition according to claim 1.
- 18. A method of treating a patient with both nail fungal and bacterial infections comprising administering to said patient a composition according to claim 1.
Parent Case Info
[0001] This application is a continuation-in-part of patent application U.S. Ser. No. 10/137,509 and co-pending patent application Ser. No. ______ (Attorney Docket No. PPC 834 CIP) which are hereby incorporated herein by reference.
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
10137509 |
May 2002 |
US |
Child |
10389871 |
Mar 2003 |
US |