The present invention concerns a device for washing the injector in a liquid chromatography analysis equipment.
In modern chromatographic analysis equipments it is increasingly important to be sure of introducing into the chromatograph samples, generally in very small quantities, without any contamination, in particular contamination due to samples previously analysed. To ensure this, it is important, before each analysis, to wash the sample introduction equipment and the injection device in general.
A device of this type has already been proposed for HPLC (High Pressure Liquid Chromatography) injectors, described in EP 1275957 and U.S. Pat. No. 6,526,812. This device consists essentially of a body with an internal chamber which can be connected to a source of washing fluid and which can be accessed via an injection needle which is inserted through a duct external to the chamber and passing through the chamber until it reaches a passage for injection of the samples. This passage is shaped so as to provide a seal on the outer surface of the needle, obviously when the latter is inserted during use.
The duct for insertion of the needle is obtained in a fixed part of the device, upstream of said chamber, with the positioning of a seal that can be penetrated by the needle between said duct and the chamber. Again according to the patents referred to, the penetrable seal is made of an elastic material (elastomer) and can be a so-called duckbill valve or a piercable partition. Lastly, it is possible to perform washing with different fluids, present in different containers that can be selected with one or more valves.
This embodiment has some problems at operating level as the duckbill valves have a limited working life and, like the partitions, can release downstream particles that have been detached during insertion of the needle; these particles are obviously contaminating and could obstruct the ducts of the fluid circuit. Furthermore, there could be chemical incompatibilities between the elastomeric materials and the solvents used for the washing.
To avoid these and other drawbacks connected in particular with the use of a piercable elastomer seal, the invention proposes a washing device for injectors in liquid chromatography equipments having the characteristics of claim 1.
The invention will now be described with reference to a preferred embodiment, illustrated by way of example in the accompanying drawings, in which:
With reference firstly to
In its lower part, the block 12 is seal-connected 20 to an elongated component 18 which contains, inside, a passage 24 for the needle or other injection means, aligned with the upper duct. The lower part of the passage 24, indicated by 22, is provided internally with a coating designed to provide a seal with the outer surface of the needle or similar injection device, in a known manner, obviously when said needle is present.
Upstream of the passage 22, 24, the block 12 has a short duct 26 connected and aligned with said passage 22, 24, which ends, like the duct 14, in a valve seat 28, for example a cylindrical, are obtained in the block 12. Inside said valve seat 28 a valve body 30, also cylindrical, is seal-fitted, arranged rotating around its axis to be set to a plurality of positions, in this case two positions, in which two different ways 32 and 34 obtained in the valve body are provided to define two different connections.
The block 12 has a duct 36 which leads at one end to the valve seat 28 and at the other is connected to a tank 38 containing a washing fluid 40.
When the valve body 30 is arranged in the position illustrated in
In the injection position of
In the subsequent phase, illustrated in
In the position illustrated of the valves 28, 30 and 42, the washing suction micropump 46 is connected to the outlet of the passage 22, 24, and the latter is fed with the washing fluid coming from the tank 38, as schematised in
If several washing fluids are required, for use alternatively or in succession, the valve body 30 is modified in order to provide for example three (or more) ways with three or more operating positions, so that washing fluid can be drawn both from the duct 36 (
In the case of two different washing fluids,
Alternatively washing with several fluids can be provided by including a further multi-position selector valve upstream of the washing device.
Filing Document | Filing Date | Country | Kind | 371c Date |
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PCT/IT2006/000644 | 9/6/2006 | WO | 00 | 8/27/2008 |