Claims
- 1. A biologically active slow release composition which comprises a homogenous mixture of a water soluble carbohydrate polymer or a water dispersible carbohydrate polymer, a growth promoting effective amount or a milk production enhancing effective amount of a biologically active macromolecule and an aqueous or a pharmaceutically acceptable water miscible organie solvent; wherein said macromolecule is a growth hormone, a somatomedin or a biologically active fragment thereof; with the proviso that the weight ratio of the carbohydrate polymer to said macromolecule is in the range of 0.25:1.0 to 100:1.0 and the weight ration of the aqueous or pharmaceutically acceptable water miscible solvent to carbohydrate polymer is in the range of 0.83:1.0 to 50:1.0.
- 2. The composition according to claim 1, wherein the biologically active macromolecule is bound to the carbohydrate polymer forming a complex.
- 3. The composition according to claim 2, wherein the mixture further contains a hydrophobic dissociating substance or a hydrophilic dissociating substance.
- 4. The composition according to claim 1, wherein the solvent is an aqueous buffered solution or saline.
- 5. The composition according to claim 2, 3 or 4, wherein the carbohydrate is starch or dextran.
- 6. The composition according to claim 4, wherein the carbohydrate polymer is dextran, dextrin, alginate, starch, fractionated starch, glycogen, pullullan, agarose, cellulose, chitosan, carrageenan, synthetic biopolymer, xanthan gum, guar gum, locust bean gum, gum arabic, tragacanth gum, karaya gum or a mixture thereof; and the growth hormone is bovine growth hormone, ovine growth hormone, equine growth hormone or porcine growth hormone.
- 7. The composition according to claim 6, wherein the carbohydrate polymer is dextrin; the growth hormone is bovine growth hormone and the solvent is water or an aqueous buffered solution.
- 8. The composition according to claim 6, wherein the carbohydrate polymer is a heteropolysaccharide of glucose, galactose, mannose, glucuronic acid and fucose and the growth hormone is bovine growth hormone.
- 9. The composition according to claim 6, wherein the mixture of carbohydrate polymers is a mixture of xanthan gum and locust bean gum and hormone.
- 10. A biologically active slow release composition which comprises an aqueous solution, a complex of a growth promoting effective amount or a milk production enhancing effective amount of a biologically active macromolecule selected from the group consisting of a growth hormone, a somatomedin and a biologically active fragment thereof bound to a water soluble or water dispersible carbohydrate polymer; with the proviso that the weight ratio of the carbohydrate polymer to said macromolecule is in the range of 0.25:1.0 to 100:1.0 and the weight ratio of the water of the aqueous solution to carbohydrate polymer is in the range of 0.83:1.0 to 50:1.0.
- 11. A method of preparing a biologically active slow release composition comprising mixing a growth promoting effective amount or a milk production enhancing effective amount of a biologically active macromolecule selected from the group consisting of a growth hormone, a somatomedin and a biologically active fragment thereof with a water soluble or water dispersible carbohydrate polymer in an aqueous solvent without forming a covalent bond between said biologically active macromolecule and said carbohydrate polymer, wherein the weight ratio of the carbohydrate polymer to said macromolecule is in the range of 0.25:1.0 to 100:1.0 and the weight ratio of the aqueous solvent to carbohydrate polymer is in the range of 0.83:1.0 to 50:1.0, thereby obtaining a homogenous mixture.
- 12. The method according to claim 11, further comprising the step of adding a hydrophobic dissociating substance or a hydrophilic dissociating substance in the mixing step when said mixing step creates a noncovalent bond between the biologically active macromolecule and the carbohydrate polymer.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8501094 |
Mar 1985 |
SEX |
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Parent Case Info
This application is a continuation of co-pending application Ser. No. 06/830,158, filed on Feb. 20, 1986, now abandoned, which is a continuation-in-part of prior application Ser. No. 06/717,417, filed on Mar. 29, 1985, abandoned.
US Referenced Citations (11)
Foreign Referenced Citations (8)
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085036 |
Aug 1983 |
EPX |
94157 |
Nov 1983 |
EPX |
94157 |
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EPX |
123291 |
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8400294 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
830158 |
Feb 1986 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
717417 |
Mar 1985 |
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