Claims
- 1. Water soluble antitumor analogs of paclitaxel having the following formula: wherein:R1=C(O)CH2CH(OH)COOX, R2=H, C(O)CH2CH(OH)COOX, X=H, Li, Na or any other pharmaceutically acceptable counterion.
- 2. A pharmaceutical composition comprising an antineoplastically effective amount of the analog of claim 1 as an active ingredient, and pharmaceutically acceptable carrier, optionally in combination with further additives.
- 3. A method for the treatment of tumours comprising administering an effective amount of the analog as defined in claim 1.
- 4. A method in accordance with claim 3, wherein said tumour is a mammary carcinoma or a colon tumour.
Parent Case Info
This application is a continuation of PCT/NL98/00473 dated Aug. 21, 1998.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5059699 |
Kingston et al. |
Oct 1991 |
A |
Foreign Referenced Citations (1)
Number |
Date |
Country |
9405282 |
Mar 1994 |
WO |
Non-Patent Literature Citations (1)
Entry |
Damen et al, Bioorg. Med. Chem., 8(2), pp. 427-432, 2000. |
Continuations (1)
|
Number |
Date |
Country |
Parent |
PCT/NL98/00473 |
Aug 1998 |
US |
Child |
09/788344 |
|
US |