Water-soluble polymers and their use in cosmetic and pharmaceutical preparations

Abstract

A description is given of cosmetic and pharmaceutical preparations comprising I) one or more water-soluble noncrosslinked copolymers containingA) one or more structural units of the formula (1)

Description

EXAMPLES AND APPLICATIONS

1) Preparation of Macromonomers

Version 1: Glycidyl Methacrylate

A one-liter three-neck flask with stirrer, internal thermometer, and reflux condenser is charged with 600 g of Genapol® T-250 and 75 g of glycidyl methacrylate are added. Subsequently the reaction mixture is heated at 100° C. for 2 hours and the excess glycidyl methacrylate is distilled off under reduced pressure. The resulting macromonomer can be used without further purification for the polymerization.

Version 2: Free Meth-/Acrylic Acid

A one-liter three-neck flask with stirrer, internal thermometer, and reflux condenser is charged with 500 g of Genapol® UD-070, and 100 g of meth-/acrylic acid and p-toluenesulfonic acid catalyst are added. Subsequently the reaction mixture is boiled under reflux for 2 hours and the excess acid and the water of reaction formed are distilled off under reduced pressure. The resulting macromonomer can be used without further purification for the polymerization.

Version 3: Halogen Derivatives of Meth-/Acrylic Acid

A one-liter three-neck flask with stirrer, internal thermometer, and reflux condenser is charged with 500 g of Genapol® UD-80 containing a primary amino end group, and 110 g of meth-/acryloyl chloride and 50 g of sodium carbonate are added. Subsequently the reaction mixture is boiled under reflux for 2 hours. The cessation of CO₂ evolution indicates the end of the modification reaction. The excess acid chloride is distilled off under reduced pressure. The resulting macromonomer with a meth-/acrylamide end group can be used without further purification for the polymerization.

Version 4: Ester of Meth-/Acrylic Acid

A one-liter three-neck flask with stirrer, internal thermometer, and reflux condenser is charged with 500 g of Genapol® LA-070, and 100 g of methyl meth-/acrylate and 20 g of titanium tetraisopropoxide are added. Subsequently the reaction mixture is boiled under reflux for 2 hours. When the resulting alcohol has been removed by distillation, the remaining ester is distilled off under reduced pressure. The resulting macromonomer with a meth-/acrylic acid end group can be used without further purification for the polymerization.

2) Polymerization

General polymerization procedure for preparing the side chain polymers, used in the preparations of the invention, by the precipitation process in tert-butanol.

A 2-liter Quickfit flask with reflux condenser, gas inlet, internal thermometer, and stirrer is charged with 500 ml of tert-butanol, and the calculated amount of acryloyldimethyltaurine is added. Subsequently, neutralization is effected by introduction of NH₃, and the LCST (lower critical solution temperature) side arms prepared as under 1), i.e., the corresponding macromonomers (two or more different species also possible), are added to the reaction mixture. If further comonomers are needed, they can be added to the reaction mixture following neutralization. After the mixture has been rendered inert using N₂ or argon, AIBN (azobisisobutyronitrile) initiator is added at an internal temperature of 60° C. and the polymerization reaction is initiated. After a few minutes, the completed polymer is precipitated. The mixture is heated at reflux for two hours and the polymer is subsequently freed from the solvent on a suction filter and dried under reduced pressure. This procedure can be employed generally for all the polymerization reactions described below.

Noncrosslinked side chain polymers (polymers 1)

Example 1

Reaction as Per General Polymerization Procedure

Reactant                         Amount (g)
Macromonomer                     20
of version 1 - type Genapol ® T-250
NH3-neutralized acryloyldimethyltaurine 100
tert-Butanol                     300
AIBN (initiator)                 1

Example 2

Reaction as Per General Polymerization Procedure

Reactant                         Amount (g)
Macromonomer                     15
of version 3 - type Genapol ® UD-80
Macromonomer                     15
of version 1 - type Genapol ® T-250
NH3-neutralized acryloyldimethyitaurine 90
tert-Butanol                     300
AIBN (initiator)                 1

Example 3

Reaction as Per General Polymerization Procedure

Reactant                         Amount (g)
Macromonomer                     18
of version 4 - type Genapol ® LA-070
NH3-neutral ized acryloyldimethyltaurine 80
tert-Butanol                     300
Dilauroyl peroxide (DLP) (initiator) 2

Example 4

Reaction as Per General Polymerization Procedure

The macromonomer from Example 4 is prepared in analogy to version 1 with the difference that, instead of 600 g of Genapol® T-250, 600 g of Genapol® LA-070 are used.

Reactant                         Amount (g)
Macromonomer                     20
of version 1 - type Genapol ® LA-070
Na-neutralized acryloyldimethyltaurine 75
Acrylamide                       50
tert-Butanol                     300
AIBN (initiator)                 1

Example 5

Reaction as Per General Polymerization Procedure

The macromonomer from Example 5 is prepared in analogy to version 4 with the difference that, instead of 500 g of Genapol® LA-070, 500 g of Genapol® T-080 are used.

Reactant                         Amount (g)
Macromonomer                     18
of version 4 - type Genapol ® T-080
NH3-neutralized acryloyldimethyltaurine 80
tert-Butanol                     300
DLP (initiator)                  2

APPLICATION AND FORMULATION EXAMPLES

Aqueous refreshing gels

Examples 6 to 28

General Mode of Preparation for Refreshing Gels

Refreshing Gel

Composition

Example 7

	A	Carbopol ® 980	0.50%
		Noncrosslinked copolymer with	0.50%
		Laureth-7 MA as per Example 3
		Water	ad 100
		NIPA ® BIOPURE 100	0.30%
		NaOH (10% in water)	1.60%
Preparation
	I	Dissolution of components A

The formulations 6, and 8 to 28 were prepared in analogy to the general mode of preparation for refreshing gels (see Tables 2a and 2b).

TABLE 2a
Refreshing gels
	experiment number
	Comparative	Inventive	Inventive	Inventive	Inventive	Inventive	Inventive
	Example	Example	Example	Example	Example	Example	Example
Ingredients	6	7	8	9	10	11	12
Carbopol ®	1	0.5
980
Carbopol ®			0.5
ETD 2020
Aristoflex ®				0.3	0.7
AVC
Crosslinked						0.7
copolymer as
per Example
C from DE 10
2004 050239
Aristoflex ®							0.7
HMB
Crosslinked
copolymer as
per Example
44 from EP
1069142
Crosslinked
copolymer as
per Example 1
from
DE19625810
Noncrosslinked		0.5	0.5	0.7	0.3	0.3	0.3
copolymer
as per
Example 3
Noncrosslinked
copolymer
as per
Example 5
Water	95.5	97.05	97.1	98.7	98.7	98.7	98.7
NaOH	3.2	1.6	1.6
w = 10%
Nipa	0.3	0.3	0.3	0.3	0.3	0.3	0.3
Biopure ® 100
NaCl
Cirebelle ®				approx.
wax				0.05
Viscosity in	50 000	15 800	14 200	1050	8850	8900	8950
mPas
(at 20 rpm)
Appearance/	Clear gel,	pleasantly	pleasantly	pleasantly	pleasantly	pleasantly	pleasantly
remarks	thick,	workable	workable	workable	workable	workable	workable
	stringy,	gel, not	gel, not	gel, not	gel, not	gel, not	gel, not
	unpleasantly	sticky	sticky	sticky	sticky	sticky	sticky
	sticky
	experiment number
	Inventive	Inventive	Comparative	Comparative	Inventive	Inventive	Comparative
	Example	Example	Example	Example	Example	Example	Example
Ingredients	13	14	15	16	17	18	19
Carbopol ®			0.5
980
Carbopol ®
ETD 2020
Aristoflex ®	0.2				0.5
AVC
Crosslinked
copolymer as
per Example
C from DE 10
2004 050239
Aristoflex ®						0.5
HMB
Crosslinked	0.5
copolymer as
per Example
44 from EP
1069142
Crosslinked		0.7
copolymer as
per Example 1
from
DE19625810
Noncrosslinked	0.3	0.3		1
copolymer
as per
Example 3
Noncrosslinked					0.5	0.5	1
copolymer
as per
Example 5
Water	98.7	98.7	97.6	98.7	97.7	97.7	98.7
NaOH			1.6
w = 10%
Nipa	0.3	0.3	0.3	0.3	0.3	0.3	0.3
Biopure ® 100
NaCl
Cirebelle ®
wax
Viscosity in	8980	8950	26 600	1000	9750	9400	5100
mPas
(at 20 rpm)
Appearance/	pleasantly	pleasantly	few air	very	clear,	clear,	clear,
remarks	workable	workable	bubbles,	elastic gel	workable	workable	workable
	gel, not	gel, not	good gel	forms	gel,	gel,	gel, gel
	sticky	sticky	texture but	strings,	breaks up	breaks up	structure is
			sticky	relatively	quickly on	quickly on	relatively
				liquid	the skin,	the skin,	long lasting,
					refreshing	refreshing	forms some
							strings

TABLE 2b
Refreshing gels, continuation
	experiment number
	Inventive	Inventive	Comparative	Inventive	Comparative
	Example	Example	Example	Example	Example
Ingredients	20	21	22	23	24
Carbopol ® 980
Carbopol ® ETD 2020
Aristoflex ® AVC	0.5	0.5
Aristoflex ® HMB					1
Noncrosslinked	2	2		0.5
copolymer as per
Example 3
Noncrosslinked
copolymer as per
Example 5
Water	ad 100	ad 100	ad 100	ad 100	ad 100
NaOH w = 10%
Nipa Biopure ® 100			0.3	0.3	0.3
NaCl					0.1
Propylene glycol	2	2
Laureth-23	2	1.8
Fragrance	0.2
EtOH		20
Nipaguard ® MPA	0.5
Tylose ® H 10000 G4			1	0.5
cirebelle ® wax
Viscosity in mPas	7500	1230	700	350	4800
(at 20 rpm)
Appearance/remarks	elastic gel,	workable gel,	relatively	relatively	clear gel,
	pleasant gel	less elastic	liquid, soft	liquid,	numerous air
	texture on the	than 20	feel, slightly	pleasant gel	bubbles,
	skin		sticky	texture is long	breaks up
				lasting	very quickly
				breaks up a	on the skin
				bit more
				quickly on the
				skin than 25
	experiment number
		Comparative	Comparative	Inventive	Inventive
		Example	Example	Example	Example
	Ingredients	25	26	27	28
	Carbopol ® 980		1	0.5
	Carbopol ® ETD 2020
	Aristoflex ® AVC
	Aristoflex ® HMB				0.5
	Noncrosslinked			0.5	0.5
	copolymer as per
	Example 3
	Noncrosslinked
	copolymer as per
	Example 5
	Water	ad 100	ad 100	ad 100	ad 100
	NaOH w = 10%		3.2	1.6
	Nipa Biopure ® 100	0.3	0.3	0.3	0.3
	NaCl	0.1	0.1	0.1	0.1
	Propylene glycol
	Laureth-23
	Fragrance
	EtOH
	Nipaguard ® MPA
	Tylose ® H 10000 G4	1
	cirebelle ® wax
	Viscosity in mPas	760	39400	12200	1100
	(at 20 rpm)
	Appearance/remarks	relatively liquid,	workable gel,	workable	some air
		soft fell, slightly	sticky in	gel,	bubbles,
		sticky	comparison to	numerous	breaks up
			27	air	relatively
				bubbles,	quickly on the
				clear	skin

Hairstyling Gels

Examples 29 to 51

General Mode of Preparation for Hairstyling Gels:

Hair gel, sprayable

Composition

Example 30

	A	Aristoflex ® AVC	0.15%
		Noncrosslinked copolymer with	0.35%
		Laureth-7 MA as per Example 3
		Water	ad 100
		NIPA ® BIOPURE 100	0.30%
	B	Diaformer ® Z-651 N	4.00%
Preparation
	I	Dissolution of components A
	II	Addition of B to I.

Formulations 29 and 31 to 51 were prepared in analogy to the general mode of preparation for hairstyling gels (see Tables 3a and 3b).

TABLE 3a
Hairstyling gels
	experiment number
	Inventive	Inventive	Inventive	Comparative	Comparative	Comparative	Comparative	Inventive
	Example	Example	Example	Example	Example	Example	Example	Example
Ingredients	29	30	31	32	33	34	35	36
Aristoflex ® AVC	0.15				0.65	0.65		0.35
Crosslinked		0.15
acryloyldimethyltaurine
copolymer as per Ex. C
from DE 10 2004 050239
Aristoflex ® HMB			0.15	0.5
Noncrosslinked	0.35	0.35	0.35				0.5
copolymer as per Ex. 3
Noncrosslinked								0.15
copolymer as per Ex. 5
Water	95.2	95.2	95.2	95.2	96.05	95.05	95.2	96.2
NIPA Biopure ® 100	0.3	0.3	0.3	0.3	0.3	0.3	0.3	0.3
Eusolex ® 232 neutralized
Diaformer ® Z 651 N	4	4	4	4		4	4
Alkylpolyglycoside
(Plantacare ® 818 up)
Luviskol ® PVP K 30					3
VP/VA copolymer								3
Diaformer ® Z 712 N
Propylene glycol
Laureth23
Fragrance
EtOH
Nipaguard ® MPA
Viscosity in mPas	7750	7800	10700	8900	21700	20600	7300	3650
(at 20 rpm)
Appearance/remarks	elastic	elastic	elastic	gel,	yellow gel	rapid loss of	highly	workable
	texture,	texture,	texture,	numerous		gel texture,	stringing,	gel, air
	long-	long-	long-	air bubbles,		more watery	very elastic	bubbles,
	lasting	lasting	lasting	rapid loss of		than 30/31,		breaks
	gel	gel	gel	gel texture,		less		up quickly on
	texture	texture	texture	more watery		substance		the skin
	compared	compared	compared	than 30/31
	with 34	with 34	with 32
	experiment number
	Inventive	Inventive	Inventive	Inventive	Inventive	Inventive	Inventive	Inventive
	Example	Example	Example	Example	Example	Example	Example	Example
Ingredients	37	38	39	40	41	42	43	44
Aristoflex ® AVC		0.1		0.1	0.5	0.5		0.15
Crosslinked
acryloyldimethyltaurine
copolymer as per
Ex. C from
DE 10 2004 050239
Aristoflex ® HMB	0.35		0.1				0.7
Noncrosslinked				1.5	1	1	0.3	0.35
copolymer as per Ex. 3
Noncrosslinked	0.15	1	1
copolymer as per Ex. 5
Water	96.2	70.7	70.7				97.7	94.2
NIPA Biopure ® 100	0.3						0.3	0.3
Eusolex ® 232 neutralized							1	1
Diaformer ® Z 651 N								4
Alkylpolyglycoside
(Plantacare ® 818 up)
Luviskol ® PVP K 30
VP/VA copolymer	3
Diaformer ® Z 712 N		3.5	3.5	3.5	3.5	3.5
Propylene glycol		2	2	2	2	2
Laureth23		2	2	2	2	2
Fragrance		0.2	0.2	0.2	0.2	0.2
EtOH		20	20			10
Nipaguard ® MPA		0.5	0.5	0.5	0.5	0.5
Viscosity in mPas	2800	10800	8650	21700	25700	9250	45	25
(at 20 rpm)
Appearance/remarks	workable	elastic,	elastic,	almost rubber-	rubber-elastic	workable	gel	gel
	gel, air	relatively	relatively	elastic gel,	gel, breaks up	gel, on the	texture	texture is
	bubbles,	firm gel,	firm gel,	breaks up	quickly on the	skin as well,	breaks up	long
	breaks up	gel	gel	quickly on the	skin	gel texture	only	lasting
	quickly on	texture	texture	skin		is long	slowly
	the skin	long	long			lasting
		lasting	lasting

TABLE 3b
Hairstyling gels, continuation
	experiment number
	Comparative	Inventive	Inventive	Comparative	Inventive	Inventive	Inventive
	Example	Example	Example	Example	Example	Example	Example
Ingredients	45	46	47	48	49	50	51
Aristoflex ® AVC		0.5	0.1		0.5	0.5	0.1
Noncrosslinked	1.5	2	2	1.5	2	2	2
copolymer as per Ex. 3
Water	95.2	70	69.9	94.7	71.92	65.9	60.8
NIPA Biopure ® 100	0.3			0.3
Diaformer ® Z 651 N
VP/VA Copolymer	3	3		3	3	3
Diaformer ® Z 712 N			3.5				5
Propylene glycol		2	2		2	2	2
Laureth-23		2	2			2	2
Fragrance		0.2	0.2			0.2	0.2
EtOH		20	20		20	20	20
Nipaguard ® MPA		0.5	0.5		0.5	0.5	0.5
Genapol  ® LA 070						2	2
Silcare ® Silicone SEA						1	1
Pigment: Cloisonne					~0.04
Super Green ®
Glitter (Creasparkles					~0.04
Metallic Silver 700 ®)
Abil ® EM 90 (silicone						1	1
emulsifier)
Viscosity in mPas (at	370	2850	3840	11700	1390	9550	2120
20 rpm)
Appearance/remarks	highly fluid	gel, pleasant	firm, elastic	gel	highly fluid gel,	highly fluid	elastic gel,
	gel, stringing	on the skin,	gel, pleasant		pleasant on the	gel,	pleasant on the
		gel texture is	on the skin,		skin, gel	pleasant	skin, gel texture is
		long lasting	gel texture is		texture is long	on the	long lasting,
			long lasting,		lasting, glitter	skin, gel	shimmer effect is
			shimmer		apparent	texture is	apparent
			effect readily			long
			apparent			lasting

Mild Cleansing Gels

Examples 52 to 55

General Mode of Preparation for Mild Cleansing Gels:

Mild cleansing gel

Composition

Example 54

	A	Aristoflex ® AVC	0.30%
		Noncrosslinked copolymer with	0.70%
		Laureth-7 MA as per Example 3
		Water	ad 100%
		NIPA ® BIOPURE 100	0.30%
	B	Genapol ® LRO	25.90%
		Genagen ® CAB 818	10.00%
Preparation:
	I	Dissolution of components A
	II	Mixing of components B
	III	Addition of II to I

Formulations 52, 53 and 55 were prepared in analogy to the general mode of preparation for mild cleansing gels (see Table 4).

TABLE 4
Mild cleansing gels
	experiment number
	Inventive	Inventive	Inventive	Inventive
	Example	Example	Example	Example
Ingredients	52	53	54	55
Aristoflex ® AVC	0.3		0.3
Aristoflex ® HMB		0.3		0.3
Noncrosslinked	0.7	0.7	0.7	0.7
copolymer as per Ex. 3
Water	92.7	92.7	62.8	62.8
NIPA Biopure ® 100	0.3	0.3	0.3	0.3
Alkylpolyglycoside	6	6
(Plantacare ® 818 up)
Genapol ® LRO			25.9	25.9
Genagen ® CAB 818			10	10
Viscosity in mPas (at	2880	1615	250	1560
20 rpm)
Appearance/remarks	elastic,	elastic,	gel	gel
	gel-like	gel-like

Sunscreen Gels

Examples 56 to 61

General Mode of Preparation for Sunscreen Gels:

Sunscreen gel

Composition

Example 60

A	Eusolex ® 232	1.00%
	Water	ad 100%
	NIPA ® BIOPURE 100	0.30%
B	Aristoflex ® AVC	0.70%
	Noncrosslinked copolymer with	0.30%
	Steareth-8 MA as per Example 5
Preparation
I	Mixing of components A and adjustment to pH 7.3
	with tris(hydroxymethyl)aminomethane
II	Successive addition of components B to I.

Formulations 56 to 59 and 61 were prepared in analogy to the general mode of preparation for sunscreen gels (see Table 5).

TABLE 5
Sunscreen gels
	experiment number
	Comparative	Inventive	Inventive	Inventive	Inventive	Inventive
	Example	Example	Example	Example	Example	Example
Ingredients	56	57	58	59	60	61
Aristoflex ® AVC		0.3		0.7	0.7
Aristoflex ® HMB			0.3			0.7
Noncrosslinked copolymer as	1	0.7	0.7	0.3
per Ex. 3
Noncrosslinked copolymer as					0.3	0.3
per Ex. 5
Water	97.7	97.7	97.7	97.7	97.7	97.7
NIPA Biopure ® 100	0.3	0.3	0.3	0.3	0.3	0.3
Eusolex ® 232 neutralized	1	1	1	1	1	1
Viscosity in mPas (at 20 rpm)	4350	2920	1610	945	460	60
Appearance/remarks	stringing,	more pleasant	more pleasant	pleasant on the	pleasant on	pleasant on
	sticks readily	texture than 56	texture than 56	skin	the skin	the skin
	when dry

Styling Creams

Examples 62 to 72

General Mode of Preparation for Styling Creams:

Styling cream

Composition

Example 62

	A	Mineral oil, low-viscosity	1.00%
		Cetiol ® 868	1.00%
		SilCare ® 15M50	1.50%
		Hostaphat ® KL 340 D	1.00%
	B	Aristoflex ® AVC	1.05%
		Noncrosslinked copolymer with	0.45%
		Laureth-7 MA as per Example 3
	C	Water	ad 100.00%
		Glycerol	3.00%
		Phenonip ®	0.40%
	D	Diaformer ® Z 711 N	3.00%
Preparation
	I	Mixing of A and B
	II	Stirred incorporation of C into I
	III	Stirred incorporation of D into II
	IV	Homogenizing

Formulations 63 to 72 were prepared in analogy to the general mode of preparation for styling creams (see Table 6).

TABLE 6
Styling creams
	experiment number
	Inventive	Inventive	Inventive	Inventive	Comparative	Comparative
	Example	Example	Example	Example	Example	Example
Ingredients	62	63	64	65	66	67
Aristoflex ® AVC	1.05	0.45	1.05	1.05
Aristoflex ® HMB
Noncrosslinked	0.45	1.05	0.45	0.45	1	1
copolymer as per Ex. 3
Water	87.6	87.6	87.6	87.6	88.1	88.1
VP/VA Copolymer						3
Liquid paraffin	1	1	1	1	1	1
Cetiol ® 868	1	1	1	1	1	1
Silcare ® 15M50	1.5	1.5	1.5	1.5	1.5	1.5
Tegin ® M			0.3	0.3	1	1
Hostaphat ® KL 340 D	1	1	0.7
Phenonip ®	0.4	0.4	0.4	0.4	0.4	0.4
Glycerol	3	3	3	3	3	3
Diaformer ® Z 711 N	3	3	3	3	3
Hostacerin ® DGL				0.7
Hostacerin ® DGI
Appearance/remarks	cream, good	pleasant	cream,	cream,	no homogeneous	no homogeneous
	sensorial	sensorial	pleasant	pleasant	cream,	cream,
	properties on	properties,	on the	on the	deposition	deposition of
	the skin	very	skin	skin	of solids	solids
		workable
	experiment number
	Comparative	Comparative	Comparative	Inventive	Comparative
	Example	Example	Example	Example	Example
	Ingredients	68	69	70	71	72
	Aristoflex ® AVC				1.05
	Aristoflex ® HMB
	Noncrosslinked	2	1	1	1.05	1.5
	copolymer as per Ex. 3
	Water	87.1	88.1	88.1	87.6	86.6
	VP/VA Copolymer	3		3		3
	Liquid paraffin	1	1	1	1	1
	Cetiol ® 868	1	1	1	1	1
	Silcare ® 15M50	1.5	1.5	1.5	1.5	1.5
	Tegin ® M	0.3
	Hostaphat ® KL 340 D	0.7
	Phenonip ®	0.4	0.4	0.4	0.4	0.4
	Glycerol	3	3	3	3	3
	Diaformer ® Z 711 N		3		3	3
	Hostacerin ® DGL
	Hostacerin ® DGI		1	1	1	2
	Appearance/remarks	elastic cream	unpleasantly	elastic	very	elastic
			elastic,	cream	pleasant	cream
			stringing, very		cream, very
			thin		good
					sensorial
					properties on
					the skin

Skin Cream (O/W Emulsion)

Examples 73 to 75

General Mode of Preparation for OMw Creams:

O/W cream

Composition

Example 74

	A	Mineral oil, low-viscosity	1.00%
		Cetiol ® 868	1.00%
		SilCare ® 15M50	1.50%
		Hostaphat ® KL 340 D	1.00%
	B	Aristoflex ® AVC	1.05%
		Noncrosslinked copolymer with	0.45%
		Laureth-7 MA as per Example 3
	C	Water	ad 100.00%
		Glycerol	3.00%
		Phenonip ®	0.40%
Preparation
	I	Mixing of A and B
	II	Stirred incorporation of C into I
	III	Homogenizing

Formulations 73 and 75 were prepared in analogy to the general mode of preparation for O/W creams (see Table 7).

TABLE 7
O/W creams
	experiment number
	Comparative	Inventive	Comparative
	Example	Example	Example
Ingredients	73	74	75
Aristoflex ® AVC		1.05
Noncrosslinked	1	0.45	1.5
copolymer as per
Example 3
Water	88.1	87.6	86.6
Liquid paraffin	1	1	1
Cetiol ® 868	1	1	1
Silcare Silicone ® 15M50	1.5	1.5	1.5
Tegin ® M	0.3
Hostaphat ® KL 340 D	0.7
Phenonip ®	0.4	0.4	0.4
Glycerol	3	3	3
Hostacerin ® CGI			2
Appearance/remarks	product	cream, pleasant	runny,
	separates	on the skin,	separates
	overnight	stable	overnight

Antiaging Gels

Examples 76 to 79

General Mode of Preparation for Antiaging Gels:

Antiaging gel

Composition

Example 77

	A	Aristoflex ® HMB	0.30%
		Noncrosslinked copolymer with	0.70%
		Laureth-7 MA as per Example 3
		Water	ad 100%
		NIPA ® BIOPURE 100	0.30%
	B	Glycolic acid, (30% in water)*	3.33%
Preparation
	I	Dissolution of components A
	II	Addition of B to I
	*neutralized with NaOH to pH 4

Formulations 76, 78, and 79 were prepared in analogy to the general mode of preparation for antiaging gels (see Table 8).

TABLE 8
Antiaging gels
	experiment number
	Inventive	Inventive	Inventive	Inventive
	Example	Example	Example	Example
Ingredients	76	77	78	79
Aristoflex ® AVG	0.3		0.3
Aristoflex ® HMB		0.3		0.3
Noncrosslinked	0.7	0.7
copolymer as per
Example 3
Noncrosslinked			0.7	0.7
copolymer as per
Example 5
Water	99.7	99.7	95.4	95.4
NIPA Biopure ® 100	0.3	0.3	0.3	0.3
Glycolic acid, neutralized	3.33	3.33	3.33	3.33
Viscosity in mPas	880	795	190	55
(at 20 rpm)
Appearance/remarks	stable gel	stable gel	fluid	fluid

Chemical identification (INCI nomenclature) of commercial products used:

Abil ® EM-90            Cetyl PEG/PPG-10/1 Dimethicone
Aristoflex ® AVC        Ammonium Acryloyldimethyltaurate/VP
                        Copolymer
Aristoflex ® HMB        Ammonium Acryloyldimethyltaurate/
                        Beheneth-25 Methacrylate Crosspolymer
Carbopol ® 980          Carbomer
Cetiol ® 868            Ethylhexyl Stearate
Cloisonne ® Super Green Mica and Titanium Dioxide and Iron
                        Oxides and Ferric
                        Ferrocyanide
Creasparkles Metallic   Polyethylene Terephthalate and Glycerol and
Silver 700 ® (Glitter)  Acrylamide/Ammonium Acrylate Copolymer
                        and Aluminum Powder
Diaformer ® Z-651 N     Acrylates/Lauryl Acrylate/Stearyl Acrylate/
                        Ethylamine Oxide Methacrylate Copolymer
Diaformer ® Z 711 N     Acrylates/Lauryl Acrylate/Stearyl Acrylate/
                        Ethylamine Oxide Methacrylate Copolymer
Diaformer ® Z 712 N     Acrylates/Lauryl Acrylate/Stearyl Acrylate/
                        Ethylamine Oxide Methacrylate Copolymer
Eusolex ® 232           Phenylbenzimidazole Sulfonic Acid
Genagen ® CAB 818       Cocamidopropyl Betaine
Genapol ® LA 070        Laureth-7
Genapol ® LRO           Sodium Laureth Sulfate
Hostacerin ® DGI        Polyglyceryl-2 Sesquiisostearate
Hostacerin ® DGL        PEG-10 Polyglyceryl-2 Laurate
Hostaphat ® KL 340 D    Trilaureth-4 Phosphate
NIPA Biopure ® 100      Imidazolidinyl Urea
Nipaguard ® MPA         Benzyl Alcohol and Methylparaben and
                        Propylparaben
Phenonip ®              Phenoxyethanol and Methylparaben and
                        Ethylparaben
                        and Butylparaben
                        and Propylparaben
                        and isobutylparaben
Plantacare ® 818 up     Coco-Glucoside
Luviskol ® PVP K 30     PVP (Polyvinylpyrrolidone)
SilCare ® Silicone SEA  Trideceth-9 PG-Amodimethicone and
                        Trideceth-12
SilCare ® 15M50         Phenyltrimethicone
Tegin ® M               Glyceryl Stearate
Tylose ® H 10000 G4     Hydroxyethylcellulose

Claims

1. A cosmetic or pharmaceutical preparation comprising: I) at least one water-soluble non-crosslinked copolymer including A) at least one structural unit of the formula (1)

2. The preparation according to claim 1, wherein Ra, Rb, a, and b in the structural unit of the formula (1) are selected from the group consisting of the following combinations: Ra=Rb=H and a=b=0;Ra=Rb=H, a=0 and b=1;Ra=Rb=H, a=1 and b=0; andRa=H, Rb=CH3, a=1 and b 0.

3. The preparation according to claim 2, wherein Ra, Rb, a, and b in the structural unit of the formula (1) are selected from the group consisting of the following combinations: Ra=Rb=H, a=1 and b=0 andRa=H, Rb=CH3, a=1 and b=0.

4. The preparation according to claim 1, wherein, in the structural unit of the formula (1), R2a is an ethylene or propylene radical,x is a number between 3 and 50, andR2b is a saturated or a mono- or polyunsaturated aliphatic or cycloaliphatic hydrocarbon radical.

5. The preparation according to claim 1, wherein R2b in the structural unit of the formula (1) is a (C6-C22)-hydrocarbon radical.

6. The preparation according to claim 5, wherein the hydrocarbon radical is an alkyl or a mono- or polyunsaturated alkenyl radical.

7. The preparation according to claim 1, wherein R2b in the structural unit of the formula (1) is a radical selected from the group consisting of: stearyl, lauryl, cocoyl, undecyl, behenyl, cetearyl, cetyl, and myristyl.

8. The preparation according to claim 1, wherein, in the structural unit of the formula (2), R3 is H, Z is —C(CH3)2—CH2—, and X is hydrogen, sodium, potassium, ammonium, or a mixture thereof.

9. The preparation according to claim 1, wherein the degree of neutralization of the structural unit of the formula (2) is 70 to 100 mol %.

10. The preparation according to claim 1, wherein the molar fractions of the structural unit of the formula (1) and of the structural unit of the formula (2) in the copolymer of component I) are in each case from 0.1 to 99.9 mol %.

11. The preparation according to claim 1, wherein the fraction of the structural unit of the formula (1) in the copolymer of component I) is from 50.1 to 99.9 mol %.

12. The preparation according to claim 1, wherein the fraction of the structural unit of the formula (1) in the copolymer of component I) is from 0.1 to 50 mol %.

13. The preparation according to claim 1, wherein the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) is selected from the group consisting of: a) a polymer based on methacrylic acid or acrylic acid and modified (meth)acrylic acid,b) a homopolymer of dimethylaminoethyl(meth)acrylates, quaternized with methyl chloride,c) a copolymer of dimethylaminoethyl(meth)acrylate, quaternized with methyl chloride and acrylamide,d) a crosslinked copolymer of vinyl isodecanoate and (meth)acrylic acid,e) a polyvinyl alcohol,f) a polyvinyl methyl ether,g) a polyacrylamide,h) a polyvinylamide,i) a polyvinylpyrrolidone,j) a poly(meth)acrylic acid, a poly(meth)acrylic ester, and other poly(meth)acrylic acid derivatives,k) a polyethylene oxide,l) a copolymer of maleic anhydride and vinyl methyl ether,m) a polysulfonic acid,n) a crosslinked homopolymer of acrylamidoalkylsulfonic acid, a salt thereof, or a mixture thereof,o) copolymers of acrylamidoalkylsulfonic acid, a salt thereof, or a mixture thereof, and comonomers selected from the group consisting of: acrylamide, hydroxyethyl(meth)acrylate and cationically modified (meth)acrylates, andp) a natural and modified natural polymer based on a polysaccharide.

14. The preparation according to claim 1, wherein the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) is selected from the group consisting of: a) a polymer based on methacrylic acid or acrylic acid and modified (meth)acrylic acid,g) a polyacrylamide,j) a poly(meth)acrylic acid, a poly(meth)acrylic ester, and other poly(meth)acrylic acid derivatives,m) a polysulfonic acid,n) a crosslinked homopolymer of acrylamidoalkylsulfonic acid, a salt thereof, or a mixture thereof,o) a copolymer of acrylamidoalkylsulfonic acid, a salt thereof, or a mixture thereof, and comonomer selected from the group consisting of: acrylamide, hydroxyethyl (meth)acrylate and cationically modified (meth)acrylates, andp) a natural and modified natural polymer based on a polysaccharide.

15. The preparation according to claim 1, wherein the weight fraction of crosslinking comonomers, based on the total mass of the polymers of component II), is from 0% to 20% by weight.

16. The preparation according to claim 1, wherein the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) is a copolymeric thickener selected from the group consisting of: a1) 1% to 50% by weight of the structural repeating unit of the formula (3)

17. The preparation according to claim 1, wherein the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) is a crosslinked polymer comprising crosslinking structures derived from methylenebisacrylamide; methylenebismethacrylamide; esters of unsaturated monocarboxylic and polycarboxylic acids with polyols.

18. The preparation according to claim 1, wherein the at least one water-soluble or water-swellable crosslinked or noncrosslinked copolymeric or homopolymeric thickener of component II) is a crosslinked polymer comprising crosslinking structures derived from trimethylolpropane triacrylate.

19. The preparation according to claim 1, wherein the at least one water-soluble non-crosslinked copolymers of component I) the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) or both contain one or more further structural units derived from at least one monomer selected from olefinically unsaturated acids and their salts with monovalent and divalent counterions.

20. The preparation according to claim 1, wherein the weight ratio of the at least one water-swellable non-crosslinked polymer of component I), to the at least one water-soluble or water-swellable polymeric thickener of component II) is in the range from 1 to 99:99 to 1.

21. The preparation according to claim 1, containing the polymer mixture of components I) and II) in an amount of from 0.1% to 10% by weight.

22. The preparation according to claim 1, wherein the cosmetic or pharmaceutical preparation is in the form of a hair treatment, haircare, hairstyling or hair cleaning composition.

23. The preparation according to claim 1, wherein the cosmetic or pharmaceutical preparation is in the form of an aqueous, gel-like cosmetic or pharmaceutical composition.

24. The preparation according to claim 1, wherein the cosmetic or pharmaceutical preparation is in the form of a hair gel.

25. The preparation according to claim 1, wherein the cosmetic or pharmaceutical preparation is in a sprayable form.

26. The preparation according to claim 1, comprising one or more film formers.

27. The preparation according to claim 1, comprising one or more UV filters.

28. The preparation according to claim 1, comprising one or more antioxidants.

29. The preparation according to claim 1, wherein the cosmetic or pharmaceutical preparation is transparent or translucent.

30. The preparation according to claim 1, which is wherein the cosmetic or pharmaceutical preparation is emulsifier-free, oil-free, or both.

31. The preparation according to claim 1, comprising as component II) at least one water-soluble or water-swellable crosslinked copolymeric thickener containing at least one structural units of the formula (1), at least one structural units of the formula (2), and at least one crosslinking structural units derived from monomers having at least two olefinic double bonds.

32. The preparation according to claim 1, wherein R2b in the structural unit of the formula (1) is a (C12-C18)-hydrocarbon radical.

33. The preparation according to claim 5, wherein the hydrocarbon radical is an alkyl radical.

34. The preparation according to claim 1, wherein R2b in the structural unit of the formula (1) is a radical selected from the group consisting of: stearyl, lauryl, cetyl, and myristyl.

35. The preparation according to claim 1, wherein, in the structural unit of the formula (2), R3 is H, Z is —C(CH3)2—CH2—, and X is hydrogen, ammonium, or a mixture thereof.

36. The preparation according to claim 1, wherein the degree of neutralization of the structural unit of the formula (2) is 80 to 100 mol %.

37. The preparation according to claim 1, wherein the degree of neutralization of the structural unit of the formula (2) is 80 to 99 mol %.

38. The preparation according to claim 1, wherein the fraction of the structural unit of the formula (1) in the copolymer of component I) is from 70 to 95 mol %.

39. The preparation according to claim 1, wherein the fraction of the structural unit of the formula (1) in the copolymer of component I) is from 80 to 90 mol %.

40. The preparation according to claim 1, wherein the fraction of the structural unit of the formula (1) in the copolymer of component I) is 5 to 25 mol %.

41. The preparation according to claim 1, wherein the fraction of the structural unit of the formula (1) in the copolymer of component I) is from 6 to 15 mol %.

42. The preparation according to claim 13, wherein the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) is: a) a polymer derived from crosslinked polymers of acrylic acid, copolymers of (meth)acrylic acid and polyalkylene polyether, and hydrophobically modified poly(meth)acrylates.

43. The preparation according to claim 13, wherein the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) is: m) a copolymer based on acrylamidoalkylsulfonic acid, a salt thereof, or a mixture thereof, and one or more comonomers selected from cyclic N-vinylcarboxamides and linear N-vinylcarboxamides, or hydrophobically modified crosslinked acrylamidoalkylsulfonic acid copolymers.

44. The preparation according to claim 13, wherein the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) is: p) a cellulose ether, a cellulose derivative, carboxymethylcellulose, hydroxyethylcellulose, a gelatin, a starch, a starch derviative, a sodium alginate, a xanthan, a guar, a guar derivative, scleroglucan, tragacanth or a dextrin derivative.

45. The preparation according to claim 13, wherein the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) is: p) a dextrin ester.

46. The preparation according to claim 17, wherein the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) is a crosslinked polymer comprising crosslinking structures derived from butanediol and ethylene glycol diacrylate and methacrylate, trimethylolpropane triacrylate (TMPTA) and trimethylolpropane trimethacrylate (TMPTMA); an allyl compound, an-allyl ester of phosphoric acid; and/or a vinylphosphonic acid derivative or a mixture thereof.

47. The preparation according to claim 17, wherein the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener component II) is a crosslinked polymer comprising crosslinking structures originating derived from allyl(meth)acrylate, triallyl cyanurate, diallyl maleate, polyallyl esters, tetraallyloxyethane, triallylamine, tetraallylethylenediamine; and/or trimethylolpropane triacrylate (TMPTA) or a mixture thereof.

48. The preparation according to claim 19, wherein the at least one water-soluble non-crosslinked copolymer of component I) the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) or both contain at least one further structural unit derived from N-vinylformamide (NVF), N-vinylmethylformamide, N-vinylmethylacetamide (VIMA), N-vinylacetamide, N-vinylpyrrolidone (NVP), N-vinylcaprolactam; or amides of acrylic or of methacrylic acid.

49. The preparation according to claim 19, wherein the at least one water-soluble non-crosslinked copolymer of component I) and/or the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) or both contain at least one further structural unit derived from acrylamide, N,N-dimethylacrylamide, N,N-diethylacrylamide, alkoxylated acrylamides and methacrylamides.

50. The preparation according to claim 20, wherein the weight ratio of the non-crosslinked copolymer of component I), to the at least one water-soluble or water-swellable polymeric thickener of component II) is in the range from 1 to 99:99 to 1.

51. The preparation according to claim 20, wherein the weight ratio of the at least one water-swellable non-crosslinked polymer of component I), to the at least one water-soluble or water-swellable polymeric thickener of component II) is in the range from 10 to 90:90 to 10.

52. The preparation according to claim 20, wherein the weight ratio of the at least one water-swellable non-crosslinked polymer of component I), to the at least one water-soluble or water-swellable polymeric thickener of component II) is in the range from 20 to 80:80 to 20.

53. The preparation according to claim 20, wherein the weight ratio of the at least one water-swellable non-crosslinked polymer of component I), to the at least one water-soluble or water-swellable polymeric thickener of component II) is in the range from 30 to 70:70 to 30.

54. The preparation according to claim 1, wherein the cosmetic or pharmaceutical preparation is in the form of a transparent or translucent, colorless hair gel.

55. The preparation according to claim 4, wherein, in the structural unit of the formula (1), R2a is an ethylene radical.

56. The preparation according to claim 4, wherein, in the structural unit of the formula (1), x is a number between 6 and 30.

57. The preparation according to claim 16, wherein R, R1 and R2 are identical or different and are hydrogen or a linear or branched alkyl or alkenyl group having in each case 1 to 20 carbon atoms.

58. The preparation according to claim 16, wherein R, R1 and R2 are identical or different and are hydrogen or a linear or branched alkyl or alkenyl group having in each case 1 to 12 carbon atoms.

59. The preparation according to claim 17, wherein the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener or of component II) is a crosslinked polymer comprising crosslinking structures derived from di-acrylates and tri-acrylates and -methacrylates.

60. The preparation according to claim 19, wherein the at least one or more water-soluble non-crosslinked copolymers of component I) and/or the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) or both contain one or more further structural units derived from styrenesulfonic acid, vinylsulfonic acid, vinylphosphonic acid, allylsulfonic acid, methallylsulfonic acid, acrylic acid, (meth)acrylic acid, maleic acid and maleic anhydride and salts thereof; esters of (meth)acrylic acid with aliphatic, aromatic or cycloaliphatic alcohols having a carbon number from 1 to 22; esters of (meth)acrylic acid with alkyl ethoxylates, open-chain and cyclic N-vinyl amides (N-vinyllactams) having a ring size of 4 to 9 atoms.

61. The preparation according to claim 19, wherein the at least one water-soluble non-crosslinked copolymer of component I) and/or the at least one water-soluble or water-swellable crosslinked or non-crosslinked copolymeric or homopolymeric thickener of component II) or both contain at least one further structural unit derived from MAPTAC and APTAC; 2-vinylpyridine; 4-vinylpyridine; vinyl acetate; glycidyl methacrylate; acrylonitrile; vinyl chloride; vinylidene chloride; tetrafluoroethylene and/or DADMAC.