Claims
- 1. A compound of the formula ##STR32##
- 2. A compound of the formula
- 3. A method for treating malaria comprising the step of administering a compound according to claim 1 to an individual afflicted with malaria.
- 4. The method of claim 3 which further comprises administration of a second antimalarial compound.
- 5. The method of claim 4 wherein the second antimalarial compound is benflumetol.
- 6. A compound of the formula wherein R is selected from the group consisting of alkyl, alkenyl, aryl and heteroaryl.
- 7. The compound of claim 6 wherein R represents a p-fluorophenyl, p-carboxyphenyl, a p-HO.sub.3 S-phenyl, ethyl or a methyl group.
- 8. A method for treating malaria comprising the step of administering a compound of claim 6 to an individual afflicted with malaria.
- 9. The method of claim 8 which further comprises administration of a second antimalarial compound.
- 10. The method of claim 9 wherein the second antimalarial compound is benflumetol.
- 11. A method for treating malaria comprising the step of administering a compound according to claim 7 to an individual afflicted with malaria.
- 12. The method of claim 11 which further comprises administration of a second antimalarial compound.
- 13. The method of claim 12 wherein the second antimalarial compound is benflumetol.
- 14. A method for treating malaria comprising the step of administering a compound according to claim 2 to an individual afflicted with malaria.
- 15. The method of claim 14 which further comprises administration of a second antimalarial compound.
Parent Case Info
This application is a continuation-in-part of U.S. application Ser. No. 08/758,661, filed Dec. 2, 1996, now U.S. Pat. No. 5,932,591.
Government Interests
The invention described and claimed herein was made in part under Grant No. AI 34885 from the National Institutes of Health. The U.S. Government has certain rights in the invention.
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO 9202217 |
Feb 1992 |
WOX |
Non-Patent Literature Citations (2)
Entry |
Posner et al., "Synthesis and antimalarial activities of structurally simplified 1,2,4-trioxanes related to artemisinin," Heteroat. Chem., 6(2), pp. 105-116 (Abstract), 1995. |
Posner et al., "Evidence for the Importance of High Valent Fe=O and of a Diketone in the Molecular Mechanism of Action of Antimalarial Trioxane Analogs of Artemisinin," J.Am.Chem.Soc., vol. 118, pp. 3537-3538, Apr. 10, 1996. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
758661 |
Dec 1996 |
|