This application represents the national stage entry of PCT International Application PCT/EP2016/053118 filed Feb. 15, 2016, which claims benefit of German Application 102015103766.1 filed Mar. 15, 2015, all of which is incorporated herein in its entirety by reference.
The present invention relates to a weighing hood for weighing pharmaceutically active and toxic substances in a laboratory.
The pharmaceutical and chemical industries have created effective medicines and preparations through intensive development work, which remain effective for longer periods of time despite at lower concentrations. As a result, even the smallest amounts of active or toxic substances are potentially dangerous for researchers and laboratory technicians working with them.
The weighing process, in which such substances are handled “in the open,” and proportioned using high-precision scales (precision up to 0.001 mg), involves serious risks, because particles invisible to the naked eye, frequently smaller than 10 μm, are released into the air by such substances, and can thus contaminate laboratory personnel through the air.
Weighing hoods are used in the weighing process to protect laboratory technicians, which have a ventilated and vented chamber that can be accessed from the front by the laboratory technician via a work opening. While sitting or standing, the laboratory technician inserts his forearm into the work chamber, usually resting it on an armrest, and thus handles the laboratory utensils and substances located on the work surface. These utensils include the aforementioned high-precision laboratory scales, as well as containers in which the various substances that are to be portioned are located, and further work devices such as a spatula, for retrieving the substances from the containers and placing them in weighing boats on the laboratory scale. After weighing the substances, they may then be transferred to another container.
The disadvantage with conventional weighing hoods is that external effects such as air turbulence or mechanical vibrations may affect the extremely high-precision scales, and thus have an effect on the weighing results. But even scales operated in the air circulation mode, thus those not connected to the building exhaust air system, instead having an autonomous filter system and their own ventilator, which vacuums off the air from the work chamber, feeding it through the filter system, and then returning the purified air to the laboratory space, frequently have the disadvantage that vibrations from the ventilator can have an effect on the weighing results. The weighing results are thus not necessary consistent and reproducible.
Likewise, the ergonomics of conventional weighing hoods are not always conducive to a very relaxed and substantially non-fatiguing work. Moreover, for reasons of occupational hygiene it is important that weighing hoods can be easily cleaned and decontaminated. This is not always the case with conventional weighing hoods, due to the areas that are often difficult to access because of the construction thereof. Furthermore, changing the filters in weighing hoods operated in the air circulation mode also involves the danger that hazardous substances may be released from the filters, and the laboratory technician may come in contact with them.
One object of the present invention is therefore to eliminate the disadvantages of the prior art, or at least to minimize them, and furthermore, to obtain advantages that cannot be obtained with conventional weighing hoods.
This object is achieved by the combination of features in the independent claim 1. Optional or advantageous features of the invention are given in the dependent Claims.
According to a preferred embodiment of the invention, a weighing hood for weighing pharmaceutically active or toxic substances in a laboratory comprises a housing that defines a work space, wherein a front surface of the housing has a work opening that is always open in an intended use of the weighing hood, a work surface that delimits the floor of the work space, an armrest in the region of the work opening, and a support, which supports the weight of the housing, the work surface, and the armrest, wherein the work surface is decoupled from the housing, the armrest, and the support in terms of impact and vibration in an intended use of the weighing hood.
There is preferably no direct contact between the work surface and (i) the housing, (ii) the armrest, and (iii) the support.
It is more preferable when there is no releasable force-fitting, form-fitting, or substance-bonding connection between the work surface and (i) the housing, (ii) the armrest, and (iii) the support.
According to a further advantageous embodiment of the invention, the work surface lies exclusively on the support such that it is decoupled from impacts and vibrations.
It is more advantageous when at least one resilient element is provided between the support and the work surface, on which the work surface rests.
The resilient element is preferably produced from rubber or an elastic plastic.
More preferably, the support is configured such that it provides a 3-point or 4-point support for the work surface.
According to a preferred embodiment of the invention, the work surface is monolithic, and has a weight in a range of 40 kg to 60 kg.
The housing and the armrest preferably lie exclusively on the support.
Furthermore, the support preferably has at least one brace, and the resilient element is disposed between the brace and the work surface, wherein the brace is disposed such that a work area of the work surface lying on the resilient element is flush with a surface of the support.
It is furthermore preferred that an elastic joint seal is provided along the lateral and rear circumference of the work surface.
The invention shall now be described by way of example based on a preferred embodiment, with reference to the attached Figures. Therein:
For greater understanding of the Figures and their sectional views, as well as the corresponding descriptions of the Figures, a Cartesian coordinate system is included in some of the Figures. As long as it is not otherwise indicated, the x-axis extends along the width, and the y-axis extends along the depth, and the z-axis extends along the height of the weighing hood.
Even though all of the aspects described herein relate to a weighing hood that is operated in the circulating air mode, at least some of these aspects could also be used in a weighing hood that is operated in an exhaust air mode.
When exhaust air is being referred to in the following description, this refers to that air that is discharged from the work space of the weighing hood and then fed into an exhaust air filter system for purifying purposes. With a weighing hood that is operated in the exhaust air mode, i.e. a weighing hood that is connected to a building exhaust air system, air must be discharged from the work space and filtered, before it is allowed to enter the atmosphere in the building.
Thus, the only difference is that with the exemplary embodiment described herein, the discharged and filtered exhaust air is returned thereto with the aid of a ventilator in the laboratory space in which the weighing hood is installed, while with a weighing hood operated in the exhaust air mode, the exhaust air is discharged into the atmosphere through an exhaust air duct installed in the building, in which duct the exhaust air filter is usually installed.
Moreover, it should be noted that some of the aspects described herein can also be used in a closed isolator or containment system. An isolator or containment system is a closed hood, the front surface of which does not have a work opening that is always open, but rather, two openings are provided on its front surface, which are sealed off from the interior within the work space by means of two gloves, normally made of rubber. The laboratory technician reaches, so to speak, with his hands through the openings, consequently sliding the work gloves on. In contrast to such closed isolators or containment systems, the weighing hood described herein is open because it has an opening that is always open.
The weighing hood 1 illustrated in
The support 30, which is preferably designed as a counter framework, comprises four legs 31 in the exemplary embodiment shown here, each of which is provided with a leveling means at the foot end, which is not described in greater detail. This leveling means is advantageous when the floor on which the weighing hood 1 is placed has any irregularities, such that a wobbling of the overall hood 1 can be prevented with the use of one or more leveling means.
The legs 31 are interconnected by cross braces 32 for reasons of stability, which extend along either the width (x-axis) and/or the depth (y-axis). As shall be described in greater detail in reference to
The housing 10, which delimits a work space 19, comprises a double walled 16a, 16b deflector wall 16 at the rear of the work space 19. A hollow chamber 16c (
The front plate 14 is shown in the closed position in
A work opening 11 that is always open in an intended use of the weighing hood 1 is disposed below the pivotable front plate 14. The laboratory technician obtains access to the work space 19 through this work opening 11. Normally, the laboratory technician is seated in front of the weighing hood 1, wherein the seated position is such that the work opening 11 is at the height of the slightly bent forearm of the laboratory technician, such that he can conduct his work in the work space 19 ergonomically. He observes his work through the transparent front plate 14 in this sitting position. In order to enable a good overall visibility of what takes place in the work space 19, the lateral walls 15 as well as the upper part 12 are preferably also transparent. The front plate 14, the upper part 12 and the lateral walls 15 are preferably made of acrylic glass.
In order to provide the laboratory technician with a view of the work devices and utensils located on the work surface 20 with as little reflection as possible, which in turn contributes to a non-fatiguing working with the weighing hood 1, the front plate 14, as can be seen in
To facilitate the opening of the front plate 14, the lower edge of the front plate 14 has a bead, which preferably has a round cross section (y-axis). When the front plate 14 is closed, this bead rests against a bead-like vertical column 17 having the same diameter, disposed on the front edge of the lateral walls 15, which is enlarged in relation to these lateral walls, and which has a convex recess on an upper end surface, in which the bead of the front plate 14 lies. In other words, the convex curvature of the bead at the lower end of the front plate 14 corresponds to the curvature of the concave recess at the upper end of the bead 17 on the lateral wall 15.
An armrest 40 is provided in the region of the work opening 11, which can also be referred to as an inflow profile combined with an armrest function, on which the laboratory technician can rest his forearm while working in order that he can conduct his work with as little fatigue as possible and with a steady hand. The armrest 40 extends over nearly the entire width (x-axis) of the work space 19 thereby. As can be seen in reference to
An air passage, which is difficult to see in
In order to allow the air supply to flow into the work space 19 through the gap between the armrest 40 and the work surface 20 with as little turbulence as possible, the front edge of the work surface 20 is designed in a flow-optimized and convex manner. The armrest 40 is also designed in a flow-optimized manner at its undersurface facing the work surface 20 as well as at its surface facing the work opening 11. As can be seen in
A disposal system integrated in the work surface 20 can likewise be seen in
As is shown in
The lower edge of the lateral wall 15, which, like the upper part 12 and the front plate 14 is preferably made of acrylic glass, is likewise framed in a profile 18 preferably made of metal. This profile 18 lies on the cross brace 32 located below it in the assembled state.
It can likewise be seen in
The work surface 20 preferably has a monolithic structure, and is preferably made of a technological ceramic. The weight of the work surface 20 is preferably (depending on the size) in a range of 40 kg to 60 kg. In order to seal the work space 19, an elastic joint seal is provided between the work surface 20 and the deflector wall 16, as well as between the work surface 20 and the lateral walls 15 on the edges of the two lateral edges, as well as at the back surface.
The room air, or ambient air, which enters through both the air passage between the armrest 40 and the work surface 20 as well as through the work opening 11 in the work space 19, is vacuumed into the hollow space 16c in the deflector wall 16 through the slots (not shown) provided in the wall element 16b with the aid of the ventilator 70. As can be seen in
All of the components of the exhaust air filter system 60, the ventilator 70, the hose 80 and the exhaust outlet 90 are preferably disposed beneath the work surface 20. All of these components of the weighing hood 1 can be attached to the support 30 or on a downward extending extension of the deflector wall 16 (
In referring again to
As can be seen in
At least one light source is integrated in the hinge 13, which preferably comprises at least one LED strip, which preferably extends over at least 75% of the width, or length (x-axis) of the hinge 13.
As can be seen in
Preferably, two LED strips are provided in the recess 13c, their color temperature is mixed, and depending on the requirements can each have a different kelvin number (color temperature).
Preferably, one LED strip has a color temperature of 3000 K, while the other LED strip has a color temperature of 6000 K. By mixing the colors of the two LED strips, various light temperatures can be generated in the work space 19, e.g. warm white (3000 K), neutral white (4500 K) or daylight white (6000 K).
Such defined light temperatures are necessary, for example, for identifying the colors of pharmaceutical substances. The color of the pharmaceutical substance that is to be weighed is preferably compared with a calibrated color card at a defined light temperature, thus determining the color of the pharmaceutical substance.
The light source or the preferably at least one LED strip is encapsulated in a transparent protective tube, preferably made of plastic. On one hand, this provides a chemical protection against aggressive substances that are handled in the work space 19. On the other hand, a cleaning and decontamination of the work space 19 is facilitated thereby, because the danger of a short circuit to the light source supplied with an electrical voltage is prevented.
A preferred rotational brake is contained in the hinge, which is not shown in the Figures. Numerous rotational brakes can also preferably be provided, depending on the weight of the front plate 14. As a result of such rotational brakes, the opened front plate 14 can automatically return, in a braked manner, to the closed position, and does not simply fall down, which could lead to damage, or injury to the operating personnel.
Likewise not shown in the Figures is an angle limiter, which limits the upward opening angle of the front plate 14, and thus defines the maximum open position of the front plate 14. This angle limiter is like a stop, and is preferably set such that the maximum open position of the front plate 14 is that position in which the front plate 14 can remain in a delicate balance. Alternatively, and also preferably, a catch can also be provided (not shown), which locks the front plate 14 in the maximum open position.
While
Because the work surface 20 rests on a resilient element 22 according to this further aspect, and has no direct contact to any of the components of the support 30, the deflector wall 16 or the armrest 32, the work surface 20 is entirely decoupled from impacts and vibrations, such that any contact by the laboratory technician with a component of the weighing hood, e.g. with the armrest 40 and the front plate 14, has no effect on any weighing results. Vibrations potentially caused by the ventilator 70, and continuing over the exhaust air filter system 60 and the deflector wall 16, are thus not transferred to the work surface 20. The work surface 20 is likewise decoupled from any building vibrations. If the laboratory in which the weighing hood 1 is installed is located in a higher floor in which building vibrations are stronger, the work surface 20 can be entirely decoupled from the impacts and vibrations of such building vibrations through the selection of a resilient element having a lower damping constant, e.g. a gas spring. As a matter of course, a gas spring can also be adjusted such that it sufficiently absorbs other types of vibrations.
A perspective illustration of a node profile or corner profile 40 according to a further aspect is shown in
The corner profile 50 has a base section 51, from which a projection 53 extends downward, in the z-direction, the dimensions of which in turn are selected such that it can fit into the leg 31 designed as a hollow profile. Moreover, the corner profile 50 has a slot-shaped recess 54 running in the z-direction, the depth of which (y-axis) is selected such that it is suitable for the form-fitting accommodation and stable retention of the lateral wall 15. A pin-like projection 55 extends in the x-direction away from the upper end section of the corner profile 50, the dimensions and cross section of which are selected such that it can fit into the armrest 40, which is airfoil-shaped and designed as a hollow profile. The flow-optimized airfoil shape of the armrest 40 can be clearly seen in
As is describe above, the surface of the armrest 40 facing the work opening 11 is flow-optimized and has a convex design. It can be seen in
As can be seen in
Such corner profiles 50 in accordance with this aspect simplify not only the construction of the weighing hood 1, but they also offer advantages regarding the necessary regular cleaning and decontamination of the weighing hood 1, because there are no ledges, difficult to access locations, or any open recesses that are difficult to clean. In addition, corner profiles 50 designed in this manner ensure a low-turbulence inflow of the ambient air into the work space 19 in the regions of the corner profiles 50.
A control and/or display panel 42 in accordance with a further aspect can likewise be seen in
The display and/or control panel 42 can preferably only have display elements on which various control functions of the weighing hood 1 are displayed. It can, however, also be a combined panel comprising control and display elements 42, via which various functions of the weighing hood can also be controlled. An acoustic or visual warning signal can also be issued via the panel 42.
The display and control panel 42 preferably comprises five illuminated capacitive touchpads, and one acoustic warning sound emitter. All of the operating states of the weighing hood can be displayed and activated in an ergonomically beneficial manner. The laboratory technician, usually sitting in front of the weighing hood 1, can thus preferably control all of the functions of the weighing hood via the panel 42, and likewise have them displayed there, without having to substantially change his sitting position, let alone stand up.
Because the display and/or control panel 42 comprises capacitive touchpads, an unintentional touching of one of the touchpads with a forearm, which is usually covered by clothing that poorly conducts electricity, and normally lies on the armrest 40, causes no activation of the touchpad, and thus no change to the operating state of the weighing hood 1. The touchpads preferably comprise, e.g., “weighing hood on/off,” “light on/off,” light temperature 3000 k/4500K/6000K,” “alarm,” “change filter.”
A filter 62 is disposed upstream of the tube-shaped support element 61, which is supported in a groove-shaped receiver 68. This groove-shaped receiver 68 is connected in turn to the end section of the tube-shaped support element 61, such that at least the unfiltered air side (and preferably the purified air side) of the filter 62 is tilted. This tilting angle preferably corresponds to the tilting angle of the end surface of the tube-shaped support element 61. Both the tube-shaped support element 61 and the filter 62, as well as the groove-shaped receiver 68 are contained in a housing 65. An opening 69 is provided on the undersurface of the housing 65, which is in a fluid connection with the ventilator 70 (
A waste bag attachment 63 is likewise attached to the housing 65. This waste bag attachment 63 is used when changing filters 62. Otherwise, it is covered by a releasable flap 64.
Because the filter 62 is not vertically (z-axis) oriented, but instead is at an acute angle to the vertical, a releasing of particles on the unfiltered air surface of the filter, through shaking and gravity continuously acting thereon, and their falling through the opening 69, is prevented during the changing process through this tilted alignment, from where these particles could then end up, unobstructed, in the laboratory space.
Another advantage of the exhaust air filter system 60 shown in
The so-called “bag changing technique” is used for changing filters. For this, the cover 64 is removed from the housing 65, and a waste bag (not shown) is connected to a first groove 63a by means of an O-ring. Subsequently, the laboratory technician slides the waste bag attached to the waste bag attachment 63 to the right, toward the filter, subsequently releasing the filter 62 from the tube-shaped support element 61 with the bag in both hands, and moves the filter 62 to the left, until the bag, which was upended, so to speak, during the releasing of the filter 62, is again in its normal orientation. Subsequently, a second bag is likewise attached to the waste bag attachment 63 by means of an O-ring, outside the first bag. A fully contamination-free removal of the first bag from the waste bag attachment 63 is ensured through the use of the second bag. If the filter 62 is replaced in this manner, a new filter 62, including the groove-shaped receiver 68, is attached to the tube-shaped support element 61, and the cover is then reconnected to the housing in an airtight manner.
The filters 62 used here are preferably so-called suspended matter filters, in the category of HEPA filters (“High Efficiency Particulate Airfilter”).
Furthermore, an additional filter may be provided in the discharge outlet 90. In this manner, the safety of the overall system is increased, if the (first) filter 62 shown in
According to a further aspect, a detection device 100 is contained in the deflector wall 16, as can be seen in
The unit comprised of a laser diode and photodetector is active during operation of the weighing hood 1 in order to issue a warning signal, visible or audible, to the laboratory technician who unintentionally, or even intentionally, moves the front plate 14 away from the closed position while the weighing hood 1 is in use. As long as the front plate 14 is closed, and the hinge 13 does not move, the laser beam emitted by the laser diode is detected by the photodetector. If the photodetector fails to receive a laser beam for any reason, it is then concluded that the hinge 13 has rotated, and the front plate 14 must therefore have been moved upward. The photodetector then transmits a signal to a control device, not shown, which in turn causes a warning signal to be issued, in the case of a visible and acoustic warning signal, on the panel 42 in the armrest 40.
The aspects of the weighing hood 1 depicted in
The features described above, of every aspect, can be combined arbitrarily. Even though a combination of individual features may appear to be technically absurd, the person skilled in the art will know which features can be combined with one another in a technically reasonable manner.
Number | Date | Country | Kind |
---|---|---|---|
10 2015 103 766 | Mar 2015 | DE | national |
Filing Document | Filing Date | Country | Kind |
---|---|---|---|
PCT/EP2016/053118 | 2/15/2016 | WO | 00 |
Publishing Document | Publishing Date | Country | Kind |
---|---|---|---|
WO2016/146315 | 9/22/2016 | WO | A |
Number | Name | Date | Kind |
---|---|---|---|
4893686 | Chretien | Jan 1990 | A |
5141066 | Strickler | Aug 1992 | A |
6734398 | Cecchi | May 2004 | B1 |
20080258365 | Van De Sande et al. | Oct 2008 | A1 |
20120125697 | Lauer | May 2012 | A1 |
20130068542 | Izumo | Mar 2013 | A1 |
Number | Date | Country |
---|---|---|
2631924 | Jan 1978 | DE |
10042437 | Mar 2002 | DE |
102011000429 | Aug 2012 | DE |
0917910 | May 1999 | EP |
1312871 | May 2003 | EP |
2230494 | Sep 2010 | EP |
S58206930 | Dec 1983 | JP |
2001025387 | Jan 2001 | JP |
Entry |
---|
PCT International Search Report, PCT/EP2016/053118, dated Apr. 29, 2016, 3 pages. |
PCT Written Opinion, PCT/EP2016/053118, dated Apr. 29, 2016, 7 pages. |
Number | Date | Country | |
---|---|---|---|
20180161835 A1 | Jun 2018 | US |