Wheat growing process utilizing selective herebicide

BACKGROUND OF THE INVENTION
This invention relates to a novel pyrazolesulfonamide derivative, a process for preparing the compound and a herbicide cotaining the compounds as an active component. In order to protect important crops such as rice plants, wheat, cotton and sugar beets from damges by weeds to achieve an increased yield, it is indispensable to use a herbicide. In recent years in particular, a herbicide having selectivity (or discriminativity) is saught after as it can kill only weeds selectively (or discriminatively) without damages to crops by agricultural chemicals even when a foliage treatment is applied simultaneously on crops and weeds in a cultivated land wherein useful crops and weeds are grown together. Also, from viewpoints of the prevention of environmental pollution, the transportion, and the economical cost reduction in application of chemicals, studies and researches have been made over many years on such compounds that may achieve a higher herbicidal activity with use of chemcicals in a lower amount. Some of the compounds having such a property are presently used as the herbicide having selectivity. Still, however, there are further demands for new compounds having such a property.
Conventionally, a number of compounds having sulfonylurea structure has been known. Any of these, however, show very strong activities to sugar beets. For example, sugar beets have extremely high sensibility to chlorsulfuron which is known as a herbicide for wheat, and accordingly the sugar beets which are cultured as second crops of wheat are known to be seriously suffered from damages by agricultural chemicals even after two years, because of a trace amount of the acvtive component remaining in the soil. Also, other sulfonylurea compounds than the chlorsulfuron are also considered to have very particularly strong effect to sugar beets, and, of the sulfonylurea type compounds, the compound which may have the selectivity on sugar beets have been hitherto almost unknown.
As a prior technique, European Patent Publication No. 87,780 discloses a pyrazolesulfonylurea which may have the sturcture similar to the compound of this invention. However, there has been nothing disclosing the compound wherein a heterocyclic ring is substituted on a pyrazole ring as this invention discloses.
SUMMARY OF THE INVENTION
The present inventors have made researches over many years to develop herbicides having the selectivity on important crops, and have examined herbicidal properties of a number of compounds to create compounds having a higher herbicidal effect and the selectivity. As a result, it was found that a pyrazolesulfonamide derivative of Formula (I) shown below (hereinafter often referred to as "the compound of this invention") has a strong herbicidal effect to various weeds while retaining high safety to the important crops in either case of the soil treatment or the foliage treatment.
According to the invention, there is provided a pyrazolesulfonamide derivative represented by Formula (I): ##STR1## wherein Q represents a group of; ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 each independently represent a hydrogen atom, a halogen atom, a nitro group, a C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a group of COOR.sup.10, a group of S(O).sub.n R.sup.11, a group of NR.sup.12 R.sup.13, a C.sub.1 -C.sub.8 alkoxy group, a group of SO.sub.2 NR.sup.8 R.sup.9, a group of SO.sub.2 OR.sup.11 or an unsubstituted phenyl group or a phenyl group substituted with a halogen atom, a nitro group, a group of COOR.sup.10, a C.sub.1 -C.sub.8 alkoxy group or a C.sub.1 -C.sub.8 alkyl group;
R.sup.4 and R.sup.5 each independently represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a nitro group, a group of COOR.sup.10, a group of S(O).sub.n R.sup.11, a C.sub.1 -C.sub.8 alkoxy group or an unsubstituted phenyl group or a phenyl group substituted with a halogen atom, a group of COOR.sup.10, a nitro group, a C.sub.1 -C.sub.8 alkoxy group or a C.sub.1 -C.sub.8 alkyl group;
R.sup.6 and R.sup.7 each independently represent a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group;
R.sup.8 and R.sup.9 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a phenyl group;
R.sup.10 represents a hydrogen atom or a C.sub.1 -C.sub.8 alkyl group;
R.sup.11 represents a C.sub.1 -C.sub.8 alkyl group and n is an integer of 0, 1 or 2;
R.sup.12 and R.sup.13 each independently represent a hydrogen atom or a C.sub.1 -C.sub.8 alkyl group;
m represents an integer of 0, 1 or 2, and R represents a hydrogen atom or a C.sub.1 -C.sub.8 alkyl group;
B and D each independently represent a hydrogen atom, a halogen atom, a nitro group, a C.sub.1 -C.sub.8 alkyl group, an arylalkyl group, a C.sub.1 -C.sub.8 alkoxy group, a halogenated C.sub.1 -C.sub.8 alkyl group, a group of COOR.sup.14, a group of CONR.sup.15 R.sup.16, a group of S(O).sub.n R.sup.17, a cyano group, a group of NR.sup.18 R.sup.19, a group of SO.sub.2 NR.sup.20 R.sup.21, a group of OH, an unsubstituted benzoyl group or a benzoyl group substituted with a halogen atom or a C.sub.1 -C.sub.8 alkyl group, or an unsubstituted phenyl group or a phenyl group substituted with a halogen atom, a nitro group, a group of COOR.sup.10 or a C.sub.1 -C.sub.8 alkyl group;
R.sup.14 represents a hydrogen atom, an unsubstituted C.sub.1 -C.sub.8 alkyl group (or a C.sub.1 -C.sub.8 alkyl group substituted with an unsubstituted C.sub.1 -C.sub.8 alkoxy group or a C.sub.1 -C.sub.8 alkoxy group substituted with a group of R.sup.10 O, a halogenated C.sub.1 -C.sub.8 alkoxy group, a cyano group, a phenoxy group, a c.sub.1 -C.sub.8 alkoxycarbonyl group, a group of R.sup.10 R.sup.11 N, a C.sub.3 -C.sub.7 cycloalkyl group, a C.sub.1 -C.sub.8 alkylthio group or a C.sub.1 -C.sub.8 alkylcarbonyl group), an unsubstituted C.sub.1 -C.sub.8 alkenyl group or a C.sub.1 -C.sub.8 alkenyl group substituted with a halogen atom, an unsubstituted C.sub.1 -C.sub.8 alkynyl group or a C.sub.1 -C.sub.8 alkynyl group substituted with a halogen atom, a halogenated C.sub.1 -C.sub.8 alkyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a benzyl group;
R.sup.15 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a phenyl group, and R.sup.16 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group;
R.sup.17 represents a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a phenyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyloxy group or a C.sub.1 -C.sub.8 alkynyloxy group, and n represents an integer of 0, 1 or 2;
R.sup.18 and R.sup.19 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylcarbonyl group or a C.sub.1 -C.sub.8 alkylsulfonyl group;
R.sup.20 and R.sup.21 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group or a C.sub.1 -C.sub.8 alkynyl group;
R.sup.10 is as defined above;
E represents a hydroge atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, or a C.sub.1 -C.sub.8 alkoxy group;
W represents an oxygen atom, a sulfur atom or a group of N--R.sup.16, wherein R.sup.16 is as defined above;
G represents a group of; ##STR3## wherein X and Y each independently represent a hydrogen atom, a halogen group, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkoxy group, a C.sub.1 -C.sub.8 alkoxyalkyl group, a halogenated C.sub.1 -C.sub.8 alkyl group, or a halogenated C.sub.1 -C.sub.8 alkoxy group, a group of NR.sup.22 R.sup.23, a group of OCH(R.sup.10)COOR.sup.10, a group of COOR.sup.10, a cyclopropyl group, a group of CH(OR.sup.24).sub.2, a C.sub.1 -C.sub.8 alkylthio group or a halogenated C.sub.1 -C.sub.8 alkylthio group;
R.sup.22 and R.sup.23 each independently represent a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group;
R.sup.24 represents a C.sub.1 -C.sub.8 alkyl group;
R.sup.10 is as defined above;
X.sup.1 and Y.sup.1 each independently represent a hydrogen atom, a halogen group, a C.sub.1 -C.sub.8 alkyl group or a C.sub.1 -C.sub.8 alkoxy group;
X.sup.2 represents a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkylthio group or a C.sub.1 -C.sub.8 alkoxy group, and Y.sup.2 represents a C.sub.1 -C.sub.8 alkyl group;
Z represents a nitrogen atom or a group of C--R.sup.25 ;
R.sup.25 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or a halogenated C.sub.1 -C.sub.8 alkyl group, a halogen atom, a C.sub.1 -C.sub.8 alkoxy group or a 5-membered ring containing an oxygen atom together with Y or Y.sup.1 ;
with the proviso that the group: ##STR4## in Formula (I) is not substituted on the nitrogen atom in the pyrazole ring, and, when the group of --(CHR).sub.m --Q is not substituted on the nitrogen atom in the pyrazole ring, the substituent for B or D on the nitrogen atom is selected from a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, a group of CH.sub.2 CN, a C.sub.1 -C.sub.8 alkoxyalkyl group, a C.sub.1 -C.sub.8 alkylthioalkyl group, a group of --CH.sub.2 COOR.sup.10, a group of --COR.sup.10, a group of SO.sub.2 R.sup.24, a group of SO.sub.2 NR.sup.10 R.sup.24 or an unsubstituted phenyl group or a phenyl group substituted with a halogen atom, a nitro group, a group of COOR.sup.10 or a C.sub.1 -C.sub.8 alkyl group; R.sup.10 and R.sup.24 is as defined above.
The above compound can be obtained by a process for preparing a pyrazolesulfonamide derivative represented by Formula (I)': ##STR5## wherein Q, m, R, B, D, E and G are as defined above, and
W' represents an oxygen atom or a sulfur atom;
which comprises allowing a pyrazolesulfonyl(thio)isocyanate derivative represented by Formula (II): ##STR6## wherein Q, m, R, B, D and W' are as defined above; with the proviso that the group --SO.sub.2 N.dbd.C.dbd.W' in Formula (II) is not substituted on the nitrogen atom in the pyrazole ring, and, when the group of --(CHR).sub.m --Q is not substituted on the nitrogen atom in the pyrazole ring, the substituent for B or D on the nitrogen atom is selected from a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, a group of CH.sub.2 CN, a C.sub.1 -C.sub.8 alkoxyalkyl group, a C.sub.1 -C.sub.8 alkylthioalkyl group, a group of --CH.sub.2 COOR.sup.10, a group of --COR.sup.10, a group of SO.sub.2 R.sup.24, a group of SO.sub.2 NR.sup.10 R.sup.24 or an unsubstituted phenyl group or a phenyl group substituted with a halogen atom, a nitro group, a group of COOR.sup.10 or a C.sub.1 -C.sub.8 alkyl group;
R.sup.10 and R.sup.24 is as defined above;
to react with an aminopyrimidine, aminotriazine or aminotriazole derivative represented by Formula (III): ##STR7## wherein G and E are as defined above; in an inert solvent, or allowing a pyrazolesulfonyl(thio)carbamate derivative represented by Formula (IV): ##STR8## wherein Q, m, R, B, D and W' are as defined above; with the proviso that the group --SO.sub.2 N.dbd.C.dbd.W' in Formula (II) is not substituted on the nitrogen atom in the pyrazole ring, and, when the group of --(CHR).sub.m --Q is not substituted in the nitrogen atom in the pyrazole ring, the substituent for B or D on the nitrogen atom is selected from a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, a group of CH.sub.2 CN, a C.sub.1 -C.sub.8 alkoxyalkyl group, a C.sub.1 -C.sub.8 alkylthioalkyl group, a group of --CH.sub.2 COOR.sup.10, a group of --COR.sup.10, a group of SO.sub.2 R.sup.24, a group of SO.sub.2 NR.sup.10 R.sup.24 or an unsubstituted phenyl group or a phenyl group substituted with a halogen atom, a nitro group, a group of COOR.sup.10 or a C.sub.1 -C.sub.8 alkyl group;
R.sup.10 and R.sup.24 is as defined above;
to react with an aminopyrimidine, aminotriazine or aminotriazole derivative represented by Formula (III): ##STR9## wherein G and E are as defined above; in an inert solvent.
Certain compounds of the above compounds show very high selectivity on beets. Also, certain compounds of the compound of this invention have the selectivity not only to beets but also to wheat, cotton. corn, etc. The certain compounds of the compound of this invention, having the selectivity on wheat, are suited for selectivity controlling wild oats. Wild oats are known to be improtant weeds growing with the culture of wheat. However, since wheat and wild oats belong to a plant species which is akin to each other, the known sulfonylurea type herbicides (the above-mentioned chlorosulfuron, for example) having the selectivity on wheat have also no effect to the wild oats, and thus it has been difficult to control them. The compound of this invention, on the other hand, shows a high herbicidal activity in a very low amount of the active component as compared with the conventional herbicides, and accordingly it is useful also as a herbicide for orchards and uncultivated lands.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
The compound of this invention, represented by Formula (I) can be readily prepared by selecting either one of the procedures shown by the following reaction schemes. ##STR10## wherein B, D, Q, m, R, E, W' and G are as defined above.
Namely, a pyarazolesulfonyl(thio)isocyanate derivative (II) is dissolved in an inert solvent of sufficiently dried dioxane, acetonitrile, etc., to which a pyrimidine, triazine or triazole derivative shown by Formula (III) is added to carry out stirring, whereupon a compound of Formula (I)' which is a part of the compound of this invention is obtained by generally swift reaction. When the reaction proceeds with difficulty, a suitable base or bases such as triethylamine, triethylenediamine, pyridine, sodium alkoxide and sodium hydride may be added to allow the reaction to proceed readily. ##STR11## wherein B, D, Q, m, R, E, W', G and R.sup.26 are as defined above.
Namely, a pyrazolesulfonamide derivative (V) is reacted with chloro(thio)formate or (thio)carbonate in a solvent such as acetone, methyl ethyl ketone and acetonitrile and in the presence of a base or bases such as potassium carbonate to form a compound (IV), followed by heating together with a compound (III) to obtain a compound (I)' which is a part of the compound of this invention. ##STR12## wherein B, D, Q, m, R, E, W', G and R.sup.16 are as defined above.
Namely, the above sulfonylguanidine type compound which is a part of the compound of this invention can be synthesized in accordance with the process disclosed in Japanese Unexamined Patent Publications No. 167570/1984, No. 6654/1985 and No. 36467/1985.
The starting pyrazolesulfonyl(thio)isocyanate (II) or pyrazolesulfonyl(thio)carbamate derivative (IV) used in the reactions in Reaction Scheme 1 and Raction Scheme 2 can be synthesized by first synthesizing a pyrazolesulfonamide (V) by selecting a suitable process as mentioned below, and further making reference to the process disclosed in European Patent Publication No. 87,780 and Japanese Unexamined Patent Publication No. 13266/1980.
This pyrazolesulfonamide which is an intermediate used in this invention is also a novel compound, and may be obtained by selecting a suitable process from the processes shown in Reaction Schemes 4 to 9 below. ##STR13##
In the above;
(a): NaNO.sub.2.HCl or NaNO.sub.2.HBr
(b): SO.sub.2.Cu salt
(c): NH.sub.4 OH or ammonium carbonate
(d): Cu salt
(e): POCl.sub.3 or POBr.sub.3
(f): P.sub.2 S.sub.5
(g): NaSH
(h): NaOH.NH.sub.4 OH.NaOCl
(i): NaSCH.sub.2 Ph
(j): Cl.sub.2 /CH.sub.3 COOH.H.sub.2 O
(k): BuLi or LiN(i-Pr).sub.2, followed by Cl.sub.2 or Br.sub.2
(l): an oxidant
(m): (1) ClSO.sub.3 H, (2) SOCl.sub.2 or PCl.sub.5
(n): (1) BuLi or LiN(i-Pr).sub.2, (2) SO.sub.2, (3) N-chlorosuccinimide
(o): ClC(.dbd.S)NMe.sub.2 /base
(p): heating
(q): R.sup.27 Hal/base
In the above formulae, B, D, Q, m, R, E, W and G are as defined above; and R.sup.27 is C.sub.1 -C.sub.8 alkyl group, a C.sub.1 -C.sub.8 alkenyl group, a C.sub.1 -C.sub.8 alkynyl group, a group of CH.sub.2 CN, a C.sub.1 -C.sub.8 alkoxyalkyl group, a C.sub.1 -C.sub.8 alkylthioalkyl group, a group of CH.sub.2 COOR.sup.10, a group of COR.sup.24, a group of SO.sub.2 R.sup.24 or a group of SO.sub.2 NR.sup.10 R.sup.24 ; R.sup.10 and R.sup.24 are as defined above.
Usually, pyrazolesulfonamide (V) is obtained by reacting a corresponding pyrazolesulfonylchloride with ammonia water or ammonium carbonate. In order to introduce a sulfonyl group into pyrazole, the following methods may be used:
(i) An amino group is subjected to diazonium decomposition in the presence of sulfur dioxide to obtain pyrazolesulfonylchloride.
(ii) Hydroxypyrazole is formed into o-pyrazolethiocarbamate, and thereafter a sulfur atom is introduced into pyrazole ring by a rearrangement reaction, followed further by oxidation to obtain pyrazolesulfonylchloride.
(iii) A sulfur atom is introduced into pyrazole by a nucleophilic substitution with a halogen atom, etc., followed further by oxidation, if necessary, to obtain pyrazolesulfonylchloride.
(iv) Carbanion of pyrazole is formed by use of a base, on which sulfur dioxide is acted, followed by halogenation to obtain pyrazolesulfonylchloride.
(v) Pyrazolesulfonylchloride is directly obtained by sulfuryl chloride.
(vi) A pyrazole derivative obtained by any of the above methods is modified with other functional group by utilizing an attribute of pyrazole.
More specifically;
(i) Taking the procedures of Reaction Scheme 4, aminopyrazole is formed into a diazonium salt with use of sodium nitrite, etc. in hydrochloric acid or hydrobromic acid, and then sulfur dioxide is acted on it in the presence of a catalyst such as copper salt usually used for the diazonium decomposition, to obtain the corresponding pyrazolesulfonylchloride. By allowing ammonia water to act on it, the desired pyrazolesulfonamide (V) can be obtained.
(ii) Taking the procedures of Reaction Scheme 8, hydroxypyrazole is used as a starting material to obtain o-pyrazolethiocarbamate, which is then heated for its transition to s-pyrazolethiolcarbamate, followed by oxidation with use of chlorine in a solvent such as acetic acid to obtain pyrazolesulfonylchloride. Similar to Reaction Scheme 3, the desired pyrazolesulfonamide can be obtained by allowing ammonia water to act on the pyrazolesulfonylchloride.
Both of these Reaction Schemes 4 and 8 are not affected by the position of substituent.
(iii) A nucleophilic substitution against pyrazole usually takes place most readily at the 5-position, and, in the next place, at 3-position it may sometimes takes place when an electron attractive group is substituted on the 4-position. Taking the procedures of Reaction Scheme 5 by utilizing this tendency, a sulfur atom is introduced into the 5-position by treating halogenated pyrazole with use of sodium hydrosulfide, sodium salt of benzylmercaptan, etc., followed by oxidation with use of chlorine in a solvent such as acetic acid to obtain pyrazolesulfonlchloride. Similar to Reaction Scheme 4, the desired pyrazolesulfonamide (V) can be obtained by allowing ammonia water to act on it. It is also possible to obtain the desired pyrazolesulfonamide (V) by forming an intermediate 5-mercaptopyrazole into sulfenamide, followed by oxidation thereof. The starting 5-position halogenated pyrazole can be obtained by diazo decomposition of aminopyrazole, a reaction of hydroxypyrazole with phosphorous oxychloride or phosphorous oxybromide, or by formation of a 5-position anion with use of a strong base such as butyl lithium and lithium diisopropylamide, followed by halogenation.
(iv) When a substituent is at the 1-position, the hydrogen at the 5-position of a pyrazole ring generally has relatively strong acidity. Taking the procedures of Reaction Scheme 7, an anion can be formed with use of a strong base such as butyl lithium and lithium diisopropylamide, thereafter treating it with sulfur dioxide and N-halogenosuccinimide to form pyrazolesulfonylchloride, and then treating it with ammonia water to obtain the desired pyrazolesulfonamide (V).
(v) As compared with the nucleophilic substitution, an electrophilic substitution against a pyrazole ring tends to take palce at the 4-position. Taking the procedures of Reaction Scheme 6, pyrazole-4-sulfonylchloride can be directly obtained with use of chlorosulfonic acid.
(vi) Taking the procedures of Reaction Scheme 9, alkylation, acylation or sulfonylation of pyrazolesulfonamide having no substituent at the 1-position results in alkylation, acylation or sulfonylation at the 1-position or the 2-position. According to this procedures, it is somethimes possible to obtain two kinds of compounds as a mixture wherein the substituents at the 3-position and the 5-position have been replaced with each other, but it is possible to separate these compounds by column chromatography, recrystallization, etc. for use as an intermediate for the compound of this invention.
It is also possible by utilizing an attribute of pyrazole to obtain various types of pyrazolesulfonamide (V) by newly intorducing a substituent into pyrazolesulfonamide, or by modifying a substituent having been introduced in it.
Pyrazoles used as starting materials in the above reactions can be synthesized in most cases by making reference to A. N. Kost and I. I. Groundberg, Advan. Heterocyclic Chem., Vol. 6, p. 347, 1966; T. L. Yacobs, Heterocyclic Compounds, R. C. Elderfield, Vol. 5, p. 45, Wiley, New York, 1957; or K. Shofield, M. R. Grimmett and B. R. T. Keene, Heterocyclic Nitrogen Compounds The Azoles, Cambridge University Press, London, Newyork, Melbourne, 1976; Kevin T. Potts, Comprehensive Heterocyclic Chemistry, Vol. 5, p. 167, Pergamon Press, 1984. When the group of (CHR).sub.m --Q is substituted on the 1-position of a pyrazole ring, it can be obtained by using (CHR).sub.m --QNHNH.sub.2 in place of hydrazine, methylhydrazine, phenylhydrazine, etc. in the above publications.
Usually, it is possible for one skilled in the art to obtain an intermediate of the compound of this invention by studying experimental conditions on the basis of the descriptions hereinabove and the known arts in the above publications. In the following, synthesis examples for synthesizing the compound of this invention and the intermediate pyrazolesulfonamide will be described concretely as Exampels and Reference Examples, by which, however, by no means the invention is limited.
REFERENCE EXAMPLE 1
Synthesis of 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide
(1) Synthesis of ethyl 5-chloro-1-(2-pyridyl)pyrazole-4-carboxylate:
14 g of ethyl 5-amino-1-(2-pyridyl)pyrazole-4-carboxylate was dissolved in 50 ml of conc. hydrochloric acid, and the solution obtained was cooled to -5.degree. C., to which 5.5 g of sodium nitrite dissolved in 10 ml of water was added cropwise, and thereafter, stirred for 10 minutes, followed by addition of 0.6 g of urea. The solution thus obtained was added dropwise at 5.degree. C. to a solution obtained by adding 2 g of sulfur dioxide and 0.6 g of cuprous chloride to 50 ml of 1,2-dichloroethane. After stirring at room temperature for 1 hour, 200 ml of ice water was added thereto, followed by extraction with chloroform. Seperation of the layer of chloroform, washing with water, drying and concentration were then carried out to obtain 13.1 g of the title compound. m.p.: 38.degree. to 42.degree. C.
(2) Synthesis of ethyl 5-mercapto-1-(2-pyridyl)pyrazole-4-carboxylate:
12 g of ethyl 5-chloro-1-(2-pyridyl)pyrazole-4-carboxylate was dissolved in 60 ml of dimethylformamide, to which 9.5 g of 70% sodium hydrosulfide was added and then heated at 90.degree. to 100.degree. C. for 5 hours. After the reaction was completed, ice water was added to make the reaction mixture acidic with use of conc. hydrochloric acid, followed by extraction with chloroform. Separation of the layer of chloroform, washing with water, drying and concentration were then carried out to obtain 11.4 g of the title compound. m.p.: 73.degree. to 76.degree. C.
(3) Synthesis of 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide:
5.8 g of ethyl 5-mercapto-1-(2-pyridyl)pyrazole-4-carboxylate was dissolved in 50 ml of 80% acetic acid, into which chlorine was brown at 5.degree. to 15.degree. C. until it is saturated. After the reaction was completed, 200 ml of ice water was added, followed by extraction with 1,2-dichloroethane. Separation of the layer of 1,2-dichloroethane, washing with water, drying and concentration were then carried out to obtain 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonylchloride. The sulfonylchloride obtained was dissolved in 50 ml of 1,2-dichloroethan, followed by addition of 4 g of ammonium carbonate (containing 30% of ammonia) and stirring at room temperature for 3 hours. After filtration of inorganic salt, solvent was evaporated to obtain 5.7 g of the title compound. The amount obtained after purification by use of a silica gel column chromatography was 3.9 g. m.p.: 134.degree. to 135.degree. C.
REFERENCE EXAMPLE 2
Synthesis of 4-ethoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Example 1. m.p.: 166.degree. to 167.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-3-methyl-1-(2-pyridyl)pyrazole-4-carboxylate, obtained by heating 2-hydrazinopyridine and ethyl .beta.-ethyl-.alpha.-cyanochlotonate in n-butyl alcohol. m.p.: 80.degree. to 81.degree. C.
Ethyl 5-chloro-3-methyl-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 49.degree. to 52.degree. C.
Ethyl 5-mercapto-3-methyl-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 99.degree. to 101.degree. C.
REFERENCE EXAMPLE 3
Synthesis of 4-methoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 and 2. m.p.: 151.degree. to 153.degree. C.
Each of the intermediates had the following property.
Methyl 5-chloro-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 86.degree. to 88.degree. C.
Methyl 5-mercapto-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 120.degree. to 121.degree. C.
REFERENCE EXAMPLE 4
Synthesis of 1-(3,5-dichloropyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 and 2. m.p.: 161.degree. C.
Each of the intermediates had the following property.
Ethyl 5-chloro-1-(3,5-dichloropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 81.degree. to 82.degree. C.
REFERENCE EXAMPLE 5
Synthesis of 4-ethoxycarbonyl-1-(3-methylpyridin-2-yl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 and 2. m.p.: 165.degree. to 170.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(3-methylpyridin-2-yl)pyrazole-4-carboxylate, an oily substance.
Ethyl 5-chloro-1-(3-methylpyridin-2-yl)pyrazole-4-carboxylate, an oily substance.
Ethyl 5-mercapto-1-(3-methylpyridin-2-yl)pyrazole-4-carboxylate, an oily substance.
REFERENCE EXAMPLE 6
Synthesis of 4-ethoxycarbonyl-1-(2-pyrimidyl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 and 2. m.p.: 175.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(2-pyrimidyl)pyrazole-4-carboxylate, m.p.: 190.degree. to 191.degree. C.
Ethyl 5-chloro-1-(2-pyrimidyl)pyrazole-4-carboxylate, m.p.: 80.degree. to 84.degree. C.
Ethyl 5-mercapto-1-(2-pyrimidyl)pyrazole-4-carboxylate, m.p.: 131.degree. to 133.degree. C.
REFERENCE EXAMPLE 7
Synthesis of 3,5-dimethyl-1-(2-pyridyl)pyrazole-4-sulfonamide
(1) Synthesis of 3,5-dimethyl-1-(2-pyridyl)pyrazole:
10 g of acetylacetone was added to 20 ml of ethanol, to which 10.9 g of 2-hydrazinopyridine was further added little by little under ice cooling. After stirring overnight at room temperature, distillation was carried out under reduced pressure. b.p.: 85.degree. to 90.degree. C./0.8 mmHg. Amount obtained: 14.5 g.
(2) Synthesis of 3,5-dimethyl-1-(2-pyridyl)pyrazole-4-sulfonamide:
10.4 g of 3,5-dimethyl-1-(2-pyridyl)pyrazole dissolved in 12.5 ml of chloroform under ice-cooling was added dropwise to a mixed solution of 18 ml of chlorosulfonic acid and 18 ml of chloroform. The mixture was stirred at room temperature for 1 hour and then heated under reflux for 4.5 hours. Next, after chloroform was evaporated under reduced pressure, 25.1 g of phosphorous pentachloride was added little by little, followed by heating at 90.degree. to 100.degree. C. for 1 hour while elevating the temperature gradually. After cooling, ice water was added to the reaction mixture, which was then extracted with benzene. After benzene was evaporated under reduced pressure, 18 g of 28% ammonia water was added dropwise thereto. After stirring overnight at room temperature, solvent was evaporated under reduced pressure to obtain 12.6 g of the title compound as crystals. m.p.: 160.degree. to 163.degree. C.
REFERENCE EXAMPLE 8
Synthesis of 4-bromo-1-(2-pyridyl)pyrazole-3 -sulfonamide
(1) Synthesis of 2-(3-amino-2-pyrazolin-1-yl)pyridine:
The compound was synthesized from 2-hydrazinopyridine and acrylonitrile following the procedures disclosed in U.S. Pat. No. 4,347,251. m.p.: 169.degree. to 171.degree. C.
(2) Synthesis of 3-amino-1-(2-pyridyl)pyrazole:
10 g of 2-(3-amino-2-pyrazolin-1-yl)pyridine was added to a 500 ml acetone suspensison of 50 g of active manganese dioxide ground into powder. After stirring at room temperature for 2 hours, insolubles were filtered off and acetone was evaporated under reduced pressure to obtain 6.4 g of the deisred product as crystals. m.p.: 98.degree. to 101.degree. C.
(3) Synthesis of 3-amino-4-bromo-1-(2-pyridyl)pyrazole:
5.6 g of 3-amino-1-(2-pyridyl)pyrazole was added to 35 ml of acetic acid, to which 5.8 g of bromine was further added dropwise at room temperature. After stirring at room temperature for 20 minutes, crystals precipitated were collected by filtration and dissolved in 50 ml of diluted hydrochloric acid. To this hydrochloric acid solution, added was an aqueous solution of 30% potassium hydroxide for neutralization to obtain 5.3 g of the title compound as crystals. m.p.: 145.degree. to 146.degree. C.
(4) Synthesis of 4-bromo-1-(2-pyridyl)pyrazole-3-sulfonamide:
3 g of 3-amino-4-bromo-1-(2-pyridyl)pyrazole was suspended in 60 ml of hydrochloric acid, to which 2.5 ml of an aqueous solution containing 1.2 g of sodium nitrite was added dropwise at -10.degree. to -5.degree. C. to prepare a solution of diazonium salt. This solution of diazonium salt was added dropwise at 5.degree. C. to 30 ml of acetic acid saturated with sulfur dioxide containing 0.5 g of cuprous chloride. After stirring at room temperature for 20 minutes, 100 ml of water and 300 ml of 1,2-dichloroethane were added and stirred to separate an organic layer. To the organic layer, added was 10 ml of 28% ammonia water, followed by vigorous stirring at room temperature for 1 hour. Thereafter, solvent was evaporated under reduced pressure and 200 ml of ethyl acetate was added. After further stirring, insolubles were filtered off and ethyl acetate was evaporated to obtain 2.2 g of the title compound as a crude product. This crude product was purified by a silica gel column chromatography (developed with ethyl acetate) to obtain 0.5 g of the title compound as a pure product. m.p.: 201.degree. to 203.degree. C.
REFERENCE EXAMPLE 9
Synthesis of 1-methyl-4-(2-pyridyl)pyrazole-5-sulfonamide
(1) Synthesis of .alpha.-ethoxymethylene-2-pyridineacetonitrile:
A mixture of 25 g of 2-pyridineacetonitrile, 63 g of ethyl orthoformate and 11 g of acetate anhydride was stirred at 120.degree. to 130.degree. C. for 3 hours, and thereafter 30 g of ethyl orthoformate and 11 g of acetic anhydride were further added, followed by stirring at 120.degree. to 130.degree. C. for 2 hours while evaporating the low boiling compound. After cooling, distillation was carried out under reduced pressure to obtain 22.7 g of distillates having b.p. of 100.degree. to 130.degree. C./0.1 mmHg (principal distillates: 110.degree. C./0.1 mmHg). To the distillates obtained, added was diisopropyl ether, and then insoluble solids were filtered off and the filtrate was concentrated to obtain 20.7 g of the title compound.
(2) Synthesis of 5-amino-1-methyl-4-(2-pyridyl)pyrazole:
10 g of .alpha.-ethoxymethylene-2-pyridineacetonitrile was dissolved in 100 ml of ethanol, to which 3.1 g of methylhydrazine was added at room temperature. After heating under reflux for 4 hours, concentration under reduced pressure was carried out to obtain 10 g of the title compound. m.p.: 113.degree. to 114.degree. C.
(3) Synthesis of 1-methyl-4-(2-pyridyl)pyrazole:
10 g of 5-aminio-1-methyl-4-(2-pyridyl)pyrazole was dissolved in a solution of 10 ml of conc. sulfuric acid, 30 ml of phosphorous acid and 50 ml of water, to which 15 ml of an aqueous solution containing 5.1 g of sodium nitrite was added dropwise at -10.degree. to -5.degree. C. to prepare a soution of diazonium salt. This solution of diazonium salt was added to 100 ml of 50% hypophosphorous acid containing 0.5 g of cupric oxide, followed by stirring at room temperature, and further stirring at 40.degree. C. for 1 hour. After the reacton was completed, the reaction mixture was made alkaline under ice-cooling with use of 28% ammonia water, followed by extraction with chloroform by adding an excess amount of water. After the liquid extracted with chloroform was dried with use of anhydrous sodium sulfate, solvent was evaporated under reduced pressure to obtain an oily product. The oily product was purified by a silica gel column chromatograpghy to obtain 5.9 g of the title compound as an oily product.
(4) Synthesis of 1-methyl-4-(2-pyridyl)pyrazole-5-sulfonamide:
A 200 ml solution of anhydrous diethyl ether containing 5.9 g of 1-methyl-4-(2-pyridyl)pyrazole was cooled to -70.degree. C., to which was added dropwise a lithium diisopropylamide solution separately prepared (prepared by use of 3.9 g of diisopropylamine and a hexane solution of 15% n-butyllithium). After stirring of the mixture at the same temperature for 1 hour, sulfur dioxide gas was blown into it, followed by further stirring for 1 hour. Filtration was carried out at the stage a cooler was removed and the temperature of the reaction mixture was returned to room temperature, to obtain 10 g of solid lithium sulfinate. 10 g of the lithium sulfinate obtained was added at 5.degree. to 10.degree. C. to 6 g of a suspension comprising 100 ml of water, 100 ml of methylene chloride and 6 g of N-chlorosuccinimide. After vigorous stirring at 5.degree. C. for 20 minutes, 100 ml of 28% ammonia water was added dropwise thereto, followed by further stirring at room temperature for 1 hour. After separation of organic layer, aqueous layer was extracted with dichloromethane and the extract was combined with the organic layer, followed by drying with use of anhydrous sodium sulfate, and then solvent was evaporated under reduced pressure. Crystals precipitated from 3.4 g of an oily crude product were collected by filtration and washed with methanol to obtain 0.9 g of the title compound. m.p.: 195.degree. to 197.degree. C.
Reference Example 9-2
Synthesis of 1-methyl-4-(2-pyridyl)pyrazole-5-sulfonamide: (another procedures)
The above can be also obtained by the process of Reference Example 1. Each of the intermediates had the following property.
5-Chloro-1-methyl-4-(2-pyridyl)pyrazole, m.p.: 81.degree. to 82.degree. C.
5-Mercapto-1-methyl-4-(2-pyridyl)pyrazole, m.p.: 223.degree. to 228.degree. C.
REFERENCE EXAMPLE 10
Synthesis of 4-ethoxycarbonyl-1-(3-pyridazinyl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 189.degree. to 191.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(3-pyridazinyl)pyrazole-4-carboxylate, m.p.: 136.degree. to 137.degree. C.
Ethyl 5-chloro-1-(3-pyridazinyl)pyrazole-4-carboxylate, m.p.: 100.degree. to 107.degree. C.
Ethyl 5-mercapto-1-(3-pyridazinyl)pyrazole-4-carboxylate, m.p.: 155.degree. to 159.degree. C.
REFERENCE EXAMPLE 11
Synthesis of 4-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-5-sulfonamide
Synthesis was carried out following Examples 1 to 6. m.p.: 196.degree. to 198.degree. C.
REFERENCE EXAMPLE 12
Synthesis of 1-(3-chloropyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 178.degree. to 179.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(3-chloropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 65.degree. to 66.degree. C.
Ethyl 5-chloro-1-(3-chloropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 114.degree. to 115.degree. C.
Ethyl 1-(3-chloropyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 62.degree. to 65.degree. C.
REFERENCE EXAMPLE 13
Synthesis of 1-(5-chloropyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide
Synthesis was carried out following the above Reference Example. m.p.: 114.degree. to 115.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(5-chloropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 132.degree. to 133.degree. C.
Ethyl 5-chloro-1-(5-chloropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 109.degree. to 114.degree. C.
Ethyl 1-(5-chloropyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 138.degree. to 139.degree. C.
REFERENCE EXAMPLE 14
Synthesis of 1-(6-chloropyridin-2-yl)-4-methoxycarbonylpyrazole-5-sulfonamide
Synthesis was carried out following the above Reference Example. m.p.: 143.degree. to 145.degree. C.
Each of the intermediates had the following property. Methyl 5-amino-1-(6-chloropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 140.degree. C.
Methyl 1-(6-chloropyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 118.degree. to 120.degree. C.
REFERENCE EXAMPLE 15
Synthesis of 1-(6-chloropyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide
1 g of sulfonamide obtained in Reference Example 14 and 0.3 g of sodium hydroxide were refluxed with stirring for 1 hour in a mixed solvent of ethanol and water. After solvent was evaporated, water was added, followed by neutralization with use of hydrochloric acid. Crystals precipitated were collected by filtration and washed with water to obtain 0.8 g of 1-(6-chloropyridin-2-yl)-4-carboxypyrazole-5-sulfonamide. m.p.: 179.degree. to 182.degree. C.
Next, the above sulfonamide was introduced in ethanol saturated with hydrogen chloride, and, while stirring, heated under reflux for 7 hours. After solvent was evaporated, water was added, followed by extraction with chloroform. Extract liquid was evaporated to dryness to obtain 0.62 g of the title compound. m.p.: 125.degree. to 128.degree. C.
REFERENCE EXAMPLE 16
Synthesis of 4-ethoxycarbonyl-1-(4-methylpyridyn-2-yl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 135.degree. to 137.degree. C.
The intermediate had the following property.
Ethyl 5-amino-1-(4-methylpyridyn-2-yl)pyrazole-4-carboxylate, m.p.: 99.degree. to 100.degree. C.
REFERENCE EXAMPLE 17
Synthesis of 4-ethoxycarbonyl-1-(6-methylpyridyn-2-yl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 131.degree. to 133.degree. C.
REFERENCE EXAMPLE 18
Synthesis of 4-methoxycarbonyl-1-(pyrimidin-2-yl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 263.degree. to 265.degree. C.
Each of the intermediates had the following property.
Methyl 5-amino-1-(pyrimidin-2yl)pyrazole-4-carboxylate, m.p.: 176.degree. to 179.degree. C.
Methyl 5-chloro-1-(pyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 153.degree. to 156.degree. C.
Methyl 5-mercapto-1-(pyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 185.degree. to 186.degree. C.
REFERENCE EXAMPLE 19
Synthesis of 4-n-propyloxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide
Sulfonamide obtained in Reference Example 1 was hydrolyzed following the procedures in Reference Example 15 to obtain 4-carboxy-1-(2-pyridyl)pyrazole-5-sulfonamide (m.p.: 270.degree. to 271.degree. C.), followed by esterification with use of n-propyl alcohol to obtain the title compound. m.p.: 153.degree. to 154.degree. C.
REFERENCE EXAMPLE 20
Synthesis of 4-i-propyloxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Example 19 except that the reaction was carried out for 72 hours for the esterification using i-propyl alcohol. m.p.: 123.degree. to 124.degree. C.
REFERENCE EXAMPLE 21
Synthesis of 1-(6-chloropyridin-2-yl)-4-methoxycarbonyl-3-methylpyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6, 14 and 15. m.p.: 119.degree. to 120.degree. C.
Each of the intermediates had the following property.
Methyl 5-amino-1-(6-chloropyridin-2-yl)-3-methylpyrazole-4-carboxylate, m.p.: 185.degree. to 187.degree. C.
Methyl 1-(6-chloropyridin-2-yl)-5-mercapto-3-methylpyrazole-4-carboxylate, m.p.: 142.degree. to 144.degree. C.
REFERENCE EXAMPLE 22
Synthesis of 4-ethoxycarbonyl-1-(3-fluoropyridin-2-yl)pyrazole-5-sulfonamide
Synthesis was carried out following Examples 1 to 6. m.p.: 177.degree. to 178.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(3-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 136.degree. to 138.degree. C.
Ethyl 5-chloro-1-(3-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 73.degree. to 76.degree. C.
Ethyl 5-mercapto-1-(3-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 71.degree. to 74.degree. C.
REFERENCE EXAMPLE 23
Synthesis of 4-ethoxycarbonyl-1-(pyrazin-2-yl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 189.degree. to 191.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(pyrazin-2-yl)pyrazole-4-carboxylate, m.p.: 138.degree. to 140.degree. C.
Ethyl 5-chloro-1-(pyrazin-2-yl)pyrazole-4-carboxylate, m.p.: 107.degree. to 114.degree. C.
Ethyl 5-mercapto-1-(pyrazin-2-yl)pyrazole-4-carboxylate,m.p.: 130.degree. to 137.degree. C.
4-Ethoxycarbonyl-1-(pyrazin-2-yl)pyrazole-5-sulfonylchloride, m.p.: 105.degree. to 106.degree. C.
REFERENCE EXAMPLE 24
Synthesis of 4-methoxycarbonyl-1-(4-methylpyrimidin-2-yl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 165.degree. to 168.degree. C.
Each of the intermediate had the following property.
Methyl 5-amino-1-(4-methylpyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 163.degree. to 165.degree. C.
Methyl 5-chloro-1-(4-methylpyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 85.degree. to 87.degree. C.
Methyl 5-mercapto-1-(4-methylpyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 127.degree. to 130.degree. C.
REFERENCE EXAMPLE 25
Synthesis of 5-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-4-sulfonamide
(1) Synthesis of 3-methyl-1-(2-pyridyl)pyrazole:
54.7 g of acetylacetoaldehyde dimethylacetal (purity: 90%) was dissolved in 350 ml of ethanol, to which was added dropwise at room temperature 40.7 g of 2-hydrazinopyridine dissolved in 200 ml of ethanol. After stirring at room temperature for 2 hours, the reaction mixture was heated under reflux, and 40 ml of conc. hydrochloric acid was added thereto after cooling. After stirring at 60.degree. C. for 30 minutes, the reaction mixture was concentrated, followed by addition of ice water, was made alkaline with use of ammonia water, and thereafter extracted with chloroform. After drying of organiclayer, solvent was evaporated under reduced pressure to obtain 59.2 g of an oily product. The oily product obtained was distilled under reduced pressure to obtain 52.9 g of the title compound as an oily product. b.p.: 115.degree. to 120.degree. C./10 mmHg.
(2) Synthesis of N-t-butyl-[3-methyl-1-(2-pyridyl)]pyrazole-4-sulfonamide:
To 30 ml of chlorosulfonic acid contained in 60 ml of chloroform, 30 g of 3-methyl-1-(2-pyridyl)pyrazole was added dropwise under ice-cooling, followed by stirring at 60.degree. C. for 3 hours. To a residue obtained by evaporating chloroform under reduced pressure, 30 ml of thionyl chloride was added dropwise at about 60.degree. C. over a period of 1 hour. After the addition, the reaction mixture was stirred at 95.degree. C. for 30 minutes while heating under reflux. After cooling, it was poured into ice water and extracted with chloroform, organic layer was washed with water and dried, and thereafter solvent was evaporated under reduced pressure to obtain 49 g of crude 3-methyl-1-(2-pyridyl)pyrazole-4-sulfonylchloride as an oily product. The sulfonylchloride obtained was dissolved in 50 ml of tetrahydrofuran, and then was added dropwise at 0.degree. to 10.degree. C. to 41.4 g of t-butylamine contained in 100 ml of tetrahydrofuran. After stirring at room temperature for 1.5 hour, filtration was carried out, and filtrate obtained was concentrated to give a residue, to which ethyl acetate was added, followed by washing with diluted hydrochloric acid and drying, and then solvent was evaporated to give crystals. Crystals obtained was washed with ether to obtain 48.6 g of the title compound. m.p.: 174.degree. to 175.degree. C.
(3) Synthesis of N-t-butyl-[5-carboxy-3-methyl-1-(2-pyridyl)]pyrazole-4-sulfonamide:
15 g of N-t-butyl-[3-methyl-1-(2-pyridyl)]pyrazole-4-sulfonamide was dissolved in 300 ml of tetrahydrofuran, to which a lithium diisopropylamine solution (obtained by adding dropwise 75 ml of a 15% n-butyllithium-hexane solution to 11.3 g of diisopropylamine contained in 50 ml of tetrahydrofuran, at -60.degree. to -50.degree. C.) was added dropwise at -70.degree. to -65.degree. C. over a period of 20 minutes. After stirring at the same temperature for 1 hour, carbonic acid gas was blown into the reaction mixture for 30 minutes and further for 30 minutes while the temperature thereof was returned to room temperature. The reaction mixture thus treated was poured into ice water to make it acidic with use of conc. hydrochloric acid, and then extracted with ethyl acetate. Organic layer was dried, and solvent was evaporated under reduced pressure to give crystals, which were then washed with ether to obtain 11.8 g of the title compound. m.p.: 170.degree. to 172.degree. C.
(4) Synthesis of 5-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-4-sulfonamide:
11 g of N-t-butyl-[5-carboxy-3-methyl-1-(2-pyridyl)]pyrazole-4-sulfonamide was added to 50 ml of trifluoroacetic acid, and the mixture was stirred at room temperature for 6 hours, followed by concentration under reduced pressure to obtain crude 5-carboxy-3-methyl-1-(2-pyridyl)pyrazole-4-sulfonamide. Subsequently, 250 ml of methanol were added to the residue, which was then saturated with hydrogen chloride and heated under reflux for 20 hours with stirring. The reaction mixture was concentrated under reduced pressure, followed by addition of ice water, and extracted with ethyl acetate. Organic layer was washed with water and, after drying, solvent was evaporated under reduced pressure to give crystals, which were then washed with ether to obtain the title compound as crystals. m.p.: 175.degree. to 177.degree. C.
REFERENCE EXAMPLE 26
Synthesis of 1-(3-chloro-6-methoxypyridin-2-yl)-4-methoxycarbonylpyrazole-5-sulfonamide
Following the above Reference Examples 1 to 6, methyl 5-mercapto-1-(6-methoxypyridin-2yl)pyrazole-4-carboxylate was synthesized from methyl 5-amino-1-(6-methoxypyridin-2-yl)pyrazole-4-carboxylate (m.p.: 131.degree. to 132.degree. C.), and then derived to sulfonamide. The sulfonamide formed was a 1:1 mixture (white solids) of 1-(3-chloro-6-methoxypyridin-2-yl)-4-methoxycarbonylpyrazole-5-sulfonamide and 4-methoxycarbonyl-1-(6-methoxypyridin-2-yl)pyrazole-5-sulfonamide.
Subsequently, following the procedures in Example 1, the sulfonamide was reacted with methyl chloroformate, and the product was formed by toluene recrystallization to give N-[4-methoxycarbonyl-1-(3-chloro-6-methoxypyridin-2-yl)pyrazole-5-sulfonyl]methylcarbamate. m.p.: 131.degree. to 132.degree. C.
REFERENCE EXAMPLE 27
Synthesis of 4-methoxycarbonyl-1-(3-trifluoromethylpyridin-2-yl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 194.degree. to 195.degree. C.
Each of the intermediates had the following property.
Methyl 5-amino-1-(3-trifluoromethylpyridin-2-yl)pyrazole-4-carboxylate, m.p.: 107.degree. to 110.degree. C.
Methyl 5-chloro-1-(3-trifluoromethylpyridin-2-yl)pyrazole-4-carboxylate, m.p.: 72.degree. to 73.degree. C.
Methyl 5-mercapto-1-(3-trifluoromethylpyridin-2-yl)pyrazole-4-carboxylate, m.p.: 88.degree. to 91.degree. C.
REFERENCE EXAMPLE 28
Synthesis of 4-methoxycarbonyl-1-(6-methylpyridin-2-yl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Example 15. m.p.: 125.degree. to 129.degree. C.
The intermediate had the following property.
1-(6-methylpyridin-2-yl)-4-carboxypyrazole-5-sulfonamide, m.p.: 201.degree. to 202.degree. C.
REFERENCE EXAMPLE 29
Synthesis of 4-ethoxycarbonyl-1-(6-methylpyridin-2-yl)-3-methylpyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 162.degree. to 163.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-3-methyl-1-(6-methylpyridin-2-yl)pyrazole-4-carboxylate, m.p.: 108.degree. to 109.degree. C.
Ethyl 5-chloro-3-methyl-1-(6-methylpyridin-2-yl)pyrazole-4-carboxylate, an oily product.
Ethyl 3-methyl-1-(6-methylpyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 100.degree. to 101.degree. C.
REFERENCE EXAMPLE 30
Synthesis of 4-methoxycarbonyl-1-(6-methylpyridin-2-yl)-3-methylpyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 15 and 19. m.p.: 155.degree. to 159.degree. C.
The intermediate had the following property.
3-Methyl-1-(6-methylpyridin-2-yl)-4-carboxypyrazole-5-sulfonamide, m.p.: 196.degree. to 198.degree. C.
REFERENCE EXAMPLE 31
Synthesis of 4-ethoxycarbonyl-1-(6-ethylpyridin-2-yl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 87.degree. to 88.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(6-ethylpyridin-2-yl)pyrazole-4-carboxylate, m.p.: 116.degree. to 117.degree. C.
Ethyl 5-chloro-1-(6-ethylpyridin-2-yl)pyrazole-4-carboxylate, an oily product.
Ethyl 1-(6-ethylpyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 79.degree. to 80.degree. C.
REFERENCE EXAMPLE 32
Synthesis of 4-ethoxycarbonyl-1-(6-fluoropyridin-2-yl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Example 22. m.p.: 114.degree. to 116.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(6-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 86.degree. to 88.degree. C.
Ethyl 5-chloro-1-(6-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 57.degree. to 60.degree. C.
Ethyl 1-(6-fluoropyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 105.degree. to 107.degree. C.
REFERENCE EXAMPLE 33
Synthesis of 1-(6-bromopyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 142.degree. to 144.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(6-bromopyridin-2-yl)pyrazole-4-carboxylate, m.p.: 135.degree. to 137.degree. C.
Ethyl 1-(6-bromopyridin-2-yl)-5-chloropyrazole-4-carboxylate, m.p.: 91.degree. to 94.degree. C.
Synthesis of ethyl 5-benzylthio-1-(6-bromopyridin-2-yl)pyrazole-4-carboxylate
In 30 ml of dimethylformamide was dissolved 8 g of the above ethyl 1-(6-bromopyridin-2-yl)-5-chloropyrazole-4-carboxylate, to which added were 3 g of benzylmercaptan and 3.5 g of anhydrous potassium carbonate, followed by stirring overnight at room temperature. After the reaction, water was added to the reaction mixture, which was extracted with benzene, followed by washing with water and drying, and then solvent was evaporated to obtain the above carboxylate. This compound was further reacted following the procedures in Reference Example 1 to obtain 4 g of the title sulfonamide.
REFERENCE EXAMPLE 34
Synthesis of 4-ethoxycarbonyl-1-(4-pyrimidyl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 238.degree. to 239.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(4-pyrimidyl)pyrazole-4-carboxylate, m.p.: 135.degree. to 136.degree. C.
Ethyl 5-chloro-1-(4-pyrimidyl)pyrazole-4-carboxylate, m.p.: 139.degree. to 142.degree. C.
Ethyl 5-mercapto-1-(4-pyrimidyl)pyrazole-4-carboxylate, m.p.: 143.degree. to 147.degree. C.
REFERENCE EXAMPLE 35
Synthesis of 4-cyano-1-(4-pyridyl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 211.degree. to 213.degree. C.
Each of the intermediates had the following property.
5-Amino-4-cyano-1-(2-pyridyl)pyrazole, obtained by heating 2-hydrazinopyridine and ethoxymethylenemalononitrile in n-butyl alcohol, m.p.: 197.degree. to 200.degree. C.
5-Chloro-4-cyano-1-(2-pyridyl)pyrazole, m.p.: 130.degree. to 133.degree. C.
4-Cyano-5-mercapto-1-(2-pyridyl)pyrazole, m.p.: 206.degree. to 210.degree. C.
5-Benzylthio-4-cyano-1-(2-pyridyl)pyrazole, obtained by reacting 5-chloro-4-cyano-1-(2-pyridyl)pyrazole with benzylmercaptan and sodium ethylate at room temperature in dimethylformamide. m.p.: 110.degree. to 115.degree. C.
REFERENCE EXAMPLE 36
Synthesis of 4-ethoxycarbonyl-1-(4-pyridyl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 288.degree. to 289.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(4-pyridyl)pyrazole-4-carboxylate, m.p.: 140.degree. to 141.degree. C.
Ethyl 5-chloro-1-(4-pyridyl)pyrazole-4-carboxylate, taken out by extraction with chloroform, after the reaction and after nutralized with use of potassium carbonate.
Ethyl 5-mercapto-1-(4-pyridyl)pyrazole-4-carboxylate, m.p.: 195.degree. to 198.degree. C.
Subsequently, 5.3 g of ethyl 5-mercapto-1-(4-pyridyl)pyrazole-4-carboxylate was suspended in 150 ml of water, and chlorine was passed to the suspension for 15 minutes under ice-cooling. Thereafter, 50 ml of tetrahydrofuran and 30 ml of ammonia water was added thereto, followed by stirring at room temperature for 30 minutes. The reaction mixture was concentrated to collect by filtration white solids formed, which were then washed with water and dried to obtain 3.0 g of the title compound.
REFERENCE EXAMPLE 37
Synthesis of 1-(6-dimethylaminopyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide
The sulfonamide obtained in Reference Example 32 was dissolved in dimethylformamide, to which were added dimethylamine and anhydrous potassium carbonate, followed by stirring overnight at room temperature to obtain the title compound. m.p.: 157.degree. to 160.degree. C.
REFERENCE EXAMPLE 38
Synthesis of 4-methoxycarbonyl-1-(5-methylpyridin-2-yl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 145.degree. to 147.degree. C.
Each of the intermediates had the following property.
5-Amino-4-methoxycarbonyl-1-(5-methylpyridin-2-yl)pyrazole, m.p.: 136.degree. to 138.degree. C.
5-Chloro-4-methoxycarbonyl-1-(5-methylpyridin-2-yl)pyrazole, m.p.: 101.degree. to 102.degree. C.
5-Mercapto-4-methoxycarbonyl-1-(5-methylpyridin-2-yl)pyrazole, m.p.: 144.degree. to 147.degree. C.
REFERENCE EXAMPLE 39
Synthesis of 1-(6-fluoropyridin-2-yl)-4-methoxycarbonylpyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6 and Reference Example 22. m.p.: 174.degree. to 175.degree. C.
Each of the intermediates had the following property.
Methyl 5-amino-1-(6-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 143.degree. to 145.degree. C.
Methyl 5-chloro-1-(6-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 112.degree. to 115.degree. C.
Methyl 1-(6-fluoropyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 120.degree. to 122.degree. C.
REFERENCE EXAMPLE 40
Synthesis of 1,3-dimethyl-5-(2-pyridyl)pyrazole-4-sulfonamide
m.p.: 188.degree. to 190.degree. C.
(1) Synthesis of 1,3-dimethyl-5-(2-pyridyl)pyrazole:
5.9 g of picolinoylacetone was added to 20 ml of ethanol, to which 1.7 g of methylhydrazine was added dropwise little by little under ice-cooling. After stirring overnight at room temperature, the reaction mixture was heated under reflux for 5 hours, followed by concentration to obtain 6.1 g of an oily product.
(2) Synthesis of 1,3-dimethyl-5-(2-pyridyl)pyrazole-4-sulfonamide:
To a mixed solution of 4.2 g of chlorosulfonic acid and 10 ml of chloroform, 5.7 g of 1,3-dimethyl-5-(2-pyridyl)pyrazole dissolved in 5 ml of chloroform was added dropwise under ice-cooling. After stirring at room temperature for 1 hour, the reaction mixture was heated under reflux for 3 hours. Subsequently, chloroform was evaporated under reduced pressure, followed by addition of 30 ml of thionyl chloride and heating under reflux for 6 hours. After the thionyl chloride was evaporated under reduced pressure, 50 ml of tetrahydrofuran was added to the reaction mixture, to which 20 ml of 28% ammonia water was further added dropwise under ice-cooling. After stirring at room temperature for 3 hours, solvent was evaporated, followed by washing with water to obtain 3.5 g of crude product, which was washed with hot benzene to obtain 2.9 g of the title compound. m.p.: 188.degree. to 190.degree. C.
REFERENCE EXAMPLE 41
Synthesis of 4-ethoxycarbonyl- 1-(5-nitropyridin-2-yl)pyrazole-3-sulfonamide
m.p.: 245.degree. to 247.degree. C.
Synthesis of the intermediate was carried out in the following manner.
3-benzylthio-4-ethoxycarbonyl-1-(5-nitropyridin-2-yl)pyrazole:
To 50 ml of dimethylformamide, 2.0 g of 5(3)-benzylthio-4-ethoxycarbonylpyrazole, 1.33 g of 2-chloro-5-nitropyridine and 1.5 g of anhydrous potassium carbonate were added, followed by heating at room temperature for 1 hour and further at a temperature of 60.degree. to 70.degree. C. for 1 hour. After cooling, water was added to the reaction mixture, which was then extracted with chloroform. The layer of chloroform was separated, and after washing with water and drying, solvent was evaporated to obtain 2.5 g of the title compound. m.p.: 164.5.degree. to 165.5.degree. C.
Subsequently, the derivation of the desired product may be carried out following the procedures in Reference Examples 1 to 6.
REFERENCE EXAMPLE 42
Synthesis of 4-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-5-sulfonamide: (procedures other than Reference Example 11)
Properties of intermediates:
Methyl 5-amino-3-methyl-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 115.degree. to 116.degree. C.
Methyl 5-chloro-3-methyl-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 111.degree. to 112.degree. C.
Methyl 3-methyl-5-mercapto-1-(2-pyridyl)pyrazole-4-carboxylate, m.p.: 102.degree. to 105.degree. C.
Synthesis of 4-methoxycarbonyl-3-methyl-1-(2-pyridyl)pyrazole-5-sulfonamide
In 200 ml of methylene chloride, 20.4 g of methyl 3-methyl-5-mercapto-1-(2-pyridyl)pyrazole-4-carboxylate was dissolved, and thereafter 200 ml of water was added. While maintaining the mixture at not higher than 5.degree. C., 64 ml of conc. hydrochloric acid was added thereto, to which 250 ml of an aqueous solution of sodium hypochlorite (effective chlorine concentration: 6%) was added dropwise at -5.degree. C., followed by stirring at -5.degree. C. for 10 minutes. After separation of organic layer, extraction was carried out by adding 100 ml of methylene chloride to the aqueous layer. Organic layer was combined with the previous organic layer, followed by washing with an aqueous solution of sodium bisulfite, and then 40 ml of 28% ammonia water was added at 10.degree. C. or lower. After stirring at room temperature for 10 minutes, solvent was evaporated. Crystals precipitated were filtered, washed with water, further washed with ether and dried to obtain 18.3 g of the title compound. m.p.: 196.degree. to 198.degree. C.
REFERENCE EXAMPLE 43
Synthesis of 1-(6-fluoropyridin-2-yl)-4-methoxycarbonylpyrazole-5-sulfonamide
Synthesis was carried out following Reference Examples 1 to 6. m.p.: 174.degree. to 175.degree. C.
Each of the intermediates had the following property.
Methyl 5-amino-1-(6-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 143.degree. to 145.degree. C.
Methyl 5-chloro-1-(6-fluoropyridin-2-yl)pyrazole-4-carboxylate, m.p.: 112.degree. to 115.degree. C.
Methyl 1-(6-fluoropyridin-2-yl)-5-mercaptopyrazole-4-carboxylate, m.p.: 120.degree. to 122.degree. C.
REFERENCE EXAMPLE 44
Synthesis of 1-(6-dimethylsulfamoylpyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide
(1) Synthesis of 2-chloro-6-dimethylsulfamoylpyridine:
To 50 ml of dimethylformamide were added 10 g of 2,6-dichloropyridine, 8.4 g of benzylmercaptan and 10 g of potassium carbonate, which was then stirred at room temperature for 1 hour, followed by heating to 60.degree. to 70.degree. C. After cooling, water was added to the reaction mixture to carry out extraction with chloroform. Extract was subjected to evaporation under reduced pressure, and thereafter, crystals obtained were dissolved in 200 ml of an aqueous solution of 90% acetic acid. Chlorine gas was blown into the reaction mixture over a period of 10 minutes under ice-cooling. Thereafter, water was added to the reaction mixture, which was then extracted with about 150 ml of chloroform. After the extraction was completed, washing with water was carried out several times, and then 12 g of an aqueous solution of 50% dimethylamine was added dropwise with stirring at about 10.degree. C. After stirring for 1 hour, the layer of chloroform was evaporated under reduced pressure to obtain 12.4 g of 2-chloro-6-dimethylsulfamoylpyridine. m.p.: 53.degree. to 55.degree. C.
(2) Synthesis of 6-dimethylsulfamoyl-2-hydrazinopyridine:
To 12 g of 2-chloro-6-dimethylsulfamoylpyridine were added 30 ml of n-butanol and 4 g of hydrazine hydrate. The mixture was stirred at room temperature for 30 minutes, followed by heating under reflux for 18 hours. After cooling, crystals obtained were filtered and washed with water to obtain 6.1 g of 6-dimethylsulfamoyl-2-hydrazinopyridine. m.p.: 117.degree. to 120.degree. C.
(3) Ethyl 5-amino-1-(6-dimethylsulfamoylpyridin-2-yl)pyrazole-4-carboxylate was synthesized following Reference Example 2. m.p.: 197.degree. to 198.degree. C.
(4) Ethyl 5-chloro-1-(6-dimethylsulfamoylpyridin-2-yl)pyrazole-4-carboxylate was synthesized following Reference Example 1. m.p.: 117.degree. to 120.degree. C.
(5) Ethyl 5-benzylthio-1-(6-dimethylsulfamoylpyridin-2-yl)pyrazole-4-carboxylate:
To 50 ml of dried dimethylformamide, added were 4.2 g of ethyl 5-chloro-1-(6-dimethylsulfamoylpyridin-2-yl)pyrazole-4-carboxylate and 1.46 g of benzylmercaptan and 3.2 g of potassium carbonate, followed by stirring at room temperature for 24 hours in the atmosphere of N.sub.2. After the reaction, inorganic salt was filtered off and dimethylformamide was evaporated from the filtrate to obtain 4.4 g of the title compound as an oily product.
(6) 1-(6-dimethylsulfamoylpyridin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonamide was synthesized following Reference Example 1. m.p.: 102.degree. to 104.degree. C.
REFERENCE EXAMPLE 45
Synthesis of 4-allylcarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide
To a mixture of 2.2 of 4-carboxy-1-(2-pyridyl)pyrazole-5-sulfonamide and 20 ml of allyl alcohol, 1 ml of methanesulfonic acid was added, followed by stirring at 110.degree. C. for 18 hours. The reaction mixture was concentrated under reduced pressure, and purified by silica gel chromatography to obtain 0.7 g of the title compound. m.p.: 140.degree. to 142.degree. C.
REFERENCE EXAMPLE 46
4-Propargyloxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Example 45. m.p.: 106.degree. to 108.degree. C.
REFERENCE EXAMPLE 47
4-(2-chloroethyl)oxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide
Synthesis was carried out following Reference Example 45. m.p.: 119.degree. to 121.degree. C.
REFERENCE EXAMPLE 48
Synthesis of 1-(4,6-dimethylpyrimidin-2-yl)-4-ethoxycarbonylpyrazole-5-sulfonmamide
Synthesis was carried out following Reference Examples 1 to 6 and Reference Example 35. m.p.: 164.degree. to 165.degree. C.
Each of the intermediates had the following property.
Ethyl 5-amino-1-(4,6-dimethylpyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 184.degree. to 186.degree. C.
Ethyl 5-chloro-1-(4,6-dimethylpyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 88.degree. to 89.degree. C.
Ethyl 5-benzylmercapto-1-(4,6-dimethylpyrimidin-2-yl)pyrazole-4-carboxylate, m.p.: 84.degree. to 85.degree. C.

EXAMPLE 1
Synthesis of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide (Compound No. 49)
2.0 g of 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide, 0.82 g of methyl chloroformate and 1.4 g of anhydrous potassium carbonate were heated under reflux in 50 ml of anhydrous acetonitrile for 4 hours. After the reaction was completed, solvent was evaporated under reduced pressure. After dilution with ice water, insolubles were filtered off, and the filtrate was precipitated with use of diluted hydrochloric acid. Crystals precipitated were filtered, washed with water and dried to obtain 2.2 g of N-[4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonyl]methylcarbamate. m.p.: 127.degree. to 129.degree. C.
0.95 g of N-[4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonyl]methylcarbamate and 0.41 g of 2-amino-4,6-dimethoxypyrimidine were heated under reflux in 30 ml of toluene for 6 hours while allowing the toluene to evaporate little by little. Toluene having been decreased was occasionally supplemented. After the reaction was completed, toluene was evaporated under reduced pressure. Isopropyl ether was added to the residue, which was then stirred to obtain 1.1 g of the title compound as crystals. m.p.: 140.degree. to 142.degree. C.
EXAMPLE 2
Synthesis of N-[(4-methoxy-6-methyltriazin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide (Compound No. 51)
To a 70 ml acetone mixture of 8.5 g of 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide and 6.0 g of anhydrous potassium carbonate, added was 3.3 g of n-butylisocyanate at room temperature, followed by heating under reflux for 3 hours. After the reaction was completed, acetone was evaporated under reduced pressure, and then the residue was emptied into ice water to filter insolbles off, and then the filtrate was precipitated with hydrochloric acid. Crystals precipitated was filtered, washed with water and dried to obtain 10.8 g of N-(n-butylcarbamoyl)-4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonamide. m.p.: 180.degree. to 181.degree. C.
Subsequently, the above compound was added to 100 ml of dried toluene, into which 7.5 g of phosgene was blown while heating under reflux, and thereafter the reaction mixture was further heated under reflux for 1.5 hours. After the reaction was completed, solvent was evaporated under reduced pressure to obtain 8.4 g of crude 4-ethoxycarbonyl-1-(2-pyridyl)pyrazole-5-sulfonylisocyanate. 1.3 g of this crude suflonylisocyanate was added to a 30 ml solution of dried acetonitrile, containing 0.42 g of 2-amino-4-methoxy-6-methyltriazine, followed by stirring at room temperature. After the reaction mixture was concentrated, ether was added thereto, followed by stirring at room temperature, and crystals formed were filtered, washed with ether and dried to obtain 1.2 g of the title compound. m.p.: 133.degree. to 136.degree. C.
EXAMPLE 3
Synthesis of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonyl-1-[(2-pyridyl)methyl]pyrazole-3-sulfonamide (Compound No. 6218)
0.7 g of N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-4-ethoxycarbonylpyrazole-5(3)-sulfonamide was dissolved in 10 ml of tetrahydrofuran, to which 0.6 g of potassium t-butylate and 0.29 g of 2-chloromethylpyridine hydrochloride were added, and the mixture was refluxed for 5 hours. Tetrahydrofuran was evaporated under reduced pressure, and then 20 ml of ice water was added and insolbles were filtered off. To the aqueous layer obtained, added was 35% hydrochloric acid to make it acidic, followed by addition of chloroform to carry out extraction. Organic layer was washed with water and dried, and then solvent was evaporated to obtain 0.3 g of an oily product. This oily product was dissolved in a small amount of acetonitrile, to which a small amount of diisopropylether was added, whereupon the title compound in a pure form was crystalized, and was collected by filtration. Amount obtained was 0.18 g. m.p.: 95.degree. to 96.degree. C.
In the following, examples of specific compounds included in the compound of this invention are shown in Table 1 to Table 14 in addition to the compounds synthesized in the above Examples 1 to 3, by which, however, this invention is not limited.
The compounds shown in Table 1 to Table 14 can be synthesized following the procedures in Examples 1 and 2. Properties of some of these compounds are shown in Table 15. In Table 15, the compound number correspond to the compound number in Table 1 to Table 14.
TABLE 1__________________________________________________________________________ ##STR14##No. A B D X Y Z__________________________________________________________________________1 Q.sub.1 H COOMe Me Me CH2 Q.sub.1 H COOMe Me OMe CH3 Q.sub.1 H COOMe OMe OMe CH4 Q.sub.1 H COOMe Me Me N5 Q.sub.1 H COOMe Me OMe N6 Q.sub.1 H COOMe OMe OMe N7 Q.sub.1 H COOMe Me Cl CH8 Q.sub.1 H COOMe Me OEt CH9 Q.sub.1 H COOMe Me H CH10 Q.sub.1 H COOMe Me CH.sub.2 OMe CH11 Q.sub.1 H COOMe Me CF.sub.3 CH12 Q.sub.1 H COOMe Me OCH.sub.2 CF.sub.3 CH13 Q.sub.1 H COOMe Me OCH.sub.2 COOMe CH14 Q.sub.1 H COOMe Cl Cl CH15 Q.sub.1 H COOMe Br Br CH16 Q.sub.1 H COOMe Me Cl N17 Q.sub.1 H COOMe Cl NMe.sub.2 N18 Q.sub.1 H COOMe OMe NMe.sub.2 N19 Q.sub.1 H COOMe Me OEt N20 Q.sub.1 H COOMe Me NHEt N21 Q.sub.1 H COOMe Me CH.sub.2 OMe N22 Q.sub.1 H COOMe Me OCH(Me)COOH N23 Q.sub.1 H COOMe Me COOMe CH24 Q.sub.1 H COOMe Me COOEt CH25 Q.sub.1 H COOMe OMe COOMe CH26 Q.sub.1 H COOMe Cl COOMe CH27 Q.sub.1 H COOMe Me ##STR15## CH28 Q.sub.1 H COOMe Me OCHF.sub.2 CH29 Q.sub.1 H COOMe OCHF.sub.2 OCHF.sub.2 CH30 Q.sub.1 H COOMe Cl OCHF.sub.2 CH31 Q.sub.1 H COOMe Cl OMe CH32 Q.sub.1 H COOMe Cl NH.sub.2 CH33 Q.sub.1 H COOMe Me Me CMe34 Q.sub.1 H COOMe Me Me CCl35 Q.sub.1 H COOMe Me OMe CCl36 Q.sub.1 H COOMe OMe OMe CF37 Q.sub.1 H COOMe Me Me COMe38 Q.sub.1 H COOMe OMe OMe CCF.sub.339 Q.sub.1 H COOMe Me N(Me)OMe CH40 Q.sub.1 H COOMe Me SMe CH41 Q.sub.1 H COOMe Me CH(OMe).sub.2 CH42 Q.sub.1 H COOMe OMe CH(OEt).sub.2 N43 Q.sub.1 H COOMe OMe ##STR16## N44 Q.sub.1 H COOMe Me SCHF.sub.2 CH45 Q.sub.1 H COOMe Me SCHF.sub.2 N46 Q.sub.1 H COOMe Me OCF.sub.2 CF.sub.2 H CH47 Q.sub.1 H COOEt Me Me CH48 Q.sub.1 H COOEt Me OMe CH49 Q.sub.1 H COOEt OMe OMe CH50 Q.sub.1 H COOEt Me Me N51 Q.sub.1 H COOEt Me OMe N52 Q.sub.1 H COOEt OMe OMe N53 Q.sub.1 H COOEt Me Cl CH54 Q.sub.1 H COOEt Me OEt CH55 Q.sub.1 H COOEt Me H CH56 Q.sub.1 H COOEt Me CH.sub.2 OMe CH57 Q.sub.1 H COOEt Me CF.sub.3 CH58 Q.sub.1 H COOEt Me OCH.sub.2 CF.sub.3 CH59 Q.sub.1 H COOEt Me OCH.sub.2 COOMe CH60 Q.sub.1 H COOEt Cl Cl CH61 Q.sub.1 H COOEt Br Br CH62 Q.sub.1 H COOEt Me Cl N63 Q.sub.1 H COOEt Cl NMe.sub.2 N64 Q.sub.1 H COOEt OMe NMe.sub.2 N65 Q.sub.1 H COOEt Me OEt N66 Q.sub.1 H COOEt Me NHEt N67 Q.sub.1 H COOEt Me CH.sub.2 OMe N68 Q.sub.1 H COOEt Me OCH(Me)COOH N69 Q.sub.1 H COOEt Me COOMe CH70 Q.sub.1 H COOEt Me COOEt CH71 Q.sub.1 H COOEt OMe COOMe CH72 Q.sub.1 H COOEt Cl COOMe CH73 Q.sub.1 H COOEt Me ##STR17## CH74 Q.sub.1 H COOEt Me OCHF.sub.2 CH75 Q.sub.1 H COOEt OCHF.sub.2 OCHF.sub.2 CH76 Q.sub.1 H COOEt Cl OCHF.sub.2 CH77 Q.sub.1 H COOEt Cl OMe CH78 Q.sub.1 H COOEt Cl NH.sub.2 CH79 Q.sub.1 H COOEt Me Me CMe80 Q.sub.1 H COOEt Me Me CCl81 Q.sub.1 H COOEt Me OMe CCl82 Q.sub.1 H COOEt OMe OMe CF83 Q.sub.1 H COOEt Me Me COMe84 Q.sub.1 H COOEt OMe OMe CCF.sub.385 Q.sub.1 H COOEt Me N(Me)OMe CH86 Q.sub.1 H COOEt Me SMe CH87 Q.sub.1 H COOEt Me CH(OMe).sub.2 CH88 Q.sub.1 H COOEt OMe CH(OEt).sub.2 N89 Q.sub.1 H COOEt OMe ##STR18## N90 Q.sub.1 H COOEt Me SCHF.sub.2 CH91 Q.sub.1 H COOEt Me SCHF.sub.2 N92 Q.sub.1 H COOEt Me OCF.sub.2 CF.sub.2 H CH93 Q.sub.1 H COOH Me Me CH94 Q.sub.1 H COOH Me OMe CH95 Q.sub.1 H COOH OMe OMe CH96 Q.sub.1 H COOH Me OMe N97 Q.sub.1 H COOH OMe OMe N98 Q.sub.1 H COOPrn Me Me CH99 Q.sub.1 H COOPrn Me OMe CH100 Q.sub.1 H COOPrn OMe OMe CH101 Q.sub.1 H COOPrn Me OMe N102 Q.sub.1 H COOPrn OMe OMe N103 Q.sub.1 H COOPri Me Me CH104 Q.sub.1 H COOPri Me OMe CH105 Q.sub.1 H COOPri OMe OMe CH106 Q.sub.1 H COOPri Me OMe N107 Q.sub.1 H COOPri OMe OMe N108 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl Me Me CH109 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH110 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH111 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl Me OMe N112 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl OMe OMe N113 Q.sub.1 H COOCH.sub.2 CF.sub.3 Me OMe CH114 Q.sub.1 H COOCH.sub.2 CF.sub.3 OMe OMe CH115 Q.sub.1 H COOCH.sub.2 CF.sub.3 Me OMe N116 Q.sub.1 H COOBun Me OMe CH117 Q.sub.1 H COOBun OMe OMe CH118 Q.sub.1 H COOBun Me OMe N119 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 Me Me CH120 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 Me OMe CH121 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH122 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 Me OMe N123 Q.sub.1 H COOCH.sub.2 CHCH.sub. 2 OMe OMe N124 Q.sub.1 H COOCH.sub.2 CCH Me Me CH125 Q.sub.1 H COOCH.sub.2 CCH Me OMe CH126 Q.sub.1 H COOCH.sub.2 CCH OMe OMe CH127 Q.sub.1 H COOCH.sub.2 CCH Me OMe N128 Q.sub.1 H COOCH.sub.2 CCH OMe OMe N129 Q.sub.1 H COOCH.sub.2 CH.sub.2 OMe Me OMe CH130 Q.sub.1 H COOCH.sub.2 CH.sub.2 OMe OMe OMe CH131 Q.sub.1 H COOCH.sub.2 CH.sub.2 OMe Me OMe N132 Q.sub.1 Me COOMe Me Me CH133 Q.sub.1 Me COOMe Me OMe CH134 Q.sub.1 Me COOMe OMe OMe CH135 Q.sub.1 Me COOMe Me OMe N136 Q.sub.1 Me COOMe OMe OMe N137 Q.sub.1 Me COOEt Me Me CH138 Q.sub.1 Me COOEt Me OMe CH139 Q.sub.1 Me COOEt OMe OMe CH140 Q.sub.1 Me COOEt Me OMe N141 Q.sub.1 Me COOEt OMe OMe N142 Q.sub.1 Et COOMe Me OMe CH143 Q.sub.1 Et COOMe OMe OMe CH144 Q.sub.1 Et COOMe Me OMe N145 Q.sub.1 Et COOEt Me OMe CH146 Q.sub.1 Et COOEt OMe OMe CH147 Q.sub.1 Et COOEt Me OMe N148 Q.sub.1 Cl COOMe Me Me CH149 Q.sub.1 Cl COOMe Me OMe CH150 Q.sub.1 Cl COOMe OMe OMe CH151 Q.sub.1 Cl COOMe Me OMe N152 Q.sub.1 Cl COOMe OMe OMe N153 Q.sub.1 Cl COOEt Me Me CH154 Q.sub.1 Cl COOEt Me OMe CH155 Q.sub.1 Cl COOEt OMe OMe CH156 Q.sub.1 Cl COOEt Me OMe N157 Q.sub.1 Cl COOEt OMe OMe N158 Q.sub.1 F COOMe Me Me CH159 Q.sub.1 F COOMe Me OMe CH160 Q.sub.1 F COOMe OMe OMe CH161 Q.sub.1 F COOMe Me OMe N162 Q.sub.1 F COOMe OMe OMe N163 Q.sub.1 Br COOMe Me Me CH164 Q.sub.1 Br COOMe Me OMe CH165 Q.sub.1 Br COOMe OMe OMe CH166 Q.sub.1 Br COOMe Me OMe N167 Q.sub.1 Br COOMe OMe OMe N168 Q.sub.1 OMe COOMe Me Me CH169 Q.sub.1 OMe COOMe Me OMe CH170 Q.sub.1 OMe COOMe OMe OMe CH171 Q.sub.1 OMe COOMe Me OMe N172 Q.sub.1 OMe COOMe OMe OMe N173 Q.sub.1 OMe COOEt Me Me CH174 Q.sub.1 OMe COOEt Me OMe CH175 Q.sub.1 OMe COOEt OMe OMe CH176 Q.sub.1 OMe COOEt Me OMe N177 Q.sub.1 OMe COOEt OMe OMe N178 Q.sub.1 OEt COOMe Me Me CH179 Q.sub.1 OEt COOMe Me OMe CH180 Q.sub.1 OEt COOMe OMe OMe CH181 Q.sub.1 OEt COOMe OMe OMe N182 Q.sub.1 CF.sub.3 COOMe Me OMe CH183 Q.sub.1 CF.sub.3 COOMe OMe OMe CH184 Q.sub.1 CF.sub.3 COOMe Me OMe N185 Q.sub.1 SMe COOMe Me OMe CH186 Q.sub.1 SMe COOMe OMe OMe CH187 Q.sub.1 SMe COOMe Me OMe N188 Q.sub.1 SO.sub.2 Me COOMe Me OMe CH189 Q.sub.1 SO.sub.2 Me COOMe OMe OMe CH190 Q.sub.1 SO.sub.2 Me COOMe Me OMe N191 Q.sub.1 CO.sub.2 Me COOMe Me OMe CH192 Q.sub.1 CO.sub.2 Me COOMe OMe OMe CH193 Q.sub.1 CO.sub.2 Me COOMe Me OMe N194 Q.sub.1 CH.sub.2 OMe COOMe Me Me CH195 Q.sub.1 CH.sub.2 OMe COOMe Me OMe CH196 Q.sub.1 CH.sub.2 OMe COOMe OMe OMe CH197 Q.sub.1 CH.sub.2 OMe COOMe Me OMe N198 Q.sub.1 CH.sub.2 OMe COOMe OMe OMe N199 Q.sub.1 NO.sub.2 COOMe Me Me CH200 Q.sub.1 NO.sub.2 COOMe Me OMe CH201 Q.sub.1 NO.sub.2 COOMe OMe OMe CH202 Q.sub.1 NO.sub.2 COOMe Me OMe N203 Q.sub.1 NO.sub.2 COOMe OMe OMe N204 Q.sub.1 OH COOMe Me OMe CH205 Q.sub.1 OH COOMe OMe OMe CH206 Q.sub.1 OH COOMe Me OMe N207 Q.sub.1 H Cl Me Me CH208 Q.sub.1 H Cl Me OMe CH209 Q.sub.1 H Cl OMe OMe CH210 Q.sub.1 H Cl Me OMe N211 Q.sub.1 H Cl OMe OMe N212 Q.sub.1 H Br Me OMe CH213 Q.sub.1 H Br OMe OMe CH214 Q.sub.1 H Br OMe OMe N215 Q.sub.1 H Br Me OMe N216 Q.sub.1 Me Cl Me Me CH217 Q.sub.1 Me Cl Me OMe CH218 Q.sub.1 Me Cl OMe OMe CH219 Q.sub.1 Me Cl Me OMe N220 Q.sub.1 Me Cl OMe OMe N221 Q.sub.1 H NO.sub.2 Me Me N222 Q.sub.1 H NO.sub.2 Me Me CH223 Q.sub.1 H NO.sub.2 Me OMe CH224 Q.sub.1 H NO.sub.2 OMe OMe CH225 Q.sub.1 H NO.sub.2 Me OMe N226 Q.sub.1 H NO.sub.2 OMe OMe N227 Q.sub.1 Me NO.sub.2 Me OMe CH228 Q.sub.1 Me NO.sub.2 OMe OMe CH229 Q.sub.1 Me NO.sub.2 Me OMe N230 Q.sub.1 H OMe Me OMe CH231 Q.sub.1 H OMe OMe OMe CH232 Q.sub.1 H OMe Me OMe N233 Q.sub.1 H OEt Me OMe CH234 Q.sub.1 H OEt OMe OMe CH235 Q.sub.1 H OEt Me OMe N236 Q.sub.1 Me OMe Me OMe CH237 Q.sub.1 Me OMe OMe OMe CH238 Q.sub.1 Me OMe Me OMe N239 Q.sub.1 H CONMe.sub.2 Me OMe CH240 Q.sub.1 H CONMe.sub.2 OMe OMe CH241 Q.sub.1 H CONMe.sub.2 Me OMe N242 Q.sub.1 H CONEt.sub.2 Me OMe CH243 Q.sub.1 H CONEt.sub.2 OMe OMe CH244 Q.sub.1 H CONEt.sub.2 Me OMe N245 Q.sub.1 H CONHMe Me OMe CH246 Q.sub.1 H CONHMe OMe OMe CH247 Q.sub.1 H CONHMe Me OMe N248 Q.sub.1 H CONHPh Me OMe CH249 Q.sub.1 H CONHPh OMe OMe CH250 Q.sub.1 H CONHPh Me OMe N251 Q.sub.1 H CON(Me)OMe Me OMe CH252 Q.sub.1 H CON(Me)OMe OMe OMe CH253 Q.sub.1 H CON(Me)OMe Me OMe N254 Q.sub.1 H SMe Me OMe CH255 Q.sub.1 H SMe OMe OMe CH256 Q.sub.1 H SMe Me OMe N257 Q.sub.1 H SO.sub.2 Me Me OMe CH258 Q.sub.1 H SO.sub. 2 Me OMe OMe CH259 Q.sub.1 H SO.sub.2 Me Me OMe N260 Q.sub.1 H SO.sub.2 Et Me OMe CH261 Q.sub.1 H SO.sub.2 Et OMe OMe CH262 Q.sub.1 H SO.sub.2 Et Me OMe N263 Q.sub.1 H SO.sub.3 Me Me OMe CH264 Q.sub.1 H SO.sub.3 Me OMe OMe CH265 Q.sub.1 H SO.sub.3 Me Me OMe N266 Q.sub.1 H SO.sub.2 Ph Me OMe CH267 Q.sub.1 H SO.sub.2 Ph OMe OMe CH268 Q.sub.1 H SO.sub.2 Ph Me OMe N269 Q.sub.1 H SO.sub.2 NMe.sub.2 Me Me CH270 Q.sub.1 H SO.sub.2 NMe.sub.2 Me OMe CH271 Q.sub.1 H SO.sub.2 NMe.sub.2 OMe OMe CH272 Q.sub.1 H SO.sub.2 NMe.sub.2 Me OMe N273 Q.sub.1 H SO.sub.2 NMe.sub.2 OMe OMe N274 Q.sub.1 H SO.sub.2 NEt.sub.2 Me OMe CH275 Q.sub.1 H SO.sub.2 NEt.sub.2 OMe OMe CH276 Q.sub.1 H SO.sub.2 NEt.sub.2 Me OMe N277 Q.sub.1 H SO.sub.2 NHMe Me OMe CH278 Q.sub.1 H SO.sub.2 NHMe OMe OMe CH279 Q.sub.1 H SO.sub.2 NHMe Me OMe N280 Q.sub.1 H SO.sub.2 NHPh Me OMe CH281 Q.sub.1 H SO.sub.2 NHPh OMe OMe CH282 Q.sub.1 H SO.sub.2 NHPh Me OMe N283 Q.sub.1 Me SO.sub.2 NMe.sub.2 Me OMe CH284 Q.sub.1 Me SO.sub.2 NMe.sub.2 OMe OMe CH285 Q.sub.1 Me SO.sub.2 NMe.sub.2 Me OMe N286 Q.sub.1 H CN Me Me CH287 Q.sub.1 H CN Me OMe CH288 Q.sub.1 H CN OMe OMe CH289 Q.sub.1 H CN Me OMe N290 Q.sub.1 H CN OMe OMe N291 Q.sub.1 Me CN Me Me CH292 Q.sub.1 Me CN Me OMe CH293 Q.sub.1 Me CN OMe OMe CH294 Q.sub.1 Me CN Me OMe N295 Q.sub.1 Me CN OMe OMe N296 Q.sub.1 H NMe.sub.2 Me Me CH297 Q.sub.1 H NMe.sub.2 Me OMe CH298 Q.sub.1 H NMe.sub.2 OMe OMe CH299 Q.sub.1 H NMe.sub.2 Me OMe N300 Q.sub.1 H NMe.sub.2 OMe OMe N301 Q.sub.1 H NHCOMe Me OMe CH302 Q.sub.1 H NHCOMe OMe OMe CH303 Q.sub.1 H NHCOMe Me OMe N304 Q.sub.1 H Me Me Me CH305 Q.sub.1 H Me Me OMe CH306 Q.sub.1 H Me OMe OMe CH307 Q.sub.1 H Me Me OMe N308 Q.sub.1 H Me OMe OMe N309 Q.sub.1 H Et Me Me CH310 Q.sub.1 H Et Me OMe CH311 Q.sub.1 H Et OMe OMe CH312 Q.sub.1 H Et Me OMe N313 Q.sub.1 H Et OMe OMe N314 Q.sub.1 H Prn Me OMe CH315 Q.sub.1 H Prn OMe OMe CH316 Q.sub.1 H Prn Me OMe N317 Q.sub.1 Me H Me Me CH318 Q.sub.1 Me H Me OMe CH319 Q.sub.1 Me H OMe OMe CH320 Q.sub.1 Me H Me OMe N321 Q.sub.1 Me H OMe OMe N322 Q.sub.1 H H Me Me CH323 Q.sub.1 H H Me OMe CH324 Q.sub. 1 H H OMe OMe CH325 Q.sub.1 H H Me OMe N326 Q.sub.1 H H OMe OMe N327 Q.sub.1 H COPh Me Me CH328 Q.sub.1 H COPh Me OMe CH329 Q.sub.1 H COPh OMe OMe CH330 Q.sub.1 H COPh Me OMe N331 Q.sub.1 H COPh OMe OMe N332 Q.sub.1 Me COPh Me Me CH333 Q.sub.1 Me COPh Me OMe CH334 Q.sub.1 Me COPh OMe OMe CH335 Q.sub.1 Me COPh Me OMe N336 Q.sub.1 Me COPh OMe OMe N337 Q.sub.1 H COPh2,4Cl.sub.2 Me OMe CH338 Q.sub.1 H COPh2,4Cl.sub.2 OMe OMe CH339 Q.sub.1 H COPh2,4Cl.sub.2 Me OMe N340 Q.sub.1 H COPh2Me Me OMe CH341 Q.sub.1 H COPh2Me OMe OMe CH342 Q.sub.1 H COPh2Me Me OMe N343 H Q.sub.1 H Me Me CH344 H Q.sub.1 H Me OMe CH345 H Q.sub.1 H OMe OMe CH346 H Q.sub.1 H Me OMe N347 H Q.sub.1 H OMe OMe N348 Me Q.sub.1 H Me Me CH349 Me Q.sub.1 H Me OMe CH350 Me Q.sub.1 H OMe OMe CH351 Me Q.sub.1 H Me OMe N352 Me Q.sub.1 H OMe OMe N353 H Q.sub.1 Me Me Me CH354 H Q.sub.1 Me Me OMe CH355 H Q.sub.1 Me OMe OMe CH356 H Q.sub.1 Me Me OMe N357 H Q.sub.1 Me OMe OMe N358 Me Q.sub.1 Me Me Me CH359 Me Q.sub.1 Me Me OMe CH360 Me Q.sub.1 Me OMe OMe CH361 Me Q.sub.1 Me Me OMe N362 Me Q.sub.1 Me OMe OMe N363 H Q.sub.1 COOMe Me Me CH364 H Q.sub.1 COOMe Me OMe CH365 H Q.sub.1 COOMe OMe OMe CH366 H Q.sub.1 COOMe Me OMe N367 H Q.sub.1 COOMe OMe OMe N368 H Q.sub.1 COOEt Me Me CH369 H Q.sub.1 COOEt Me OMe CH370 H Q.sub.1 COOEt OMe OMe CH371 H Q.sub.1 COOEt Me OMe N372 H Q.sub.1 COOEt OMe OMe N373 Me Q.sub.1 COOMe Me Me CH374 Me Q.sub.1 COOMe Me OMe CH375 Me Q.sub.1 COOMe OMe OMe CH376 Me Q.sub.1 COOMe Me OMe N377 Me Q.sub.1 COOMe OMe OMe N378 Me Q.sub.1 COOEt Me Me CH379 Me Q.sub.1 COOEt Me OMe CH380 Me Q.sub.1 COOEt OMe OMe CH381 Me Q.sub.1 COOEt Me OMe N382 Me Q.sub.1 COOEt OMe OMe N383 CH.sub.2 OCH.sub.3 Q.sub.1 COOMe Me OMe CH384 CH.sub.2 OCH.sub.3 Q.sub.1 COOMe OMe OMe CH385 CH.sub.2 OCH.sub.3 Q.sub.1 COOMe Me OMe N386 CH.sub.2 SCH.sub.3 Q.sub.1 COOMe Me OMe CH387 CH.sub.2 SCH.sub.3 Q.sub.1 COOMe OMe OMe CH388 CH.sub.2 SCH.sub.3 Q.sub.1 COOMe Me OMe N389 Me Q.sub.1 SO.sub.2 NMe.sub.2 Me OMe CH390 Me Q.sub.1 SO.sub.2 NMe.sub.2 OMe OMe CH391 Me Q.sub.1 SO.sub.2 NMe.sub.2 Me OMe N392 Me Q.sub.1 NO.sub.2 Me OMe CH393 Me Q.sub.1 NO.sub.2 OMe OMe CH394 Me Q.sub.1 NO.sub.2 Me OMe N395 Me Q.sub.1 OMe Me OMe CH396 Me Q.sub.1 OMe OMe OMe CH397 Me Q.sub.1 OMe Me OMe N398 Me Q.sub.1 CN Me OMe CH399 Me Q.sub.1 CN OMe OMe CH400 Me Q.sub.1 CN Me OMe N401 H H Q.sub.1 Me Me CH402 H H Q.sub.1 Me OMe CH403 H H Q.sub.1 OMe OMe CH404 H H Q.sub.1 Me OMe N405 H H Q.sub.1 OMe OMe N406 Me H Q.sub.1 Me Me CH407 Me H Q.sub.1 Me OMe CH408 Me H Q.sub.1 OMe OMe CH409 Me H Q.sub.1 Me OMe N410 Me H Q.sub.1 OMe OMe N411 Et H Q.sub.1 Me OMe CH412 Et H Q.sub.1 OMe OMe CH413 Et H Q.sub.1 Me OMe N414 CH.sub.2 CHCH.sub.2 H Q.sub.1 Me OMe CH415 CH.sub.2 CHCH.sub.2 H Q.sub.1 OMe OMe CH416 CH.sub.2 CHCH.sub.2 H Q.sub.1 Me OMe N417 CH.sub.2 C CH H Q.sub.1 Me OMe CH418 CH.sub.2 CCH H Q.sub.1 OMe OMe CH419 CH.sub.2 CCH H Q.sub.1 Me OMe N420 CH.sub.2 CN H Q.sub.1 Me OMe CH421 CH.sub.2 CN H Q.sub.1 OMe OMe CH422 CH.sub.2 CN H Q.sub.1 Me OMe N423 CH.sub.2 COOMe H Q.sub.1 Me OMe CH424 CH.sub.2 COOMe H Q.sub.1 OMe OMe CH425 CH.sub.2 COOMe H Q.sub.1 Me OMe N426 CH.sub.2 COOEt H Q.sub.1 Me Me CH427 CH.sub.2 COOEt H Q.sub.1 Me OMe CH428 CH.sub.2 COOEt H Q.sub.1 OMe OMe CH429 CH.sub.2 COOEt H Q.sub.1 Me OMe N430 CH.sub.2 COOEt H Q.sub.1 OMe OMe N431 CH.sub.2 OMe H Q.sub.1 Me Me CH432 CH.sub.2 OMe H Q.sub.1 Me OMe CH433 CH.sub.2 OMe H Q.sub.1 OMe OMe CH434 CH.sub.2 OMe H Q.sub.1 Me OMe N435 CH.sub.2 OMe H Q.sub.1 OMe OMe N436 CH.sub.2 SMe H Q.sub.1 Me Me CH437 CH.sub.2 SMe H Q.sub.1 Me OMe CH438 CH.sub.2 SMe H Q.sub.1 OMe OMe CH439 CH.sub.2 SMe H Q.sub.1 Me OMe N440 CH.sub.2 SMe H Q.sub.1 OMe OMe N441 SO.sub.2 NMe.sub.2 H Q.sub.1 Me Me CH442 SO.sub.2 NMe.sub.2 H Q.sub.1 Me OMe CH443 SO.sub.2 NMe.sub.2 H Q.sub.1 OMe OMe CH444 SO.sub.2 NMe.sub.2 H Q.sub.1 Me OMe N445 SO.sub.2 NMe.sub.2 H Q.sub.1 OMe OMe N446 SO.sub.2 Me H Q.sub.1 Me Me CH447 SO.sub.2 Me H Q.sub.1 Me OMe CH448 SO.sub.2 Me H Q.sub.1 OMe OMe CH449 SO.sub.2 Me H Q.sub.1 Me OMe N450 SO.sub.2 Me H Q.sub.1 OMe OMe N451 Ph H Q.sub.1 Me Me CH452 Ph H Q.sub.1 Me OMe CH453 Ph H Q.sub.1 OMe OMe CH454 Ph H Q.sub.1 Me OMe N455 Ph H Q.sub.1 OMe OMe N456 Ph2-Cl H Q.sub.1 Me OMe CH457 Ph2-Cl H Q.sub.1 OMe OMe CH458 Ph2-Cl H Q.sub.1 Me OMe N459 Ph2-Me H Q.sub.1 Me OMe CH460 Ph2-Me H Q.sub.1 OMe OMe CH461 Ph2-Me H Q.sub.1 Me OMe N462 Ph2-COOMe H Q.sub.1 Me OMe CH463 Ph2-COOMe H Q.sub.1 OMe OMe CH464 Ph2-COOMe H Q.sub.1 Me OMe N465 H Me Q.sub.1 Me Me CH466 H Me Q.sub.1 Me OMe CH467 H Me Q.sub.1 OMe OMe CH468 H Me Q.sub.1 Me OMe N469 H Me Q.sub.1 OMe OMe N470 Me Me Q.sub.1 Me Me CH471 Me Me Q.sub.1 Me OMe CH472 Me Me Q.sub.1 OMe OMe CH473 Me Me Q.sub.1 Me OMe N474 Me Me Q.sub.1 OMe OMe N475 Ph Me Q.sub.1 Me Me CH476 Ph Me Q.sub.1 Me OMe CH477 Ph Me Q.sub.1 OMe OMe CH478 Ph Me Q.sub.1 Me OMe N479 Ph Me Q.sub.1 OMe OMe N480 Q.sub.1 H COOMe Me OCH.sub.2 CH.sub.2 C481 Q.sub.1 H COOEt Me OCH.sub.2 CH.sub.2 C482 Q.sub.2 H COOMe Me Me CH483 Q.sub.2 H COOMe Me OMe CH484 Q.sub.2 H COOMe OMe OMe CH485 Q.sub.2 H COOMe Me Me N486 Q.sub.2 H COOMe Me OMe N487 Q.sub.2 H COOMe OMe OMe N488 Q.sub.2 H COOMe Me OCHF.sub.2 CH489 Q.sub.2 H COOMe Cl OMe CH490 Q.sub.2 H COOEt Me Me CH491 Q.sub.2 H COOEt Me OMe CH492 Q.sub.2 H COOEt OMe OMe CH493 Q.sub.2 H COOEt Me Me N494 Q.sub.2 H COOEt Me OMe N495 Q.sub.2 H COOEt OMe OMe N496 Q.sub.2 H COOEt Me OCHF.sub.2 CH497 Q.sub.2 H COOEt Cl OMe CH498 Q.sub.2 H COOPrn Me OMe CH499 Q.sub. 2 H COOPrn OMe OMe CH500 Q.sub.2 H COOPrn Me OMe N501 Q.sub.2 H COOPri Me OMe CH502 Q.sub.2 H COOPri OMe OMe CH503 Q.sub.2 H COOPri Me OMe N504 Q.sub.2 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH505 Q.sub.2 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH506 Q.sub.2 H COOCH.sub.2 CH.sub.2 Cl Me OMe N507 Q.sub.2 H COOCH.sub.2 CHCH.sub.2 Me OMe CH508 Q.sub.2 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH509 Q.sub.2 H COOCH.sub.2 CHCH.sub.2 Me OMe N510 Q.sub.2 H COOCH.sub.2 CCH Me OMe CH511 Q.sub.2 H COOCH.sub.2 CCH OMe OMe CH512 Q.sub.2 H COOCH.sub.2 CCH Me OMe N513 Q.sub.2 Me COOMe Me Me CH514 Q.sub.2 Me COOMe Me OMe CH515 Q.sub.2 Me COOMe OMe OMe CH516 Q.sub.2 Me COOMe Me OMe N517 Q.sub.2 Me COOMe OMe OMe N518 Q.sub.2 Me COOEt Me Me CH519 Q.sub.2 Me COOEt Me OMe CH520 Q.sub.2 Me COOEt OMe OMe CH521 Q.sub.2 Me COOEt Me OMe N522 Q.sub.2 Me COOEt OMe OMe N523 Q.sub.2 Cl COOMe Me OMe CH524 Q.sub.2 Cl COOMe OMe OMe CH525 Q.sub.2 Cl COOMe Me OMe N526 Q.sub.2 Cl COOEt Me OMe CH527 Q.sub.2 Cl COOEt OMe OMe CH528 Q.sub.2 Cl COOEt Me OMe N529 Q.sub.2 OMe COOMe Me OMe CH530 Q.sub.2 OMe COOMe OMe OMe CH531 Q.sub.2 OMe COOMe Me OMe N532 Q.sub.2 OMe COOEt Me OMe CH533 Q.sub.2 OMe COOEt OMe OMe CH534 Q.sub.2 OMe COOEt Me OMe N535 Q.sub.2 H Cl Me OMe CH536 Q.sub.2 H Cl OMe OMe CH537 Q.sub.2 H Cl Me OMe N538 Q.sub.2 H NO.sub.2 Me OMe CH539 Q.sub.2 H NO.sub.2 OMe OMe CH540 Q.sub.2 H NO.sub.2 Me OMe N541 Q.sub.2 H SO.sub.2 NMe.sub.2 Me OMe CH542 Q.sub.2 H SO.sub.2 NMe.sub.2 OMe OMe CH543 Q.sub.2 H SO.sub.2 NMe.sub.2 Me OMe N544 Q.sub.2 H CN Me OMe CH545 Q.sub.2 H CN OMe OMe CH546 Q.sub.2 H CN Me OMe N547 Q.sub.2 Me CN Me OMe CH548 Q.sub.2 Me CN OMe OMe CH549 Q.sub.2 Me CN Me OMe N550 Q.sub.2 H Me Me OMe CH551 Q.sub.2 H Me OMe OMe CH552 Q.sub.2 H Me Me OMe N553 Q.sub.2 H Et Me OMe CH554 Q.sub.2 H Et OMe OMe CH555 Q.sub.2 H Et Me OMe N556 Q.sub.2 H H Me OMe CH557 Q.sub.2 H H OMe OMe CH558 Q.sub.2 H H Me OMe N559 Q.sub.2 H COPh Me OMe CH560 Q.sub.2 H COPh OMe OMe CH561 Q.sub.2 H COPh Me OMe N562 Me Q.sub.2 COOMe Me OMe CH563 Me Q.sub.2 COOMe OMe OMe CH564 Me Q.sub.2 COOMe Me OMe N565 H H Q.sub.2 Me OMe CH566 H H Q.sub.2 OMe OMe CH567 H H Q.sub.2 Me OMe N568 Me H Q.sub.2 Me Me CH569 Me H Q.sub.2 Me OMe CH570 Me H Q.sub.2 OMe OMe CH571 Me H Q.sub.2 Me OMe N572 Me H Q.sub.2 OMe OMe N573 Me Me Q.sub.2 Me OMe CH574 Me Me Q.sub.2 OMe OMe CH575 Me Me Q.sub.2 Me OMe N576 Q.sub.3 H COOMe Me Me CH577 Q.sub.3 H COOMe Me OMe CH578 Q.sub.3 H COOMe OMe OMe CH579 Q.sub.3 H COOMe Me OMe N580 Q.sub.3 H COOMe OMe OMe N581 Q.sub.3 H COOEt Me Me CH582 Q.sub.3 H COOEt Me OMe CH583 Q.sub.3 H COOEt OMe OMe CH584 Q.sub.3 H COOEt Me OMe N585 Q.sub.3 H COOEt OMe OMe N586 Q.sub.3 Me COOMe Me OMe CH587 Q.sub.3 Me COOMe OMe OMe CH588 Q.sub.3 Me COOMe Me OMe N589 Q.sub.3 Me COOEt Me OMe CH590 Q.sub.3 Me COOEt OMe OMe CH591 Q.sub.3 Me COOEt Me OMe N592 Q.sub.3 H CN Me OMe CH593 Q.sub.3 H CN OMe OMe CH594 Q.sub.3 H CN Me OMe N595 Q.sub.3 H H Me OMe CH596 Q.sub.3 H H OMe OMe CH597 Q.sub.3 H H Me OMe N598 Me H Q.sub.3 Me Me CH599 Me H Q.sub.3 Me OMe CH600 Me H Q.sub.3 OMe OMe CH601 Me H Q.sub.3 Me OMe N602 Me H Q.sub.3 OMe OMe N603 Q.sub.4 H COOMe Me Me CH604 Q.sub.4 H COOMe Me OMe CH605 Q.sub.4 H COOMe OMe OMe CH606 Q.sub.4 H COOMe Me OMe N607 Q.sub.4 H COOMe OMe OMe N608 Q.sub.4 H COOEt Me Me CH609 Q.sub.4 H COOEt Me OMe CH610 Q.sub.4 H COOEt OMe OMe CH611 Q.sub.4 H COOEt Me OMe N612 Q.sub.4 H COOEt OMe OMe N613 Q.sub.4 Me COOMe Me OMe CH614 Q.sub.4 Me COOMe OMe OMe CH615 Q.sub.4 Me COOMe Me OMe N616 Q.sub.4 Me COOEt Me OMe CH617 Q.sub.4 Me COOEt OMe OMe CH618 Q.sub.4 Me COOEt Me OMe N619 Q.sub.4 H CN Me OMe CH620 Q.sub.4 H CN OMe OMe CH621 Q.sub.4 H CN Me OMe N622 Q.sub.4 H H Me OMe CH623 Q.sub.4 H H OMe OMe CH624 Q.sub.4 H H Me OMe N625 Me H Q.sub.4 Me Me CH626 Me H Q.sub.4 Me OMe CH627 Me H Q.sub.4 OMe OMe CH628 Me H Q.sub.4 Me OMe N629 Me H Q.sub.4 OMe OMe N630 Q.sub.5 H COOMe Me Me CH631 Q.sub.5 H COOMe Me OMe CH632 Q.sub.5 H COOMe OMe OMe CH633 Q.sub.5 H COOMe Me Me N634 Q.sub.5 H COOMe Me OMe N635 Q.sub.5 H COOMe OMe OMe N636 Q.sub.5 H COOMe Me OCHF.sub.2 CH637 Q.sub.5 H COOMe Cl OMe CH638 Q.sub.5 H COOEt Me Me CH639 Q.sub.5 H COOEt Me OMe CH640 Q.sub.5 H COOEt OMe OMe CH641 Q.sub.5 H COOEt Me Me N642 Q.sub.5 H COOEt Me OMe N643 Q.sub.5 H COOEt OMe OMe N644 Q.sub.5 H COOEt Me OCHF.sub.2 CH645 Q.sub.5 H COOEt Cl OMe CH646 Q.sub.5 H COOPrn Me OMe CH647 Q.sub.5 H COOPrn OMe OMe CH648 Q.sub.5 H COOPrn Me OMe N649 Q.sub.5 H COOPri Me OMe CH650 Q.sub.5 H COOPri OMe OMe CH651 Q.sub.5 H COOPri Me OMe N652 Q.sub.5 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH653 Q.sub.5 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH654 Q.sub.5 H COOCH.sub.2 CH.sub.2 Cl Me OMe N655 Q.sub.5 H COOCH.sub.2 CHCH.sub.2 Me OMe CH656 Q.sub.5 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH657 Q.sub.5 H COOCH.sub.2 CHCH.sub.2 Me OMe N658 Q.sub.5 H COOCH.sub.2 CCH Me OMe CH659 Q.sub.5 H COOCH.sub.2 CCH OMe OMe CH660 Q.sub.5 H COOCH.sub.2 CCH Me OMe N661 Q.sub.5 Me COOMe Me Me CH662 Q.sub.5 Me COOMe Me OMe CH663 Q.sub.5 Me COOMe OMe OMe CH664 Q.sub.5 Me COOMe Me OMe N665 Q.sub.5 Me COOMe OMe OMe N666 Q.sub.5 Me COOEt Me Me CH667 Q.sub.5 Me COOEt Me OMe CH668 Q.sub.5 Me COOEt OMe OMe CH669 Q.sub.5 Me COOEt Me OMe N670 Q.sub.5 Me COOEt OMe OMe N671 Q.sub.5 Cl COOMe Me OMe CH672 Q.sub.5 Cl COOMe OMe OMe CH673 Q.sub.5 Cl COOMe Me OMe N674 Q.sub.5 Cl COOEt Me OMe CH675 Q.sub.5 Cl COOEt OMe OMe CH676 Q.sub.5 Cl COOEt Me OMe N677 Q.sub.5 OMe COOMe Me OMe CH678 Q.sub.5 OMe COOMe OMe OMe CH679 Q.sub.5 OMe COOMe Me OMe N680 Q.sub.5 OMe COOEt Me OMe CH681 Q.sub.5 OMe COOEt OMe OMe CH682 Q.sub.5 OMe COOEt Me OMe N683 Q.sub.5 H Cl Me OMe CH684 Q.sub.5 H Cl OMe OMe CH685 Q.sub.5 H Cl Me OMe N686 Q.sub.5 H NO.sub.2 Me OMe CH687 Q.sub.5 H NO.sub.2 OMe OMe CH688 Q.sub.5 H NO.sub.2 Me OMe N689 Q.sub.5 H SO.sub.2 NMe.sub.2 Me OMe CH690 Q.sub.5 H SO.sub.2 NMe.sub.2 OMe OMe CH691 Q.sub.5 H SO.sub.2 NMe.sub.2 Me OMe N692 Q.sub.5 H CN Me OMe CH693 Q.sub.5 H CN OMe OMe CH694 Q.sub.5 H CN Me OMe N695 Q.sub.5 Me CN Me OMe CH696 Q.sub.5 Me CN OMe OMe CH697 Q.sub.5 Me CN Me OMe N698 Q.sub.5 H Me Me OMe CH699 Q.sub.5 H Me OMe OMe CH700 Q.sub.5 H Me Me OMe N701 Q.sub.5 H Et Me OMe CH702 Q.sub.5 H Et OMe OMe CH703 Q.sub.5 H Et Me OMe N704 Q.sub.5 H H Me OMe CH705 Q.sub.5 H H OMe OMe CH706 Q.sub.5 H H Me OMe N707 Q.sub.5 H COPh Me OMe CH708 Q.sub.5 H COPh OMe OMe CH709 Q.sub.5 H COPh Me OMe N710 Me Q.sub.5 COOMe Me OMe CH711 Me Q.sub.5 COOMe OMe OMe CH712 Me Q.sub.5 COOMe Me OMe N713 H H Q.sub.5 Me OMe CH714 H H Q.sub.5 OMe OMe CH715 H H Q.sub.5 Me OMe N716 Me H Q.sub.5 Me Me CH717 Me H Q.sub.5 Me OMe CH718 Me H Q.sub.5 OMe OMe CH719 Me H Q.sub.5 Me OMe N720 Me H Q.sub.5 OMe OMe N721 Me Me Q.sub.5 Me OMe CH722 Me Me Q.sub.5 OMe OMe CH723 Me Me Q.sub.5 Me OMe N724 Q.sub.6 H COOMe Me Me CH725 Q.sub.6 H COOMe Me OMe CH726 Q.sub.6 H COOMe OMe OMe CH727 Q.sub.6 H COOMe Me OMe N728 Q.sub.6 H COOMe OMe OMe N729 Q.sub.6 H COOEt Me Me CH730 Q.sub.6 H COOEt Me OMe CH731 Q.sub.6 H COOEt OMe OMe CH732 Q.sub.6 H COOEt Me OMe N733 Q.sub.6 H COOEt OMe OMe N734 Q.sub.6 Me COOMe Me OMe CH735 Q.sub.6 Me COOMe OMe OMe CH736 Q.sub.6 Me COOMe Me OMe N737 Q.sub.6 Me COOEt Me OMe CH738 Q.sub.6 Me COOEt OMe OMe CH739 Q.sub.6 Me COOEt Me OMe N740 Q.sub.6 H CN Me OMe CH741 Q.sub.6 H CN OMe OMe CH742 Q.sub.6 H CN Me OMe N743 Q.sub.6 H H Me OMe CH744 Q.sub.6 H H OMe OMe CH745 Q.sub.6 H H Me OMe N746 Me H Q.sub.6 Me Me CH747 Me H Q.sub.6 Me OMe CH748 Me H Q.sub.6 OMe OMe CH749 Me H Q.sub.6 Me OMe N750 Me H Q.sub.6 OMe OMe N751 Q.sub.7 H COOMe Me OMe CH752 Q.sub.7 H COOMe OMe OMe CH753 Q.sub.7 H COOEt Me OMe CH754 Q.sub.7 H COOEt OMe OMe CH755 Q.sub.7 Me COOMe Me OMe CH756 Q.sub.7 Me COOMe OMe OMe CH757 Q.sub.7 Me COOEt Me OMe CH758 Q.sub.7 Me COOEt OMe OMe CH759 Q.sub.7 H H Me OMe CH760 Q.sub.7 H H OMe OMe CH761 Me H Q.sub.7 Me OMe CH762 Me H Q.sub.7 OMe OMe CH763 Q.sub.8 H COOMe Me Me CH764 Q.sub.8 H COOMe Me OMe CH765 Q.sub.8 H COOMe OMe OMe CH766 Q.sub.8 H COOMe Me Me N767 Q.sub.8 H COOMe Me OMe N768 Q.sub.8 H COOMe OMe OMe N769 Q.sub.8 H COOMe Me OCHF.sub.2 CH770 Q.sub.8 H COOMe Cl OMe CH771 Q.sub.8 H COOEt Me Me CH772 Q.sub.8 H COOEt Me OMe CH773 Q.sub.8 H COOEt OMe OMe CH774 Q.sub.8 H COOEt Me Me N775 Q.sub.8 H COOEt Me OMe N776 Q.sub.8 H COOEt OMe OMe N777 Q.sub.8 H COOEt Me OCHF.sub.2 CH778 Q.sub.8 H COOEt Cl OMe CH779 Q.sub.8 H COOPrn Me OMe CH780 Q.sub.8 H COOPrn OMe OMe CH781 Q.sub.8 H COOPrn Me OMe N782 Q.sub.8 H COOPri Me OMe CH783 Q.sub.8 H COOPri OMe OMe CH784 Q.sub.8 H COOPri Me OMe N785 Q.sub.8 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH786 Q.sub.8 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH787 Q.sub.8 H COOCH.sub.2 CH.sub.2 Cl Me OMe N788 Q.sub.8 H COOCH.sub.2 CHCH.sub.2 Me OMe CH789 Q.sub.8 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH790 Q.sub.8 H COOCH.sub.2 CHCH.sub.2 Me OMe N791 Q.sub.8 H COOCH.sub.2 CCH Me OMe CH792 Q.sub.8 H COOCH.sub.2 CCH OMe OMe CH793 Q.sub.8 H COOCH.sub.2 CCH Me OMe N794 Q.sub.8 Me COOMe Me Me CH795 Q.sub.8 Me COOMe Me OMe CH796 Q.sub.8 Me COOMe OMe OMe CH797 Q.sub.8 Me COOMe Me OMe N798 Q.sub.8 Me COOMe OMe OMe N799 Q.sub.8 Me COOEt Me Me CH800 Q.sub.8 Me COOEt Me OMe CH801 Q.sub.8 Me COOEt OMe OMe CH802 Q.sub.8 Me COOEt Me OMe N803 Q.sub.8 Me COOEt OMe OMe N804 Q.sub.8 Cl COOMe Me OMe CH805 Q.sub.8 Cl COOMe OMe OMe CH806 Q.sub.8 Cl COOMe Me OMe N807 Q.sub.8 Cl COOEt Me OMe CH808 Q.sub.8 Cl COOEt OMe OMe CH809 Q.sub.8 Cl COOEt Me OMe N810 Q.sub.8 OMe COOMe Me OMe CH811 Q.sub.8 OMe COOMe OMe OMe CH812 Q.sub.8 OMe COOMe Me OMe N813 Q.sub.8 OMe COOEt Me OMe CH814 Q.sub.8 OMe COOEt OMe OMe CH815 Q.sub.8 OMe COOEt Me OMe N816 Q.sub.8 H Cl Me OMe CH817 Q.sub.8 H Cl OMe OMe CH818 Q.sub.8 H Cl Me OMe N819 Q.sub.8 H NO.sub.2 Me OMe CH820 Q.sub.8 H NO.sub.2 OMe OMe CH821 Q.sub.8 H NO.sub.2 Me OMe N822 Q.sub.8 H SO.sub.2 NMe.sub.2 Me OMe CH823 Q.sub.8 H SO.sub.2 NMe.sub.2 OMe OMe CH824 Q.sub.8 H SO.sub.2 NMe.sub.2 Me OMe N825 Q.sub.8 H CN Me OMe CH826 Q.sub.8 H CN OMe OMe CH827 Q.sub.8 H CN Me OMe N828 Q.sub.8 Me CN Me OMe CH829 Q.sub.8 Me CN OMe OMe CH830 Q.sub.8 Me CN Me OMe N831 Q.sub.8 H Me Me OMe CH832 Q.sub.8 H Me OMe OMe CH833 Q.sub.8 H Me Me OMe N834 Q.sub.8 H Et Me OMe CH835 Q.sub.8 H Et OMe OMe CH836 Q.sub.8 H Et Me OMe N837 Q.sub.8 H H Me OMe CH838 Q.sub.8 H H OMe OMe CH839 Q.sub.8 H H Me OMe N840 Q.sub.8 H COPh Me OMe CH841 Q.sub.8 H COPh OMe OMe CH842 Q.sub.8 H COPh Me OMe N843 Me Q.sub.8 COOMe Me OMe CH844 Me Q.sub.8 COOMe OMe OMe CH845 Me Q.sub.8 COOMe Me OMe N846 H H Q.sub.8 Me OMe CH847 H H Q.sub.8 OMe OMe CH848 H H Q.sub.8 Me OMe N849 Me H Q.sub.8 Me Me CH850 Me H Q.sub.8 Me OMe CH851 Me H Q.sub.8 OMe OMe CH852 Me H Q.sub.8 Me OMe N853 Me H Q.sub.8 OMe OMe N854 Me Me Q.sub.8 Me OMe CH855 Me Me Q.sub.8 OMe OMe CH856 Me Me Q.sub.8 Me OMe N857 Q.sub.9 H COOMe Me Me CH858 Q.sub.9 H COOMe Me OMe CH859 Q.sub.9 H COOMe OMe OMe CH860 Q.sub.9 H COOMe Me OMe N861 Q.sub.9 H COOMe OMe OMe N862 Q.sub.9 H COOEt Me Me CH863 Q.sub.9 H COOEt Me OMe CH__________________________________________________________________________
__________________________________________________________________________864 Q.sub.9 H COOEt OMe OMe CH865 Q.sub.9 H COOEt Me OMe N866 Q.sub.9 H COOEt OMe OMe N867 Q.sub.9 Me COOMe Me OMe CH868 Q.sub.9 Me COOMe OMe OMe CH869 Q.sub.9 Me COOMe Me OMe N870 Q.sub.9 Me COOEt Me OMe CH871 Q.sub.9 Me COOEt OMe OMe CH872 Q.sub.9 Me COOEt Me OMe N873 Q.sub.9 H CN Me OMe CH874 Q.sub.9 H CN OMe OMe CH875 Q.sub.9 H CN Me OMe N876 Q.sub.9 H H Me OMe CH877 Q.sub.9 H H OMe OMe CH878 Q.sub.9 H H Me OMe N879 Me H Q.sub.9 Me Me CH880 Me H Q.sub.9 Me OMe CH881 Me H Q.sub.9 OMe OMe CH882 Me H Q.sub.9 Me OMe N883 Me H Q.sub.9 OMe OMe N884 Me Me Q.sub.9 Me OMe N885 Q.sub.10 H COOMe Me Me CH886 Q.sub.10 H COOMe Me OMe CH887 Q.sub.10 H COOMe OMe OMe CH888 Q.sub.10 H COOMe Me OMe N889 Q.sub.10 H COOMe OMe OMe N890 Q.sub.10 H COOEt Me Me CH891 Q.sub.10 H COOEt Me OMe CH892 Q.sub.10 H COOEt OMe OMe CH893 Q.sub.10 H COOEt Me OMe N894 Q.sub.10 H COOEt OMe OMe N895 Q.sub.10 Me COOMe Me OMe CH895 Q.sub.10 Me COOMe Me OMe CH896 Q.sub.10 Me COOMe OMe OMe CH897 Q.sub.10 Me COOMe Me OMe N898 Q.sub.10 Me COOEt Me OMe CH899 Q.sub.10 Me COOEt OMe OMe CH900 Q.sub.10 Me COOEt Me OMe N901 Q.sub.10 H CN Me OMe CH902 Q.sub.10 H CN OMe OMe CH903 Q.sub.10 H CN Me OMe N904 Q.sub.10 H H Me OMe CH905 Q.sub.10 H H OMe OMe CH906 Q.sub.10 H H Me OMe N907 Me H Q.sub.10 Me Me CH908 Me H Q.sub.10 Me OMe CH909 Me H Q.sub.10 OMe OMe CH910 Me H Q.sub.10 Me OMe N911 Me H Q.sub.10 OMe OMe N912 Q.sub.11 H COOMe Me Me CH913 Q.sub.11 H COOMe Me OMe CH914 Q.sub.11 H COOMe OMe OMe CH915 Q.sub.11 H COOMe Me OMe N916 Q.sub.11 H COOMe OMe OMe N917 Q.sub.11 H COOEt Me Me CH918 Q.sub.11 H COOEt Me OMe CH919 Q.sub.11 H COOEt OMe OMe CH920 Q.sub.11 H COOEt Me OMe N921 Q.sub.11 H COOEt OMe OMe N922 Q.sub.11 Me COOMe Me OMe CH923 Q.sub.11 Me COOMe OMe OMe CH924 Q.sub.11 Me COOMe Me OMe N925 Q.sub.11 Me COOEt Me OMe CH926 Q.sub.11 Me COOEt OMe OMe CH927 Q.sub.11 Me COOEt Me OMe N928 Q.sub.11 H CN Me OMe CH929 Q.sub.11 H CN OMe OMe CH930 Q.sub.11 H CN Me OMe N931 Q.sub.11 H H Me OMe CH932 Q.sub.11 H H OMe OMe CH933 Q.sub.11 H H Me OMe N934 Me H Q.sub.11 Me Me CH935 Me H Q.sub.11 Me OMe CH936 Me H Q.sub.11 OMe OMe CH937 Me H Q.sub.11 Me OMe N938 Me H Q.sub.11 OMe OMe N939 Q.sub.12 H COOMe Me Me CH940 Q.sub.12 H COOMe Me OMe CH941 Q.sub.12 H COOMe OMe OMe CH942 Q.sub.12 H COOMe Me OMe N943 Q.sub.12 H COOMe OMe OMe N944 Q.sub.12 H COOEt Me Me CH945 Q.sub.12 H COOEt Me OMe CH946 Q.sub.12 H COOEt OMe OMe CH947 Q.sub.12 H COOEt Me OMe N948 Q.sub.12 H COOEt OMe OMe N949 Q.sub.12 Me COOMe Me OMe CH950 Q.sub.12 Me COOMe OMe OMe CH951 Q.sub.12 Me COOMe Me OMe N952 Q.sub.12 Me COOEt Me OMe CH953 Q.sub.12 Me COOEt OMe OMe CH954 Q.sub.12 Me COOEt Me OMe N955 Q.sub.12 H CN Me OMe CH956 Q.sub.12 H CN OMe OMe CH957 Q.sub.12 H CN Me OMe N958 Q.sub.12 H H Me OMe CH959 Q.sub.12 H H OMe OMe CH960 Q.sub.12 H H Me OMe N961 Me H Q.sub.12 Me Me CH962 Me H Q.sub.12 Me OMe CH963 Me H Q.sub.12 OMe OMe CH964 Me H Q.sub.12 Me OMe N965 Me H Q.sub.12 OMe OMe N966 Q.sub.13 H COOMe Me OMe CH967 Q.sub.13 H COOMe OMe OMe CH968 Q.sub.13 H COOEt Me OMe CH969 Q.sub.13 H COOEt OMe OMe CH970 Q.sub.13 Me COOMe Me OMe CH971 Q.sub.13 Me COOMe OMe OMe CH972 Q.sub.13 Me COOEt Me OMe CH973 Q.sub.13 Me COOEt OMe OMe CH974 Q.sub.13 H H Me OMe CH975 Q.sub.13 H H OMe OMe CH976 Me H Q.sub.13 Me OMe CH977 Me H Q.sub.13 OMe OMe CH978 Q.sub.14 H COOMe Me Me CH979 Q.sub.14 H COOMe Me OMe CH980 Q.sub.14 H COOMe OMe OMe CH981 Q.sub.14 H COOMe Me OMe N982 Q.sub.14 H COOMe OMe OMe N983 Q.sub.14 H COOEt Me Me CH984 Q.sub.14 H COOEt Me OMe CH985 Q.sub.14 H COOEt OMe OMe CH986 Q.sub.14 H COOEt Me OMe N987 Q.sub.14 H COOEt OMe OMe N988 Q.sub.14 Me COOMe Me OMe CH989 Q.sub.14 Me COOMe OMe OMe CH990 Q.sub.14 Me COOMe Me OMe N991 Q.sub.14 Me COOEt Me OMe CH992 Q.sub.14 Me COOEt OMe OMe CH993 Q.sub.14 Me COOEt Me OMe N994 Q.sub.14 H CN Me OMe CH995 Q.sub.14 H CN OMe OMe CH996 Q.sub.14 H CN Me OMe N997 Q.sub.14 H H Me OMe CH998 Q.sub.14 H H OMe OMe CH999 Q.sub.14 H H Me OMe N1000 Me H Q.sub.14 Me Me CH1001 Me H Q.sub.14 Me OMe CH1002 Me H Q.sub.14 OMe OMe CH1003 Me H Q.sub.14 Me OMe N1004 Me H Q.sub.14 OMe OMe N1005 Q.sub.15 H COOMe Me Me CH1006 Q.sub.15 H COOMe Me OMe CH1007 Q.sub.15 H COOMe OMe OMe CH1008 Q.sub.15 H COOMe Me OMe N1009 Q.sub.15 H COOMe OMe OMe N1010 Q.sub.15 H COOEt Me Me CH1011 Q.sub.15 H COOEt Me OMe CH1012 Q.sub.15 H COOEt OMe OMe CH1013 Q.sub.15 H COOEt Me OMe N1014 Q.sub.15 H COOEt OMe OMe N1015 Q.sub.15 Me COOMe Me OMe CH1016 Q.sub.15 Me COOMe OMe OMe CH1017 Q.sub.15 Me COOMe Me OMe N1018 Q.sub.15 Me COOEt Me OMe CH1019 Q.sub.15 Me COOEt OMe OMe CH1020 Q.sub.15 Me COOEt Me OMe N1021 Q.sub.15 H CN Me OMe CH1022 Q.sub.15 H CN OMe OMe CH1023 Q.sub.15 H CN Me OMe N1024 Q.sub.15 H H Me OMe CH1025 Q.sub.15 H H OMe OMe CH1026 Q.sub.15 H H Me OMe N1027 Me H Q.sub.15 Me Me CH1028 Me H Q.sub.15 Me OMe CH1029 Me H Q.sub.15 OMe OMe CH1030 Me H Q.sub.15 Me OMe N1031 Me H Q.sub.15 OMe OMe N1032 Q.sub.16 H COOMe Me Me CH1033 Q.sub.16 H COOMe Me OMe CH1034 Q.sub.16 H COOMe OMe OMe CH1035 Q.sub.16 H COOMe Me OMe N1036 Q.sub.16 H COOMe OMe OMe N1037 Q.sub.16 H COOEt Me Me CH1038 Q.sub.16 H COOEt Me OMe CH1039 Q.sub.16 H COOEt OMe OMe CH1040 Q.sub.16 H COOEt Me OMe N1041 Q.sub.16 H COOEt OMe OMe N1042 Q.sub.16 Me COOMe Me OMe CH1043 Q.sub.16 Me COOMe OMe OMe CH1044 Q.sub.16 Me COOMe Me OMe N1045 Q.sub.16 Me COOEt Me OMe CH1046 Q.sub.16 Me COOEt OMe OMe CH1047 Q.sub.16 Me COOEt Me OMe N1048 Q.sub.16 H CN Me OMe CH1049 Q.sub.16 H CN OMe OMe CH1050 Q.sub.16 H CN Me OMe N1051 Q.sub.16 H H Me OMe CH1052 Q.sub.16 H H OMe OMe CH1053 Q.sub.16 H H Me OMe N1054 Me H Q.sub.16 Me Me CH1055 Me H Q.sub.16 Me OMe CH1056 Me H Q.sub.16 OMe OMe CH1057 Me H Q.sub.16 Me OMe N1058 Me H Q.sub.16 OMe OMe N1059 Q.sub.17 H COOMe Me OMe CH1060 Q.sub.17 H COOMe OMe OMe CH1061 Q.sub.17 H COOEt Me OMe CH1062 Q.sub.17 H COOEt OMe OMe CH1063 Q.sub.17 Me COOMe Me OMe CH1064 Q.sub.17 Me COOMe OMe OMe CH1065 Q.sub.17 Me COOEt Me OMe CH1066 Q.sub.17 Me COOEt OMe OMe CH1067 Q.sub.17 H H Me OMe CH1068 Q.sub.17 H H OMe OMe CH1069 Me H Q.sub.17 Me OMe CH1070 Me H Q.sub.17 OMe OMe CH1071 Q.sub.18 H COOMe Me Me CH1072 Q.sub.18 H COOMe Me OMe CH1073 Q.sub.18 H COOMe OMe OMe CH1074 Q.sub.18 H COOMe Me OMe N1075 Q.sub.18 H COOMe OMe OMe N1076 Q.sub.18 H COOEt Me Me CH1077 Q.sub.18 H COOEt Me OMe CH1078 Q.sub.18 H COOEt OMe OMe CH1079 Q.sub.18 H COOEt Me OMe N1080 Q.sub.18 H COOEt OMe OMe N1081 Q.sub.18 Me COOMe Me OMe CH1082 Q.sub.18 Me COOMe OMe OMe CH1083 Q.sub.18 Me COOMe Me OMe N1084 Q.sub.18 Me COOEt Me OMe CH1085 Q.sub.18 Me COOEt OMe OMe CH1086 Q.sub.18 Me COOEt Me OMe N1087 Q.sub.18 H CN Me OMe CH1088 Q.sub.18 H CN OMe OMe CH1089 Q.sub.18 H CN Me OMe N1090 Q.sub.18 H H Me OMe CH1091 Q.sub.18 H H OMe OMe CH1092 Q.sub.18 H H Me OMe N1093 Me H Q.sub.18 Me Me CH1094 Me H Q.sub.18 Me OMe CH1095 Me H Q.sub.18 OMe OMe CH1096 Me H Q.sub.18 Me OMe N1097 Me H Q.sub.18 OMe OMe N1098 Q.sub.19 H COOMe Me Me CH1099 Q.sub.19 H COOMe Me OMe CH1100 Q.sub.19 H COOMe OMe OMe CH1101 Q.sub.19 H COOMe Me OMe N1102 Q.sub.19 H COOMe OMe OMe N1103 Q.sub.19 H COOEt Me Me CH1104 Q.sub.19 H COOEt Me OMe CH1105 Q.sub.19 H COOEt OMe OMe CH1106 Q.sub.19 H COOEt Me OMe N1107 Q.sub.19 H COOEt OMe OMe N1108 Q.sub.19 Me COOMe Me OMe CH1109 Q.sub.19 Me COOMe OMe OMe CH1110 Q.sub.19 Me COOMe Me OMe N1111 Q.sub.19 Me COOEt Me OMe CH1112 Q.sub.19 Me COOEt OMe OMe CH1113 Q.sub.19 Me COOEt Me OMe N1114 Q.sub.19 H CN Me OMe CH1115 Q.sub.19 H CN OMe OMe CH1116 Q.sub.19 H CN Me OMe N1117 Q.sub.19 H H Me OMe CH1118 Q.sub.19 H H OMe OMe CH1119 Q.sub.19 H H Me OMe N1120 Me H Q.sub.19 Me Me CH1121 Me H Q.sub.19 Me OMe CH1122 Me H Q.sub.19 OMe OMe CH1123 Me H Q.sub.19 Me OMe N1124 Me H Q.sub.19 OMe OMe N1125 Q.sub.20 H COOMe Me Me CH1126 Q.sub.20 H COOMe Me OMe CH1127 Q.sub.20 H COOMe OMe OMe CH1128 Q.sub.20 H COOMe Me OMe N1129 Q.sub.20 H COOMe OMe OMe N1130 Q.sub.20 H COOEt Me Me CH1131 Q.sub.20 H COOEt Me OMe CH1132 Q.sub.20 H COOEt OMe OMe CH1133 Q.sub.20 H COOEt Me OMe N1134 Q.sub.20 H COOEt OMe OMe N1135 Q.sub.20 Me COOMe Me OMe CH1136 Q.sub.20 Me COOMe OMe OMe CH1137 Q.sub.20 Me COOMe Me OMe N1138 Q.sub.20 Me COOEt Me OMe CH1139 Q.sub.20 Me COOEt OMe OMe CH1140 Q.sub.20 Me COOEt Me OMe N1141 Q.sub.20 H CN Me OMe CH1142 Q.sub.20 H CN OMe OMe CH1143 Q.sub.20 H CN Me OMe N1144 Q.sub.20 H H Me OMe CH1145 Q.sub.20 H H OMe OMe CH1146 Q.sub.20 H H Me OMe N1147 Me H Q.sub.20 Me Me CH1148 Me H Q.sub.20 Me OMe CH1149 Me H Q.sub.20 OMe OMe CH1150 Me H Q.sub.20 Me OMe N1151 Me H Q.sub.20 OMe OMe N1152 Q.sub.21 H COOMe Me Me CH1153 Q.sub.21 H COOMe Me OMe CH1154 Q.sub.21 H COOMe OMe OMe CH1155 Q.sub.21 H COOMe Me OMe N1156 Q.sub.21 H COOMe OMe OMe N1157 Q.sub.21 H COOEt Me Me CH1158 Q.sub.21 H COOEt Me OMe CH1159 Q.sub.21 H COOEt OMe OMe CH1160 Q.sub.21 H COOEt Me OMe N1161 Q.sub.21 H COOEt OMe OMe N1162 Q.sub.21 Me COOMe Me OMe CH1163 Q.sub.21 Me COOMe OMe OMe CH1164 Q.sub.21 Me COOMe Me OMe N1165 Q.sub.21 Me COOEt Me OMe CH1166 Q.sub.21 Me COOEt OMe OMe CH1167 Q.sub.21 Me COOEt Me OMe N1168 Q.sub.21 H CN Me OMe CH1169 Q.sub.21 H CN OMe OMe CH1170 Q.sub.21 H CN Me OMe N1171 Q.sub.21 H H Me OMe CH1172 Q.sub.21 H H OMe OMe CH1173 Q.sub.21 H H Me OMe N1174 Me H Q.sub.21 Me Me CH1175 Me H Q.sub.21 Me OMe CH1176 Me H Q.sub.21 OMe OMe CH1177 Me H Q.sub.21 Me OMe N1178 Me H Q.sub.21 OMe OMe N1179 Q.sub.22 H COOMe Me Me CH1180 Q.sub.22 H COOMe Me OMe CH1181 Q.sub.22 H COOMe OMe OMe CH1182 Q.sub.22 H COOMe Me OMe N1183 Q.sub.22 H COOMe OMe OMe N1184 Q.sub.22 H COOEt Me Me CH1185 Q.sub.22 H COOEt Me OMe CH1186 Q.sub.22 H COOEt OMe OMe CH1187 Q.sub.22 H COOEt Me OMe N1188 Q.sub.22 H COOEt OMe OMe N1189 Q.sub.22 Me COOMe Me OMe CH1190 Q.sub.22 Me COOMe OMe OMe CH1191 Q.sub.22 Me COOMe Me OMe N1192 Q.sub.22 Me COOEt Me OMe CH1193 Q.sub.22 Me COOEt OMe OMe CH1194 Q.sub.22 Me COOEt Me OMe N1195 Q.sub.22 H CN Me OMe CH1196 Q.sub.22 H CN OMe OMe CH1197 Q.sub.22 H CN Me OMe N1198 Q.sub.22 H H Me OMe CH1199 Q.sub.22 H H OMe OMe CH1200 Q.sub.22 H H Me OMe N1201 Me H Q.sub.22 Me Me CH1202 Me H Q.sub.22 Me OMe CH1203 Me H Q.sub.22 OMe OMe CH1204 Me H Q.sub.22 Me OMe N1205 Me H Q.sub.22 OMe OMe N1206 Q.sub.23 H COOMe Me OMe CH1207 Q.sub.23 H COOMe OMe OMe CH1208 Q.sub.23 H COOEt Me OMe CH1209 Q.sub.23 H COOEt OMe OMe CH1210 Q.sub.23 Me COOMe Me OMe CH1211 Q.sub.23 Me COOMe OMe OMe CH1212 Q.sub.23 Me COOEt Me OMe CH1213 Q.sub.23 Me COOEt OMe OMe CH1214 Q.sub.23 H H Me OMe CH1215 Q.sub.23 H H OMe OMe CH1216 Me H Q.sub.23 Me OMe CH1217 Me H Q.sub.23 OMe OMe CH1218 Q.sub.24 H COOMe Me Me CH1219 Q.sub.24 H COOMe Me OMe CH1220 Q.sub.24 H COOMe OMe OMe CH1221 Q.sub.24 H COOMe Me OMe N1222 Q.sub.24 H COOMe OMe OMe N1223 Q.sub.24 H COOEt Me Me CH1224 Q.sub.24 H COOEt Me OMe CH1225 Q.sub.24 H COOEt OMe OMe CH1226 Q.sub.24 H COOEt Me OMe N1227 Q.sub.24 H COOEt OMe OMe N1228 Q.sub.24 Me COOMe Me OMe CH1229 Q.sub.24 Me COOMe OMe OMe CH1230 Q.sub.24 Me COOMe Me OMe N1231 Q.sub.24 Me COOEt Me OMe CH1232 Q.sub.24 Me COOEt OMe OMe CH1233 Q.sub.24 Me COOEt Me OMe N1234 Q.sub.24 H CN Me OMe CH1235 Q.sub.24 H CN OMe OMe CH1236 Q.sub.24 H CN Me OMe N1237 Q.sub.24 H H Me OMe CH1238 Q.sub.24 H H OMe OMe CH1239 Q.sub.24 H H Me OMe N1240 Me H Q.sub.24 Me Me CH1241 Me H Q.sub.24 Me OMe CH1242 Me H Q.sub.24 OMe OMe CH1243 Me H Q.sub.24 Me OMe N1244 Me H Q.sub.24 OMe OMe N1245 Q.sub.25 H COOMe Me Me CH1246 Q.sub.25 H COOMe Me OMe CH1247 Q.sub.25 H COOMe OMe OMe CH1248 Q.sub.25 H COOMe Me OMe N1249 Q.sub.25 H COOMe OMe OMe N1250 Q.sub.25 H COOEt Me Me CH1251 Q.sub.25 H COOEt Me OMe CH1252 Q.sub.25 H COOEt OMe OMe CH1253 Q.sub.25 H COOEt Me OMe N1254 Q.sub.25 H COOEt OMe OMe N1255 Q.sub.25 Me COOMe Me OMe CH1256 Q.sub.25 Me COOMe OMe OMe CH1257 Q.sub.25 Me COOMe Me OMe N1258 Q.sub.25 Me COOEt Me OMe CH1259 Q.sub.25 Me COOEt OMe OMe CH1260 Q.sub.25 Me COOEt Me OMe N1261 Q.sub.25 H CN Me OMe CH1262 Q.sub.25 H CN OMe OMe CH1263 Q.sub.25 H CN Me OMe N1264 Q.sub.25 H H Me OMe CH1265 Q.sub.25 H H OMe OMe CH1266 Q.sub.25 H H Me OMe N1267 Me H Q.sub.25 Me Me CH1268 Me H Q.sub.25 Me OMe CH1269 Me H Q.sub.25 OMe OMe CH1270 Me H Q.sub.25 Me OMe N1271 Me H Q.sub.25 OMe OMe N1272 Q.sub.26 H COOMe Me OMe CH1273 Q.sub.26 H COOMe OMe OMe CH1274 Q.sub.26 H COOEt Me OMe CH1275 Q.sub.26 H COOEt OMe OMe CH1276 Q.sub.26 Me COOMe Me OMe CH1277 Q.sub.26 Me COOMe OMe OMe CH1278 Q.sub.26 Me COOEt Me OMe CH1279 Q.sub.26 Me COOEt OMe OMe CH1280 Q.sub.26 H H Me OMe CH1281 Q.sub.26 H H OMe OMe CH1282 Me H Q.sub.26 Me OMe CH1283 Me H Q.sub.26 OMe OMe CH1284 Q.sub.27 H COOMe Me OMe CH1285 Q.sub.27 H COOMe OMe OMe CH1286 Q.sub.27 H COOEt Me OMe CH1287 Q.sub.27 H COOEt OMe OMe CH1288 Q.sub.27 Me COOMe Me OMe CH1289 Q.sub.27 Me COOMe OMe OMe CH1290 Q.sub.27 Me COOEt Me OMe CH1291 Q.sub.27 Me COOEt OMe OMe CH1292 Q.sub.27 H H Me OMe CH1293 Q.sub.27 H H OMe OMe CH1294 Me H Q.sub.27 Me OMe CH1295 Me H Q.sub.27 OMe OMe CH1296 Q.sub.28 H COOMe Me Me CH1297 Q.sub.28 H COOMe Me OMe CH1298 Q.sub.28 H COOMe OMe OMe CH1299 Q.sub.28 H COOMe Me OMe N1300 Q.sub.28 H COOMe OMe OMe N1301 Q.sub.28 H COOEt Me Me CH1302 Q.sub.28 H COOEt Me OMe CH1303 Q.sub.28 H COOEt OMe OMe CH1304 Q.sub.28 H COOEt Me OMe N1305 Q.sub.28 H COOEt OMe OMe N1306 Q.sub.28 Me COOMe Me OMe CH1307 Q.sub.28 Me COOMe OMe OMe CH1308 Q.sub.28 Me COOMe Me OMe N1309 Q.sub.28 Me COOEt Me OMe CH1310 Q.sub.28 Me COOEt OMe OMe CH1311 Q.sub.28 Me COOEt Me OMe N1312 Q.sub.28 H CN Me OMe CH1313 Q.sub.28 H CN OMe OMe CH1314 Q.sub.28 H CN Me OMe N1315 Q.sub.28 H H Me OMe CH1316 Q.sub.28 H H OMe OMe CH1317 Q.sub.28 H H Me OMe N1318 Me H Q.sub.28 Me Me CH1319 Me H Q.sub.28 Me OMe CH1320 Me H Q.sub.28 OMe OMe CH1321 Me H Q.sub.28 Me OMe N1322 Me H Q.sub.28 OMe OMe N1323 Q.sub.29 H COOMe Me OMe CH1324 Q.sub.29 H COOMe OMe OMe CH1325 Q.sub.29 H COOEt Me OMe CH1326 Q.sub.29 H COOEt OMe OMe CH1327 Q.sub.29 Me COOMe Me OMe CH1328 Q.sub.29 Me COOMe OMe OMe CH1329 Q.sub.29 Me COOEt Me OMe CH1330 Q.sub.29 Me COOEt OMe OMe CH1331 Q.sub.29 H H Me OMe CH1332 Q.sub.29 H H OMe OMe CH1333 Me H Q.sub.29 Me OMe CH1334 Me H Q.sub.29 OMe OMe CH1335 Q.sub.30 H COOMe Me OMe CH1336 Q.sub.30 H COOMe OMe OMe CH1337 Q.sub.30 H COOEt Me OMe CH1338 Q.sub.30 H COOEt OMe OMe CH1339 Q.sub.30 Me COOMe Me OMe CH1340 Q.sub.30 Me COOMe OMe OMe CH1341 Q.sub.30 Me COOEt Me OMe CH1342 Q.sub.30 Me COOEt OMe OMe CH1343 Q.sub.30 H H Me OMe CH1344 Q.sub.30 H H OMe OMe CH1345 Me H Q.sub.30 Me OMe CH1346 Me H Q.sub.30 OMe OMe CH1347 Q.sub.31 H COOMe Me OMe CH1348 Q.sub.31 H COOMe OMe OMe CH1349 Q.sub.31 H COOEt Me OMe CH1350 Q.sub.31 H COOEt OMe OMe CH1351 Q.sub.31 Me COOMe Me OMe CH1352 Q.sub.31 Me COOMe OMe OMe CH1353 Q.sub.31 Me COOEt Me OMe CH1354 Q.sub.31 Me COOEt OMe OMe CH1355 Q.sub.31 H H Me OMe CH1356 Q.sub.31 H H OMe OMe CH1357 Me H Q.sub.31 Me OMe CH1358 Me H Q.sub.31 OMe OMe CH1359 Q.sub.32 H COOMe Me Me CH1360 Q.sub.32 H COOMe Me OMe CH1361 Q.sub.32 H COOMe OMe OMe CH1362 Q.sub.32 H COOMe Me Me N1363 Q.sub.32 H COOMe Me OMe N1364 Q.sub.32 H COOMe OMe OMe N1365 Q.sub.32 H COOMe Me OCHF.sub.2 CH1366 Q.sub.32 H COOMe Cl OMe CH1367 Q.sub.32 H COOEt Me Me CH1368 Q.sub.32 H COOEt Me OMe CH1369 Q.sub.32 H COOEt OMe OMe CH1370 Q.sub.32 H COOEt Me Me N1371 Q.sub.32 H COOEt Me OMe N1372 Q.sub.32 H COOEt OMe OMe N1373 Q.sub.32 H COOEt Me OCHF.sub.2 CH1374 Q.sub.32 H COOEt Cl OMe CH1375 Q.sub.32 H COOPrn Me OMe CH1376 Q.sub.32 H COOPrn OMe OMe CH1377 Q.sub.32 H COOPrn Me OMe N1378 Q.sub.32 H COOPri Me OMe CH1379 Q.sub.32 H COOPri OMe OMe CH1380 Q.sub.32 H COOPri Me OMe N1381 Q.sub.32 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH1382 Q.sub.32 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH1383 Q.sub.32 H COOCH.sub.2 CH.sub.2 Cl Me OMe N1384 Q.sub. 32 H COOCH.sub.2 CHCH.sub.2 Me OMe CH1385 Q.sub.32 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH1386 Q.sub.32 H COOCH.sub.2 CHCH.sub.2 Me OMe N1387 Q.sub.32 H COOCH.sub.2 CCH Me OMe CH1388 Q.sub.32 H COOCH.sub.2 CCH OMe OMe CH1389 Q.sub.32 H COOCH.sub.2 CCH Me OMe N1390 Q.sub.32 Me COOMe Me Me CH1391 Q.sub.32 Me COOMe Me OMe CH1392 Q.sub.32 Me COOMe OMe OMe CH1393 Q.sub.32 Me COOMe Me OMe N1394 Q.sub.32 Me COOMe OMe OMe N1395 Q.sub.32 Me COOEt Me Me CH1396 Q.sub.32 Me COOEt Me OMe CH1397 Q.sub.32 Me COOEt OMe OMe CH1398 Q.sub.32 Me COOEt Me OMe N1399 Q.sub.32 Me COOEt OMe OMe N1400 Q.sub.32 Cl COOMe Me OMe CH1401 Q.sub.32 Cl COOMe OMe OMe CH1402 Q.sub.32 Cl COOMe Me OMe N1403 Q.sub. 32 Cl COOEt Me OMe CH1404 Q.sub.32 Cl COOEt OMe OMe CH1405 Q.sub.32 Cl COOEt Me OMe N1406 Q.sub.32 OMe COOMe Me OMe CH1407 Q.sub.32 OMe COOMe OMe OMe CH1408 Q.sub.32 OMe COOMe Me OMe N1409 Q.sub.32 OMe COOEt Me OMe CH1410 Q.sub.32 OMe COOEt OMe OMe CH1411 Q.sub.32 OMe COOEt Me OMe N1412 Q.sub.32 H Cl Me OMe CH1413 Q.sub.32 H Cl OMe OMe CH1414 Q.sub.32 H Cl Me OMe N1415 Q.sub.32 H NO.sub.2 Me OMe CH1416 Q.sub.32 H NO.sub.2 OMe OMe CH1417 Q.sub.32 H NO.sub.2 Me OMe N1418 Q.sub.32 H SO.sub.2 NMe.sub.2 Me OMe CH1419 Q.sub.32 H SO.sub.2 NMe.sub.2 OMe OMe CH1420 Q.sub.32 H SO.sub.2 NMe.sub.2 Me OMe N1421 Q.sub.32 H CN Me OMe CH1422 Q.sub.32 H CN OMe OMe CH1423 Q.sub.32 H CN Me OMe N1424 Q.sub.32 Me CN Me OMe CH1425 Q.sub.32 Me CN OMe OMe CH1426 Q.sub.32 Me CN Me OMe N1427 Q.sub.32 H Me Me OMe CH1428 Q.sub.32 H Me OMe OMe CH1429 Q.sub.32 H Me Me OMe N1430 Q.sub.32 H Et Me OMe CH1431 Q.sub.32 H Et OMe OMe CH1432 Q.sub.32 H Et Me OMe N1433 Q.sub.32 H H Me OMe CH1434 Q.sub.32 H H OMe OMe CH1435 Q.sub.32 H H Me OMe N1436 Q.sub.32 H COPh Me OMe CH1437 Q.sub.32 H COPh OMe OMe CH1438 Q.sub.32 H COPh Me OMe N1439 Me Q.sub.32 COOMe Me OMe CH1440 Me Q.sub.32 COOMe OMe OMe CH1441 Me Q.sub.32 COOMe Me OMe N1442 H H Q.sub.32 Me OMe CH1443 H H Q.sub.32 OMe OMe CH1444 H H Q.sub.32 Me OMe N1445 Me H Q.sub.32 Me Me CH1446 Me H Q.sub.32 Me OMe CH1447 Me H Q.sub.32 OMe OMe CH1448 Me H Q.sub.32 Me OMe N1449 Me H Q.sub.32 OMe OMe N1450 Me Me Q.sub.32 Me OMe CH1451 Me Me Q.sub.32 OMe OMe CH1452 Me Me Q.sub.32 Me OMe N1453 Q.sub.33 H COOMe Me Me CH1454 Q.sub.33 H COOMe Me OMe CH1455 Q.sub.33 H COOMe OMe OMe CH1456 Q.sub.33 H COOMe Me OMe N1457 Q.sub.33 H COOMe OMe OMe N1458 Q.sub.33 H COOEt Me Me CH1459 Q.sub.33 H COOEt Me OMe CH1460 Q.sub.33 H COOEt OMe OMe CH1461 Q.sub.33 H COOEt Me OMe N1462 Q.sub.33 H COOEt OMe OMe N1463 Q.sub.33 Me COOMe Me OMe CH1464 Q.sub.33 Me COOMe OMe OMe CH1465 Q.sub.33 Me COOMe Me OMe N1466 Q.sub.33 Me COOEt Me OMe CH1467 Q.sub.33 Me COOEt OMe OMe CH1468 Q.sub.33 Me COOEt Me OMe N1469 Q.sub.33 H CN Me OMe CH1470 Q.sub.33 H CN OMe OMe CH1471 Q.sub.33 H CN Me OMe N1472 Q.sub.33 H H Me OMe CH1473 Q.sub.33 H H OMe OMe CH1474 Q.sub.33 H H Me OMe N1475 Me H Q.sub.33 Me Me CH1476 Me H Q.sub.33 Me OMe CH1477 Me H Q.sub.33 OMe OMe CH1478 Me H Q.sub.33 Me OMe N1479 Me H Q.sub.33 OMe OMe N1480 Q.sub.34 H COOMe Me Me CH1481 Q.sub.34 H COOMe Me OMe CH1482 Q.sub.34 H COOMe OMe OMe CH1483 Q.sub.34 H COOMe Me OMe N1484 Q.sub.34 H COOMe OMe OMe N1485 Q.sub.34 H COOEt Me Me CH1486 Q.sub.34 H COOEt Me OMe CH1487 Q.sub.34 H COOEt OMe OMe CH1488 Q.sub.34 H COOEt Me OMe N1489 Q.sub.34 H COOEt OMe OMe N1490 Q.sub.34 Me COOMe Me OMe CH1491 Q.sub.34 Me COOMe OMe OMe CH1492 Q.sub.34 Me COOMe Me OMe N1493 Q.sub.34 Me COOEt Me OMe CH1494 Q.sub.34 Me COOEt OMe OMe CH1495 Q.sub.34 Me COOEt Me OMe N1496 Q.sub.34 H CN Me OMe CH1497 Q.sub.34 H CN OMe OMe CH1498 Q.sub.34 H CN Me OMe N1499 Q.sub.34 H H Me OMe CH1500 Q.sub.34 H H OMe OMe CH1501 Q.sub.34 H H Me OMe N1502 Me H Q.sub.34 Me Me CH1503 Me H Q.sub.34 Me OMe CH1504 Me H Q.sub.34 OMe OMe CH1505 Me H Q.sub.34 Me OMe N1506 Me H Q.sub.34 OMe OMe N1507 Q.sub.35 H COOMe Me Me CH1508 Q.sub.35 H COOMe Me OMe CH1509 Q.sub.35 H COOMe OMe OMe CH1510 Q.sub.35 H COOMe Me OMe N1511 Q.sub.35 H COOMe OMe OMe N1512 Q.sub.35 H COOEt Me Me CH1513 Q.sub.35 H COOEt Me OMe CH1514 Q.sub.35 H COOEt OMe OMe CH1515 Q.sub.35 H COOEt Me OMe N1516 Q.sub.35 H COOEt OMe OMe N1517 Q.sub.35 Me COOMe Me OMe CH1518 Q.sub.35 Me COOMe OMe OMe CH1519 Q.sub.35 Me COOMe Me OMe N1520 Q.sub.35 Me COOEt Me OMe CH1521 Q.sub.35 Me COOEt OMe OMe CH1522 Q.sub.35 Me COOEt Me OMe N1523 Q.sub.35 H CN Me OMe CH1524 Q.sub.35 H CN OMe OMe CH1525 Q.sub.35 H CN Me OMe N1526 Q.sub.35 H H Me OMe CH1527 Q.sub.35 H H OMe OMe CH1528 Q.sub.35 H H Me OMe N1529 Me H Q.sub.35 Me Me CH1530 Me H Q.sub.35 Me OMe CH1531 Me H Q.sub.35 OMe OMe CH1532 Me H Q.sub.35 Me OMe N1533 Me H Q.sub.35 OMe OMe N1534 Q.sub.36 H COOMe Me OMe CH1535 Q.sub.36 H COOMe OMe OMe CH1536 Q.sub.36 H COOEt Me OMe CH1537 Q.sub.36 H COOEt OMe OMe CH1538 Q.sub.36 Me COOMe Me OMe CH1539 Q.sub.36 Me COOMe OMe OMe CH1540 Q.sub.36 Me COOEt Me OMe CH1541 Q.sub.36 Me COOEt OMe OMe CH1542 Q.sub.36 H H Me OMe CH1543 Q.sub.36 H H OMe OMe CH1544 Me H Q.sub.36 Me OMe CH1545 Me H Q.sub.36 OMe OMe CH1546 Q.sub.37 H COOMe Me Me CH1547 Q.sub.37 H COOMe Me OMe CH1548 Q.sub.37 H COOMe OMe OMe CH1549 Q.sub.37 H COOMe Me OMe N1550 Q.sub.37 H COOMe OMe OMe N1551 Q.sub.37 H COOEt Me Me CH1552 Q.sub.37 H COOEt Me OMe CH1553 Q.sub.37 H COOEt OMe OMe CH1554 Q.sub.37 H COOEt Me OMe N1555 Q.sub.37 H COOEt OMe OMe N1556 Q.sub.37 Me COOMe Me OMe CH1557 Q.sub.37 Me COOMe OMe OMe CH1558 Q.sub.37 Me COOMe Me OMe N1559 Q.sub.37 Me COOEt Me OMe CH1560 Q.sub.37 Me COOEt OMe OMe CH1561 Q.sub.37 Me COOEt Me OMe N1562 Q.sub.37 H CN Me OMe CH1563 Q.sub.37 H CN OMe OMe CH1564 Q.sub.37 H CN Me OMe N1565 Q.sub.37 H H Me OMe CH1566 Q.sub.37 H H OMe OMe CH1567 Q.sub.37 H H Me OMe N1568 Me H Q.sub.37 Me Me CH1569 Me H Q.sub.37 Me OMe CH1570 Me H Q.sub.37 OMe OMe CH1571 Me H Q.sub.37 Me OMe N1572 Me H Q.sub.37 OMe OMe N1573 Q.sub.38 H COOMe Me Me CH1574 Q.sub.38 H COOMe Me OMe CH1575 Q.sub.38 H COOMe OMe OMe CH1576 Q.sub.38 H COOMe Me OMe N1577 Q.sub.38 H COOMe OMe OMe N1578 Q.sub.38 H COOEt Me Me CH1579 Q.sub.38 H COOEt Me OMe CH1580 Q.sub.38 H COOEt OMe OMe CH1581 Q.sub.38 H COOEt Me OMe N1582 Q.sub.38 H COOEt OMe OMe N1583 Q.sub.38 Me COOMe Me OMe CH1584 Q.sub.38 Me COOMe OMe OMe CH1585 Q.sub.38 Me COOMe Me OMe N1586 Q.sub.38 Me COOEt Me OMe CH1587 Q.sub.38 Me COOEt OMe OMe CH1588 Q.sub.38 Me COOEt Me OMe N1589 Q.sub.38 H CN Me OMe CH1590 Q.sub.38 H CN OMe OMe CH1591 Q.sub.38 H CN Me OMe N1592 Q.sub.38 H H Me OMe CH1593 Q.sub.38 H H OMe OMe CH1594 Q.sub.38 H H Me OMe N1595 Me H Q.sub.38 Me Me CH1596 Me H Q.sub.38 Me OMe CH1597 Me H Q.sub.38 OMe OMe CH1598 Me H Q.sub.38 Me OMe N1599 Me H Q.sub.38 OMe OMe N1600 Q.sub.39 H COOMe Me Me CH1601 Q.sub.39 H COOMe Me OMe CH1602 Q.sub.39 H COOMe OMe OMe CH1603 Q.sub.39 H COOMe Me OMe N1604 Q.sub.39 H COOMe OMe OMe N1605 Q.sub.39 H COOEt Me Me CH1606 Q.sub.39 H COOEt Me OMe CH1607 Q.sub.39 H COOEt OMe OMe CH1608 Q.sub.39 H COOEt Me OMe N1609 Q.sub.39 H COOEt OMe OMe N1610 Q.sub.39 Me COOMe Me OMe CH1611 Q.sub.39 Me COOMe OMe OMe CH1612 Q.sub.39 Me COOMe Me OMe N1613 Q.sub.39 Me COOEt Me OMe CH1614 Q.sub.39 Me COOEt OMe OMe CH1615 Q.sub.39 Me COOEt Me OMe N1616 Q.sub.39 H CN Me OMe CH1617 Q.sub.39 H CN OMe OMe CH1618 Q.sub.39 H CN Me OMe N1619 Q.sub.39 H H Me OMe CH1620 Q.sub.39 H H OMe OMe CH1621 Q.sub.39 H H Me OMe N1622 Me H Q.sub.39 Me Me CH1623 Me H Q.sub.39 Me OMe CH1624 Me H Q.sub.39 OMe OMe CH1625 Me H Q.sub.39 Me OMe N1626 Me H Q.sub.39 OMe OMe N1627 Q.sub.40 H COOMe Me OMe CH1628 Q.sub.40 H COOMe OMe OMe CH1629 Q.sub.40 H COOEt Me OMe CH1630 Q.sub.40 H COOEt OMe OMe CH1631 Q.sub.40 Me COOMe Me OMe CH1632 Q.sub.40 Me COOMe OMe OMe CH1633 Q.sub.40 Me COOEt Me OMe CH1634 Q.sub.40 Me COOEt OMe OMe CH1635 Q.sub.40 H H Me OMe CH1636 Q.sub.40 H H OMe OMe CH1637 Me H Q.sub.40 Me OMe CH1638 Me H Q.sub.40 OMe OMe CH1639 Q.sub.41 H COOMe Me Me CH1640 Q.sub.41 H COOMe Me OMe CH1641 Q.sub.41 H COOMe OMe OMe CH1642 Q.sub.41 H COOMe Me OMe N1643 Q.sub.41 H COOMe OMe OMe N1644 Q.sub.41 H COOEt Me Me CH1645 Q.sub.41 H COOEt Me OMe CH1646 Q.sub.41 H COOEt OMe OMe CH1647 Q.sub.41 H COOEt Me OMe N1648 Q.sub.41 H COOEt OMe OMe N1649 Q.sub.41 Me COOMe Me OMe CH1650 Q.sub.41 Me COOMe OMe OMe CH1651 Q.sub.41 Me COOMe Me OMe N1652 Q.sub.41 Me COOEt Me OMe CH1653 Q.sub.41 Me COOEt OMe OMe CH1654 Q.sub.41 Me COOEt Me OMe N1655 Q.sub.41 H CN Me OMe CH1656 Q.sub.41 H CN OMe OMe CH1657 Q.sub.41 H CN Me OMe N1658 Q.sub.41 H H Me OMe CH1659 Q.sub.41 H H OMe OMe CH1660 Q.sub.41 H H Me OMe N1661 Me H Q.sub.41 Me Me CH1662 Me H Q.sub.41 Me OMe CH1663 Me H Q.sub.41 OMe OMe CH1664 Me H Q.sub.41 Me OMe N1665 Me H Q.sub.41 OMe OMe N1666 Q.sub.42 H COOMe Me Me CH1667 Q.sub.42 H COOMe Me OMe CH1668 Q.sub.42 H COOMe OMe OMe CH1669 Q.sub.42 H COOMe Me OMe N1670 Q.sub.42 H COOMe OMe OMe N1671 Q.sub.42 H COOEt Me Me CH1672 Q.sub.42 H COOEt Me OMe CH1673 Q.sub.42 H COOEt OMe OMe CH1674 Q.sub.42 H COOEt Me OMe N1675 Q.sub.42 H COOEt OMe OMe N1676 Q.sub.42 Me COOMe Me OMe CH1677 Q.sub.42 Me COOMe OMe OMe CH1678 Q.sub.42 Me COOMe Me OMe N1679 Q.sub.42 Me COOEt Me OMe CH1680 Q.sub.42 Me COOEt OMe OMe CH1681 Q.sub.42 Me COOEt Me OMe N1682 Q.sub.42 H CN Me OMe CH1683 Q.sub.42 H CN OMe OMe CH1684 Q.sub.42 H CN Me OMe N1685 Q.sub.42 H H Me OMe CH1686 Q.sub.42 H H OMe OMe CH1687 Q.sub.42 H H Me OMe N1688 Me H Q.sub.42 Me Me CH1689 Me H Q.sub.42 Me OMe CH1690 Me H Q.sub.42 OMe OMe CH1691 Me H Q.sub.42 Me OMe N1692 Me H Q.sub.42 OMe OMe N1693 Q.sub.43 H COOMe Me Me CH1694 Q.sub.43 H COOMe Me OMe CH1695 Q.sub.43 H COOMe OMe OMe CH1696 Q.sub.43 H COOMe Me OMe N1697 Q.sub.43 H COOMe OMe OMe N1698 Q.sub.43 H COOEt Me Me CH1699 Q.sub.43 H COOEt Me OMe CH1700 Q.sub.43 H COOEt OMe OMe CH1701 Q.sub.43 H COOEt Me OMe N1702 Q.sub.43 H COOEt OMe OMe N1703 Q.sub.43 Me COOMe Me OMe CH1704 Q.sub.43 Me COOMe OMe OMe CH1705 Q.sub.43 Me COOMe Me OMe N1706 Q.sub.43 Me COOEt Me OMe CH1707 Q.sub.43 Me COOEt OMe OMe CH1708 Q.sub.43 Me COOEt Me OMe N1709 Q.sub.43 H CN Me OMe CH1710 Q.sub.43 H CN OMe OMe CH1711 Q.sub.43 H CN Me OMe N1712 Q.sub.42 H H Me OMe CH1713 Q.sub.43 H H OMe OMe CH1714 Q.sub.43 H H Me OMe N1715 Me H Q.sub.43 Me Me CH1716 Me H Q.sub.43 Me OMe CH1717 Me H Q.sub.43 OMe OMe CH1718 Me H Q.sub.43 Me OMe N1719 Me H Q.sub.43 OMe OMe N1720 Q.sub.44 H COOMe Me OMe CH1721 Q.sub.44 H COOMe OMe OMe CH1722 Q.sub.44 H COOEt Me OMe CH1723 Q.sub.44 H COOEt OMe OMe CH1724 Q.sub.44 Me COOMe Me OMe CH1725 Q.sub.44 Me COOMe OMe OMe CH1726 Q.sub.44 Me COOEt Me OMe CH1727 Q.sub.44 Me COOEt OMe OMe CH1728 Q.sub.44 H H Me OMe CH1729 Q.sub.44 H H OMe OMe CH1730 Me H Q.sub.44 Me OMe CH1731 Me H Q.sub.44 OMe OMe CH1732 Q.sub.45 H COOMe Me Me CH1733 Q.sub.45 H COOMe Me OMe CH1734 Q.sub.45 H COOMe OMe OMe CH1735 Q.sub.45 H COOMe Me Me N1736 Q.sub.45 H COOMe Me OMe N1737 Q.sub.45 H COOMe OMe OMe N1738 Q.sub.45 H COOMe Me OCHF.sub.2 CH1739 Q.sub.45 H COOMe Cl OMe CH1740 Q.sub.45 H COOEt Me Me CH1741 Q.sub.45 H COOEt Me OMe CH1742 Q.sub.45 H COOEt OMe OMe CH1743 Q.sub.45 H COOEt Me Me N1744 Q.sub.45 H COOEt Me OMe N1745 Q.sub.45 H COOEt OMe OMe N1746 Q.sub.45 H COOEt Me OCHF.sub.2 CH1747 Q.sub.45 H COOEt Cl OMe CH1748 Q.sub.45 H COOPrn Me OMe CH1749 Q.sub.45 H COOPrn OMe OMe CH1750 Q.sub.45 H COOPrn Me OMe N1751 Q.sub.45 H COOPri Me OMe CH1752 Q.sub.45 H COOPri OMe OMe CH1753 Q.sub.45 H COOPri Me OMe N1754 Q.sub.45 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH1755 Q.sub.45 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH1756 Q.sub.45 H COOCH.sub.2 CH.sub.2 Cl Me OMe N1757 Q.sub.45 H COOCH.sub.2 CHCH.sub.2 Me OMe CH1758 Q.sub.45 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH1759 Q.sub.45 H COOCH.sub.2 CHCH.sub.2 Me OMe N1760 Q.sub.45 H COOCH.sub.2 CCH Me OMe CH1761 Q.sub.45 H COOCH.sub.2 CCH OMe OMe CH1762 Q.sub.45 H COOCH.sub.2 CCH Me OMe N1763 Q.sub.45 Me COOMe Me Me CH1764 Q.sub.45 Me COOMe Me OMe CH1765 Q.sub.45 Me COOMe OMe OMe CH1766 Q.sub.45 Me COOMe Me OMe N1767 Q.sub.45 Me COOMe OMe OMe N1768 Q.sub. 45 Me COOEt Me Me CH1769 Q.sub.45 Me COOEt Me OMe CH1770 Q.sub.45 Me COOEt OMe OMe CH1771 Q.sub.45 Me COOEt Me OMe N1772 Q.sub.45 Me COOEt OMe OMe N1773 Q.sub.45 Cl COOMe Me OMe CH1774 Q.sub.45 Cl COOMe OMe OMe CH1775 Q.sub.45 Cl COOMe Me OMe N__________________________________________________________________________
__________________________________________________________________________1776 Q.sub.45 Cl COOEt Me OMe CH1777 Q.sub.45 Cl COOEt OMe OMe CH1778 Q.sub.45 Cl COOEt Me OMe N1779 Q.sub.45 OMe COOMe Me OMe CH1780 Q.sub.45 OMe COOMe OMe OMe CH1781 Q.sub.45 OMe COOMe Me OMe N1782 Q.sub.45 OMe COOEt Me OMe CH1783 Q.sub.45 OMe COOEt OMe OMe CH1784 Q.sub.45 OMe COOEt Me OMe N1785 Q.sub.45 H Cl Me OMe CH1786 Q.sub.45 H Cl OMe OMe CH1787 Q.sub.45 H Cl Me OMe N1788 Q.sub.45 H NO.sub.2 Me OMe CH1789 Q.sub.45 H NO.sub.2 OMe OMe CH1790 Q.sub.45 H NO.sub.2 Me OMe N1791 Q.sub.45 H SO.sub.2 NMe.sub.2 Me OMe CH1792 Q.sub.45 H SO.sub.2 NMe.sub.2 OMe OMe CH1793 Q.sub.45 H SO.sub.2 NMe.sub.2 Me OMe N1794 Q.sub.45 H CN Me OMe CH1795 Q.sub.45 H CN OMe OMe CH1796 Q.sub.45 H CN Me OMe N1797 Q.sub.45 Me CN Me OMe CH1798 Q.sub.45 Me CN OMe OMe CH1799 Q.sub.45 Me CN Me OMe N1800 Q.sub.45 H Me Me OMe CH1801 Q.sub.45 H Me OMe OMe CH1802 Q.sub.45 H Me Me OMe N1803 Q.sub.45 H Et Me OMe CH1804 Q.sub.45 H Et OMe OMe CH1805 Q.sub.45 H Et Me OMe N1806 Q.sub.45 H H Me OMe CH1807 Q.sub.45 H H OMe OMe CH1808 Q.sub.45 H H Me OMe N1809 Q.sub.45 H COPh Me OMe CH1810 Q.sub.45 H COPh OMe OMe CH1811 Q.sub.45 H COPh Me OMe N1812 Me Q.sub.45 COOMe Me OMe CH1813 Me Q.sub.45 COOMe OMe OMe CH1814 Me Q.sub.45 COOMe Me OMe N1815 H H Q.sub.45 Me OMe CH1816 H H Q.sub.45 OMe OMe CH1817 H H Q.sub.45 Me OMe N1818 Me H Q.sub.45 Me Me CH1819 Me H Q.sub.45 Me OMe CH1820 Me H Q.sub.45 OMe OMe CH1821 Me H Q.sub.45 Me OMe N1822 Me H Q.sub.45 OMe OMe N1823 Me Me Q.sub.45 Me OMe CH1824 Me Me Q.sub.45 OMe OMe CH1825 Me Me Q.sub.45 Me OMe N1826 Q.sub.46 H COOMe Me Me CH1827 Q.sub.46 H COOMe Me OMe CH1828 Q.sub.46 H COOMe OMe OMe CH1829 Q.sub.46 H COOMe Me OMe N1830 Q.sub.46 H COOMe OMe OMe N1831 Q.sub.46 H COOEt Me Me CH1832 Q.sub.46 H COOEt Me OMe CH1833 Q.sub.46 H COOEt OMe OMe CH1834 Q.sub.46 H COOEt Me OMe N1835 Q.sub.46 H COOEt OMe OMe N1836 Q.sub.46 Me COOMe Me OMe CH1837 Q.sub.46 Me COOMe OMe OMe CH1838 Q.sub.46 Me COOMe Me OMe N1839 Q.sub.46 Me COOEt Me OMe CH1840 Q.sub.46 Me COOEt OMe OMe CH1841 Q.sub.46 Me COOEt Me OMe N1842 Q.sub.46 H CN Me OMe CH1843 Q.sub.46 H CN OMe OMe CH1844 Q.sub.46 H CN Me OMe N1845 Q.sub.46 H H Me OMe CH1846 Q.sub.46 H H OMe OMe CH1847 Q.sub.46 H H Me OMe N1848 Me H Q.sub.46 Me Me CH1849 Me H Q.sub.46 Me OMe CH1850 Me H Q.sub.46 OMe OMe CH1851 Me H Q.sub.46 Me OMe N1852 Me H Q.sub.46 OMe OMe N1853 Q.sub.47 H COOMe Me Me CH1854 Q.sub.47 H COOMe Me OMe CH1855 Q.sub.47 H COOMe OMe OMe CH1856 Q.sub.47 H COOMe Me OMe N1857 Q.sub.47 H COOMe OMe OMe N1858 Q.sub.47 H COOEt Me Me CH1859 Q.sub.47 H COOEt Me OMe CH1860 Q.sub.47 H COOEt OMe OMe CH1861 Q.sub.47 H COOEt Me OMe N1862 Q.sub.47 H COOEt OMe OMe N1863 Q.sub.47 Me COOMe Me OMe CH1864 Q.sub.47 Me COOMe OMe OMe CH1865 Q.sub.47 Me COOMe Me OMe N1866 Q.sub.47 Me COOEt Me OMe CH1867 Q.sub.47 Me COOEt OMe OMe CH1868 Q.sub.47 Me COOEt Me OMe N1869 Q.sub.47 H CN Me OMe CH1870 Q.sub.47 H CN OMe OMe CH1871 Q.sub.47 H CN Me OMe N1872 Q.sub.47 H H Me OMe CH1873 Q.sub.47 H H OMe OMe CH1874 Q.sub.47 H H Me OMe N1875 Me H Q.sub.47 Me Me CH1876 Me H Q.sub.47 Me OMe CH1877 Me H Q.sub.47 OMe OMe CH1878 Me H Q.sub.47 Me OMe N1879 Me H Q.sub.47 OMe OMe N1880 Q.sub.48 H COOMe Me Me CH1881 Q.sub.48 H COOMe Me OMe CH1882 Q.sub.48 H COOMe OMe OMe CH1883 Q.sub.48 H COOMe Me OMe N1884 Q.sub.48 H COOMe OMe OMe N1885 Q.sub.48 H COOEt Me Me CH1886 Q.sub.48 H COOEt Me OMe CH1887 Q.sub.48 H COOEt OMe OMe CH1888 Q.sub.48 H COOEt Me OMe N1889 Q.sub.48 H COOEt OMe OMe N1890 Q.sub.48 Me COOMe Me OMe CH1891 Q.sub.48 Me COOMe OMe OMe CH1892 Q.sub.48 Me COOMe Me OMe N1893 Q.sub.48 Me COOEt Me OMe CH1894 Q.sub.48 Me COOEt OMe OMe CH1895 Q.sub.48 Me COOEt Me OMe N1896 Q.sub.48 H CN Me OMe CH1897 Q.sub.48 H CN OMe OMe CH1898 Q.sub.48 H CN Me OMe N1899 Q.sub.48 H H Me OMe CH1900 Q.sub.48 H H OMe OMe CH1901 Q.sub.48 H H Me OMe N1902 Me H Q.sub.48 Me Me CH1903 Me H Q.sub.48 Me OMe CH1904 Me H Q.sub.48 OMe OMe CH1905 Me H Q.sub.48 Me OMe N1906 Me H Q.sub.48 OMe OMe N1907 Q.sub.49 H COOMe Me Me CH1908 Q.sub.49 H COOMe Me OMe CH1909 Q.sub.49 H COOMe OMe OMe CH1910 Q.sub.49 H COOMe Me OMe N1911 Q.sub.49 H COOMe OMe OMe N1912 Q.sub.49 H COOEt Me Me CH1913 Q.sub.49 H COOEt Me OMe CH1914 Q49 H COOEt OMe OMe CH1915 Q.sub.49 H COOEt Me OMe N1916 Q.sub.49 H COOEt OMe OMe N1917 Q.sub.49 Me COOMe Me OMe CH1918 Q.sub.49 Me COOMe OMe OMe CH1919 Q.sub.49 Me COOMe Me OMe N1920 Q.sub.49 Me COOEt Me OMe CH1921 Q.sub.49 Me COOEt OMe OMe CH1922 Q.sub.49 Me COOEt Me OMe N1923 Q.sub.49 H CN Me OMe CH1924 Q.sub.49 H CN OMe OMe CH1925 Q.sub.49 H CN Me OMe N1926 Q.sub.49 H H Me OMe CH1927 Q.sub.49 H H OMe OMe CH1928 Q.sub.49 H H Me OMe N1929 Me H Q.sub.49 Me Me CH1930 Me H Q.sub.49 Me OMe CH1931 Me H Q.sub.49 OMe OMe CH1932 Me H Q.sub.49 Me OMe N1933 Me H Q.sub.49 OMe OMe N1934 Q.sub.50 H COOMe Me Me CH1935 Q.sub.50 H COOMe Me OMe CH1936 Q.sub.50 H COOMe OMe OMe CH1937 Q.sub.50 H COOMe Me OMe N1938 Q.sub.50 H COOMe OMe OMe N1939 Q.sub.50 H COOEt Me Me CH1940 Q.sub.50 H COOEt Me OMe CH1941 Q.sub.50 H COOEt OMe OMe CH1942 Q.sub.50 H COOEt Me OMe N1943 Q.sub.50 H COOEt OMe OMe N1944 Q.sub.50 Me COOMe Me OMe CH1945 Q.sub.50 Me COOMe OMe OMe CH1946 Q.sub.50 Me COOMe Me OMe N1947 Q.sub.50 Me COOEt Me OMe CH1948 Q.sub.50 Me COOEt OMe OMe CH1949 Q.sub.50 Me COOEt Me OMe N1950 Q.sub.50 H CN Me OMe CH1951 Q.sub.50 H CN OMe OMe CH1952 Q.sub.50 H CN Me OMe N1953 Q.sub.50 H H Me OMe CH1954 Q.sub.50 H H OMe OMe CH1955 Q.sub.50 H H Me OMe N1956 Me H Q.sub.50 Me Me CH1957 Me H Q.sub.50 Me OMe CH1958 Me H Q.sub.50 OMe OMe CH1959 Me H Q.sub.50 Me OMe N1960 Me H Q.sub.50 OMe OMe N1961 Q.sub.51 H COOMe Me Me CH1962 Q.sub.51 H COOMe Me OMe CH1963 Q.sub.51 H COOMe OMe OMe CH1964 Q.sub.51 H COOMe Me OMe N1965 Q.sub.51 H COOMe OMe OMe N1966 Q.sub.51 H COOEt Me Me CH1967 Q.sub.51 H COOEt Me OMe CH1968 Q.sub.51 H COOEt OMe OMe CH1969 Q.sub.51 H COOEt Me OMe N1970 Q.sub.51 H COOEt OMe OMe N1971 Q.sub.51 Me COOMe Me OMe CH1972 Q.sub.51 Me COOMe OMe OMe CH1973 Q.sub.51 Me COOMe Me OMe N1974 Q.sub.51 Me COOEt Me OMe CH1975 Q.sub.51 Me COOEt OMe OMe CH1976 Q.sub.51 Me COOEt Me OMe N1977 Q.sub.51 H CN Me OMe CH1978 Q.sub.51 H CN OMe OMe CH1979 Q.sub.51 H CN Me OMe N1980 Q.sub.51 H H Me OMe CH1981 Q.sub.51 H H OMe OMe CH1982 Q.sub.51 H H Me OMe N1983 Me H Q.sub.51 Me Me CH1984 Me H Q.sub.51 Me OMe CH1985 Me H Q.sub.51 OMe OMe CH1986 Me H Q.sub.51 Me OMe N1987 Me H Q.sub.51 OMe OMe N1988 Q.sub.52 H COOMe Me OMe CH1989 Q.sub.52 H COOMe OMe OMe CH1990 Q.sub.52 H COOEt Me OMe CH1991 Q.sub.52 H COOEt OMe OMe CH1992 Q.sub.52 Me COOMe Me OMe CH1993 Q.sub.52 Me COOMe OMe OMe CH1994 Q.sub.52 Me COOEt Me OMe CH1995 Q.sub.52 Me COOEt OMe OMe CH1996 Q.sub.52 H H Me OMe CH1997 Q.sub.52 H H OMe OMe CH1998 Me H Q.sub. 52 Me OMe CH1999 Me H Q.sub.52 OMe OMe CH2000 Q.sub.53 H COOMe Me OMe CH2001 Q.sub.53 H COOMe OMe OMe CH2002 Q.sub.53 H COOEt Me OMe CH2003 Q.sub.53 H COOEt OMe OMe CH2004 Q.sub.53 Me COOMe Me OMe CH2005 Q.sub.53 Me COOMe OMe OMe CH2006 Q.sub.53 Me COOEt Me OMe CH2007 Q.sub.53 Me COOEt OMe OMe CH2008 Q.sub.53 H H Me OMe CH2009 Q.sub.53 H H OMe OMe CH2010 Me H Q.sub.53 Me OMe CH2011 Me H Q.sub.53 OMe OMe CH2012 Q.sub.54 H COOMe Me Me CH2013 Q.sub.54 H COOMe Me OMe CH2014 Q.sub.54 H COOMe OMe OMe CH2015 Q.sub.54 H COOMe Me OMe N2016 Q.sub.54 H COOMe OMe OMe N2017 Q.sub.54 H COOEt Me Me CH2018 Q.sub.54 H COOEt Me OMe CH2019 Q.sub.54 H COOEt OMe OMe CH2020 Q.sub.54 H COOEt Me OMe N2021 Q.sub.54 H COOEt OMe OMe N2022 Q.sub.54 Me COOMe Me OMe CH2023 Q.sub.54 Me COOMe OMe OMe CH2024 Q.sub.54 Me COOMe Me OMe N2025 Q.sub.54 Me COOEt Me OMe CH2026 Q.sub.54 Me COOEt OMe OMe CH2027 Q.sub.54 Me COOEt Me OMe N2028 Q.sub.54 H CN Me OMe CH2029 Q.sub.54 H CN OMe OMe CH2030 Q.sub.54 H CN Me OMe N2031 Q.sub.54 H H Me OMe CH2032 Q.sub.54 H H OMe OMe CH2033 Q.sub.54 H H Me OMe N2034 Me H Q.sub.54 Me Me CH2035 Me H Q.sub.54 Me OMe CH2036 Me H Q.sub.54 OMe OMe CH2037 Me H Q.sub.54 Me OMe N2038 Me H Q.sub.54 OMe OMe N2039 Q.sub.55 H COOMe Me Me CH2040 Q.sub.55 H COOMe Me OMe CH2041 Q.sub.55 H COOMe OMe OMe CH2042 Q.sub.55 H COOMe Me OMe N2043 Q.sub.55 H COOMe OMe OMe N2044 Q.sub.55 H COOEt Me Me CH2045 Q.sub.55 H COOEt Me OMe CH2046 Q.sub.55 H COOEt OMe OMe CH2047 Q.sub.55 H COOEt Me OMe N2048 Q.sub.55 H COOEt OMe OMe N2049 Q.sub.55 Me COOMe Me OMe CH2050 Q.sub.55 Me COOMe OMe OMe CH2051 Q.sub.55 Me COOMe Me OMe N2052 Q.sub.55 Me COOEt Me OMe CH2053 Q.sub.55 Me COOEt OMe OMe CH2054 Q.sub.55 Me COOEt Me OMe N2055 Q.sub.55 H CN Me OMe CH2056 Q.sub.55 H CN OMe OMe CH2057 Q.sub.55 H CN Me OMe N2058 Q.sub.55 H H Me OMe CH2059 Q.sub.55 H H OMe OMe CH2060 Q.sub.55 H H Me OMe N2061 Me H Q.sub.55 Me Me CH2062 Me H Q.sub.55 Me OMe CH2063 Me H Q.sub.55 OMe OMe CH2064 Me H Q.sub.55 Me OMe N2065 Me H Q.sub.55 OMe OMe N2066 Q.sub.56 H COOMe Me Me CH2067 Q.sub.56 H COOMe Me OMe CH2068 Q.sub.56 H COOMe OMe OMe CH2069 Q.sub.56 H COOMe Me OMe N2070 Q.sub.56 H COOMe OMe OMe N2071 Q.sub.56 H COOEt Me Me CH2072 Q.sub.56 H COOEt Me OMe CH2073 Q.sub.56 H COOEt OMe OMe CH2074 Q.sub.56 H COOEt Me OMe N2075 Q.sub.56 H COOEt OMe OMe N2076 Q.sub.56 Me COOMe Me OMe CH2077 Q.sub.56 Me COOMe OMe OMe CH2078 Q.sub.56 Me COOMe Me OMe N2079 Q.sub.56 Me COOEt Me OMe CH2080 Q.sub.56 Me COOEt OMe OMe CH2081 Q.sub.56 Me COOEt Me OMe N2082 Q.sub.56 H CN Me OMe CH2083 Q.sub.56 H CN OMe OMe CH2084 Q.sub.56 H CN Me OMe N2085 Q.sub.56 H H Me OMe CH2086 Q.sub.56 H H OMe OMe CH2087 Q.sub.56 H H Me OMe N2088 Me H Q.sub.56 Me Me CH2089 Me H Q.sub.56 Me OMe CH2090 Me H Q.sub.56 OMe OMe CH2091 Me H Q.sub.56 Me OMe N2092 Me H Q.sub.56 OMe OMe N2093 Q.sub.57 H COOMe Me OMe CH2094 Q.sub.57 H COOMe OMe OMe CH2095 Q.sub.57 H COOEt Me OMe CH2096 Q.sub.57 H COOEt OMe OMe CH2097 Q.sub.57 Me COOMe Me OMe CH2098 Q.sub.57 Me COOMe OMe OMe CH2099 Q.sub.57 Me COOEt Me OMe CH2100 Q.sub.57 Me COOEt OMe OMe CH2101 Q.sub.57 H H Me OMe CH2102 Q.sub.57 H H OMe OMe CH2103 Me H Q.sub.57 Me OMe CH2104 Me H Q.sub.57 OMe OMe CH2105 Q.sub.58 H COOMe Me OMe CH2106 Q.sub.58 H COOMe OMe OMe CH2107 Q.sub.58 H COOEt Me OMe CH2108 Q.sub.58 H COOEt OMe OMe CH2109 Q.sub.58 Me COOMe Me OMe CH2110 Q.sub.58 Me COOMe OMe OMe CH2111 Q.sub.58 Me COOEt Me OMe CH2112 Q.sub.58 Me COOEt OMe OMe CH2113 Q.sub.58 H H Me OMe CH2114 Q.sub.58 H H OMe OMe CH2115 Me H Q.sub.58 Me OMe CH2116 Me H Q.sub.58 OMe OMe CH2117 Q.sub.59 H COOMe Me Me CH2118 Q.sub.59 H COOMe Me OMe CH2119 Q.sub.59 H COOMe OMe OMe CH2120 Q.sub.59 H COOMe Me Me N2121 Q.sub.59 H COOMe Me OMe N2122 Q.sub.59 H COOMe OMe OMe N2123 Q.sub.59 H COOMe Me OCHF.sub.2 CH2124 Q.sub.59 H COOMe Cl OMe CH2125 Q.sub.59 H COOEt Me Me CH2126 Q.sub.59 H COOEt Me OMe CH2127 Q.sub.59 H COOEt OMe OMe CH2128 Q.sub.59 H COOEt Me Me N2129 Q.sub.59 H COOEt Me OMe N2130 Q.sub.59 H COOEt OMe OMe N2131 Q.sub.59 H COOEt Me OCHF.sub.2 CH2132 Q.sub.59 H COOEt Cl OMe CH2133 Q.sub.59 H COOPrn Me OMe CH2134 Q.sub.59 H COOPrn OMe OMe CH2135 Q.sub.59 H COOPrn Me OMe N2136 Q.sub.59 H COOPri Me OMe CH2137 Q.sub.59 H COOPri OMe OMe CH2138 Q.sub.59 H COOPri Me OMe N2139 Q.sub.59 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH2140 Q.sub.59 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH2141 Q.sub.59 H COOCH.sub.2 CH.sub.2 Cl Me OMe N2142 Q.sub.59 H COOCH.sub.2 CHCH.sub.2 Me OMe CH2143 Q.sub.59 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH2144 Q.sub.59 H COOCH.sub.2 CHCH.sub. 2 Me OMe N2145 Q.sub.59 H COOCH.sub.2 CCH Me OMe CH2146 Q.sub.59 H COOCH.sub.2 CCH OMe OMe CH2147 Q.sub.59 H COOCH.sub.2 CCH Me OMe N2148 Q.sub.59 Me COOMe Me Me CH2149 Q.sub.59 Me COOMe Me OMe CH2150 Q.sub.59 Me COOMe OMe OMe CH2151 Q.sub.59 Me COOMe Me OMe N2152 Q.sub.59 Me COOMe OMe OMe N2153 Q.sub.59 Me COOEt Me Me CH2154 Q.sub.59 Me COOEt Me OMe CH2155 Q.sub.59 Me COOEt OMe OMe CH2156 Q.sub.59 Me COOEt Me OMe N2157 Q.sub.59 Me COOEt OMe OMe N2158 Q.sub.59 Cl COOMe Me OMe CH2159 Q.sub.59 Cl COOMe OMe OMe CH2160 Q.sub.59 Cl COOMe Me OMe N2161 Q.sub.59 Cl COOEt Me OMe CH2162 Q.sub.59 Cl COOEt OMe OMe CH2163 Q.sub.59 Cl COOEt Me OMe N2164 Q.sub.59 OMe COOMe Me OMe CH2165 Q.sub.59 OMe COOMe OMe OMe CH2166 Q.sub.59 OMe COOMe Me OMe N2167 Q.sub.59 OMe COOEt Me OMe CH2168 Q.sub.59 OMe COOEt OMe OMe CH2169 Q.sub.59 OMe COOEt Me OMe N2170 Q.sub.59 H Cl Me OMe CH2171 Q.sub.59 H Cl OMe OMe CH2172 Q.sub.59 H Cl Me OMe N2173 Q.sub.59 H NO.sub.2 Me OMe CH2174 Q.sub.59 H NO.sub.2 OMe OMe CH2175 Q.sub.59 H NO.sub.2 Me OMe N2176 Q.sub.59 H SO.sub.2 NMe.sub.2 Me OMe CH2177 Q.sub.59 H SO.sub.2 NMe.sub.2 OMe OMe CH2178 Q.sub.59 H SO.sub.2 NMe.sub.2 Me OMe N2179 Q.sub.59 H CN Me OMe CH2180 Q.sub.59 H CN OMe OMe CH2181 Q.sub.59 H CN Me OMe N2182 Q.sub.59 Me CN Me OMe CH2183 Q.sub.59 Me CN OMe OMe CH2184 Q.sub.59 Me CN Me OMe N2185 Q.sub.59 H Me Me OMe CH2186 Q.sub.59 H Me OMe OMe CH2187 Q.sub.59 H Me Me OMe N2188 Q.sub.59 H Et Me OMe CH2189 Q.sub.59 H Et OMe OMe CH2190 Q.sub.59 H Et Me OMe N2191 Q.sub.59 H H Me OMe CH2192 Q.sub.59 H H OMe OMe CH2193 Q.sub.59 H H Me OMe N2194 Q.sub.59 H COPh Me OMe CH2195 Q.sub.59 H COPh OMe OMe CH2196 Q.sub.59 H COPh Me OMe N2197 Me Q.sub.59 COOMe Me OMe CH2198 Me Q.sub.59 COOMe OMe OMe CH2199 Me Q.sub.59 COOMe Me OMe N2200 H H Q.sub.59 Me OMe CH2201 H H Q.sub.59 OMe OMe CH2202 H H Q.sub.59 Me OMe N2203 Me H Q.sub.59 Me Me CH2204 Me H Q.sub.59 Me OMe CH2205 Me H Q.sub.59 OMe OMe CH2206 Me H Q.sub.59 Me OMe N2207 Me H Q.sub.59 OMe OMe N2208 Me Me Q.sub.59 Me OMe CH2209 Me Me Q.sub.59 OMe OMe CH2210 Me Me Q.sub.59 Me OMe N2211 Q.sub.60 H COOMe Me Me CH2212 Q.sub.60 H COOMe Me OMe CH2213 Q.sub.60 H COOMe OMe OMe CH2214 Q.sub.60 H COOMe Me OMe N2215 Q.sub.60 H COOMe OMe OMe N2216 Q.sub.60 H COOEt Me Me CH2217 Q.sub.60 H COOEt Me OMe CH2218 Q.sub.60 H COOEt OMe OMe CH2219 Q.sub.60 H COOEt Me OMe N2220 Q.sub.60 H COOEt OMe OMe N2221 Q.sub.60 Me COOMe Me OMe CH2222 Q.sub.60 Me COOMe OMe OMe CH2223 Q.sub.60 Me COOMe Me OMe N2224 Q.sub.60 Me COOEt Me OMe CH2225 Q.sub.60 Me COOEt OMe OMe CH2226 Q.sub.60 Me COOEt Me OMe N2227 Q.sub.60 H CN Me OMe CH2228 Q.sub.60 H CN OMe OMe CH2229 Q.sub.60 H CN Me OMe N2230 Q.sub.60 H H Me OMe CH2231 Q.sub.60 H H OMe OMe CH2232 Q.sub.60 H H Me OMe N2233 Me H Q.sub.60 Me Me CH2234 Me H Q.sub.60 Me OMe CH2235 Me H Q.sub.60 OMe OMe CH2236 Me H Q.sub.60 Me OMe N2237 Me H Q.sub.60 OMe OMe N2238 Q.sub.61 H COOMe Me Me CH2239 Q.sub.61 H COOMe Me OMe CH2240 Q.sub.61 H COOMe OMe OMe CH2241 Q.sub.61 H COOMe Me OMe N2242 Q.sub.61 H COOMe OMe OMe N2243 Q.sub.61 H COOEt Me Me CH2244 Q.sub.61 H COOEt Me OMe CH2245 Q.sub.61 H COOEt OMe OMe CH2246 Q.sub.61 H COOEt Me OMe N2247 Q.sub.61 H COOEt OMe OMe N2248 Q.sub.61 Me COOMe Me OMe CH2249 Q.sub.61 Me COOMe OMe OMe CH2250 Q.sub.61 Me COOMe Me OMe N2251 Q.sub.61 Me COOEt Me OMe CH2252 Q.sub.61 Me COOEt OMe OMe CH2253 Q.sub.61 Me COOEt Me OMe N2254 Q.sub.61 H CN Me OMe CH2255 Q.sub.61 H CN OMe OMe CH2256 Q.sub.61 H CN Me OMe N2257 Q.sub.61 H H Me OMe CH2258 Q.sub.61 H H OMe OMe CH2259 Q.sub.61 H H Me OMe N2260 Me H Q.sub.61 Me Me CH2261 Me H Q.sub.61 Me OMe CH2262 Me H Q.sub.61 OMe OMe CH2263 Me H Q.sub. 61 Me OMe N2264 Me H Q.sub.61 OMe OMe N2265 Q.sub.62 H COOMe Me Me CH2266 Q.sub.62 H COOMe Me OMe CH2267 Q.sub.62 H COOMe OMe OMe CH2268 Q.sub.62 H COOMe Me OMe N2269 Q.sub.62 H COOMe OMe OMe N2270 Q.sub.62 H COOEt Me Me CH2271 Q.sub.62 H COOEt Me OMe CH2272 Q.sub.62 H COOEt OMe OMe CH2273 Q.sub.62 H COOEt Me OMe N2274 Q.sub.62 H COOEt OMe OMe N2275 Q.sub.62 Me COOMe Me OMe CH2276 Q.sub.62 Me COOMe OMe OMe CH2277 Q.sub.62 Me COOMe Me OMe N2278 Q.sub.62 Me COOEt Me OMe CH2279 Q.sub.62 Me COOEt OMe OMe CH2280 Q.sub.62 Me COOEt Me OMe N2281 Q.sub.62 H CN Me OMe CH2282 Q.sub.62 H CN OMe OMe CH2283 Q.sub.62 H CN Me OMe N2284 Q.sub.62 H H Me OMe CH2285 Q.sub.62 H H OMe OMe CH2286 Q.sub.62 H H Me OMe N2287 Me H Q.sub.62 Me Me CH2288 Me H Q.sub. 62 Me OMe CH2289 Me H Q.sub.62 OMe OMe CH2290 Me H Q.sub.62 Me OMe N2291 Me H Q.sub.62 OMe OMe N2292 Q.sub.63 H COOMe Me OMe CH2293 Q.sub.63 H COOMe OMe OMe CH2294 Q.sub.63 H COOEt Me OMe CH2295 Q.sub.63 H COOEt OMe OMe CH2296 Q.sub.63 Me COOMe Me OMe CH2297 Q.sub.63 Me COOMe OMe OMe CH2298 Q.sub.63 Me COOEt Me OMe CH2299 Q.sub.63 Me COOEt OMe OMe CH2300 Q.sub.63 H H Me OMe CH2301 Q.sub.63 H H OMe OMe CH2302 Me H Q.sub.63 Me OMe CH2303 Me H Q.sub.63 OMe OMe CH2304 Q.sub.64 H COOMe Me OMe CH2305 Q.sub.64 H COOMe OMe OMe CH2306 Q.sub.64 H COOEt Me OMe CH2307 Q.sub.64 H COOEt OMe OMe CH2308 Q.sub.64 Me COOMe Me OMe CH2309 Q.sub.64 Me COOMe OMe OMe CH2310 Q.sub.64 Me COOEt Me OMe CH2311 Q.sub.64 Me COOEt OMe OMe CH2312 Q.sub.64 H H Me OMe CH2313 Q.sub.64 H H OMe OMe CH2314 Me H Q.sub.64 Me OMe CH2315 Me H Q.sub.64 OMe OMe CH2316 Q.sub.65 H COOMe Me Me CH2317 Q.sub.65 H COOMe Me OMe CH2318 Q.sub.65 H COOMe OMe OMe CH2319 Q.sub.65 H COOMe Me OMe N2320 Q.sub.65 H COOMe OMe OMe N2321 Q.sub.65 H COOEt Me Me CH2322 Q.sub.65 H COOEt Me OMe CH2323 Q.sub.65 H COOEt OMe OMe CH2324 Q.sub.65 H COOEt Me OMe N2325 Q.sub.65 H COOEt OMe OMe N2326 Q.sub.65 Me COOMe Me OMe CH2327 Q.sub.65 Me COOMe OMe OMe CH2328 Q.sub.65 Me COOMe Me OMe N2329 Q.sub.65 Me COOEt Me OMe CH2330 Q.sub.65 Me COOEt OMe OMe CH2331 Q.sub.65 Me COOEt Me OMe N2332 Q.sub.65 H CN Me OMe CH2333 Q.sub.65 H CN OMe OMe CH2334 Q.sub.65 H CN Me OMe N2335 Q.sub.65 H H Me OMe CH2336 Q.sub.65 H H OMe OMe CH2337 Q.sub.65 H H Me OMe N2338 Me H Q.sub. 65 Me Me CH2339 Me H Q.sub.65 Me OMe CH2340 Me H Q.sub.65 OMe OMe CH2341 Me H Q.sub.65 Me OMe N2342 Me H Q.sub.65 OMe OMe N2343 Q.sub.66 H COOMe Me OMe CH2344 Q.sub.66 H COOMe OMe OMe CH2345 Q.sub.66 H COOEt Me OMe CH2346 Q.sub.66 H COOEt OMe OMe CH2347 Q.sub.66 Me COOMe Me OMe CH2348 Q.sub.66 Me COOMe OMe OMe CH2349 Q.sub.66 Me COOEt Me OMe CH2350 Q.sub.66 Me COOEt OMe OMe CH2351 Q.sub.66 H H Me OMe CH2352 Q.sub.66 H H OMe OMe CH2353 Me H Q.sub.66 Me OMe CH2354 Me H Q.sub.66 OMe OMe CH2355 Q.sub.67 H COOMe Me OMe CH2356 Q.sub.67 H COOMe OMe OMe CH2357 Q.sub.67 H COOEt Me OMe CH2358 Q.sub.67 H COOEt OMe OMe CH2359 Q.sub.67 Me COOMe Me OMe CH2360 Q.sub.67 Me COOMe OMe OMe CH2361 Q.sub.67 Me COOEt Me OMe CH2362 Q.sub.67 Me COOEt OMe OMe CH2363 Q.sub.67 H H Me OMe CH2364 Q.sub.67 H H OMe OMe CH2365 Me H Q.sub.67 Me OMe CH2366 Me H Q.sub.67 OMe OMe CH2367 Q.sub.68 H COOMe Me OMe CH2368 Q.sub.68 H COOMe OMe OMe CH2369 Q.sub.68 H COOEt Me OMe CH2370 Q.sub.68 H COOEt OMe OMe CH2371 Q.sub.68 Me COOMe Me OMe CH2372 Q.sub.68 Me COOMe OMe OMe CH2373 Q.sub.68 Me COOEt Me OMe CH2374 Q.sub.68 Me COOEt OMe OMe CH2375 Q.sub.68 H H Me OMe CH2376 Q.sub.68 H H OMe OMe CH2377 Me H Q.sub.68 Me OMe CH2378 Me H Q.sub.68 Me OMe CH2379 Q.sub.69 H COOMe Me OMe CH2380 Q.sub.69 H COOMe OMe OMe CH2381 Q.sub.69 H COOEt Me OMe CH2382 Q.sub.69 H COOEt OMe OMe CH2383 Q.sub.69 Me COOMe Me OMe CH2384 Q.sub.69 Me COOMe OMe OMe CH2385 Q.sub.69 Me COOEt Me OMe CH2386 Q.sub.69 Me COOEt OMe OMe CH2387 Q.sub.69 H H Me OMe CH2388 Q.sub.69 H H OMe OMe CH2389 Me H Q.sub.69 Me OMe CH2390 Me H Q.sub.69 OMe OMe CH2391 Q.sub.70 H COOMe Me Me CH2392 Q.sub.70 H COOMe Me OMe CH2393 Q.sub.70 H COOMe OMe OMe CH2394 Q.sub.70 H COOMe Me OMe N2395 Q.sub.70 H COOMe OMe OMe N2396 Q.sub.70 H COOEt Me Me CH2397 Q.sub.70 H COOEt Me OMe CH2398 Q.sub.70 H COOEt OMe OMe CH2399 Q.sub.70 H COOEt Me OMe N2400 Q.sub.70 H COOEt OMe OMe N2401 Q.sub.70 Me COOMe Me OMe CH2402 Q.sub.70 Me COOMe OMe OMe CH2403 Q.sub.70 Me COOMe Me OMe N2404 Q.sub.70 Me COOEt Me OMe CH2405 Q.sub.70 Me COOEt OMe OMe CH2406 Q.sub.70 Me COOEt Me OMe N2407 Q.sub.70 H CN Me OMe CH2408 Q.sub.70 H CN OMe OMe CH2409 Q.sub.70 H CN Me OMe N2410 Q.sub.70 H H Me OMe CH2411 Q.sub.70 H H OMe OMe CH2412 Q.sub.70 H H Me OMe N2413 Me H Q.sub. 70 Me Me CH2414 Me H Q.sub.70 Me OMe CH2415 Me H Q.sub.70 OMe OMe CH2416 Me H Q.sub.70 Me OMe N2417 Me H Q.sub.70 OMe OMe N2418 Q.sub.71 H COOMe Me OMe CH2419 Q.sub.71 H COOMe OMe OMe CH2420 Q.sub.71 H COOEt Me OMe CH2421 Q.sub.71 H COOEt OMe OMe CH2422 Q.sub.71 Me COOMe Me OMe CH2423 Q.sub.71 Me COOMe OMe OMe CH2424 Q.sub.71 Me COOEt Me OMe CH2425 Q.sub.71 Me COOEt OMe OMe CH2426 Q.sub.71 H H Me OMe CH2427 Q.sub.71 H H OMe OMe CH2428 Me H Q.sub.71 Me OMe CH2429 Me H Q.sub.71 OMe OMe CH2430 Q.sub.72 H COOMe Me OMe CH2431 Q.sub.72 H COOMe OMe OMe CH2432 Q.sub.72 H COOEt Me OMe CH2433 Q.sub.72 H COOEt OMe OMe CH2434 Q.sub.72 Me COOMe Me OMe CH2435 Q.sub.72 Me COOMe OMe OMe CH2436 Q.sub.72 Me COOEt Me OMe CH2437 Q.sub.72 Me COOEt OMe OMe CH2438 Q.sub.72 H H Me OMe CH2439 Q.sub.72 H H OMe OMe CH2440 Me H Q.sub.72 Me OMe CH2441 Me H Q.sub.72 OMe OMe CH2442 Q.sub.73 H COOMe Me OMe CH2443 Q.sub.73 H COOMe OMe OMe CH2444 Q.sub.73 H COOEt Me OMe CH2445 Q.sub.73 H COOEt OMe OMe CH2446 Q.sub.73 Me COOMe Me OMe CH2447 Q.sub.73 Me COOMe OMe OMe CH2448 Q.sub.73 Me COOEt Me OMe CH2449 Q.sub.73 Me COOEt OMe OMe CH2450 Q.sub.73 H H Me OMe CH2451 Q.sub.73 H H OMe OMe CH2452 Me H Q.sub.73 Me OMe CH2453 Me H Q.sub.73 OMe OMe CH2454 Q.sub.74 H COOMe Me OMe CH2455 Q.sub.74 H COOMe OMe OMe CH2456 Q.sub.74 H COOEt Me OMe CH2457 Q.sub.74 H COOEt OMe OMe CH2458 Q.sub.74 Me COOMe Me OMe CH2459 Q.sub.74 Me COOMe OMe OMe CH2460 Q.sub.74 Me COOEt Me OMe CH2461 Q.sub.74 Me COOEt OMe OMe CH2462 Q.sub.74 H H Me OMe CH2463 Q.sub.74 H H OMe OMe CH2464 Me H Q.sub.74 Me OMe CH2465 Me H Q.sub.74 OMe OMe CH2466 Q.sub.75 H COOMe Me OMe CH2467 Q.sub.75 H COOMe OMe OMe CH2468 Q.sub.75 H COOEt Me OMe CH2469 Q.sub.75 H COOEt OMe OMe CH2470 Q.sub.75 Me COOMe Me OMe CH2471 Q.sub.75 Me COOMe OMe OMe CH2472 Q.sub.75 Me COOEt Me OMe CH2473 Q.sub.75 Me COOEt OMe OMe CH2474 Q.sub.75 H H Me OMe CH2475 Q.sub.75 H H OMe OMe CH2476 Me H Q.sub.75 Me OMe CH2477 Me H Q.sub.75 OMe OMe CH2478 Q.sub.76 H COOMe Me OMe CH2479 Q.sub.76 H COOMe OMe OMe CH2480 Q.sub.76 H COOEt Me OMe CH2481 Q.sub.76 H COOEt OMe OMe CH2482 Q.sub.76 Me COOMe Me OMe CH2483 Q.sub.76 Me COOMe OMe OMe CH2484 Q.sub.76 Me COOEt Me OMe CH2485 Q.sub.76 Me COOEt OMe OMe CH2486 Q.sub.76 H H Me OMe CH2487 Q.sub.76 H H OMe OMe CH2488 Me H Q.sub. 76 Me OMe CH2489 Me H Q.sub.76 OMe OMe CH5347 Q.sub.10 Me COOMe Me Me CH5348 Q.sub.77 H COOMe Me OMe CH5349 Q.sub.77 H COOMe OMe OMe CH5350 Q.sub.77 H COOEt Me OMe CH5351 Q.sub.77 H COOEt OMe OMe CH5352 Q.sub.77 Me COOMe Me OMe CH5353 Q.sub.77 Me COOMe OMe OMe CH5354 Q.sub.77 Me COOEt Me OMe CH5355 Q.sub.77 Me COOEt OMe OMe CH5356 Q.sub.77 H H Me OMe CH5357 Q.sub.77 H H OMe OMe CH5358 Me H Q.sub.77 Me OMe CH5359 Me H Q.sub.77 OMe OMe CH5360 Q.sub.78 H COOMe Me Me CH5361 Q.sub.78 H COOMe Me OMe CH5362 Q.sub.78 H COOMe OMe OMe CH5363 Q.sub.78 H COOMe Me Me N5364 Q.sub.78 H COOMe Me OMe N5365 Q.sub.78 H COOMe OMe OMe N5366 Q.sub.78 H COOMe Me OCHF.sub.2 CH5367 Q.sub.78 H COOMe Cl OMe CH5368 Q.sub.78 H COOEt Me Me CH5369 Q.sub.78 H COOEt Me OMe CH5370 Q.sub.78 H COOEt OMe OMe CH5371 Q.sub.78 H COOEt Me Me N5372 Q.sub.78 H COOEt Me OMe N5373 Q.sub.78 H COOEt OMe OMe N5374 Q.sub.78 H COOEt Me OCHF.sub.2 CH5375 Q.sub.78 H COOEt Cl OMe CH5376 Q.sub.78 H COOPrn Me OMe CH5377 Q.sub.78 H COOPrn OMe OMe CH5378 Q.sub.78 H COOPrn Me OMe N5379 Q.sub.78 H COOPri Me OMe CH5380 Q.sub.78 H COOPri OMe OMe CH5381 Q.sub.78 H COOPri Me OMe N5382 Q.sub.78 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH5383 Q.sub.78 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH5384 Q.sub.78 H COOCH.sub.2 CH.sub.2 Cl Me OMe N5385 Q.sub.78 H COOCH.sub.2 CHCH.sub.2 Me OMe CH5386 Q.sub.78 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH5387 Q.sub.78 H COOCH.sub.2 CHCH.sub.2 Me OMe N5388 Q.sub.78 H COOCH.sub.2 CCH Me OMe CH5389 Q.sub.78 H COOCH.sub.2 C CH OMe OMe CH5390 Q.sub.78 H COOCH.sub.2 CCH Me OMe N5391 Q.sub.78 Me COOMe Me Me CH5392 Q.sub.78 Me COOMe Me OMe CH5393 Q.sub.78 Me COOMe OMe OMe CH5394 Q.sub.78 Me COOMe Me OMe N5395 Q.sub.78 Me COOMe OMe OMe N5396 Q.sub.78 Me COOEt Me Me CH5397 Q.sub.78 Me COOEt Me OMe CH5398 Q.sub.78 Me COOEt OMe OMe CH5399 Q.sub.78 Me COOEt Me OMe N5400 Q.sub.78 Me COOEt OMe OMe N5401 Q.sub.78 Cl COOMe Me OMe CH5402 Q.sub.78 Cl COOMe OMe OMe CH5403 Q.sub.78 Cl COOMe Me OMe N5404 Q.sub.78 Cl COOEt Me OMe CH5405 Q.sub.78 Cl COOEt OMe OMe CH5406 Q.sub.78 Cl COOEt Me OMe N5407 Q.sub.78 OMe COOMe Me OMe CH5408 Q.sub.78 OMe COOMe OMe OMe CH5409 Q.sub.78 OMe COOMe Me OMe N5410 Q.sub.78 OMe COOEt Me OMe CH5411 Q.sub.78 OMe COOEt OMe OMe CH5412 Q.sub.78 OMe COOEt Me OMe N5413 Q.sub.78 H Cl Me OMe CH5414 Q.sub.78 H Cl OMe OMe CH5415 Q.sub.78 H Cl Me OMe N5416 Q.sub.78 H NO.sub.2 Me OMe CH5417 Q.sub.78 H NO.sub.2 OMe OMe CH5418 Q.sub.78 H NO.sub.2 Me OMe N5419 Q.sub.78 H SO.sub.2 NMe.sub.2 Me OMe CH5420 Q.sub.78 H SO.sub.2 NMe.sub.2 OMe OMe CH5421 Q.sub.78 H SO.sub.2 NMe.sub.2 Me OMe N5422 Q.sub.78 H CN Me OMe CH5423 Q.sub.78 H CN OMe OMe CH5424 Q.sub.78 H CN Me OMe N5425 Q.sub.78 Me CN Me OMe CH5426 Q.sub.78 Me CN OMe OMe CH5427 Q.sub.78 Me CN Me OMe N5428 Q.sub.78 H Me Me OMe CH5429 Q.sub.78 H Me OMe OMe CH5430 Q.sub.78 H Me Me OMe N5431 Q.sub.78 H Et Me OMe CH5432 Q.sub.78 H Et OMe OMe CH5433 Q.sub.78 H Et Me OMe N5434 Q.sub.78 H H Me OMe CH5435 Q.sub.78 H H OMe OMe CH5436 Q.sub.78 H H Me OMe N5437 Q.sub.78 H COPh Me OMe CH5438 Q.sub.78 H COPh OMe OMe CH5439 Q.sub.78 H COPh Me OMe N5440 Me Q.sub.78 COOMe Me OMe CH5441 Me Q.sub.78 COOMe OMe OMe CH5442 Me Q.sub.78 COOMe Me OMe N5443 H H Q.sub.78 Me OMe CH5444 H H Q.sub.78 OMe OMe CH5445 H H Q.sub.78 Me OMe N5446 Me H Q.sub.78 Me Me CH5447 Me H Q.sub.78 Me OMe CH5448 Me H Q.sub.78 OMe OMe CH5449 Me H Q.sub.78 Me OMe N5450 Me H Q.sub.78 OMe OMe N5451 Me Me Q.sub.78 Me OMe CH5452 Me Me Q.sub.78 OMe OMe CH5453 Me Me Q.sub.78 Me OMe N5454 Q.sub.79 H COOMe Me Me CH5455 Q.sub.79 H COOMe Me OMe CH5456 Q.sub.79 H COOMe OMe OMe CH5457 Q.sub.79 H COOMe Me Me N5458 Q.sub.79 H COOMe Me OMe N5459 Q.sub.79 H COOMe OMe OMe N5460 Q.sub.79 H COOMe Me OCHF.sub.2 CH5461 Q.sub.79 H COOMe Cl OMe CH5462 Q.sub.79 H COOEt Me Me CH5463 Q.sub.79 H COOEt Me OMe CH5464 Q.sub.79 H COOEt OMe OMe CH5465 Q.sub.79 H COOEt Me Me N5466 Q.sub.79 H COOEt Me OMe N5467 Q.sub.79 H COOEt OMe OMe N5468 Q.sub.79 H COOEt Me OCHF.sub.2 CH5469 Q.sub.79 H COOEt Cl OMe CH5470 Q.sub.79 H COOPrn Me OMe CH5471 Q.sub.79 H COOPrn OMe OMe CH5472 Q.sub.79 H COOPrn Me OMe N5473 Q.sub.79 H COOPri Me OMe CH5474 Q.sub.79 H COOPri OMe OMe CH5475 Q.sub.79 H COOPri Me OMe N5476 Q.sub.79 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH5477 Q.sub.79 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH5478 Q.sub.79 H COOCH.sub.2 CH.sub.2 Cl Me OMe N5479 Q.sub.79 H COOCH.sub.2 CHCH.sub.2 Me OMe CH5480 Q.sub.79 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH5481 Q.sub.79 H COOCH.sub.2 CHCH.sub. 2 Me OMe N5482 Q.sub.79 H COOCH.sub.2 CCH Me OMe CH5483 Q.sub.79 H COOCH.sub.2 CCH OMe OMe CH5484 Q.sub.79 H COOCH.sub.2 CCH Me OMe N5485 Q.sub.79 Me COOMe Me Me CH5486 Q.sub.79 Me COOMe Me OMe CH5487 Q.sub.79 Me COOMe OMe OMe CH5488 Q.sub.79 Me COOMe Me OMe N5489 Q.sub.79 Me COOMe OMe OMe N5490 Q.sub.79 Me COOEt Me Me CH5491 Q.sub.79 Me COOEt Me OMe CH5492 Q.sub.79 Me COOEt OMe OMe CH5493 Q.sub.79 Me COOEt Me OMe N5494 Q.sub.79 Me COOEt OMe OMe N5495 Q.sub.79 Cl COOMe Me OMe CH5496 Q.sub.79 Cl COOMe OMe OMe CH5497 Q.sub.79 Cl COOMe Me OMe N5498 Q.sub.79 Cl COOEt Me OMe CH5499 Q.sub.79 Cl COOEt OMe OMe CH5500 Q.sub.79 Cl COOEt Me OMe N5501 Q.sub.79 OMe COOMe Me OMe CH5502 Q.sub.79 OMe COOMe OMe OMe CH5503 Q.sub.79 OMe COOMe Me OMe N5504 Q.sub.79 OMe COOEt Me OMe CH5505 Q.sub.79 OMe COOEt OMe OMe CH5506 Q.sub.79 OMe COOEt Me OMe N5507 Q.sub.79 H Cl Me OMe CH5508 Q.sub.79 H Cl OMe OMe CH5509 Q.sub.79 H Cl Me OMe N5510 Q.sub.79 H NO.sub.2 Me OMe CH5511 Q.sub.79 H NO.sub.2 OMe OMe CH5512 Q.sub.79 H NO.sub.2 Me OMe N5513 Q.sub.79 H SO.sub.2 NMe.sub.2 Me OMe CH5514 Q.sub.79 H SO.sub.2 NMe.sub.2 OMe OMe CH5515 Q.sub.79 H SO.sub.2 NMe.sub.2 Me OMe N5516 Q.sub.79 H CN Me OMe CH5517 Q.sub.79 H CN OMe OMe CH5518 Q.sub.79 H CN Me OMe N5519 Q.sub.79 Me CN Me OMe CH5520 Q.sub.79 Me CN OMe OMe CH5521 Q.sub.79 Me CN Me OMe N5522 Q.sub.79 H Me Me OMe CH5523 Q.sub.79 H Me OMe OMe CH5524 Q.sub.79 H Me Me OMe N5525 Q.sub.79 H Et Me OMe CH5526 Q.sub.79 H Et OMe OMe CH5527 Q.sub.79 H Et Me OMe N5528 Q.sub.79 H H Me OMe CH5529 Q.sub.79 H H OMe OMe CH5530 Q.sub.79 H H Me OMe N5531 Q.sub.79 H COPh Me OMe CH5532 Q.sub.79 H COPh OMe OMe CH5533 Q.sub.79 H COPh Me OMe N5534 Me Q.sub.79 COOMe Me OMe CH5535 Me Q.sub.79 COOMe OMe OMe CH5536 Me Q.sub.79 COOMe Me OMe N5537 H H Q.sub.79 Me OMe CH5538 H H Q.sub.79 OMe OMe CH5539 H H Q.sub.79 Me OMe N5540 Me H Q.sub.79 Me Me CH5541 Me H Q.sub.79 Me OMe CH5542 Me H Q.sub.79 OMe OMe CH5543 Me H Q.sub.79 Me OMe N5544 Me H Q.sub.79 OMe OMe N5545 Me Me Q.sub.79 Me OMe CH5546 Me Me Q.sub.79 OMe OMe CH5547 Me Me Q.sub.79 Me OMe N5548 Q.sub.80 H COOMe Me Me CH5549 Q.sub.80 H COOMe Me OMe CH5550 Q.sub.80 H COOMe OMe OMe CH5551 Q.sub.80 H COOMe Me OMe N5552 Q.sub.80 H COOMe OMe OMe N5553 Q.sub.80 H COOEt Me Me CH5554 Q.sub.80 H COOEt Me OMe CH5555 Q.sub.80 H COOEt OMe OMe CH5556 Q.sub.80 H COOEt Me OMe N5557 Q.sub.80 H COOEt OMe OMe N5558 Q.sub.80 Me COOMe Me OMe CH5559 Q.sub.80 Me COOMe OMe OMe CH5560 Q.sub.80 Me COOMe Me OMe N5561 Q.sub.80 Me COOEt Me OMe CH5562 Q.sub.80 Me COOEt OMe OMe CH5563 Q.sub.80 Me COOEt Me OMe N5564 Q.sub.80 H CN Me OMe CH5565 Q.sub.80 H CN OMe OMe CH5566 Q.sub.80 H CN Me OMe N5567 Q.sub.80 H H Me OMe CH5568 Q.sub.80 H H OMe OMe CH5569 Q.sub.80 H H Me OMe N5570 Me H Q.sub.80 Me Me CH5571 Me H Q.sub.80 Me OMe CH5572 Me H Q.sub.80 OMe OMe CH5573 Me H Q.sub.80 Me OMe N5574 Me H Q.sub.80 OMe OMe N5575 Q.sub.81 H COOMe Me OMe CH5576 Q.sub.81 H COOMe OMe OMe CH5577 Q.sub.81 H COOEt Me OMe CH5578 Q.sub.81 H COOEt OMe OMe CH5579 Q.sub.81 Me COOMe Me OMe CH5580 Q.sub.81 Me COOMe OMe OMe CH5581 Q.sub.81 Me COOEt Me OMe CH5582 Q.sub.81 Me COOEt OMe OMe CH5583 Q.sub.81 H H Me OMe CH5584 Q.sub.81 H H OMe OMe CH5585 Me H Q.sub.81 Me OMe CH5586 Me H Q.sub.81 OMe OMe CH5587 Q.sub.82 H COOMe Me OMe CH5588 Q.sub.82 H COOMe OMe OMe CH5589 Q.sub.82 H COOEt Me OMe CH5590 Q.sub.82 H COOEt OMe OMe CH5591 Q.sub.82 Me COOMe Me OMe CH5592 Q.sub.82 Me COOMe OMe OMe CH5593 Q.sub.82 Me COOEt Me OMe CH5594 Q.sub.82 Me COOEt OMe OMe CH5595 Q.sub.82 H H Me OMe CH5596 Q.sub.82 H H OMe OMe CH5597 Me H Q.sub.82 Me OMe CH5598 Me H Q.sub.82 OMe OMe CH5599 Q.sub.83 H COOMe Me OMe CH5600 Q.sub.83 H COOMe OMe OMe CH5601 Q.sub.83 H COOEt Me OMe CH5602 Q.sub.83 H COOEt OMe OMe CH5603 Q.sub.83 Me COOMe Me OMe CH5604 Q.sub.83 Me COOMe OMe OMe CH5605 Q.sub.83 Me COOEt Me OMe CH5606 Q.sub.83 Me COOEt OMe OMe CH5607 Q.sub.83 H H Me OMe CH5608 Q.sub.83 H H OMe OMe CH5609 Me H Q.sub.83 Me OMe CH5610 Me H Q.sub.83 OMe OMe CH__________________________________________________________________________
__________________________________________________________________________1776 Q.sub.45 Cl COOEt Me OMe CH1777 Q.sub.45 Cl COOEt OMe OMe CH1778 Q.sub.45 Cl COOEt Me OMe N1779 Q.sub.45 OMe COOMe Me OMe CH1780 Q.sub.45 OMe COOMe OMe OMe CH1781 Q.sub.45 OMe COOMe Me OMe N1782 Q.sub.45 OMe COOEt Me OMe CH1783 Q.sub.45 OMe COOEt OMe OMe CH1784 Q.sub.45 OMe COOEt Me OMe N1785 Q.sub.45 H Cl Me OMe CH1786 Q.sub.45 H Cl OMe OMe CH1787 Q.sub.45 H Cl Me OMe N1788 Q.sub.45 H NO.sub.2 Me OMe CH1789 Q.sub.45 H NO.sub.2 OMe OMe CH1790 Q.sub.45 H NO.sub.2 Me OMe N1791 Q.sub.45 H SO.sub.2 NMe.sub.2 Me OMe CH1792 Q.sub.45 H SO.sub.2 NMe.sub.2 OMe OMe CH1793 Q.sub.45 H SO.sub.2 NMe.sub.2 Me OMe N1794 Q.sub.45 H CN Me OMe CH1795 Q.sub.45 H CN OMe OMe CH1796 Q.sub.45 H CN Me OMe N1797 Q.sub.45 Me CN Me OMe CH1798 Q.sub.45 Me CN OMe OMe CH1799 Q.sub.45 Me CN Me OMe N1800 Q.sub.45 H Me Me OMe CH1801 Q.sub.45 H Me OMe OMe CH1802 Q.sub.45 H Me Me OMe N1803 Q.sub.45 H Et Me OMe CH1804 Q.sub.45 H Et OMe OMe CH1805 Q.sub.45 H Et Me OMe N1806 Q.sub.45 H H Me OMe CH1807 Q.sub.45 H H OMe OMe CH1808 Q.sub.45 H H Me OMe N1809 Q.sub.45 H COPh Me OMe CH1810 Q.sub.45 H COPh OMe OMe CH1811 Q.sub.45 H COPh Me OMe N1812 Me Q.sub.45 COOMe Me OMe CH1813 Me Q.sub.45 COOMe OMe OMe CH1814 Me Q.sub.45 COOMe Me OMe N1815 H H Q.sub.45 Me OMe CH1816 H H Q.sub.45 OMe OMe CH1817 H H Q.sub.45 Me OMe N1818 Me H Q.sub.45 Me Me CH1819 Me H Q.sub.45 Me OMe CH1820 Me H Q.sub.45 OMe OMe CH1821 Me H Q.sub.45 Me OMe N1822 Me H Q.sub.45 OMe OMe N1823 Me Me Q.sub.45 Me OMe CH1824 Me Me Q.sub.45 OMe OMe CH1825 Me Me Q.sub.45 Me OMe N1826 Q.sub.46 H COOMe Me Me CH1827 Q.sub.46 H COOMe Me OMe CH1828 Q.sub.46 H COOMe OMe OMe CH1829 Q.sub.46 H COOMe Me OMe N1830 Q.sub.46 H COOMe OMe OMe N1831 Q.sub.46 H COOEt Me Me CH1832 Q.sub.46 H COOEt Me OMe CH1833 Q.sub.46 H COOEt OMe OMe CH1834 Q.sub.46 H COOEt Me OMe N1835 Q.sub.46 H COOEt OMe OMe N1836 Q.sub.46 Me COOMe Me OMe CH1837 Q.sub.46 Me COOMe OMe OMe CH1838 Q.sub.46 Me COOMe Me OMe N1839 Q.sub.46 Me COOEt Me OMe CH1840 Q.sub.46 Me COOEt OMe OMe CH1841 Q.sub.46 Me COOEt Me OMe N1842 Q.sub.46 H CN Me OMe CH1843 Q.sub.46 H CN OMe OMe CH1844 Q.sub.46 H CN Me OMe N1845 Q.sub.46 H H Me OMe CH1846 Q.sub.46 H H OMe OMe CH1847 Q.sub.46 H H Me OMe N1848 Me H Q.sub.46 Me Me CH1849 Me H Q.sub.46 Me OMe CH1850 Me H Q.sub.46 OMe OMe CH1851 Me H Q.sub.46 Me OMe N1852 Me H Q.sub.46 OMe OMe N1853 Q.sub.47 H COOMe Me Me CH1854 Q.sub.47 H COOMe Me OMe CH1855 Q.sub.47 H COOMe OMe OMe CH1856 Q.sub.47 H COOMe Me OMe N1857 Q.sub.47 H COOMe OMe OMe N1858 Q.sub.47 H COOEt Me Me CH1859 Q.sub.47 H COOEt Me OMe CH1860 Q.sub.47 H COOEt OMe OMe CH1861 Q.sub.47 H COOEt Me OMe N1862 Q.sub.47 H COOEt OMe OMe N1863 Q.sub.47 Me COOMe Me OMe CH1864 Q.sub.47 Me COOMe OMe OMe CH1865 Q.sub.47 Me COOMe Me OMe N1866 Q.sub.47 Me COOEt Me OMe CH1867 Q.sub.47 Me COOEt OMe OMe CH1868 Q.sub.47 Me COOEt Me OMe N1869 Q.sub.47 H CN Me OMe CH1870 Q.sub.47 H CN OMe OMe CH1871 Q.sub.47 H CN Me OMe N1872 Q.sub.47 H H Me OMe CH1873 Q.sub.47 H H OMe OMe CH1874 Q.sub.47 H H Me OMe N1875 Me H Q.sub.47 Me Me CH1876 Me H Q.sub.47 Me OMe CH1877 Me H Q.sub.47 OMe OMe CH1878 Me H Q.sub.47 Me OMe N1879 Me H Q.sub.47 OMe OMe N1880 Q.sub.48 H COOMe Me Me CH1881 Q.sub.48 H COOMe Me OMe CH1882 Q.sub.48 H COOMe OMe OMe CH1883 Q.sub.48 H COOMe Me OMe N1884 Q.sub.48 H COOMe OMe OMe N1885 Q.sub.48 H COOEt Me Me CH1886 Q.sub.48 H COOEt Me OMe CH1887 Q.sub.48 H COOEt OMe OMe CH1888 Q.sub.48 H COOEt Me OMe N1889 Q.sub.48 H COOEt OMe OMe N1890 Q.sub.48 Me COOMe Me OMe CH1891 Q.sub.48 Me COOMe OMe OMe CH1892 Q.sub.48 Me COOMe Me OMe N1893 Q.sub.48 Me COOEt Me OMe CH1894 Q.sub.48 Me COOEt OMe OMe CH1895 Q.sub.48 Me COOEt Me OMe N1896 Q.sub.48 H CN Me OMe CH1897 Q.sub.48 H CN OMe OMe CH1898 Q.sub.48 H CN Me OMe N1899 Q.sub.48 H H Me OMe CH1900 Q.sub.48 H H OMe OMe CH1901 Q.sub.48 H H Me OMe N1902 Me H Q.sub.48 Me Me CH1903 Me H Q.sub.48 Me OMe CH1904 Me H Q.sub.48 OMe OMe CH1905 Me H Q.sub.48 Me OMe N1906 Me H Q.sub.48 OMe OMe N1907 Q.sub.49 H COOMe Me Me CH1908 Q.sub.49 H COOMe Me OMe CH1909 Q.sub.49 H COOMe OMe OMe CH1910 Q.sub.49 H COOMe Me OMe N1911 Q.sub.49 H COOMe OMe OMe N1912 Q.sub.49 H COOEt Me Me CH1913 Q.sub.49 H COOEt Me OMe CH1914 Q49 H COOEt OMe OMe CH1915 Q.sub.49 H COOEt Me OMe N1916 Q.sub.49 H COOEt OMe OMe N1917 Q.sub.49 Me COOMe Me OMe CH1918 Q.sub.49 Me COOMe OMe OMe CH1919 Q.sub.49 Me COOMe Me OMe N1920 Q.sub.49 Me COOEt Me OMe CH1921 Q.sub.49 Me COOEt OMe OMe CH1922 Q.sub.49 Me COOEt Me OMe N1923 Q.sub.49 H CN Me OMe CH1924 Q.sub.49 H CN OMe OMe CH1925 Q.sub.49 H CN Me OMe N1926 Q.sub.49 H H Me OMe CH1927 Q.sub.49 H H OMe OMe CH1928 Q.sub.49 H H Me OMe N1929 Me H Q.sub.49 Me Me CH1930 Me H Q.sub.49 Me OMe CH1931 Me H Q.sub.49 OMe OMe CH1932 Me H Q.sub.49 Me OMe N1933 Me H Q.sub.49 OMe OMe N1934 Q.sub.50 H COOMe Me Me CH1935 Q.sub.50 H COOMe Me OMe CH1936 Q.sub.50 H COOMe OMe OMe CH1937 Q.sub.50 H COOMe Me OMe N1938 Q.sub.50 H COOMe OMe OMe N1939 Q.sub.50 H COOEt Me Me CH1940 Q.sub.50 H COOEt Me OMe CH1941 Q.sub.50 H COOEt OMe OMe CH1942 Q.sub.50 H COOEt Me OMe N1943 Q.sub.50 H COOEt OMe OMe N1944 Q.sub.50 Me COOMe Me OMe CH1945 Q.sub.50 Me COOMe OMe OMe CH1946 Q.sub.50 Me COOMe Me OMe N1947 Q.sub.50 Me COOEt Me OMe CH1948 Q.sub.50 Me COOEt OMe OMe CH1949 Q.sub.50 Me COOEt Me OMe N1950 Q.sub.50 H CN Me OMe CH1951 Q.sub.50 H CN OMe OMe CH1952 Q.sub.50 H CN Me OMe N1953 Q.sub.50 H H Me OMe CH1954 Q.sub.50 H H OMe OMe CH1955 Q.sub.50 H H Me OMe N1956 Me H Q.sub.50 Me Me CH1957 Me H Q.sub.50 Me OMe CH1958 Me H Q.sub.50 OMe OMe CH1959 Me H Q.sub.50 Me OMe N1960 Me H Q.sub.50 OMe OMe N1961 Q.sub.51 H COOMe Me Me CH1962 Q.sub.51 H COOMe Me OMe CH1963 Q.sub.51 H COOMe OMe OMe CH1964 Q.sub.51 H COOMe Me OMe N1965 Q.sub.51 H COOMe OMe OMe N1966 Q.sub.51 H COOEt Me Me CH1967 Q.sub.51 H COOEt Me OMe CH1968 Q.sub.51 H COOEt OMe OMe CH1969 Q.sub.51 H COOEt Me OMe N1970 Q.sub.51 H COOEt OMe OMe N1971 Q.sub.51 Me COOMe Me OMe CH1972 Q.sub.51 Me COOMe OMe OMe CH1973 Q.sub.51 Me COOMe Me OMe N1974 Q.sub.51 Me COOEt Me OMe CH1975 Q.sub.51 Me COOEt OMe OMe CH1976 Q.sub.51 Me COOEt Me OMe N1977 Q.sub.51 H CN Me OMe CH1978 Q.sub.51 H CN OMe OMe CH1979 Q.sub.51 H CN Me OMe N1980 Q.sub.51 H H Me OMe CH1981 Q.sub.51 H H OMe OMe CH1982 Q.sub.51 H H Me OMe N1983 Me H Q.sub.51 Me Me CH1984 Me H Q.sub.51 Me OMe CH1985 Me H Q.sub.51 OMe OMe CH1986 Me H Q.sub.51 Me OMe N1987 Me H Q.sub.51 OMe OMe N1988 Q.sub.52 H COOMe Me OMe CH1989 Q.sub.52 H COOMe OMe OMe CH1990 Q.sub.52 H COOEt Me OMe CH1991 Q.sub.52 H COOEt OMe OMe CH1992 Q.sub.52 Me COOMe Me OMe CH1993 Q.sub.52 Me COOMe OMe OMe CH1994 Q.sub.52 Me COOEt Me OMe CH1995 Q.sub.52 Me COOEt OMe OMe CH1996 Q.sub.52 H H Me OMe CH1997 Q.sub.52 H H OMe OMe CH1998 Me H Q.sub. 52 Me OMe CH1999 Me H Q.sub.52 OMe OMe CH2000 Q.sub.53 H COOMe Me OMe CH2001 Q.sub.53 H COOMe OMe OMe CH2002 Q.sub.53 H COOEt Me OMe CH2003 Q.sub.53 H COOEt OMe OMe CH2004 Q.sub.53 Me COOMe Me OMe CH2005 Q.sub.53 Me COOMe OMe OMe CH2006 Q.sub.53 Me COOEt Me OMe CH2007 Q.sub.53 Me COOEt OMe OMe CH2008 Q.sub.53 H H Me OMe CH2009 Q.sub.53 H H OMe OMe CH2010 Me H Q.sub.53 Me OMe CH2011 Me H Q.sub.53 OMe OMe CH2012 Q.sub.54 H COOMe Me Me CH2013 Q.sub.54 H COOMe Me OMe CH2014 Q.sub.54 H COOMe OMe OMe CH2015 Q.sub.54 H COOMe Me OMe N2016 Q.sub.54 H COOMe OMe OMe N2017 Q.sub.54 H COOEt Me Me CH2018 Q.sub.54 H COOEt Me OMe CH2019 Q.sub.54 H COOEt OMe OMe CH2020 Q.sub.54 H COOEt Me OMe N2021 Q.sub.54 H COOEt OMe OMe N2022 Q.sub.54 Me COOMe Me OMe CH2023 Q.sub.54 Me COOMe OMe OMe CH2024 Q.sub.54 Me COOMe Me OMe N2025 Q.sub.54 Me COOEt Me OMe CH2026 Q.sub.54 Me COOEt OMe OMe CH2027 Q.sub.54 Me COOEt Me OMe N2028 Q.sub.54 H CN Me OMe CH2029 Q.sub.54 H CN OMe OMe CH2030 Q.sub.54 H CN Me OMe N2031 Q.sub.54 H H Me OMe CH2032 Q.sub.54 H H OMe OMe CH2033 Q.sub.54 H H Me OMe N2034 Me H Q.sub.54 Me Me CH2035 Me H Q.sub.54 Me OMe CH2036 Me H Q.sub.54 OMe OMe CH2037 Me H Q.sub.54 Me OMe N2038 Me H Q.sub.54 OMe OMe N2039 Q.sub.55 H COOMe Me Me CH2040 Q.sub.55 H COOMe Me OMe CH2041 Q.sub.55 H COOMe OMe OMe CH2042 Q.sub.55 H COOMe Me OMe N2043 Q.sub.55 H COOMe OMe OMe N2044 Q.sub.55 H COOEt Me Me CH2045 Q.sub.55 H COOEt Me OMe CH2046 Q.sub.55 H COOEt OMe OMe CH2047 Q.sub.55 H COOEt Me OMe N2048 Q.sub.55 H COOEt OMe OMe N2049 Q.sub.55 Me COOMe Me OMe CH2050 Q.sub.55 Me COOMe OMe OMe CH2051 Q.sub.55 Me COOMe Me OMe N2052 Q.sub.55 Me COOEt Me OMe CH2053 Q.sub.55 Me COOEt OMe OMe CH2054 Q.sub.55 Me COOEt Me OMe N2055 Q.sub.55 H CN Me OMe CH2056 Q.sub.55 H CN OMe OMe CH2057 Q.sub.55 H CN Me OMe N2058 Q.sub.55 H H Me OMe CH2059 Q.sub.55 H H OMe OMe CH2060 Q.sub.55 H H Me OMe N2061 Me H Q.sub.55 Me Me CH2062 Me H Q.sub.55 Me OMe CH2063 Me H Q.sub.55 OMe OMe CH2064 Me H Q.sub.55 Me OMe N2065 Me H Q.sub.55 OMe OMe N2066 Q.sub.56 H COOMe Me Me CH2067 Q.sub.56 H COOMe Me OMe CH2068 Q.sub.56 H COOMe OMe OMe CH2069 Q.sub.56 H COOMe Me OMe N2070 Q.sub.56 H COOMe OMe OMe N2071 Q.sub.56 H COOEt Me Me CH2072 Q.sub.56 H COOEt Me OMe CH2073 Q.sub.56 H COOEt OMe OMe CH2074 Q.sub.56 H COOEt Me OMe N2075 Q.sub.56 H COOEt OMe OMe N2076 Q.sub.56 Me COOMe Me OMe CH2077 Q.sub.56 Me COOMe OMe OMe CH2078 Q.sub.56 Me COOMe Me OMe N2079 Q.sub.56 Me COOEt Me OMe CH2080 Q.sub.56 Me COOEt OMe OMe CH2081 Q.sub.56 Me COOEt Me OMe N2082 Q.sub.56 H CN Me OMe CH2083 Q.sub.56 H CN OMe OMe CH2084 Q.sub.56 H CN Me OMe N2085 Q.sub.56 H H Me OMe CH2086 Q.sub.56 H H OMe OMe CH2087 Q.sub.56 H H Me OMe N2088 Me H Q.sub.56 Me Me CH2089 Me H Q.sub.56 Me OMe CH2090 Me H Q.sub.56 OMe OMe CH2091 Me H Q.sub.56 Me OMe N2092 Me H Q.sub.56 OMe OMe N2093 Q.sub.57 H COOMe Me OMe CH2094 Q.sub.57 H COOMe OMe OMe CH2095 Q.sub.57 H COOEt Me OMe CH2096 Q.sub.57 H COOEt OMe OMe CH2097 Q.sub.57 Me COOMe Me OMe CH2098 Q.sub.57 Me COOMe OMe OMe CH2099 Q.sub.57 Me COOEt Me OMe CH2100 Q.sub.57 Me COOEt OMe OMe CH2101 Q.sub.57 H H Me OMe CH2102 Q.sub.57 H H OMe OMe CH2103 Me H Q.sub.57 Me OMe CH2104 Me H Q.sub.57 OMe OMe CH2105 Q.sub.58 H COOMe Me OMe CH2106 Q.sub.58 H COOMe OMe OMe CH2107 Q.sub.58 H COOEt Me OMe CH2108 Q.sub.58 H COOEt OMe OMe CH2109 Q.sub.58 Me COOMe Me OMe CH2110 Q.sub.58 Me COOMe OMe OMe CH2111 Q.sub.58 Me COOEt Me OMe CH2112 Q.sub.58 Me COOEt OMe OMe CH2113 Q.sub.58 H H Me OMe CH2114 Q.sub.58 H H OMe OMe CH2115 Me H Q.sub.58 Me OMe CH2116 Me H Q.sub.58 OMe OMe CH2117 Q.sub.59 H COOMe Me Me CH2118 Q.sub.59 H COOMe Me OMe CH2119 Q.sub.59 H COOMe OMe OMe CH2120 Q.sub.59 H COOMe Me Me N2121 Q.sub.59 H COOMe Me OMe N2122 Q.sub.59 H COOMe OMe OMe N2123 Q.sub.59 H COOMe Me OCHF.sub.2 CH2124 Q.sub.59 H COOMe Cl OMe CH2125 Q.sub.59 H COOEt Me Me CH2126 Q.sub.59 H COOEt Me OMe CH2127 Q.sub.59 H COOEt OMe OMe CH2128 Q.sub.59 H COOEt Me Me N2129 Q.sub.59 H COOEt Me OMe N2130 Q.sub.59 H COOEt OMe OMe N2131 Q.sub.59 H COOEt Me OCHF.sub.2 CH2132 Q.sub.59 H COOEt Cl OMe CH2133 Q.sub.59 H COOPrn Me OMe CH2134 Q.sub.59 H COOPrn OMe OMe CH2135 Q.sub.59 H COOPrn Me OMe N2136 Q.sub.59 H COOPri Me OMe CH2137 Q.sub.59 H COOPri OMe OMe CH2138 Q.sub.59 H COOPri Me OMe N2139 Q.sub.59 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH2140 Q.sub.59 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH2141 Q.sub.59 H COOCH.sub.2 CH.sub.2 Cl Me OMe N2142 Q.sub.59 H COOCH.sub.2 CHCH.sub.2 Me OMe CH2143 Q.sub.59 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH2144 Q.sub.59 H COOCH.sub.2 CHCH.sub. 2 Me OMe N2145 Q.sub.59 H COOCH.sub.2 CCH Me OMe CH2146 Q.sub.59 H COOCH.sub.2 CCH OMe OMe CH2147 Q.sub.59 H COOCH.sub.2 CCH Me OMe N2148 Q.sub.59 Me COOMe Me Me CH2149 Q.sub.59 Me COOMe Me OMe CH2150 Q.sub.59 Me COOMe OMe OMe CH2151 Q.sub.59 Me COOMe Me OMe N2152 Q.sub.59 Me COOMe OMe OMe N2153 Q.sub.59 Me COOEt Me Me CH2154 Q.sub.59 Me COOEt Me OMe CH2155 Q.sub.59 Me COOEt OMe OMe CH2156 Q.sub.59 Me COOEt Me OMe N2157 Q.sub.59 Me COOEt OMe OMe N2158 Q.sub.59 Cl COOMe Me OMe CH2159 Q.sub.59 Cl COOMe OMe OMe CH2160 Q.sub.59 Cl COOMe Me OMe N2161 Q.sub.59 Cl COOEt Me OMe CH2162 Q.sub.59 Cl COOEt OMe OMe CH2163 Q.sub.59 Cl COOEt Me OMe N2164 Q.sub.59 OMe COOMe Me OMe CH2165 Q.sub.59 OMe COOMe OMe OMe CH2166 Q.sub.59 OMe COOMe Me OMe N2167 Q.sub.59 OMe COOEt Me OMe CH2168 Q.sub.59 OMe COOEt OMe OMe CH2169 Q.sub.59 OMe COOEt Me OMe N2170 Q.sub.59 H Cl Me OMe CH2171 Q.sub.59 H Cl OMe OMe CH2172 Q.sub.59 H Cl Me OMe N2173 Q.sub.59 H NO.sub.2 Me OMe CH2174 Q.sub.59 H NO.sub.2 OMe OMe CH2175 Q.sub.59 H NO.sub.2 Me OMe N2176 Q.sub.59 H SO.sub.2 NMe.sub.2 Me OMe CH2177 Q.sub.59 H SO.sub.2 NMe.sub.2 OMe OMe CH2178 Q.sub.59 H SO.sub.2 NMe.sub.2 Me OMe N2179 Q.sub.59 H CN Me OMe CH2180 Q.sub.59 H CN OMe OMe CH2181 Q.sub.59 H CN Me OMe N2182 Q.sub.59 Me CN Me OMe CH2183 Q.sub.59 Me CN OMe OMe CH2184 Q.sub.59 Me CN Me OMe N2185 Q.sub.59 H Me Me OMe CH2186 Q.sub.59 H Me OMe OMe CH2187 Q.sub.59 H Me Me OMe N2188 Q.sub.59 H Et Me OMe CH2189 Q.sub.59 H Et OMe OMe CH2190 Q.sub.59 H Et Me OMe N2191 Q.sub.59 H H Me OMe CH2192 Q.sub.59 H H OMe OMe CH2193 Q.sub.59 H H Me OMe N2194 Q.sub.59 H COPh Me OMe CH2195 Q.sub.59 H COPh OMe OMe CH2196 Q.sub.59 H COPh Me OMe N2197 Me Q.sub.59 COOMe Me OMe CH2198 Me Q.sub.59 COOMe OMe OMe CH2199 Me Q.sub.59 COOMe Me OMe N2200 H H Q.sub.59 Me OMe CH2201 H H Q.sub.59 OMe OMe CH2202 H H Q.sub.59 Me OMe N2203 Me H Q.sub.59 Me Me CH2204 Me H Q.sub.59 Me OMe CH2205 Me H Q.sub.59 OMe OMe CH2206 Me H Q.sub.59 Me OMe N2207 Me H Q.sub.59 OMe OMe N2208 Me Me Q.sub.59 Me OMe CH2209 Me Me Q.sub.59 OMe OMe CH2210 Me Me Q.sub.59 Me OMe N2211 Q.sub.60 H COOMe Me Me CH2212 Q.sub.60 H COOMe Me OMe CH2213 Q.sub.60 H COOMe OMe OMe CH2214 Q.sub.60 H COOMe Me OMe N2215 Q.sub.60 H COOMe OMe OMe N2216 Q.sub.60 H COOEt Me Me CH2217 Q.sub.60 H COOEt Me OMe CH2218 Q.sub.60 H COOEt OMe OMe CH2219 Q.sub.60 H COOEt Me OMe N2220 Q.sub.60 H COOEt OMe OMe N2221 Q.sub.60 Me COOMe Me OMe CH2222 Q.sub.60 Me COOMe OMe OMe CH2223 Q.sub.60 Me COOMe Me OMe N2224 Q.sub.60 Me COOEt Me OMe CH2225 Q.sub.60 Me COOEt OMe OMe CH2226 Q.sub.60 Me COOEt Me OMe N2227 Q.sub.60 H CN Me OMe CH2228 Q.sub.60 H CN OMe OMe CH2229 Q.sub.60 H CN Me OMe N2230 Q.sub.60 H H Me OMe CH2231 Q.sub.60 H H OMe OMe CH2232 Q.sub.60 H H Me OMe N2233 Me H Q.sub.60 Me Me CH2234 Me H Q.sub.60 Me OMe CH2235 Me H Q.sub.60 OMe OMe CH2236 Me H Q.sub.60 Me OMe N2237 Me H Q.sub.60 OMe OMe N2238 Q.sub.61 H COOMe Me Me CH2239 Q.sub.61 H COOMe Me OMe CH2240 Q.sub.61 H COOMe OMe OMe CH2241 Q.sub.61 H COOMe Me OMe N2242 Q.sub.61 H COOMe OMe OMe N2243 Q.sub.61 H COOEt Me Me CH2244 Q.sub.61 H COOEt Me OMe CH2245 Q.sub.61 H COOEt OMe OMe CH2246 Q.sub.61 H COOEt Me OMe N2247 Q.sub.61 H COOEt OMe OMe N2248 Q.sub.61 Me COOMe Me OMe CH2249 Q.sub.61 Me COOMe OMe OMe CH2250 Q.sub.61 Me COOMe Me OMe N2251 Q.sub.61 Me COOEt Me OMe CH2252 Q.sub.61 Me COOEt OMe OMe CH2253 Q.sub.61 Me COOEt Me OMe N2254 Q.sub.61 H CN Me OMe CH2255 Q.sub.61 H CN OMe OMe CH2256 Q.sub.61 H CN Me OMe N2257 Q.sub.61 H H Me OMe CH2258 Q.sub.61 H H OMe OMe CH2259 Q.sub.61 H H Me OMe N2260 Me H Q.sub.61 Me Me CH2261 Me H Q.sub.61 Me OMe CH2262 Me H Q.sub.61 OMe OMe CH2263 Me H Q.sub. 61 Me OMe N2264 Me H Q.sub.61 OMe OMe N2265 Q.sub.62 H COOMe Me Me CH2266 Q.sub.62 H COOMe Me OMe CH2267 Q.sub.62 H COOMe OMe OMe CH2268 Q.sub.62 H COOMe Me OMe N2269 Q.sub.62 H COOMe OMe OMe N2270 Q.sub.62 H COOEt Me Me CH2271 Q.sub.62 H COOEt Me OMe CH2272 Q.sub.62 H COOEt OMe OMe CH2273 Q.sub.62 H COOEt Me OMe N2274 Q.sub.62 H COOEt OMe OMe N2275 Q.sub.62 Me COOMe Me OMe CH2276 Q.sub.62 Me COOMe OMe OMe CH2277 Q.sub.62 Me COOMe Me OMe N2278 Q.sub.62 Me COOEt Me OMe CH2279 Q.sub.62 Me COOEt OMe OMe CH2280 Q.sub.62 Me COOEt Me OMe N2281 Q.sub.62 H CN Me OMe CH2282 Q.sub.62 H CN OMe OMe CH2283 Q.sub.62 H CN Me OMe N2284 Q.sub.62 H H Me OMe CH2285 Q.sub.62 H H OMe OMe CH2286 Q.sub.62 H H Me OMe N2287 Me H Q.sub.62 Me Me CH2288 Me H Q.sub. 62 Me OMe CH2289 Me H Q.sub.62 OMe OMe CH2290 Me H Q.sub.62 Me OMe N2291 Me H Q.sub.62 OMe OMe N2292 Q.sub.63 H COOMe Me OMe CH2293 Q.sub.63 H COOMe OMe OMe CH2294 Q.sub.63 H COOEt Me OMe CH2295 Q.sub.63 H COOEt OMe OMe CH2296 Q.sub.63 Me COOMe Me OMe CH2297 Q.sub.63 Me COOMe OMe OMe CH2298 Q.sub.63 Me COOEt Me OMe CH2299 Q.sub.63 Me COOEt OMe OMe CH2300 Q.sub.63 H H Me OMe CH2301 Q.sub.63 H H OMe OMe CH2302 Me H Q.sub.63 Me OMe CH2303 Me H Q.sub.63 OMe OMe CH2304 Q.sub.64 H COOMe Me OMe CH2305 Q.sub.64 H COOMe OMe OMe CH2306 Q.sub.64 H COOEt Me OMe CH2307 Q.sub.64 H COOEt OMe OMe CH2308 Q.sub.64 Me COOMe Me OMe CH2309 Q.sub.64 Me COOMe OMe OMe CH2310 Q.sub.64 Me COOEt Me OMe CH2311 Q.sub.64 Me COOEt OMe OMe CH2312 Q.sub.64 H H Me OMe CH2313 Q.sub.64 H H OMe OMe CH2314 Me H Q.sub.64 Me OMe CH2315 Me H Q.sub.64 OMe OMe CH2316 Q.sub.65 H COOMe Me Me CH2317 Q.sub.65 H COOMe Me OMe CH2318 Q.sub.65 H COOMe OMe OMe CH2319 Q.sub.65 H COOMe Me OMe N2320 Q.sub.65 H COOMe OMe OMe N2321 Q.sub.65 H COOEt Me Me CH2322 Q.sub.65 H COOEt Me OMe CH2323 Q.sub.65 H COOEt OMe OMe CH2324 Q.sub.65 H COOEt Me OMe N2325 Q.sub.65 H COOEt OMe OMe N2326 Q.sub.65 Me COOMe Me OMe CH2327 Q.sub.65 Me COOMe OMe OMe CH2328 Q.sub.65 Me COOMe Me OMe N2329 Q.sub.65 Me COOEt Me OMe CH2330 Q.sub.65 Me COOEt OMe OMe CH2331 Q.sub.65 Me COOEt Me OMe N2332 Q.sub.65 H CN Me OMe CH2333 Q.sub.65 H CN OMe OMe CH2334 Q.sub.65 H CN Me OMe N2335 Q.sub.65 H H Me OMe CH2336 Q.sub.65 H H OMe OMe CH2337 Q.sub.65 H H Me OMe N2338 Me H Q.sub. 65 Me Me CH2339 Me H Q.sub.65 Me OMe CH2340 Me H Q.sub.65 OMe OMe CH2341 Me H Q.sub.65 Me OMe N2342 Me H Q.sub.65 OMe OMe N2343 Q.sub.66 H COOMe Me OMe CH2344 Q.sub.66 H COOMe OMe OMe CH2345 Q.sub.66 H COOEt Me OMe CH2346 Q.sub.66 H COOEt OMe OMe CH2347 Q.sub.66 Me COOMe Me OMe CH2348 Q.sub.66 Me COOMe OMe OMe CH2349 Q.sub.66 Me COOEt Me OMe CH2350 Q.sub.66 Me COOEt OMe OMe CH2351 Q.sub.66 H H Me OMe CH2352 Q.sub.66 H H OMe OMe CH2353 Me H Q.sub.66 Me OMe CH2354 Me H Q.sub.66 OMe OMe CH2355 Q.sub.67 H COOMe Me OMe CH2356 Q.sub.67 H COOMe OMe OMe CH2357 Q.sub.67 H COOEt Me OMe CH2358 Q.sub.67 H COOEt OMe OMe CH2359 Q.sub.67 Me COOMe Me OMe CH2360 Q.sub.67 Me COOMe OMe OMe CH2361 Q.sub.67 Me COOEt Me OMe CH2362 Q.sub.67 Me COOEt OMe OMe CH2363 Q.sub.67 H H Me OMe CH2364 Q.sub.67 H H OMe OMe CH2365 Me H Q.sub.67 Me OMe CH2366 Me H Q.sub.67 OMe OMe CH2367 Q.sub.68 H COOMe Me OMe CH2368 Q.sub.68 H COOMe OMe OMe CH2369 Q.sub.68 H COOEt Me OMe CH2370 Q.sub.68 H COOEt OMe OMe CH2371 Q.sub.68 Me COOMe Me OMe CH2372 Q.sub.68 Me COOMe OMe OMe CH2373 Q.sub.68 Me COOEt Me OMe CH2374 Q.sub.68 Me COOEt OMe OMe CH2375 Q.sub.68 H H Me OMe CH2376 Q.sub.68 H H OMe OMe CH2377 Me H Q.sub.68 Me OMe CH2378 Me H Q.sub.68 Me OMe CH2379 Q.sub.69 H COOMe Me OMe CH2380 Q.sub.69 H COOMe OMe OMe CH2381 Q.sub.69 H COOEt Me OMe CH2382 Q.sub.69 H COOEt OMe OMe CH2383 Q.sub.69 Me COOMe Me OMe CH2384 Q.sub.69 Me COOMe OMe OMe CH2385 Q.sub.69 Me COOEt Me OMe CH2386 Q.sub.69 Me COOEt OMe OMe CH2387 Q.sub.69 H H Me OMe CH2388 Q.sub.69 H H OMe OMe CH2389 Me H Q.sub.69 Me OMe CH2390 Me H Q.sub.69 OMe OMe CH2391 Q.sub.70 H COOMe Me Me CH2392 Q.sub.70 H COOMe Me OMe CH2393 Q.sub.70 H COOMe OMe OMe CH2394 Q.sub.70 H COOMe Me OMe N2395 Q.sub.70 H COOMe OMe OMe N2396 Q.sub.70 H COOEt Me Me CH2397 Q.sub.70 H COOEt Me OMe CH2398 Q.sub.70 H COOEt OMe OMe CH2399 Q.sub.70 H COOEt Me OMe N2400 Q.sub.70 H COOEt OMe OMe N2401 Q.sub.70 Me COOMe Me OMe CH2402 Q.sub.70 Me COOMe OMe OMe CH2403 Q.sub.70 Me COOMe Me OMe N2404 Q.sub.70 Me COOEt Me OMe CH2405 Q.sub.70 Me COOEt OMe OMe CH2406 Q.sub.70 Me COOEt Me OMe N2407 Q.sub.70 H CN Me OMe CH2408 Q.sub.70 H CN OMe OMe CH2409 Q.sub.70 H CN Me OMe N2410 Q.sub.70 H H Me OMe CH2411 Q.sub.70 H H OMe OMe CH2412 Q.sub.70 H H Me OMe N2413 Me H Q.sub. 70 Me Me CH2414 Me H Q.sub.70 Me OMe CH2415 Me H Q.sub.70 OMe OMe CH2416 Me H Q.sub.70 Me OMe N2417 Me H Q.sub.70 OMe OMe N2418 Q.sub.71 H COOMe Me OMe CH2419 Q.sub.71 H COOMe OMe OMe CH2420 Q.sub.71 H COOEt Me OMe CH2421 Q.sub.71 H COOEt OMe OMe CH2422 Q.sub.71 Me COOMe Me OMe CH2423 Q.sub.71 Me COOMe OMe OMe CH2424 Q.sub.71 Me COOEt Me OMe CH2425 Q.sub.71 Me COOEt OMe OMe CH2426 Q.sub.71 H H Me OMe CH2427 Q.sub.71 H H OMe OMe CH2428 Me H Q.sub.71 Me OMe CH2429 Me H Q.sub.71 OMe OMe CH2430 Q.sub.72 H COOMe Me OMe CH2431 Q.sub.72 H COOMe OMe OMe CH2432 Q.sub.72 H COOEt Me OMe CH2433 Q.sub.72 H COOEt OMe OMe CH2434 Q.sub.72 Me COOMe Me OMe CH2435 Q.sub.72 Me COOMe OMe OMe CH2436 Q.sub.72 Me COOEt Me OMe CH2437 Q.sub.72 Me COOEt OMe OMe CH2438 Q.sub.72 H H Me OMe CH2439 Q.sub.72 H H OMe OMe CH2440 Me H Q.sub.72 Me OMe CH2441 Me H Q.sub.72 OMe OMe CH2442 Q.sub.73 H COOMe Me OMe CH2443 Q.sub.73 H COOMe OMe OMe CH2444 Q.sub.73 H COOEt Me OMe CH2445 Q.sub.73 H COOEt OMe OMe CH2446 Q.sub.73 Me COOMe Me OMe CH2447 Q.sub.73 Me COOMe OMe OMe CH2448 Q.sub.73 Me COOEt Me OMe CH2449 Q.sub.73 Me COOEt OMe OMe CH2450 Q.sub.73 H H Me OMe CH2451 Q.sub.73 H H OMe OMe CH2452 Me H Q.sub.73 Me OMe CH2453 Me H Q.sub.73 OMe OMe CH2454 Q.sub.74 H COOMe Me OMe CH2455 Q.sub.74 H COOMe OMe OMe CH2456 Q.sub.74 H COOEt Me OMe CH2457 Q.sub.74 H COOEt OMe OMe CH2458 Q.sub.74 Me COOMe Me OMe CH2459 Q.sub.74 Me COOMe OMe OMe CH2460 Q.sub.74 Me COOEt Me OMe CH2461 Q.sub.74 Me COOEt OMe OMe CH2462 Q.sub.74 H H Me OMe CH2463 Q.sub.74 H H OMe OMe CH2464 Me H Q.sub.74 Me OMe CH2465 Me H Q.sub.74 OMe OMe CH2466 Q.sub.75 H COOMe Me OMe CH2467 Q.sub.75 H COOMe OMe OMe CH2468 Q.sub.75 H COOEt Me OMe CH2469 Q.sub.75 H COOEt OMe OMe CH2470 Q.sub.75 Me COOMe Me OMe CH2471 Q.sub.75 Me COOMe OMe OMe CH2472 Q.sub.75 Me COOEt Me OMe CH2473 Q.sub.75 Me COOEt OMe OMe CH2474 Q.sub.75 H H Me OMe CH2475 Q.sub.75 H H OMe OMe CH2476 Me H Q.sub.75 Me OMe CH2477 Me H Q.sub.75 OMe OMe CH2478 Q.sub.76 H COOMe Me OMe CH2479 Q.sub.76 H COOMe OMe OMe CH2480 Q.sub.76 H COOEt Me OMe CH2481 Q.sub.76 H COOEt OMe OMe CH2482 Q.sub.76 Me COOMe Me OMe CH2483 Q.sub.76 Me COOMe OMe OMe CH2484 Q.sub.76 Me COOEt Me OMe CH2485 Q.sub.76 Me COOEt OMe OMe CH2486 Q.sub.76 H H Me OMe CH2487 Q.sub.76 H H OMe OMe CH2488 Me H Q.sub. 76 Me OMe CH2489 Me H Q.sub.76 OMe OMe CH5347 Q.sub.10 Me COOMe Me Me CH5348 Q.sub.77 H COOMe Me OMe CH5349 Q.sub.77 H COOMe OMe OMe CH5350 Q.sub.77 H COOEt Me OMe CH5351 Q.sub.77 H COOEt OMe OMe CH5352 Q.sub.77 Me COOMe Me OMe CH5353 Q.sub.77 Me COOMe OMe OMe CH5354 Q.sub.77 Me COOEt Me OMe CH5355 Q.sub.77 Me COOEt OMe OMe CH5356 Q.sub.77 H H Me OMe CH5357 Q.sub.77 H H OMe OMe CH5358 Me H Q.sub.77 Me OMe CH5359 Me H Q.sub.77 OMe OMe CH5360 Q.sub.78 H COOMe Me Me CH5361 Q.sub.78 H COOMe Me OMe CH5362 Q.sub.78 H COOMe OMe OMe CH5363 Q.sub.78 H COOMe Me Me N5364 Q.sub.78 H COOMe Me OMe N5365 Q.sub.78 H COOMe OMe OMe N5366 Q.sub.78 H COOMe Me OCHF.sub.2 CH5367 Q.sub.78 H COOMe Cl OMe CH5368 Q.sub.78 H COOEt Me Me CH5369 Q.sub.78 H COOEt Me OMe CH5370 Q.sub.78 H COOEt OMe OMe CH5371 Q.sub.78 H COOEt Me Me N5372 Q.sub.78 H COOEt Me OMe N5373 Q.sub.78 H COOEt OMe OMe N5374 Q.sub.78 H COOEt Me OCHF.sub.2 CH5375 Q.sub.78 H COOEt Cl OMe CH5376 Q.sub.78 H COOPrn Me OMe CH5377 Q.sub.78 H COOPrn OMe OMe CH5378 Q.sub.78 H COOPrn Me OMe N5379 Q.sub.78 H COOPri Me OMe CH5380 Q.sub.78 H COOPri OMe OMe CH5381 Q.sub.78 H COOPri Me OMe N5382 Q.sub.78 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH5383 Q.sub.78 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH5384 Q.sub.78 H COOCH.sub.2 CH.sub.2 Cl Me OMe N5385 Q.sub.78 H COOCH.sub.2 CHCH.sub.2 Me OMe CH5386 Q.sub.78 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH5387 Q.sub.78 H COOCH.sub.2 CHCH.sub.2 Me OMe N5388 Q.sub.78 H COOCH.sub.2 CCH Me OMe CH5389 Q.sub.78 H COOCH.sub.2 C CH OMe OMe CH5390 Q.sub.78 H COOCH.sub.2 CCH Me OMe N5391 Q.sub.78 Me COOMe Me Me CH5392 Q.sub.78 Me COOMe Me OMe CH5393 Q.sub.78 Me COOMe OMe OMe CH5394 Q.sub.78 Me COOMe Me OMe N5395 Q.sub.78 Me COOMe OMe OMe N5396 Q.sub.78 Me COOEt Me Me CH5397 Q.sub.78 Me COOEt Me OMe CH5398 Q.sub.78 Me COOEt OMe OMe CH5399 Q.sub.78 Me COOEt Me OMe N5400 Q.sub.78 Me COOEt OMe OMe N5401 Q.sub.78 Cl COOMe Me OMe CH5402 Q.sub.78 Cl COOMe OMe OMe CH5403 Q.sub.78 Cl COOMe Me OMe N5404 Q.sub.78 Cl COOEt Me OMe CH5405 Q.sub.78 Cl COOEt OMe OMe CH5406 Q.sub.78 Cl COOEt Me OMe N5407 Q.sub.78 OMe COOMe Me OMe CH5408 Q.sub.78 OMe COOMe OMe OMe CH5409 Q.sub.78 OMe COOMe Me OMe N5410 Q.sub.78 OMe COOEt Me OMe CH5411 Q.sub.78 OMe COOEt OMe OMe CH5412 Q.sub.78 OMe COOEt Me OMe N5413 Q.sub.78 H Cl Me OMe CH5414 Q.sub.78 H Cl OMe OMe CH5415 Q.sub.78 H Cl Me OMe N5416 Q.sub.78 H NO.sub.2 Me OMe CH5417 Q.sub.78 H NO.sub.2 OMe OMe CH5418 Q.sub.78 H NO.sub.2 Me OMe N5419 Q.sub.78 H SO.sub.2 NMe.sub.2 Me OMe CH5420 Q.sub.78 H SO.sub.2 NMe.sub.2 OMe OMe CH5421 Q.sub.78 H SO.sub.2 NMe.sub.2 Me OMe N5422 Q.sub.78 H CN Me OMe CH5423 Q.sub.78 H CN OMe OMe CH5424 Q.sub.78 H CN Me OMe N5425 Q.sub.78 Me CN Me OMe CH5426 Q.sub.78 Me CN OMe OMe CH5427 Q.sub.78 Me CN Me OMe N5428 Q.sub.78 H Me Me OMe CH5429 Q.sub.78 H Me OMe OMe CH5430 Q.sub.78 H Me Me OMe N5431 Q.sub.78 H Et Me OMe CH5432 Q.sub.78 H Et OMe OMe CH5433 Q.sub.78 H Et Me OMe N5434 Q.sub.78 H H Me OMe CH5435 Q.sub.78 H H OMe OMe CH5436 Q.sub.78 H H Me OMe N5437 Q.sub.78 H COPh Me OMe CH5438 Q.sub.78 H COPh OMe OMe CH5439 Q.sub.78 H COPh Me OMe N5440 Me Q.sub.78 COOMe Me OMe CH5441 Me Q.sub.78 COOMe OMe OMe CH5442 Me Q.sub.78 COOMe Me OMe N5443 H H Q.sub.78 Me OMe CH5444 H H Q.sub.78 OMe OMe CH5445 H H Q.sub.78 Me OMe N5446 Me H Q.sub.78 Me Me CH5447 Me H Q.sub.78 Me OMe CH5448 Me H Q.sub.78 OMe OMe CH5449 Me H Q.sub.78 Me OMe N5450 Me H Q.sub.78 OMe OMe N5451 Me Me Q.sub.78 Me OMe CH5452 Me Me Q.sub.78 OMe OMe CH5453 Me Me Q.sub.78 Me OMe N5454 Q.sub.79 H COOMe Me Me CH5455 Q.sub.79 H COOMe Me OMe CH5456 Q.sub.79 H COOMe OMe OMe CH5457 Q.sub.79 H COOMe Me Me N5458 Q.sub.79 H COOMe Me OMe N5459 Q.sub.79 H COOMe OMe OMe N5460 Q.sub.79 H COOMe Me OCHF.sub.2 CH5461 Q.sub.79 H COOMe Cl OMe CH5462 Q.sub.79 H COOEt Me Me CH5463 Q.sub.79 H COOEt Me OMe CH5464 Q.sub.79 H COOEt OMe OMe CH5465 Q.sub.79 H COOEt Me Me N5466 Q.sub.79 H COOEt Me OMe N5467 Q.sub.79 H COOEt OMe OMe N5468 Q.sub.79 H COOEt Me OCHF.sub.2 CH5469 Q.sub.79 H COOEt Cl OMe CH5470 Q.sub.79 H COOPrn Me OMe CH5471 Q.sub.79 H COOPrn OMe OMe CH5472 Q.sub.79 H COOPrn Me OMe N5473 Q.sub.79 H COOPri Me OMe CH5474 Q.sub.79 H COOPri OMe OMe CH5475 Q.sub.79 H COOPri Me OMe N5476 Q.sub.79 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH5477 Q.sub.79 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH5478 Q.sub.79 H COOCH.sub.2 CH.sub.2 Cl Me OMe N5479 Q.sub.79 H COOCH.sub.2 CHCH.sub.2 Me OMe CH5480 Q.sub.79 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH5481 Q.sub.79 H COOCH.sub.2 CHCH.sub. 2 Me OMe N5482 Q.sub.79 H COOCH.sub.2 CCH Me OMe CH5483 Q.sub.79 H COOCH.sub.2 CCH OMe OMe CH5484 Q.sub.79 H COOCH.sub.2 CCH Me OMe N5485 Q.sub.79 Me COOMe Me Me CH5486 Q.sub.79 Me COOMe Me OMe CH5487 Q.sub.79 Me COOMe OMe OMe CH5488 Q.sub.79 Me COOMe Me OMe N5489 Q.sub.79 Me COOMe OMe OMe N5490 Q.sub.79 Me COOEt Me Me CH5491 Q.sub.79 Me COOEt Me OMe CH5492 Q.sub.79 Me COOEt OMe OMe CH5493 Q.sub.79 Me COOEt Me OMe N5494 Q.sub.79 Me COOEt OMe OMe N5495 Q.sub.79 Cl COOMe Me OMe CH5496 Q.sub.79 Cl COOMe OMe OMe CH5497 Q.sub.79 Cl COOMe Me OMe N5498 Q.sub.79 Cl COOEt Me OMe CH5499 Q.sub.79 Cl COOEt OMe OMe CH5500 Q.sub.79 Cl COOEt Me OMe N5501 Q.sub.79 OMe COOMe Me OMe CH5502 Q.sub.79 OMe COOMe OMe OMe CH5503 Q.sub.79 OMe COOMe Me OMe N5504 Q.sub.79 OMe COOEt Me OMe CH5505 Q.sub.79 OMe COOEt OMe OMe CH5506 Q.sub.79 OMe COOEt Me OMe N5507 Q.sub.79 H Cl Me OMe CH5508 Q.sub.79 H Cl OMe OMe CH5509 Q.sub.79 H Cl Me OMe N5510 Q.sub.79 H NO.sub.2 Me OMe CH5511 Q.sub.79 H NO.sub.2 OMe OMe CH5512 Q.sub.79 H NO.sub.2 Me OMe N5513 Q.sub.79 H SO.sub.2 NMe.sub.2 Me OMe CH5514 Q.sub.79 H SO.sub.2 NMe.sub.2 OMe OMe CH5515 Q.sub.79 H SO.sub.2 NMe.sub.2 Me OMe N5516 Q.sub.79 H CN Me OMe CH5517 Q.sub.79 H CN OMe OMe CH5518 Q.sub.79 H CN Me OMe N5519 Q.sub.79 Me CN Me OMe CH5520 Q.sub.79 Me CN OMe OMe CH5521 Q.sub.79 Me CN Me OMe N5522 Q.sub.79 H Me Me OMe CH5523 Q.sub.79 H Me OMe OMe CH5524 Q.sub.79 H Me Me OMe N5525 Q.sub.79 H Et Me OMe CH5526 Q.sub.79 H Et OMe OMe CH5527 Q.sub.79 H Et Me OMe N5528 Q.sub.79 H H Me OMe CH5529 Q.sub.79 H H OMe OMe CH5530 Q.sub.79 H H Me OMe N5531 Q.sub.79 H COPh Me OMe CH5532 Q.sub.79 H COPh OMe OMe CH5533 Q.sub.79 H COPh Me OMe N5534 Me Q.sub.79 COOMe Me OMe CH5535 Me Q.sub.79 COOMe OMe OMe CH5536 Me Q.sub.79 COOMe Me OMe N5537 H H Q.sub.79 Me OMe CH5538 H H Q.sub.79 OMe OMe CH5539 H H Q.sub.79 Me OMe N5540 Me H Q.sub.79 Me Me CH5541 Me H Q.sub.79 Me OMe CH5542 Me H Q.sub.79 OMe OMe CH5543 Me H Q.sub.79 Me OMe N5544 Me H Q.sub.79 OMe OMe N5545 Me Me Q.sub.79 Me OMe CH5546 Me Me Q.sub.79 OMe OMe CH5547 Me Me Q.sub.79 Me OMe N5548 Q.sub.80 H COOMe Me Me CH5549 Q.sub.80 H COOMe Me OMe CH5550 Q.sub.80 H COOMe OMe OMe CH5551 Q.sub.80 H COOMe Me OMe N5552 Q.sub.80 H COOMe OMe OMe N5553 Q.sub.80 H COOEt Me Me CH5554 Q.sub.80 H COOEt Me OMe CH5555 Q.sub.80 H COOEt OMe OMe CH5556 Q.sub.80 H COOEt Me OMe N5557 Q.sub.80 H COOEt OMe OMe N5558 Q.sub.80 Me COOMe Me OMe CH5559 Q.sub.80 Me COOMe OMe OMe CH5560 Q.sub.80 Me COOMe Me OMe N5561 Q.sub.80 Me COOEt Me OMe CH5562 Q.sub.80 Me COOEt OMe OMe CH5563 Q.sub.80 Me COOEt Me OMe N5564 Q.sub.80 H CN Me OMe CH5565 Q.sub.80 H CN OMe OMe CH5566 Q.sub.80 H CN Me OMe N5567 Q.sub.80 H H Me OMe CH5568 Q.sub.80 H H OMe OMe CH5569 Q.sub.80 H H Me OMe N5570 Me H Q.sub.80 Me Me CH5571 Me H Q.sub.80 Me OMe CH5572 Me H Q.sub.80 OMe OMe CH5573 Me H Q.sub.80 Me OMe N5574 Me H Q.sub.80 OMe OMe N5575 Q.sub.81 H COOMe Me OMe CH5576 Q.sub.81 H COOMe OMe OMe CH5577 Q.sub.81 H COOEt Me OMe CH5578 Q.sub.81 H COOEt OMe OMe CH5579 Q.sub.81 Me COOMe Me OMe CH5580 Q.sub.81 Me COOMe OMe OMe CH5581 Q.sub.81 Me COOEt Me OMe CH5582 Q.sub.81 Me COOEt OMe OMe CH5583 Q.sub.81 H H Me OMe CH5584 Q.sub.81 H H OMe OMe CH5585 Me H Q.sub.81 Me OMe CH5586 Me H Q.sub.81 OMe OMe CH5587 Q.sub.82 H COOMe Me OMe CH5588 Q.sub.82 H COOMe OMe OMe CH5589 Q.sub.82 H COOEt Me OMe CH5590 Q.sub.82 H COOEt OMe OMe CH5591 Q.sub.82 Me COOMe Me OMe CH5592 Q.sub.82 Me COOMe OMe OMe CH5593 Q.sub.82 Me COOEt Me OMe CH5594 Q.sub.82 Me COOEt OMe OMe CH5595 Q.sub.82 H H Me OMe CH5596 Q.sub.82 H H OMe OMe CH5597 Me H Q.sub.82 Me OMe CH5598 Me H Q.sub.82 OMe OMe CH5599 Q.sub.83 H COOMe Me OMe CH5600 Q.sub.83 H COOMe OMe OMe CH5601 Q.sub.83 H COOEt Me OMe CH5602 Q.sub.83 H COOEt OMe OMe CH5603 Q.sub.83 Me COOMe Me OMe CH5604 Q.sub.83 Me COOMe OMe OMe CH5605 Q.sub.83 Me COOEt Me OMe CH5606 Q.sub.83 Me COOEt OMe OMe CH5607 Q.sub.83 H H Me OMe CH5608 Q.sub.83 H H OMe OMe CH5609 Me H Q.sub.83 Me OMe CH5610 Me H Q.sub.83 OMe OMe CH__________________________________________________________________________
In the above, Q.sub.1 to Q.sub.83 each represent the following heterocyclic group. ##STR19##
TABLE 2__________________________________________________________________________No. A B D X Y Z__________________________________________________________________________2490 Q.sub.1 H H Me Me CH2491 Q.sub.1 H H Me OMe CH2492 Q.sub.1 H H OMe OMe CH2493 Q.sub.1 H H Me OMe N2494 Q.sub.1 H H OMe OMe N2495 Q.sub.1 Me H Me Me CH2496 Q.sub.1 Me H Me OMe CH2497 Q.sub.1 Me H OMe OMe CH2498 Q.sub.1 Me H Me OMe N2499 Q.sub.1 Me H OMe OMe N2500 Q.sub.1 H Me Me Me CH2501 Q.sub.1 H Me Me OMe CH2502 Q.sub.1 H Me OMe OMe CH2503 Q.sub.1 H Me Me OMe N2504 Q.sub.1 H Me OMe OMe N2505 Q.sub.1 Me Cl Me Me CH2506 Q.sub.1 Me Cl Me OMe CH2507 Q.sub.1 Me Cl OMe OMe CH2508 Q.sub.1 Me Cl Me OMe N2509 Q.sub.1 Me Cl OMe OMe N2510 Q.sub.1 Me OMe Me Me CH2511 Q.sub.1 Me OMe Me OMe CH2512 Q.sub.1 Me OMe OMe OMe CH2513 Q.sub.1 Me OMe Me OMe N2514 Q.sub.1 Me OMe OMe OMe N2515 Q.sub.1 Cl H Me Me CH2516 Q.sub.1 Cl H Me OMe CH2517 Q.sub.1 Cl H OMe OMe CH2518 Q.sub.1 Cl H Me OMe N2519 Q.sub.1 Cl H OMe OMe N2520 Q.sub.1 Br H Me Me CH2521 Q.sub.1 Br H Me OMe CH2522 Q.sub.1 Br H OMe OMe N2523 Q.sub.1 CF.sub.3 H Me OMe CH2524 Q.sub.1 CF.sub.3 H OMe OMe CH2525 Q.sub.1 CF.sub.3 H Me Me CH2526 Q.sub.1 CF.sub.3 H Me OMe N2527 Q.sub.1 CF.sub.3 H OMe OMe N2528 Q.sub. 1 H CF.sub.3 Me OMe CH2529 Q.sub.1 H CF.sub.3 OMe OMe CH2530 Q.sub.1 H CF.sub.3 OMe OMe CH2531 Q.sub.1 H CF.sub.3 Me OMe N2532 Q.sub.1 H CF.sub.3 OMe OMe N2533 Q.sub.1 CF.sub.3 CH.sub.3 Me Me CH2534 Q.sub.1 CF.sub.3 CH.sub.3 Me OMe CH2535 Q.sub.1 CF.sub.3 CH.sub.3 OMe OMe CH2536 Q.sub.1 CF.sub.3 CH.sub.3 Me OMe N2537 Q.sub.1 CF.sub.3 CH.sub.3 OMe OMe N2538 Q.sub.1 CH.sub.3 CF.sub.3 Me Me CH2539 Q.sub.1 CH.sub.3 CF.sub.3 Me OMe CH2540 Q.sub.1 CH.sub.3 CF.sub.3 OMe OMe CH2541 Q.sub.1 CH.sub.3 CF.sub.3 Me OMe N2542 Q.sub.1 CH.sub.3 CF.sub.3 OMe OMe N2543 Q.sub.1 H COOMe Me Me CH2544 Q.sub.1 H COOMe Me OMe CH2545 Q.sub.1 H COOMe OMe OMe CH2546 Q.sub.1 H COOMe Me OMe N2547 Q.sub.1 H COOMe OMe OMe N2548 Q.sub.1 Me COOMe Me Me CH2549 Q.sub.1 Me COOMe Me OMe CH2550 Q.sub.1 Me COOMe OMe OMe CH2551 Q.sub.1 Me COOMe Me OMe N2552 Q.sub.1 Me COOMe OMe OMe N2553 Q.sub.1 Me COOMe Me Cl CH2554 Q.sub.1 Me COOMe Me CH.sub.2 OMe CH2555 Q.sub.1 Me COOMe Me OCHF.sub.2 CH2556 Q.sub.1 Me COOMe Me ##STR20## CH2557 Q.sub.1 Me COOMe OMe OMe CCl2558 Q.sub.1 Me COOMe Me NMe.sub.2 N2559 Q.sub.1 Me COOMe Me Me N2560 Q.sub.1 Me COOH Me Me CH2561 Q.sub.1 Me COOH Me OMe CH2562 Q.sub.1 Me COOH OMe OMe CH2563 Q.sub.1 Me COOH Me OMe N2564 Q.sub.1 Me COOH OMe OMe N2565 Q.sub.1 Me COOEt Me Me CH2566 Q.sub.1 Me COOEt Me OMe CH2567 Q.sub.1 Me COOEt OMe OMe CH2568 Q.sub.1 Me COOEt Me OMe N2569 Q.sub.1 Me COOEt OMe OMe N2570 Q.sub.1 Me COOPrn Me Me CH2571 Q.sub.1 Me COOPrn Me OMe CH2572 Q.sub.1 Me COOPrn OMe OMe CH2573 Q.sub.1 Me COOPrn Me OMe N2574 Q.sub.1 Me COOPrn OMe OMe N2575 Q.sub.1 Me COOPri Me Me CH2576 Q.sub.1 Me COOPri Me OMe CH2577 Q.sub.1 Me COOPri OMe OMe CH2578 Q.sub.1 Me COOPri Me OMe N2579 Q.sub.1 Me COOPri OMe OMe N2580 Q.sub.1 Me COOCH.sub.2 CHCH.sub.2 Me Me CH2581 Q.sub.1 Me COOCH.sub.2 CHCH.sub.2 Me OMe CH2582 Q.sub.1 Me COOCH.sub.2 CHCH.sub.2 OMe OMe CH2583 Q.sub.1 Me COOCH.sub.2 CHCH.sub.2 Me OMe N2584 Q.sub.1 Me COOCH.sub.2 CHCH.sub.2 OMe OMe N2585 Q.sub.1 Me COOCH.sub.2 CCH Me Me CH2586 Q.sub.1 Me COOCH.sub.2 CCH Me OMe CH2587 Q.sub.1 Me COOCH.sub.2 CCH OMe OMe CH2588 Q.sub.1 Me COOCH.sub.2 CCH Me OMe N2589 Q.sub.1 Me COOCH.sub.2 CCH OMe OMe N2590 Q.sub.1 Cl COOMe Me OMe CH2591 Q.sub.1 Cl COOMe OMe OMe CH2592 Q.sub.1 Cl COOMe Me OMe N2593 Q.sub.1 Et COOMe Me OMe CH2594 Q.sub.1 Et COOMe OMe OMe CH2595 Q.sub.1 Et COOMe Me OMe N2596 Q.sub.1 Me CONMe.sub.2 Me OMe CH2597 Q.sub.1 Me CONMe.sub.2 OMe OMe CH2598 Q.sub.1 Me CONMe.sub.2 Me OMe N2599 Q.sub.1 Me SMe Me OMe CH2600 Q.sub.1 Me SMe OMe OMe CH2601 Q.sub.1 Me SMe Me OMe N2602 Q.sub.1 Me SOMe Me OMe CH2603 Q.sub.1 Me SOMe OMe OMe CH2604 Q.sub.1 Me SOMe Me OMe N2605 Q.sub.1 Me SO.sub.2 Me Me OMe CH2606 Q.sub.1 Me SO.sub.2 Me OMe OMe CH2607 Q.sub.1 Me SO.sub.2 Me Me OMe N2608 Q.sub.1 Me SO.sub.2 Et Me OMe CH2609 Q.sub.1 Me SO.sub.2 Et OMe OMe CH2610 Q.sub.1 Me SO.sub.2 Et Me OMe N2611 Q.sub.1 Me SO.sub.2 Prn Me Me CH2612 Q.sub.1 Me SO.sub.2 Prn Me OMe CH2613 Q.sub.1 Me SO.sub.2 Prn OMe OMe CH2614 Q.sub.1 Me SO.sub.2 Prn Me OMe N2615 Q.sub.1 Me SO.sub.2 Prn OMe OMe N2616 Q.sub.1 Me SO.sub.2 Ph Me OMe CH2617 Q.sub.1 Me SO.sub.2 Ph OMe OMe CH2618 Q.sub.1 Me SO.sub.2 Ph Me OMe N2619 Q.sub.1 Me SO.sub.2 CH.sub.2 CF.sub.3 Me OMe CH2620 Q.sub.1 Me SO.sub.2 CH.sub.2 CF.sub.3 OMe OMe CH2621 Q.sub.1 Me SO.sub.2 CH.sub.2 CF.sub.3 Me OMe N2622 Q.sub.1 Me SO.sub.3 CH.sub.3 Me OMe CH2623 Q.sub.1 Me SO.sub.3 CH.sub.3 OMe OMe CH2624 Q.sub.1 Me SO.sub.3 CH.sub.3 Me OMe N2625 Q.sub.1 Me SO.sub.3 CH.sub.2 CHCH.sub.2 Me OMe CH2626 Q.sub.1 Me SO.sub.3 CH.sub.2 CHCH.sub.2 OMe OMe CH2627 Q.sub.1 Me SO.sub.3 CH.sub.2 CHCH.sub.2 Me OMe N2628 Q.sub.1 Me SO.sub.3 CH.sub.2 CCH Me OMe CH2629 Q.sub.1 Me SO.sub.3 CH.sub.2 CCH OMe OMe CH2630 Q.sub.1 Me SO.sub.3 CH.sub.2 C CH Me OMe N2631 Q.sub.1 Me SO.sub.3 CH.sub.2 CCH Me OMe CH2632 Q.sub.1 Me SO.sub.2 NMe.sub.2 OMe OMe CH2633 Q.sub.1 Me SO.sub.2 NMe.sub.2 Me OMe N2634 Q.sub.1 Me CN Me OMe CH2635 Q.sub.1 Me CN OMe OMe CH2636 Q.sub.1 Me CN Me OMe N2637 Q.sub.1 Me OH Me OMe CH2638 Q.sub.1 Me OH OMe OMe CH2639 Q.sub.1 Me OH Me OMe N2640 Q.sub.1 Ph COOMe Me Me CH2641 Q.sub.1 Ph COOMe Me OMe CH2642 Q.sub.1 Ph COOMe OMe OMe CH2643 Q.sub.1 Ph COOMe Me OMe N2644 Q.sub.1 Ph COOMe OMe OMe N2645 Q.sub.1 Me Ph Me OMe CH2646 Q.sub.1 Me Ph OMe OMe CH2647 Q.sub.1 Me Ph Me OMe N2648 Q.sub.1 COOMe Me Me Me CH2649 Q.sub.1 COOMe Me Me OMe CH2650 Q.sub.1 COOMe Me OMe OMe CH2651 Q.sub.1 COOMe Me Me OMe N2652 Q.sub. 1 COOMe Me OMe OMe N2653 H Q.sub.1 Me Me Me CH2654 H Q.sub.1 Me Me OMe CH2655 H Q.sub.1 Me OMe OMe CH2656 H Q.sub.1 Me Me OMe N2657 H Q.sub.1 Me OMe OMe N2658 H Q.sub.1 Cl Me Me CH2659 H Q.sub.1 Cl Me OMe CH2660 H Q.sub.1 Cl OMe OMe CH2661 H Q.sub.1 Cl Me OMe N2662 H Q.sub.1 Cl OMe OMe N2663 H Q.sub.1 OMe Me Me CH2664 H Q.sub.1 OMe Me OMe CH2665 H Q.sub.1 OMe OMe OMe CH2666 H Q.sub.1 OMe Me OMe N2667 H Q.sub.1 OMe OMe OMe N2668 H Q.sub.1 COOMe Me Me CH2669 H Q.sub.1 COOMe Me OMe CH2670 H Q.sub.1 COOMe OMe OMe CH2671 H Q.sub.1 COOMe Me OMe N2672 H Q.sub.1 COOMe OMe OMe N2673 H Q.sub.1 SO.sub.2 Me Me Me CH2674 H Q.sub.1 SO.sub.2 Me Me OMe CH2675 H Q.sub.1 SO.sub.2 Me OMe OMe CH2676 H Q.sub.1 SO.sub.2 Me Me OMe N2677 H Q.sub.1 SO.sub.2 Me OMe OMe N2678 Me Q.sub.1 Me Me Me CH2679 Me Q.sub.1 Me Me OMe CH2680 Me Q.sub.1 Me OMe OMe CH2681 Me Q.sub.1 Me Me OMe N2682 Me Q.sub.1 Me OMe OMe N2683 Me Q.sub.1 Cl Me Me CH2684 Me Q.sub.1 Cl Me OMe CH2685 Me Q.sub.1 Cl OMe OMe CH2686 Me Q.sub.1 Cl Me OMe N2687 Me Q.sub.1 Cl OMe OMe N2688 Me Q.sub.1 OMe Me Me CH2689 Me Q.sub.1 OMe Me OMe CH2690 Me Q.sub.1 OMe OMe OMe CH2691 Me Q.sub.1 OMe Me OMe N2692 Me Q.sub.1 OMe OMe OMe N2693 Me Q.sub.1 COOMe Me Me CH2694 Me Q.sub.1 COOMe Me OMe CH2695 Me Q.sub.1 COOMe OMe OMe CH2696 Me Q.sub.1 COOMe Me OMe N2697 Me Q.sub.1 COOMe OMe OMe N2698 Me Q.sub.1 COOEt Me OMe CH2699 Me Q.sub.1 COOEt OMe OMe CH2700 Me Q.sub.1 COOEt Me OMe N2701 Me Q.sub.1 SMe Me OMe CH2702 Me Q.sub.1 SMe OMe OMe CH2703 Me Q.sub.1 SMe Me OMe N2704 Me Q.sub.1 SO.sub.2 Me Me OMe CH2705 Me Q.sub.1 SO.sub.2 Me OMe OMe CH2706 Me Q.sub.1 SO.sub.2 Me Me OMe N2707 Me Q.sub.1 SO.sub.2 Et Me OMe CH2708 Me Q.sub.1 SO.sub.2 Et OMe OMe CH2709 Me Q.sub.1 SO.sub.2 Et Me OMe N2710 Me Q.sub.1 SO.sub.2 Prn Me OMe CH2711 Me Q.sub.1 SO.sub.2 Prn OMe OMe CH2712 Me Q.sub.1 SO.sub.2 Prn Me OMe N2713 Me Q.sub.1 SO.sub.2 Pri Me OMe CH2714 Me Q.sub.1 SO.sub.2 Pri OMe OMe CH2715 Me Q.sub.1 SO.sub.2 Pri Me OMe N2716 Me Q.sub.1 Br Me Me CH2717 Me Q.sub.1 Br Me OMe CH2718 Me Q.sub.1 Br OMe OMe CH2719 Me Q.sub.1 Br Me OMe N2720 Me Q.sub.1 Br OMe OMe N2721 Me Q.sub.1 SO.sub.2 NMe.sub.2 Me Me CH2722 Me Q.sub.1 SO.sub.2 NMe.sub.2 Me OMe CH2723 Me Q.sub.1 SO.sub.2 NMe.sub.2 OMe OMe CH2724 Me Q.sub.1 SO.sub.2 NMe.sub.2 Me OMe N2725 Me Q.sub.1 SO.sub.2 NMe.sub.2 OMe OMe N2726 Me Q.sub.1 Ph Me Me CH2727 Me Q.sub.1 Ph Me OMe CH2728 Me Q.sub.1 Ph OMe OMe CH2729 Me Q.sub.1 Ph Me OMe N2730 Me Q.sub.1 Ph OMe OMe N2731 Me Q.sub.1 Ph2-Cl Me OMe CH2732 Me Q.sub.1 Ph2-Cl OMe OMe CH2733 Me Q.sub.1 Ph2-Cl Me OMe N2734 Me Q.sub.1 Ph2-Me Me OMe CH2735 Me Q.sub.1 Ph2-Me OMe OMe CH2736 Me Q.sub.1 Ph2-Me Me OMe N2737 Me Q.sub.1 Ph2-NO.sub.2 Me OMe CH2738 Me Q.sub.1 Ph2-NO.sub.2 OMe OMe CH2739 Me Q.sub.1 Ph2-NO.sub.2 Me OMe N2740 Me Q.sub.1 Ph4-Cl Me OMe CH2741 Me Q.sub.1 Ph4-Cl OMe OMe CH2742 Me Q.sub.1 Ph4-Cl Me OMe N2743 Et Q.sub.1 Me Me OMe CH2744 Et Q.sub.1 Me OMe OMe CH2745 Et Q.sub.1 Me Me OMe N2746 CH.sub.2 CHCH.sub.2 Q.sub.1 Me Me OMe CH2747 CH.sub.2 CHCH.sub.2 Q.sub.1 Me OMe OMe CH2748 CH.sub.2 CHCH.sub.2 Q.sub.1 Me Me OMe N2749 CH.sub.2 CCH Q.sub.1 Me Me OMe CH2750 CH.sub.2 CCH Q.sub.1 Me OMe OMe CH2751 CH.sub.2 CCH Q.sub.1 Me Me OMe N2752 CH.sub.2 CN Q.sub.1 Me Me OMe CH2753 CH.sub.2 CN Q.sub.1 Me OMe OMe CH2754 CH.sub.2 CN Q.sub.1 Me Me OMe N2755 CH.sub.2 OMe Q.sub.1 Me Me OMe CH2756 CH.sub.2 OMe Q.sub.1 Me OMe OMe CH2757 CH.sub.2 OMe Q.sub.1 Me Me OMe N2758 Ph Q.sub.1 Me Me OME CH2759 Ph Q.sub.1 Me OMe OMe CH2760 Ph Q.sub.1 Me Me OMe N2761 Me Me Q.sub.1 Me Me CH2762 Me Me Q.sub.1 Me OMe CH2763 Me Me Q.sub.1 OMe OMe CH2764 Me Me Q.sub.1 Me OMe N2765 Me Me Q.sub.1 OMe OMe N2766 Me Cl Q.sub.1 Me Me CH2767 Me Cl Q.sub.1 Me OMe CH2768 Me Cl Q.sub.1 OMe OMe CH2769 Me Cl Q.sub.1 Me OMe N2770 Me Cl Q.sub.1 OMe OMe N2771 Me OMe Q.sub.1 Me OMe CH2772 Me OMe Q.sub.1 OMe OMe CH2773 Me OMe Q.sub.1 Me OMe N2774 Me COOMe Q.sub.1 Me Me CH2775 Me COOMe Q.sub.1 Me OMe CH2776 Me COOMe Q.sub.1 OMe OMe CH2777 Me COOMe Q.sub.1 Me OMe N2778 Me COOMe Q.sub.1 OMe OMe N2779 Me SMe Q.sub.1 Me OMe CH2780 Me SMe Q.sub.1 OMe OMe CH2781 Me SMe Q.sub.1 Me OMe N2782 Me SO.sub.2 Me Q.sub.1 Me OMe CH2783 Me SO.sub.2 Me Q.sub.1 OMe OMe CH2784 Me SO.sub.2 Me Q.sub.1 Me OMe N2785 Me Ph Q.sub.1 Me Me CH2786 Me Ph Q.sub.1 Me OMe CH2787 Me Ph Q.sub.1 OMe OMe CH2788 Me Ph Q.sub.1 Me OMe N2789 Me Ph Q.sub.1 OMe OMe N2790 Me Ph2-Cl Q.sub.1 Me OMe CH2791 Me Ph2-Cl Q.sub.1 OMe OMe CH2792 Me Ph2-Cl Q.sub.1 Me OMe N2793 Ph Me Q.sub.1 Me OMe CH2794 Ph Me Q.sub.1 OMe OMe CH2795 Ph Me Q.sub.1 Me OMe N2796 Q.sub.2 Me Cl Me Me CH2797 Q.sub.2 Me Cl Me OMe CH2798 Q.sub.2 Me Cl OMe OMe CH2799 Q.sub.2 Me Cl Me OMe N2800 Q.sub.2 Me Cl OMe OMe N2801 Q.sub.2 Me OMe Me OMe CH2802 Q.sub.2 Me OMe OMe OMe CH2803 Q.sub.2 Me OMe Me OMe N2804 Q.sub.2 CF.sub.3 Me Me OMe CH2805 Q.sub.2 CF.sub.3 Me OMe OMe CH2806 Q.sub.2 CF.sub.3 Me Me OMe N2807 Q.sub.2 Me COOMe Me Me CH2808 Q.sub.2 Me COOMe Me OMe CH2809 Q.sub.2 Me COOMe OMe OMe CH2810 Q.sub.2 Me COOMe Me OMe N2811 Q.sub.2 Me COOMe OMe OMe N2812 Q.sub.2 Me COOMe Me OCHF.sub.2 CH2813 Q.sub.2 Me COOMe Me ##STR21## CH2814 Q.sub.2 Me SO.sub.2 Me Me OMe CH2815 Q.sub.2 Me SO.sub.2 Me OMe OMe CH2816 Q.sub.2 Me SO.sub.2 Me Me OMe N2817 H Q.sub.2 Me Me OMe CH2818 H Q.sub.2 Me OMe OMe CH2819 H Q.sub.2 Me Me OMe N2820 Me Q.sub.2 Me Me OMe CH2821 Me Q.sub.2 Me OMe OMe CH2822 Me Q.sub.2 Me Me OMe N2823 Me Q.sub.2 Cl Me OMe CH2824 Me Q.sub.2 Cl OMe OMe CH2825 Me Q.sub.2 Cl Me OMe N2826 Me Q.sub.2 COOMe Me OMe CH2827 Me Q.sub.2 COOMe OMe OMe CH2828 Me Q.sub.2 COOMe Me OMe N2829 Me Q.sub.2 Ph Me OMe CH2830 Me Q.sub.2 Ph OMe OMe CH2831 Me Q.sub.2 Ph Me OMe N2832 Me Me Q.sub.2 Me OMe CH2833 Me Me Q.sub.2 OMe OMe CH2834 Me Me Q.sub.2 Me OMe N2835 Q.sub.3 Me COOMe Me Me CH2836 Q.sub.3 Me COOMe Me OMe CH2837 Q.sub.3 Me COOMe OMe OMe CH2838 Q.sub.3 Me COOMe Me OMe N2839 Q.sub.3 Me COOMe OMe OMe N2840 Me Q.sub.3 Me Me OMe CH2841 Me Q.sub.3 Me OMe OMe CH2842 Me Q.sub.3 Me Me OMe N2843 Me Me Q.sub.3 Me OMe CH2844 Me Me Q.sub.3 OMe OMe CH2845 Me Me Q.sub.3 Me OMe N2846 Q.sub.4 Me COOMe Me Me CH2847 Q.sub.4 Me COOMe Me OMe CH2848 Q.sub.4 Me COOMe OMe OMe CH2849 Q.sub.4 Me COOMe Me OMe N2850 Q.sub.4 Me COOMe OMe OMe N2851 Me Q.sub.4 Me Me OMe CH2852 Me Q.sub.4 Me OMe OMe CH2853 Me Q.sub.4 Me Me OMe N2854 Me Me Q.sub.4 OMe OMe CH2855 Me Me Q.sub.4 Me OMe CH2856 Me Me Q.sub.4 Me OMe N2857 Q.sub.5 Me Cl Me Me CH2858 Q.sub.5 Me Cl Me OMe CH2859 Q.sub.5 Me Cl OMe OMe CH2860 Q.sub.5 Me Cl Me OMe N2861 Q.sub.5 Me Cl OMe OMe N2862 Q.sub.5 Me OMe Me OMe CH2863 Q.sub.5 Me OMe OMe OMe CH2864 Q.sub.5 Me OMe Me OMe N2865 Q.sub.5 CF.sub.3 Me Me OMe CH2866 Q.sub.5 CF.sub.3 Me OMe OMe CH2867 Q.sub.5 CF.sub.3 Me Me OMe N2868 Q.sub.5 Me COOMe Me Me CH2869 Q.sub.5 Me COOMe Me OMe CH2870 Q.sub.5 Me COOMe OMe OMe CH2871 Q.sub.5 Me COOMe Me OMe N2872 Q.sub.5 Me COOMe OMe OMe N2873 Q.sub.5 Me COOMe Me OCHF.sub.2 CH2874 Q.sub.5 Me COOMe Me ##STR22## CH2875 Q.sub.5 Me SO.sub.2 Me Me OMe CH2876 Q.sub.5 Me SO.sub.2 Me OMe OMe CH2877 Q.sub.5 Me SO.sub.2 Me Me OMe N2878 H Q.sub.5 Me Me OMe CH2879 H Q.sub.5 Me OMe OMe CH2880 H Q.sub.5 Me Me OMe N2881 Me Q.sub.5 Me Me OMe CH2882 Me Q.sub.5 Me OMe OMe CH2883 Me Q.sub.5 Me Me OMe N2884 Me Q.sub.5 Cl Me OMe CH2885 Me Q.sub.5 Cl OMe OMe CH2886 Me Q.sub.5 Cl Me OMe N2887 Me Q.sub.5 COOMe Me OMe CH2888 Me Q.sub.5 COOMe OMe OMe CH2889 Me Q.sub.5 COOMe Me OMe N2890 Me Q.sub.5 Ph Me OMe CH2891 Me Q.sub.5 Ph OMe OMe CH2892 Me Q.sub.5 Ph Me OMe N2893 Me Me Q.sub.5 Me OMe CH2894 Me Me Q.sub.5 OMe OMe CH2895 Me Me Q.sub.5 Me OMe N2896 Q.sub.6 Me COOMe Me Me CH2897 Q.sub.6 Me COOMe Me OMe CH2898 Q.sub.6 Me COOMe OMe OMe CH2899 Q.sub.6 Me COOMe Me OMe N2900 Q.sub.6 Me COOMe OMe OMe N2901 Me Q.sub.6 Me Me OMe CH2902 Me Q.sub.6 Me OMe OMe CH2903 Me Q.sub.6 Me Me OMe N2904 Me Me Q.sub.6 Me OMe CH2905 Me Me Q.sub.6 OMe OMe CH2906 Me Me Q.sub.6 Me OMe N2907 Q.sub.7 Me COOMe Me OMe CH2908 Q.sub.7 Me COOMe OMe OMe CH2909 Q.sub.7 Me COOMe Me OMe N2910 Me Me Q.sub.7 OMe OMe CH2911 Me Me Q.sub.7 Me OMe N2912 Q.sub.8 Me Cl Me Me CH2913 Q.sub.8 Me Cl Me OMe CH2914 Q.sub.8 Me Cl OMe OMe CH2915 Q.sub.8 Me Cl Me OMe N2916 Q.sub.8 Me Cl OMe OMe N2917 Q.sub.8 Me OMe Me OMe CH2918 Q.sub.8 Me OMe OMe OMe CH2919 Q.sub.8 Me OMe Me OMe N2920 Q.sub.8 CF.sub.3 Me Me OMe CH2921 Q.sub.8 CF.sub.3 Me OMe OMe CH2922 Q.sub.8 CF.sub.3 Me Me OMe N2923 Q.sub.8 Me COOMe Me Me CH2924 Q.sub.8 Me COOMe Me OMe CH2925 Q.sub.8 Me COOMe OMe OMe CH2926 Q.sub.8 Me COOMe Me OMe N2927 Q.sub.8 Me COOMe OMe OMe N2928 Q.sub.8 Me COOMe Me OCHF.sub.2 CH2929 Q.sub.8 Me COOMe Me ##STR23## CH2930 Q.sub.8 Me SO.sub.2 Me Me OMe CH2931 Q.sub.8 Me SO.sub.2 Me OMe OMe CH2932 Q.sub.8 Me SO.sub.2 Me Me OMe N2933 H Q.sub.8 Me Me OMe CH2934 H Q.sub.8 Me OMe OMe CH2935 H Q.sub.8 Me Me OMe N2936 Me Q.sub.8 Me Me OMe CH2937 Me Q.sub.8 Me OMe OMe CH2938 Me Q.sub.8 Me Me OMe N2939 Me Q.sub.8 Cl Me OMe CH2940 Me Q.sub.8 Cl OMe OMe CH2941 Me Q.sub.8 Cl Me OMe N2942 Me Q.sub.8 COOMe Me OMe CH2943 Me Q.sub.8 COOMe OMe OMe CH2944 Me Q.sub.8 COOMe Me OMe N2945 Me Q.sub.8 Ph Me OMe CH2946 Me Q.sub.8 Ph OMe OMe CH2947 Me Q.sub.8 Ph Me OMe N2948 Me Me Q.sub.8 Me OMe CH2949 Me Me Q.sub.8 OMe OMe CH2950 Me Me Q.sub.8 Me OMe N2951 Q.sub.9 Me COOMe Me Me CH2952 Q.sub.9 Me COOMe Me OMe CH2953 Q.sub.9 Me COOMe OMe OMe CH2954 Q.sub.9 Me COOMe Me OMe N2955 Q.sub.9 Me COOMe OMe OMe N2956 Me Q.sub.9 Me Me OMe CH2957 Me Q.sub.9 Me OMe OMe CH2958 Me Q.sub.9 Me Me OMe N2959 Me Me Q.sub.9 Me OMe CH2960 Me Me Q.sub.9 OMe OMe CH2961 Me Me Q.sub.9 Me OMe N2962 Q.sub.10 Me COOMe Me Me CH2963 Q.sub.10 Me COOMe Me OMe CH2964 Q.sub.10 Me COOMe OMe OMe CH2965 Q.sub.10 Me COOMe Me OMe N2966 Q.sub.10 Me COOMe OMe OMe N2967 Me Q.sub.10 Me Me OMe CH2968 Me Q.sub.10 Me OMe OMe CH2969 Me Q.sub.10 Me Me OMe N2970 Me Me Q.sub.10 Me OMe CH2971 Me Me Q.sub.10 OMe OMe CH2972 Me Me Q.sub.10 Me OMe N2973 Q.sub.11 Me COOMe Me Me CH2974 Q.sub.11 Me COOMe Me OMe CH2975 Q.sub.11 Me COOMe OMe OMe CH2976 Q.sub.11 Me COOMe Me OMe N2977 Q.sub.11 Me COOMe OMe OMe N2978 Me Q.sub. 11 Me Me OMe CH2979 Me Q.sub.11 Me OMe OMe CH2980 Me Q.sub.11 Me Me OMe N2981 Me Me Q.sub.11 Me OMe CH2982 Me Me Q.sub.11 OMe OMe CH2983 Me Me Q.sub.11 Me OMe N2984 Q.sub.12 Me COOMe Me Me CH2985 Q.sub.12 Me COOMe Me OMe CH2986 Q.sub.12 Me COOMe OMe OMe CH2987 Q.sub.12 Me COOMe Me OMe N2988 Q.sub.12 Me COOMe OMe OMe N2989 Me Q.sub.12 Me Me OMe CH2990 Me Q.sub.12 Me OMe OMe CH2991 Me Q.sub.12 Me Me OMe N2992 Me Me Q.sub.12 Me OMe CH2993 Me Me Q.sub.12 OMe OMe CH2994 Me Me Q.sub.12 Me OMe N2995 Q.sub.13 Me COOMe Me OMe CH2996 Q.sub.13 Me COOMe OMe OMe CH2997 Q.sub.13 Me COOMe Me OMe N2998 Me Me Q.sub.13 OMe OMe CH2999 Me Me Q.sub.13 Me OMe N3000 Q.sub.14 Me COOMe Me Me CH3001 Q.sub.14 Me COOMe Me OMe CH3002 Q.sub.14 Me COOMe OMe OMe CH3003 Q.sub.14 Me COOMe Me OMe N3004 Q.sub.14 Me COOMe OMe OMe N3005 Me Q.sub.14 Me Me OMe CH3006 Me Q.sub.14 Me OMe OMe CH3007 Me Q.sub.14 Me Me OMe N3008 Me Me Q.sub.14 Me OMe CH3009 Me Me Q.sub.14 OMe OMe CH3010 Me Me Q.sub.14 Me OMe N3011 Q.sub.15 Me COOMe Me Me CH3012 Q.sub.15 Me COOMe Me OMe CH3013 Q.sub.15 Me COOMe OMe OMe CH3014 Q.sub.15 Me COOMe Me OMe N3015 Q.sub.15 Me COOMe OMe OMe N3016 Me Q.sub.15 Me Me OMe CH3017 Me Q.sub.15 Me OMe OMe CH3018 Me Q.sub.15 Me Me OMe N3019 Me Me Q.sub.15 Me OMe CH3020 Me Me Q.sub.15 OMe OMe CH3021 Me Me Q.sub.15 Me OMe N3022 Q.sub.16 Me COOMe Me Me CH3023 Q.sub.16 Me COOMe Me OMe CH3024 Q.sub.16 Me COOMe OMe OMe CH3025 Q.sub.16 Me COOMe Me OMe N3026 Q.sub.16 Me COOMe OMe OMe N3027 Me Q.sub.16 Me Me OMe CH3028 Me Q.sub. 16 Me OMe OMe CH3029 Me Q.sub.16 Me Me OMe N3030 Me Me Q.sub.16 Me OMe CH3031 Me Me Q.sub.16 OMe OMe CH3032 Me Me Q.sub.16 Me OMe N3033 Q.sub.17 Me COMe Me OMe CH3034 Q.sub.17 Me COOMe OMe OMe CH3035 Q.sub.17 Me COOMe Me OMe N3036 Me Me Q.sub.17 OMe OMe CH3037 Me Me Q.sub.17 Me OMe N3038 Q.sub.18 Me COOMe Me Me CH3039 Q.sub.18 Me COOMe Me OMe CH3040 Q.sub.18 Me COOMe OMe OMe CH3041 Q.sub.18 Me COOMe Me OMe N3042 Q.sub.18 Me COOMe OMe OMe N3043 Me Q.sub.18 Me Me OMe CH3044 Me Q.sub.18 Me OMe OMe CH3045 Me Q.sub.18 Me Me OMe N3046 Me Me Q.sub.18 Me OMe CH3047 Me Me Q.sub.18 OMe OMe CH3048 Me Me Q.sub.18 Me OMe N3049 Q.sub.19 Me COOMe Me Me CH3050 Q.sub.19 Me COOMe Me OMe CH3051 Q.sub.19 Me COOMe OMe OMe CH3052 Q.sub.19 Me COOMe Me OMe N3053 Q.sub.19 Me COOMe OMe OMe N3054 Me Q.sub.19 Me Me OMe CH3055 Me Q.sub.19 Me OMe OMe CH3056 Me Q.sub.19 Me Me OMe N3057 Me Me Q.sub.19 Me OMe CH3058 Me Me Q.sub.19 OMe OMe CH3059 Me Me Q.sub.19 Me OMe N3060 Q.sub.20 Me COOMe Me Me CH3061 Q.sub.20 Me COOMe Me OMe CH3062 Q.sub.20 Me COOMe OMe OMe CH3063 Q.sub.20 Me COOMe Me OMe N3064 Q.sub.20 Me COOMe OMe OMe N3065 Me Q.sub.20 Me Me OMe CH3066 Me Q.sub.20 Me OMe OMe CH3067 Me Q.sub.20 Me Me OMe N3068 Me Me Q.sub.20 Me OMe CH3069 Me Me Q.sub.20 OMe OMe CH3070 Me Me Q.sub.20 Me OMe N3071 Q.sub.21 Me COOMe Me Me CH3072 Q.sub.21 Me COOMe Me OMe CH3073 Q.sub.21 Me COOMe OMe OMe CH3074 Q.sub.21 Me COOMe Me OMe N3075 Q.sub.21 Me COOMe OMe OMe N3076 Me Q.sub.21 Me Me OMe CH3077 Me Q.sub.21 Me OMe OMe CH3078 Me Q.sub.21 Me Me OMe N3079 Me Me Q.sub.21 Me OMe CH3080 Me Me Q.sub.21 OMe OMe CH3081 Me Me Q.sub.21 Me OMe N3082 Q.sub.22 Me COOMe Me Me CH3083 Q.sub.22 Me COOMe Me OMe CH3084 Q.sub.22 Me COOMe OMe OMe CH3085 Q.sub.22 Me COOMe Me OMe N3086 Q.sub.22 Me COOMe OMe OMe N3087 Me Q.sub.22 Me Me OMe CH3088 Me Q.sub.22 Me OMe OMe CH3089 Me Q.sub.22 Me Me OMe N3090 Me Me Q.sub.22 Me OMe CH3091 Me Me Q.sub.22 OMe OMe CH3092 Me Me Q.sub.22 Me OMe N3093 Q.sub.23 Me COOMe Me OMe CH3094 Q.sub.23 Me COOMe OMe OMe CH3095 Q.sub.23 Me COOMe Me OMe N3096 Me Me Q.sub.23 OMe OMe CH3097 Me Me Q.sub.23 Me OMe N3098 Q.sub.24 Me COOMe Me Me CH3099 Q.sub.24 Me COOMe Me OMe CH3100 Q.sub.24 Me COOMe OMe OMe CH3101 Q.sub.242 Me COOMe Me OMe N3102 Q.sub.24 Me COOMe OMe OMe N3103 Me Q.sub.24 Me Me OMe CH3104 Me Q.sub.24 Me OMe OMe CH3105 Me Q.sub.24 Me Me OMe N3106 Me Me Q.sub.24 Me OMe CH3107 Me Me Q.sub.24 OMe OMe CH3108 Me Me Q.sub.24 Me OMe N3109 Q.sub.25 Me COOMe Me Me CH3110 Q.sub.25 Me COOMe Me OMe CH3111 Q.sub.25 Me COOMe OMe OMe CH3112 Q.sub.25 Me COOMe Me OMe N3113 Q.sub.25 Me COOMe OMe OMe N3114 Me Q.sub.25 Me Me OMe CH3115 Me Q.sub.25 Me OMe OMe CH3116 Me Q.sub.25 Me Me OMe N3117 Me Me Q.sub.25 Me OMe CH3118 Me Me Q.sub.25 OMe OMe CH3119 Me Me Q.sub.25 Me OMe N3120 Q.sub.26 Me COOMe Me OMe CH3121 Q.sub.26 Me COOMe OMe OMe CH3122 Q.sub.26 Me COOMe Me OMe N3123 Me Me Q.sub.26 OMe OMe CH3124 Me Me Q.sub.26 Me OMe N3125 Q.sub.27 Me COOMe Me OMe CH3126 Q.sub.27 Me COOMe OMe OMe CH3127 Q.sub.27 Me COOMe Me OMe N3128 Me Me Q.sub.27 OMe OMe CH3129 Me Me Q.sub.27 Me OMe N3130 Q.sub.28 Me COOMe Me Me CH3131 Q.sub.28 Me COOMe Me OMe CH3132 Q.sub.28 Me COOMe OMe OMe CH3133 Q.sub.28 Me COOMe Me OMe N3134 Q.sub.28 Me COOMe OMe OMe N3135 Me Q.sub.28 Me Me OMe CH3136 Me Q.sub.28 Me OMe OMe CH3137 Me Q.sub.28 Me Me OMe N3138 Me Me Q.sub.28 Me OMe CH3139 Me Me Q.sub.28 OMe OMe CH3140 Me Me Q.sub.28 Me OMe N3141 Q.sub.29 Me COOMe Me OMe CH3142 Q.sub.29 Me COOMe OMe OMe CH3143 Q.sub.29 Me COOMe Me OMe N3144 Me Me Q.sub.29 OMe OMe CH3145 Me Me Q.sub.29 Me OMe N3146 Q.sub.30 Me COOMe Me OMe CH3147 Q.sub.30 Me COOMe OMe OMe CH3148 Q.sub.30 Me COOMe Me OMe N3149 Me Me Q.sub.30 OMe OMe CH3150 Me Me Q.sub.30 Me OMe N3151 Q.sub.31 Me COOMe Me OMe CH3152 Q.sub.31 Me COOMe OMe OMe CH3153 Q.sub.31 Me COOMe Me OMe N3154 Me Me Q.sub.31 OMe OMe CH3155 Me Me Q.sub.31 Me OMe N3156 Q.sub.32 Me Cl Me Me CH3157 Q.sub.32 Me Cl Me OMe CH3158 Q.sub.32 Me Cl OMe OMe N3159 Q.sub.32 Me Cl Me OMe N3160 Q.sub.32 Me Cl OMe OMe N3161 Q.sub.32 Me OMe Me OMe CH3162 Q.sub.32 Me OMe OMe OMe CH3163 Q.sub.32 Me OMe Me OMe N3164 Q.sub.32 CF.sub.3 Me Me OMe CH3165 Q.sub.32 CF.sub.3 Me OMe OMe CH3166 Q.sub.32 CF.sub.3 Me Me OMe N3167 Q.sub.32 Me COOMe Me Me CH3168 Q.sub.32 Me COOMe Me OMe CH3169 Q.sub.32 Me COOMe OMe OMe CH3170 Q.sub.32 Me COOMe Me OMe N3171 Q.sub.32 Me COOMe OMe OMe N3172 Q.sub.32 Me COOMe Me OCHF.sub.2 CH3173 Q.sub.32 Me COOMe Me ##STR24## CH3174 Q.sub.32 Me SO.sub.2 Me Me OMe CH3175 Q.sub.32 Me SO.sub.2 Me OMe OMe CH3176 Q.sub.32 Me SO.sub.2 Me Me OMe N3177 H Q.sub.32 Me Me OMe CH3178 H Q.sub.32 Me OMe OMe CH3179 H Q.sub.32 Me Me OMe N3180 Me Q.sub.32 Me Me OMe CH3181 Me Q.sub.32 Me OMe OMe CH3182 Me Q.sub.32 Me Me OMe N3183 Me Q.sub.32 Cl Me OMe CH3184 Me Q.sub.32 Cl OMe OMe CH3185 Me Q.sub.32 Cl Me OMe N3186 Me Q.sub.32 COOMe Me OMe CH3187 Me Q.sub.32 COOMe OMe OMe CH3188 Me Q.sub.32 COOMe Me OMe N3189 Me Q.sub.32 Ph Me OMe CH3190 Me Q.sub.32 Ph OMe OMe CH3191 Me Q.sub.32 Ph Me OMe N3192 Me Me Q.sub.32 Me OMe CH3193 Me Me Q.sub.32 OMe OMe CH3194 Me Me Q.sub.32 Me OMe N3195 Q.sub.33 Me COOMe Me Me CH3196 Q.sub.33 Me COOMe Me OMe CH3197 Q.sub.33 Me COOMe OMe OMe CH3198 Q.sub.33 Me COOMe Me OMe N3199 Q.sub.33 Me COOMe OMe OMe N3200 Me Q.sub.33 Me Me OMe CH3201 Me Q.sub.33 Me OMe OMe CH3202 Me Q.sub.33 Me Me OMe N3203 Me Me Q.sub.33 Me OMe CH3204 Me Me Q.sub.33 OMe OMe CH3205 Me Me Q.sub.33 Me OMe N3206 Q.sub.34 Me COOMe Me Me CH3207 Q.sub.34 Me COOMe Me OMe CH3208 Q.sub.34 Me COOMe OMe OMe CH3209 Q.sub.34 Me COOMe Me OMe N3210 Q.sub.34 Me COOMe OMe OMe N3211 Me Q.sub.34 Me Me OMe CH3212 Me Q.sub.34 Me Me OMe CH3213 Me Q.sub.34 Me Me OMe N3214 Me Me Q.sub.34 Me OMe CH3215 Me Me Q.sub.34 OMe OMe CH3216 Me Me Q.sub.34 Me OMe N3217 Q.sub.35 Me COOMe Me Me CH3218 Q.sub.35 Me COOMe Me OMe CH3219 Q.sub.35 Me COOMe OMe OMe CH3220 Q.sub.35 Me COOMe Me OMe N3221 Q.sub.35 Me COOMe OMe OMe N3222 Me Q.sub.35 Me Me OMe CH3223 Me Q.sub.35 Me OMe OMe CH3224 Me Q.sub.35 Me Me OMe N3225 Me Me Q.sub.35 Me OMe CH3226 Me Me Q.sub.35 OMe OMe CH3227 Me Me Q.sub.35 Me OMe N3228 Q.sub.36 Me COOMe Me OMe CH3229 Q.sub.36 Me COOMe OMe OMe CH3230 Q.sub.36 Me COOMe Me OMe N3231 Me Me Q.sub.36 OMe OMe CH3232 Me Me Q.sub.36 Me OMe N3233 Q.sub.37 Me COOMe Me Me CH3234 Q.sub.37 Me COOMe Me OMe CH3235 Q.sub.37 Me COOMe OMe OMe CH3236 Q.sub.37 Me COOMe Me OMe N3237 Q.sub.37 Me COOMe OMe OMe N3238 Me Q.sub.37 Me Me OMe CH3239 Me Q.sub.37 Me OMe OMe CH3240 Me Q.sub.37 Me Me OMe N3241 Me Me Q.sub.37 Me OMe CH3242 Me Me Q.sub.37 OMe OMe CH3243 Me Me Q.sub.37 Me OMe N3244 Q.sub.38 Me COOMe Me Me CH3245 Q.sub.38 Me COOMe Me OMe CH3246 Q.sub.38 Me COOMe OMe OMe CH3247 Q.sub.38 Me COOMe Me OMe N3248 Q.sub.38 Me COOMe OMe OMe N3249 Me Q.sub.38 Me Me OMe CH3250 Me Q.sub.38 Me OMe OMe CH3251 Me Q.sub.38 Me Me OMe N3152 Me Me Q.sub.38 Me OMe CH3253 Me Me Q.sub.38 OMe OMe CH3254 Me Me Q.sub.38 Me OMe N3255 Q.sub.39 Me COOMe Me Me CH3256 Q.sub.39 Me COOMe Me OMe CH3257 Q.sub.39 Me COOMe OMe OMe CH3258 Q.sub.39 Me COOMe Me OMe N3259 Q.sub.39 Me COOMe OMe OMe N3260 Me Q.sub.39 Me Me OMe CH3261 Me Q.sub.39 Me OMe OMe CH3262 Me Q.sub.39 Me Me OMe N3263 Me Me Q.sub.39 Me OMe CH3264 Me Me Q.sub.39 OMe OMe CH3265 Me Me Q.sub.39 Me OMe N3266 Q.sub.40 Me COOMe Me OMe CH3267 Q.sub.40 Me COOMe OMe OMe CH3268 Q.sub.40 Me COOMe Me OMe N3269 Me Me Q.sub.40 OMe OMe CH3270 Me Me Q.sub.40 Me OMe N3271 Q.sub.41 Me COOMe Me Me CH3272 Q.sub.41 Me COOMe Me OMe CH3273 Q.sub.41 Me COOMe OMe OMe CH3274 Q.sub.41 Me COOMe Me OMe N3275 Q.sub.41 Me COOMe OMe OMe N3276 Me Q.sub.41 Me Me OMe CH3277 Me Q.sub.41 Me OMe OMe CH3278 Me Q.sub.41 Me Me OMe N3279 Me Me Q.sub.41 Me OMe CH3280 Me Me Q.sub.41 OMe OMe CH3281 Me Me Q.sub.41 Me OMe N3282 Q.sub.42 Me COOMe Me Me CH3283 Q.sub.42 Me COOMe Me OMe CH3284 Q.sub.42 Me COOMe OMe OMe CH3285 Q.sub.42 Me COOMe Me OMe N3286 Q.sub.42 Me COOMe OMe OMe N3287 Me Q.sub.42 Me Me OMe CH3288 Me Q.sub.42 Me OMe OMe CH3289 Me Q.sub.42 Me Me OMe N3290 Me Me Q.sub.42 Me OMe CH3291 Me Me Q.sub.42 OMe OMe CH3292 Me Me Q.sub.42 Me OMe N3293 Q.sub.43 Me COOMe Me Me CH3294 Q.sub.43 Me COOMe Me OMe CH3295 Q.sub.43 Me COOMe OMe OMe CH3296 Q.sub.43 Me COOMe Me OMe N3297 Q.sub.43 Me COOMe OMe OMe N3298 Me Q.sub.43 Me Me OMe CH3299 Me Q.sub.43 Me OMe OMe CH3300 Me Q.sub.43 Me Me OMe N3301 Me Me Q.sub.43 Me OMe CH3302 Me Me Q.sub. 43 OMe OMe CH3303 Me Me Q.sub.43 Me OMe N3304 Q.sub.44 Me COOMe Me OMe CH3305 Q.sub.44 Me COOMe OMe OMe CH3306 Q.sub.44 Me COOMe Me OMe N3307 Me Me Q.sub.44 OMe OMe CH3308 Me Me Q.sub.44 Me OMe N3309 Q.sub.45 Me Cl Me Me CH3310 Q.sub.45 Me Cl Me OMe CH3311 Q.sub.45 Me Cl OMe OMe CH3312 Q.sub.45 Me Cl Me OMe N3313 Q.sub.45 Me Cl OMe OMe N3314 Q.sub.45 Me OMe Me OMe CH3315 Q.sub.45 Me OMe OMe OMe CH3316 Q.sub.45 Me OMe Me OMe N3317 Q.sub.45 CF.sub.3 Me Me OMe CH3318 Q.sub.45 CF.sub.3 Me OMe OMe CH3319 Q.sub.45 CF.sub.3 Me Me OMe N3320 Q.sub.45 Me COOMe Me Me CH3321 Q.sub.45 Me COOMe Me OMe CH3322 Q.sub.45 Me COOMe OMe OMe CH3323 Q.sub.45 Me COOMe Me OMe N3324 Q.sub.45 Me COOMe OMe OMe N3325 Q.sub.45 Me COOMe Me OCHF.sub.2 CH3326 Q.sub.45 Me COOMe Me ##STR25## CH3327 Q.sub.45 Me SO.sub.2 Me Me OMe CH3328 Q.sub.45 Me SO.sub.2 Me OMe OMe CH3329 Q.sub.45 Me SO.sub.2 Me Me OMe N3330 H Q.sub.45 Me Me OMe CH3331 H Q.sub.45 Me OMe OMe CH3332 H Q.sub.45 Me Me OMe N3333 Me Q.sub.45 Me Me OMe CH3334 Me Q.sub.45 Me OMe OMe CH3335 Me Q.sub.45 Me Me OMe N3336 Me Q.sub.45 Cl Me OMe CH3337 Me Q.sub.45 Cl OMe OMe CH3338 Me Q.sub.45 Cl Me OMe N3339 Me Q.sub.45 COOMe Me OMe CH3340 Me Q.sub.45 COOMe OMe OMe CH3341 Me Q.sub.45 COOMe Me OMe N3342 Me Q.sub.45 Ph Me OMe CH3343 Me Q.sub.45 Ph OMe OMe CH3344 Me Q.sub.45 Ph Me OMe N3345 Me Me Q.sub.45 Me OMe CH3346 Me Me Q.sub.45 OMe OMe CH3347 Me Me Q.sub.45 Me OMe N3348 Q.sub.46 Me COOMe Me Me CH3349 Q.sub.46 Me COOMe Me OMe CH3350 Q.sub.46 Me COOMe OMe OMe CH3351 Q.sub.46 Me COOMe Me OMe N3352 Q.sub.46 Me COOMe OMe OMe N3353 Me Q.sub.46 Me Me OMe CH3354 Me Q.sub.46 Me OMe OMe CH3355 Me Q.sub.46 Me Me OMe N3356 Me Me Q.sub.46 Me OMe CH3357 Me Me Q.sub.46 OMe OMe CH3358 Me Me Q.sub.46 Me OMe N3359 Q.sub.47 Me COOMe Me Me CH3360 Q.sub.47 Me COOMe Me OMe CH3361 Q.sub.47 Me COOMe OMe OMe CH3362 Q.sub.47 Me COOMe Me OMe N3363 Q.sub.47 Me COOMe OMe OMe N3364 Me Q.sub.47 Me Me OMe CH3365 Me Q.sub.47 Me OMe OMe CH3366 Me Q.sub.47 Me Me OMe N3367 Me Me Q.sub.47 Me OMe CH3368 Me Me Q.sub.47 OMe OMe CH3369 Me Me Q.sub.47 Me OMe N3370 Q.sub.48 Me COOMe Me Me CH3371 Q.sub.48 Me COOMe Me OMe CH3372 Q.sub.48 Me COOMe OMe OMe CH3373 Q.sub.48 Me COOMe Me OMe N3374 Q.sub.48 Me COOMe OMe OMe N3375 Me Q.sub.48 Me Me OMe CH3376 Me Q.sub.48 Me OMe OMe CH3377 Me Q.sub.48 Me Me OMe CH3378 Me Me Q.sub.48 Me OMe CH3379 Me Me Q.sub.48 OMe OMe CH3380 Me Me Q.sub.48 Me OMe N3381 Q.sub.49 Me COOMe Me Me CH3382 Q.sub.49 Me COOMe Me OMe CH3383 Q.sub.49 Me COOMe OMe OMe CH3384 Q.sub.49 Me COOMe Me OMe N3385 Q.sub.49 Me COOMe OMe OMe N3386 Me Q.sub.49 Me Me OMe CH3387 Me Q.sub.49 Me OMe OMe CH3388 Me Q.sub.49 Me Me OMe N3389 Me Me Q.sub.49 Me OMe CH3390 Me Me Q.sub.49 OMe OMe CH3391 Me Me Q.sub.49 Me OMe N3392 Q.sub.50 Me COOMe Me Me CH3393 Q.sub.50 Me COOMe Me OMe CH3394 Q.sub.50 Me COOMe OMe OMe CH3395 Q.sub.50 Me COOMe Me OMe N3396 Q.sub.50 Me COOMe OMe OMe N3397 Me Q.sub.50 Me Me OMe CH3398 Me Q.sub.50 Me OMe OMe CH3399 Me Q.sub.50 Me Me OMe N3400 Me Me Q.sub.50 Me OMe CH3401 Me Me Q.sub.50 OMe OMe CH3402 Me Me Q.sub.50 Me OMe N3403 Q.sub.51 Me COOMe Me Me CH3404 Q.sub.51 Me COOMe Me OMe CH3405 Q.sub.51 Me COOMe OMe OMe CH3406 Q.sub.51 Me COOMe Me OMe N3407 Q.sub.51 Me COOMe OMe OMe N3408 Me Q.sub.51 Me Me OMe CH3409 Me Q.sub.51 Me OMe OMe CH3410 Me Q.sub.51 Me Me OMe N3411 Me Me Q.sub.51 Me OMe CH3412 Me Me Q.sub.51 OMe OMe CH3413 Me Me Q.sub.51 Me OMe N3414 Q.sub.52 Me COOMe Me OMe CH3415 Q.sub.52 Me COOMe OMe OMe CH3416 Q.sub.52 Me COOMe Me OMe N3417 Me Me Q.sub.52 OMe OMe CH3418 Me Me Q.sub.52 Me OMe N3419 Q.sub.53 Me COOMe Me OMe CH3420 Q.sub.53 Me COOMe OMe OMe CH3421 Q.sub.53 Me COOMe Me OMe N3422 Me Me Q.sub.53 OMe OMe CH3423 Me Me Q.sub.53 Me OMe N3424 Q.sub.54 Me COOMe Me Me CH3425 Q.sub.54 Me COOMe Me OMe CH3426 Q.sub.54 Me COOMe OMe OMe CH3427 Q.sub.54 Me COOMe Me OMe N3428 Q.sub.54 Me COOMe OMe OMe N3429 Me Q.sub.54 Me Me OMe CH3430 Me Q.sub.54 Me OMe OMe CH3431 Me Q.sub.54 Me Me OMe N3432 Me Me Q.sub.54 Me OMe CH3433 Me Me Q.sub.54 OMe OMe CH3434 Me Me Q.sub.54 Me OMe N3435 Q.sub.55 Me COOMe Me Me CH3436 Q.sub.55 Me COOMe Me OMe CH3437 Q.sub.55 Me COOMe OMe OMe CH3438 Q.sub.55 Me COOMe Me OMe N3439 Q.sub.55 Me COOMe OMe OMe N3440 Me Q.sub.55 Me Me OMe CH3441 Me Q.sub.55 Me OMe OMe CH3442 Me Q.sub.55 Me Me OMe N3443 Me Me Q.sub.55 Me OMe CH3444 Me Me Q.sub.55 OMe OMe CH3445 Me Me Q.sub.55 Me OMe N3446 Q.sub.56 Me COOMe Me Me CH3447 Q.sub.56 Me COOMe Me OMe CH3448 Q.sub.56 Me COOMe OMe OMe CH3449 Q.sub.56 Me COOMe Me OMe N3450 Q.sub.56 Me COOMe OMe OMe N3451 Me Q.sub.56 Me Me OMe CH3452 Me Q.sub.56 Me OMe OMe CH3453 Me Q.sub.56 Me Me OMe N3454 Me Me Q.sub.56 Me OMe CH3455 Me Me Q.sub.56 OMe OMe CH3456 Me Me Q.sub.56 Me OMe N3457 Q.sub.57 Me COOMe Me OMe CH3458 Q.sub.57 Me COOMe OMe OMe CH3459 Q.sub.57 Me COOMe Me OMe N3460 Me Me Q.sub.57 OMe OMe CH3461 Me Me Q.sub.57 Me OMe N3462 Q.sub.58 Me COOMe Me OMe CH3463 Q.sub.58 Me COOMe OMe OMe CH3464 Q.sub.58 Me COOMe Me OMe N3465 Me Me Q.sub.58 OMe OMe CH3466 Me Me Q.sub.58 Me OMe N3467 Q.sub.59 Me Cl Me Me CH3468 Q.sub.59 Me Cl Me OMe CH3469 Q.sub.59 Me Cl OMe OMe CH3470 Q.sub.59 Me Cl Me OMe N3471 Q.sub.59 Me Cl OMe OMe N3472 Q.sub.59 Me OMe Me OMe CH3473 Q.sub.59 Me OMe OMe OMe CH3474 Q.sub.59 Me OMe Me OMe N3475 Q.sub.59 CF.sub.3 Me Me OMe CH3476 Q.sub.59 CF.sub.3 Me OMe OMe CH3477 Q.sub.59 CF.sub.3 Me Me OMe N3478 Q.sub.59 Me COOMe Me Me CH3479 Q.sub.59 Me COOMe Me OMe CH3480 Q.sub.59 Me COOMe OMe OMe CH3481 Q.sub.59 Me COOMe Me OMe N3482 Q.sub.59 Me COOMe OMe OMe N3483 Q.sub.59 Me COOMe Me OCHF.sub.2 CH3484 Q.sub.59 Me COOMe Me ##STR26## CH3485 Q.sub.59 Me SO.sub.2 Me Me OMe CH3486 Q.sub.59 Me SO.sub.2 Me OMe OMe CH3487 Q.sub.59 Me SO.sub.2 Me Me OMe N3488 H Q.sub.59 Me Me OMe CH3489 H Q.sub.59 Me OMe OMe CH3490 H Q.sub.59 Me Me OMe N3491 Me Q.sub.59 Me Me OMe CH3492 Me Q.sub.59 Me OMe OMe CH3493 Me Q.sub.59 Me Me OMe N3494 Me Q.sub.59 Cl Me OMe CH3495 Me Q.sub.59 Cl OMe OMe CH3496 Me Q.sub.59 Cl Me OMe N3497 Me Q.sub.59 COOMe Me OMe CH3498 Me Q.sub.59 COOMe OMe OMe CH3499 Me Q.sub.59 COOMe Me OMe N3500 Me Q.sub.59 Ph Me OMe CH3501 Me Q.sub.59 Ph OMe OMe CH3502 Me Q.sub.59 Ph Me OMe N3503 Me Me Q.sub.59 Me OMe CH3504 Me Me Q.sub.59 OMe OMe CH3505 Me Me Q.sub.59 Me OMe N3506 Q.sub.60 Me COOMe Me Me CH3507 Q.sub.60 Me COOMe Me OMe CH3508 Q.sub.60 Me COOMe OMe OMe CH3509 Q.sub.60 Me COOMe Me OMe N3510 Q.sub.60 Me COOMe OMe OMe N3511 Me Q.sub.60 Me Me OMe CH3512 Me Q.sub.60 Me OMe OMe CH3513 Me Q.sub.60 Me Me OMe N3514 Me Me Q.sub.60 Me OMe CH3515 Me Me Q.sub.60 OMe OMe CH3516 Me Me Q.sub.60 Me OMe N3517 Q.sub.61 Me COOMe Me Me CH3518 Q.sub.61 Me COOMe Me OMe CH3519 Q.sub.61 Me COOMe OMe OMe CH3520 Q.sub.61 Me COOMe Me OMe N3521 Q.sub.61 Me COOMe OMe OMe N3522 Me Q.sub.61 Me Me OMe CH3523 Me Q.sub.61 Me OMe OMe CH3524 Me Q.sub.61 Me Me OMe N3525 Me Me Q.sub.61 Me OMe CH3526 Me Me Q.sub.61 OMe OMe CH3527 Me Me Q.sub.61 Me OMe N3528 Q.sub.62 Me COOMe Me Me CH3529 Q.sub.62 Me COOMe Me OMe CH3530 Q.sub.62 Me COOMe OMe OMe CH3531 Q.sub.62 Me COOMe Me OMe N3532 Q.sub.62 Me COOMe OMe OMe N3533 Me Q.sub.62 Me Me OMe CH3534 Me Q.sub.62 Me OMe OMe CH3535 Me Q.sub.62 Me Me OMe N3536 Me Me Q.sub.62 Me OMe CH3537 Me Me Q.sub.62 OMe OMe CH3538 Me Me Q.sub.62 Me OMe N3539 Q.sub.63 Me COOMe Me OMe CH3540 Q.sub.63 Me COOMe OMe OMe CH3541 Q.sub.63 Me COOMe Me OMe N3542 Me Me Q.sub.63 OMe OMe CH3543 Me Me Q.sub.63 Me OMe N3544 Q.sub.64 Me COOMe Me OMe CH3545 Q.sub.64 Me COOMe OMe OMe CH3546 Q.sub.64 Me COOMe Me OMe N3547 Me Me Q.sub.64 OMe OMe CH3548 Me Me Q.sub.64 Me OMe N3549 Q.sub.65 Me COOMe Me Me CH3550 Q.sub.65 Me COOMe Me OMe CH3551 Q.sub.65 Me COOMe OMe OMe CH3552 Q.sub.65 Me COOMe Me OMe N3553 Q.sub.65 Me COOMe OMe OMe N3554 Me Q.sub.65 Me Me OMe CH3555 Me Q.sub.65 Me OMe OMe CH3556 Me Q.sub.65 Me Me OMe N3557 Me Me Q.sub.65 Me OMe CH3558 Me Me Q.sub.65 OMe OMe CH3559 Me Me Q.sub.65 Me OMe N3560 Q.sub.66 Me COOMe Me OMe CH3561 Q.sub.66 Me COOMe OMe OMe CH3562 Q.sub.66 Me COOMe Me OMe N3563 Me Me Q.sub.66 OMe OMe CH3564 Me Me Q.sub.66 Me OMe N3565 Q.sub.67 Me COOMe Me OMe CH3566 Q.sub.67 Me COOMe OMe OMe CH3567 Q.sub.67 Me COOMe Me OMe N3568 Me Me Q.sub.67 OMe OMe CH3569 Me Me Q.sub.67 Me OMe N3570 Q.sub.68 Me COOMe Me OMe CH3571 Q.sub.68 Me COOMe OMe OMe CH3572 Q.sub.68 Me COOMe Me OMe N3573 Me Me Q.sub.68 OMe OMe CH3574 Me Me Q.sub.68 Me OMe N3575 Q.sub.69 Me COOMe Me OMe CH3576 Q.sub.69 Me COOMe OMe OMe CH3577 Q.sub.69 Me COOMe Me OMe N3578 Me Me Q.sub.69 OMe OMe CH3579 Me Me Q.sub.69 Me OMe N3580 Q.sub.70 Me COOMe Me Me CH3581 Q.sub.70 Me COOMe Me OMe CH3582 Q.sub.70 Me COOMe OMe OMe CH3583 Q.sub.70 Me COOMe Me OMe N3584 Q.sub.70 Me COOMe OMe OMe N3585 Me Q.sub.70 Me Me OMe CH3586 Me Q.sub.70 Me OMe OMe CH3587 Me Q.sub.70 Me Me OMe N3588 Me Me Q.sub.70 Me OMe CH3589 Me Me Q.sub.70 OMe OMe CH3590 Me Me Q.sub.70 Me OMe N3591 Q.sub.71 Me COOMe Me OMe CH3592 Q.sub.71 Me COOMe OMe OMe CH3593 Q.sub.71 Me COOMe Me OMe CH3594 Me Me Q.sub.71 OMe OMe CH3595 Me Me Q.sub.71 Me OMe N3596 Q.sub.72 Me COOMe Me OMe CH3597 Q.sub.72 Me COOMe OMe OMe CH3598 Q.sub.72 Me COOMe Me OMe N3599 Me Me Q.sub.72 OMe OMe CH3600 Me Me Q.sub.72 Me OMe N3601 Q.sub.73 Me COOMe Me OMe CH3602 Q.sub.73 Me COOMe OMe OMe CH3603 Q.sub.73 Me COOMe Me OMe N3604 Me Me Q.sub.73 OMe OMe CH3605 Me Me Q.sub.73 Me OMe N3606 Q.sub.74 Me COOMe Me OMe CH3607 Q.sub.74 Me COOMe OMe OMe CH3608 Q.sub.74 Me COOMe Me OMe N3609 Me Me Q.sub.74 OMe OMe CH3610 Me Me Q.sub.74 Me OMe N3611 Q.sub.75 Me COOMe Me OMe CH3612 Q.sub.75 Me COOMe OMe OMe CH3613 Q.sub.75 Me COOMe Me OMe N3614 Me Me Q.sub.75 OMe OMe CH3615 Me Me Q.sub.75 Me OMe N3616 Q.sub.76 Me COOMe Me OMe CH3617 Q.sub.76 Me COOMe OMe OMe CH3618 Q.sub.76 Me COOMe Me OMe N3619 Me Me Q.sub.76 OMe OMe CH3620 Me Me Q.sub.76 Me OMe N3621 Q.sub.1 Me Me Me Me CH3622 Q.sub.1 Me Me Me OMe CH3623 Q.sub.1 Me Me OMe OMe CH3624 Q.sub.1 Me Me Me OMe N3625 Q.sub.1 Me Me OMe OMe N3626 Q.sub.2 Me Me Me Me CH3627 Q.sub.2 Me Me Me OMe CH3628 Q.sub.2 Me Me OMe OMe CH3629 Q.sub.2 Me Me Me OMe N3630 Q.sub.2 Me Me OMe OMe N3631 Q.sub.3 Me Me Me Me CH3632 Q.sub.3 Me Me Me OMe CH3633 Q.sub.3 Me Me OMe OMe CH3634 Q.sub.3 Me Me Me OMe N3635 Q.sub.3 Me Me OMe OMe N3636 Q.sub.4 Me Me Me Me CH3637 Q.sub.4 Me Me Me OMe CH3638 Q.sub.4 Me Me OMe OMe CH3639 Q.sub.4 Me Me Me OMe N3640 Q.sub.4 Me Me OMe OMe N3641 Q.sub.5 Me Me Me Me CH3642 Q.sub.5 Me Me Me OMe CH3643 Q.sub.5 Me Me OMe OMe CH3644 Q.sub.5 Me Me Me OMe N3645 Q.sub.5 Me Me OMe OMe N3646 Q.sub.6 Me Me Me Me CH3647 Q.sub.6 Me Me Me OMe CH3648 Q.sub.6 Me Me OMe OMe CH3649 Q.sub.6 Me Me Me OMe N3650 Q.sub.6 Me Me OMe OMe N3651 Q.sub.7 Me Me Me OMe CH3652 Q.sub.7 Me Me OMe OMe CH3653 Q.sub.7 Me Me Me OMe N3654 Q.sub.8 Me Me Me Me CH3655 Q.sub.8 Me Me Me OMe CH3656 Q.sub.8 Me Me OMe OMe CH3657 Q.sub.8 Me Me Me OMe N3658 Q.sub.8 Me Me OMe OMe N3659 Q.sub.9 Me Me Me Me CH3660 Q.sub.9 Me Me Me OMe CH3661 Q.sub.9 Me Me OMe OMe CH3662 Q.sub.9 Me Me Me OMe N3663 Q.sub.9 Me Me OMe OMe N3664 Q.sub.10 Me Me Me Me CH3665 Q.sub.10 Me Me Me OMe CH3666 Q.sub.10 Me Me OMe OMe CH3667 Q.sub.10 Me Me Me OMe N3668 Q.sub.10 Me Me OMe OMe N3669 Q.sub.11 Me Me Me Me CH3670 Q.sub.11 Me Me Me OMe CH3671 Q.sub.11 Me Me OMe OMe CH3672 Q.sub.11 Me Me Me OMe N3673 Q.sub.11 Me Me OMe OMe N3674 Q.sub.12 Me Me Me Me CH3675 Q.sub.12 Me Me Me OMe CH3676 Q.sub.12 Me Me OMe OMe CH3677 Q.sub.12 Me Me Me OMe N3678 Q.sub.12 Me Me OMe OMe N3679 Q.sub.13 Me Me Me OMe CH3680 Q.sub.13 Me Me OMe OMe CH3681 Q.sub.13 Me Me Me OMe N3682 Q.sub.14 Me Me Me Me CH3683 Q.sub.14 Me Me Me OMe CH3684 Q.sub.14 Me Me OMe OMe CH3685 Q.sub.14 Me Me Me OMe N3686 Q.sub.14 Me Me OMe OMe N3687 Q.sub.15 Me Me Me Me CH3688 Q.sub.15 Me Me Me OMe CH3689 Q.sub.15 Me Me OMe OMe CH3690 Q.sub.15 Me Me Me OMe N3691 Q.sub.15 Me Me OMe OMe N3692 Q.sub.16 Me Me Me Me CH3693 Q.sub.16 Me Me Me OMe CH3694 Q.sub.16 Me Me OMe OMe CH3695 Q.sub.16 Me Me Me OMe N3696 Q.sub.16 Me Me OMe OMe N3697 Q.sub.17 Me Me Me OMe CH3698 Q.sub.17 Me Me OMe OMe CH3699 Q.sub.17 Me Me Me OMe N3700 Q.sub.18 Me Me Me Me CH3701 Q.sub.18 Me Me Me OMe CH3702 Q.sub.18 Me Me OMe OMe CH3703 Q.sub.18 Me Me Me OMe N3704 Q.sub.18 Me Me OMe OMe N3705 Q.sub.19 Me Me Me Me CH3706 Q.sub.19 Me Me Me OMe CH3707 Q.sub.19 Me Me OMe OMe CH3708 Q.sub.19 Me Me Me OMe N3709 Q.sub.19 Me Me OMe OMe N3710 Q.sub.20 Me Me Me Me CH3711 Q.sub.20 Me Me Me OMe CH3712 Q.sub.20 Me Me OMe OMe CH3713 Q.sub.20 Me Me Me OMe N3714 Q.sub.20 Me Me OMe OMe N3715 Q.sub.21 Me Me Me Me CH3716 Q.sub.21 Me Me Me OMe CH3717 Q.sub.21 Me Me OMe OMe CH3718 Q.sub.21 Me Me Me OMe N3719 Q.sub.21 Me Me OMe OMe N3720 Q.sub.22 Me Me Me Me CH3721 Q.sub.22 Me Me Me OMe CH3722 Q.sub.22 Me Me OMe OMe CH3723 Q.sub.22 Me Me Me OMe N3724 Q.sub.22 Me Me OMe OMe N3725 Q.sub.23 Me Me Me OMe CH3726 Q.sub.23 Me Me OMe OMe CH3727 Q.sub.23 Me Me Me OMe N3728 Q.sub.24 Me Me Me Me CH3729 Q.sub.24 Me Me Me OMe CH3730 Q.sub.24 Me Me OMe OMe CH3731 Q.sub.24 Me Me Me OMe N3732 Q.sub.24 Me Me OMe OMe N3733 Q.sub.25 Me Me Me Me CH3734 Q.sub.25 Me Me Me OMe CH3735 Q.sub.25 Me Me OMe OMe CH3736 Q.sub.25 Me Me Me OMe N3737 Q.sub.25 Me Me OMe OMe N3738 Q.sub.26 Me Me Me OMe CH3739 Q.sub.26 Me Me OMe OMe CH3740 Q.sub.26 Me Me Me OMe N3741 Q.sub.27 Me Me Me OMe CH3742 Q.sub.27 Me Me OMe OMe CH3743 Q.sub.27 Me Me Me OMe N3744 Q.sub.28 Me Me Me Me CH3745 Q.sub.28 Me Me Me OMe CH3746 Q.sub.28 Me Me OMe OMe CH3747 Q.sub.28 Me Me Me OMe N3748 Q.sub.28 Me Me OMe OMe N3749 Q.sub.29 Me Me Me OMe CH3750 Q.sub.29 Me Me OMe OMe CH3751 Q.sub.29 Me Me Me OMe N3752 Q.sub.30 Me Me Me OMe CH3753 Q.sub.30 Me Me OMe OMe CH3754 Q.sub.30 Me Me Me OMe N3755 Q.sub.31 Me Me Me OMe CH3756 Q.sub.31 Me Me OMe OMe CH3757 Q.sub.31 Me Me Me OMe N3758 Q.sub.32 Me Me Me Me CH3759 Q.sub.32 Me Me Me OMe CH3760 Q.sub.32 Me Me OMe OMe CH3761 Q.sub.32 Me Me Me OMe N3762 Q.sub.32 Me Me OMe OMe N3763 Q.sub.33 Me Me Me Me CH3764 Q.sub.33 Me Me Me OMe CH3765 Q.sub.33 Me Me OMe OMe CH3766 Q.sub.33 Me Me Me OMe N3767 Q.sub.33 Me Me OMe OMe N3768 Q.sub.34 Me Me Me Me CH3769 Q.sub.34 Me Me Me OMe CH3770 Q.sub.34 Me Me OMe OMe CH3771 Q.sub.34 Me Me Me OMe N3772 Q.sub.34 Me Me OMe OMe N3773 Q.sub.35 Me Me Me Me CH3774 Q.sub.35 Me Me Me OMe CH3775 Q.sub.35 Me Me OMe OMe CH3776 Q.sub.35 Me Me Me OMe N3777 Q.sub.35 Me Me OMe OMe N3778 Q.sub.36 Me Me Me OMe CH3779 Q.sub.36 Me Me OMe OMe CH3780 Q.sub.36 Me Me Me OMe N3781 Q.sub.37 Me Me Me Me CH3782 Q.sub.37 Me Me Me OMe CH3783 Q.sub.37 Me Me OMe OMe CH3784 Q.sub.37 Me Me Me OMe N3785 Q.sub.37 Me Me OMe OMe N3786 Q.sub.38 Me Me Me Me CH3787 Q.sub.38 Me Me Me OMe CH3788 Q.sub.38 Me Me OMe OMe CH3789 Q.sub.38 Me Me Me OMe N3790 Q.sub.38 Me Me OMe OMe N3791 Q.sub.39 Me Me Me Me CH3792 Q.sub.39 Me Me Me OMe CH3793 Q.sub.39 Me Me OMe OMe CH3794 Q.sub.39 Me Me Me OMe N3795 Q.sub.39 Me Me OMe OMe N3796 Q.sub.40 Me Me Me OMe CH3797 Q.sub.40 Me Me OMe OMe CH3798 Q.sub.40 Me Me Me OMe N3799 Q.sub.41 Me Me Me Me CH3800 Q.sub.41 Me Me Me OMe CH3801 Q.sub.41 Me Me OMe OMe CH3802 Q.sub.41 Me Me Me OMe N3803 Q.sub.41 Me Me OMe OMe N3804 Q.sub.42 Me Me Me Me CH3805 Q.sub.42 Me Me Me OMe CH3806 Q.sub.42 Me Me OMe OMe CH3807 Q.sub.42 Me Me Me OMe N3808 Q.sub.42 Me Me OMe OMe N3809 Q.sub.43 Me Me Me Me CH3810 Q.sub.43 Me Me Me OMe CH3811 Q.sub.43 Me Me OMe OMe CH3812 Q.sub.43 Me Me Me OMe N3813 Q.sub.43 Me Me OMe OMe N3814 Q.sub.44 Me Me Me OMe CH3815 Q.sub.44 Me Me OMe OMe CH3816 Q.sub.44 Me Me Me OMe N3817 Q.sub.45 Me Me Me Me CH3818 Q.sub.45 Me Me Me OMe CH3819 Q.sub.45 Me Me OMe OMe CH3820 Q.sub.45 Me Me Me OMe N3821 Q.sub.45 Me Me OMe OMe N3822 Q.sub.46 Me Me Me Me CH3823 Q.sub.46 Me Me Me OMe CH3824 Q.sub.46 Me Me OMe OMe CH3825 Q.sub.46 Me Me Me OMe N3826 Q.sub.46 Me Me OMe OMe N3827 Q.sub.47 Me Me Me Me CH3828 Q.sub.47 Me Me Me OMe CH3829 Q.sub.47 Me Me OMe OMe CH3830 Q.sub.47 Me Me Me OMe N3831 Q.sub.47 Me Me OMe OMe N3832 Q.sub.48 Me Me Me Me CH3833 Q.sub.48 Me Me Me OMe CH3834 Q.sub.48 Me Me OMe OMe CH3835 Q.sub.48 Me Me Me OMe N3836 Q.sub.48 Me Me OMe OMe N3837 Q.sub.49 Me Me Me Me CH3838 Q.sub.49 Me Me Me OMe CH3839 Q.sub.49 Me Me OMe OMe CH3840 Q.sub.49 Me Me Me OMe N3841 Q.sub.49 Me Me OMe OMe N3842 Q.sub.50 Me Me Me Me CH3843 Q.sub.50 Me Me Me OMe CH3844 Q.sub.50 Me Me OMe OMe CH3845 Q.sub.50 Me Me Me OMe N3846 Q.sub.50 Me Me OMe OMe N3847 Q.sub.51 Me Me Me Me CH3848 Q.sub.51 Me Me Me OMe CH3849 Q.sub.51 Me Me OMe OMe CH3850 Q.sub.51 Me Me Me OMe N3851 Q.sub.51 Me Me OMe OMe N3852 Q.sub.52 Me Me Me OMe CH3853 Q.sub.52 Me Me OMe OMe CH3854 Q.sub.52 Me Me Me OMe N3855 Q.sub.53 Me Me Me OMe CH3856 Q.sub.53 Me Me OMe OMe CH3857 Q.sub.53 Me Me Me OMe N3858 Q.sub.54 Me Me Me Me CH3859 Q.sub.54 Me Me Me OMe CH3860 Q.sub.54 Me Me OMe OMe CH3861 Q.sub.54 Me Me Me OMe N3862 Q.sub.54 Me Me OMe OMe N3863 Q.sub.55 Me Me Me Me CH3864 Q.sub.55 Me Me Me OMe CH3865 Q.sub.55 Me Me OMe OMe CH3866 Q.sub.55 Me Me Me OMe N3867 Q.sub.55 Me Me OMe OMe N3868 Q.sub.56 Me Me Me Me CH3869 Q.sub.56 Me Me Me OMe CH3870 Q.sub.56 Me Me OMe OMe CH3871 Q.sub.56 Me Me Me OMe N3872 Q.sub.56 Me Me OMe OMe N3873 Q.sub.57 Me Me Me OMe CH3874 Q.sub.57 Me Me OMe OMe CH3875 Q.sub.57 Me Me Me OMe N3876 Q.sub.58 Me Me Me OMe CH3877 Q.sub.58 Me Me OMe OMe CH3878 Q.sub.58 Me Me Me OMe N3879 Q.sub.59 Me Me Me Me CH3880 Q.sub.59 Me Me Me OMe CH3881 Q.sub.59 Me Me OMe OMe CH3882 Q.sub.59 Me Me Me OMe N3883 Q.sub.59 Me Me OMe OMe N3884 Q.sub.60 Me Me Me Me CH3885 Q.sub.60 Me Me OMe OMe CH3886 Q.sub.60 Me Me OMe OMe CH3887 Q.sub.60 Me Me Me OMe N3888 Q.sub.60 Me Me OMe OMe N3889 Q.sub.61 Me Me Me Me CH3890 Q.sub.61 Me Me Me OMe CH3891 Q.sub.61 Me Me OMe OMe CH3892 Q.sub.61 Me Me Me OMe N3893 Q.sub.61 Me Me OMe OMe N3894 Q.sub.62 Me Me Me Me CH3895 Q.sub.62 Me Me OMe OMe CH3896 Q.sub.62 Me Me OMe OMe CH3897 Q.sub.62 Me Me Me OMe N3898 Q.sub.62 Me Me OMe OMe N3899 Q.sub.63 Me Me OMe OMe CH3900 Q.sub.63 Me Me OMe OMe CH3901 Q.sub.63 Me Me Me OMe N3902 Q.sub.64 Me Me Me OMe CH3903 Q.sub.64 Me Me OMe OMe CH3904 Q.sub.64 Me Me Me OMe N3905 Q.sub.65 Me Me Me Me CH3906 Q.sub.65 Me Me Me OMe CH3907 Q.sub.65 Me Me OMe OMe CH3908 Q.sub.65 Me Me Me OMe N3909 Q.sub.65 Me Me OMe OMe N3910 Q.sub.66 Me Me Me OMe CH3911 Q.sub.66 Me Me OMe OMe CH3912 Q.sub.66 Me Me Me OMe N3913 Q.sub.67 Me Me OMe OMe CH3914 Q.sub.67 Me Me OMe OMe CH3915 Q.sub.67 Me Me Me OMe N3916 Q.sub.68 Me Me Me OMe CH3917 Q.sub.68 Me Me OMe OMe CH3918 Q.sub.68 Me Me Me OMe N3919 Q.sub.69 Me Me Me OMe CH3920 Q.sub.69 Me Me OMe OMe CH3921 Q.sub.69 Me Me Me OMe N3922 Q.sub.70 Me Me Me Me CH3923 Q.sub.70 Me Me Me OMe CH3924 Q.sub.70 Me Me OMe OMe CH3925 Q.sub.70 Me Me Me OMe N3926 Q.sub.70 Me Me OMe OMe N3927 Q.sub.71 Me Me Me OMe CH3928 Q.sub.81 Me Me OMe OMe CH3929 Q.sub.71 Me Me Me OMe N3930 Q.sub.72 Me Me Me OMe CH3931 Q.sub.72 Me Me OMe OMe CH3932 Q.sub.72 Me Me Me OMe N3933 Q.sub.73 Me Me Me OMe CH3934 Q.sub.73 Me Me OMe OMe CH3935 Q.sub.73 Me Me Me OMe N3936 Q.sub.74 Me Me Me OMe CH3937 Q.sub.74 Me Me OMe OMe CH3938 Q.sub.74 Me Me Me OMe N3939 Q.sub.75 Me Me Me OMe CH3940 Q.sub.75 Me Me OMe OMe CH3941 Q.sub.75 Me Me Me OMe N3942 Q.sub.76 Me Me Me OMe CH3943 Q.sub.76 Me Me OMe OMe CH3944 Q.sub.76 Me Me Me OMe N3945 Me Q.sub.3 COOMe Me OMe CH3946 Me Q.sub.3 COOMe OMe OMe CH3946 Me Q.sub.3 COOMe OMe OMe CH3946 Me Q.sub.3 COOMe OMe OMe CH3947 Me Q.sub.3 COOMe Me OMe N3948 Me Q.sub.4 COOMe Me OMe CH3949 Me Q.sub.4 COOMe OMe OMe CH3950 Me Q.sub.4 COOMe Me OMe N3951 Me Q.sub.6 COOMe Me OMe CH3952 Me Q.sub.6 COOMe OMe OMe CH3953 Me Q.sub.6 COOMe Me OMe N3954 Me Q.sub.9 COOMe Me OMe CH3955 Me Q.sub.9 COOMe OMe OMe CH3956 Me Q.sub.9 COOMe Me OMe N3957 Me Q.sub.10 COOMe Me OMe CH3958 Me Q.sub.10 COOMe OMe OMe CH3959 Me Q.sub.10 COOMe Me OMe N3960 Me Q.sub.11 COOMe Me OMe CH3961 Me Q.sub.11 COOMe OMe OMe CH3962 Me Q.sub.11 COOMe Me OMe N3963 Me Q.sub.12 COOMe Me OMe CH3964 Me Q.sub.12 COOMe OMe OMe CH3965 Me Q.sub.12 COOMe Me OMe N3966 Me Q.sub.14 COOMe Me OMe CH3967 Me Q.sub.14 COOMe OMe OMe CH3968 Me Q.sub.14 COOMe Me OMe N3969 Me Q.sub.15 COOMe Me OMe CH3970 Me Q.sub.15 COOMe OMe OMe CH3971 Me Q.sub.15 COOMe Me OMe N3972 Me Q.sub.16 COOMe Me OMe CH3973 Me Q.sub.16 COOMe OMe OMe CH3974 Me Q.sub.16 COOMe Me OMe N3975 Me Q.sub.18 COOMe Me OMe CH3976 Me Q.sub.18 COOMe OMe OMe CH3977 Me Q.sub.18 COOMe Me OMe N3978 Me Q.sub.19 COOMe Me OMe CH3979 Me Q.sub.19 COOMe OMe OMe CH3980 Me Q.sub.19 COOMe Me OMe N3981 Me Q.sub.20 COOMe Me OMe CH3982 Me Q.sub.20 COOMe OMe OMe CH3983 Me Q.sub.20 COOMe Me OMe N3984 Me Q.sub.21 COOMe Me OMe CH3985 Me Q.sub.21 COOMe OMe OMe CH3986 Me Q.sub.21 COOMe Me OMe N3987 Me Q.sub.22 COOMe Me OMe CH3988 Me Q.sub.22 COOMe OMe OMe CH3989 Me Q.sub.22 COOMe Me OMe N3990 Me Q.sub.24 COOMe Me OMe CH3991 Me Q.sub.24 COOMe OMe OMe CH3992 Me Q.sub.24 COOMe Me OMe N3993 Me Q.sub.25 COOMe Me OMe CH3994 Me Q.sub.25 COOMe OMe OMe CH3995 Me Q.sub.25 COOMe Me OMe N3996 Me Q.sub.28 COOMe Me OMe CH3997 Me Q.sub.28 COOMe OMe OMe CH3998 Me Q.sub.28 COOMe Me OMe N3999 Me Q.sub.33 COOMe Me OMe CH4000 Me Q.sub.33 COOMe OMe OMe CH4001 Me Q.sub.33 COOMe Me OMe N4002 Me Q.sub.34 COOMe Me OMe CH4003 Me Q.sub.34 COOMe OMe OMe CH4004 Me Q.sub.34 COOMe Me OMe N4005 Me Q.sub.35 COOMe Me OMe CH4006 Me Q.sub.35 COOMe OMe OMe CH4007 Me Q.sub.35 COOMe Me OMe N4008 Me Q.sub.37 COOMe Me OMe CH4009 Me Q.sub.37 COOMe OMe OMe CH4010 Me Q.sub.37 COOMe Me OMe N4011 Me Q.sub.38 COOMe Me OMe CH4012 Me Q.sub.38 COOMe OMe OMe CH4013 Me Q.sub.38 COOMe Me OMe N4014 Me Q.sub.39 COOMe Me OMe CH4015 Me Q.sub.39 COOMe OMe OMe CH4016 Me Q.sub.39 COOMe Me OMe N4017 Me Q.sub.41 COOMe Me OMe CH4018 Me Q.sub.41 COOMe OMe OMe CH4019 Me Q.sub.41 COOMe Me OMe N4020 Me Q.sub.42 COOMe Me OMe CH4021 Me Q.sub.42 COOMe OMe OMe CH4022 Me Q.sub.42 COOMe Me OMe N4023 Me Q.sub.43 COOMe Me OMe CH4024 Me Q.sub.43 COOMe OMe OMe CH4025 Me Q.sub.43 COOMe Me OMe N4026 Me Q.sub.46 COOMe Me OMe CH4027 Me Q.sub.46 COOMe OMe OMe CH4028 Me Q.sub.46 COOMe Me OMe N4029 Me Q.sub.47 COOMe Me OMe CH4030 Me Q.sub.47 COOMe OMe OMe CH4031 Me Q.sub.47 COOMe Me OMe N4032 Me Q.sub.48 COOMe Me OMe CH4033 Me Q.sub.48 COOMe OMe OMe CH4034 Me Q.sub.48 COOMe Me OMe N4035 Me Q.sub.49 COOMe Me OMe CH4036 Me Q.sub.49 COOMe OMe OMe CH4037 Me Q.sub.49 COOMe Me OMe N4038 Me Q.sub.50 COOMe Me OMe CH4039 Me Q.sub.50 COOMe OMe OMe CH4040 Me Q.sub.50 COOMe Me OMe N4041 Me Q.sub.51 COOMe Me OMe CH4042 Me Q.sub.51 COOMe OMe OMe CH4043 Me Q.sub.51 COOMe Me OMe N4044 Me Q.sub.54 COOMe OMe OMe CH4045 Me Q.sub.54 COOMe OMe OMe CH4046 Me Q.sub.54 COOMe Me OMe N4047 Me Q.sub.55 COOMe Me OMe CH4048 Me Q.sub.55 COOMe OMe OMe CH4049 Me Q.sub.55 COOMe Me OMe N4050 Me Q.sub.56 COOMe Me OMe CH4051 Me Q.sub.56 COOMe OMe OMe CH4052 Me Q.sub.56 COOMe Me OMe N4053 Me Q.sub.60 COOMe Me OMe CH4054 Me Q.sub.60 COOMe OMe OMe CH4055 Me Q.sub.60 COOMe Me OMe N4056 Me Q.sub.61 COOMe Me OMe CH4057 Me Q.sub.61 COOMe OMe OMe CH4058 Me Q.sub.61 COOMe Me OMe N4059 Me Q.sub.62 COOMe Me OMe CH4060 Me Q.sub.62 COOMe OMe OMe CH4061 Me Q.sub.62 COOMe Me OMe N4062 Me Q.sub.65 COOMe Me OMe CH4063 Me Q.sub.65 COOMe OMe OMe CH4064 Me Q.sub.65 COOMe Me OMe N4065 Me Q.sub.70 COOMe Me OMe CH4066 Me Q.sub.70 COOMe OMe OMe CH4067 Me Q.sub.70 COOMe Me OMe N4068 Me Q.sub.7 Me OMe OMe CH4069 Me Q.sub.7 Me Me OMe N4070 Me Q.sub.13 Me OMe OMe CH4071 Me Q.sub.13 Me Me OMe N4072 Me Q.sub.17 Me OMe OMe CH4073 Me Q.sub.17 Me Me OMe N4074 Me Q.sub.23 Me OMe OMe CH4075 Me Q.sub.23 Me Me OMe N4076 Me Q.sub.26 Me OMe OMe CH4077 Me Q.sub.26 Me Me OMe N4078 Me Q.sub.27 Me OMe OMe CH4079 Me Q.sub.27 Me Me OMe N4080 Me Q.sub.29 Me OMe OMe CH4081 Me Q.sub.29 Me Me OMe N4082 Me Q.sub.30 Me OMe OMe CH4083 Me Q.sub.30 Me Me OMe N4084 Me Q.sub.31 Me OMe OMe CH4085 Me Q.sub.31 Me Me OMe N4086 Me Q.sub.36 Me OMe OMe CH4087 Me Q.sub.36 Me Me OMe N4088 Me Q.sub.40 Me OMe OMe CH4089 Me Q.sub.40 Me Me OMe N4090 Me Q.sub.44 Me OMe OMe CH4091 Me Q.sub.44 Me Me OMe N4092 Me Q.sub.52 Me OMe OMe CH4093 Me Q.sub.52 Me Me OMe N4094 Me Q.sub.53 Me OMe OMe CH4095 Me Q.sub.53 Me Me OMe N4096 Me Q.sub.57 Me OMe OMe CH4097 Me Q.sub.57 Me Me OMe N4098 Me Q.sub.58 Me OMe OMe CH4099 Me Q.sub.58 Me Me OMe N4100 Me Q.sub.63 Me OMe OMe CH4101 Me Q.sub.63 Me Me OMe N4102 Me Q.sub.64 Me OMe OMe CH4103 Me Q.sub.64 Me Me OMe N4104 Me Q.sub.66 Me OMe OMe CH4105 Me Q.sub.66 Me Me OMe N4106 Me Q.sub.67 Me OMe OMe CH4107 Me Q.sub.67 Me Me OMe N4108 Me Q.sub.68 Me OMe OMe CH4109 Me Q.sub.68 Me Me OMe N4110 Me Q.sub.69 Me OMe OMe CH4111 Me Q.sub.69 Me Me OMe N4112 Me Q.sub.71 Me OMe OMe CH4113 Me Q.sub.71 Me Me OMe N4114 Me Q.sub.72 Me OMe OMe CH4115 Me Q.sub.72 Me Me OMe N4116 Me Q.sub.73 Me OMe OMe CH4117 Me Q.sub.73 Me Me OMe N4118 Me Q.sub.74 Me OMe OMe CH4119 Me Q.sub.74 Me Me OMe N4120 Me Q.sub.75 Me OMe OMe CH4121 Me Q.sub.75 Me Me OMe N4122 Me Q.sub.76 Me OMe OMe CH4123 Me Q.sub.76 Me Me OMe N5611 Q.sub.77 Me COOMe Me OMe CH5612 Q.sub.77 Me COOMe OMe OMe CH5613 Q.sub.77 Me COOMe Me OMe N5614 Me Me Q.sub.77 OMe OMe CH5615 Me Me Q.sub.77 Me OMe N5616 Q.sub.78 Me Cl Me Me CH5617 Q.sub.78 Me Cl Me OMe CH5618 Q.sub.78 Me Cl OMe OMe CH5619 Q.sub.78 Me Cl Me OMe N5620 Q.sub.78 Me Cl OMe OMe N5621 Q.sub.78 Me OMe Me OMe CH5622 Q.sub.78 Me OMe OMe OMe CH5623 Q.sub.78 Me OMe Me OMe N5624 Q.sub.78 CF.sub.3 Me Me OMe CH5625 Q.sub.78 CF.sub.3 Me OMe OMe CH5626 Q.sub.78 CF.sub.3 Me Me OMe N5627 Q.sub.78 Me COOMe Me Me CH5628 Q.sub.78 Me COOMe Me OMe CH5629 Q.sub.78 Me COOMe OMe OMe CH5630 Q.sub.78 Me COOMe Me OMe N5631 Q.sub.78 Me COOMe OMe OMe N5632 Q.sub.78 Me COOMe Me OCHF.sub.2 CH5633 Q.sub.78 Me COOMe Me ##STR27## CH5634 Q.sub.78 Me SO.sub.2 Me Me OMe CH5635 Q.sub.78 Me SO.sub.2 Me OMe OMe CH5636 Q.sub.78 Me SO.sub.2 Me Me OMe N5637 H Q.sub.78 Me Me OMe CH5638 H Q.sub.78 Me OMe OMe CH5639 H Q.sub.78 Me Me OMe N5640 Me Q.sub.78 Me Me OMe CH5641 Me Q.sub.78 Me OMe OMe CH5642 Me Q.sub.78 Me Me OMe N5643 Me Q.sub.78 Cl Me OMe CH5644 Me Q.sub.78 Cl OMe OMe CH5645 Me Q.sub.78 Cl Me OMe N5646 Me Q.sub.78 COOMe Me OMe CH5647 Me Q.sub.78 COOMe OMe OMe CH5648 Me Q.sub.78 COOMe Me OMe N5649 Me Q.sub.78 Ph Me OMe CH5650 Me Q.sub.78 Ph OMe OMe CH5651 Me Q.sub.78 Ph Me OMe N5652 Me Me Q.sub.78 Me OMe CH5653 Me Me Q.sub.78 OMe OMe CH5654 Me Me Q.sub.78 Me OMe N5655 Q.sub.79 Me Cl Me Me CH5656 Q.sub.79 Me Cl Me OMe CH5657 Q.sub.79 Me Cl OMe OMe CH5658 Q.sub.79 Me Cl Me OMe N5659 Q.sub.79 Me Cl OMe OMe N5660 Q.sub.79 Me OMe Me OMe CH5661 Q.sub.79 Me OMe OMe OMe CH5662 Q.sub.79 Me OMe Me OMe N5663 Q.sub.79 CF.sub.3 Me Me OMe CH5664 Q.sub.79 CF.sub.3 Me OMe OMe CH5665 Q.sub.79 CF.sub.3 Me Me OMe N5666 Q.sub.79 Me COOMe Me Me CH5667 Q.sub.79 Me COOMe Me OMe CH5668 Q.sub.79 Me COOMe OMe OMe CH5669 Q.sub.79 Me COOMe Me OMe N5670 Q.sub.79 Me COOMe OMe OMe N5671 Q.sub.79 Me COOMe Me OCHF.sub.2 CH5672 Q.sub.79 Me COOMe Me ##STR28## CH5673 Q.sub.79 Me SO.sub.2 Me Me OMe CH5674 Q.sub.79 Me SO.sub.2 Me OMe OMe CH5675 Q.sub.79 Me SO.sub.2 Me Me OMe N5676 H Q.sub.79 Me Me OMe CH5677 H Q.sub.79 Me OMe OMe CH5678 H Q.sub.79 Me Me OMe N5679 Me Q.sub.79 Me Me OMe CH5680 Me Q.sub.79 Me OMe OMe CH5681 Me Q.sub.79 Me Me OMe N5682 Me Q.sub.79 Cl Me OMe CH5683 Me Q.sub.79 Cl OMe OMe CH5684 Me Q.sub.79 Cl Me OMe N5685 Me Q.sub.79 COOMe Me OMe CH5686 Me Q.sub.79 COOMe OMe OMe CH5687 Me Q.sub.79 COOMe Me OMe N5688 Me Q.sub.79 Ph Me OMe CH5689 Me Q.sub.79 Ph OMe OMe CH5690 Me Q.sub.79 Ph Me OMe N5691 Me Me Q.sub.79 Me OMe CH5692 Me Me Q.sub.79 OMe OMe CH5693 Me Me Q.sub.79 Me OMe N5694 Q.sub.80 Me COOMe Me Me CH5695 Q.sub.80 Me COOMe Me OMe CH5696 Q.sub.80 Me COOMe OMe OMe CH5697 Q.sub.80 Me COOMe Me OMe N5698 Q.sub.80 Me COOMe OMe OMe N5699 Me Q.sub.80 Me Me OMe CH5700 Me Q.sub.80 Me OMe OMe CH5701 Me Q.sub.80 Me Me OMe N5702 Me Me Q.sub.80 Me OMe CH5703 Me Me Q.sub.80 OMe OMe CH5704 Me Me Q.sub.80 Me OMe N5705 Q.sub.81 Me COOMe Me OMe CH5706 Q.sub.81 Me COOMe OMe OMe CH5707 Q.sub.81 Me COOMe Me OMe N5708 Me Me Q.sub.81 OMe OMe CH5709 Me Me Q.sub.81 Me OMe N5710 Q.sub.82 Me COOMe Me OMe CH5711 Q.sub.82 Me COOMe OMe OMe CH5712 Q.sub.82 Me COOMe Me OMe N5713 Me Me Q.sub.83 OMe OMe CH5714 Me Me Q.sub.83 Me OMe N5715 Q.sub.83 Me COOMe Me OMe CH5716 Q.sub.83 Me COOMe OME OME CH5717 Q.sub.83 Me COOMe Me OMe N5718 Me Me Q.sub.83 OMe OMe CH5719 Me Me Q.sub.83 Me OMe N__________________________________________________________________________
In the above, Q.sub.1 to Q.sub.83 are as defined above.
TABLE 3__________________________________________________________________________ ##STR29##No. A B D X Y Z__________________________________________________________________________4124 Q.sub.1 H H Me Me CH4125 Q.sub.1 H H Me OMe CH4126 Q.sub.1 H H OMe OMe CH4127 Q.sub.1 H H Me OMe N4128 Q.sub.1 H H OMe OMe N4129 Q.sub.1 H H Me OCHF.sub.2 CH4130 Q.sub.1 H H Cl OMe CH4131 Q.sub.1 H H Me Me N4132 Q.sub.1 Me H Me Me CH4133 Q.sub.1 Me H Me OMe CH4134 Q.sub.1 Me H OMe OMe CH4135 Q.sub.1 Me H Me OMe N4136 Q.sub.1 Me H OMe OMe N4137 Q.sub.1 Me H Me OCHF.sub.2 CH4138 Q.sub.1 Me H Cl OMe CH4139 Q.sub.1 Me H Me Me N4140 Q.sub.1 Et H Me Me CH4141 Q.sub.1 Et H Me OMe CH4142 Q.sub.1 Et H OMe OMe CH4143 Q.sub.1 Et H Me OMe N4144 Q.sub.1 Et H OMe OMe N4145 Q.sub.1 Cl H Me Me CH4146 Q.sub.1 Cl H Me OMe CH4147 Q.sub.1 Cl H OMe OMe CH4148 Q.sub.1 Cl H Me OMe N4149 Q.sub.1 Cl H OMe OMe N4150 Q.sub.1 Br H Me Me CH4151 Q.sub.1 Br H Me OMe CH4152 Q.sub.1 Br H OMe OMe CH4153 Q.sub.1 Br H Me OMe N4154 Q.sub.1 Br H OMe OMe N4155 Q.sub.1 Br H Me OCHF.sub.2 CH4156 Q.sub.1 Br H Cl OMe CH4157 Q.sub.1 Br H Me Me N4158 Q.sub.1 NO.sub.2 H Me Me CH4159 Q.sub.1 NO.sub.2 H Me OMe CH4160 Q.sub.1 NO.sub.2 H OMe OMe CH4161 Q.sub.1 NO.sub.2 H Me OMe N4162 Q.sub. 1 NO.sub.2 H OMe OMe N4163 Q.sub.1 COOMe H Me Me CH4164 Q.sub.1 COOMe H Me OMe CH4165 Q.sub.1 COOMe H OMe OMe CH4166 Q.sub.1 COOMe H Me OMe N4167 Q.sub.1 COOMe H OMe OMe N4168 Q.sub.1 COOEt H Me Me CH4169 Q.sub.1 COOEt H Me OMe CH4170 Q.sub.1 COOEt H OMe OMe CH4171 Q.sub.1 COOEt H Me OMe N4172 Q.sub.1 COOEt H OMe OMe N4173 Q.sub.1 SO.sub.2 NMe.sub.2 H Me Me CH4174 Q.sub.1 SO.sub.2 NMe.sub.2 H Me OMe CH4175 Q.sub.1 SO.sub.2 NMe.sub.2 H OMe OMe CH4176 Q.sub.1 SO.sub.2 NMe.sub.2 H Me OMe N4177 Q.sub.1 SO.sub.2 NMe.sub.2 H OMe OMe N4178 Q.sub.1 Me Me Me OMe CH4179 Q.sub.1 Me Me OMe OMe CH4180 Q.sub.1 Me Me Me OMe N4181 Q.sub.1 Cl Me Me OMe CH4182 Q.sub.1 Cl Me OMe OMe CH4183 Q.sub.1 Cl Me Me OMe N4184 Q.sub.1 Br Me Me OMe CH4185 Q.sub. 1 Br Me OMe OMe CH4186 Q.sub.1 Br Me Me OMe N4187 Q.sub.1 COOMe Me Me OMe CH4188 Q.sub.1 COOMe Me OMe OMe CH4189 Q.sub.1 COOMe Me Me OMe N4190 Me Q.sub.1 H Me Me CH4191 Me Q.sub.1 H Me OMe CH4192 Me Q.sub.1 H OMe OMe CH4193 Me Q.sub.1 H Me OMe N4194 Me Q.sub.1 H OMe OMe N4195 Et Q.sub.1 H Me OMe CH4196 Et Q.sub.1 H OMe OMe CH4197 Et Q.sub.1 H Me OMe N4198 CH.sub.2 CHCH.sub.2 Q.sub.1 H Me OMe CH4199 CH.sub.2 CHCH.sub.2 Q.sub.1 H OMe OMe CH4200 CH.sub.2 CHCH.sub.2 Q.sub.1 H Me OMe N4201 CH.sub.2 CCH Q.sub.1 H Me OMe CH4202 CH.sub.2 CCH Q.sub.1 H OMe OMe CH4203 CH.sub.2 CCH Q.sub.1 H Me OMe N4204 CH.sub. 2 CN Q.sub.1 H Me OMe CH4205 CH.sub.2 CN Q.sub.1 H OMe OMe CH4206 CH.sub.2 CN Q.sub.1 H Me OMe N4207 CH.sub.2 COOMe Q.sub.1 H Me OMe CH4208 CH.sub.2 COOMe Q.sub.1 H OMe OMe CH4209 CH.sub.2 COOMe Q.sub.1 H Me OMe N4210 COMe Q.sub.1 H Me OMe CH4211 COMe Q.sub.1 H OMe OMe CH4212 COMe Q.sub.1 H Me OMe N4213 SO.sub.2 NMe.sub.2 Q.sub.1 H Me OMe CH4214 SO.sub.2 NMe.sub.2 Q.sub.1 H OMe OMe CH4215 SO.sub.2 NMe.sub.2 Q.sub.1 H Me OMe N4216 SO.sub.2 Me Q.sub.1 H Me OMe CH4217 SO.sub.2 Me Q.sub.1 H OMe OMe CH4218 SO.sub.2 Me Q.sub.1 H Me OMe N4219 Me Q.sub.1 Me Me Me CH4220 Me Q.sub.1 Me Me OMe CH4221 Me Q.sub.1 Me OMe OMe CH4222 Me Q.sub.1 Me Me OMe N4223 Me Q.sub.1 Me OMe OMe N4224 Me H Q.sub.1 Me Me CH4225 Me H Q.sub.1 Me OMe CH4226 Me H Q.sub.1 OMe OMe CH4227 Me H Q.sub.1 Me OMe N4228 Me H Q.sub.1 OMe OMe N4229 Me Me Q.sub.1 Me OMe CH4230 Me Me Q.sub.1 OMe OMe CH4231 Me Me Q.sub.1 Me OMe N4232 Me Cl Q.sub.1 Me OMe CH4233 Me Cl Q.sub.1 OMe OMe CH4234 Me Cl Q.sub.1 Me OMe N4235 Me Br Q.sub.1 Me OMe CH4236 Me Br Q.sub.1 OMe OMe CH4237 Me Br Q.sub.1 Me OMe N4238 Me NO.sub.2 Q.sub.1 Me OMe CH4239 Me NO.sub.2 Q.sub.1 OMe OMe CH4240 Me NO.sub.2 Q.sub.1 Me OMe N4241 Et H Q.sub.1 Me OMe CH4242 Et H Q.sub.1 OMe OMe CH4243 Et H Q.sub.1 Me OMe N4244 Q.sub.2 H H Me OMe CH4245 Q.sub.2 H H OMe OMe CH4246 Q.sub.2 H H Me OMe N4247 Q.sub.2 Me H Me OMe CH4248 Q.sub.2 Me H OMe OMe CH4249 Q.sub.2 Me H Me OMe N4250 Q.sub.2 Cl H Me OMe CH4251 Q.sub.2 Cl H OMe OMe CH4252 Q.sub.2 Cl H Me OMe N4253 Q.sub.2 Br H Me OMe CH4254 Q.sub.2 Br H OMe OMe CH4255 Q.sub.2 Br H Me OMe N4256 Q.sub.2 COOMe H Me OMe CH4257 Q.sub.2 COOMe H OMe OMe CH4258 Q.sub.2 COOMe H Me OMe N4259 Q.sub.2 COOEt H Me OMe CH4260 Q.sub.2 COOEt H OMe OMe CH4261 Q.sub.2 COOEt H Me OMe N4262 Me Q.sub.2 H Me Me CH4263 Me Q.sub.2 H Me OMe CH4264 Me Q.sub.2 H OMe OMe CH4265 Me Q.sub.2 H Me OMe N4266 Me Q.sub.2 H OMe OMe N4267 COMe Q.sub.2 H Me OMe CH4268 COMe Q.sub.2 H OMe OMe CH4269 COMe Q.sub.2 H Me OMe N4270 Q.sub.3 H H Me OMe CH4271 Q.sub.3 H H OMe OMe CH4272 Q.sub.3 H H Me OMe N4273 Q.sub.3 Cl H Me OMe CH4274 Q.sub.3 Cl H OMe OMe CH4275 Q.sub.3 Cl H Me OMe N4276 Q.sub.3 COOMe H Me OMe CH4277 Q.sub.3 COOMe H OMe OMe CH4278 Q.sub.3 COOMe H Me OMe N4279 Me Q.sub.3 H Me OMe CH4280 Me Q.sub.3 H OMe OMe CH4281 Me Q.sub.3 H Me OMe N4282 Q.sub.4 H H Me OMe CH4283 Q.sub.4 H H OMe OMe CH4284 Q.sub.4 H H Me OMe N4285 Q.sub.4 Cl H Me OMe CH4286 Q.sub.4 Cl H OMe OMe CH4287 Q.sub.4 Cl H Me OMe N4288 Q.sub.4 COOMe H Me OMe CH4289 Q.sub.4 COOMe H OMe OMe CH4290 Q.sub.4 COOMe H Me OMe N4291 Me Q.sub.4 H Me OMe CH4292 Me Q.sub.4 H OMe OMe CH4293 Me Q.sub.4 H Me OMe N4294 Q.sub.5 H H Me OMe CH4295 Q.sub.5 H H OMe OMe CH4296 Q.sub.5 H H Me OMe N4297 Q.sub.5 Me H Me OMe CH4298 Q.sub.5 Me H OMe OMe CH4299 Q.sub.5 Me H Me OMe N4300 Q.sub.5 Cl H Me OMe CH4301 Q.sub.5 Cl H OMe OMe CH4302 Q.sub.5 Cl H Me OMe N4303 Q.sub.5 Br H Me OMe CH4304 Q.sub.5 Br H OMe OMe CH4305 Q.sub.5 Br H Me OMe N4306 Q.sub.5 COOMe H Me OMe CH4307 Q.sub.5 COOMe H OMe OMe CH4308 Q.sub.5 COOMe H Me OMe N4309 Q.sub.5 COOEt H Me OMe CH4310 Q.sub.5 COOEt H OMe OMe CH4311 Q.sub.5 COOEt H Me OMe N4312 Me Q.sub.5 H Me Me CH4313 Me Q.sub.5 H Me OMe CH4314 Me Q.sub.5 H OMe OMe CH4315 Me Q.sub.5 H Me OMe N4316 Me Q.sub.5 H OMe OMe N4317 COMe Q.sub.5 H Me OMe CH4318 COMe Q.sub.5 H OMe OMe CH4319 COMe Q.sub.5 H Me OMe N4320 Q.sub.6 H H Me OMe CH4321 Q.sub.6 H H OMe OMe CH4322 Q.sub.6 H H Me OMe N4323 Q.sub.6 Cl H Me OMe CH4324 Q.sub.6 Cl H OMe OMe CH4325 Q.sub.6 Cl H Me OMe N4326 Q.sub.6 COOMe H Me OMe CH4327 Q.sub.6 COOMe H OMe OMe CH4328 Q.sub.6 COOMe H Me OMe N4329 Me Q.sub.6 H Me OMe CH4330 Me Q.sub.6 H OMe OMe CH4331 Me Q.sub.6 H Me OMe N4332 Q.sub.7 Cl H Me OMe CH4333 Q.sub.7 Cl H OMe OMe CH4334 Q.sub.7 Cl H Me OMe N4335 Q.sub.7 COOMe H Me OMe CH4336 Q.sub.7 COOMe H OMe OMe CH4337 Q.sub.7 COOMe H Me OMe N4338 Me Q.sub.7 H Me OMe CH4339 Me Q.sub.7 H OMe OMe CH4340 Me Q.sub.7 H Me OMe N4341 Q.sub.8 H H Me OMe CH4342 Q.sub.8 H H OMe OMe CH4343 Q.sub.8 H H Me OMe N4344 Q.sub.8 Me H Me OMe CH4345 Q.sub.8 Me H OMe OMe CH4346 Q.sub.8 Me H Me OMe N4347 Q.sub.8 Cl H Me OMe CH4348 Q.sub.8 Cl H OMe OMe CH4349 Q.sub.8 Cl H Me OMe N4350 Q.sub.8 Br H Me OMe CH4351 Q.sub.8 Br H OMe OMe CH4352 Q.sub.8 Br H Me OMe N4353 Q.sub.8 COOMe H Me OMe CH4354 Q.sub.8 COOMe H OMe OMe CH4355 Q.sub.8 COOMe H Me OMe N4356 Q.sub.8 COOEt H Me OMe CH4357 Q.sub.8 COOEt H OMe OMe CH4358 Q.sub.8 COOEt H Me OMe N4359 Me Q.sub.8 H Me Me CH4360 Me Q.sub.8 H Me OMe CH4361 Me Q.sub.8 H OMe OMe CH4362 Me Q.sub.8 H Me OMe N4363 Me Q.sub.8 H OMe OMe N4364 COMe Q.sub.8 H Me OMe CH4365 COMe Q.sub.8 H OMe OMe CH4366 COMe Q.sub.8 H Me OMe N4367 Q.sub.9 H H Me OMe CH4368 Q.sub.9 H H OMe OMe CH4369 Q.sub.9 H H Me OMe N4370 Q.sub.9 Cl H Me OMe CH4371 Q.sub.9 Cl H OMe OMe CH4372 Q.sub.9 Cl H Me OMe N4373 Q.sub.9 COOMe H Me OMe CH4374 Q.sub.9 COOMe H OMe OMe CH4375 Q.sub.9 COOMe H Me OMe N4376 Me Q.sub.9 H Me OMe CH4377 Me Q.sub.9 H OMe OMe CH4378 Me Q.sub.9 H Me OMe N4379 Q.sub.10 H H Me OMe CH4380 Q.sub.10 H H OMe OMe CH4381 Q.sub.10 H H Me OMe N4382 Q.sub.10 Cl H Me OMe CH4383 Q.sub.10 Cl H OMe OMe CH4384 Q.sub.10 Cl H Me OMe N4385 Q.sub.10 COOMe H Me OMe CH4386 Q.sub.10 COOMe H OMe OMe CH4387 Q.sub.10 COOMe H Me OMe N4388 Me Q.sub.10 H Me OMe CH4389 Me Q.sub.10 H OMe OMe CH4390 Me Q.sub.10 H Me OMe N4391 Q.sub.11 H H Me OMe CH4392 Q.sub.11 H H OMe OMe CH4393 Q.sub.11 H H Me OMe N4394 Q.sub.11 Cl H Me OMe CH4395 Q.sub.11 Cl H OMe OMe CH4396 Q.sub.11 Cl H Me OMe N4397 Q.sub.11 COOMe H Me OMe CH4398 Q.sub.11 COOMe H OMe OMe CH4399 Q.sub.11 COOMe H Me OMe N4400 Me Q.sub.11 H Me OMe CH4401 Me Q.sub.11 H OMe OMe CH4402 Me Q.sub.11 H Me OMe N4403 Q.sub.12 H H Me OMe CH4404 Q.sub.12 H H OMe OMe CH4405 Q.sub.12 H H Me OMe N4406 Q.sub.12 Cl H Me OMe CH4407 Q.sub.12 Cl H OMe OMe CH4408 Q.sub.12 Cl H Me OMe N4409 Q.sub.12 COOMe H Me OMe CH4410 Q.sub.12 COOMe H OMe OMe CH4411 Q.sub.12 COOMe H Me OMe N4412 Me Q.sub.12 H Me OMe CH4413 Me Q.sub.12 H OMe OMe CH4414 Me Q.sub.12 H Me OMe N4415 Q.sub.13 Cl H Me OMe CH4416 Q.sub.13 Cl H OMe OMe CH4417 Q.sub.13 Cl H Me OMe N4418 Q.sub.13 COOMe H Me OMe CH4419 Q.sub.13 COOMe H OMe OMe CH4420 Q.sub.13 COOMe H Me OMe N4421 Me Q.sub.13 H Me OMe CH4422 Me Q.sub.13 H OMe OMe CH4423 Me Q.sub.13 H Me OMe N4424 Q.sub.14 H H Me OMe CH4425 Q.sub.14 H H OMe OMe CH4426 Q.sub.14 H H Me OMe N4427 Q.sub.14 Cl H Me OMe CH4428 Q.sub.14 Cl H OMe OMe CH4429 Q.sub.14 Cl H Me OMe N4430 Q.sub.14 COOMe H Me OMe CH4431 Q.sub.14 COOMe H OMe OMe CH4432 Q.sub.14 COOMe H Me OMe N4433 Me Q.sub.14 H Me OMe CH4434 Me Q.sub.14 H OMe OMe CH4435 Me Q.sub.14 H Me OMe N4436 Q.sub.15 H H Me OMe CH4437 Q.sub.15 H H OMe OMe CH4438 Q.sub.15 H H Me OMe N4439 Q.sub.15 Cl H Me OMe CH4440 Q.sub.15 Cl H OMe OMe CH4441 Q.sub.15 Cl H Me OMe N4442 Q.sub.15 COOMe H Me OMe CH4443 Q.sub.15 COOMe H OMe OMe CH4444 Q.sub.15 COOMe H Me OMe N4445 Me Q.sub.15 H Me OMe CH4446 Me Q.sub.15 H OMe OMe CH4447 Me Q.sub.15 H Me OMe N4448 Q.sub.16 H H Me OMe CH4449 Q.sub.16 H H OMe OMe CH4450 Q.sub.16 H H Me OMe N4451 Q.sub.16 Cl H Me OMe CH4452 Q.sub.16 Cl H OMe OMe CH4453 Q.sub.16 Cl H Me OMe N4454 Q.sub.16 COOMe H Me OMe CH4455 Q.sub.16 COOMe H OMe OMe CH4456 Q.sub.16 COOMe H Me OMe N4457 Me Q.sub.16 H Me OMe CH4458 Me Q.sub.16 H OMe OMe CH4459 Me Q.sub.16 H Me OMe N4460 Q.sub.17 Cl H Me OMe CH4461 Q.sub.17 Cl H OMe OMe CH4462 Q.sub.17 Cl H Me OMe N4463 Q.sub.17 COOMe H Me OMe CH4464 Q.sub.17 COOMe H OMe OMe CH4465 Q.sub.17 COOMe H Me OMe N4466 Me Q.sub.17 H Me OMe CH4467 Me Q.sub.17 H OMe OMe CH4468 Me Q.sub.17 H Me OMe N4469 Q.sub.18 H H Me OMe CH4470 Q.sub.18 H H OMe OMe CH4471 Q.sub.18 H H Me OMe N4472 Q.sub.18 Cl H Me OMe CH4473 Q.sub.18 Cl H OMe OMe CH4474 Q.sub.18 Cl H Me OMe N4475 Q.sub.18 COOMe H Me OMe CH4476 Q.sub.18 COOMe H OMe OMe CH4477 Q.sub.18 COOMe H Me OMe N4478 Me Q.sub.18 H Me OMe CH4479 Me Q.sub.18 H OMe OMe CH4480 Me Q.sub.18 H Me OMe N4481 Q.sub.19 H H Me OMe CH4482 Q.sub.19 H H OMe OMe CH4483 Q.sub.19 H H Me OMe N4484 Q.sub.19 Cl H Me OMe CH4485 Q.sub.19 Cl H OMe OMe CH4486 Q.sub.19 Cl H Me OMe N4487 Q.sub.19 COOMe H Me OMe CH4488 Q.sub.19 COOMe H OMe OMe CH4489 Q.sub.19 COOMe H Me OMe N4490 Me Q.sub.19 H Me OMe CH4491 Me Q.sub.19 H OMe OMe CH4492 Me Q.sub.19 H Me OMe N4493 Q.sub.20 H H Me OMe CH4494 Q.sub.20 H H OMe OMe CH4495 Q.sub.20 H H Me OMe N4496 Q.sub.20 Cl H Me OMe CH4497 Q.sub.20 Cl H OMe OMe CH4498 Q.sub.20 Cl H Me OMe N4499 Q.sub.20 COOMe H Me OMe CH4500 Q.sub.20 COOMe H OMe OMe CH4501 Q.sub.20 COOMe H Me OMe N4502 Me Q.sub.20 H Me OMe CH4503 Me Q.sub.20 H OMe OMe CH4504 Me Q.sub.20 H Me OMe N4505 Q.sub.21 H H Me OMe CH4506 Q.sub.21 H H OMe OMe CH4507 Q.sub.21 H H Me OMe N4508 Q.sub.21 Cl H Me OMe CH4509 Q.sub.21 Cl H OMe OMe CH4510 Q.sub.21 Cl H Me OMe N4511 Q.sub.21 COOMe H Me OMe CH4512 Q.sub.21 COOMe H OMe OMe CH4513 Q.sub.21 COOMe H Me OMe N4514 Me Q.sub.21 H Me OMe CH4515 Me Q.sub.21 H OMe OMe CH4516 Me Q.sub.21 H Me OMe N4517 Q.sub.22 H H Me OMe CH4518 Q.sub.22 H H OMe OMe CH4519 Q.sub.22 H H Me OMe N4520 Q.sub.22 Cl H Me OMe CH4521 Q.sub.22 Cl H OMe OMe CH4522 Q.sub.22 Cl H Me OMe N4523 Q.sub.22 COOMe H Me OMe CH4524 Q.sub.22 COOMe H OMe OMe CH4525 Q.sub.22 COOMe H Me OMe N4526 Me Q.sub.22 H Me OMe CH4527 Me Q.sub.22 H OMe OMe CH4528 Me Q.sub.22 H Me OMe N4529 Q.sub.23 Cl H Me OMe CH4530 Q.sub.23 Cl H OMe OMe CH4531 Q.sub.23 Cl H Me OMe N4532 Q.sub.23 COOMe H Me OMe CH4533 Q.sub.23 COOMe H OMe OMe CH4534 Q.sub.23 COOMe H Me OMe N4535 Me Q.sub.23 H Me OMe CH4536 Me Q.sub.23 H OMe OMe CH4537 Me Q.sub.23 H Me OMe N4532 Q.sub.24 H H Me OMe CH4533 Q.sub.24 H H OMe OMe CH4534 Q.sub.24 H H Me OMe N4535 Q.sub.24 Cl H Me OMe CH4536 Q.sub.24 Cl H OMe OMe CH4537 Q.sub.24 Cl H Me OMe N4538 Q.sub.24 COOMe H Me OMe CH4539 Q.sub.24 COOMe H OMe OMe CH4540 Q.sub.24 COOMe H Me OMe N4541 Me Q.sub.24 H Me OMe CH4542 Me Q.sub.24 H OMe OMe CH4543 Me Q.sub.24 H Me OMe N4544 Q.sub.25 H H Me OMe CH4545 Q.sub.25 H H OMe OMe CH4546 Q.sub.25 H H Me OMe N4547 Q.sub.25 Cl H Me OMe CH4548 Q.sub.25 Cl H OMe OMe CH4549 Q.sub.25 Cl H Me OMe N4550 Q.sub.25 COOMe H Me OMe CH4551 Q.sub.25 COOMe H OMe OMe CH4552 Q.sub.25 COOMe H Me OMe N4553 Me Q.sub.25 H Me OMe CH4554 Me Q.sub.25 H OMe OMe CH4555 Me Q.sub.25 H Me OMe N4556 Q.sub.26 Cl H Me OMe CH4557 Q.sub.26 Cl H OMe OMe CH4558 Q.sub.26 Cl H Me OMe N4559 Q.sub.26 COOMe H Me OMe CH4560 Q.sub.26 COOMe H OMe OMe CH4561 Q.sub.26 COOMe H Me OMe N4562 Me Q.sub.26 H Me OMe CH4563 Me Q.sub.26 H OMe OMe CH4564 Me Q.sub.26 H Me OMe N4565 Q.sub.27 Cl H Me OMe CH4566 Q.sub.27 Cl H OMe OMe CH4567 Q.sub.27 Cl H Me OMe N4568 Q.sub.27 COOMe H Me OMe CH4569 Q.sub.27 COOMe H OMe OMe CH4570 Q.sub.27 COOMe H Me OMe N4571 Me Q.sub.27 H Me OMe CH4572 Me Q.sub.27 H OMe OMe CH4573 Me Q.sub.27 H Me OMe N4574 Q.sub.28 H H Me OMe CH4575 Q.sub.28 H H OMe OMe CH4576 Q.sub.28 H H Me OMe N4577 Q.sub.28 Cl H Me OMe CH4578 Q.sub.28 Cl H OMe OMe CH4579 Q.sub.28 Cl H Me OMe N4580 Q.sub.28 COOMe H Me OMe CH4581 Q.sub.28 COOMe H OMe OMe CH4582 Q.sub.28 COOMe H Me OMe N4583 Me Q.sub.28 H Me OMe CH4584 Me Q.sub.28 H OMe OMe CH4585 Me Q.sub.28 H Me OMe N4586 Q.sub.29 Cl H Me OMe CH4587 Q.sub.29 Cl H OMe OMe CH4588 Q.sub.29 Cl H Me OMe N4589 Q.sub.29 COOMe H Me OMe CH4590 Q.sub.29 COOMe H OMe OMe CH4591 Q.sub.29 COOMe H Me OMe N4592 Me Q.sub.29 H Me OMe CH4593 Me Q.sub.29 H OMe OMe CH4594 Me Q.sub.29 H Me OMe N4595 Q.sub.30 Cl H Me OMe CH4596 Q.sub.30 Cl H OMe OMe CH4597 Q.sub.30 Cl H Me OMe N4598 Q.sub.30 COOMe H Me OMe CH4599 Q.sub.30 COOMe H OMe OMe CH4600 Q.sub.30 COOMe H Me OMe N4601 Me Q.sub.30 H Me OMe CH4602 Me Q.sub.30 H OMe OMe CH4603 Me Q.sub.30 H Me OMe N4604 Q.sub.31 Cl H Me OMe CH4605 Q.sub.31 Cl H OMe OMe CH4606 Q.sub.31 Cl H Me OMe N4607 Q.sub.31 COOMe H Me OMe CH4608 Q.sub.31 COOMe H OMe OMe CH4609 Q.sub.31 COOMe H Me OMe N4610 Me Q.sub.31 H Me OMe CH4611 Me Q.sub.31 H OMe OMe CH4612 Me Q.sub.31 H Me OMe N4613 Q.sub.32 H H Me OMe CH4614 Q.sub.32 H H OMe OMe CH4615 Q.sub.32 H H Me OMe N4616 Q.sub.32 Me H Me OMe CH4617 Q.sub.32 Me H OMe OMe CH4618 Q.sub.32 Me H Me OMe N4619 Q.sub.32 Cl H Me OMe CH4620 Q.sub.32 Cl H OMe OMe CH4621 Q.sub.32 Cl H Me OMe N4622 Q.sub.32 Br H Me OMe CH4623 Q.sub.32 Br H OMe OMe CH4624 Q.sub.32 Br H Me OMe N4625 Q.sub.32 COOMe H Me OMe CH4626 Q.sub.32 COOMe H OMe OMe CH4627 Q.sub.32 COOMe H Me OMe N4628 Q.sub.32 COOEt H Me OMe CH4629 Q.sub.32 COOEt H OMe OMe CH4630 Q.sub.32 COOEt H Me OMe N4631 Me Q.sub.32 H Me Me CH4632 Me Q.sub.32 H Me OMe CH4633 Me Q.sub.32 H OMe OMe CH4634 Me Q.sub.32 H Me OMe N4635 Me Q.sub.32 H OMe OMe N4636 COMe Q.sub.32 H Me OMe CH4637 COMe Q.sub.32 H OMe OMe CH4638 COMe Q.sub.32 H Me OMe N4639 Q.sub.33 H H Me OMe CH4640 Q.sub.33 H H OMe OMe CH4641 Q.sub.33 H H Me OMe N4642 Q.sub.33 Cl H Me OMe CH4643 Q.sub.33 Cl H OMe OMe CH4644 Q.sub.33 Cl H Me OMe N4645 Q.sub.33 COOMe H Me OMe CH4646 Q.sub.33 COOMe H OMe OMe CH4647 Q.sub.33 COOMe H Me OMe N4648 Me Q.sub.33 H Me OMe CH4649 Me Q.sub.33 H OMe OMe CH4650 Me Q.sub.33 H Me OMe N4651 Q.sub.34 H H Me OMe CH4652 Q.sub.34 H H OMe OMe CH4653 Q.sub.34 H H Me OMe N4654 Q.sub.34 Cl H Me OMe CH4655 Q.sub.34 Cl H OMe OMe CH4656 Q.sub.34 Cl H Me OMe N4657 Q.sub.34 COOMe H Me OMe CH4658 Q.sub.34 COOMe H OMe OMe CH4659 Q.sub.34 COOMe H Me OMe N4660 Me Q.sub.34 H Me OMe CH4661 Me Q.sub.34 H OMe OMe CH4662 Me Q.sub.34 H Me OMe N4663 Q.sub.35 H H Me OMe CH4664 Q.sub.35 H H OMe OMe CH4665 Q.sub.35 H H Me OMe N4666 Q.sub.35 Cl H Me OMe CH4667 Q.sub.35 Cl H OMe OMe CH4668 Q.sub.35 Cl H Me OMe N4669 Q.sub.35 COOMe H Me OMe CH4670 Q.sub.35 COOMe H OMe OMe CH4671 Q.sub.35 COOMe H Me OMe N4672 Me Q.sub.35 H Me OMe CH4673 Me Q.sub.35 H OMe OMe CH4674 Me Q.sub.35 H Me OMe N4675 Q.sub.36 Cl H Me OMe CH4676 Q.sub.36 Cl H OMe OMe CH4677 Q.sub.36 Cl H Me OMe N4678 Q.sub.36 COOMe H Me OMe CH4679 Q.sub.36 COOMe H OMe OMe CH4680 Q.sub.36 COOMe H Me OMe N4681 Me Q.sub.36 H Me OMe CH4682 Me Q.sub.36 H OMe OMe CH4683 Me Q.sub.36 H Me OMe N4684 Q.sub.37 H H Me OMe CH4685 Q.sub.37 H H OMe OMe CH4686 Q.sub.37 H H Me OMe N4687 Q.sub.37 Cl H Me OMe CH4688 Q.sub.37 Cl H OMe OMe CH4689 Q.sub.37 Cl H Me OMe N4690 Q.sub.37 COOMe H Me OMe CH4691 Q.sub.37 COOMe H OMe OMe CH4692 Q.sub.37 COOMe H Me OMe N4693 Me Q.sub.37 H Me OMe CH4694 Me Q.sub.37 H OMe OMe CH4695 Me Q.sub.37 H Me OMe N4696 Q.sub.38 H H Me OMe CH4697 Q.sub.38 H H OMe OMe CH4698 Q.sub.38 H H Me OMe N4699 Q.sub.38 Cl H Me OMe CH4700 Q.sub.38 Cl H OMe OMe CH4701 Q.sub.38 Cl H Me OMe N4702 Q.sub.38 COOMe H Me OMe CH4703 Q.sub.38 COOMe H OMe OMe CH4704 Q.sub.38 COOMe H Me OMe N4705 Me Q.sub.38 H Me OMe CH4706 Me Q.sub.38 H OMe OMe CH4707 Me Q.sub.38 H Me OMe N4708 Q.sub.39 H H Me OMe CH4709 Q.sub.39 H OMe OMe CH4710 Q.sub.39 H H Me OMe N4711 Q.sub.39 Cl H Me OMe CH4712 Q.sub.39 Cl H OMe OMe CH4713 Q.sub.39 Cl H Me OMe N4714 Q.sub.39 COOMe H Me OMe CH4715 Q.sub.39 COOMe H OMe OMe CH4716 Q.sub.39 COOMe H Me OMe N4717 Me Q.sub.39 H Me OMe CH4718 Me Q.sub.39 H OMe OMe CH4719 Me Q.sub.39 H Me OMe N4720 Q.sub.40 Cl H Me OMe CH4721 Q.sub.40 Cl H OMe OMe CH4722 Q.sub.40 Cl H Me OMe N4723 Q.sub.40 COOMe H Me OMe CH4724 Q.sub.40 COOMe H OMe OMe CH4725 Q.sub.40 COOMe H Me OMe N4726 Me Q.sub.40 H Me OMe CH4727 Me Q.sub.40 H OMe OMe CH4728 Me Q.sub.40 H Me OMe N4729 Q.sub.41 H H Me OMe CH4730 Q.sub.41 H H OMe OMe CH4731 Q.sub.41 H H Me OMe N4732 Q.sub.41 Cl H Me OMe CH4733 Q.sub.41 Cl H OMe OMe CH4734 Q.sub.41 Cl H Me OMe N4735 Q.sub.41 COOMe H Me OMe CH4736 Q.sub.41 COOMe H OMe OMe CH4737 Q.sub.41 COOMe H Me OMe N4738 Me Q.sub.41 H Me OMe CH4739 Me Q.sub.41 H OMe OMe CH4740 Me Q.sub.41 H Me OMe N4741 Q.sub.42 H H Me OMe CH4742 Q.sub.42 H H OMe OMe CH4743 Q.sub.42 H H Me OMe N4744 Q.sub.42 Cl H OMe OMe CH4745 Q.sub.42 Cl H OMe OMe CH4746 Q.sub.42 Cl H Me OMe N4747 Q.sub.42 COOMe H Me OMe CH4748 Q.sub.42 COOMe H OMe OMe CH4749 Q.sub.42 COOMe H Me OMe N4750 Me Q.sub.42 H Me OMe CH4751 Me Q.sub.42 H OMe OMe CH4752 Me Q.sub.42 H Me OMe N4753 Q.sub.43 H H Me OMe CH4754 Q.sub.43 H H OMe OMe CH4755 Q.sub.43 H H Me OMe N4756 Q.sub.43 Cl H Me OMe CH4757 Q.sub.43 Cl H OMe OMe CH4758 Q.sub.43 Cl H Me OMe N4759 Q.sub.43 COOMe H Me OMe CH4760 Q.sub.43 COOMe H OMe OMe CH4761 Q.sub.43 COOMe H Me OMe N4762 Me Q.sub.43 H Me OMe CH4763 Me Q.sub.43 H OMe OMe CH4764 Me Q.sub.43 H Me OMe N4765 Q.sub.44 Cl H Me OMe CH4766 Q.sub.44 Cl H OMe OMe CH4767 Q.sub.44 Cl H Me OMe N4768 Q.sub.44 COOMe H Me OMe CH4769 Q.sub. 44 COOMe H OMe OMe CH4770 Q.sub.44 COOMe H Me OMe N4771 Me Q.sub.44 H Me OMe CH4772 Me Q.sub.44 H OMe OMe CH4773 Me Q.sub.44 H Me OMe N4774 Q.sub.45 H H Me OMe CH4775 Q.sub.45 H H OMe OMe CH4776 Q.sub.45 H H Me OMe N4777 Q.sub.45 Me H Me OMe CH4778 Q.sub.45 Me H OMe OMe CH4779 Q.sub.45 Me H Me OMe N4780 Q.sub.45 Cl H Me OMe CH4781 Q.sub.45 Cl H OMe OMe CH4782 Q.sub.45 Cl H Me OMe N4783 Q.sub.45 Br H Me OMe CH4784 Q.sub.45 Br H OMe OMe CH4785 Q.sub.45 Br H Me OMe N4786 Q.sub.45 COOMe H Me OMe CH4787 Q.sub.45 COOMe H OMe OMe CH4788 Q.sub.45 COOMe H Me OMe N4789 Q.sub.45 COOEt H Me OMe CH4790 Q.sub.45 COOEt H OMe OMe CH4791 Q.sub.45 COOEt H Me OMe N4792 Me Q.sub.45 H Me Me CH4793 Me Q.sub.45 H Me OMe CH4794 Me Q.sub.45 H OMe OMe CH4795 Me Q.sub.45 H Me OMe N4796 Me Q.sub.45 H OMe OMe N4797 COOMe Q.sub.45 H Me OMe CH4798 COOMe Q.sub.45 H OMe OMe CH4799 COOMe Q.sub.45 H Me OMe N4800 Q.sub.46 H H Me OMe CH4801 Q.sub.46 H H OMe OMe CH4802 Q.sub.46 H H Me OMe N4803 Q.sub.46 Cl H Me OMe CH4804 Q.sub.46 Cl H OMe OMe CH4805 Q.sub.46 Cl H Me OMe N4806 Q.sub.46 COOMe H Me OMe CH4807 Q.sub.46 COOMe H OMe OMe CH4808 Q.sub.46 COOMe H Me OMe N4809 Me Q.sub.46 H Me OMe CH4810 Me Q.sub.46 H Me OMe CH4811 Me Q.sub.46 H Me OMe N4812 Q.sub.47 H H Me OMe CH4813 Q.sub.47 H H OMe OMe CH4814 Q.sub.47 H H Me OMe N4815 Q.sub.47 Cl H Me OMe CH4816 Q.sub.47 Cl H OMe OMe CH4817 Q.sub.47 Cl H Me OMe N4818 Q.sub.47 COOMe H Me OMe CH4819 Q.sub. 47 COOMe H OMe OMe CH4820 Q.sub.47 COOMe H Me OMe N4821 Me Q.sub.47 H Me OMe CH4822 Me Q.sub.47 H OMe OMe CH4823 Me Q.sub.47 H Me OMe N4824 Q.sub.48 H Me OMe CH4825 Q.sub.48 H OMe OMe CH4826 Q.sub.48 H Me OMe N4827 Q.sub.48 Cl Me OMe CH4828 Q.sub.48 Cl OMe OMe CH4829 Q.sub.48 H Me OMe N4830 Q.sub.48 COOMe Me OMe CH4831 Q.sub.48 COOMe OMe OMe CH4832 Q.sub.48 COOMe Me OMe N4833 Me Q.sub.48 H Me OMe CH4834 Me Q.sub.48 H OMe OMe CH4835 Me Q.sub.48 H Me OMe N4836 Q.sub.49 H H Me OMe CH4837 Q.sub.49 H H OMe OMe CH4838 Q.sub.49 H H Me OMe N4839 Q.sub.49 Cl H Me OMe CH4840 Q.sub.49 Cl H OMe OMe CH4841 Q.sub.49 Cl H Me OMe N4842 Q.sub.49 COOMe H Me OMe CH4843 Q.sub.49 COOMe H OMe OMe CH4844 Q.sub.49 COOMe H Me OMe N4845 Me Q.sub. 49 H Me OMe CH4846 Me Q.sub.49 H OMe OMe CH4847 Me Q.sub.49 H Me OMe N4848 Q.sub.50 H H Me OMe CH4849 Q.sub.50 H H OMe OMe CH4850 Q.sub.50 H H Me OMe N4851 Q.sub.50 Cl H Me OMe CH4852 Q.sub.50 Cl H OMe OMe CH4853 Q.sub.50 Cl H Me OMe N4854 Q.sub.50 COOMe H Me OMe CH4855 Q.sub.50 COOMe H OMe OMe CH4856 Q.sub.50 COOMe H Me OMe N4857 Me Q.sub.50 H Me OMe CH4858 Me Q.sub.50 H OMe OMe CH4859 Me Q.sub.50 H Me OMe N4860 Q.sub.51 H H Me OMe CH4861 Q.sub.51 H H OMe OMe CH4862 Q.sub.51 H H Me OMe N4863 Q.sub.51 Cl H Me OMe CH4864 Q.sub.51 Cl H OMe OMe CH4865 Q.sub.51 Cl H Me OMe N4866 Q.sub.51 COOMe H Me OMe CH4867 Q.sub.51 COOMe H OMe OMe CH4868 Q.sub.51 COOMe H Me OMe N4869 Me Q.sub.51 H Me OMe CH4870 Me Q.sub. 51 H OMe OMe CH4871 Me Q.sub.51 H Me OMe N4872 Q.sub.52 Cl H Me OMe CH4873 Q.sub.52 Cl H OMe OMe CH4874 Q.sub.52 Cl H Me OMe N4875 Q.sub.52 COOMe H Me OMe CH4876 Q.sub.52 COOMe H OMe OMe CH4877 Q.sub.52 COOMe H Me OMe N4878 Me Q.sub.52 H Me OMe CH4879 Me Q.sub.52 H OMe OMe CH4880 Me Q.sub.52 H Me OMe N4881 Q.sub.53 Cl H Me OMe CH4882 Q.sub.53 Cl H OMe OMe CH4883 Q.sub.53 Cl H Me OMe N4884 Q.sub.53 COOMe H Me OMe CH4885 Q.sub.53 COOMe H OMe OMe CH4886 Q.sub.53 COOMe H Me OMe N4887 Me Q.sub.53 H Me OMe CH4888 Me Q.sub.53 H OMe OMe CH4889 Me Q.sub.53 H Me OMe N4890 Q.sub.54 H H Me OMe CH4891 Q.sub.54 H H OMe OMe CH4892 Q.sub.54 H H Me OMe N4893 Q.sub.54 Cl H Me OMe CH4894 Q.sub.54 Cl H OMe OMe CH4895 Q.sub.54 Cl H Me OMe N4896 Q.sub.54 COOMe H Me OMe CH4897 Q.sub.54 COOMe H OMe OMe CH4898 Q.sub.54 COOMe H Me OMe N4899 Me Q.sub.54 H Me OMe CH4900 Me Q.sub.54 H OMe OMe CH4901 Me Q.sub.54 H Me OMe N4902 Q.sub.55 H H Me OMe CH4903 Q.sub.55 H H OMe OMe CH4904 Q.sub.55 H H Me OMe N4905 Q.sub.55 Cl H Me OMe CH4906 Q.sub.55 Cl H OMe OMe CH4907 Q.sub.55 Cl H Me OMe N4908 Q.sub.55 COOMe H Me OMe CH4909 Q.sub.55 COOMe H OMe OMe CH4910 Q.sub.55 COOMe H Me OMe N4911 Me Q.sub.55 H Me OMe CH4912 Me Q.sub.55 H OMe OMe CH4913 Me Q.sub.55 H Me OMe N4914 Q.sub.56 H H Me OMe CH4915 Q.sub.56 H H OMe OMe CH4916 Q.sub.56 H H Me OMe N4917 Q.sub.56 Cl H Me OMe CH4918 Q.sub.56 Cl H OMe OMe CH4919 Q.sub.56 Cl H Me OMe N4920 Q.sub.56 COOMe H Me OMe CH4921 Q.sub.56 COOMe H OMe OMe CH4922 Q.sub.56 COOMe H Me OMe N4923 Me Q.sub.56 H Me OMe CH4924 Me Q.sub.56 H OMe OMe CH4925 Me Q.sub.56 H Me OMe N4926 Q.sub.57 Cl H Me OMe CH4927 Q.sub.57 Cl H OMe OMe CH4928 Q.sub.57 Cl H Me OMe N4929 Q.sub.57 COOMe H Me OMe CH4930 Q.sub.57 COOMe H OMe OMe CH4931 Q.sub.57 COOMe H Me OMe N4932 Me Q.sub.57 H Me OMe CH4933 Me Q.sub.57 H OMe OMe CH4934 Me Q.sub.57 H Me OMe N4935 Q.sub.58 Cl H Me OMe CH4936 Q.sub.58 Cl H OMe OMe CH4937 Q.sub.58 Cl H Me OMe N4938 Q.sub.58 COOMe H Me OMe CH4939 Q.sub.58 COOMe H OMe OMe CH4940 Q.sub.58 COOMe H Me OMe N4941 Me Q.sub.58 H Me OMe CH4942 Me Q.sub.58 H OMe OMe CH4943 Me Q.sub.58 H Me OMe N4944 Q.sub.59 H H Me OMe CH4945 Q.sub.59 H H OMe OMe CH4946 Q.sub.59 H H Me OMe N4947 Q.sub.59 Me H Me OMe CH4948 Q.sub.59 Me H OMe OMe CH4949 Q.sub.59 Me H Me OMe N4950 Q.sub.59 Cl H Me OMe CH4951 Q.sub.59 Cl H OMe OMe CH4952 Q.sub.59 Cl H Me OMe N4953 Q.sub.59 Br H Me OMe CH4954 Q.sub.59 Br H OMe OMe CH4955 Q.sub.59 Br H Me OMe N4956 Q.sub.59 COOMe H Me OMe CH4957 Q.sub.59 COOMe H Me OMe N4958 Q.sub.59 COOMe H Me OMe N4959 Q.sub.59 COOEt H Me OMe CH4960 Q.sub.59 COOEt H OMe OMe CH4961 Q.sub.59 COOEt H Me OMe N4962 Me Q.sub.59 H Me Me CH4963 Me Q.sub.59 H Me OMe CH4964 Me Q.sub.59 H OMe OMe CH4965 Me Q.sub.59 H Me OMe N4966 Me Q.sub.59 H Me OMe N4967 COMe Q.sub.59 H Me OMe CH4968 COMe Q.sub.59 H OMe OMe CH4969 COMe Q.sub.59 H Me OMe N4970 Q.sub.60 H H Me OMe CH4971 Q.sub.60 H H OMe OMe CH4972 Q.sub.60 H H Me OMe N4973 Q.sub.60 Cl H Me OMe CH4974 Q.sub.60 Cl H OMe OMe CH4975 Q.sub.60 Cl H Me OMe N4976 Q.sub.60 COOMe H Me OMe CH4977 Q.sub.60 COOMe H OMe OMe CH4978 Q.sub.60 COOMe H Me OMe N4979 Me Q.sub.60 H Me OMe CH4980 Me Q.sub.60 H OMe OMe CH4981 Me Q.sub.60 H Me OMe N4970 Q.sub.61 H H Me OMe CH4971 Q.sub.61 H H OMe OMe CH4972 Q.sub.61 H H Me OMe N4973 Q.sub.61 Cl H Me OMe CH4974 Q.sub.61 Cl H OMe OMe CH4975 Q.sub.61 Cl H Me OMe N4976 Q.sub.61 COOMe H Me OMe CH4977 Q.sub.61 COOMe H OMe OMe CH4978 Q.sub.61 COOMe H Me OMe N4979 Me Q.sub.61 H Me OMe CH4980 Me Q.sub.61 H OMe OMe CH4981 Me Q.sub.61 H Me OMe N4982 Q.sub.62 H H Me OMe CH4983 Q.sub.62 H H OMe OMe CH4984 Q.sub.62 H H Me OMe N4985 Q.sub.62 Cl H Me OMe CH4986 Q.sub.62 Cl H OMe OMe CH4987 Q.sub.62 Cl H Me OMe N4988 Q.sub.62 COOMe H Me OMe CH4989 Q.sub.62 COOMe H OMe OMe CH4990 Q.sub.62 COOMe H Me OMe N4991 Me Q.sub.62 H Me OMe CH4992 Me Q.sub.62 H OMe OMe CH4993 Me Q.sub.62 H Me OMe N4994 Q.sub.63 Cl H Me OMe CH4995 Q.sub.63 Cl H OMe OMe CH4996 Q.sub.63 Cl H Me OMe N4997 Q.sub.63 COOMe H Me OMe CH4998 Q.sub.63 COOMe H OMe OMe CH4999 Q.sub.63 COOMe H Me OMe N5000 Me Q.sub.63 H Me OMe CH5001 Me Q.sub.63 H OMe OMe CH5002 Me Q.sub.63 H Me OMe N5003 Q.sub.64 Cl H Me OMe CH5004 Q.sub.64 Cl H OMe OMe CH5005 Q.sub.64 Cl H Me OMe N5006 Q.sub.64 COOMe H Me OMe CH5007 Q.sub.64 COOMe H OMe OMe CH5008 Q.sub.64 COOMe H Me OMe N5009 Me Q.sub.64 H Me OMe CH5010 Me Q.sub.64 H OMe OMe CH5011 Me Q.sub.64 H Me OMe N5012 Q.sub.65 H H Me OMe CH5013 Q.sub.65 H H OMe OMe CH5014 Q.sub.65 H H Me OMe N5015 Q.sub.65 Cl H Me OMe CH5016 Q.sub.65 Cl H OMe OMe CH5017 Q.sub.65 Cl H Me OMe N5018 Q.sub.65 COOMe H Me OMe CH5019 Q.sub.65 COOMe H OMe OMe CH5020 Q.sub.65 COOMe H Me OMe N5021 Me Q.sub.65 H Me OMe CH5022 Me Q.sub.65 H OMe OMe CH5023 Me Q.sub.65 H Me OMe N5024 Q.sub.66 Cl H Me OMe CH5025 Q.sub.66 Cl H OMe OMe CH5026 Q.sub.66 Cl H Me OMe N5027 Q.sub.66 COOMe H Me OMe CH5028 Q.sub.66 COOMe H OMe OMe CH5029 Q.sub.66 COOMe H Me OMe N5030 Me Q.sub.66 H Me OMe CH5031 Me Q.sub.66 H OMe OMe CH5032 Me Q.sub.66 H Me OMe N5033 Q.sub. 67 Cl H Me OMe CH5034 Q.sub.67 Cl H OMe OMe CH5035 Q.sub.67 Cl H Me OMe N5036 Q.sub.67 COOMe H Me OMe CH5037 Q.sub.67 COOMe H OMe OMe CH5038 Q.sub.67 COOMe H Me OMe N5039 Me Q.sub.67 H Me OMe CH5040 Me Q.sub.67 H OMe OMe CH5041 Me Q.sub.67 H Me OMe N5042 Q.sub.68 Cl H Me OMe CH5043 Q.sub.68 Cl H OMe OMe CH5044 Q.sub.68 Cl H Me OMe N5045 Q.sub.68 COOMe H Me OMe CH5046 Q.sub.68 COOMe H OMe OMe CH5047 Q.sub.68 COOMe H Me OMe N5048 Me Q.sub.68 H Me OMe CH5049 Me Q.sub.68 H OMe OMe CH5050 Me Q.sub.68 H Me OMe N5051 Q.sub.69 Cl H Me OMe CH5052 Q.sub.69 Cl h OEM OMe CH5053 Q.sub.69 CL H Me OMe N5054 Q.sub.69 COOMe H OMe OMe CH5055 Q.sub.69 COOMe H OMe OMe CH5056 Q.sub.69 COOMe H Me OMe N5057 Me Q.sub.69 H Me OMe CH5058 Me Q.sub. 69 H OMe OMe CH5059 Me Q.sub.69 H Me OMe N5060 Q.sub.70 H H Me OMe CH5061 Q.sub.70 H H OMe OMe CH5062 Q.sub.70 H H Me OMe N5063 Q.sub.70 Cl H Me OMe CH5064 Q.sub.70 Cl H OMe OMe CH5065 Q.sub.70 Cl H Me OMe N5066 Q.sub.70 COOMe H Me OMe CH5067 Q.sub.70 COOMe H OMe OMe CH5068 Q.sub.70 COOMe H Me OMe N5069 Me Q.sub.70 H Me OMe CH5070 Me Q.sub.70 H OMe OMe CH5071 Me Q.sub.70 H Me OMe N5072 Q.sub.71 Cl H Me OMe CH5073 Q.sub.71 Cl H OMe OMe CH5074 Q.sub.71 Cl H Me OMe N5075 Q.sub.71 COOMe H Me OMe CH5076 Q.sub.71 COOMe H OMe OMe CH5077 Q.sub.71 COOMe H Me OMe N5078 Me Q.sub.71 H Me OMe CH5079 Me Q.sub.71 H OMe OMe CH5080 Me Q.sub.71 H Me OMe N5081 Q.sub.72 Cl H Me OMe CH5082 Q.sub.72 Cl H OMe OMe CH5083 Q.sub.72 Cl H Me OMe N5084 Q.sub.72 COOMe H Me OMe CH5085 Q.sub.72 COOMe H OMe OMe CH5086 Q.sub.72 COOMe H Me OMe N5087 Me Q.sub.72 H Me OMe CH5088 Me Q.sub.72 H OMe OMe CH5089 Me Q.sub.72 H Me OMe N5090 Q.sub.73 Cl H Me OMe CH5091 Q.sub.73 Cl H OMe OMe CH5092 Q.sub.73 Cl H Me OMe N5093 Q.sub.73 COOMe H Me OMe CH5094 Q.sub.73 COOMe H OMe OMe CH5095 Q.sub.73 COOMe H Me OMe N5096 Me Q.sub.73 H Me OMe CH5097 Me Q.sub.73 H OMe OMe CH5098 Me Q.sub.73 H Me OMe N5099 Q.sub.74 Cl H Me OMe CH5100 Q.sub.74 Cl H OMe OMe CH5101 Q.sub.74 Cl H Me OMe N5102 Q.sub.74 COOMe H Me OMe CH5103 Q.sub.74 COOMe H OMe OMe CH5104 Q.sub.74 COOMe H Me OMe N5105 Me Q.sub.74 H Me OMe CH5106 Me Q.sub.74 H OMe OMe CH5107 Me Q.sub.74 H Me OMe N5108 Q.sub.75 Cl H Me OMe CH5109 Q.sub.75 Cl H OMe OMe CH5110 Q.sub.75 Cl H Me OMe N5111 Q.sub.75 CL H Me OMe N5112 Q.sub.75 COOMe H OMe OMe CH5113 Q.sub.75 COOMe H Me OMe N5114 Me Q.sub.75 H Me OMe CH5115 Me Q.sub.75 H OMe OMe CH5116 Me Q.sub.75 H Me OMe N5117 76 Cl H Me OMe CH5118 Q.sub.76 Cl H OMe OMe CH5119 Q.sub.76 Cl H Me OMe N5120 Q.sub.76 COOMe H Me OMe CH5121 Q.sub.76 COOMe H OMe OMe CH5122 Q.sub.76 COOMe H Me OMe N5123 Me Q.sub.76 H Me OMe CH5124 Me Q.sub.76 H OMe OMe CH5125 Me Q.sub.76 H Me OMe N5720 Q.sub.77 Cl H Me OMe CH5721 Q.sub.77 Cl H OMe OMe CH5722 Q.sub.77 Cl H Me OMe N5723 Q.sub.77 COOMe H Me OMe CH5724 Q.sub.77 COOMe H OMe OMe CH5725 Q.sub.77 COOMe H Me OMe N5726 Me Q.sub.77 H Me OMe CH5727 Me Q.sub.77 H OMe OMe CH5728 Me Q.sub.77 H Me OMe N5729 Q.sub.78 H H Me OMe CH5730 Q.sub.78 H H OMe OMe CH5731 Q.sub.78 H H Me OMe N5732 Q.sub.78 Me H Me OMe CH5733 Q.sub.78 Me H OMe OMe CH5734 Q.sub.78 Me H Me OMe N5735 Q.sub.78 Cl H Me OMe CH5736 Q.sub.78 Cl H OMe OMe CH5737 Q.sub.78 Cl H Me OMe N5738 Q.sub.78 Br H Me OMe CH5739 Q.sub.78 Br H OMe OMe CH5740 Q.sub.78 Br H Me OMe N5741 Q.sub.78 COOMe H Me OMe CH5742 Q.sub.78 COOMe H OMe OMe CH5743 Q.sub.78 COOMe H Me OMe N5744 Q.sub.78 COOEt H Me OMe CH5745 Q.sub.78 COOEt H OMe OMe CH5746 Q.sub.78 COOEt H Me OMe N5747 Me Q.sub.78 H Me Me CH5748 Me Q.sub.78 H Me OMe CH5749 Me Q.sub.78 H OMe OMe CH5750 Me Q.sub.78 H Me OMe N5751 Me Q.sub.78 H OMe OMe N5752 COOMe Q.sub.78 H Me OMe CH5753 COOMe Q.sub.78 H OMe OMe CH5754 COOMe Q.sub.78 H Me OMe N5755 Q.sub.79 H H Me OMe CH5756 Q.sub.79 H H OMe OMe CH5757 Q.sub.79 H H Me OMe N5758 Q.sub.79 Me H Me OMe CH5759 Q.sub.79 Me H OMe OMe CH5760 Q.sub.79 Me H Me OMe N5761 Q.sub.79 Cl H Me OMe CH5762 Q.sub.79 Cl H OMe OMe CH5763 Q.sub.79 Cl H Me OMe N5764 Q.sub.79 Br H Me OMe CH5765 Q.sub.79 Br H OMe OMe CH5766 Q.sub.79 Br H Me OMe N5767 Q.sub.79 COOMe H Me OMe CH5768 Q.sub.79 COOMe H OMe OMe CH5769 Q.sub.79 COOMe H Me OMe N5770 Q.sub.79 COOEt H Me OMe CH5771 Q.sub.79 COOEt H OMe OMe CH5772 Q.sub.79 COOEt H Me OMe N5773 Me Q.sub.79 H Me Me CH5774 Me Q.sub.79 H Me OMe CH5775 Me Q.sub.79 H OMe OMe CH5776 Me Q.sub.79 H Me OMe N5777 Me Q.sub.79 H OMe OMe N5778 COOMe Q.sub.79 H Me OMe CH5779 COOMe Q.sub.79 H OMe OMe CH5780 COOMe Q.sub.79 H Me OMe N5781 Q.sub.80 H H Me OMe CH5782 Q.sub.80 H H OMe OMe CH5783 Q.sub.80 H H Me OMe N5784 Q.sub.80 Cl H Me OMe CH5785 Q.sub.80 Cl H OMe OMe CH5786 Q.sub.80 Cl H Me OMe N5787 Q.sub.80 COOMe H Me OMe CH5788 Q.sub.80 COOMe H OMe OMe CH5789 Q.sub.80 COOMe H Me OMe N5790 Me Q.sub.80 H Me OMe CH5791 Me Q.sub.80 H OMe OMe CH5792 Me Q.sub.80 H Me OMe N5793 Q.sub.81 Cl H Me OMe CH5794 Q.sub.81 Cl H OMe OMe CH5795 Q.sub.81 Cl H Me OMe N5796 Q.sub.81 COOMe H Me OMe CH5797 Q.sub.81 COOMe H OMe OMe CH5798 Q.sub.81 COOMe H Me OMe N5799 Me Q.sub.81 H Me OMe CH5800 Me Q.sub.81 H OMe OMe CH5801 Me Q.sub.81 H Me OMe N5802 Q.sub.82 Cl H Me OMe CH5803 Q.sub.82 Cl H OMe OMe CH5804 Q.sub.82 Cl H Me OMe N5805 Q.sub.82 COOMe H OMe OMe CH5806 Q.sub.82 COOMe H OMe OMe CH5807 Q.sub.82 COOMe H Me OMe N5808 Me Q.sub.82 H Me OMe CH5809 Me Q.sub.82 H OMe OMe CH5810 Me Q.sub.82 H Me OMe N5811 Q.sub.83 Cl H Me OMe CH5812 Q.sub.83 Cl H OMe OMe CH5813 Q.sub.83 Cl H Me OMe N5814 Q.sub.83 COOMe H Me OMe CH5815 Q.sub.83 COOMe H OMe OMe CH5816 Q.sub.83 COOMe H Me OMe N5817 Me Q.sub.83 H Me OMe CH5818 Me Q.sub.83 H OMe OMe CH5819 Me Q.sub.83 H Me OMe N6551 Q.sub.16 COOEt H OMe OMe CH4677 Q.sub.36 Cl H Me OMe N4678 Q.sub.36 COOMe H Me OMe CH4679 Q.sub.36 COOMe H OMe OMe CH4680 Q.sub.36 COOMe H Me OMe N4681 Me Q.sub.36 H Me OMe CH4682 Me Q.sub.36 H OMe OMe CH4683 Me Q.sub.36 H Me OMe N4684 Q.sub.37 H H Me OMe CH4685 Q.sub.37 H H OMe OMe CH4686 Q.sub.37 H H Me OMe N4687 Q.sub.37 Cl H Me OMe CH4688 Q.sub.37 Cl H OMe OMe CH4689 Q.sub.37 Cl H Me OMe N4690 Q.sub.37 COOMe H Me OMe CH4691 Q.sub.37 COOMe H OMe OMe CH4692 Q.sub.37 COOMe H Me OMe N4693 Me Q.sub.37 H Me OMe CH4694 Me Q.sub.37 H OMe OMe CH4695 Me Q.sub.37 H Me OMe N4696 Q.sub.38 H H Me OMe CH4697 Q.sub.38 H H OMe OMe CH4698 Q.sub.38 H H Me OMe N4699 Q.sub.38 Cl H Me OMe CH4700 Q.sub.38 Cl H OMe OMe CH4701 Q.sub.38 Cl H Me OMe N4702 Q.sub.38 COOMe H Me OMe CH4703 Q.sub.38 COOMe H OMe OMe CH4704 Q.sub.38 COOMe H Me OMe N4705 Me Q.sub.38 H Me OMe CH4706 Me Q.sub.38 H OMe OMe CH4707 Me Q.sub.38 H Me OMe N4708 Q.sub.39 H H Me OMe CH4709 Q.sub.39 H OMe OMe CH4710 Q.sub.39 H H Me OMe N4711 Q.sub.39 Cl H Me OMe CH4712 Q.sub.39 Cl H OMe OMe CH4713 Q.sub.39 Cl H Me OMe N4714 Q.sub.39 COOMe H Me OMe CH4715 Q.sub.39 COOMe H OMe OMe CH4716 Q.sub.39 COOMe H Me OMe N4717 Me Q.sub.39 H Me OMe CH4718 Me Q.sub.39 H OMe OMe CH4719 Me Q.sub.39 H Me OMe N4720 Q.sub.40 Cl H Me OMe CH4721 Q.sub.40 Cl H OMe OMe CH4722 Q.sub.40 Cl H Me OMe N4723 Q.sub.40 COOMe H Me OMe CH4724 Q.sub.40 COOMe H OMe OMe CH4725 Q.sub.40 COOMe H Me OMe N4726 Me Q.sub.40 H Me OMe CH4727 Me Q.sub.40 H OMe OMe CH4728 Me Q.sub.40 H Me OMe N4729 Q.sub.41 H H Me OMe CH4730 Q.sub.41 H H OMe OMe CH4731 Q.sub.41 H H Me OMe N4732 Q.sub.41 Cl H Me OMe CH4733 Q.sub.41 Cl H OMe OMe CH4734 Q.sub.41 Cl H Me OMe N4735 Q.sub.41 COOMe H Me OMe CH4736 Q.sub.41 COOMe H OMe OMe CH4737 Q.sub.41 COOMe H Me OMe N4738 Me Q.sub.41 H Me OMe CH4739 Me Q.sub.41 H OMe OMe CH4740 Me Q.sub.41 H Me OMe N4741 Q.sub.42 H H Me OMe CH4742 Q.sub.42 H H OMe OMe CH4743 Q.sub.42 H H Me OMe N4744 Q.sub.42 Cl H OMe OMe CH4745 Q.sub.42 Cl H OMe OMe CH4746 Q.sub.42 Cl H Me OMe N4747 Q.sub.42 COOMe H Me OMe CH4748 Q.sub.42 COOMe H OMe OMe CH4749 Q.sub.42 COOMe H Me OMe N4750 Me Q.sub.42 H Me OMe CH4751 Me Q.sub.42 H OMe OMe CH4752 Me Q.sub.42 H Me OMe N4753 Q.sub.43 H H Me OMe CH4754 Q.sub.43 H H OMe OMe CH4755 Q.sub.43 H H Me OMe N4756 Q.sub.43 Cl H Me OMe CH4757 Q.sub.43 Cl H OMe OMe CH4758 Q.sub.43 Cl H Me OMe N4759 Q.sub.43 COOMe H Me OMe CH4760 Q.sub.43 COOMe H OMe OMe CH4761 Q.sub.43 COOMe H Me OMe N4762 Me Q.sub.43 H Me OMe CH4763 Me Q.sub.43 H OMe OMe CH4764 Me Q.sub.43 H Me OMe N4765 Q.sub.44 Cl H Me OMe CH4766 Q.sub.44 Cl H OMe OMe CH4767 Q.sub.44 Cl H Me OMe N4768 Q.sub.44 COOMe H Me OMe CH4769 Q.sub.44 COOMe H OMe OMe CH4770 Q.sub.44 COOMe H Me OMe N4771 Me Q.sub.44 H Me OMe CH4772 Me Q.sub.44 H OMe OMe CH4773 Me Q.sub.44 H Me OMe N4774 Q.sub.45 H H Me OMe CH4775 Q.sub.45 H H OMe OMe CH4776 Q.sub.45 H H Me OMe N4777 Q.sub.45 Me H Me OMe CH4778 Q.sub.45 Me H OMe OMe CH4779 Q.sub.45 Me H Me OMe N4780 Q.sub.45 Cl H Me OMe CH4781 Q.sub.45 Cl H OMe OMe CH4782 Q.sub.45 Cl H Me OMe N4783 Q.sub.45 Br H Me OMe CH4784 Q.sub.45 Br H OMe OMe CH4785 Q.sub.45 Br H Me OMe N4786 Q.sub.45 COOMe H Me OMe CH4787 Q.sub.45 COOMe H OMe OMe CH4788 Q.sub.45 COOMe H Me OMe N4789 Q.sub.45 COOEt H Me OMe CH4790 Q.sub.45 COOEt H OMe OMe CH4791 Q.sub.45 COOEt H Me OMe N4792 Me Q.sub.45 H Me Me CH4793 Me Q.sub.45 H Me OMe CH4794 Me Q.sub.45 H OMe OMe CH4795 Me Q.sub.45 H Me OMe N4796 Me Q.sub.45 H OMe OMe N4797 COOMe Q.sub.45 H Me OMe CH4798 COOMe Q.sub.45 H OMe OMe CH4799 COOMe Q.sub.45 H Me OMe N4800 Q.sub.46 H H Me OMe CH4801 Q.sub.46 H H OMe OMe CH4802 Q.sub.46 H H Me OMe N4803 Q.sub.46 Cl H Me OMe CH4804 Q.sub.46 Cl H OMe OMe CH4805 Q.sub.46 Cl H Me OMe N4806 Q.sub.46 COOMe H Me OMe CH4807 Q.sub.46 COOMe H OMe OMe CH4808 Q.sub.46 COOMe H Me OMe N4809 Me Q.sub.46 H Me OMe CH4810 Me Q.sub.46 H Me OMe CH4811 Me Q.sub.46 H Me OMe N4812 Q.sub.47 H H Me OMe CH4813 Q.sub.47 H H OMe OMe CH4814 Q.sub.47 H H Me OMe N4815 Q.sub.47 Cl H Me OMe CH4816 Q.sub.47 Cl H OMe OMe CH4817 Q.sub.47 Cl H Me OMe N4818 Q.sub.47 COOMe H Me OMe CH4819 Q.sub.47 COOMe H OMe OMe CH4820 Q.sub.47 COOMe H Me OMe N4821 Me Q.sub.47 H Me OMe CH4822 Me Q.sub.47 H OMe OMe CH4823 Me Q.sub.47 H Me OMe N4824 Q.sub.48 H Me OMe CH4825 Q.sub.48 H OMe OMe CH4826 Q.sub.48 H Me OMe N4827 Q.sub.48 Cl Me OMe CH4828 Q.sub.48 Cl OMe OMe CH4829 Q.sub.48 H Me OMe N4830 Q.sub.48 COOMe Me OMe CH4831 Q.sub.48 COOMe OMe OMe CH4832 Q.sub.48 COOMe Me OMe N4833 Me Q.sub.48 H Me OMe CH4834 Me Q.sub.48 H OMe OMe CH4835 Me Q.sub.48 H Me OMe N4836 Q.sub.49 H H Me OMe CH4837 Q.sub.49 H H OMe OMe CH4838 Q.sub.49 H H Me OMe N4839 Q.sub.49 Cl H Me OMe CH4840 Q.sub.49 Cl H OMe OMe CH4841 Q.sub.49 Cl H Me OMe N4842 Q.sub.49 COOMe H Me OMe CH4843 Q.sub.49 COOMe H OMe OMe CH4844 Q.sub.49 COOMe H Me OMe N4845 Me Q.sub.49 H Me OMe CH4846 Me Q.sub.49 H OMe OMe CH4847 Me Q.sub.49 H Me OMe N4848 Q.sub.50 H H Me OMe CH4849 Q.sub.50 H H OMe OMe CH4850 Q.sub.50 H H Me OMe N4851 Q.sub.50 Cl H Me OMe CH4852 Q.sub.50 Cl H OMe OMe CH4853 Q.sub.50 Cl H Me OMe N4854 Q.sub.50 COOMe H Me OMe CH4855 Q.sub.50 COOMe H OMe OMe CH4856 Q.sub.50 COOMe H Me OMe N4857 Me Q.sub.50 H Me OMe CH4858 Me Q.sub.50 H OMe OMe CH4859 Me Q.sub.50 H Me OMe N4860 Q.sub.51 H H Me OMe CH4861 Q.sub.51 H H OMe OMe CH4862 Q.sub.51 H H Me OMe N4863 Q.sub.51 Cl H Me OMe CH4864 Q.sub.51 Cl H OMe OMe CH4865 Q.sub.51 Cl H Me OMe N4866 Q.sub.51 COOMe H Me OMe CH4867 Q.sub.51 COOMe H OMe OMe CH4868 Q.sub.51 COOMe H Me OMe N4869 Me Q.sub.51 H Me OMe CH4870 Me Q.sub.51 H OMe OMe CH4871 Me Q.sub.51 H Me OMe N4872 Q.sub.52 Cl H Me OMe CH4873 Q.sub.52 Cl H OMe OMe CH4874 Q.sub.52 Cl H Me OMe N4875 Q.sub.52 COOMe H Me OMe CH4876 Q.sub.52 COOMe H OMe OMe CH4877 Q.sub.52 COOMe H Me OMe N4878 Me Q.sub.52 H Me OMe CH4879 Me Q.sub.52 H OMe OMe CH4880 Me Q.sub.52 H Me OMe N4881 Q.sub.53 Cl H Me OMe CH4882 Q.sub.53 Cl H OMe OMe CH4883 Q.sub.53 Cl H Me OMe N4884 Q.sub.53 COOMe H Me OMe CH4885 Q.sub.53 COOMe H OMe OMe CH4886 Q.sub.53 COOMe H Me OMe N4887 Me Q.sub.53 H Me OMe CH4888 Me Q.sub.53 H OMe OMe CH4889 Me Q.sub.53 H Me OMe N4890 Q.sub.54 H H Me OMe CH4891 Q.sub.54 H H OMe OMe CH4892 Q.sub.54 H H Me OMe N4893 Q.sub.54 Cl H Me OMe CH4894 Q.sub.54 Cl H OMe OMe CH4895 Q.sub.54 Cl H Me OMe N4896 Q.sub.54 COOMe H Me OMe CH4897 Q.sub.54 COOMe H OMe OMe CH4898 Q.sub.54 COOMe H Me OMe N4899 Me Q.sub.54 H Me OMe CH4900 Me Q.sub.54 H OMe OMe CH4901 Me Q.sub.54 H Me OMe N4902 Q.sub.55 H H Me OMe CH4903 Q.sub.55 H H OMe OMe CH4904 Q.sub.55 H H Me OMe N4905 Q.sub.55 Cl H Me OMe CH4906 Q.sub.55 Cl H OMe OMe CH4907 Q.sub.55 Cl H Me OMe N4908 Q.sub.55 COOMe H Me OMe CH4909 Q.sub.55 COOMe H OMe OMe CH4910 Q.sub.55 COOMe H Me OMe N4911 Me Q.sub.55 H Me OMe CH4912 Me Q.sub.55 H OMe OMe CH4913 Me Q.sub.55 H Me OMe N4914 Q.sub.56 H H Me OMe CH4915 Q.sub.56 H H OMe OMe CH4916 Q.sub.56 H H Me OMe N4917 Q.sub.56 Cl H Me OMe CH4918 Q.sub.56 Cl H OMe OMe CH4919 Q.sub.56 Cl H Me OMe N4920 Q.sub.56 COOMe H Me OMe CH4921 Q.sub.56 COOMe H OMe OMe CH4922 Q.sub.56 COOMe H Me OMe N4923 Me Q.sub.56 H Me OMe CH4924 Me Q.sub.56 H OMe OMe CH4925 Me Q.sub.56 H Me OMe N4926 Q.sub.57 Cl H Me OMe CH4927 Q.sub.57 Cl H OMe OMe CH4928 Q.sub.57 Cl H Me OMe N4929 Q.sub.57 COOMe H Me OMe CH4930 Q.sub.57 COOMe H OMe OMe CH4931 Q.sub.57 COOMe H Me OMe N4932 Me Q.sub.57 H Me OMe CH4933 Me Q.sub.57 H OMe OMe CH4934 Me Q.sub.57 H Me OMe N4935 Q.sub.58 Cl H Me OMe CH4936 Q.sub.58 Cl H OMe OMe CH4937 Q.sub.58 Cl H Me OMe N4938 Q.sub.58 COOMe H Me OMe CH4939 Q.sub.58 COOMe H OMe OMe CH4940 Q.sub.58 COOMe H Me OMe N4941 Me Q.sub.58 H Me OMe CH4942 Me Q.sub.58 H OMe OMe CH4943 Me Q.sub.58 H Me OMe N4944 Q.sub.59 H H Me OMe CH4945 Q.sub.59 H H OMe OMe CH4946 Q.sub.59 H H Me OMe N4947 Q.sub.59 Me H Me OMe CH4948 Q.sub.59 Me H OMe OMe CH4949 Q.sub.59 Me H Me OMe N4950 Q.sub.59 Cl H Me OMe CH4951 Q.sub.59 Cl H OMe OMe CH4952 Q.sub.59 Cl H Me OMe N4953 Q.sub.59 Br H Me OMe CH4954 Q.sub.59 Br H OMe OMe CH4955 Q.sub.59 Br H Me OMe N4956 Q.sub.59 COOMe H Me OMe CH4957 Q.sub.59 COOMe H Me OMe N4958 Q.sub.59 COOMe H Me OMe N4959 Q.sub.59 COOEt H Me OMe CH4960 Q.sub.59 COOEt H OMe OMe CH4961 Q.sub.59 COOEt H Me OMe N4962 Me Q.sub.59 H Me Me CH4963 Me Q.sub.59 H Me OMe CH4964 Me Q.sub.59 H OMe OMe CH4965 Me Q.sub.59 H Me OMe N4966 Me Q.sub.59 H Me OMe N4967 COMe Q.sub.59 H Me OMe CH4968 COMe Q.sub.59 H OMe OMe CH4969 COMe Q.sub.59 H Me OMe N4970 Q.sub.60 H H Me OMe CH4971 Q.sub.60 H H OMe OMe CH4972 Q.sub.60 H H Me OMe N4973 Q.sub.60 Cl H Me OMe CH4974 Q.sub.60 Cl H OMe OMe CH4975 Q.sub.60 Cl H Me OMe N4976 Q.sub.60 COOMe H Me OMe CH4977 Q.sub.60 COOMe H OMe OMe CH4978 Q.sub.60 COOMe H Me OMe N4979 Me Q.sub.60 H Me OMe CH4980 Me Q.sub.60 H OMe OMe CH4981 Me Q.sub.60 H Me OMe N4970 Q.sub.61 H H Me OMe CH4971 Q.sub.61 H H OMe OMe CH4972 Q.sub.61 H H Me OMe N4973 Q.sub.61 Cl H Me OMe CH4974 Q.sub.61 Cl H OMe OMe CH4975 Q.sub.61 Cl H Me OMe N4976 Q.sub.61 COOMe H Me OMe CH4977 Q.sub.61 COOMe H OMe OMe CH4978 Q.sub.61 COOMe H Me OMe N4979 Me Q.sub.61 H Me OMe CH4980 Me Q.sub.61 H OMe OMe CH4981 Me Q.sub.61 H Me OMe N4982 Q.sub.62 H H Me OMe CH4983 Q.sub.62 H H OMe OMe CH4984 Q.sub.62 H H Me OMe N4985 Q.sub.62 Cl H Me OMe CH4986 Q.sub.62 Cl H OMe OMe CH4987 Q.sub.62 Cl H Me OMe N4988 Q.sub.62 COOMe H Me OMe CH4989 Q.sub.62 COOMe H OMe OMe CH4990 Q.sub.62 COOMe H Me OMe N4991 Me Q.sub.62 H Me OMe CH4992 Me Q.sub.62 H OMe OMe CH4993 Me Q.sub.62 H Me OMe N4994 Q.sub.63 Cl H Me OMe CH4995 Q.sub.63 Cl H OMe OMe CH4996 Q.sub.63 Cl H Me OMe N4997 Q.sub.63 COOMe H Me OMe CH4998 Q.sub.63 COOMe H OMe OMe CH4999 Q.sub.63 COOMe H Me OMe N5000 Me Q.sub.63 H Me OMe CH5001 Me Q.sub.63 H OMe OMe CH5002 Me Q.sub.63 H Me OMe N5003 Q.sub.64 Cl H Me OMe CH5004 Q.sub.64 Cl H OMe OMe CH5005 Q.sub.64 Cl H Me OMe N5006 Q.sub.64 COOMe H Me OMe CH5007 Q.sub.64 COOMe H OMe OMe CH5008 Q.sub.64 COOMe H Me OMe N5009 Me Q.sub.64 H Me OMe CH5010 Me Q.sub.64 H OMe OMe CH5011 Me Q.sub.64 H Me OMe N5012 Q.sub.65 H H Me OMe CH5013 Q.sub.65 H H OMe OMe CH5014 Q.sub.65 H H Me OMe N5015 Q.sub.65 Cl H Me OMe CH5016 Q.sub.65 Cl H OMe OMe CH5017 Q.sub.65 Cl H Me OMe N5018 Q.sub.65 COOMe H Me OMe CH5019 Q.sub.65 COOMe H OMe OMe CH5020 Q.sub.65 COOMe H Me OMe N5021 Me Q.sub.65 H Me OMe CH5022 Me Q.sub.65 H OMe OMe CH5023 Me Q.sub.65 H Me OMe N5024 Q.sub.66 Cl H Me OMe CH5025 Q.sub.66 Cl H OMe OMe CH5026 Q.sub.66 Cl H Me OMe N5027 Q.sub.66 COOMe H Me OMe CH5028 Q.sub.66 COOMe H OMe OMe CH5029 Q.sub.66 COOMe H Me OMe N5030 Me Q.sub.66 H Me OMe CH5031 Me Q.sub.66 H OMe OMe CH5032 Me Q.sub.66 H Me OMe N5033 Q.sub.67 Cl H Me OMe CH5034 Q.sub.67 Cl H OMe OMe CH5035 Q.sub.67 Cl H Me OMe N5036 Q.sub.67 COOMe H Me OMe CH5037 Q.sub.67 COOMe H OMe OMe CH5038 Q.sub.67 COOMe H Me OMe N5039 Me Q.sub.67 H Me OMe CH5040 Me Q.sub.67 H OMe OMe CH5041 Me Q.sub.67 H Me OMe N5042 Q.sub.68 Cl H Me OMe CH5043 Q.sub.68 Cl H OMe OMe CH5044 Q.sub.68 Cl H Me OMe N5045 Q.sub.68 COOMe H Me OMe CH5046 Q.sub.68 COOMe H OMe OMe CH5047 Q.sub.68 COOMe H Me OMe N5048 Me Q.sub.68 H Me OMe CH5049 Me Q.sub.68 H OMe OMe CH5050 Me Q.sub.68 H Me OMe N5051 Q.sub.69 Cl H Me OMe CH5052 Q.sub.69 Cl h OEM OMe CH5053 Q.sub.69 CL H Me OMe N5054 Q.sub.69 COOMe H OMe OMe CH5055 Q.sub.69 COOMe H OMe OMe CH5056 Q.sub.69 COOMe H Me OMe N5057 Me Q.sub.69 H Me OMe CH5058 Me Q.sub.69 H OMe OMe CH5059 Me Q.sub.69 H Me OMe N5060 Q.sub.70 H H Me OMe CH5061 Q.sub.70 H H OMe OMe CH5062 Q.sub.70 H H Me OMe N5063 Q.sub.70 Cl H Me OMe CH5064 Q.sub.70 Cl H OMe OMe CH5065 Q.sub.70 Cl H Me OMe N5066 Q.sub.70 COOMe H Me OMe CH5067 Q.sub.70 COOMe H OMe OMe CH5068 Q.sub.70 COOMe H Me OMe N5069 Me Q.sub.70 H Me OMe CH5070 Me Q.sub.70 H OMe OMe CH5071 Me Q.sub.70 H Me OMe N5072 Q.sub.71 Cl H Me OMe CH5073 Q.sub.71 Cl H OMe OMe CH5074 Q.sub.71 Cl H Me OMe N5075 Q.sub.71 COOMe H Me OMe CH5076 Q.sub.71 COOMe H OMe OMe CH5077 Q.sub.71 COOMe H Me OMe N5078 Me Q.sub.71 H Me OMe CH5079 Me Q.sub.71 H OMe OMe CH5080 Me Q.sub.71 H Me OMe N5081 Q.sub.72 Cl H Me OMe CH5082 Q.sub.72 Cl H OMe OMe CH5083 Q.sub.72 Cl H Me OMe N5084 Q.sub.72 COOMe H Me OMe CH5085 Q.sub.72 COOMe H OMe OMe CH5086 Q.sub.72 COOMe H Me OMe N5087 Me Q.sub.72 H Me OMe CH5088 Me Q.sub.72 H OMe OMe CH5089 Me Q.sub.72 H Me OMe N5090 Q.sub.73 Cl H Me OMe CH5091 Q.sub.73 Cl H OMe OMe CH5092 Q.sub.73 Cl H Me OMe N5093 Q.sub.73 COOMe H Me OMe CH5094 Q.sub.73 COOMe H OMe OMe CH5095 Q.sub.73 COOMe H Me OMe N5096 Me Q.sub.73 H Me OMe CH5097 Me Q.sub.73 H OMe OMe CH5098 Me Q.sub.73 H Me OMe N5099 Q.sub.74 Cl H Me OMe CH5100 Q.sub.74 Cl H OMe OMe CH5101 Q.sub.74 Cl H Me OMe N5102 Q.sub.74 COOMe H Me OMe CH5103 Q.sub.74 COOMe H OMe OMe CH5104 Q.sub.74 COOMe H Me OMe N5105 Me Q.sub.74 H Me OMe CH5106 Me Q.sub.74 H OMe OMe CH5107 Me Q.sub.74 H Me OMe N5108 Q.sub.75 Cl H Me OMe CH5109 Q.sub.75 Cl H OMe OMe CH5110 Q.sub.75 Cl H Me OMe N5111 Q.sub.75 CL H Me OMe N5112 Q.sub.75 COOMe H OMe OMe CH5113 Q.sub.75 COOMe H Me OMe N5114 Me Q.sub.75 H Me OMe CH5115 Me Q.sub.75 H OMe OMe CH5116 Me Q.sub.75 H Me OMe N5117 76 Cl H Me OMe CH5118 Q.sub.76 Cl H OMe OMe CH5119 Q.sub.76 Cl H Me OMe N5120 Q.sub.76 COOMe H Me OMe CH5121 Q.sub.76 COOMe H OMe OMe CH5122 Q.sub.76 COOMe H Me OMe N5123 Me Q.sub.76 H Me OMe CH5124 Me Q.sub.76 H OMe OMe CH5125 Me Q.sub.76 H Me OMe N5720 Q.sub.77 Cl H Me OMe CH5721 Q.sub.77 Cl H OMe OMe CH5722 Q.sub.77 Cl H Me OMe N5723 Q.sub.77 COOMe H Me OMe CH5724 Q.sub.77 COOMe H OMe OMe CH5725 Q.sub.77 COOMe H Me OMe N5726 Me Q.sub.77 H Me OMe CH5727 Me Q.sub.77 H OMe OMe CH5728 Me Q.sub.77 H Me OMe N5729 Q.sub.78 H H Me OMe CH5730 Q.sub.78 H H OMe OMe CH5731 Q.sub.78 H H Me OMe N5732 Q.sub.78 Me H Me OMe CH5733 Q.sub.78 Me H OMe OMe CH5734 Q.sub.78 Me H Me OMe N5735 Q.sub.78 Cl H Me OMe CH5736 Q.sub.78 Cl H OMe OMe CH5737 Q.sub.78 Cl H Me OMe N5738 Q.sub.78 Br H Me OMe CH5739 Q.sub.78 Br H OMe OMe CH5740 Q.sub.78 Br H Me OMe N5741 Q.sub.78 COOMe H Me OMe CH5742 Q.sub.78 COOMe H OMe OMe CH5743 Q.sub.78 COOMe H Me OMe N5744 Q.sub.78 COOEt H Me OMe CH5745 Q.sub.78 COOEt H OMe OMe CH5746 Q.sub.78 COOEt H Me OMe N5747 Me Q.sub.78 H Me Me CH5748 Me Q.sub.78 H Me OMe CH5749 Me Q.sub.78 H OMe OMe CH5750 Me Q.sub.78 H Me OMe N5751 Me Q.sub.78 H OMe OMe N5752 COOMe Q.sub.78 H Me OMe CH5753 COOMe Q.sub.78 H OMe OMe CH5754 COOMe Q.sub.78 H Me OMe N5755 Q.sub.79 H H Me OMe CH5756 Q.sub.79 H H OMe OMe CH5757 Q.sub.79 H H Me OMe N5758 Q.sub.79 Me H Me OMe CH5759 Q.sub.79 Me H OMe OMe CH5760 Q.sub.79 Me H Me OMe N5761 Q.sub.79 Cl H Me OMe CH5762 Q.sub.79 Cl H OMe OMe CH5763 Q.sub.79 Cl H Me OMe N5764 Q.sub.79 Br H Me OMe CH5765 Q.sub.79 Br H OMe OMe CH5766 Q.sub.79 Br H Me OMe N5767 Q.sub.79 COOMe H Me OMe CH5768 Q.sub.79 COOMe H OMe OMe CH5769 Q.sub.79 COOMe H Me OMe N5770 Q.sub.79 COOEt H Me OMe CH5771 Q.sub.79 COOEt H OMe OMe CH5772 Q.sub.79 COOEt H Me OMe N5773 Me Q.sub.79 H Me Me CH5774 Me Q.sub.79 H Me OMe CH5775 Me Q.sub.79 H OMe OMe CH5776 Me Q.sub.79 H Me OMe N5777 Me Q.sub.79 H OMe OMe N5778 COOMe Q.sub.79 H Me OMe CH5779 COOMe Q.sub.79 H OMe OMe CH5780 COOMe Q.sub.79 H Me OMe N5781 Q.sub.80 H H Me OMe CH5782 Q.sub.80 H H OMe OMe CH5783 Q.sub.80 H H Me OMe N5784 Q.sub.80 Cl H Me OMe CH5785 Q.sub.80 Cl H OMe OMe CH5786 Q.sub.80 Cl H Me OMe N5787 Q.sub.80 COOMe H Me OMe CH5788 Q.sub.80 COOMe H OMe OMe CH5789 Q.sub.80 COOMe H Me OMe N5790 Me Q.sub.80 H Me OMe CH5791 Me Q.sub.80 H OMe OMe CH5792 Me Q.sub.80 H Me OMe N5793 Q.sub.81 Cl H Me OMe CH5794 Q.sub.81 Cl H OMe OMe CH5795 Q.sub.81 Cl H Me OMe N5796 Q.sub.81 COOMe H Me OMe CH5797 Q.sub.81 COOMe H OMe OMe CH5798 Q.sub.81 COOMe H Me OMe N5799 Me Q.sub.81 H Me OMe CH5800 Me Q.sub.81 H OMe OMe CH5801 Me Q.sub.81 H Me OMe N5802 Q.sub.82 Cl H Me OMe CH5803 Q.sub.82 Cl H OMe OMe CH5804 Q.sub.82 Cl H Me OMe N5805 Q.sub.82 COOMe H OMe OMe CH5806 Q.sub.82 COOMe H OMe OMe CH5807 Q.sub.82 COOMe H Me OMe N5808 Me Q.sub.82 H Me OMe CH5809 Me Q.sub.82 H OMe OMe CH5810 Me Q.sub.82 H Me OMe N5811 Q.sub.83 Cl H Me OMe CH5812 Q.sub.83 Cl H OMe OMe CH5813 Q.sub.83 Cl H Me OMe N5814 Q.sub.83 COOMe H Me OMe CH5815 Q.sub.83 COOMe H OMe OMe CH5816 Q.sub.83 COOMe H Me OMe N5817 Me Q.sub.83 H Me OMe CH5818 Me Q.sub.83 H OMe OMe CH5819 Me Q.sub.83 H Me OMe N6551 Q.sub.16 COOEt H OMe OMe CH__________________________________________________________________________
In the above, Q.sub.1 to Q.sub.83 are as defined above.
TABLE 4__________________________________________________________________________ ##STR30##No. A B D E W X Y Z__________________________________________________________________________5126 Q.sub.1 H COOMe H S Me OMe CH5127 Q.sub.1 H COOMe H S OMe OMe CH5128 Q.sub.1 H COOEt H S Me OMe CH5129 Q.sub.1 H COOEt H S OMe OMe CH5130 Q.sub.1 H COOEt H S Me OMe N5131 Q.sub.1 H COOMe Me O Me OMe CH5132 Q.sub.1 H COOMe Me O OMe OMe CH5133 Q.sub.1 H COOEt Me O Me OMe CH5134 Q.sub.1 H COOEt Me O OMe OMe CH5135 Q.sub.1 H COOEt Me O Me OMe N5136 Q.sub.1 H COOMe OMe O Me OMe CH5137 Q.sub.1 H COOMe OMe O OMe OMe CH5138 Q.sub.1 H COOEt OMe O Me OMe CH5139 Q.sub.1 H COOEt OMe O OMe OMe CH5140 Q.sub.1 H COOEt OMe O Me OMe N5141 Q.sub.1 H COOMe CH.sub.2 CHCH.sub.2 O Me OMe CH5142 Q.sub.1 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH5143 Q.sub.1 H COOEt CH.sub.2 CHCH.sub.2 O Me OMe CH5144 Q.sub.1 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH5145 Q.sub.1 H COOEt CH.sub.2 CHCH.sub.2 O Me OMe N5146 Q.sub.1 H COOMe CH.sub.2 CCH O Me OMe CH5147 Q.sub.1 H COOMe CH.sub.2 CCH O OMe OMe CH5148 Q.sub.1 H COOEt CH.sub.2 CCH O Me OMe CH5149 Q.sub.1 H COOEt CH.sub.2 CCH O OMe OMe CH5150 Q.sub.1 H COOEt CH.sub.2 CCH O Me OMe N5151 Q.sub.2 H COOMe H S Me OMe CH5152 Q.sub.2 H COOMe H S OMe OMe CH5153 Q.sub.2 H COOEt H S Me OMe CH5154 Q.sub.2 H COOEt H S OMe OMe CH5155 Q.sub.2 H COOMe Me O Me OMe CH5156 Q.sub.2 H COOMe Me O OMe OMe CH5157 Q.sub.2 H COOEt Me O OMe OMe CH5158 Q.sub.2 H COOMe OMe O Me OMe CH5159 Q.sub.2 H COOMe OMe O OMe OMe CH5160 Q.sub.2 H COOEt OMe O OMe OMe CH5161 Q.sub.2 H COOMe CH.sub.2 CHCH.sub.2 O Me OMe CH5162 Q.sub.2 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH5163 Q.sub.2 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH5164 Q.sub.2 H COOMe CH.sub.2 CCH O Me OMe CH5165 Q.sub.2 H COOMe CH.sub.2 CCH O OMe OMe CH5166 Q.sub.2 H COOEt CH.sub.2 CCH O OMe OMe CH5167 Q.sub.8 H COOMe H S Me OMe CH5168 Q.sub.8 H COOMe H S OMe OMe CH5169 Q.sub.8 H COOEt H S Me OMe CH5170 Q.sub.8 H COOEt H S OMe OMe CH5171 Q.sub.8 H COOMe Me O Me OMe CH5172 Q.sub.8 H COOMe Me O OMe OMe CH5173 Q.sub.8 H COOEt Me O OMe OMe CH5174 Q.sub.8 H COOMe OMe O Me OMe CH5175 Q.sub.8 H COOMe OMe O OMe OMe CH5176 Q.sub.8 H COOEt OMe O OMe OMe CH5177 Q.sub.8 H COOMe CH.sub.2 CHCH.sub.2 O Me OMe CH5178 Q.sub.8 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH5179 Q.sub.8 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH5180 Q.sub.8 H COOMe CH.sub.2 C CH O Me OMe CH5181 Q.sub.8 H COOMe CH.sub.2 CCH O OMe OMe CH5182 Q.sub.8 H COOEt CH.sub.2 CCH O OMe OMe CH5183 Q.sub.32 H COOMe H S Me OMe CH5184 Q.sub.32 H COOMe H S OMe OMe CH5185 Q.sub.32 H COOEt H S Me OMe CH5186 Q.sub.32 H COOEt H S OMe OMe CH5187 Q.sub.32 H COOMe Me O Me OMe CH5188 Q.sub.32 H COOMe Me O OMe OMe CH5189 Q.sub.32 H COOEt Me O OMe OMe CH5190 Q.sub.32 H COOMe OMe O Me OMe CH5191 Q.sub.32 H COOMe OMe O OMe OMe CH5192 Q.sub.32 H COOEt OMe O OMe OMe CH5193 Q.sub.32 H COOMe CH.sub.2 CHCH.sub.2 O Me OMe CH5194 Q.sub.32 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH5195 Q.sub.32 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH5196 Q.sub.32 H COOMe CH.sub. 2 CCH O Me OMe CH5197 Q.sub.32 H COOMe CH.sub.2 CCH O OMe OMe CH5198 Q.sub.32 H COOEt CH.sub.2 CCH O OMe OMe CH5199 Q.sub.45 H COOMe H S Me OMe CH5200 Q.sub.45 H COOMe H S OMe OMe CH5201 Q.sub.45 H COOEt H S Me OMe CH5202 Q.sub.45 H COOEt H S OMe OMe CH5203 Q.sub.45 H COOMe Me O Me OMe CH5204 Q.sub.45 H COOMe Me O OMe OMe CH5205 Q.sub.45 H COOEt Me O OMe OMe CH5206 Q.sub.45 H COOMe OMe O Me OMe CH5207 Q.sub.45 H COOMe OMe O OMe OMe CH5208 Q.sub.45 H COOEt OMe O OMe OMe CH5209 Q.sub.45 H COOMe CH.sub.2 CHCH.sub.2 O Me OMe CH5210 Q.sub.45 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH5211 Q.sub.45 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH5212 Q.sub.45 H COOMe CH.sub.2 CCH O Me OMe CH5213 Q.sub.45 H COOMe CH.sub.2 CCH O OMe OMe CH5214 Q.sub.45 H COOEt CH.sub.2 CCH O OMe OMe CH5215 Q.sub.59 H COOMe H S Me OMe CH5216 Q.sub.59 H COOMe H S OMe OMe CH5217 Q.sub.59 H COOEt H S Me OMe CH5218 Q.sub.59 H COOEt H S OMe OMe CH5219 Q.sub.59 H COOMe Me O Me OMe CH5220 Q.sub.59 H COOMe Me O OMe OMe CH5221 Q.sub.59 H COOEt Me O OMe OMe CH5222 Q.sub.59 H COOMe OMe O Me OMe CH5223 Q.sub.59 H COOMe OMe O OMe OMe CH5224 Q.sub.59 H COOEt OMe O OMe OMe CH5225 Q.sub.59 H COOMe CH.sub.2 CHCH.sub.2 O Me OMe CH5226 Q.sub.59 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH5227 Q.sub.59 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH5228 Q.sub.59 H COOMe CH.sub.2 CCH O Me OMe CH5229 Q.sub.59 H COOMe CH.sub.2 CCH O OMe OMe CH5230 Q.sub.59 H COOEt CH.sub.2 CCH O OMe OMe CH5231 Me H Q.sub.1 H S Me OMe CH5232 Me H Q.sub.1 H S OMe OMe CH5233 Me H Q.sub.1 H S Me OMe CH5234 Me H Q.sub.1 H S OMe OMe CH5235 Me H Q.sub.1 H S Me OMe N5236 Me H Q.sub.1 Me O Me OMe CH5237 Me H Q.sub.1 Me O OMe OMe CH5238 Me H Q.sub.1 Me O Me OMe CH5239 Me H Q.sub.1 Me O OMe OMe CH5240 Me H Q.sub.1 Me O Me OMe N5241 Me H Q.sub.1 OMe O Me OMe CH5242 Me H Q.sub.1 OMe O OMe OMe CH5243 Me H Q.sub. 1 OMe O Me OMe CH5244 Me H Q.sub.1 OMe O OMe OMe CH5245 Me H Q.sub.1 OMe O Me OMe N5246 Me H Q.sub.1 CH.sub.2 CHCH.sub.2 O Me OMe CH5247 Me H Q.sub.1 CH.sub.2 CHCH.sub.2 O OMe OMe CH5248 Me H Q.sub.1 CH.sub.2 CHCH.sub.2 O Me OMe CH5249 Me H Q.sub.1 CH.sub.2 CHCH.sub.2 O OMe OMe CH5250 Me H Q.sub.1 CH.sub.2 CHCH.sub.2 O Me OMe N5251 Me H Q.sub.1 CH.sub.2 CCH O Me OMe CH5252 Me H Q.sub.1 CH.sub.2 CCH O OMe OMe CH5253 Me H Q.sub.1 CH.sub.2 CCH O Me OMe CH5254 Me H Q.sub.1 CH.sub.2 CCH O OMe OMe CH5255 Me H Q.sub.1 CH.sub.2 C CH O Me OMe N5820 Q.sub.5 H COOMe H S Me OMe CH5821 Q.sub.5 H COOMe H S OMe OMe CH5822 Q.sub.5 H COOEt H S Me OMe CH5823 Q.sub.5 H COOEt H S OMe OMe CH5824 Q.sub.5 H COOMe Me O Me OMe CH5825 Q.sub.5 H COOMe Me O OMe OMe CH5826 Q.sub.5 H COOEt Me O OMe OMe CH5827 Q.sub.5 H COOMe OMe O Me OMe CH5828 Q.sub.5 H COOMe OMe O OMe OMe CH5829 Q.sub.5 H COOEt OMe O OMe OMe CH5830 Q.sub.5 H COOMe CH.sub.2 CHCH.sub.2 O Me OMe CH5831 Q.sub.5 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH5832 Q.sub.5 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH5833 Q.sub.5 H COOMe CH.sub.2 CCH O Me OMe CH5834 Q.sub.5 H COOMe CH.sub.2 CCH O OMe OMe CH5835 Q.sub.5 H COOEt CH.sub.2 C CH O OMe OMe CH5836 Q.sub.10 H COOMe H S Me OMe CH5837 Q.sub.10 H COOMe H S OMe OMe CH5838 Q.sub.10 H COOEt H S Me OMe CH5839 Q.sub.10 H COOEt H S OMe OMe CH5840 Q.sub.10 H COOMe Me O Me OMe CH5841 Q.sub.10 H COOMe Me O OMe OMe CH5842 Q.sub.10 H COOEt Me O OMe OMe CH5843 Q.sub.10 H COOMe OMe O Me OMe CH5844 Q.sub.10 H COOMe OMe O OMe OMe CH5845 Q.sub.10 H COOEt OMe O OMe OMe CH5846 Q.sub.10 H COOMe CH.sub.2 CHCH.sub.2 O Me OMe CH5847 Q.sub.10 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH5848 Q.sub.10 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH5849 Q.sub.10 H COOMe CH.sub.2 CCH O Me OMe CH5850 Q.sub.10 H COOMe CH.sub.2 CCH O OMe OMe CH5851 Q.sub.10 H COOEt CH.sub.2 CCH O OMe OMe CH5852 Q.sub.78 H COOMe H S Me OMe CH5853 Q.sub.78 H COOMe H S OMe OMe CH5854 Q.sub.78 H COOEt H S Me OMe CH5855 Q.sub.78 H COOEt H S OMe OMe CH5856 Q.sub.78 H COOMe Me O Me OMe CH5857 Q.sub.78 H COOMe Me O OMe OMe CH5858 Q.sub.78 H COOEt Me O OMe OMe CH5859 Q.sub.78 H COOMe OMe O Me OMe CH5860 Q.sub.78 H COOMe OMe O OMe OMe CH5861 Q.sub.78 H COOEt OMe O OMe OMe CH5862 Q.sub.78 H COOMe CH.sub.2 CHCH.sub.2 O Me OMe CH5863 Q.sub.78 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH5864 Q.sub.78 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH5865 Q.sub.78 H COOMe CH.sub.2 CCH O Me OMe CH5866 Q.sub.78 H COOMe CH.sub.2 C CH O OMe OMe CH5867 Q.sub.78 H COOEt CH.sub.2 CCH O OMe OMe CH5868 Q.sub.79 H COOMe H S Me OMe CH5869 Q.sub.79 H COOMe H S OMe OMe CH5870 Q.sub.79 H COOEt H S Me OMe CH5871 Q.sub.79 H COOEt H S OMe OMe CH5872 Q.sub.79 H COOMe Me O Me OMe CH5873 Q.sub.79 H COOMe Me O OMe OMe CH5874 Q.sub.79 H COOEt Me O OMe OMe CH5875 Q.sub.79 H COOMe OMe O Me OMe CH5876 Q.sub.79 H COOMe OMe O OMe OMe CH5877 Q.sub.79 H COOEt OMe O OMe OMe CH5878 Q.sub.79 H COOMe CH.sub.2 CHCH.sub.2 O Me OMe CH5879 Q.sub.79 H COOMe CH.sub.2 CHCH.sub.2 O OMe OMe CH5880 Q.sub.79 H COOEt CH.sub.2 CHCH.sub.2 O OMe OMe CH5881 Q.sub.79 H COOMe CH.sub.2 CCH O Me OMe CH5882 Q.sub.79 H COOMe CH.sub. 2 CCH O OMe OMe CH5883 Q.sub.79 H COOEt CH.sub.2 CCH O OMe OMe CH__________________________________________________________________________
In the above, Q.sub.1 to Q.sub.79 are as defined above.
TABLE 5______________________________________ ##STR31##No. A B D X.sup.1 Y.sup.1 Z______________________________________5256 Q.sub.1 H COOMe Me Me CH5257 Q.sub.1 H COOMe Me OMe CH5258 Q.sub.1 H COOEt Me Me CH5259 Q.sub.1 H COOEt Me OMe CH5260 Q.sub.1 H COOEt Me Me N5261 Q.sub.2 H COOMe Me Me CH5262 Q.sub.2 H COOMe Me OMe CH5263 Q.sub.8 H COOMe Me Me CH5264 Q.sub.8 H COOMe Me OMe CH5265 Q.sub.32 H COOMe Me Me CH5266 Q.sub.32 H COOMe Me OMe CH5267 Q.sub.45 H COOMe Me Me CH5268 Q.sub.45 H COOMe Me OMe CH5269 Q.sub.59 H COOMe Me Me CH5270 Q.sub.59 H COOMe Me OMe CH5271 Me H Q.sub.1 Me Me CH5272 Me H Q.sub.1 Me OMe CH5273 Me H Q.sub.1 Me Me N5884 Q.sub.5 H COOMe Me Me CH5885 Q.sub.5 H COOMe Me OMe CH5886 Q.sub.10 H COOMe Me Me CH5887 Q.sub.10 H COOMe Me OMe CH5888 Q.sub.78 H COOMe Me Me CH5889 Q.sub.78 H COOMe Me OMe CH5890 Q.sub.79 H COOMe Me Me CH5891 Q.sub.79 H COOMe Me OMe CH______________________________________
In the above, Q.sub.1 to Q.sub.79 are as defined above.
TABLE 6______________________________________ ##STR32##No. A B D X.sup.1 Y.sup.1 Z______________________________________5274 Q.sub.1 Me Me Me Me CH5275 Q.sub.1 Me Me Me OMe CH5276 Q.sub.1 Me COOMe Me Me CH5277 Q.sub.1 Me COOMe Me OMe CH5278 Q.sub.1 Me COOMe Me Me N5279 Q.sub.2 Me COOMe Me Me CH5280 Q.sub.2 Me COOMe Me OMe CH5281 Q.sub.8 Me COOMe Me Me CH5282 Q.sub.8 Me COOMe Me OMe CH5283 Q.sub.32 Me COOMe Me Me CH5284 Q.sub.32 Me COOMe Me OMe CH5285 Q.sub.45 Me COOMe Me Me CH5286 Q.sub.45 Me COOMe Me OMe CH5287 Q.sub.59 Me COOMe Me Me CH5288 Q.sub.59 Me COOMe Me OMe CH______________________________________
In the above, Q.sub.1 to Q.sub.59 are as defined above.
TABLE 7______________________________________ ##STR33##No. A B D X.sup.1 Y.sup.1 Z______________________________________5289 Q.sub.1 Cl H Me Me CH5290 Q.sub.1 Cl H Me OMe CH5291 Q.sub.1 COOMe H Me Me CH5292 Q.sub.1 COOMe H Me OMe CH5293 Me Q.sub.1 H Me Me CH5294 Me Q.sub.1 H Me OMe CH5295 Q.sub.2 Cl H Me Me CH5296 Q.sub.2 Cl H Me OMe CH5297 Q.sub.8 Cl H Me Me CH5298 Q.sub.8 Cl H Me OMe CH5299 Q.sub.45 Cl H Me Me CH5300 Q.sub.45 Cl H Me OMe CH______________________________________
In the above, Q.sub.1 to Q.sub.45 are as defined above.
TABLE 8______________________________________ ##STR34##No. A B D X.sup.2 Y.sup.2______________________________________5301 Q.sub.1 H COOMe Me Me5302 Q.sub.1 H COOMe OMe Me5303 Q.sub.1 H COOMe SMe Me5304 Q.sub.1 H COOEt Me Me5305 Q.sub.1 H COOEt OMe Me5306 Q.sub.1 H COOEt SMe Me5307 Q.sub.2 H COOMe Me Me5308 Q.sub.2 H COOMe OMe Me5309 Q.sub.8 H COOMe Me Me5310 Q.sub.8 H COOMe OMe Me5311 Q.sub.32 H COOMe Me Me5312 Q.sub.32 H COOMe OMe Me5313 Q.sub.45 H COOMe Me Me5314 Q.sub.45 H COOMe OMe Me5315 Q.sub.59 H COOMe Me Me5316 Q.sub.59 H COOMe OMe Me5317 Me H Q.sub.1 Me Me5318 Me H Q.sub.1 OMe Me5319 Me H Q.sub.1 SMe Me5892 Q.sub.5 H COOMe Me Me5893 Q.sub.5 H COOMe OMe Me5894 Q.sub.10 H COOMe Me Me5895 Q.sub.10 H COOMe OMe Me5896 Q.sub.78 H COOMe Me Me5897 Q.sub.78 H COOMe OMe Me5898 Q.sub.79 H COOMe Me Me5899 Q.sub.79 H COOMe OMe Me______________________________________
In the above, Q.sub.1 to Q.sub.79 are as defined above.
TABLE 9______________________________________ ##STR35##No. A B D X.sup.2 Y.sup.2______________________________________5320 Q.sub.1 Me Me Me Me5321 Q.sub.1 Me Me OMe Me5322 Q.sub.1 Me COOMe Me Me5323 Q.sub.1 Me COOMe OMe Me5324 Q.sub.1 Me COOMe SMe Me5325 Q.sub.2 Me COOMe Me Me5326 Q.sub.2 Me COOMe OMe Me5327 Q.sub.8 Me COOMe Me Me5328 Q.sub.8 Me COOMe OMe Me5329 Q.sub.32 Me COOMe Me Me5330 Q.sub.32 Me COOMe OMe Me5331 Q.sub.45 Me COOMe Me Me5332 Q.sub.45 Me COOMe OMe Me5333 Q.sub.59 Me COOMe Me Me5334 Q.sub.59 Me COOMe OMe Me______________________________________
In the above, Q.sub.1 to Q.sub.59 are as defined above.
TABLE 10______________________________________ ##STR36##No. A B D X.sup.2 Y.sup.2______________________________________5335 Q.sub.1 Cl H Me Me5336 Q.sub.1 Cl H OMe Me5337 Q.sub.1 COOMe H Me Me5338 Q.sub.1 COOMe H OMe Me5339 Me Q.sub.1 H Me Me5340 Me Q.sub.1 H OMe Me5341 Q.sub.2 Cl H Me Me5342 Q.sub.2 Cl H OMe Me5343 Q.sub.8 Cl H Me Me5344 Q.sub.8 Cl H OMe Me5345 Q.sub.45 Cl H Me Me5346 Q.sub.45 Cl H OMe Me______________________________________
In the above, Q.sub.1 to Q.sub.45 are as defined above.
TABLE 11__________________________________________________________________________ ##STR37##No. A B D X Y Z__________________________________________________________________________5900 CH.sub.2 Q.sub.1 H COOMe Me Me CH5901 CH.sub.2 Q.sub.1 H COOMe Me OMe CH5902 CH.sub.2 Q.sub.1 H COOMe OMe OMe CH5903 CH.sub.2 Q.sub.1 H COOMe Me Me N5904 CH.sub.2 Q.sub.1 H COOMe Me OMe N5905 CH.sub.2 Q.sub.1 H COOMe OMe OMe N5906 CH.sub.2 Q.sub.1 H COOMe Me OCHF.sub.2 CH5907 CH.sub.2 Q.sub.1 H COOMe Cl OMe CH5908 CH.sub.2 Q.sub.1 H COOEt Me Me CH5909 CH.sub.2 Q.sub.1 H COOEt Me OMe CH5910 CH.sub.2 Q.sub.1 H COOEt OMe OMe CH5911 CH.sub. 2 Q.sub.1 H COOEt Me Me N5912 CH.sub.2 Q.sub.1 H COOEt Me OMe N5913 CH.sub.2 Q.sub.1 H COOEt OMe OMe N5914 CH.sub.2 Q.sub.1 H COOEt Me OCHF.sub.2 CH5915 CH.sub.2 Q.sub.1 H COOEt Cl OMe CH5916 CH.sub.2 Q.sub.1 H COOPrn Me OMe CH5917 CH.sub.2 Q.sub.1 H COOPrn OMe OMe CH5918 CH.sub.2 Q.sub.1 H COOPrn Me OMe N5919 CH.sub.2 Q.sub.1 H COOPri Me OMe CH5920 CH.sub.2 Q.sub.1 H COOPri OMe OMe CH5921 CH.sub.2 Q.sub.1 H COOPri Me OMe N5922 CH.sub.2 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl Me OMe CH5923 CH.sub.2 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl OMe OMe CH5924 CH.sub.2 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl Me OMe N5925 CH.sub.2 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 Me OMe CH5926 CH.sub.2 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 OMe OMe CH5927 CH.sub.2 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 Me OMe N5928 CH.sub.2 Q.sub.1 H COOCH.sub.2 CCH Me OMe CH5929 CH.sub.2 Q.sub.1 H COOCH.sub.2 CCH OMe OMe CH5930 CH.sub.2 Q.sub.1 H COOCH.sub.2 CCH Me OMe N5931 CH.sub.2 Q.sub.1 Me COOMe Me Me CH5932 CH.sub.2 Q.sub.1 Me COOMe Me OMe CH5933 CH.sub.2 Q.sub.1 Me COOMe OMe OMe CH5934 CH.sub.2 Q.sub.1 Me COOMe Me OMe N5935 CH.sub.2 Q.sub.1 Me COOMe OMe OMe N5936 CH.sub.2 Q.sub.1 Me COOEt Me Me CH5937 CH.sub.2 Q.sub.1 Me COOEt Me OMe CH5938 CH.sub.2 Q.sub.1 Me COOEt OMe OMe CH5939 CH.sub.2 Q.sub.1 Me COOEt Me OMe N5940 CH.sub.2 Q.sub.1 Me COOEt OMe OMe N5941 CH.sub.2 Q.sub.1 Cl COOMe Me OMe CH5942 CH.sub.2 Q.sub.1 Cl COOMe OMe OMe CH5943 CH.sub.2 Q.sub.1 Cl COOMe Me OMe N5944 CH.sub.2 Q.sub.1 Cl COOEt Me OMe CH5945 CH.sub.2 Q.sub.1 Cl COOEt OMe OMe CH5946 CH.sub.2 Q.sub.1 Cl COOEt Me OMe N5947 CH.sub.2 Q.sub.1 OMe COOMe Me OMe CH5948 CH.sub.2 Q.sub.1 OMe COOMe OMe OMe CH5949 CH.sub.2 Q.sub.1 OMe COOMe Me OMe N5950 CH.sub.2 Q.sub.1 OMe COOEt Me OMe CH5951 CH.sub.2 Q.sub.1 OMe COOEt OMe OMe CH5952 CH.sub.2 Q.sub.1 OMe COOEt Me OMe N5953 CH.sub.2 Q.sub.1 H Cl Me OMe CH5954 CH.sub.2 Q.sub.1 H Cl OMe OMe CH5955 CH.sub.2 Q.sub.1 H Cl Me OMe N5956 CH.sub.2 Q.sub.1 H NO.sub.2 Me OMe CH5957 CH.sub.2 Q.sub.1 H NO.sub.2 OMe OMe CH5958 CH.sub.2 Q.sub.1 H NO.sub.2 Me OMe N5959 CH.sub.2 Q.sub.1 H SO.sub.2 NMe.sub.2 Me OMe CH5960 CH.sub.2 Q.sub.1 H SO.sub.2 NMe.sub.2 OMe OMe CH5961 CH.sub.2 Q.sub.1 H SO.sub.2 NMe.sub.2 Me OMe N5962 CH.sub.2 Q.sub.1 H CN Me OMe CH5963 CH.sub.2 Q.sub.1 H CN OMe OMe CH5964 CH.sub.2 Q.sub.1 H CN Me OMe N5965 CH.sub.2 Q.sub.1 Me CN Me OMe CH5966 CH.sub.2 Q.sub.1 Me CN OMe OMe CH5967 CH.sub.2 Q.sub.1 Me CN Me OMe N5968 CH.sub.2 Q.sub.1 H Me Me OMe CH5969 CH.sub.2 Q.sub.1 H Me OMe OMe CH5970 CH.sub.2 Q.sub.1 H Me Me OMe N5971 CH.sub.2 Q.sub.1 H Et Me OMe CH5972 CH.sub.2 Q.sub.1 H Et OMe OMe CH5973 CH.sub.2 Q.sub.1 H Et Me OMe N5974 CH.sub.2 Q.sub.1 H H Me OMe CH5975 CH.sub.2 Q.sub.1 H H OMe OMe CH5976 CH.sub.2 Q.sub.1 H H Me OMe N5977 CH.sub.2 Q.sub.1 H COPh Me OMe CH5978 CH.sub.2 Q.sub.1 H COPh OMe OMe CH5979 CH.sub.2 Q.sub.1 H COPh Me OMe N5980 Me CH.sub.2 Q.sub.1 COOMe Me OMe CH5981 Me CH.sub.2 Q.sub.1 COOMe OMe OMe CH5982 Me CH.sub.2 Q.sub.1 COOMe Me OMe N5983 H H CH.sub.2 Q.sub.1 Me OMe CH5984 H H CH.sub.2 Q.sub.1 OMe OMe CH5985 H H CH.sub.2 Q.sub.1 Me OMe N5986 Me H CH.sub.2 Q.sub.1 Me Me CH5987 Me H CH.sub.2 Q.sub.1 Me OMe CH5988 Me H CH.sub.2 Q.sub.1 OMe OMe CH5989 Me H CH.sub.2 Q.sub.1 Me OMe N5990 Me H CH.sub.2 Q.sub.1 OMe OMe N5991 Me Me CH.sub.2 Q.sub.1 Me OMe CH5992 Me Me CH.sub.2 Q.sub.1 OMe OMe CH5993 Me Me CH.sub.2 Q.sub.1 Me OMe N5994 CHMeQ.sub.1 H COOMe Me OMe CH5995 CHMeQ.sub.1 H COOMe OMe OMe CH5996 CHMeQ.sub.1 H COOEt Me OMe CH5997 CHMeQ.sub.1 H COOEt OMe OMe CH5998 CHMeQ.sub.1 Me COOMe Me OMe CH5999 CHMeQ.sub.1 Me COOMe OMe OMe CH6000 CHMeQ.sub.1 Me COOEt Me OMe CH6001 CHMeQ.sub.1 Me COOEt OMe OMe CH6002 CHMeQ.sub.1 H H Me OMe CH6003 CHMeQ.sub.1 H H OMe OMe CH6004 Me H CHMeQ.sub.1 Me OMe CH6005 Me H CHMeQ.sub.1 OMe OMe CH6006 CH.sub.2 Q.sub.24 H COOMe Me Me CH6007 CH.sub.2 Q.sub.24 H COOMe Me OMe CH6008 CH.sub.2 Q.sub.24 H COOMe OMe OMe CH6009 CH.sub.2 Q.sub.24 H COOMe Me OMe N6010 CH.sub.2 Q.sub.24 H COOMe OMe OMe N6011 CH.sub.2 Q.sub.24 H COOEt Me Me CH6012 CH.sub.2 Q.sub.24 H COOEt Me OMe CH6013 CH.sub.2 Q.sub.24 H COOEt OMe OMe CH6014 CH.sub.2 Q.sub.24 H COOEt Me OMe N6015 CH.sub.2 Q.sub.24 H COOEt OMe OMe N6016 CH.sub.2 Q.sub.24 Me COOMe Me OMe CH6017 CH.sub.2 Q.sub.24 Me COOMe OMe OMe CH6018 CH.sub.2 Q.sub.24 Me COOMe Me OMe N6019 CH.sub.2 Q.sub.24 Me COOEt Me OMe CH6020 CH.sub.2 Q.sub.24 Me COOEt OMe OMe CH6021 CH.sub.2 Q.sub.24 Me COOEt Me OMe N6022 CH.sub.2 Q.sub.24 H CN Me OMe CH6023 CH.sub.2 Q.sub.24 H CN OMe OMe CH6024 CH.sub.2 Q.sub.24 H CN Me OMe N6025 CH.sub.2 Q.sub.24 H H Me OMe CH6026 CH.sub.2 Q.sub.24 H H OMe OMe CH6027 CH.sub.2 Q.sub.24 H H Me OMe N6028 Me H CH.sub.2 Q.sub.24 Me Me CH6029 Me H CH.sub.2 Q.sub.24 Me OMe CH6030 Me H CH.sub.2 Q.sub.24 OMe OMe CH6031 Me H CH.sub.2 Q.sub.24 Me OMe N6032 Me H CH.sub.2 Q.sub.24 OMe OMe N6033 CH.sub.2 Q.sub.28 H COOMe Me Me CH6034 CH.sub.2 Q.sub.28 H COOMe Me OMe CH6035 CH.sub.2 Q.sub.28 H COOMe OMe OMe CH6036 CH.sub.2 Q.sub.28 H COOMe Me OMe N6037 CH.sub.2 Q.sub.28 H COOMe OMe OMe N6038 CH.sub.2 Q.sub.28 H COOEt Me Me CH6039 CH.sub.2 Q.sub.28 H COOEt Me OMe CH6040 CH.sub.2 Q.sub.28 H COOEt OMe OMe CH6041 CH.sub.2 Q.sub.28 H COOEt Me OMe N6042 CH.sub.2 Q.sub.28 H COOEt OMe OMe N6043 CH.sub.2 Q.sub.28 Me COOMe Me OMe CH6044 CH.sub.2 Q.sub.28 Me COOMe OMe OMe CH6045 CH.sub.2 Q.sub.28 Me COOMe Me OMe N6046 CH.sub.2 Q.sub.28 Me COOEt Me OMe CH6047 CH.sub.2 Q.sub.28 Me COOEt OMe OMe CH6048 CH.sub.2 Q.sub.28 Me COOEt Me OMe N6049 CH.sub.2 Q.sub.28 H CN Me OMe CH6050 CH.sub.2 Q.sub.28 H CN OMe OMe CH6051 CH.sub.2 Q.sub.28 H CN Me OMe N6052 CH.sub.2 Q.sub.28 H H Me OMe CH6053 CH.sub.2 Q.sub.28 H H OMe OMe CH6054 CH.sub.2 Q.sub.28 H H Me OMe N6055 Me H CH.sub.2 Q.sub.28 Me Me CH6056 Me H CH.sub.2 Q.sub.28 Me OMe CH6057 Me H CH.sub.2 Q.sub.28 OMe OMe CH6058 Me H CH.sub.2 Q.sub.28 Me OMe N6059 Me H CH.sub.2 Q.sub.28 OMe OMe N6060 CH.sub.2 Q.sub.32 H COOMe Me Me CH6061 CH.sub.2 Q.sub.32 H COOMe Me OMe CH6062 CH.sub.2 Q.sub.32 H COOMe OMe OMe CH6063 CH.sub.2 Q.sub.32 H COOMe Me OMe N6064 CH.sub.2 Q.sub.32 H COOMe OMe OMe N6065 CH.sub.2 Q.sub.32 H COOEt Me Me CH6066 CH.sub.2 Q.sub.32 H COOEt Me OMe CH6067 CH.sub.2 Q.sub.32 H COOEt OMe OMe CH6068 CH.sub.2 Q.sub.32 H COOEt Me OMe N6069 CH.sub.2 Q.sub.32 H COOEt OMe OMe N6070 CH.sub.2 Q.sub.32 Me COOMe Me OMe CH6071 CH.sub.2 Q.sub.32 Me COOMe OMe OMe CH6072 CH.sub.2 Q.sub.32 Me COOMe Me OMe N6073 CH.sub.2 Q.sub.32 Me COOEt Me OMe CH6074 CH.sub.2 Q.sub.32 Me COOEt OMe OMe CH6075 CH.sub.2 Q.sub.32 Me COOEt Me OMe N6076 CH.sub.2 Q.sub.32 H CN Me OMe CH6077 CH.sub.2 Q.sub.32 H CN OMe OMe CH6078 CH.sub.2 Q.sub.32 H CN Me OMe N6079 CH.sub.2 Q.sub.32 H H Me OMe CH6080 CH.sub.2 Q.sub.32 H H OMe OMe CH6081 CH.sub.2 Q.sub.32 H H Me OMe N6082 Me H CH.sub.2 Q.sub.32 Me Me CH6083 Me H CH.sub.2 Q.sub.32 Me OMe CH6084 Me H CH.sub.2 Q.sub.32 OMe OMe CH6085 Me H CH.sub.2 Q.sub.32 Me OMe N6086 Me H CH.sub.2 Q.sub.32 OMe OMe N6087 CH.sub.2 CH.sub.2 Q.sub.1 H COOMe Me Me CH6088 CH.sub.2 CH.sub.2 Q.sub.1 H COOMe Me OMe CH6089 CH.sub.2 CH.sub.2 Q.sub.1 H COOMe OMe OMe CH6090 CH.sub.2 CH.sub.2 Q.sub.1 H COOMe Me OMe N6091 CH.sub.2 CH.sub.2 Q.sub.1 H COOMe OMe OMe N6092 CH.sub.2 CH.sub.2 Q.sub.1 H COOEt Me Me CH6093 CH.sub.2 CH.sub.2 Q.sub.1 H COOEt Me OMe CH6094 CH.sub.2 CH.sub.2 Q.sub.1 H COOEt OMe OMe CH6095 CH.sub.2 CH.sub.2 Q.sub.1 H COOEt Me OMe N6096 CH.sub.2 CH.sub.2 Q.sub.1 H COOEt OMe OMe N6097 CH.sub.2 CH.sub.2 Q.sub.1 Me COOMe Me OMe CH6098 CH.sub.2 CH.sub.2 Q.sub.1 Me COOMe OMe OMe CH6099 CH.sub.2 CH.sub.2 Q.sub.1 Me COOMe Me OMe N6100 CH.sub.2 CH.sub.2 Q.sub.1 Me COOEt Me OMe CH6101 CH.sub.2 CH.sub.2 Q.sub.1 Me COOEt OMe OMe CH6102 CH.sub.2 CH.sub.2 Q.sub.1 Me COOEt Me OMe N6103 CH.sub.2 CH.sub.2 Q.sub.1 H CN Me OMe CH6104 CH.sub.2 CH.sub.2 Q.sub.1 H CN OMe OMe CH6105 CH.sub.2 CH.sub.2 Q.sub.1 H CN Me OMe N6106 CH.sub.2 CH.sub.2 Q.sub.1 H H Me OMe CH6107 CH.sub.2 CH.sub.2 Q.sub.1 H H OMe OMe CH6108 CH.sub.2 CH.sub.2 Q.sub.1 H H Me OMe N6109 Me H CH.sub.2 CH.sub.2 Q.sub.1 Me Me CH6110 Me H CH.sub.2 CH.sub.2 Q.sub.1 Me OMe CH6111 Me H CH.sub.2 CH.sub.2 Q.sub.1 OMe OMe CH6112 Me H CH.sub.2 CH.sub.2 Q.sub.1 Me OMe N6113 Me H CH.sub.2 CH.sub.2 Q.sub.1 OMe OMe N__________________________________________________________________________
In the above, Q.sub.1 to Q.sub.32 are as defined above.
TABLE 12__________________________________________________________________________ ##STR38##No. A B D X Y Z__________________________________________________________________________6114 CH.sub.2 Q.sub.1 Me Cl Me Me CH6115 CH.sub.2 Q.sub.1 Me Cl Me OMe CH6116 CH.sub.2 Q.sub.1 Me Cl OMe OMe CH6117 CH.sub.2 Q.sub.1 Me Cl Me OMe N6118 CH.sub.2 Q.sub.1 Me Cl OMe OMe N6119 CH.sub.2 Q.sub.1 Me OMe Me OMe CH6120 CH.sub.2 Q.sub.1 Me OMe OMe OMe CH6121 CH.sub.2 Q.sub.1 Me OMe Me OMe N6122 CH.sub.2 Q.sub.1 CF.sub.3 Me Me OMe CH6123 CH.sub.2 Q.sub.1 CF.sub.3 Me OMe OMe CH6124 CH.sub.2 Q.sub.1 CF.sub.3 Me Me OMe N6125 CH.sub.2 Q.sub.1 Me COOMe Me Me CH6126 CH.sub.2 Q.sub.1 Me COOMe Me OMe CH6127 CH.sub.2 Q.sub.1 Me COOMe OMe OMe CH6128 CH.sub.2 Q.sub.1 Me COOMe Me OMe N6129 CH.sub.2 Q.sub.1 Me COOMe OMe OMe N6130 CH.sub.2 Q.sub.1 Me COOMe Me OCHF.sub.2 CH6131 CH.sub.2 Q.sub.1 Me COOMe Me ##STR39## CH6132 CH.sub.2 Q.sub.1 Me SO.sub.2 Me Me OMe CH6133 CH.sub.2 Q.sub.1 Me SO.sub.2 Me OMe OMe CH6134 CH.sub.2 Q.sub.1 Me SO.sub.2 Me Me OMe N6135 H CH.sub.2 Q.sub.1 Me Me OMe CH6136 H CH.sub.2 Q.sub.1 Me OMe OMe CH6137 H CH.sub.2 Q.sub.1 Me Me OMe N6138 Me CH.sub.2 Q.sub.1 Me Me OMe CH6139 Me CH.sub.2 Q.sub.1 Me OMe OMe CH6140 Me CH.sub.2 Q.sub.1 Me Me OMe N6141 Me CH.sub.2 Q.sub.1 Cl Me OMe CH6142 Me CH.sub.2 Q.sub.1 Cl OMe OMe CH6143 Me CH.sub.2 Q.sub.1 Cl Me OMe N6144 Me CH.sub.2 Q.sub.1 COOMe Me OMe CH6145 Me CH.sub.2 Q.sub.1 COOMe OMe OMe CH6146 Me CH.sub.2 Q.sub.1 COOMe Me OMe N6147 Me CH.sub.2 Q.sub.1 Ph Me OMe CH6148 Me CH.sub.2 Q.sub.1 Ph OMe OMe CH6149 Me CH.sub.2 Q.sub.1 Ph Me OMe N6150 Me Me CH.sub.2 Q.sub.1 Me OMe CH6151 Me Me CH.sub.2 Q.sub.1 OMe OMe CH6152 Me Me CH.sub.2 Q.sub.1 Me OMe N6153 CHMeQ.sub.1 Me COOMe Me OMe CH6154 CHMeQ.sub.1 Me COOMe OMe OMe CH6155 CHMeQ.sub.1 Me COOMe Me OMe N6156 Me Me CHMeQ.sub.1 OMe OMe CH6157 Me Me CHMeQ.sub.1 Me OMe N6158 CH.sub.2 Q.sub.24 Me COOMe Me Me CH6159 CH.sub.2 Q.sub.24 Me COOMe Me OMe CH6160 CH.sub.2 Q.sub.24 Me COOMe OMe OMe CH6161 CH.sub.2 Q.sub.24 Me COOMe Me OMe N6162 CH.sub.2 Q.sub.24 Me COOMe OMe OMe N6163 Me CH.sub.2 Q.sub.24 Me Me OMe CH6164 Me CH.sub.2 Q.sub.24 Me OMe OMe CH6165 Me CH.sub.2 Q.sub.24 Me Me OMe N6166 Me Me CH.sub.2 Q.sub.24 Me OMe CH6167 Me Me CH.sub.2 Q.sub.24 OMe OMe CH6168 Me Me CH.sub.2 Q.sub.24 Me OMe N6169 CH.sub.2 Q.sub.28 Me COOMe Me Me CH6170 CH.sub.2 Q.sub.28 Me COOMe Me OMe CH6171 CH.sub.2 Q.sub.28 Me COOMe OMe OMe CH6172 CH.sub.2 Q.sub.28 Me COOMe Me OMe N6173 CH.sub.2 Q.sub.28 Me COOMe OMe OMe N6174 Me CH.sub.2 Q.sub.28 Me Me OMe CH6175 Me CH.sub.2 Q.sub.28 Me OMe OMe CH6176 Me CH.sub.2 Q.sub.28 Me Me OMe N6177 Me Me CH.sub.2 Q.sub.28 Me OMe CH6178 Me Me CH.sub.2 Q.sub.28 OMe OMe CH6179 Me Me CH.sub.2 Q.sub.28 Me OMe N6180 CH.sub.2 Q.sub.32 Me COOMe Me Me CH6181 CH.sub.2 Q.sub.32 Me COOMe Me OMe CH6182 CH.sub.2 Q.sub.32 Me COOMe OMe OMe CH6183 CH.sub.2 Q.sub.32 Me COOMe Me OMe N6184 CH.sub.2 Q.sub.32 Me COOMe OMe OMe N6185 Me CH.sub.2 Q.sub.32 Me Me OMe CH6186 Me CH.sub.2 Q.sub.32 Me OMe OMe CH6187 Me CH.sub.2 Q.sub.32 Me Me OMe N6188 Me Me CH.sub.2 Q.sub.32 Me OMe CH6189 Me Me CH.sub.2 Q.sub.32 OMe OMe CH6190 Me Me CH.sub.2 Q.sub.32 Me OMe N6191 CH.sub.2 CH.sub.2 Q.sub.1 Me COOMe Me Me CH6192 CH.sub.2 CH.sub.2 Q.sub.1 Me COOMe Me OMe CH6193 CH.sub.2 CH.sub.2 Q.sub.1 Me COOMe OMe OMe CH6194 CH.sub.2 CH.sub.2 Q.sub.1 Me COOMe Me OMe N6195 CH.sub.2 CH.sub.2 Q.sub.1 Me COOMe OMe OMe N6196 Me CH.sub.2 CH.sub.2 Q.sub.1 Me Me OMe CH6197 Me CH.sub.2 CH.sub.2 Q.sub.1 Me OMe OMe CH6198 Me CH.sub.2 CH.sub.2 Q.sub.1 Me Me OMe N6199 Me Me CH.sub.2 CH.sub.2 Q.sub.1 Me OMe CH6200 Me Me CH.sub.2 CH.sub.2 Q.sub.1 OMe OMe CH6201 Me Me CH.sub.2 CH.sub.2 Q.sub.1 Me OMe N__________________________________________________________________________
In the above, Q.sub.1 to Q.sub.32 are as defined above.
TABLE 13______________________________________ ##STR40##No. A B D X Y Z______________________________________6202 CH.sub.2 Q.sub.1 H H Me OMe CH6203 CH.sub.2 Q.sub.1 H H OMe OMe CH6204 CH.sub.2 Q.sub.1 H H Me OMe N6205 CH.sub.2 Q.sub.1 Me H Me OMe CH6206 CH.sub.2 Q.sub.1 Me H OMe OMe CH6207 CH.sub.2 Q.sub.1 Me H Me OMe N6208 CH.sub.2 Q.sub.1 Cl H Me OMe CH6209 CH.sub.2 Q.sub.1 Cl H OMe OMe CH6210 CH.sub.2 Q.sub.1 Cl H Me OMe N6211 CH.sub.2 Q.sub.1 Br H Me OMe CH6212 CH.sub.2 Q.sub.1 Br H OMe OMe CH6213 CH.sub.2 Q.sub.1 Br H Me OMe N6214 CH.sub.2 Q.sub.1 COOMe H Me OMe CH6215 CH.sub.2 Q.sub.1 COOMe H OMe OMe CH6216 CH.sub.2 Q.sub.1 COOMe H Me OMe N6217 CH.sub.2 Q.sub.1 COOEt H Me OMe CH6218 CH.sub.2 Q.sub.1 COOEt H OMe OMe CH6219 CH.sub.2 Q.sub.1 COOEt H Me OMe N6220 Me CH.sub.2 Q.sub.1 H Me Me CH6221 Me CH.sub.2 Q.sub.1 H Me OMe CH6222 Me CH.sub.2 Q.sub.1 H OMe OMe CH6223 Me CH.sub.2 Q.sub.1 H Me OMe N6224 Me CH.sub.2 Q.sub.1 H OMe OMe N6225 COMe CH.sub.2 Q.sub.1 H Me OMe CH6226 COMe CH.sub.2 Q.sub.1 H OMe OMe CH6227 COMe CH.sub.2 Q.sub.1 H Me OMe N6228 CHMeQ.sub.1 Cl H Me OMe CH6229 CHMeQ.sub.1 Cl H OMe OMe CH6230 CHMeQ.sub.1 Cl H Me OMe N6231 CHMeQ.sub.1 COOMe H Me OMe CH6232 CHMeQ.sub.1 COOMe H OMe OMe CH6233 CHMeQ.sub.1 COOMe H Me OMe N6234 Me CHMeQ.sub.1 H Me OMe CH6235 Me CHMeQ.sub.1 H OMe OMe CH6236 Me CHMeQ.sub.1 H Me OMe N6237 CH.sub.2 Q.sub.24 H H Me OMe CH6238 CH.sub.2 Q.sub.24 H H OMe OMe CH6239 CH.sub.2 Q.sub.24 H H Me OMe N6240 CH.sub.2 Q.sub.24 Cl H Me OMe CH6241 CH.sub.2 Q.sub.24 Cl H OMe OMe CH6242 CH.sub.2 Q.sub.24 Cl H Me OMe N6243 CH.sub.2 Q.sub.24 COOMe H Me OMe CH6244 CH.sub.2 Q.sub.24 COOMe H OMe OMe CH6245 CH.sub.2 Q.sub.24 COOMe H Me OMe N6246 Me CH.sub.2 Q.sub.24 H Me OMe CH6247 Me CH.sub.2 Q.sub.24 H OMe OMe CH6248 Me CH.sub.2 Q.sub.24 H Me OMe N6249 CH.sub.2 Q.sub.28 H H Me OMe CH6250 CH.sub.2 Q.sub.28 H H OMe OMe CH6251 CH.sub.2 Q.sub.28 H H Me OMe N6252 CH.sub.2 Q.sub.28 Cl H Me OMe CH6253 CH.sub.2 Q.sub.28 Cl H OMe OMe CH6254 CH.sub.2 Q.sub.28 Cl H Me OMe N6255 CH.sub.2 Q.sub.28 COOMe H Me OMe CH6256 CH.sub.2 Q.sub.28 COOMe H OMe OMe CH6257 CH.sub.2 Q.sub.28 COOMe H Me OMe N6258 Me CH.sub.2 Q.sub.28 H Me OMe CH6259 Me CH.sub.2 Q.sub.28 H OMe OMe CH6260 Me CH.sub.2 Q.sub.28 H Me OMe N6261 CH.sub.2 Q.sub.32 H H Me OMe CH6262 CH.sub.2 Q.sub.32 H H OMe OMe CH6263 CH.sub.2 Q.sub.32 H H Me OMe N6264 CH.sub.2 Q.sub.32 Cl H Me OMe CH6265 CH.sub.2 Q.sub.32 Cl H OMe OMe CH6266 CH.sub.2 Q.sub.32 Cl H Me OMe N6267 CH.sub.2 Q.sub.32 COOMe H Me OMe CH6268 CH.sub.2 Q.sub.32 COOMe H OMe OMe CH6269 CH.sub.2 Q.sub.32 COOMe H Me OMe N6270 Me CH.sub.2 Q.sub.32 H Me OMe CH6271 Me CH.sub.2 Q.sub.32 H OMe OMe CH6272 Me CH.sub.2 Q.sub.32 H Me OMe N6273 CH.sub.2 CH.sub.2 Q.sub.1 H H Me OMe CH6274 CH.sub.2 CH.sub.2 Q.sub.1 H H OMe OMe CH6275 CH.sub.2 CH.sub.2 Q.sub.1 H H Me OMe N6276 CH.sub.2 CH.sub.2 Q.sub.1 Cl H Me OMe CH6277 CH.sub.2 CH.sub.2 Q.sub.1 Cl H OMe OMe CH6278 CH.sub.2 CH.sub.2 Q.sub.1 Cl H Me OMe N6279 CH.sub.2 CH.sub.2 Q.sub.1 COOMe H Me OMe CH6280 CH.sub.2 CH.sub.2 Q.sub.1 COOMe H OMe OMe CH6281 CH.sub.2 CH.sub.2 Q.sub.1 COOMe H Me OMe N6282 Me CH.sub.2 CH.sub.2 Q.sub.1 H Me OMe CH6283 Me CH.sub.2 CH.sub.2 Q.sub.1 H OMe OMe CH6284 Me CH.sub.2 CH.sub.2 Q.sub.1 H Me OMe N______________________________________
In the above, Q.sub.1 to Q.sub.32 are as defined above.
TABLE 14__________________________________________________________________________ ##STR41##No. A B D R.sup.16 X Y Z__________________________________________________________________________6285 Q.sub.1 H COOMe H Me OMe CH6286 Q.sub.1 H COOMe H OMe OMe CH6287 Q.sub.1 H COOEt H Me OMe CH6288 Q.sub.1 H COOEt H OMe OMe CH6289 Q.sub.1 Me COOMe H Me OMe CH6290 Q.sub.1 Me COOMe H OMe OMe CH6291 Q.sub.1 Me COOEt H Me OMe CH6292 Q.sub.1 Me COOEt H OMe OMe CH6293 Q.sub.1 H H H Me OMe CH6294 Q.sub.1 H H H OMe OMe CH6295 Me H Q.sub.1 H Me OMe CH6296 Me H Q.sub.1 H OMe OMe CH6297 Q.sub.1 H COOMe Me Me Me CH6298 Q.sub.1 H COOMe Me Me OMe CH6299 Q.sub.1 H COOMe Me OMe OMe CH6300 Q.sub.1 H COOMe Me Me OMe N6301 Q.sub.1 H COOMe Me OMe OMe N6302 Q.sub.1 H COOEt Me Me Me CH6303 Q.sub.1 H COOEt Me Me OMe CH6304 Q.sub.1 H COOEt Me OMe OMe CH6305 Q.sub.1 H COOEt Me Me OMe N6306 Q.sub.1 H COOEt Me OMe OMe N6307 Q.sub.1 Me COOMe Me Me OMe CH6308 Q.sub.1 Me COOMe Me OMe OMe CH6309 Q.sub.1 Me COOMe Me Me OMe N6310 Q.sub.1 Me COOEt Me Me OMe CH6311 Q.sub.1 Me COOEt Me OMe OMe CH6312 Q.sub.1 Me COOEt Me Me OMe N6313 Q.sub.1 H CN Me Me OMe CH6314 Q.sub.1 H CN Me OMe OMe CH6315 Q.sub.1 H CN Me Me OMe N6316 Q.sub.1 H H Me Me OMe CH6317 Q.sub.1 H H Me OMe OMe CH6318 Q.sub.1 H H Me Me OMe N6319 Me H Q.sub.1 Me Me Me CH6320 Me H Q.sub.1 Me Me OMe CH6321 Me H Q.sub.1 Me OMe OMe CH6322 Me H Q.sub.1 Me Me OMe N6323 Me H Q.sub.1 Me OMe OMe N6324 Q.sub.1 H COOMe Et Me OMe CH6325 Q.sub.1 H COOMe Et OMe OMe CH6326 Q.sub.1 H COOEt Et Me OMe CH6327 Q.sub.1 H COOEt Et OMe OMe CH6328 Q.sub.1 Me COOMe Et Me OMe CH6329 Q.sub.1 Me COOMe Et OMe OMe CH6330 Q.sub.1 Me COOEt Et Me OMe CH6331 Q.sub.1 Me COOEt Et OMe OMe CH6332 Q.sub.1 H H Et Me OMe CH6333 Q.sub.1 H H Et OMe OMe CH6334 Me H Q.sub.1 Et Me OMe CH6335 Me H Q.sub.1 Et OMe OMe CH6336 Q.sub.1 H COOMe OMe Me Me CH6337 Q.sub.1 H COOMe OMe Me OMe CH6338 Q.sub.1 H COOMe OMe OMe OMe CH6339 Q.sub.1 H COOMe OMe Me Me N6340 Q.sub.1 H COOMe OMe Me OMe N6341 Q.sub.1 H COOMe OMe OMe OMe N6342 Q.sub.1 H COOMe OMe Me OCHF.sub.2 CH6343 Q.sub.1 H COOMe OMe Cl OMe CH6344 Q.sub.1 H COOEt OMe Me Me CH6345 Q.sub.1 H COOEt OMe Me OMe CH6346 Q.sub.1 H COOEt OMe OMe OMe CH6347 Q.sub.1 H COOEt OMe Me Me N6348 Q.sub.1 H COOEt OMe Me OMe N6349 Q.sub.1 H COOEt OMe OMe OMe N6350 Q.sub.1 H COOEt OMe Me OCHF.sub.2 CH6351 Q.sub.1 H COOEt OMe Cl OMe CH6352 Q.sub.1 H COOPrn OMe Me OMe CH6353 Q.sub.1 H COOPrn OMe OMe OMe CH6354 Q.sub.1 H COOPrn OMe Me OMe N6355 Q.sub.1 H COOPri OMe Me OMe CH6356 Q.sub.1 H COOPri OMe OMe OMe CH6357 Q.sub.1 H COOPri OMe Me OMe N6358 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl OMe Me OMe CH6359 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl OMe OMe OMe CH6360 Q.sub.1 H COOCH.sub.2 CH.sub.2 Cl OMe Me OMe N6361 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 OMe Me OMe CH6362 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 OMe OMe OMe CH6363 Q.sub.1 H COOCH.sub.2 CHCH.sub.2 OMe Me OMe N6364 Q.sub.1 H COOCH.sub.2 CCH OMe Me OMe CH6365 Q.sub.1 H COOCH.sub.2 CCH OMe OMe OMe CH6366 Q.sub.1 H COOCH.sub.2 CCH OMe Me OMe N6367 Q.sub.1 Me COOMe OMe Me Me CH6368 Q.sub.1 Me COOMe OMe Me OMe CH6359 Q.sub.1 Me COOMe OMe OMe OMe CH6370 Q.sub.1 Me COOMe OMe Me OMe N6371 Q.sub.1 Me COOMe OMe OMe OMe N6372 Q.sub.1 Me COOEt OMe Me Me CH6373 Q.sub.1 Me COOEt OMe Me OMe CH6374 Q.sub.1 Me COOEt OMe OMe OMe CH6375 Q.sub.1 Me COOEt OMe Me OMe N6376 Q.sub.1 Me COOEt OMe OMe OMe N6377 Q.sub.1 Cl COOMe OMe Me OMe CH6378 Q.sub.1 Cl COOMe OMe OMe OMe CH6379 Q.sub.1 Cl COOMe OMe Me OMe N6380 Q.sub.1 Cl COOEt OMe Me OMe CH6381 Q.sub.1 Cl COOEt OMe OMe OMe CH6382 Q.sub.1 Cl COOEt OMe Me OMe N6383 Q.sub.1 OMe COOMe OMe Me OMe CH6384 Q.sub.1 OMe COOMe OMe OMe OMe CH6385 Q.sub.1 OMe COOMe OMe Me OMe N6386 Q.sub.1 OMe COOEt OMe Me OMe CH6387 Q.sub.1 OMe COOEt OMe OMe OMe CH6388 Q.sub.1 OMe COOEt OMe Me OMe N6389 Q.sub.1 H Cl OMe Me OMe CH6390 Q.sub.1 H Cl OMe OMe OMe CH6391 Q.sub.1 H Cl OMe Me OMe N6392 Q.sub.1 H NO.sub.2 OMe Me OMe CH6393 Q.sub.1 H NO.sub.2 OMe OMe OMe CH6394 Q.sub.1 H NO.sub.2 OMe Me OMe N6395 Q.sub.1 H SO.sub.2 NMe.sub.2 OMe Me OMe CH6396 Q.sub.1 H SO.sub.2 NMe.sub.2 OMe OMe OMe CH6397 Q.sub.1 H SO.sub.2 NMe.sub.2 OMe Me OMe N6398 Q.sub.1 H CN OMe Me OMe CH6399 Q.sub. 1 H CN OMe OMe OMe CH6400 Q.sub.1 H CN OMe Me OMe N6401 Q.sub.1 Me CN OMe Me OMe CH6402 Q.sub.1 Me CN OMe OMe OMe CH6403 Q.sub.1 Me CN OMe Me OMe N6404 Q.sub.1 H Me OMe Me OMe CH6405 Q.sub.1 H Me OMe OMe OMe CH6406 Q.sub.1 H Me OMe Me OMe N6407 Q.sub.1 H Et OMe Me OMe CH6408 Q.sub.1 H Et OMe OMe OMe CH6409 Q.sub.1 H Et OMe Me OMe N6410 Q.sub.1 H H OMe Me OMe CH6411 Q.sub.1 H H OMe OMe OMe CH6412 Q.sub.1 H H OMe Me OMe N6413 Q.sub.1 H COPh OMe Me OMe CH6414 Q.sub.1 H COPh OMe OMe OMe CH6415 Q.sub.1 H COPh OMe Me OMe N6416 Me Q.sub.1 COOMe OMe Me OMe CH6417 Me Q.sub.1 COOMe OMe OMe OMe CH6418 Me Q.sub.1 COOMe OMe Me OMe N6419 H H Q.sub.1 OMe Me OMe CH6420 H H Q.sub.1 OMe OMe OMe CH6421 H H Q.sub. 1 OMe Me OMe N6422 Me H Q.sub.1 OMe Me Me CH6423 Me H Q.sub.1 OMe Me OMe CH6424 Me H Q.sub.1 OMe OMe OMe CH6425 Me H Q.sub.1 OMe Me OMe N6426 Me H Q.sub.1 OMe OMe OMe N6427 Me Me Q.sub.1 OMe Me OMe CH6428 Me Me Q.sub.1 OMe OMe OMe CH6429 Me Me Q.sub.1 OMe Me OMe N6430 Q.sub.1 H COOMe OEt Me OMe CH6431 Q.sub.1 H COOMe OEt OMe OMe CH6432 Q.sub.1 H COOEt OEt Me OMe CH6433 Q.sub.1 H COOEt OEt OMe OMe CH6434 Q.sub.1 Me COOMe OEt Me OMe CH6435 Q.sub.1 Me COOMe OEt OMe OMe CH6436 Q.sub.1 Me COOEt OEt Me OMe CH6437 Q.sub.1 Me COOEt OEt OMe OMe CH6438 Q.sub.1 H H OEt Me OMe CH6439 Q.sub.1 H H OEt OMe OMe CH6440 Me H Q.sub.1 OEt Me OMe CH6441 Me H Q.sub.1 OEt OMe OMe CH6442 Q.sub.2 H COOMe OMe Me Me CH6443 Q.sub.2 H COOMe OMe Me OMe CH6444 Q.sub.2 H COOMe OMe OMe OMe CH6445 Q.sub.2 H COOMe OMe Me OMe N6446 Q.sub.2 H COOMe OMe OMe OMe N6447 Q.sub.2 H COOEt OMe Me Me CH6448 Q.sub.2 H COOEt OMe Me OMe CH6449 Q.sub.2 H COOEt OMe OMe OMe CH6450 Q.sub.2 H COOEt OMe Me OMe N6451 Q.sub.2 H COOEt OMe OMe OMe N6452 Q.sub.2 Me COOMe OMe Me OMe CH6453 Q.sub.2 Me COOMe OMe OMe OMe CH6454 Q.sub.2 Me COOMe OMe Me OMe N6455 Q.sub.2 Me COOEt OMe Me OMe CH6456 Q.sub.2 Me COOEt OMe OMe OMe CH6457 Q.sub.2 Me COOEt OMe Me OMe N6458 Q.sub.2 H CN OMe Me OMe CH6459 Q.sub.2 H CN OMe OMe OMe CH6460 Q.sub.2 H CN OMe Me OMe N6461 Q.sub.2 H H OMe Me OMe CH6462 Q.sub.2 H H OMe OMe OMe CH6463 Q.sub.2 H H OMe Me OMe N6464 Me H Q.sub.2 OMe Me Me CH6465 Me H Q.sub.2 OMe Me OMe CH6466 Me H Q.sub.2 OMe OMe OMe CH6467 Me H Q.sub.2 OMe Me OMe N6468 Me H Q.sub.2 OMe OMe OMe N6469 Q.sub.5 H COOMe OMe Me Me CH6470 Q.sub.5 H COOMe OMe Me OMe CH6471 Q.sub.5 H COOMe OMe OMe OMe CH6472 Q.sub.5 H COOMe OMe Me OMe N6473 Q.sub.5 H COOMe OMe OMe OMe N6474 Q.sub.5 H COOEt OMe Me Me CH6475 Q.sub.5 H COOEt OMe Me OMe CH6476 Q.sub.5 H COOEt OMe OMe OMe CH6477 Q.sub.5 H COOEt OMe Me OMe N6478 Q.sub.5 H COOEt OMe OMe OMe N6479 Q.sub.5 Me COOMe OMe Me OMe CH6480 Q.sub.5 Me COOMe OMe OMe OMe CH6481 Q.sub.5 Me COOMe OMe Me OMe N6482 Q.sub.5 Me COOEt OMe Me OMe CH6483 Q.sub.5 Me COOEt OMe OMe OMe CH6484 Q.sub.5 Me COOEt OMe Me OMe N6485 Q.sub.5 H CN OMe Me OMe CH6486 Q.sub.5 H CN OMe OMe OMe CH6487 Q.sub.5 H CN OMe Me OMe N6488 Q.sub.5 H H OMe Me OMe CH6489 Q.sub.5 H H OMe OMe OMe CH6490 Q.sub.5 H H OMe Me OMe N6491 Me H Q.sub.5 OMe Me Me CH6492 Me H Q.sub.5 OMe Me OMe CH6493 Me H Q.sub.5 OMe OMe OMe CH6494 Me H Q.sub.5 OMe Me OMe N6495 Me H Q.sub.5 OMe OMe OMe N6496 Q.sub.10 H COOMe OMe Me Me CH6497 Q.sub.10 H COOMe OMe Me OMe CH6498 Q.sub.10 H COOMe OMe OMe OMe CH6499 Q.sub.10 H COOMe OMe Me OMe N6500 Q.sub.10 H COOMe OMe OMe OMe N6501 Q.sub.10 H COOEt OMe Me Me CH6502 Q.sub.10 H COOEt OMe Me OMe CH6503 Q.sub.10 H COOEt OMe OMe OMe CH6504 Q.sub.10 H COOEt OMe Me OMe N6505 Q.sub.10 H COOEt OMe OMe OMe N6506 Q.sub.10 Me COOMe OMe Me OMe CH6507 Q.sub.10 Me COOMe OMe OMe OMe CH6508 Q.sub.10 Me COOMe OMe Me OMe N6509 Q.sub.10 Me COOEt OMe Me OMe CH6510 Q.sub.10 Me COOEt OMe OMe OMe CH6511 Q.sub.10 Me COOEt OMe Me OMe N6512 Q.sub.10 H CN OMe Me OMe CH6513 Q.sub.10 H CN OMe OMe OMe CH6514 Q.sub.10 H CN OMe Me OMe N6515 Q.sub.10 H H OMe Me OMe CH6516 Q.sub.10 H H OMe OMe OMe CH6517 Q.sub.10 H H OMe Me OMe N6518 Me H Q.sub.10 OMe Me Me CH6519 Me H Q.sub.10 OMe Me OMe CH6520 Me H Q.sub.10 OMe OMe OMe CH6521 Me H Q.sub.10 OMe Me OMe N6522 Me H Q.sub.10 OMe OMe OMe N6523 Q.sub.32 H COOMe OMe Me Me CH6524 Q.sub.32 H COOMe OMe Me OMe CH6525 Q.sub.32 H COOMe OMe OMe OMe CH6526 Q.sub.32 H COOMe OMe Me OMe N6527 Q.sub.32 H COOMe OMe OMe OMe N6528 Q.sub.32 H COOEt OMe Me Me CH6529 Q.sub.32 H COOEt OMe Me OMe CH6530 Q.sub.32 H COOEt OMe OMe OMe CH6531 Q.sub.32 H COOEt OMe Me OMe N6532 Q.sub.32 H COOEt OMe OMe OMe N6533 Q.sub.32 Me COOMe OMe Me OMe CH6534 Q.sub.32 Me COOMe OMe OMe OMe CH6535 Q.sub.32 Me COOMe OMe Me OMe N6536 Q.sub.32 Me COOEt OMe Me OMe CH6537 Q.sub.32 Me COOEt OMe OMe OMe CH6538 Q.sub.32 Me COOEt OMe Me OMe N6539 Q.sub.32 H CN OMe Me OMe CH6540 Q.sub.32 H CN OMe OMe OMe CH6541 Q.sub.32 H CN OMe Me OMe N6542 Q.sub.32 H H OMe Me OMe CH6543 Q.sub.32 H H OMe OMe OMe CH6544 Q.sub.32 H H OMe Me OMe N6545 Me H Q.sub.32 OMe Me Me CH6546 Me H Q.sub.32 OMe Me OMe CH6547 Me H Q.sub.32 OMe OMe OMe CH6548 Me H Q.sub.32 OMe Me Me N6549 Me H Q.sub.32 OMe Me OMe N6550 Me H Q.sub.32 OMe OMe OMe N__________________________________________________________________________
In the above, Q.sub.1 to Q.sub.32 are as defined above.
TABLE 15______________________________________Comp. No. m.p. (.degree.C.)______________________________________1 159.about.1602 166.about.166.53 182.about.18331 166.about.16747 154.about.15748 143.about.14549 140.about.14250 137.about.14051 133.about.13652 141.about.14553 147.about.15254 146.about.14955 175.about.17962 136.about.13975 106.about.10876 138.about.14177 144.about.14790 123.about.130137 102.about.104138 124.about.126139 150.about.152140 93.about.96408 172.about.174481 182.about.185490 152.about.156491 167.about.170492 165.about.168497 174.about.177917 123.about.124918 178.about.179919 194.about.1951369 162.about.1652127 110.about.1153621 168.about.1703622 180.about.1823623 196.about.1993624 174.about.1753625 176.about.1784151 173.about.1764152 216.about.2185258 139.about.1425305 102.about.105132 129.about.132134 129.about.132100 127.about.129105 149.about.152581 135.about.140583 167.about.171638 90.about.95640 181.about.184771 152.about.155772 169.about.173773 151.about.154862 161.about.163863 176.about.178864 191.about.193885 170.about.171886 140.about.141887 174.about.175892 154.about.1571359 159.about.1611361 180.about. 181895 128.about.131896 131.about.134969 178.5.about.179.52323 138.about.1401453 155.about.1571455 165.about.1672548 205.about.2072549 167.about.1712550 169.about.1722551 163.about.1652552 183.about.1852553 204.about.2075347 113.about.116288 197.about.199630 163.about.166632 173.about.175663 98.about.100666 108.about.111668 100.about.1035349 162.about.1665370 143.about.1465462 100.about.1035463 114.about.1175464 145.about.1475554 119.about.1215555 165.about.1685602 134.about.1376218 95.about.96605 125-128661 110-1131071 160-1611073 152-1535454 156-1595456 192-1946211 115-1182763 136-1396551 202-204110 159-161121 131-132126 135-1371485 158-1611487 177-180662 113-114______________________________________
In application of the compounds of this invention as herbicides, they can be applied by mixing with suitable carriers such as solid carriers, including for example clay, talc, bentonite, diatomaceous earth and others or liquid carriers, including for example water, alcohols (methanol, ethanol and the like), aromatic hydrocarbons (benzene, toluene, xylene and the like), chlorinated hydrocarbons, ethers, ketones, esters (ethyl acetate, etc.), acid amides (dimethylformamide, etc.) and others. They can be provided for practical use with addition of any desired additive selected from an emulsifier, a dispersing agent, a suspending agent, a wetting agent, a spreader and a stablizer and in any desired form such as a soluble concentrate, an emulsifiable concentrate, a wettable powder, a dust, a granule, a suspension concentrate, etc.
In the following, there are shown examples of formulations of herbicides containing the compounds of this invention as active ingredients, but they are not limitative of this invention. In the exemplary formulations shown below, "parts" mean "parts by weight".
______________________________________Exemplary Formulation 1: Wettable powder______________________________________Compound No. 3 of this invention 50 partsZiegleit A 46 parts(kaolin type clay; trade name; produced byZiegleit Kogyo Co., Ltd.)Solpol 5039 2 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)Carplex (anticaking agent) 2 parts(white carbon; trade name, produced by ShionogiSeiyaku Co., Ltd.)______________________________________
All of the above components are mixed and pulverized homogeneously to prepare a wettable powder.
______________________________________Exemplary Formulation 2: Wettable powder______________________________________Compound No. 49 of this invention 45 partsZiegleit A 51 parts(kaolin type clay; trade name; produced byZiegleit Kogyo Co., Ltd.)Solpol 5039 2 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)Carplex (anticaking agent) 4 parts(white carbon; trade name; produced by ShionogiSeiyaku Co., Ltd.)______________________________________
The above components are mixed and pulverized homogeneously to prepare a wettable powder.
______________________________________Exemplary Formulation 3: Emulsifiable concentrate______________________________________Compound No. 49 of this invention 2 partsXylene 78 partsDimethylformamide 15 partsSolpol 2680 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)______________________________________
The above components are homogeneously mixed to prepare an emulsifiable concentrate. In use, the above emulsifiable concentrate is diluted to 10 to 10,000 times and sprayed in an amount of the active ingredient of 0.005 to 10 kg per hectare.
______________________________________Exemplary Formulation 4: Suspension concentrate______________________________________Compound No. 1369 of this invention 25 partsAgrisol S-710 10 parts(nonionic surfactant;trade name; produced byKao-Atlas Co., Ltd.)Runox 1000 C 0.5 part(anionic surfactant; trade name; produced by TohoKagaku Co., Ltd.)1% Rodopol water 20 parts(thickener; trade name; produced by RohnePoulainc)Water 44.5 parts______________________________________
The above components are mixed homogeneously to provide a suspnsion concentrate preparation.
______________________________________Exemplary Formulation 5: Granule______________________________________Compound No. 3 of this invention 0.1 partBentonite 55 partsTalc 44.9 parts______________________________________
All of the above components are mixed and pulverized homogeneously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.
______________________________________Exemplary Formulation 6: Granule______________________________________Compound No. 408 of this invention 0.5 partBentonite 55.0 partsTalc 44.5 parts______________________________________
All of the above components are mixed and pulverized homogenerously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.
______________________________________Exemplary Formulation 7: Wettable powder______________________________________Compound No. 1 of this invention 10 partsZiegleit PFP 83 parts(kaolin type clay; trade name; produced byZiegleit Kogyo Co., Ltd.)Solpol 5039 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)Carplex (anticaking agent) 2 parts(white carbon; trade name; produced by ShionogiSeiyaku Co., Ltd.)______________________________________
The above components are mixed and pulverized homogeneously to prepare a wettable powder.
______________________________________Exemplary Formulation 8: Wettable powder______________________________________Compound No. 132 of this invention 20 partsZiegleit PFP 73 parts(kaolin type clay; trade name; produced byZiegleit Kogyo Co., Ltd.)Solpol 5039 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)Carplex (anticaking agent) 2 parts(white carbon; trade name; produced by ShionogiSeiyaku Co., Ltd.)______________________________________
The above components are mixed and pulverized homogeneously to prepare a wettable powder.
______________________________________Exemplary Formulation 9: Wettable powder______________________________________Compound No. 638 of this invention 30 partsZiegleit PFP 63 parts(kaolin type clay; trade name; produced byZiegleit Kogyo Co., Ltd.)Solpol 5039 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)Carplex (anticaking agent) 2 parts(white carbon; trade name; produced by ShionogiSeiyaku Co., Ltd.)______________________________________
The above components are mixed and pulverized homogeneously to prepare a wettable powder.
______________________________________Exemplary Formulation 10: Wettable powder______________________________________Compound No. 771 of this invention 40 partsZiegleit PFP 53 parts(kaolin type clay; trade name; produced byZiegleit Kogyo Co., Ltd.)Solpol 5039 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)Carplex (anticaking agent) 2 parts(white carbon; trade name; produced by ShionogiSeiyaku Co., Ltd.)______________________________________
The above components are mixed and pulverized homogeneously to prepare a wettable powder.
______________________________________Exemplary Formulation 11: Wettable powder______________________________________Compound No. 885 of this invention 50 partsZiegleit PFP 43 parts(kaolin type clay; trade name; produced byZiegleit Kogyo Co., Ltd.)Solpol 5039 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)Carplex (anticaking agent) 2 parts(white carbon; trade name; produced by ShionogiSeiyaku Co., Ltd.)______________________________________
The above components are mixed and pulverized homogeneously to prepare a wettable powder.
______________________________________Exemplary Formulation 12: Wettable powder______________________________________Compound No. 887 of this invention 50 partsZiegleit PFP 43 parts(kaolin type clay; trade name; produced byZiegleit Kogyo Co., Ltd.)Solpol 5039 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)Carplex (anticaking agent) 2 parts(white carbon; trade name; produced by ShionogiSeiyaku Co., Ltd.)______________________________________
The above components are mixed and pulverized homogeneously to prepare a wettable powder.
______________________________________Exemplary Formulation 13: Wettable powder______________________________________Compound No. 896 of this invention 60 partsZiegleit PFP 33 parts(kaolin type clay; trade name; produced byZiegleit Kogyo Co., Ltd.)Solpol 5039 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)Carplex (anticaking agent) 2 parts(white carbon; trade name; produced by ShionogiSeiyaku Co., Ltd.)______________________________________
The above components are mixed and pulverized homogeneously to prepare a wettable powder.
______________________________________Exemplary Formulation 14: Wettable powder______________________________________Compound No. 1359 of this invention 70 partsZiegleit PFP 23 parts(kaolin type clay; trade name; produced byZiegleit Kogyo Co., Ltd.)Solpol 5039 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)Carplex (anticaking agent) 2 parts(white carbon; trade name; produced by ShionogiSeiyaku Co., Ltd.)______________________________________
The above components are mixed and pulverized homogeneously to prepare a wettable powder.
______________________________________Exemplary Formulation 15: Wettable powder______________________________________Compound No. 1455 of this invention 80 partsZiegleit PFP 13 parts(kaolin type clay; trade name; produced byZiegleit Kogyo Co., Ltd.)Solpol 5039 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)Carplex (anticaking agent) 2 parts(white carbon; trade name; produced by ShionogiSeiyaku Co., Ltd.)______________________________________
The above components are mixed and pulverized homogeneously to prepare a wettable powder.
______________________________________Exemplary Formulation 16: Emulsifiable concentrate______________________________________Compound No. 863 of this invention 1 partXylene 79 partsDimethylformamide 15 partsSolpol 2680 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)______________________________________
The above components are homogeneously mixed to prepare an emulsifiable concentrate. In use, the above emulsifiable concentrate is diluted to 10 to 10,000 times and sprayed in an amount of the active ingredient of 0.005 to 10 kg per hectare.
______________________________________Exemplary Formulation 17: Emulsifiable concentrate______________________________________Compound No. 886 of this invention 1.5 partsXylene 78.5 partsDimethylformamide 15 partsSolpol 2680 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)______________________________________
The above components are homogeneously mixed to prepare an emulsifiable concentrate. In use, the above emulsifiable concentrate is diluted to 10 to 10,000 times and sprayed in an amount of the active ingredient of 0.005 to 10 kg per hectare.
______________________________________Exemplary Formulation 18: Emulsifiable concentrate______________________________________Compound No. 5347 of this invention 2 partsXylene 78 partsDimethylformamide 15 partsSolpol 2680 5 parts(mixture of nonionic surfactant and anionicsurfactant; trade name; produced by Toho KagakuCo., Ltd.)______________________________________
The above components are homogeneously mixed to prepare an emulsifiable concentrate. In use, the above emulsifiable concentrate is diluted to 10 to 10,000 times and sprayed in an amount of the active ingredient of 0.005 to 10 kg per hectare.
______________________________________Exemplary Formulation 19: Suspension concentrate______________________________________Compound No. 583 of this invention 10 partsAgrisol B-710 10 parts(nonionic surfactant; trade name; produced byKao-Atlas Co., Ltd.)Runox 1000 C 0.5 part(anionic surfactant; trade name; produced by TohoKagaku Co., Ltd.)1% Rodopol water 20 parts(thickener; trade name; produced by RohnePoulainc)Water 59.5 parts______________________________________
The above components are mixed homogeneously to provide a suspnsion concentrate preparation.
______________________________________Exemplary Formulation 20: Suspension concentrate______________________________________Compound No. 640 of this invention 20 partsAgrisol B-710 10 parts(nonionic surfactant; trade name; produced byKao-Atlas Co., Ltd.)Runox 1000 C 0.5 part(anionic surfactant; trade name; produced by TohoKagaku Co., Ltd.)1% Rodopol water 20 parts(thickener; trade name; produced by RohnePoulainc)Water 49.5 parts______________________________________
The above components are mixed homogeneously to provide a suspnsion concentrate preparation.
______________________________________Exemplary Formulation 21: Suspension concentrate______________________________________Compound No. 1361 of this invention 30 partsAgrisol B-710 10 parts(nonionic surfactant; trade name; produced byKao-Atlas Co., Ltd.)Runox 1000 C 0.5 part(anionic surfactant; trade name; produced by TohoKagaku Co., Ltd.)1% Rodopol water 20 parts(thickener; trade name; produced by RohnePoulainc)Water 39.5 parts______________________________________
The above components are mixed homogeneously to provide a suspnsion concentrate preparation.
______________________________________Exemplary Formulation 22: Suspension concentrate______________________________________Compound No. 1453 of this invention 40 partsAgrisol B-710 10 parts(nonionic surfactant; trade name; produced byKao-Atlas Co., Ltd.)Runox 1000 C 0.5 part(anionic surfactant; trade name; produced by TohoKagaku Co., Ltd.)1% Rodopol water 20 parts(thickener; trade name; produced by RohnePoulainc)Water 29.5 parts______________________________________
The above components are mixed homogeneously to provide a suspnsion concentrate preparation.
______________________________________Exemplary Formulation 23: Suspension concentrate______________________________________Compound No. 2323 of this invention 60 partsAgrisol B-710 10 parts(nonionic surfactant; trade name; produced byKao-Atlas Co., Ltd.)Runox 1000 C 0.5 part(anionic surfactant; trade name; produced by TohoKagaku Co., Ltd.)1% Rodopol water 10 parts(thickener; trade name; produced by RohnePoulainc)Water 19.5 parts______________________________________
The above components are mixed homogeneously to provide a suspnsion concentrate preparation.
______________________________________Exemplary Formulation 24: Granule______________________________________Compound No. 885 of this invention 0.05 partBentonite 55.0 partsTalc 44.95 parts______________________________________
All of the above components are mixed and pulverized homogeneously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.
______________________________________Exemplary Formulation 25: Granule______________________________________Compound No. 886 of this invention 0.2 partBentonite 55.0 partsTalc 44.8 parts______________________________________
All of the above components are mixed and pulverized homogeneously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.
______________________________________Exemplary Formulation 26: Granule______________________________________Compound No. 887 of this invention 1.0 partBentonite 55.0 partsTalc 44.0 parts______________________________________
All of the above components are mixed and pulverized homogeneously, then a little amount of water is added and the whole is stirred, kneaded and granulated by excluding granulator, then dried to prepare a granule.
If desired, the compound of this invention may be applied as a mixture with other kinds of herbicides, various insecticides, sterilizers or adjuvants during preparation or spraying In particular, when applied in beet fields, useful ones include phenmedipham, desmedipham, lenacil, pyrazone., ethofumesate and so on.
As the other kinds of herbicides mentioned above, there may be included those as described in Farm Chemicals Handbook, 70th Edition (1984).
The compounds of this invention can also be applied, in addition to the agricultural and horticultural fields such as farm fields, paddy fields, fruit gardens and the like, to athletic grounds, vacant lands, belts along railroads and others. The amounts of the herbicide to be applied, which may differ depending on the scenes to be applied, the time of application, the application method, the kinds of the objective grasses and the crops harvested, may generally range suitably from about 0.25 to about 10 kg per hectare. When applied to beets in particular, it may range suitably from 0.25 to 500 g/ha, preferably from 0.5 to 250 g/ha.
The following test examples are set forth for illustration of the utility of the compounds of this invention as herbicides.
TEST EXAMPLE 1
Herbicidal Effect Test by Soil Treatment
In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, and seeds of (A) rice (Oryza sativa), (B) barnyardgrass (Echinochloa crusgalli), (C) large crabgrass (Digitaria adscendens), (D) annual sedge (Cyperus microiria), (E) black nightshade (Solanum nigrum L.), (F) hairly galinosoga (Galinosoga ciliata), (G) rorippa ssp. (Rorippa atrovirens), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton (Gossypium) and (L) sugar beet (Beta vulgaris) were sown mixedly. After covering soil to about 1.5 cm over the seeds, herbicides were sprayed evenly on the soil surface to predetermined proportions of the active ingredient. In spraying, the wettable powder as shown in the foregoing exemplary formulations was diluted with water and sprayed over the entire surface by means of a small sprayer. Four weeks after spraying, the herbicidal effect on crops including rice, etc. and the various weeds were examined according to the judgement criteria shown below. The results are shown in Table 16.
Some of the compounds of this invention show the selectivity on certain crops.
______________________________________Judgement criteria:______________________________________5. . . Growth control rates of more than 90% (almostcompletely withered)4. . . Growth control rates of 70 to 90%3. . . Growth control rates of 40 to 70%2. . . Growth control rates of 20 to 40%1. . . Growth control rates of 5 to 20%0. . . Growth control rates of less than 5%(substantially no effect)______________________________________
The above growth control rates are determined by measuring the top fresh weights of the treated plants and those of the non-treated plants, and calculated from the following formula: ##EQU1##
TEST EXAMPLE 2
Herbicidal effect test by stem-leaf treatment
In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, seeds of (A) rice (Oryza sativa), (B) barnyardgrass (Echinochloa crusgalli), (C) large crabgrass (Digitaria adscendens), (D) annual sedge (Cyperus microiria), (E) black nightshade (Solanum nigrum L.), (F) hairly galinosoga (Galinosoga ciliata), (G) rorippa ssp. (Rorippa atrovirens), (H) corn (Zea mays), (I) wheat (Triticum vulgare), (J) soybean (Glysine max), (K) cotton (Gossypium) and (L) sugar beet (Beta vulgaris) were sown in shapes of spots, respectively, followed by covering of soil to about 1.5 cm over the seeds. After respective plants have grown to the second and the third leaf stage, herbicides were sprayed evenly onto the stem-leaf portion at predetermined proportions of the active ingredient.
In spraying, the wettable powder as shown in the foregoing exemplary formulations was diluted with water and sprayed over the entire surface of the stem-leaf portions of various weeds by means of a small sprayer.
Four weeks after spraying, the herbicidal effect on crops including rice, etc. and the various weeds were examined according to the judgement criteria as shown in Test example 1. The results are shown in Table 17.
TEST EXAMPLE 3
Agricultural chemical damage test on sugar beet
In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, and seeds of (L) sugar beet (Beta vulgaris), (M) cocklebar (Xanthium strumarium), (N) wild mustard (Sinapis arvensis), (E) black nightshade (Solanum nigrum L.) and (O) cleavers (Galium aparine)) were sown in shapes of spots, respectively, followed by covering of soil to about 1.5 cm over the seeds. After respective plants have grown to the second and the third leaf stage, herbicides were sprayed evenly onto the stem-leaf portion at predetermined proportions of the active ingredient.
On 20 days after treatment, the herbicidal effects on weeds and agricultural chemical damages on sugar beet were examined. The results are shown in Table 18.
TEST EXAMPLE 4
Agricultural chemical damage test on wheat
In a plastic box of 15 cm length, 22 cm width and 6 cm depth, there was placed a sterilized deluvium soil, and seeds of (I) wheat (Triticum vulgare) and (P) wild oat (Avena fatua) were sown in shapes of spots, respectively, followed by covering of soil to about 1.5 cm over the seeds. After respective plants have grown to the third and the fourth leaf stage, herbicides were sprayed evenly onto the stem-leaf portion at predetermined proportions of the active ingredient.
On 20 days after treatment, the herbicidal effects on weeds and agricultural chemical damages on wheat were examined. The results are shown in Table 19.
TABLE 16__________________________________________________________________________ Amount of active ingre- dientComp. appliedNo. kg/ha (A) (B) (C) (D) (E) (F) (G) (H) (I) (J) (K) (L)__________________________________________________________________________No. 3 0.02 5 5 5 5 5 5 5 5 0 5 5 -- 0.04 5 5 5 5 5 5 5 5 1 5 5 --No. 31 0.16 5 5 4 5 5 5 5 5 0 5 5 --No. 49 0.02 5 2 1 5 5 5 5 5 5 5 5 0 0.04 5 3 3 5 5 5 5 5 5 5 5 0 0.08 5 5 5 5 5 5 5 5 5 5 5 1No. 53 0.16 1 0 1 4 2 5 5 1 0 0 0 -- 0.32 2 1 2 5 3 5 5 2 1 1 1 --No. 139 0.02 5 2 2 5 5 5 5 5 5 5 5 0 0.04 5 4 3 5 5 5 5 5 5 5 5 0 0.08 5 5 5 5 5 5 5 5 5 5 5 1No. 408 0.16 2 4 1 5 3 5 5 5 0 3 3 --No. 490 0.08 4 4 4 4 5 5 5 3 3 1 1 -- 0.16 5 4 4 4 5 5 5 4 4 1 1 --No.491 0.02 0 3 3 4 4 4 5 4 3 3 3 -- 0.04 4 4 5 4 5 5 5 5 5 5 3 -- 0.08 5 5 5 5 5 5 5 5 5 5 4 --No. 492 0.02 5 4 2 5 5 5 5 5 5 5 5 -- 0.04 5 5 3 5 5 5 5 5 5 5 5 --No. 497 0.08 4 4 2 4 5 4 5 3 3 2 1 -- 0.16 5 4 3 4 5 5 5 4 5 3 3 --No. 1369 0.02 5 4 4 5 5 5 5 5 5 5 3 -- 0.04 5 5 5 5 5 5 5 5 5 5 5 --No. 3624 0.16 5 2 5 4 2 4 5 5 5 1 0 --No. 4151 0.04 2 0 3 2 0 0 5 2 0 0 0 -- 0.08 3 3 4 3 0 0 5 3 0 0 0 -- 0.16 4 4 5 5 0 0 5 4 0 0 0 --No. 5258 0.32 0 1 4 2 1 4 3 0 0 0 0 --No. 132 0.32 5 3 3 4 4 5 4 5 2 5 0 --No. 583 0.16 5 5 2 5 5 5 5 5 5 5 5 -- 0.32 5 5 3 5 5 5 5 5 5 5 5 --No. 638 0.04 5 4 5 5 5 5 5 5 5 5 5 -- 0.08 5 5 5 5 5 5 5 5 5 5 5 --No. 640 0.04 5 5 3 5 5 5 5 5 3 4 3 0 0.08 5 5 4 5 5 5 5 5 5 5 5 1No. 771 0.04 3 3 3 5 5 5 5 3 3 3 3 -- 0.08 4 4 4 5 5 5 5 4 4 4 4 --No. 772 0.04 5 5 5 5 5 5 5 5 5 5 5 -- 0.08 5 5 5 5 5 5 5 5 5 5 5 --No. 773 0.04 5 4 3 5 5 5 5 5 4 4 3 -- 0.08 5 5 4 5 5 5 5 5 5 5 4 --No. 862 0.08 4 3 2 5 5 5 5 5 2 4 2 -- 0.16 5 4 3 5 5 5 5 5 3 5 3 --No. 864 0.04 4 4 1 5 5 5 5 3 1 3 0 -- 0.08 5 5 2 5 5 5 5 4 3 4 1 --No. 885 0.08 5 4 3 5 5 5 5 5 0 5 1 -- 0.16 5 5 5 5 5 5 5 5 0 5 3 --No. 887 0.08 5 5 2 5 5 5 5 5 0 5 5 0 0.16 5 5 3 5 5 5 5 5 0 5 5 0No. 896 0.04 5 3 3 5 5 5 5 5 5 4 3 0 0.08 5 4 4 5 5 5 5 5 5 5 4 0No. 2323 0.04 5 3 5 5 5 5 5 5 0 1 0 0 0.08 5 4 5 5 5 5 5 5 0 2 0 0No. 1455 0.16 5 4 5 5 5 5 5 5 3 5 5 -- 0.32 5 4 5 5 5 5 5 5 4 5 5 --No. 100 0.02 5 2 1 5 5 5 5 5 5 5 5 0 0.04 5 3 3 5 5 5 5 5 5 5 5 0 0.08 5 5 5 5 5 5 5 5 5 5 5 0No. 105 0.02 5 2 1 5 5 5 5 5 5 5 5 0 0.04 5 3 3 5 5 5 5 5 5 5 5 0 0.08 5 5 5 5 5 5 5 5 5 5 5 0No. 630 0.02 0 3 2 5 5 5 5 5 0 5 4 -- 0.04 0 5 4 5 5 5 5 5 0 5 4 -- 0.08 2 5 5 5 5 5 5 5 0 5 5 --No. 632 0.02 0 4 3 5 5 5 5 5 0 5 5 0 0.04 0 5 4 5 5 5 5 5 0 5 5 0 0.08 2 5 5 5 5 5 5 5 0 5 5 0No. 668 0.02 5 4 4 5 5 5 5 5 4 5 5 0 0.04 5 5 5 5 5 5 5 5 5 5 5 0 0.08 5 5 5 5 5 5 5 5 5 5 5 1No. 892 0.02 5 4 3 5 5 5 5 5 3 5 5 0 0.04 5 5 4 5 5 5 5 5 5 5 5 0 0.08 5 5 5 5 5 5 5 5 5 5 5 0No. 2549 0.63 5 5 5 5 5 5 5 5 5 5 0 --No. 2550 0.63 5 5 5 5 5 5 5 5 5 5 0 --No. 2551 0.63 5 5 5 5 5 5 5 5 5 5 0 --No. 2552 0.63 5 5 5 5 5 5 5 5 5 5 0 --No. 5370 0.02 5 4 2 5 5 5 5 5 4 5 5 0 0.04 5 5 4 5 5 5 5 5 5 5 5 0 0.08 5 5 5 5 5 5 5 5 5 5 5 0__________________________________________________________________________
TABLE 17__________________________________________________________________________ Amount of active ingre- dientComp. appliedNo. kg/ha (A) (B) (C) (D) (E) (F) (G) (H) (I) (J) (K) (L)__________________________________________________________________________ 0.01 5 5 4 5 5 5 5 5 1 5 5 5No. 1 0.02 5 5 5 5 5 5 5 5 1 5 5 5 0.04 5 5 5 5 5 5 5 5 2 5 5 5No. 2 0.04 2 5 2 5 5 5 5 5 0 5 5 5 0.08 4 5 3 5 5 5 5 5 0 5 5 5 0.01 5 5 1 5 5 5 5 5 0 5 5 0No. 3 0.02 5 5 1 5 5 5 5 5 0 5 5 0 0.04 5 5 3 5 5 5 5 5 0 5 5 1 0.04 1 5 1 5 5 5 5 5 0 5 5 5No. 31 0.08 2 5 1 5 5 5 5 5 0 5 5 5 0.01 5 3 2 4 5 5 5 5 0 5 5 0No. 48 0.02 5 4 2 5 5 5 5 5 1 5 5 0 0.04 5 5 3 5 5 5 5 5 2 5 5 0 0.01 5 5 2 5 5 5 5 5 5 5 5 0No. 49 0.02 5 5 3 5 5 5 5 5 5 5 5 0 0.04 5 5 3 5 5 5 5 5 5 5 5 0No. 51 0.32 5 5 3 5 5 5 5 5 5 5 5 5 0.04 4 3 0 4 5 5 3 4 2 3 3 4No. 52 0.08 5 3 0 4 5 5 4 5 2 3 4 5 0.16 5 3 0 5 5 5 5 5 2 4 4 5No. 53 0.16 3 3 2 5 5 5 5 4 0 0 3 3 0.16 1 3 0 5 5 5 5 2 1 3 3 5No. 55 0.32 2 4 1 5 5 5 5 3 2 4 4 5 0.01 5 3 2 5 5 5 5 5 5 5 5 0No. 138 0.02 5 4 3 5 5 5 5 5 5 5 5 0 0.04 5 5 3 5 5 5 5 5 5 5 5 0 0.01 5 5 2 5 5 5 5 5 5 5 5 0No. 139 0.02 5 5 3 5 5 5 5 5 5 5 5 0 0.04 5 5 3 5 5 5 5 5 5 5 5 1No. 140 0.32 5 5 3 5 5 5 5 5 5 5 5 5 0.04 0 4 0 5 5 5 5 5 0 5 5 5No. 408 0.08 2 5 0 5 5 5 5 5 0 5 5 5 0.16 3 5 0 5 5 5 5 5 0 5 5 5 0.04 4 0 0 2 5 5 5 3 0 5 5 5No. 481 0.08 5 0 0 3 5 5 5 4 0 5 5 5 0.16 5 0 0 4 5 5 5 5 0 5 5 5 0.08 3 5 2 5 5 5 4 4 1 2 2 4No. 490 0.16 4 5 3 5 5 5 5 5 2 3 3 5 0.01 4 4 3 3 5 5 5 4 4 5 5 5No. 491 0.02 5 4 3 4 5 5 5 5 5 5 5 5 0.04 5 5 3 5 5 5 5 5 5 5 5 5 0.04 5 5 3 5 5 5 5 5 5 5 5 5No. 492 0.08 5 5 3 5 5 5 5 5 5 5 5 5 0.08 3 4 2 4 5 5 5 3 2 3 5 5No. 497 0.16 4 5 2 5 5 5 5 5 3 5 5 5 0.04 5 5 5 5 5 5 5 5 5 5 5 0No. 1369 0.08 5 5 5 5 5 5 5 5 5 5 5 1 0.08 2 3 2 2 5 5 4 5 1 4 3 0No. 2127 0.16 3 4 4 5 5 5 5 5 3 5 4 1 0.08 5 5 5 3 5 5 5 5 5 2 0 5No. 3624 0.16 5 5 5 4 5 5 5 5 5 3 0 5No. 3625 0.16 4 5 5 3 4 5 4 2 3 2 2 5 0.04 3 5 4 5 3 0 5 5 0 4 0 5No. 4151 0.08 4 5 5 5 4 1 5 5 2 5 0 5 0.16 5 5 5 5 5 2 5 5 3 5 1 5 0.04 0 4 2 4 2 2 5 5 0 3 0 5No. 4152 0.08 2 5 4 5 3 5 5 5 0 4 1 5 0.16 4 5 5 5 4 5 5 5 0 5 1 5No. 5258 0.32 2 4 2 4 5 5 4 1 1 3 4 3 0.02 5 5 3 5 5 5 5 5 0 5 3 5No. 132 0.04 5 5 3 5 5 5 5 5 1 5 4 5 0.04 5 5 2 5 5 5 5 5 5 5 5 2No. 583 0.08 5 5 3 5 5 5 5 5 5 5 5 4 0.04 5 5 3 5 5 5 5 5 1 5 5 5No. 638 0.08 5 5 4 5 5 5 5 5 2 5 5 5 0.02 5 5 2 5 5 5 5 5 2 5 5 1No. 640 0.04 5 5 2 5 5 5 5 5 4 5 5 1 0.08 5 5 3 5 5 5 5 5 5 5 5 2 0.04 5 5 2 3 5 4 5 3 3 5 4 5No. 771 0.08 5 5 3 4 5 5 5 4 4 5 5 5 0.04 4 5 2 4 5 5 5 5 4 5 4 5No. 772 0.08 5 5 4 5 5 5 5 5 5 5 5 5 0.04 3 5 2 4 5 5 5 4 4 5 5 5No. 773 0.08 5 5 3 5 5 5 5 5 5 5 5 5 0.04 5 5 2 4 5 5 5 4 4 5 4 5No. 862 0.08 5 5 3 5 5 5 5 5 4 5 5 5No. 863 0.32 5 5 2 4 5 5 4 5 2 5 5 3 0.04 4 5 2 4 5 5 5 4 2 4 3 3No. 864 0.08 5 5 3 4 5 5 5 4 3 5 5 4 0.01 0 5 1 5 5 5 5 3 0 5 5 5No. 885 0.02 1 5 2 5 5 5 5 5 0 5 5 5 0.04 2 5 3 5 5 5 5 5 0 5 5 5 0.16 0 5 1 5 5 4 4 4 0 4 3 1No. 886 0.32 0 5 1 5 5 5 5 5 0 4 5 1 0.01 0 5 1 5 5 5 5 5 0 5 5 0No. 887 0.02 2 5 1 5 5 5 5 5 0 5 5 1 0.04 3 5 2 5 5 5 5 5 0 5 5 1No. 1359 0.63 5 2 1 4 5 5 5 4 0 4 4 4 0.04 5 5 3 4 5 5 5 5 0 5 5 0No. 1361 0.08 5 5 4 5 5 5 5 5 0 5 5 1 0.02 4 4 2 5 5 5 5 5 0 5 4 0No. 896 0.04 5 5 3 5 5 5 5 5 1 5 5 1 0.08 5 5 4 5 5 5 5 5 2 5 5 2 0.04 5 5 2 5 5 5 5 5 0 4 3 4No. 2323 0.08 5 5 3 5 5 5 5 5 0 5 4 5 0.16 5 5 0 5 5 5 5 5 0 5 5 5No. 1453 0.32 5 5 1 5 5 5 5 5 0 5 5 5 0.04 5 5 3 5 5 5 5 5 5 5 5 5No. 1455 0.08 5 5 4 5 5 5 5 5 5 5 5 5 0.01 5 5 2 5 5 5 5 5 5 5 5 0No. 100 0.02 5 5 3 5 5 5 5 5 5 5 5 0 0.04 5 5 3 5 5 5 5 5 5 5 5 0 0.01 5 5 2 5 5 5 5 5 5 5 5 0No. 105 0.02 5 5 3 5 5 5 5 5 5 5 5 0 0.04 5 5 3 5 5 5 5 5 5 5 5 0No. 581 0.16 5 3 4 5 5 5 5 5 5 5 5 5 0.01 0 4 2 5 5 5 5 5 0 5 5 5No. 630 0.02 0 4 2 5 5 5 5 5 0 5 5 5 0.04 0 5 3 5 5 5 5 5 0 5 5 5 0.01 0 4 2 5 5 5 5 5 0 5 5 0No. 632 0.02 0 5 3 5 5 5 5 5 0 5 5 0 0.04 0 5 3 5 5 5 5 5 0 5 5 0 0.01 5 5 3 5 5 5 5 5 5 5 5 0No. 668 0.02 5 5 4 5 5 5 5 5 5 5 5 1 0.04 5 5 5 5 5 5 5 5 5 5 5 2 0.01 5 5 2 5 5 5 5 5 5 5 5 0No. 892 0.02 5 5 3 5 5 5 5 5 5 5 5 0 0.04 5 5 3 5 5 5 5 5 5 5 5 0No. 2549 0.32 5 5 4 5 5 5 5 5 5 5 1 5No. 2550 0.63 5 5 4 5 5 4 5 5 5 5 0 5No. 2551 0.32 5 5 4 5 5 5 5 5 5 5 1 5No. 2552 0.63 5 4 5 5 4 5 5 5 5 5 0 5 0.01 5 4 2 5 5 5 5 5 4 5 5 0No. 5370 0.02 5 5 3 5 5 5 5 5 5 5 5 0 0.04 5 5 3 5 5 5 5 5 5 5 5 0__________________________________________________________________________
TABLE 18______________________________________ Amount of active ingre- dientComp. appliedNo. kg/ha (M) (E) (N) (O) (L)______________________________________ 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 3 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 1 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 48 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 0 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 49 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 1 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 138 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 0 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 139 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 0 0.01 5 5 5 5 0No. 1369 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 1 0.04 5 5 5 5 0No. 2127 0.08 5 5 5 5 0 0.16 5 5 5 5 1 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 100 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 0 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 105 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 0 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 134 0.02 5 5 5 5 0 0.04 5 5 5 5 1 0.08 5 5 5 5 2 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 630 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 1 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 640 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 1 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 668 0.02 5 5 5 5 1 0.04 5 5 5 5 2 0.08 5 5 5 5 3 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 887 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 1 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 892 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 1 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 896 0.02 5 5 5 5 0 0.04 5 5 5 5 1 0.08 5 5 5 5 2 0.01 5 5 5 5 0No. 1361 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 1 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 1455 0.02 5 5 5 5 0 0.04 5 5 5 5 1 0.08 5 5 5 5 2 0.01 5 5 5 5 0No. 5349 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 1 0.005 5 5 5 5 0 0.01 5 5 5 5 0No. 5370 0.02 5 5 5 5 0 0.04 5 5 5 5 0 0.08 5 5 5 5 1______________________________________
TABLE 19______________________________________ Amount of active ingre- dientComp. appliedNo. kg/ha (I) (P)______________________________________ 0.01 0 41 0.02 0 5 0.04 0 5 0.01 0 4132 0.02 0 5 0.04 0 5______________________________________

Number	Date	Country
60-6800	Jan 1985	JPX
60-78784	Apr 1985	JPX
60-236780	Oct 1985	JPX

Number	Name	Date	Kind
4534790	Wolf	Aug 1985
4705558	Hartzell	Nov 1987

Wheat growing process utilizing selective herebicide

Information

Patent Number

Date Filed

Date Issued

Inventors

Original Assignees

Examiners

Agents

CPC

US Classifications

Field of Search

US

International Classifications

Abstract

Description

Claims

Priority Claims (3)

Parent Case Info

US Referenced Citations (2)

Foreign Referenced Citations (1)

Divisions (1)