Patent Grant
10994149
Various devices are used within the body for a multitude of therapeutic applications. For instance, devices may be used to deliver stimulatory signals, record vital signs, perform pacing or defibrillation operations, record action potential activity from targeted tissue, control drug release from time-release capsules or drug pump units, or interface with the auditory system to assist with hearing. Typically, a subcutaneous battery operated implantable pulse generator (IPG) or other charge storage mechanism is used to provide power to a device.
However, devices which utilize a battery or other charge storage component are no longer functional once the battery or charge storage component can no longer retain charge. Consequently, for an implanted device, a patient would need to undergo a subsequent surgical procedure to obtain a replacement device. In addition, rechargeable IPGs cannot typically administer therapy while the unit is being recharged.
By utilizing the technology incorporated within the implantable wireless power receiver, which does not rely upon a battery or other charge storage device for operation, the life of an implanted device is no longer limited by the life of the battery or the ability to store charge. Further, such technology facilitates a smaller form factor, which results in a less invasive surgical procedure for placement of the device, and helps to reduce scarring from a reduction in the amount of bodily tissue in contact with the implanted device.
One embodiment of the present disclosure relates to a wireless implantable power receiver for use with a medical stimulation or monitoring device. The wireless implantable power receiver includes one or more non-inductive antennas and electronic circuitry. The one or more non-inductive antennas are configured to receive radiated energy, and the electronic circuitry is configured to convert the radiated energy received by the one or more non-inductive antennas to a DC power supply to provide power to a medical stimulation or monitoring device. The DC power supply operatively powers the medical stimulation or monitoring device such that the medical stimulation or monitoring device does not require the use of battery power or wired power from another power source. In one embodiment, the electronic circuitry configured to generate a DC power supply further includes a rectification circuitry and a smoothing circuitry. The rectification circuitry and the smoothing circuitry may be passive and further include one or more diodes. The smoothing circuitry may further include one or more resistors and one or more capacitors. The electronic circuitry may provide up to 10 Volts DC power to the medical stimulation or monitoring device. The wireless implantable power receiver may be physically integrated within an enclosure of the medical stimulation or monitoring device. The electronic circuitry may deliver power to a plurality of sensors of the medical stimulation or monitoring device.
Another embodiment of the present disclosure relates to a wireless implantable power receiver for a medical stimulation or monitoring device. The receiver includes one or more non-inductive antennas configured to receive radiated energy. The receiver further includes electronic circuitry configured to convert the radiated energy received by the one or more non-inductive antennas. The radiated energy may be converted into one of a DC power supply to provide power to the medical stimulation or monitoring device; a signal to provide parameter settings to the medical stimulation and monitoring device; a waveform to provide stimulatory signals to a tissue; or any combination thereof. The conversion of energy received by the one or more non-inductive antennas may provide the primary source of power to the medical stimulation or monitoring device. The receiver may be enclosed in a housing shared by the medical stimulation and monitoring device. An outside diameter of the receiver may be less than an inside diameter of a 14 gauge cannula or syringe. The receiver may include a conditioning circuitry configured to condition the received energy. At least one of the non-inductive antennas may include conductive trace on one of the circuits. At least one of the non-inductive antennas may be fabricated as a conductive wire connected to one of the circuits. The one or more non-inductive antennas may have a length ranging from about 100 microns to about 10 cm. The one or more non-inductive antennas may have a thickness ranging from about 20 microns to about 3 mm. The one or more non-inductive antennas receive frequencies from about 300 MHz to about 8 GHz. The parameter settings distributed to the device may include frequency, amplitude and duration parameters. The receiver may further include electronic circuitry to transmit signals recorded by the device to a remote system for storage or processing. The remote system may process signals transmitted by the receiver, to produce parameter signals, tissue stimulation signals, or both, which are transmitted to the implantable power receiver for distribution to elements of the device. A system including a plurality of wireless implantable power receivers, in which each wireless implantable power receiver is arranged in series, with respect to one another, may produce a power supply that is greater than 10 Volts DC power.
Another embodiment of the present disclosure relates to a system for use with a medical device. The system includes one or more medical stimulation or monitoring devices. The system further includes one or more non-inductive antennas configured to receive radiated energy. The system further includes electronic circuitry configured to convert the radiated energy received by the one or more non-inductive antennas into: (i) a DC power supply to provide power to the one or more medical stimulation or monitoring devices; (ii) a signal to provide parameter settings to the one or more medical stimulation or monitoring devices; (iii) a waveform to provide stimulatory signals to a tissue via a conductor implanted near the tissue; or (iv) any combination thereof. The one or more medical stimulation or monitoring devices is selected from the group consisting of: (a) a glucose monitor; (b) a cardiac device for monitoring, pacemaking or defibrillation; (c) one or more internal sensors for measuring vital signs; (d) one or more external sensors, such as EEG or ECG sensors, for measuring electrical activity; (e) microwires which measure action potential activity; (f) a time-release capsule or a drug-release device; (g) a cochlear lead; and (h) a deep brain stimulation device.
Another embodiment relates to a medical device system. The medical device system includes a medical stimulation or monitoring device and a wireless implantable power receiver. The wireless implantable power receiver includes one or more non-inductive antennas and electronic circuitry. The one or more non-inductive antennas are configured to receive radiated energy. The electronic circuitry is configured to convert the radiated energy received by the one or more non-inductive antennas to a DC power supply to provide power to the medical stimulation or monitoring device. The medical stimulation or monitoring device may exclude one or more electrodes configured to apply one or more electrical pulses to a neural tissue associated with the spinal column. The electronic circuitry configured to generate a DC power supply may further include a rectification circuitry and a smoothing circuitry. The rectification circuitry and the smoothing circuitry may be passive. The rectification circuitry may further include one or more diodes. The smoothing circuitry may further include one or more resistors and one or more capacitors. The wireless implantable power receiver may be configured to provide up to 10 Volts DC power. The wireless implantable power receiver may be physically integrated within the body of the medical stimulation or monitoring device. The wireless implantable power receiver may be tethered by one or more wires to the medical stimulation or monitoring device. The wireless implantable power receiver may provide power to a plurality of sensors within the medical stimulation or monitoring device.
Another embodiment of the present disclosure relates to a method of delivering electrical signals to power to a medical stimulation or monitoring device. The method includes enclosing the implantable wireless power receiver within the medical stimulation or monitoring device, implanting the receiver and the medical stimulation or monitoring device into tissue, receiving and converting radiated energy into a DC power supply for distribution to the medical stimulation or monitoring device, and operating the medical stimulation or monitoring device without receiving power from a source other than the DC power supply. The receiving step may be completed using non-inductive antennas. The power may provided to the medical stimulation or monitoring device without receiving power from a battery for the medical stimulation or monitoring device and without receiving power from a battery of the receiver. The method may further include using radiated energy received by one or more non-inductive antennas and converting the radiated energy using electronic circuitry into a parameter input for distribution to the device, and delivering the parameter input to the device. The parameter may have at least three different possible values. The method may further include receiving radiated energy from one or more non-inductive antennas and converting the radiated energy using electronic circuitry into an electrical waveform suitable for tissue simulation, and delivering the waveform to the device for distribution into the tissue, and stimulating the tissue.
The systems, methods and apparatus described in this application relate to transmitting and modulating energy and signals into and through a wireless power receiver that is fully contained within the body of an implantable device. The wireless implantable power receiver can include one or more non-inductive antennas for receiving wireless or radiated energy from a remote source. The wireless implantable power receiver can also include one or more electronic circuits for harnessing the wireless energy and transforming such energy into a power source that is routed to the other elements of the device that provide therapeutic function or monitoring. The wireless implantable power receiver (herein referred to as “receiver”) may be used to power medical devices (e.g., implantable medical stimulation and/or monitoring devices, devices which include neurostimulation functions, pacing, identification, telemetry, sensing or other body monitoring functions, etc.).
Embodiments of the present invention include a system for providing power in a form factor that can be fully contained within a device, along with parameter information embedding on an analog waveform(s) when applicable. Such a system may further be easily placed within tissue or reside within close contact to the targeted tissue. Additionally, such a system can reside at a location in which electrical signals from electrical radiative coupling is adequately received by the system at various tissue depths. Such a system is preferably wireless, and does not use cables or inductive coupling to power the implantable power receiver. Such a system may not use, contain, or rely on wired connectors or connector pads (e.g., a providing a physical electrical connection, providing close inductive coupling, etc.).
One embodiment relates to a wireless implantable power receiver including one or more non-inductive antennas and electronic circuitry. The one or more non-inductive antennas are configured to receive radiated energy. The electronic circuitry is configured to convert the radiated energy received by the one or more non-inductive antennas to a DC power supply to provide power to the device. The medical device can exclude a connector for receiving a wire or for receiving power from a source other than the DC power supply. In some embodiments, the power supplied by the DC power supply based on the radiated energy received is sufficient to power the medical device without supplemental power. In an exemplary embodiment, the medical device does not include a long term battery for energy storage but rather uses the “live” receipt of energy at the antenna to power the circuitry and to power the medical device's primary function.
In some embodiments, the wireless implantable power receiver is not connected indirectly via a length of thin wire to a lead containing electrodes for stimulation of tissues associated with the spinal column, but, instead, is fully integrated into an overall system in which the wireless implantable power receiver provides power directly to a component or device, which is itself implantable. A wireless implantable power receiver can attach directly to a component or device (e.g., medical device) that is in need of a DC power supply. In other embodiments, the receiver may provide power to a plurality of sensors distributed throughout a device. In still other embodiments, a plurality of receivers are arranged in series, with respect to one another, to produce a power supply that is greater than 10 Volts DC power.
Another embodiment relates to a wireless implantable power receiver including one or more non-inductive antennas configured to receive radiated energy. The receiver can also include electronic circuitry configured to convert the radiated energy received by the one or more non-inductive antennas into: (i) a DC power supply to provide power to one or more devices; (ii) a signal to provide parameter settings to the device; (iii) a waveform to provide stimulatory signals to a tissue; or (iv) any combination thereof. The receiver can exclude a wired connector for receiving the power.
A wireless implantable power receiver includes one or more non-inductive antennas and electronic circuitry, in which the one or more non-inductive antennas are configured to receive radiated energy, and the electronic circuitry is configured to convert the radiated energy received by the one or more non-inductive antennas to a DC power supply to provide power to one or more devices, wherein the device excludes one or more electrodes configured to apply one or more electrical pulses to a neural tissue associated with the spinal column.
Accordingly, the present invention provides a wireless implantable power receiver system. The system includes an enclosure, the enclosure housing, and one or more non-inductive antenna(s) configured to receive, from a remote antenna through electrical radiative coupling, an input signal containing electrical energy. The system further includes one or more circuits electrically connected to the one or more non-inductive antenna(s), configured to convert the electrical energy contained in an input signal to a DC constant power source. The enclosure, in certain embodiments, is shaped and arranged for delivery into a subject's body through an introducer or needle. In another embodiment, a relay antenna which is physically separate from the remote antenna is used to transmit energy to the implantable power receiver. In still another embodiment, the implantable power receiver may additionally deliver parameters to a device, or waveforms to tissue, or both. Distinctively, the invention disclosed here does not connect to a separate device as detailed in provisional U.S. patent application, 61/733,867, which utilizes a connector to provide power only to an attached device. Embodiments of the present invention can provide, not only power, but also parameter sets and instructions to circuitry (e.g., circuitry of the medical stimulation or monitoring device). The receiver circuitry and the medical device circuitry can be contained within the same housing or enclosure, according to an exemplary embodiment.
Further descriptions of exemplary wireless systems for providing neural stimulation to a patient can be found in co-pending published PCT applications PCT/US2012/23029 filed Jan. 27, 2012, PCT/US2012/32200 filed Apr. 4, 2012, PCT/US2012/48903, filed Jul. 30, 2012, PCT/US2012/50633, filed Aug. 13, 2012 and PCT/US2012/55746, filed Sep. 17, 2012, the complete disclosures of which are hereby incorporated by reference in their entirety for all purposes.
In still another embodiment of the invention, one or more circuits of the implantable power receiver, preferably, include only passive components. In another embodiment, the rectification circuitry and the smoothing circuitry are passive. In yet other embodiments, the one or more circuits are active (e.g., an active integrated circuit, field programmable gate array, or another active controller that can be powered for a brief period of time and conduct its task using power provided by the receiver circuitry).
In yet another embodiment of the invention, the implantable power receiver, preferably, does not include connectors (e.g., wired connectors) or connector pads (e.g., inductive pads), differentiating the device from the prior art. In still further embodiments, the implantable power receiver does not include a built-in long term storage battery. In still further embodiments, neither the receiver nor the medical device powered by the receiver contains a long term storage battery. In still further embodiments, the receiver and/or the medical device contain a battery used for backup purposes or other secondary purposes while the primary power is provided via the receiver circuitry.
Internal circuitry of the implanted wireless receiver system functions to provide power to the device electronics within the enclosure and to convert the incoming wireless energy signal (e.g. radiated energy) into an electrical waveform, or to distribute to portions of the device.
In one embodiment, the internal circuitry may include one or a plurality of diodes. It should be noted that diodes function to rectify the wireless signal, such as a sinusoidal signal, received by the non-inductive antenna(s). The diodes have a low threshold voltage to maximize the energy used for creating waveforms and power. Additionally, the circuitry may include a charge balancing microelectronic component to reduce or prevent corrosion as well as a current limiter.
In certain embodiments, the circuitry may include one or more non-inductive antennas, a rectifier, a charge balancer, a current limiter, a controller, and a device interface. In brief, the rectifier functions to rectify the signal received by the one or more non-inductive antennas. The rectified signal may be fed to the controller for receiving encoded instructions from a RF pulse generator module. The rectified signal may also be fed to a charge balance component that is configured to create one or more electrical pulses such that the one or more electrical pulses result in a substantially zero net charge (that is, the pulses are charge balanced). The charge balanced pulses are passed through the current limiter to the device interface. An example of this type of circuitry is described in additional detail in PCT/US2012/023029, which is fully incorporated by reference. The reader is referred to this published international application for additional details. Additionally, the reader is referred to published U.S. Application 2012/0330384, which is also fully incorporated by reference.
In other embodiments of the presently claimed invention, the implantable power receiver is not connected to electrodes configured to apply one or more electrical pulses to a neural tissue associated with the spinal column.
In still another embodiment, the wireless implantable power receiver does not include a connector or one or more connector pads. The reader is referred to published international application PCT/US2012/032200, which is also incorporated by reference, for additional details.
A telemetry signal may be transmitted to the implantable power receiver to deliver parameters to the device. The telemetry signal may be sent by modulation of a carrier signal. The telemetry signal does not interfere with the received input signal which is transformed into a DC power supply to power the device. In one embodiment, the telemetry signal and powering signal are combined into one signal; separate electronic subsystems harness the power contained in the signal and extract the data content of the signal.
An RF pulse generator system may be located externally to the body or implanted within tissue remotely from the implanted power receiver. The RF pulse generator system can, in certain embodiments, store parameters that are transmitted to an implanted power receiver via a remote antenna.
In preferred embodiments, the implantable power receiver is integrated or embedded within the device to which it provides power. In other embodiments, the power receiver may be tethered to a device through a conductive wire. The receiver may be tethered by one or more wires to a separate device, not by a connector. In still other embodiments, the device is physically integrated within a medical device enclosure.
The implanted power receiver system can include an enclosure that houses one or more non-inductive antennas (for example, dipole or patch antennas), include internal circuitry including microelectronics for electrical energy rectification, and be connected to an implanted device or device in close contact with human tissue.
In certain embodiments, at least one of the antennas can be constructed as a conductive trace feature contained on one of the circuits. In another embodiment, at least one of the antennas can be fabricated as a conductive wire connected to one of the circuits.
In various embodiments, the implantable power receiver is powered wirelessly (and therefore does not require a wired connection) and contains the circuitry necessary to receive pulse instructions and waveforms or other signals from a source external to the body. For example, various embodiments employ non-inductive, for example, dipole or other antenna configuration(s), to receive RF power through electrical radiative coupling.
Furthermore, the electrical radiative coupling mechanism (for example, a dipole antenna) can be utilized to improve the form factor of a wireless implantable power receiver and allow for miniature diameters, as small as 30 microns. Other implementations can have diameters of less than 1.3 mm, or as small as 300 microns.
Electrical radiative coupling also allows for the transmission and reception of energy at greater depths with less degradation in efficiency than inductive coil techniques. This can provide an advantage over devices that employ inductive coupling since the efficiency of such implants is highly dependent on the distance separating the external transmitter coil and the implanted receiver coil.
Various energy-coupling structures are included in this invention. Some embodiments have only one non-inductive antenna; other embodiments have one or more non-inductive antennas, or a plurality of non-inductive antennas of any given width. For example, without limitation, some embodiments have between three and ten non-inductive antennas, while other embodiments can have more than ten non-inductive antennas. Still other embodiments can have more than twenty non-inductive antennas.
In another embodiment, the non-inductive antenna(s) and the microelectronics can be placed singularly or in a multitude.
The antenna is a non-inductive antenna and is configured to receive, through electrical radiative coupling, an input signal containing electrical energy. In certain embodiments, the source of radiative energy is physically separate from the implantable power receiver. That is, the source is remote from the implantable power receiver, and the source itself transmits the energy, for example, electromagnetic radiation, wirelessly. Of course, the source of radiated energy is positioned at some proximity (but not physically in contact with or electrically connected by wires) to the implantable power receiver so that the one or more non-inductive antennas can receive the radiated energy.
Embodiments of this disclosure use electrical coupling and high frequencies to penetrate tissue mediums without direct contact of the transmission antenna to the body, as described and incorporated by reference in PCT Application PCT/US2012/023029.
In various embodiments, the implantable power receiver may be used to receive radiated energy from a remote source and provide power, parameters and waveforms to a device without using cables or inductive coupling to power the implantable power receiver.
The antenna can be, for example, a dipole antenna. Some embodiments may have only one dipole antenna, other embodiments may have multiple antennas of any given length. For example, without limitation, some embodiments may have between two and ten dipole antennas, while other embodiments can have more than ten dipole antennas or more than twenty dipole antennas.
In other embodiments, the implantable power receiver system may include up to ten non-inductive antennas within the enclosure, each independently having a length ranging from one-quarter of a centimeter to twelve centimeters.
In some other embodiments, a dipole antenna or non-inductive antenna can range from about 100 microns to about 10 cm in length. In other embodiments, a non-inductive antenna can range from 0.25 cm to 12 cm in length.
In other embodiments, a non-inductive antenna can consist of any linear non-inductive configuration ranging from 1 mm to 4 mm in thickness. In other embodiments, a non-inductive antenna can consist of any linear dipole configuration ranging from about 20 microns to about 3 mm in thickness.
The antenna may also be a folded dipole antenna instead of a straight dipole antenna.
In another embodiment, the one or more non-inductive antennas may receive frequencies from about 300 MHz to about 8 GHz. In still another embodiment, the one or more non-inductive antennas may receive frequencies from about 800 MHz to about 5.8 GHz.
The signal received by an antenna is transmitted to a rectification block for rectification. The output signal of the rectifier is connected in parallel with a resistor and DC storage capacitor. The DC storage capacitor helps to smooth the rectified waveform and provide a constant power supply to a device. In one embodiment, the electronic circuitry is configured to generate a DC power supply further including a rectification circuitry and a smoothing circuitry.
The rectifier may contain one or more diodes.
In additional embodiments, the diode may be a Schottky diode, having instantaneous switching and negligible reverse recovery current. Schottky diodes are frequently used in RF detectors and mixers, allowing the use of small inductors and capacitors with greater efficiency.
Conditioning circuitry may include electronic components such as diodes, resistors and capacitors. Conditioning circuitry can use the incoming energy to provide waveforms to devices for stimulation of tissue, as well as help provide power, parameter settings and other signals to the device. The wireless power receiver may include a conditioning circuitry.
Conditioning circuitry is configured to rectify the waveform signal received by the implanted non-inductive antenna(s). Conditioning circuitry may also have charge balance microelectronics to prevent the corrosion of the contacts that are used for stimulation or for recording, and that are exposed to tissue. Conditioning circuitry may also contain a current limiter, which may limit a characteristic (for example, current or duration) of an electrical pulse to ensure that the charge per phase remains below a threshold level. To minimize reflection of the energy back from the exposed contacts into the circuitry, conditioning circuitry may further include isolation circuits to block high frequency signals.
In one embodiment, the implantable power receiver system, preferably, has an overall diameter that allows it to pass through the lumen of a standard 14 gauge needle, or smaller, such as a 16, 18, 20, or 22 gauge needle.
In other embodiments, the implantable power receiver system can be delivered into a subject's body through a needle, such as, for example, a spinal needle, no larger than gauge 18, or an endoscope, no larger than gauge 22. In still other embodiments, an outside diameter of the receiver is less than an inside diameter of a 14 gauge cannula or syringe.
In still other embodiments, the implantable power receiver can be configured within a larger housing with the sensor or circuit, or integrated with the device that the power receiver is configured to provide power to.
In yet additional embodiments, the implantable power receiver can be tethered by a wire to a body of a device that it is providing power to.
Various embodiments of a wireless implantable power receiver system have distinct advantages over traditional wired devices in regards to ease of insertion, cross-connections, small size, elimination of extension wires for transferring energy, allowing placement with minimal trauma, not requiring an implantable pulse generator (IPG), and long term effective therapy. In contrast to the present invention, larger implantable devices, such as IPG technology, may cause increased scar tissue as well as tissue reactions that may affect efficacy and safety. With the current technology, there is no longer a requirement for an IPG in order to administer a therapy.
In another embodiment, once in position, no further skin incisions or placement of extensions, receivers or implanted pulse generators are needed.
In one embodiment, the implantable power receiver may produce electrical currents capable of stimulating tissue, provide parameter settings to a device, or produce a DC voltage to power a device without a physical connection to an implantable pulse generator (IPG) or use of an inductive coil. This can be advantageous relative to designs that employ inductive coils to receive RF power through inductive coupling and then transfer the received power to a large IPG device for recharging, particularly since the large IPG device for recharging can be as large as 100 mm by 70 mm, taking up from 18 cc to over 50 cc of space in the body.
In another embodiment, the implantable power receiver may be physically integrated with a device for implantation into the body.
In another embodiment, the receiver may power one or more devices. In another embodiment, the device may include a plurality of electrodes, for example, up to 100 or more, powered by one or more receivers. In still another embodiment, the device body may hold a plurality of implantable power receivers, for example, up to 4 or more.
Various implementations also may have an associated lower overall cost compared to existing implantable devices due to the elimination of the implantable pulse generator, and this may lead to wider adoption of neural modulation therapy for patients, broader use of sensors and implanted monitors, as well as localized medication delivery mechanisms.
Devices may include stimulators, telemetry devices, sensors and body monitoring devices which monitor various physiological processes including, for example, blood pressure or other vital signs including heart rate, temperature and respiration. In other embodiments, such devices may monitor a physiological indicator such as a change of a chemical or biological molecule within an organ, tissue or the bloodstream and (optionally) may power a subsequent device to release a predefined amount of a chemical or biologic drug in response to a physiological indicator measurement.
In further embodiments, devices may include recording electrodes, glucose monitors, cochlear implant devices, cardiac devices for monitoring, pacing and defibrillation, devices for monitoring vital signs, deep brain stimulators, sensors placed externally on the body or underneath the skin, and power drug releasing or time release devices, as well as devices for recording action potentials.
In other embodiments, a wireless implantable power receiver includes one or more non-inductive antennas configured to receive radiated energy. The wireless implantable power receiver further includes electronic circuitry configured to convert the radiated energy received by the one or more non-inductive antennas into (i) a DC power supply to provide power to one or more devices; (ii) a signal to provide parameter settings to the device; (iii) a waveform to provide stimulatory signals to a tissue; or (iv) any combination thereof. The device is selected from the group consisting of: (a) a glucose monitor; (b) a cardiac device for monitoring, pacemaking or defibrillation; (c) one or more internal sensors for measuring vital signs; (d) one or more external sensors, such as EEG or ECG sensors, for measuring electrical activity; (e) microwires which measure action potential activity; (f) a time-release capsule or a drug-release device; (g) a cochlear lead; or (h) a deep brain stimulation device.
In another aspect, the implantable power receiver system includes a controller module. The controller module includes one or more non-inductive antenna(s) and one or more circuits. The non-inductive antenna(s) is configured to send a signal containing electrical energy to a remote antenna through electrical radiative coupling. The remote antenna, located externally to the implantable power receiver, is located in a module configured to create one or more electrical pulses suitable for parameter inputs to devices or to generate signals for tissue stimulation. The non-inductive antenna(s) is also configured to receive one or more signals from the remote antenna, extract a feedback signal from the one or more received signals, extract one or more parameters, and adjust an input signal to the device based upon the feedback signal. The one or more parameters of the electrical pulse may include an amplitude, duration or frequency of one or more electrical signals. In another embodiment, the receiver may provide parameter settings to a device which include frequency, amplitude and duration parameters. The implantable power receiver may provide power to the controller module.
In another aspect, the implantable power receiver communicates with one or more external devices, physically apart from the receiver, to facilitate a feedback mechanism for parameter control. For example, the implantable power receiver may also include one or more circuits for communicating information to a remote antenna of an external device, to facilitate a feedback control mechanism for parameter control. For example, the implanted power receiver may send to the second antenna a feedback signal that is indicative of the physical state of the biological process or device being monitored, and the external system may adjust parameters of the signal sent to the device through a feedback control signal.
In other embodiments, the wireless receiver system may record a physiological parameter, such as the electrical activity of the heart. In other embodiments, the wireless receiver system may contain electronic circuitry to transmit signals recorded by a device wirelessly for storage in a remote device or for processing.
In other embodiments, the wireless implantable power receiver system includes a remote system that processes signals transmitted by the receiver, to produce parameter signals, tissue stimulation signals, or both, which are transmitted to the implantable power receiver for distribution to one or more devices or tissue.
Additional embodiments of the present invention provide a method of providing power to an implanted device. The method includes providing an implantable wireless power receiver including an enclosure, and enclosure housing that houses a non-inductive antenna(s). The antenna is configured to receive, from a remote antenna and through electrical radiative coupling, an input signal containing electrical energy. The remote antenna is physically separate from the implantable receiver. One or more circuits are electrically connected to the non-inductive antenna(s) and are configured to convert the electrical energy contained in the input signal to a constant power source, preferably a DC power source. The enclosure is shaped and arranged for delivery into a subject's body through an introducer or needle.
Further embodiments of the invention provide a method of delivering electrical signals to power to the device, including enclosing the implantable wireless power receiver within the device, implanting the receiver and the device into tissue, and receiving and converting radiated energy into a DC power supply for distribution to the device, wherein the device excludes a connector.
In another embodiment, the invention may further include a method of providing parameters to a device, including receiving radiated energy by one or more non-inductive antennas and converting the radiated energy using electronic circuitry into a parameter input for distribution to the device, and delivering the parameter input to the device, wherein the device excludes a connector.
In still further embodiments, the invention further includes a method of providing stimulatory waveforms to tissue, including receiving radiated energy from one or more non-inductive antennas and converting the radiated energy using electronic circuitry into an electrical waveform suitable for tissue simulation, delivering the waveform to the device for distribution into the tissue, and stimulating the tissue, wherein the device excludes a connector.
Neural tissue associated with the spinal column includes the spinothalamic tracts, dorsal horn, dorsal root ganglia, dorsal roots, dorsal column fibers, and peripheral nerve bundles leaving the dorsal column or brainstem.
The wireless implantable power receiver system may (optionally) include electronic circuitry to transmit recorded signals from the device to which it provides power, to a remote system for storage, processing, or both. The remote system processes received signals to produce parameter signals, tissue stimulation signals, or any combination thereof, which are then transmitted to the implantable power receiver for distribution to one or more devices.
In
In some embodiments, the received signal by a supplemental antenna 200B can be processed by a communication block 250 which is connected to the controller 240. In other embodiments, the controller 240 can pass the received DC power to the communications block 250 for demodulation and passing back to the controller.
In addition to supplying the connected device with DC power, the controller 240 can generates a data signal, which may be based upon the received energy from the DC Power and/or from energy received at antenna 200. The DC power can be distributed to the medical device. In a further embodiment, in cases in which the receiver is connected to multiple devices or multiple tissue sites, the design configuration may contain a multiplexer 260 to deliver a designated signal to a specific device or tissue. The controller 240 may also supply a MUX control signal, to select a particular output channel of the multiplexer 260. Additionally, the output of the controller 240 can be transmitted to a remote site for storage or further processing.
In still another embodiment,
The various configurations shown in
In another embodiment, the implantable receiver 110 may be within a lead body connected to an electrode array that is placed into a descending branch of the left or right pulmonary artery (PA). The lead body with the implantable receiver 110 may be marked with a material to allow visualization, such as through fluoroscopy, during placement.
In addition to sensors, the implantable receiver 110 may be used to power circuitry which transmits measured information to an external device for processing and storage.
In another embodiment, the implantable receiver 110 is connected to leads, which are flexible, insulated wires implanted into the heart 440 to monitor the heart's electrical activity. For example, a typical procedure would involve placing one or more leads into the heart 440, such as the right atrium, the right ventricle, or both. In another embodiment, the leads may be placed on or in close proximity to the sinoatrial node.
In one embodiment, the implantable receiver system may monitor the electrical activity of the heart 440 through the implanted leads, and deliver electrical signals to the heart muscle, if the pace becomes too slow or too fast. In another embodiment, pacing and defibrillation may be performed in the right ventricle, in the right atrium, or both. In another embodiment, pacing may be performed on a time scale commensurate with the rate of beating of the heart 440.
In yet another embodiment, the implantable receiver system stores parameters for maintaining certain “pacing conditions.” The receiver 110 may also receive parameter signals for pacing or defibrillation.
This figure illustrates a receiver 110, shown as a hatched circle, connected to a sensor, such as an EEG pad 520, placed on the surface of a head. The receiver 110 provides power to the EEG sensor 520 as well as transmits recorded signals of the electrical activity of the brain to an external device for processing or display on a monitor.
In yet another embodiment, the receiver 110 may be connected to an ECG device to diagnose disorders such as cardiac arrhythmias. Such arrhythmias may result from abnormalities in electrical activity of the sinus node, from irregular beats in the chambers of the heart, abnormal electrical pathways in the heart or irregularities from underlying coronary artery disease. Such disorders may include, but are not limited to, for example, sinus arrhythmia, sinus tachycardia, sinus brachycardia, sick sinus syndrome, premature atrial contraction, supraventricular tachycardia, Wolfe-Parkinson-White syndrome, atrial flutter and atrial fibrillation, premature ventricular complexes, ventricular tachycardia and ventricular fibrillation.
In one embodiment, the microwires 630 can be made from materials comprised of metal, conducting polymers, or other materials with conductive properties.
In another embodiment, the microwires 630 may be implanted for continuous recording of electrophysiological activity. The receiver 110, in this case, may also transmit the recorded signal to an external device for storage and processing.
In another embodiment, the receiver 110 may be implanted under the skin to power another component, to control drug release from implanted time-release capsules or a drug pump unit.
A drug pump unit 910 may contain a pump (round device) for storing and delivering medication as well as a catheter 930, or thin, flexible tubing, for delivering medication to a particular location. The drug pump unit may release the drug via (i) a nonprogrammable fixed-rate method in which the dose may be changed by adjusting the concentration of the drug or (2) a programmable method in which a single or a timed dose may be administered, or the infusion rate may be adjusted.
The receiver 110 may provide power, parameters to the drug pump unit to control the amount of and rate of release of the medication.
In another embodiment, a microchip with one or more reservoirs is implanted into tissue. The reservoirs are storage units for pharmaceuticals. The receiver 110 may receive radiated energy and convert this into a power supply and parameter settings for triggering the opening of a particular reservoir chamber for distribution of drugs.
The receiver 110 may provide power and stimulatory signals to the cochlear lead 1010. The cochlear lead 1010 has a plurality of electrodes 1030 which may be configured to stimulate an auditory nerve from within a cochlea.
Cochlear systems may have an externally located transmitter that transmits sound information to the internally located position of the device, a cochlear lead 1010, a microphone to capture sound information in the environment, and a signal processing unit to convert the sound to a signal to be transmitted to the cochlear lead 1010.
In one embodiment of the present invention, the cochlear lead 1010 has an implantable power receiver 110 that receives the power and converts this into an electrical signal to power the electronics of the cochlear system. The power receiver 110 also converts the received signal by the non-inductive antenna(s) to a digital data set instruction.
In other embodiments, the present invention may improve the form factor of the implanted cochlear lead 1010.
Deep brain stimulation (DBS) systems may include a lead, with one or more electrodes, a neurostimulator (for example, an IPG) with microelectronics and a power supply. The lead is placed within the brain.
DBS may be useful for various movement disorders, including but not limited to, for example, Parkinson's disease, essential tremor, arm tremors and dystonia. Additionally, DBS systems can be used to treat a variety of neurological conditions, including but not limited to, for example, Tourette syndrome, obsessive-compulsive disorder, and major depression.
Pulses of electrical energy can be used to interfere with and block electrical signals that cause movement disorders.
Unless otherwise indicated, all numbers expressing quantities of ingredients, properties such as molecular weight, reaction conditions, and so forth used in the specification and claims are to be understood as being modified in all instances by the term “about.” Accordingly, unless indicated to the contrary, the numerical parameters set forth in the specification and attached claims are approximations that may vary depending upon the desired properties sought to be obtained by the present invention. At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.
The terms “a,” “an,” “the” and similar referents used in the context of describing the invention (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. Recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., “such as”) provided herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.
Groupings of alternative elements or embodiments of the invention disclosed herein are not to be construed as limitations. Each group member may be referred to and claimed individually or in any combination with other members of the group or other elements found herein. It is anticipated that one or more members of a group may be included in, or deleted from, a group for reasons of convenience and/or patentability. When any such inclusion or deletion occurs, the specification is deemed to contain the group as modified thus fulfilling the written description of all Markush groups used in the appended claims.
Certain embodiments of this invention are described herein, including the best mode known to the inventors for carrying out the invention. Of course, variations on these described embodiments will become apparent to those of ordinary skill in the art upon reading the foregoing description. The inventors expect skilled artisans to employ such variations as appropriate, and the inventors intend for the invention to be practiced otherwise than specifically described herein. Accordingly, this invention includes all modifications and equivalents of the subject matter recited in the claims appended hereto as permitted by applicable law. Moreover, any combination of the above described elements in all possible variations thereof is encompassed by the invention unless otherwise indicated herein or otherwise clearly contradicted by context.
Specific embodiments disclosed herein may be further limited in the claims using consisting of or consisting essentially of language. When used in the claims, whether as filed or added per amendment, the transition term “consisting of” excludes any element, step, or ingredient not specified in the claims. The transition term “consisting essentially of” limits the scope of a claim to the specified materials or steps and those that do not materially affect the basic and novel characteristic(s). Embodiments of the invention so claimed are inherently or expressly described and enabled herein.
This application claims the benefit of and priority to U.S. Provisional Patent Application No. 61/786,069, which was filed on Mar. 14, 2013. The foregoing U.S. provisional application is incorporated by reference herein in its entirety.
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