The present disclosure relates to bandages for wounds, and in some instances, to bandages for use with a vacuum and/or irrigation source. Specifically, the present disclosure relates to wound packing used with vacuum bandages or other types of bandages to keep a wound from closing in an unwanted manner.
The prior art contemplates that chronic wounds may be treated by providing a vacuum in the space above the wound to promote healing. A number of prior art references teach the value of the vacuum bandage or the provision of vacuum in the space above the surface of a chronic wound.
A vacuum bandage is a bandage having a cover for sealing about the outer perimeter of the wound and under which a vacuum is established to act on the wound surface. Applying vacuum to the wound surface promotes healing of chronic wounds. Typically, suction tubes are provided for drawing exudate away from the wound and for creating a vacuum under the cover. The following U.S. patents establish the nature of vacuum treatment bandages and devices: U.S. Pat. Nos. 6,095,992, 6,080,189, 6,071,304, 5,645,081, 5,636,643, 5,358,494, 5,298,015, 4,969,880, 4,655,754, 4,569,674, 4,382,441, and 4,112,947. All of such references are incorporated herein by reference.
Further, the prior art contemplates that wounds may be treated by providing irrigation in the space above the wound. Typically, a tube is provided in communication with the wound surface of the wound at one end and with an irrigation source an another end. The fluid from the irrigation source travels through the tube to the wound surface.
Additionally, it is desirable to keep wound surfaces separated in some types of wounds. For example, after sinus surgery, certain wound surfaces should be separated to prevent closure of the wound in an unwanted manner.
The present invention comprises one or more of the following features, discussed below, or any combination thereof.
According to the present disclosure, several embodiments of wound packing for preventing wound closure in an unwanted manner are provided. In some embodiments, a vacuum bandage system is provided for use with a wound having a wound surface. The vacuum bandage system may include a wound dressing member and a wound insert. The wound dressing member may include a plurality of holes and a port in communication with the holes. The port may also be configured to be coupled to a vacuum source. The wound insert may be configured for placement within the wound between the wound surface and the wound dressing member. The wound insert may be made of a material which is not porous or foam-like.
The wound insert may be thin and flexible and may include a plurality of discrete passageways. The passageways may be in communication with the vacuum source. The passageways of the wound insert may be conduits through the wound insert or the passageways may comprise channels formed in each of a top and bottom surface of the insert.
In an illustrative embodiment, the insert is cylindrical in shape and is made of approximately 50 durometer silicone. Such an insert may have a diameter of approximately 0.0925 inch (2.35 mm).
Further according to the present disclosure, a method of treating a wound having a wound tunnel is provided. The method may include placing a non-porous wound insert within a tunneled portion of a wound and placing a wound dressing member over the wound insert so that the wound insert is positioned between a wound surface of the wound and the wound dressing member. The method further may include coupling the wound dressing member to a vacuum source, placing a sealing film over the wound dressing member for attachment to healthy skin surrounding the wound, and creating a negative pressure between the sealing film and a surface of the wound.
The wound inserts or packing disclosed herein may be used with all types of wounds and bandages. Thus, such wound packing may be used with regular bandages and/or vacuum bandages and/or irrigation bandages.
Features of the present invention will become apparent to those skilled in the art upon consideration of the following detailed description of the preferred embodiments exemplifying the best mode of carrying out the invention as presently perceived.
The detailed description particularly refers to the accompanying figures in which:
A wound care bandage system 10 is provided for use with a wound 12, and specifically for use with a wound tunnel 14 of wound 12 (as shown in
In some uses, wound inserts are provided to generally fill the open space created by various wound tunnels 14 and/or undermined portions 16 of wounds 12. Such wound tunnels 14 and undermined portions 16 are generally ulcerated portions of wound 12. Wound inserts help to maintain the opening created by the wound tunnels 14 and/or undermined portions 16 until the wound 12 can properly heal on its own. Further, wound inserts force the wound openings to heal generally evenly so that side and bottom surfaces 15 of wound tunnels 14 and side to bottom surfaces 17 of undermined portions 16 gradually heal toward each other to progressively shrink the open space. This may also help to prevent a “bridge” of granulations from forming across the open space and effectively sealing off an ulcerated portion of the of wound 12, thus preventing the sealed-off area from being able to be treated by the vacuum and/or irrigation of system 10.
Vacuum bandage 18, as shown in
System 10 promotes the healing of the wound 12 by providing vacuum therapy to the wound to promote blood flow and remove exudate from the wound surfaces 15, 17 of illustrative wound tunnel 14 and undermined portions 16 and by providing for irrigation of the wound 12 with fluids such as saline, for example. An illustrative wound treatment apparatus having a wound temperature control system, a medicine delivery system, and a drainage system is disclosed in U.S. Pat. No. 6,458,109. An illustrative vacuum and irrigation system is disclosed in U.S. patent Publication No. US 2002/0161317 A1. Additionally, an illustrative vacuum bandage is disclosed in U.S. patent Publication No. US 2002/0065494 A1.
Alternative vacuum bandages are disclosed in U.S. Patent Publication No. US 2002/0082567 A1. Further, a vacuum bandage system including a controller of the system is disclosed in U.S. application Ser. No. 10/159,583, filed on May 31, 2002, titled WOUND TREATMENT APPARATUS and in U.S. Application No. 60/394,970 filed on May 31, 2002, titled WOUND TREATMENT APPARATUS. All of the applications mentioned in this and the preceding paragraph are hereby incorporated herein by reference.
As shown in
Further, insert 26 may be molded to include anti-microbial constituents. For example, it is within the scope of this disclosure to impregnate insert 26 with silver ions which are known anti-microbials. The following PCT publications illustrate the use of anti-microbials in various products and are incorporated herein by reference: “Antimicrobial Plastic Closures for Drinking Containers”, WO 00/26100; “Antimicrobial Contact Lens Case”, WO 00/038552; “Antimicrobial Fabric and Medical Graft of the Fabric”, WO 00/32247; “Antimicrobial Suturing Ring for Heart Valve”, WO 00/30567.
Insert 26 is also made of a generally non-adhesive material. Therefore, portions of insert 26 which may abut wound surfaces 15, 17 of wound tunnel 14 and/or undermined portions 16 of wound 12 do not adhere to the wound surfaces 15, 17. Further, insert 26 is solid in nature and generally non-compressible. For example, when a negative pressure is applied to insert 26, a thickness of insert 26 remains relatively constant.
As shown in
Length 40 of illustrative insert 26 may be up to about 30 mm and width 42 of insert 26 may also be up to about 30 mm. Further, a thickness 43 of insert 26 may be within the range of about 1 mm to about 15 mm, for example. Although illustrative insert 26 has the above-mentioned dimensions, it is within the scope of this disclosure for insert 26 (an similar alternative inserts described below) to have other suitable dimensions for treating wounds and particularly for treating tunneled and/or undermined portions of wounds in a vacuum therapy system. Further, although insert 26 may be formed having certain dimensions, it is within the scope of this disclosure for a caregiver to trim insert 26 to fit a particular wound.
Another illustrative insert 126 is shown in
As mentioned above, another illustrative insert 226 is provided in
As shown in
Still another alternative insert 526 is shown in
Looking now to
Another illustrative wound insert 726 is shown in
As is described above, various illustrative wound inserts 26, 126, 226, 326, 426, 526, 626, 726 are provided for use with a vacuum bandage or with other types of bandages or alone (i.e., without other bandage components). Illustrative inserts are all thin and flexible and generally rectangularly shaped, although, it is within the scope of this disclosure to include thin, flexible inserts of any suitable shape such as circular, triangular, oval, etc. In addition, a caregiver may trim any of the disclosed inserts to a desired shape using scissors, for example. Further, all inserts described above include passageways such as conduits 38, through holes 138, and/or channels 438. In some embodiments, the passageways are provided to communicate negative pressure from vacuum source 20, or fluid from irrigation source 22, to tunneled portions 14 or undermined portions 16 of wound 12.
Yet another illustrative insert 826 is shown in
Still another insert 926 is shown in
Inserts 926 may be extruded to any suitable length. Further, a caregiver dressing a particular tunneled wound 14 may further trim inserts 926 to an appropriate length. Inserts 926 are made from the same material described above with respect to the other inserts of the present disclosure. Each insert 926 includes a cylindrical body 929, a first end 930, and a second end 932 (shown in
As mentioned above, wound inserts 26, 126, 226, 326, 426, 526, 626, 727, 826, 926 are provided for placement within a wound tunnel 14 and/or an undermined portion 16 of a wound 12, such as that illustrated in
Generally, prior to insertion within a wound tunnel 14, for example, the thin, flat inserts 26, 126, 226, 326, 426, 526, 626, 726 are rolled along their length 40.
It is also contemplated that, in some embodiments, illustrative inserts are in communication with vacuum source 20 through vacuum bandage 18 and therefore may communicate the suction or negative pressure from vacuum source 20 along the passageways of each insert to the bottom and side walls 15 of tunnel 14. This negative pressure may help draw exudate away from wound 12. The vacuum or negative pressure which draws blood from the body to the wound surface 15 and draws exudate from the wound 12 up through the respective insert and through portions of vacuum bandage 18 promotes the healing of wound 12. As wound 12 heals, granulations form along wound surface 15. Granulations, therefore, are the replacement within the wound bed of tissue lost.
As shown in
Illustratively, it is not necessary for a caregiver to roll insert 826 (shown in
In the treatment of undermined portions 16 of wounds 12, it may not be necessary to roll an insert into a tube-like shape as is described above with respect to tunneled portions 14 of wounds 12. As is illustratively shown in
As mentioned above, wound inserts of the present disclosure may be provided as part of vacuum bandage system 10 for use with a vacuum bandage 18 coupled to vacuum source 20. Bandage 18 may also be coupled to irrigation source 22, as shown in
Illustrative member 52 of bandage 18 includes a smooth wound facing surface 54. Wound facing surface 54 may also be textured or roughened and/or may include spacers, ribs, protrusions, etc., extending from surface 54. Member 52 further includes opposite surface 56. Illustrative member 50 further includes a tube connector or port 58 coupled to opposite surface 56. Connector 58 is coupled to a tube 60 of system 10 in communication with vacuum and irrigation sources 20, 22. Member 50 also includes one or more passageways 62 formed between opposite surface 56 and wound facing surface 54. Each passageway 62 is in communication with connector 58 to communicate either negative pressure from vacuum source 20 to wound 12 or to communicate fluid from irrigation source 22 to wound 12. A plurality of holes 64 are illustratively provided through wound facing surface 54. Holes 64 communicate with wound 12 and passageways 62 as well. Further illustratively, wound member 52 is made of the same material as the various wound inserts described above. Although illustrative member 52 is provided, it is within the scope of this disclosure to include a vacuum bandage having any suitable type of wound dressing member having means for communicating negative pressure and/or irrigation fluid to the wound.
Although the invention has been described in detail with reference to certain embodiments, variations to modifications exist within the scope and spirit of the invention as described and defined in the following claims.
This application is a U.S. national counterpart application of international application serial no. PCT/US2002/041234 filed Dec. 20, 2002, which claims the benefit of U.S. provisional application Ser. No. 60/405,010 filed Aug. 21, 2002.
Filing Document | Filing Date | Country | Kind | 371c Date |
---|---|---|---|---|
PCT/US02/41234 | 12/20/2002 | WO | 00 | 2/18/2005 |
Publishing Document | Publishing Date | Country | Kind |
---|---|---|---|
WO2004/018020 | 3/4/2004 | WO | A |
Number | Name | Date | Kind |
---|---|---|---|
774529 | Nieschang | Nov 1904 | A |
1000001 | Holz | Aug 1911 | A |
1355846 | Rannells | Oct 1920 | A |
1385346 | Taylor | Jul 1921 | A |
1709520 | Chandler | Apr 1929 | A |
1936129 | Fisk | Nov 1933 | A |
2078180 | Kronenberg | Apr 1937 | A |
2195771 | Estler | Apr 1940 | A |
2221758 | Elmquist | Nov 1940 | A |
2305289 | Coburg | Dec 1942 | A |
2338339 | LaMere et al. | Jan 1944 | A |
2443481 | Sene | Jun 1948 | A |
2547758 | Keeling | Apr 1951 | A |
2560915 | Bamberger | Jul 1951 | A |
2573791 | Howells | Nov 1951 | A |
2577945 | Atherton | Dec 1951 | A |
2632443 | Lesher | Mar 1953 | A |
2682873 | Evans et al. | Jul 1954 | A |
2910763 | Lauterbach | Nov 1959 | A |
2969057 | Simmons | Jan 1961 | A |
3026874 | Stevens | Mar 1962 | A |
3066672 | Crosby, Jr. et al. | Dec 1962 | A |
3315665 | MacLeod | Apr 1967 | A |
3367332 | Groves | Feb 1968 | A |
3382867 | Reaves | May 1968 | A |
3430631 | Abramson | Mar 1969 | A |
3492991 | Dyer, Jr. | Feb 1970 | A |
3520300 | Flower, Jr. | Jul 1970 | A |
3528416 | Chamberlain | Sep 1970 | A |
3568675 | Harvey | Mar 1971 | A |
3585742 | Tyler | Jun 1971 | A |
3599639 | Spotz | Aug 1971 | A |
3610238 | Rich, Jr. | Oct 1971 | A |
3623087 | Gallichotte | Nov 1971 | A |
3648692 | Wheeler | Mar 1972 | A |
3682180 | McFarlane | Aug 1972 | A |
3683894 | Villari | Aug 1972 | A |
3721244 | Elmaleh | Mar 1973 | A |
3752158 | Kariher | Aug 1973 | A |
3753439 | Brugarolas et al. | Aug 1973 | A |
3782377 | Rychlik | Jan 1974 | A |
3812972 | Rosenblum | May 1974 | A |
3814095 | Lubens | Jun 1974 | A |
3823720 | Tribble | Jul 1974 | A |
3826254 | Mellor | Jul 1974 | A |
3831588 | Rindner | Aug 1974 | A |
3860008 | Miner et al. | Jan 1975 | A |
3874387 | Barbieri | Apr 1975 | A |
3903882 | Augurt | Sep 1975 | A |
3924624 | Schachet | Dec 1975 | A |
3935863 | Kliger | Feb 1976 | A |
3954105 | Nordby et al. | May 1976 | A |
3982546 | Friend | Sep 1976 | A |
4004590 | Muriot | Jan 1977 | A |
4013076 | Puderbaugh et al. | Mar 1977 | A |
RE29319 | Nordby et al. | Jul 1977 | E |
RE29321 | Holbrook | Jul 1977 | E |
4058123 | May | Nov 1977 | A |
4080970 | Miller | Mar 1978 | A |
4096853 | Weigand | Jun 1978 | A |
4112947 | Nehring | Sep 1978 | A |
4139004 | Gonzalez, Jr. | Feb 1979 | A |
4149541 | Gammons et al. | Apr 1979 | A |
4165748 | Johnson | Aug 1979 | A |
4178974 | Levin | Dec 1979 | A |
4184510 | Murry et al. | Jan 1980 | A |
4191204 | Nehring | Mar 1980 | A |
4219021 | Fink | Aug 1980 | A |
4224941 | Stivala | Sep 1980 | A |
4233969 | Lock et al. | Nov 1980 | A |
4245630 | Lloyd et al. | Jan 1981 | A |
4250882 | Adair | Feb 1981 | A |
4256109 | Nichols | Mar 1981 | A |
4261363 | Russo | Apr 1981 | A |
4275721 | Olson | Jun 1981 | A |
4284079 | Adair | Aug 1981 | A |
4297995 | Golub | Nov 1981 | A |
4333468 | Geist | Jun 1982 | A |
4341209 | Schaar | Jul 1982 | A |
4364394 | Wilkinson | Dec 1982 | A |
4373519 | Errede et al. | Feb 1983 | A |
4382441 | Svedman | May 1983 | A |
4392853 | Muto | Jul 1983 | A |
4392858 | George et al. | Jul 1983 | A |
4399816 | Spangler | Aug 1983 | A |
4419097 | Rowland | Dec 1983 | A |
4445897 | Ekbladh et al. | May 1984 | A |
4457755 | Wilson | Jul 1984 | A |
4460370 | Allison et al. | Jul 1984 | A |
4465062 | Versaggi et al. | Aug 1984 | A |
4465485 | Kashmer et al. | Aug 1984 | A |
4469092 | Marshall et al. | Sep 1984 | A |
4475909 | Eisenberg | Oct 1984 | A |
4480638 | Schmid | Nov 1984 | A |
4508533 | Abramson | Apr 1985 | A |
4525156 | Benusa et al. | Jun 1985 | A |
4525166 | Leclerc | Jun 1985 | A |
4525374 | Vaillancourt | Jun 1985 | A |
4533352 | Van Beek et al. | Aug 1985 | A |
4533419 | Pieslak et al. | Aug 1985 | A |
4540412 | Van Overloop | Sep 1985 | A |
4543100 | Brodsky | Sep 1985 | A |
4548202 | Duncan | Oct 1985 | A |
4551139 | Plaas et al. | Nov 1985 | A |
4553967 | Ferguson et al. | Nov 1985 | A |
4569348 | Hasslinger | Feb 1986 | A |
4569674 | Phillips et al. | Feb 1986 | A |
4573965 | Russo | Mar 1986 | A |
4579555 | Russo | Apr 1986 | A |
4596564 | Spetzler et al. | Jun 1986 | A |
4605399 | Weston et al. | Aug 1986 | A |
4608041 | Nielsen | Aug 1986 | A |
4614794 | Easton et al. | Sep 1986 | A |
4624656 | Clark et al. | Nov 1986 | A |
4633863 | Filips et al. | Jan 1987 | A |
4637819 | Ouellette et al. | Jan 1987 | A |
4640688 | Hauser | Feb 1987 | A |
4641643 | Greer | Feb 1987 | A |
4645492 | Weeks | Feb 1987 | A |
4655210 | Edenbaum et al. | Apr 1987 | A |
4655754 | Richmond et al. | Apr 1987 | A |
4661093 | Beck et al. | Apr 1987 | A |
4664652 | Weilbacher | May 1987 | A |
4664662 | Webster | May 1987 | A |
4667666 | Fryslie | May 1987 | A |
4679590 | Hergenroeder | Jul 1987 | A |
4704102 | Guthery | Nov 1987 | A |
4710165 | McNeil et al. | Dec 1987 | A |
4713051 | Steppe et al. | Dec 1987 | A |
4717332 | Edens | Jan 1988 | A |
4717379 | Ekholmer | Jan 1988 | A |
4717382 | Clemens et al. | Jan 1988 | A |
4733659 | Edenbaum et al. | Mar 1988 | A |
4735606 | Davison | Apr 1988 | A |
4735610 | Akkas et al. | Apr 1988 | A |
4740202 | Stacey et al. | Apr 1988 | A |
4743232 | Kruger | May 1988 | A |
4747166 | Kuntz | May 1988 | A |
4758220 | Sundblom et al. | Jul 1988 | A |
4759354 | Quarfoot | Jul 1988 | A |
4765316 | Marshall | Aug 1988 | A |
4778446 | Jensen | Oct 1988 | A |
4778456 | Lokken | Oct 1988 | A |
4787888 | Fox | Nov 1988 | A |
4798578 | Ranford | Jan 1989 | A |
4820265 | DeSatnick et al. | Apr 1989 | A |
4820284 | Hauri | Apr 1989 | A |
4826494 | Richmond et al. | May 1989 | A |
4826949 | Stanko | May 1989 | A |
4834110 | Richard | May 1989 | A |
4838883 | Matsuura | Jun 1989 | A |
4840187 | Brazier | Jun 1989 | A |
4841962 | Berg et al. | Jun 1989 | A |
4850350 | Jackson | Jul 1989 | A |
4863449 | Therriault et al. | Sep 1989 | A |
4872450 | Austad | Oct 1989 | A |
4878901 | Sachse | Nov 1989 | A |
4890608 | Steer | Jan 1990 | A |
4897081 | Poirier et al. | Jan 1990 | A |
4900302 | Newton | Feb 1990 | A |
4902508 | Badylak et al. | Feb 1990 | A |
4906233 | Moriuchi et al. | Mar 1990 | A |
4906240 | Reed et al. | Mar 1990 | A |
4915694 | Yamamoto et al. | Apr 1990 | A |
4917112 | Kalt | Apr 1990 | A |
4919654 | Kalt | Apr 1990 | A |
4921492 | Schultz et al. | May 1990 | A |
4930997 | Bennett | Jun 1990 | A |
4941882 | Ward et al. | Jul 1990 | A |
4950230 | Kendell | Aug 1990 | A |
4953565 | Tachibana et al. | Sep 1990 | A |
4956178 | Badylak et al. | Sep 1990 | A |
4957492 | McVay | Sep 1990 | A |
4962761 | Golden | Oct 1990 | A |
4969880 | Zamierowski | Nov 1990 | A |
4969881 | Viesturs | Nov 1990 | A |
4970298 | Silver et al. | Nov 1990 | A |
4985019 | Michelson | Jan 1991 | A |
4988336 | Kohn | Jan 1991 | A |
4990144 | Blott | Feb 1991 | A |
4991574 | Pocknell | Feb 1991 | A |
4994022 | Steffler et al. | Feb 1991 | A |
4997425 | Shioya et al. | Mar 1991 | A |
5000172 | Ward | Mar 1991 | A |
5000741 | Kalt | Mar 1991 | A |
5002528 | Palestrant | Mar 1991 | A |
5002529 | Cunningham | Mar 1991 | A |
5003971 | Buckley | Apr 1991 | A |
5014389 | Ogilvie et al. | May 1991 | A |
5034003 | Denance | Jul 1991 | A |
5034006 | Hosoda et al. | Jul 1991 | A |
5035865 | Inaba et al. | Jul 1991 | A |
5037397 | Kalt et al. | Aug 1991 | A |
5042978 | Quenin et al. | Aug 1991 | A |
5045777 | Itagaki | Sep 1991 | A |
5060662 | Farnswoth, III | Oct 1991 | A |
5071409 | Rosenberg | Dec 1991 | A |
5073172 | Fell | Dec 1991 | A |
5080650 | Hirsch et al. | Jan 1992 | A |
5086170 | Luheshi et al. | Feb 1992 | A |
5086763 | Hathman | Feb 1992 | A |
5086764 | Gilman | Feb 1992 | A |
5092858 | Benson et al. | Mar 1992 | A |
5100395 | Rosenberg | Mar 1992 | A |
5100396 | Zamierowski | Mar 1992 | A |
5101808 | Kobayashi et al. | Apr 1992 | A |
5106362 | Gilman | Apr 1992 | A |
5106629 | Cartmell et al. | Apr 1992 | A |
5108364 | Takezawa et al. | Apr 1992 | A |
5134994 | Say | Aug 1992 | A |
5135518 | Vera | Aug 1992 | A |
5146925 | Snow | Sep 1992 | A |
5147338 | Lang et al. | Sep 1992 | A |
5149331 | Ferdman et al. | Sep 1992 | A |
5152757 | Eriksson | Oct 1992 | A |
5160322 | Scheremet et al. | Nov 1992 | A |
5167613 | Karami et al. | Dec 1992 | A |
5167622 | Muto | Dec 1992 | A |
5170781 | Loomis | Dec 1992 | A |
5176502 | Sanderson et al. | Jan 1993 | A |
5176663 | Svedman et al. | Jan 1993 | A |
5176667 | DeBring | Jan 1993 | A |
5181908 | Bell | Jan 1993 | A |
5189609 | Tivig et al. | Feb 1993 | A |
5197948 | Ghodsian | Mar 1993 | A |
5215522 | Page et al. | Jun 1993 | A |
5215539 | Schoolman | Jun 1993 | A |
5224929 | Remiszewski | Jul 1993 | A |
5228431 | Giarretto | Jul 1993 | A |
5230350 | Fentress | Jul 1993 | A |
5232453 | Plass et al. | Aug 1993 | A |
5238654 | Nohl et al. | Aug 1993 | A |
5249121 | Baum et al. | Sep 1993 | A |
5256418 | Kemp et al. | Oct 1993 | A |
5261893 | Zamierowski | Nov 1993 | A |
5263922 | Sova et al. | Nov 1993 | A |
5265605 | Afflerbach | Nov 1993 | A |
5275826 | Badylak et al. | Jan 1994 | A |
5278100 | Doan et al. | Jan 1994 | A |
5279550 | Habib et al. | Jan 1994 | A |
5281422 | Badylak et al. | Jan 1994 | A |
5291887 | Stanley et al. | Mar 1994 | A |
5298015 | Komatsuzaki et al. | Mar 1994 | A |
5306298 | Godley, III et al. | Apr 1994 | A |
5314409 | Sarosiek et al. | May 1994 | A |
5330452 | Zook | Jul 1994 | A |
5335651 | Foster et al. | Aug 1994 | A |
5338293 | Jeppsson et al. | Aug 1994 | A |
5342293 | Zanger | Aug 1994 | A |
5342301 | Saab | Aug 1994 | A |
5342376 | Ruff | Aug 1994 | A |
5344415 | DeBusk et al. | Sep 1994 | A |
5349965 | McCarver | Sep 1994 | A |
5352463 | Badylak et al. | Oct 1994 | A |
5358494 | Svedman | Oct 1994 | A |
5370610 | Reynolds | Dec 1994 | A |
5372821 | Badylak et al. | Dec 1994 | A |
5374254 | Buma | Dec 1994 | A |
5376252 | Ekstrom et al. | Dec 1994 | A |
5380280 | Peterson | Jan 1995 | A |
5395315 | Griep | Mar 1995 | A |
5409013 | Clement | Apr 1995 | A |
5413788 | Edwards et al. | May 1995 | A |
5419768 | Kayser | May 1995 | A |
5431622 | Pyrozyk et al. | Jul 1995 | A |
5437622 | Carion | Aug 1995 | A |
5437651 | Todd et al. | Aug 1995 | A |
5445604 | Lang | Aug 1995 | A |
5445833 | Badylak et al. | Aug 1995 | A |
5447505 | Valentine et al. | Sep 1995 | A |
5449383 | Chatelier et al. | Sep 1995 | A |
5451215 | Wolter | Sep 1995 | A |
5451373 | Lewis et al. | Sep 1995 | A |
5478333 | Asherman, Jr. | Dec 1995 | A |
5484420 | Russo | Jan 1996 | A |
5484427 | Gibbons | Jan 1996 | A |
5484428 | Drainville et al. | Jan 1996 | A |
5487889 | Eckert et al. | Jan 1996 | A |
5516533 | Badylak et al. | May 1996 | A |
5520652 | Peterson | May 1996 | A |
5527293 | Zamierowski | Jun 1996 | A |
5531670 | Westby et al. | Jul 1996 | A |
5533981 | Mandro et al. | Jul 1996 | A |
5534346 | Robinson | Jul 1996 | A |
5540668 | Wilson, Jr. et al. | Jul 1996 | A |
5542918 | Atkinson | Aug 1996 | A |
5549584 | Gross | Aug 1996 | A |
5554389 | Badylak et al. | Sep 1996 | A |
5556375 | Ewall | Sep 1996 | A |
5558639 | Gangemi et al. | Sep 1996 | A |
5573784 | Badylak et al. | Nov 1996 | A |
5578022 | Scherson et al. | Nov 1996 | A |
5578662 | Bennett et al. | Nov 1996 | A |
5607388 | Ewall | Mar 1997 | A |
5621035 | Lyles et al. | Apr 1997 | A |
5624418 | Shepard | Apr 1997 | A |
5628735 | Skow | May 1997 | A |
5629186 | Yasukawa et al. | May 1997 | A |
5631011 | Wadström | May 1997 | A |
5635201 | Fabo | Jun 1997 | A |
5636643 | Argenta et al. | Jun 1997 | A |
5641518 | Badylak et al. | Jun 1997 | A |
5645081 | Argenta et al. | Jul 1997 | A |
5645860 | Knapp et al. | Jul 1997 | A |
5655258 | Heintz | Aug 1997 | A |
5656027 | Ellingboe | Aug 1997 | A |
5662598 | Tobin | Sep 1997 | A |
5662624 | Sundstrom et al. | Sep 1997 | A |
5662625 | Westwood | Sep 1997 | A |
5669892 | Keogh et al. | Sep 1997 | A |
5672151 | Calderon-Garciduenas | Sep 1997 | A |
5672152 | Mason et al. | Sep 1997 | A |
5674193 | Hayes | Oct 1997 | A |
5678564 | Lawrence et al. | Oct 1997 | A |
5681290 | Alexander | Oct 1997 | A |
5690815 | Krasnoff et al. | Nov 1997 | A |
5695998 | Badylak et al. | Dec 1997 | A |
5697920 | Gibbons | Dec 1997 | A |
5711969 | Patel et al. | Jan 1998 | A |
5718955 | McGuire et al. | Feb 1998 | A |
5735833 | Olson | Apr 1998 | A |
5741237 | Walker | Apr 1998 | A |
5749842 | Cheong et al. | May 1998 | A |
5753267 | Badylak et al. | May 1998 | A |
5755791 | Whitson et al. | May 1998 | A |
5759570 | Arnold | Jun 1998 | A |
5762640 | Kajiwara et al. | Jun 1998 | A |
5762966 | Knapp et al. | Jun 1998 | A |
5780281 | Yasukawa et al. | Jul 1998 | A |
5782871 | Fujiwara et al. | Jul 1998 | A |
5795584 | Totakura et al. | Aug 1998 | A |
5800383 | Chandler et al. | Sep 1998 | A |
5817145 | Augustine et al. | Oct 1998 | A |
5827246 | Bowen | Oct 1998 | A |
5827296 | Morris et al. | Oct 1998 | A |
5855619 | Caplan et al. | Jan 1999 | A |
5866414 | Badylak et al. | Feb 1999 | A |
5881723 | Wallace et al. | Mar 1999 | A |
5891111 | Ismael | Apr 1999 | A |
5902874 | Roby et al. | May 1999 | A |
5902875 | Roby et al. | May 1999 | A |
5911222 | Lawrence et al. | Jun 1999 | A |
5914387 | Roby et al. | Jun 1999 | A |
5919476 | Fischer et al. | Jul 1999 | A |
5921972 | Skow | Jul 1999 | A |
5928174 | Gibbins | Jul 1999 | A |
5931304 | Hammond | Aug 1999 | A |
5941859 | Lerman | Aug 1999 | A |
5942496 | Bonadio et al. | Aug 1999 | A |
5947914 | Augustine | Sep 1999 | A |
5951295 | Lyles et al. | Sep 1999 | A |
5954680 | Augustine | Sep 1999 | A |
5961480 | Augustine | Oct 1999 | A |
5962427 | Goldstein et al. | Oct 1999 | A |
5964721 | Augustine | Oct 1999 | A |
5964723 | Augustine | Oct 1999 | A |
5986163 | Augustine | Nov 1999 | A |
5997568 | Liu | Dec 1999 | A |
6010527 | Augustine et al. | Jan 2000 | A |
6013048 | Podany et al. | Jan 2000 | A |
6017493 | Cambron et al. | Jan 2000 | A |
6039724 | Seifert et al. | Mar 2000 | A |
6045518 | Augustine | Apr 2000 | A |
6045541 | Matsumoto et al. | Apr 2000 | A |
6051747 | Lindquist et al. | Apr 2000 | A |
6056730 | Greter | May 2000 | A |
6071254 | Augustine | Jun 2000 | A |
6071267 | Zamierowski | Jun 2000 | A |
6071304 | Augustine et al. | Jun 2000 | A |
6080189 | Augustine et al. | Jun 2000 | A |
6080243 | Insley et al. | Jun 2000 | A |
6093160 | Augustine et al. | Jul 2000 | A |
6093230 | Johnson, III et al. | Jul 2000 | A |
6095992 | Augustine | Aug 2000 | A |
6099567 | Badylak et al. | Aug 2000 | A |
6110197 | Augustine et al. | Aug 2000 | A |
6113561 | Augustine | Sep 2000 | A |
6117111 | Fleischmann | Sep 2000 | A |
6135116 | Vogel et al. | Oct 2000 | A |
6142982 | Hunt et al. | Nov 2000 | A |
6143945 | Augustine et al. | Nov 2000 | A |
6149614 | Dunshee et al. | Nov 2000 | A |
6171344 | Atala | Jan 2001 | B1 |
6174306 | Fleischmann | Jan 2001 | B1 |
6203563 | Fernandez | Mar 2001 | B1 |
6206931 | Cook et al. | Mar 2001 | B1 |
6207875 | Lindqvist et al. | Mar 2001 | B1 |
6213965 | Augustine et al. | Apr 2001 | B1 |
6213966 | Augustine | Apr 2001 | B1 |
6217535 | Augustine | Apr 2001 | B1 |
6235009 | Skow | May 2001 | B1 |
6235047 | Augustine et al. | May 2001 | B1 |
6241697 | Augustine | Jun 2001 | B1 |
6241698 | Augustine | Jun 2001 | B1 |
6241747 | Ruff | Jun 2001 | B1 |
6244311 | Hand et al. | Jun 2001 | B1 |
6248084 | Augustine et al. | Jun 2001 | B1 |
6254557 | Augustine et al. | Jul 2001 | B1 |
6254580 | Svedman | Jul 2001 | B1 |
6259067 | Faries, Jr. et al. | Jul 2001 | B1 |
6264622 | Augustine | Jul 2001 | B1 |
6264979 | Svedman | Jul 2001 | B1 |
6267740 | Augustine et al. | Jul 2001 | B1 |
6283931 | Augustine | Sep 2001 | B1 |
6284941 | Cox et al. | Sep 2001 | B1 |
6287316 | Agarwal et al. | Sep 2001 | B1 |
6290685 | Insley et al. | Sep 2001 | B1 |
6293917 | Augustine et al. | Sep 2001 | B1 |
6325798 | Edwards et al. | Dec 2001 | B1 |
6345623 | Heaton et al. | Feb 2002 | B1 |
6364853 | French et al. | Apr 2002 | B1 |
6394142 | Woelfel et al. | May 2002 | B1 |
6398767 | Fleischmann | Jun 2002 | B1 |
6410427 | Hu | Jun 2002 | B1 |
6440427 | Wadström | Aug 2002 | B1 |
6458109 | Henley et al. | Oct 2002 | B1 |
6471685 | Johnson | Oct 2002 | B1 |
6472581 | Muramatsu et al. | Oct 2002 | B1 |
6488643 | Tumey et al. | Dec 2002 | B1 |
6491682 | Paderni | Dec 2002 | B2 |
6491693 | Lytinas | Dec 2002 | B1 |
6493568 | Bell et al. | Dec 2002 | B1 |
6500112 | Khouri | Dec 2002 | B1 |
6520982 | Boynton et al. | Feb 2003 | B1 |
6553998 | Heaton et al. | Apr 2003 | B2 |
6557704 | Randolph | May 2003 | B1 |
6559773 | Berry | May 2003 | B1 |
6599277 | Neubert | Jul 2003 | B2 |
6626891 | Ohmstede | Sep 2003 | B2 |
6638270 | Johnson | Oct 2003 | B2 |
6648862 | Watson | Nov 2003 | B2 |
6663349 | Discenzo et al. | Dec 2003 | B1 |
6685681 | Lockwood et al. | Feb 2004 | B2 |
6691047 | Fredericks | Feb 2004 | B1 |
6695823 | Lina et al. | Feb 2004 | B1 |
6695824 | Howard et al. | Feb 2004 | B2 |
6719779 | Daoud | Apr 2004 | B2 |
6749592 | Lord | Jun 2004 | B2 |
6752794 | Lockwood et al. | Jun 2004 | B2 |
6755807 | Risk et al. | Jun 2004 | B2 |
6764462 | Petrosenko et al. | Jul 2004 | B2 |
6767334 | Randolph | Jul 2004 | B1 |
6800074 | Henley et al. | Oct 2004 | B2 |
6814079 | Heaton et al. | Nov 2004 | B2 |
6824533 | Risk et al. | Nov 2004 | B2 |
6855135 | Lockwood et al. | Feb 2005 | B2 |
6856821 | Johnson | Feb 2005 | B2 |
6936037 | Bubb et al. | Aug 2005 | B2 |
6951553 | Bubb et al. | Oct 2005 | B2 |
6966889 | Saab | Nov 2005 | B2 |
6979324 | Bybordi et al. | Dec 2005 | B2 |
6994702 | Johnson | Feb 2006 | B1 |
7004915 | Boynton et al. | Feb 2006 | B2 |
7022113 | Risk et al. | Apr 2006 | B2 |
7070584 | Johnson et al. | Jul 2006 | B2 |
7077832 | Fleischmann | Jul 2006 | B2 |
7108683 | Zamierowski | Sep 2006 | B2 |
7117869 | Heaton et al. | Oct 2006 | B2 |
7128735 | Weston | Oct 2006 | B2 |
7144390 | Hannigan et al. | Dec 2006 | B1 |
7195624 | Lockwood et al. | Mar 2007 | B2 |
7245291 | Sharif et al. | Jul 2007 | B2 |
7276051 | Henley et al. | Oct 2007 | B1 |
7338482 | Lockwood et al. | Mar 2008 | B2 |
7381211 | Zamierowski | Jun 2008 | B2 |
7422576 | Boynton et al. | Sep 2008 | B2 |
7524286 | Johnson | Apr 2009 | B2 |
7534927 | Lockwood et al. | May 2009 | B2 |
20010029956 | Argenta et al. | Oct 2001 | A1 |
20010034499 | Sessions et al. | Oct 2001 | A1 |
20010043943 | Coffey | Nov 2001 | A1 |
20010052681 | Deavila | Dec 2001 | A1 |
20020065494 | Lockwood et al. | May 2002 | A1 |
20020077661 | Saadat | Jun 2002 | A1 |
20020082567 | Lockwood et al. | Jun 2002 | A1 |
20020082668 | Ingman | Jun 2002 | A1 |
20020085952 | Ellingboe et al. | Jul 2002 | A1 |
20020115951 | Norstrem et al. | Aug 2002 | A1 |
20020115952 | Johnson et al. | Aug 2002 | A1 |
20020120185 | Johnson | Aug 2002 | A1 |
20020143286 | Tumey | Oct 2002 | A1 |
20020161317 | Risk et al. | Oct 2002 | A1 |
20020183702 | Henley et al. | Dec 2002 | A1 |
20020193723 | Batdorf, Sr. et al. | Dec 2002 | A1 |
20030032951 | Rittman, III et al. | Feb 2003 | A1 |
20030077311 | Vyakarnam et al. | Apr 2003 | A1 |
20030093041 | Risk et al. | May 2003 | A1 |
20030143352 | Yang et al. | Jul 2003 | A1 |
20030208149 | Coffey | Nov 2003 | A1 |
20030219469 | Johnson et al. | Nov 2003 | A1 |
20030225441 | Boynton et al. | Dec 2003 | A1 |
20040039415 | Zamierowski | Feb 2004 | A1 |
20040064111 | Lockwood et al. | Apr 2004 | A1 |
20040167482 | Watson | Aug 2004 | A1 |
20040225208 | Johnson | Nov 2004 | A1 |
20040243073 | Lockwood et al. | Dec 2004 | A1 |
20040249353 | Risks, Jr. et al. | Dec 2004 | A1 |
20040260230 | Randolph | Dec 2004 | A1 |
20050004534 | Lockwood et al. | Jan 2005 | A1 |
20050010153 | Lockwood et al. | Jan 2005 | A1 |
20050033197 | Cottler | Feb 2005 | A1 |
20050065484 | Watson, Jr. | Mar 2005 | A1 |
20050070858 | Lockwood et al. | Mar 2005 | A1 |
20050085795 | Lockwood et al. | Apr 2005 | A1 |
20050090787 | Risk et al. | Apr 2005 | A1 |
20050131327 | Lockwood et al. | Jun 2005 | A1 |
20050177190 | Zamierowski | Aug 2005 | A1 |
20050182445 | Zamierowski | Aug 2005 | A1 |
20050182446 | DeSantis | Aug 2005 | A1 |
20050234485 | Seegert et al. | Oct 2005 | A1 |
20050234510 | Zamierowski | Oct 2005 | A1 |
20050240220 | Zamierowski | Oct 2005 | A1 |
20050283105 | Heaton et al. | Dec 2005 | A1 |
20060015087 | Risk et al. | Jan 2006 | A1 |
20060029650 | Coffey | Feb 2006 | A1 |
20060029675 | Ginther | Feb 2006 | A1 |
20060041247 | Petrosenko et al. | Feb 2006 | A1 |
20060079852 | Bubb et al. | Apr 2006 | A1 |
20060129137 | Lockwood et al. | Jun 2006 | A1 |
20060149170 | Boynton et al. | Jul 2006 | A1 |
20060149171 | Vogel et al. | Jul 2006 | A1 |
20060173253 | Ganapathy et al. | Aug 2006 | A1 |
20060189910 | Johnson et al. | Aug 2006 | A1 |
20060213527 | Argenta et al. | Sep 2006 | A1 |
20070005028 | Risk, Jr. et al. | Jan 2007 | A1 |
20070014837 | Johnson et al. | Jan 2007 | A1 |
20070021697 | Ginther et al. | Jan 2007 | A1 |
20070021698 | Fleischmann | Jan 2007 | A1 |
20070032778 | Heaton et al. | Feb 2007 | A1 |
20070038172 | Zamierowski | Feb 2007 | A1 |
20070156104 | Lockwood et al. | Jul 2007 | A1 |
20070233022 | Henley et al. | Oct 2007 | A1 |
20090082740 | Lockwood et al. | Mar 2009 | A1 |
Number | Date | Country |
---|---|---|
550575 | Aug 1982 | AU |
745271 | Apr 1999 | AU |
755496 | Feb 2002 | AU |
1127488 | Jul 1982 | CA |
2005436 | Jun 1990 | CA |
2303085 | Mar 1999 | CA |
372727 | Mar 1923 | DE |
2640413 | Mar 1978 | DE |
28 09 828 | Sep 1978 | DE |
2809828 | Sep 1978 | DE |
3102674 | Sep 1982 | DE |
3539533 | May 1987 | DE |
40 12 232 | Oct 1991 | DE |
4111122 | Apr 1993 | DE |
4306478 | Sep 1994 | DE |
29504378 | Oct 1995 | DE |
29715634 | Nov 1997 | DE |
19722075 | Oct 1998 | DE |
64055 | Oct 1945 | DK |
0 100 148 | Feb 1984 | EP |
0117632 | Sep 1984 | EP |
0 161 865 | Nov 1985 | EP |
0 358 302 | Mar 1990 | EP |
0424165 | Apr 1991 | EP |
0485657 | May 1992 | EP |
0547496 | Jun 1993 | EP |
0853 950 | Jul 1998 | EP |
0 777 504 | Oct 1998 | EP |
0 880 953 | Dec 1998 | EP |
1 088 569 | Apr 2001 | EP |
1100574 | May 2001 | EP |
1190732 | Mar 2002 | EP |
1190732 | Mar 2002 | EP |
1 018 967 | Aug 2004 | EP |
1726276 | Nov 2006 | EP |
500253 | Mar 1920 | FR |
1303238 | Jul 1962 | FR |
3090 | Jun 1902 | GB |
641061 | Aug 1950 | GB |
692578 | Jun 1953 | GB |
1549756 | Aug 1979 | GB |
1584772 | Feb 1981 | GB |
2195255 | Apr 1988 | GB |
2197789 | Jun 1988 | GB |
2220357 | Jan 1990 | GB |
2235877 | Mar 1991 | GB |
2307180 | May 1997 | GB |
2329127 | Mar 1999 | GB |
2333965 | Aug 1999 | GB |
2336546 | Oct 1999 | GB |
2342584 | Apr 2000 | GB |
2344531 | Jun 2000 | GB |
2351025 | Dec 2000 | GB |
2356148 | May 2001 | GB |
199304 | Jan 1989 | HU |
51150 | Apr 1990 | HU |
205557 | Apr 1990 | HU |
P9006526 | Jan 1993 | HU |
P9302966 | Jul 1996 | HU |
76351 | Aug 1997 | HU |
215563 | Aug 1997 | HU |
1666 | Dec 1999 | HU |
4-129536 | Apr 1992 | JP |
06327761 | Nov 1994 | JP |
84485 | Oct 1935 | SE |
71559 | Apr 2002 | SG |
587941 | Jan 1978 | SU |
1268175 | Nov 1986 | SU |
WO 8002182 | Oct 1980 | WO |
WO 8704626 | Aug 1987 | WO |
WO 8904158 | May 1989 | WO |
WO 9010424 | Sep 1990 | WO |
WO 9011795 | Oct 1990 | WO |
WO 9100718 | Jan 1991 | WO |
WO9108793 | Jun 1991 | WO |
WO 9116030 | Oct 1991 | WO |
WO9212750 | Aug 1992 | WO |
WO9219313 | Nov 1992 | WO |
WO 9220299 | Nov 1992 | WO |
WO9309715 | Mar 1993 | WO |
WO 9309727 | May 1993 | WO |
WO 9400090 | Jan 1994 | WO |
WO 9420041 | Sep 1994 | WO |
WO 9605873 | Feb 1996 | WO |
WO 9615745 | May 1996 | WO |
WO9718007 | May 1997 | WO |
WO 9802205 | Jan 1998 | WO |
WO 9838944 | Sep 1998 | WO |
WO 9901173 | Jan 1999 | WO |
WO 9913793 | Mar 1999 | WO |
WO9923990 | May 1999 | WO |
WO 9959816 | Nov 1999 | WO |
WO 0007653 | Feb 2000 | WO |
WO 0015277 | Mar 2000 | WO |
WO 0021586 | Apr 2000 | WO |
WO 0026100 | May 2000 | WO |
WO 0028890 | May 2000 | WO |
WO 0030567 | Jun 2000 | WO |
WO 0032247 | Jun 2000 | WO |
WO 0038552 | Jul 2000 | WO |
WO 0038755 | Jul 2000 | WO |
WO 0042958 | Jul 2000 | WO |
WO 0059418 | Oct 2000 | WO |
WO 0059424 | Oct 2000 | WO |
WO 0061206 | Oct 2000 | WO |
WO 0064394 | Nov 2000 | WO |
WO 9605873 | Feb 2001 | WO |
WO 0134223 | May 2001 | WO |
WO 0137922 | May 2001 | WO |
WO 0149233 | Jul 2001 | WO |
WO 0185248 | Nov 2001 | WO |
WO 0185248 | Nov 2001 | WO |
WO 0189431 | Nov 2001 | WO |
WO0238091 | May 2002 | WO |
0243634 | Jun 2002 | WO |
WO 0243634 | Jun 2002 | WO |
WO 03005943 | Jan 2003 | WO |
WO 03045492 | Jun 2003 | WO |
WO 03057071 | Jul 2003 | WO |
WO 03057307 | Jul 2003 | WO |
WO 03101508 | Dec 2003 | WO |
Number | Date | Country | |
---|---|---|---|
20060041247 A1 | Feb 2006 | US |
Number | Date | Country | |
---|---|---|---|
60405010 | Aug 2002 | US |