Claims
- 1. A compound of the formula in which R10 is C1-6 alkyl, R11 is C1-4 alkyl, C1-4 alkoxy, phenyl, phenyl-C1-4 alkyl, R14-OOC-C1-4 alkyl or R14 -OOC-C2-4 alkenyl (in which R14 is hydrogen atom or C1-4 alkyl; R2 is hydrogen atom, hydroxy or C1-4 alkoxy; R3 is (i) hydrogen atom, (ii) C1-8 alkyl, (iii) C2-8 alkenyl, (iv) C2-8 alkynyl or (v) C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl, each substituted by 1-3 substituents, being same or different, selected from (1)-(5); (1) halogen atom, (2) C1-4 alkoxy, (3) C3-7 cycloalkyl, (4) phenyl, or (5) phenyl substituted by 1-3 substitutents selected from halogen atom, C1-4 alkyl, C1-4 alkoxy, nitro or trifluoromethyl; n is 0-4; is double bond or triple bond; is single bond, double bond or triple bond; with the proviso that, 1) when 5-6 position is triple bond, 13-14 position is not triple bond, 2) when 13-14 position is double bond represent E or Z form; non-toxic salt thereof, and cyclodextrin clathrate thereof. wherein R11 is C1-4 alkyl, C1-4 alkoxy, phenyl, phenyl-C1-4 alkyl, R14—OOC—C1-4 alkyl or R14—OOC—C2-4 alkenyl (in which R14 is hydrogen atom, C1-4 alkyl), the other symbols are the same meaning as hereinbefore defined.
- 2. A compound according to claim 1, which is(1) (5Z,8Z,11α,13E)-17,17-propano-11,16-dihydroxy-9-acetyloxy-prosta-5,8,13-trienonic acid.methylester in the form of the more or less polar stereoisomer on the 16-position or a mixture thereof.
Priority Claims (2)
Number |
Date |
Country |
Kind |
9-035499 |
Feb 1997 |
JP |
|
9-319169 |
Nov 1997 |
JP |
|
CROSS-REFERENCE TO RELATED APPLICATIONS
this application is a divisional application Ser. No. 09/018,565, filed Feb. 4, 1998 now U.S. Pat. No. 6,110,969.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
4061670 |
Floyd |
Dec 1977 |
A |
5698598 |
Woodward |
Dec 1997 |
A |