Claims
- 1. A compound of the formula ##STR7## wherein one of R.sub.1 and R.sub.2 is a straight-chain or branched oxoalkyl having from 5 to 8 carbon atoms; the oxygen atom of the oxoalkyl is attached to a non-terminal carbon atom, is separated from the nearest ring nitrogen atom by at least three carbon atoms when it is in the (.omega.-1)-position of the oxoalkyl and is separated from the nearest ring nitrogen atom by at least four carbon atoms when it is in a position other than the (.omega.-1)-position of the oxoalkyl;
- R.sub.2 is alkyl having up to 12 carbon atoms and the other of R.sub.1 and R.sub.3 is straight-chain or branched alkyl having from 1 to 12 carbon atoms; at least one of R.sub.1, R.sub.2 and R.sub.3 being alkyl having more than one carbon atom.
- 2. A compound according to claim 1 wherein the oxoalkyl has a carbonyl in the (.omega.-1)-position.
- 3. A compound according to claim 1 wherein the oxoalkyl is straight-chain oxoalkyl.
- 4. A compound according to claim 1 wherein at least one of R.sub.1 and R.sub.3 is alkyl having more than two carbon atoms and R.sub.2 is methyl.
- 5. A member according to claim 1 wherein R.sub.2 is methyl.
- 6. A compound according to claim 1 wherein at least one of R.sub.1, R.sub.2 and R.sub.3 is alkyl having more than two carbon atoms.
- 7. A 1-alkyl-3-methyl-7-(5-oxohexyl)-xanthine according to claim 1 wherein the alkyl is a straight-chain or branched member selected from the group consisting of propyl, n-butyl, isobutyl, n-hexyl, isohexyl, n-decyl and isodecyl.
- 8. A 1-(5-oxohexyl)-3-methyl-7-alkylxanthine according to claim 1 wherein the alkyl is a straight-chain or branched member selected from the group consisting of propyl, n-butyl, isobutyl, n-hexyl, isohexyl, n-decyl and isodecyl.
- 9. The compound according to claim 7 which is 1-(n-propyl)-3-methyl-7-(5-oxohexyl)-xanthine.
- 10. A compound according to claim 8 wherein the member is propyl.
- 11. A pharmaceutical composition comprising a pharmaceutical carrier or excipient and a member according to claim 1 in an amount and concentration which are effective to improve blood circulation of an arterial-blood-flow-deficient host to which the composition is administered.
- 12. A pharamceutical composition in dosage-unit form comprising active ingredient in association with a pharmaceutical carrier or excipient, the active ingredient comprising a compound as defined in claim 1 in an amount and concentration which are effective to improve blood circulation of a person having an arterial-blood-flow deficiency and to whom the composition is administered.
- 13. A pharmaceutically-acceptable and therapeutically useful injectable solution in sterile water containing from 10 to 400 mg per unit dose of a compound as defined in claim 1.
- 14. A composition according to claim 12 wherein each dosage unit contains from 10 to 400 mg of the active ingredient.
- 15. A process for treating a person suffering from an arterial bloodflow disturbance or vascular dilatory insufficiency which comprises administering to such person an effective amount of a compound according to claim 1 in the form of a pharmaceutical composition.
- 16. A process according to claim 15 wherein the pharmaceutical composition contains from 0.1 to 125 milligrams, per kilogram of body weight of the person, of said compound.
- 17. A process according to claim 15 for treating a person suffering from an arterial blood-flow disturbance.
- 18. A process according to claim 15 for treating a person suffering from a vascular dilatory insufficiency.
- 19. A process according to claim 15 for treating a person suffering a fibrinolytic-system disturbance.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2330742 |
Jun 1973 |
DEX |
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Parent Case Info
This application is a continuation of application Ser. No. 775,551, filed Mar. 8, 1977, which is a continuation-in-part application of U.S. application Ser. No. 531,048, filed Dec. 9, 1974 which again is a continuation-in-part application of U.S. application Ser. No. 479,434, filed June 14, 1974, all now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3864469 |
Reiser et al. |
Feb 1975 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
775551 |
Mar 1977 |
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Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
531048 |
Dec 1974 |
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Parent |
479434 |
Jun 1974 |
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