ALECTOR, LLC

Organization

SAN FRANCISCO, CA, US

Business Address
953 INDIANA STREET SAN FRANCISCO CA 94107 415-231-5660
Mailing Address
953 INDIANA STREET SAN FRANCISCO CA 94107
State Location
CA
State of Incorporation
DE

Organizations

Please log in for detailed analytics

Patents Grantslast 30 patents

Information Patent Grant
Siglec-9 ECD fusion molecules
- Patent number 11,987,612
- Issue date May 21, 2024
- ALECTOR LLC
- Spencer Liang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-Siglec-5 antibodies and methods of use thereof
- Patent number 11,965,023
- Issue date Apr 23, 2024
- ALECTOR LLC
- Kate Monroe
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Anti-MerTK antibodies and methods of use thereof
- Patent number 11,897,968
- Issue date Feb 13, 2024
- ALECTOR LLC
- Seung-Joo Lee
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-SIRP-alpha antibodies and methods of use thereof
- Patent number 11,779,642
- Issue date Oct 10, 2023
- ALECTOR LLC
- Andrew Pincetic
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-MS4A4A antibodies and methods of use thereof
- Patent number 11,667,699
- Issue date Jun 6, 2023
- ALECTOR LLC
- Jeonghoon Sun
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-Siglec-9 antibodies and methods of use thereof
- Patent number 11,667,710
- Issue date Jun 6, 2023
- ALECTOR LLC
- Arnon Rosenthal
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-TREM2 antibodies and methods of use thereof
- Patent number 11,634,489
- Issue date Apr 25, 2023
- ALECTOR LLC
- Tina Schwabe
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-MS4A4A antibodies and methods of use thereof
- Patent number 11,472,874
- Issue date Oct 18, 2022
- ALECTOR LLC
- Philip Kong
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Anti-TREM1 antibodies and methods of use thereof
- Patent number 11,472,877
- Issue date Oct 18, 2022
- ALECTOR LLC
- Andrew Pincetic
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Transgenic mice expressing human TREM proteins and methods of use t...
- Patent number 11,470,827
- Issue date Oct 18, 2022
- ALECTOR LLC
- Ilaria Tassi
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-TMEM106B antibodies and methods of use thereof
- Patent number 11,440,957
- Issue date Sep 13, 2022
- ALECTOR LLC
- Arnon Rosenthal
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Anti-Sortilin antibodies and methods of use thereof
- Patent number 11,396,546
- Issue date Jul 26, 2022
- ALECTOR LLC
- Tina Schwabe
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Anti-Siglec-7 antibodies and methods of use thereof
- Patent number 11,390,680
- Issue date Jul 19, 2022
- ALECTOR LLC
- Kate Monroe
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-siglec-5 antibodies and methods of use thereof
- Patent number 11,359,014
- Issue date Jun 14, 2022
- ALECTOR LLC
- Kate Monroe
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods of use of anti-Sortilin antibodies for treating a disease,...
- Patent number 11,339,223
- Issue date May 24, 2022
- ALECTOR LLC
- Arnon Rosenthal
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Anti-SIRPA antibodies and methods of use thereof
- Patent number 11,319,373
- Issue date May 3, 2022
- ALECTOR LLC
- Andrew Pincetic
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Anti-CD33 antibodies and methods of use thereof
- Patent number 11,254,743
- Issue date Feb 22, 2022
- ALECTOR LLC
- Patricia Culp
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Methods of increasing progranulin levels using anti-Sortilin antibo...
- Patent number 11,208,488
- Issue date Dec 28, 2021
- ALECTOR LLC
- Arnon Rosenthal
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Isolated nucleic acids encoding anti-sortilin antibodies
- Patent number 11,186,645
- Issue date Nov 30, 2021
- ALECTOR LLC
- Arnon Rosenthal
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Anti-CD33 antibodies and methods of use thereof
- Patent number 11,174,313
- Issue date Nov 16, 2021
- ALECTOR LLC
- Arnon Rosenthal
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Siglec transgenic mice and methods of use thereof
- Patent number 11,147,249
- Issue date Oct 19, 2021
- ALECTOR LLC
- Arnon Rosenthal
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Anti-CD33 antibodies and methods of use thereof
- Patent number 11,136,390
- Issue date Oct 5, 2021
- ALECTOR LLC
- Kate Monroe
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-TREM2 antibodies and methods of use thereof
- Patent number 11,084,875
- Issue date Aug 10, 2021
- ALECTOR LLC
- Kate Monroe
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Chimeric receptors and methods of use thereof
- Patent number 10,875,919
- Issue date Dec 29, 2020
- ALECTOR LLC
- Arnon Rosenthal
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Methods of screening for sortilin binding antagonists
- Patent number 10,849,992
- Issue date Dec 1, 2020
- ALECTOR LLC
- Arnon Rosenthal
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-Siglec-9 antibodies and methods of use thereof
- Patent number 10,800,844
- Issue date Oct 13, 2020
- ALECTOR LLC
- Arnon Rosenthal
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-CD33 antibodies and methods of use thereof
- Patent number 10,711,062
- Issue date Jul 14, 2020
- ALECTOR LLC
- Patricia Culp
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-TREM2 antibodies and methods of use thereof
- Patent number 10,676,525
- Issue date Jun 9, 2020
- ALECTOR LLC
- Tina Schwabe
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-siglec-7 antibodies and methods of use thereof
- Patent number 10,590,198
- Issue date Mar 17, 2020
- ALECTOR LLC
- Kate Monroe
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Anti-sortilin antibodies and methods of use thereof
- Patent number 10,428,150
- Issue date Oct 1, 2019
- ALECTOR LLC
- Arnon Rosenthal
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Please log in for detailed analytics

Patents Applicationslast 30 patents

Information Patent Application
ANTI-TMEM106B ANTIBODIES FOR TREATING AND PREVENTING CORONAVIRUS IN...
- Publication number 20240166738
- Publication date May 23, 2024
- ALECTOR LLC
- Herve RHINN
- C07 - ORGANIC CHEMISTRY
Information Patent Application
METHODS OF USE OF ANTI-SORTILIN ANTIBODIES
- Publication number 20240132597
- Publication date Apr 25, 2024
- ALECTOR LLC
- Robert PAUL
- G01 - MEASURING TESTING
Information Patent Application
METHODS OF USE OF ANTI-SORTILIN ANTIBODIES
- Publication number 20240101681
- Publication date Mar 28, 2024
- ALECTOR LLC
- Arnon ROSENTHAL
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Anti-SIRP-Alpha Antibodies and Methods of Use Thereof
- Publication number 20240082395
- Publication date Mar 14, 2024
- ALECTOR LLC
- Andrew Pincetic
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ANTI-MS4A4A ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20240076362
- Publication date Mar 7, 2024
- ALECTOR LLC
- Jeonghoon SUN
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ANTI-SIGLEC-9 ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20240067723
- Publication date Feb 29, 2024
- ALECTOR LLC
- Arnon ROSENTHAL
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ANTI-TMEM106B ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20230303681
- Publication date Sep 28, 2023
- ALECTOR LLC
- Arnon ROSENTHAL
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ANTI-TREM2 ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20230295297
- Publication date Sep 21, 2023
- ALECTOR LLC
- Tina SCHWABE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PILRA ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20230220074
- Publication date Jul 13, 2023
- ALECTOR LLC
- Spencer LIANG
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS OF USE OF ANTI-TREM2 ANTIBODIES
- Publication number 20230183341
- Publication date Jun 15, 2023
- ALECTOR LLC
- Robert PAUL
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS OF USE OF ANTI-TREM2 ANTIBODIES
- Publication number 20230159637
- Publication date May 25, 2023
- ALECTOR LLC
- Francesca CIGNARELLA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ANTI-MS4A4A ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20230142579
- Publication date May 11, 2023
- ALECTOR LLC
- Philip KONG
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ANTI-MS4A4A ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20230126400
- Publication date Apr 27, 2023
- ALECTOR LLC
- Philip KONG
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Anti-TREM1 Antibodies and Methods of Use Thereof
- Publication number 20230121869
- Publication date Apr 20, 2023
- ALECTOR LLC
- Andrew Pincetic
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ANTI-TREM2 ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20230107639
- Publication date Apr 6, 2023
- ALECTOR LLC
- Kate MONROE
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ANTI-SORTILIN ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20230047941
- Publication date Feb 16, 2023
- ALECTOR LLC
- Tina SCHWABE
- C07 - ORGANIC CHEMISTRY
Information Patent Application
METHODS OF USE OF ANTI-CD33 ANTIBODIES
- Publication number 20230035072
- Publication date Feb 2, 2023
- ALECTOR LLC
- Robert PAUL
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS OF USE OF ANTI-TREM2 ANTIBODIES
- Publication number 20230024528
- Publication date Jan 26, 2023
- ALECTOR LLC
- Tina SCHWABE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ANTI-SIGLEC-7 ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20220411503
- Publication date Dec 29, 2022
- ALECTOR LLC
- Kate MONROE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ANTI-MS4A6A ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20220380455
- Publication date Dec 1, 2022
- ALECTOR LLC
- Philip KONG
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ANTI-SORTILIN ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20220348656
- Publication date Nov 3, 2022
- ALECTOR LLC
- Tina SCHWABE
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ANTI-SIGLEC-5 ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20220315656
- Publication date Oct 6, 2022
- ALECTOR LLC
- Kate MONROE
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Anti-SIRPa Antibodies and Methods of Use Thereof
- Publication number 20220289844
- Publication date Sep 15, 2022
- ALECTOR LLC
- Andrew Pincetic
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANTI-CD33 ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20220281976
- Publication date Sep 8, 2022
- ALECTOR LLC
- Arnon ROSENTHAL
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
ANTI-CD33 ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20220251190
- Publication date Aug 11, 2022
- ALECTOR LLC
- Kate MONROE
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS OF USE OF ANTI-SORTILIN ANTIBODIES FOR TREATING A DISEASE,...
- Publication number 20220251219
- Publication date Aug 11, 2022
- ALECTOR LLC
- Arnon ROSENTHAL
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS OF INCREASING PROGRANULIN LEVELS USING ANTI-SORTILIN ANTIBO...
- Publication number 20220185899
- Publication date Jun 16, 2022
- ALECTOR LLC
- Arnon ROSENTHAL
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
METHODS OF USE OF ANTI-SORTILIN ANTIBODIES FOR TREATING A DISEASE,...
- Publication number 20220185898
- Publication date Jun 16, 2022
- ALECTOR LLC
- Arnon ROSENTHAL
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ANTI-CD33 ANTIBODIES AND METHODS OF USE THEREOF
- Publication number 20220162309
- Publication date May 26, 2022
- ALECTOR LLC
- Patricia Culp
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SIGLEC TRANSGENIC MICE AND METHODS OF USE THEREOF
- Publication number 20220000083
- Publication date Jan 6, 2022
- ALECTOR LLC
- Arnon ROSENTHAL
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING

Please log in for detailed analytics

Trademarklast 30 trademarks

Information Trademark
90822308 - LEARNFTD
- Serial number 90822308
- Registration number 6741481
- Filing date Jul 12, 2021
- Alector LLC
- 44 - Medical services
Information Trademark
90769305
- Serial number 90769305
- Filing date Jun 11, 2021
- Alector LLC
- 5 - Pharmaceutical and veterinary preparations
Information Trademark
90769356 - ALECTOR
- Serial number 90769356
- Filing date Jun 11, 2021
- Alector LLC
- 5 - Pharmaceutical and veterinary preparations
Information Trademark
90769323
- Serial number 90769323
- Registration number 6965447
- Filing date Jun 11, 2021
- Alector LLC
- 42 - Scientific and technological services and research and design relating thereto
Information Trademark
90979005
- Serial number 90979005
- Registration number 7007659
- Filing date Jun 11, 2021
- Alector LLC
- 44 - Medical services
Information Trademark
90979006 - ALECTOR
- Serial number 90979006
- Registration number 7007660
- Filing date Jun 11, 2021
- Alector LLC
- 44 - Medical services
Information Trademark
90769335
- Serial number 90769335
- Filing date Jun 11, 2021
- Alector LLC
- 44 - Medical services
Information Trademark
90769363 - ALECTOR
- Serial number 90769363
- Registration number 6965449
- Filing date Jun 11, 2021
- Alector LLC
- 42 - Scientific and technological services and research and design relating thereto
Information Trademark
90769372 - ALECTOR
- Serial number 90769372
- Filing date Jun 11, 2021
- Alector LLC
- 44 - Medical services
Information Trademark
90296467 - FINDFTD
- Serial number 90296467
- Filing date Nov 3, 2020
- Alector LLC
- 42 - Scientific and technological services and research and design relating thereto
Information Trademark
90975354 - ALECTOR
- Serial number 90975354
- Registration number 6480737
- Filing date Jun 16, 2020
- Alector LLC
- 42 - Scientific and technological services and research and design relating thereto
Information Trademark
90004507 - ALECTOR
- Serial number 90004507
- Filing date Jun 16, 2020
- Alector LLC
- 5 - Pharmaceutical and veterinary preparations
Information Trademark
88593315 - ALECTOR
- Serial number 88593315
- Registration number 6159769
- Filing date Aug 26, 2019
- Alector LLC
- 42 - Scientific and technological services and research and design relating thereto
Information Trademark
88383919
- Serial number 88383919
- Filing date Apr 12, 2019
- Alector LLC
- 5 - Pharmaceutical and veterinary preparations
Information Trademark
87917395 - ALECTOR
- Serial number 87917395
- Registration number 6080700
- Filing date May 11, 2018
- Alector LLC
- 5 - Pharmaceutical and veterinary preparations

NIH Research Projectlast 12 months

processing...

Count: 2

Research Projects

Information Research Project
SORT1:PGRN blocking antibodies for Frontotemporal dementia
- Application id 9322703
- Award notice date Sep 17, 2016
Information Research Project
SORT1:PGRN blocking antibodies for Frontotemporal dementia
- Application id 8905365
- Award notice date Sep 7, 2015

ALECTOR, LLC

Organization

Business Address

Mailing Address

State Location

State of Incorporation

Patents Grantslast 30 patents

Siglec-9 ECD fusion molecules

Anti-Siglec-5 antibodies and methods of use thereof

Anti-MerTK antibodies and methods of use thereof

Anti-SIRP-alpha antibodies and methods of use thereof

Anti-MS4A4A antibodies and methods of use thereof

Anti-Siglec-9 antibodies and methods of use thereof

Anti-TREM2 antibodies and methods of use thereof

Anti-MS4A4A antibodies and methods of use thereof

Anti-TREM1 antibodies and methods of use thereof

Transgenic mice expressing human TREM proteins and methods of use t...

Anti-TMEM106B antibodies and methods of use thereof

Anti-Sortilin antibodies and methods of use thereof

Anti-Siglec-7 antibodies and methods of use thereof

Anti-siglec-5 antibodies and methods of use thereof

Methods of use of anti-Sortilin antibodies for treating a disease,...

Anti-SIRPA antibodies and methods of use thereof

Anti-CD33 antibodies and methods of use thereof

Methods of increasing progranulin levels using anti-Sortilin antibo...

Isolated nucleic acids encoding anti-sortilin antibodies

Anti-CD33 antibodies and methods of use thereof

Siglec transgenic mice and methods of use thereof

Anti-CD33 antibodies and methods of use thereof

Anti-TREM2 antibodies and methods of use thereof

Chimeric receptors and methods of use thereof

Methods of screening for sortilin binding antagonists

Anti-Siglec-9 antibodies and methods of use thereof

Anti-CD33 antibodies and methods of use thereof

Anti-TREM2 antibodies and methods of use thereof

Anti-siglec-7 antibodies and methods of use thereof

Anti-sortilin antibodies and methods of use thereof

Patents Applicationslast 30 patents

ANTI-TMEM106B ANTIBODIES FOR TREATING AND PREVENTING CORONAVIRUS IN...

METHODS OF USE OF ANTI-SORTILIN ANTIBODIES

METHODS OF USE OF ANTI-SORTILIN ANTIBODIES

Anti-SIRP-Alpha Antibodies and Methods of Use Thereof

ANTI-MS4A4A ANTIBODIES AND METHODS OF USE THEREOF

ANTI-SIGLEC-9 ANTIBODIES AND METHODS OF USE THEREOF

ANTI-TMEM106B ANTIBODIES AND METHODS OF USE THEREOF

ANTI-TREM2 ANTIBODIES AND METHODS OF USE THEREOF

PILRA ANTIBODIES AND METHODS OF USE THEREOF

METHODS OF USE OF ANTI-TREM2 ANTIBODIES

METHODS OF USE OF ANTI-TREM2 ANTIBODIES

ANTI-MS4A4A ANTIBODIES AND METHODS OF USE THEREOF

ANTI-MS4A4A ANTIBODIES AND METHODS OF USE THEREOF

Anti-TREM1 Antibodies and Methods of Use Thereof

ANTI-TREM2 ANTIBODIES AND METHODS OF USE THEREOF

ANTI-SORTILIN ANTIBODIES AND METHODS OF USE THEREOF

METHODS OF USE OF ANTI-CD33 ANTIBODIES

METHODS OF USE OF ANTI-TREM2 ANTIBODIES

ANTI-SIGLEC-7 ANTIBODIES AND METHODS OF USE THEREOF

ANTI-MS4A6A ANTIBODIES AND METHODS OF USE THEREOF

ANTI-SORTILIN ANTIBODIES AND METHODS OF USE THEREOF

ANTI-SIGLEC-5 ANTIBODIES AND METHODS OF USE THEREOF

Anti-SIRPa Antibodies and Methods of Use Thereof

ANTI-CD33 ANTIBODIES AND METHODS OF USE THEREOF

ANTI-CD33 ANTIBODIES AND METHODS OF USE THEREOF

METHODS OF USE OF ANTI-SORTILIN ANTIBODIES FOR TREATING A DISEASE,...

METHODS OF INCREASING PROGRANULIN LEVELS USING ANTI-SORTILIN ANTIBO...

METHODS OF USE OF ANTI-SORTILIN ANTIBODIES FOR TREATING A DISEASE,...

ANTI-CD33 ANTIBODIES AND METHODS OF USE THEREOF

SIGLEC TRANSGENIC MICE AND METHODS OF USE THEREOF

Trademarklast 30 trademarks

90822308 - LEARNFTD

90769305

90769356 - ALECTOR

90769323

90979005

90979006 - ALECTOR

90769335

90769363 - ALECTOR

90769372 - ALECTOR

90296467 - FINDFTD

90975354 - ALECTOR