Hua Bai

Person

Taizhou, CN

People

Patents Grantslast 30 patents

Information Patent Grant
Pyrimidine derivative, method for preparing same and use thereof in...
- Patent number 11,827,625
- Issue date Nov 28, 2023
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Lei Chen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Pyrimidine derivative, method for preparing same and use thereof in...
- Patent number 11,001,572
- Issue date May 11, 2021
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Lei Chen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Spinosad heterologous expression strain and construction method the...
- Patent number 10,844,415
- Issue date Nov 24, 2020
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Jun Huang
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Pyrimidine derivative, method for preparing same and use thereof in...
- Patent number 10,654,836
- Issue date May 19, 2020
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Lei Chen
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Streptomyces and method for producing milbemycin A4 using same
- Patent number 10,526,668
- Issue date Jan 7, 2020
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Yun Teng
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Acrylic acid derivative, preparation method and use in medicine the...
- Patent number 10,519,148
- Issue date Dec 31, 2019
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Dongliang Guan
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Intermediate compounds for preparation of praziquantel and processe...
- Patent number 10,508,112
- Issue date Dec 17, 2019
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Fuli Zhang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Process for preparing AD-35
- Patent number 10,399,992
- Issue date Sep 3, 2019
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Jinqing Zhong
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Method for preparing azetidinone compound and intermediate of azeti...
- Patent number 10,364,219
- Issue date Jul 30, 2019
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Hua Bai
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Recombinant microorganism expressing avermectin analogue and use th...
- Patent number 10,334,850
- Issue date Jul 2, 2019
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Jun Huang
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Fidaxomicin purification method
- Patent number 10,316,052
- Issue date Jun 11, 2019
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Huijun Ren
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Disaccharide intermediate and synthesis method thereof
- Patent number 10,287,309
- Issue date May 14, 2019
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Yanghui Guo
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Streptomyces and method for producing milbemycin A3 using same
- Patent number 10,287,545
- Issue date May 14, 2019
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Yun Teng
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Substituted pyrazoles as inhibitors of fibroblast growth factor rec...
- Patent number 10,214,515
- Issue date Feb 26, 2019
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Lei Chen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Preparation method for praziquantel and intermediate compounds thereof
- Patent number 10,035,798
- Issue date Jul 31, 2018
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Fuli Zhang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Sixteen-membered macrolide compound and applications thereof
- Patent number 10,028,507
- Issue date Jul 24, 2018
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Jun Huang
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Bacterial strain of Actinoplanes sp. and application thereof
- Patent number 9,982,314
- Issue date May 29, 2018
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Hao Xu
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Method for preparing azetidinone compound and intermediate of azeti...
- Patent number 9,926,268
- Issue date Mar 27, 2018
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Hua Bai
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Targeting thymidine kinase photosensitizer and pharmaceutical compo...
- Patent number 9,872,903
- Issue date Jan 23, 2018
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD
- Ravindra K Pandey
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Cyanine dye compound and preparation method therefor, and dual-func...
- Patent number 9,821,062
- Issue date Nov 21, 2017
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Ravindra K. Pandey
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Crystal forms of azetidinone compounds and preparing methods thereof
- Patent number 9,802,891
- Issue date Oct 31, 2017
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Hongyuan Wei
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Crystal forms of azetidinone compounds and preparing methods thereof
- Patent number 9,776,959
- Issue date Oct 3, 2017
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Hongyuan Wei
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Ginsenoside C-K polymorphic compounds and method for preparing same
- Patent number 9,670,245
- Issue date Jun 6, 2017
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Guobin Ren
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Two crystal forms of ginsenoside C-K and method for preparing same
- Patent number 9,643,992
- Issue date May 9, 2017
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Guobin Ren
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Preparation of new intermediate of heparin pentasaccharide and prep...
- Patent number 9,624,315
- Issue date Apr 18, 2017
- Zhejiang Hisum Pharmaceutical Co., Ltd.
- Yanghui Guo
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Crystal forms of azetidinone compounds and preparing methods thereof
- Patent number 9,567,298
- Issue date Feb 14, 2017
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Hongyuan Wei
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
4-((substituted phenyl) difluoromethyl) phenoxy carboxylic acid der...
- Patent number 9,487,470
- Issue date Nov 8, 2016
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Hua Bai
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Preparation method for rivastigmine, intermediates thereof, and pre...
- Patent number 9,353,049
- Issue date May 31, 2016
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Fuli Zhang
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Compounds having activating effect on subtypes of peroxisome prolif...
- Patent number 9,346,770
- Issue date May 24, 2016
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Yaping Wang
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Benzodioxole derivative and preparation method and use thereof
- Patent number 9,346,818
- Issue date May 24, 2016
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Hua Bai
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Patents Applicationslast 30 patents

Information Patent Application
Pyrimidine Derivative, Method For Preparing Same And Use Thereof In...
- Publication number 20240018130
- Publication date Jan 18, 2024
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Lei Chen
- C07 - ORGANIC CHEMISTRY
Information Patent Application
METHOD FOR LARGE-SCALE SYNTHESIS OF TETRODOTOXIN
- Publication number 20230312596
- Publication date Oct 5, 2023
- Shanghai Shengping Medical Equipment Co., Ltd.
- Guangyin WANG
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Pyrimidine Derivative, Method For Preparing Same And Use Thereof In...
- Publication number 20210221797
- Publication date Jul 22, 2021
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Lei Chen
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Pyrimidine Derivative, Method For Preparing Same And Use Thereof In...
- Publication number 20200207745
- Publication date Jul 2, 2020
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Lei Chen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
Pyrimidine Derivative, Method For Preparing Same And Use Thereof In...
- Publication number 20190161476
- Publication date May 30, 2019
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Lei Chen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CRYSTAL FORM A OF MILBEMYCIN A3 OXIME AND PREPARATION METHOD THEREOF
- Publication number 20190152986
- Publication date May 23, 2019
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Yun TENG
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Process For Preparing AD-35
- Publication number 20190100527
- Publication date Apr 4, 2019
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Jinqing Zhong
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
STREPTOMYCES AND METHOD FOR PRODUCING MILBEMYCIN A4 USING SAME
- Publication number 20190048427
- Publication date Feb 14, 2019
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Yun Teng
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
INTERMEDIATE COMPOUNDS FOR PREPARATION OF PRAZIQUANTEL AND PROCESSE...
- Publication number 20180297998
- Publication date Oct 18, 2018
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Fuli ZHANG
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ACRYLIC ACID DERIVATIVE, PREPARATION METHOD AND USE IN MEDICINE THE...
- Publication number 20180291019
- Publication date Oct 11, 2018
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Dongliang Guan
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
INDOLE DERIVATIVE, PREPARATION METHOD THEREOF, AND USE THEREOF IN P...
- Publication number 20180194751
- Publication date Jul 12, 2018
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Lei Chen
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
FIDAXOMICIN PURIFICATION METHOD
- Publication number 20180179244
- Publication date Jun 28, 2018
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD
- Huijun REN
- C07 - ORGANIC CHEMISTRY
Information Patent Application
STREPTOMYCES AND METHOD FOR PRODUCING MILBEMYCIN A3 USING SAME
- Publication number 20180171283
- Publication date Jun 21, 2018
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Yun Teng
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
METHOD FOR PREPARING AZETIDINONE COMPOUND AND INTERMEDIATE OF AZETI...
- Publication number 20180099930
- Publication date Apr 12, 2018
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Hua BAI
- C07 - ORGANIC CHEMISTRY
Information Patent Application
CYCLIC PEPTIDE COMPOUND, AND PREPARATION AND USE THEREOF
- Publication number 20180057530
- Publication date Mar 1, 2018
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Hua Bai
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PREPARATION METHOD FOR PRAZIQUANTEL AND INTERMEDIATE COMPOUNDS THEREOF
- Publication number 20180030049
- Publication date Feb 1, 2018
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Fuli ZHANG
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SPINOSAD HETEROLOGOUS EXPRESSION STRAIN AND CONSTRUCTION METHOD THE...
- Publication number 20180016610
- Publication date Jan 18, 2018
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Jun HUANG
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SIXTEEN-MEMBERED MACROLIDE COMPOUND AND APPLICATIONS THEREOF
- Publication number 20170127678
- Publication date May 11, 2017
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Jun Huang
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
METHOD FOR PREPARING AZETIDINONE COMPOUND AND INTERMEDIATE OF AZETI...
- Publication number 20170121281
- Publication date May 4, 2017
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Hua BAI
- C07 - ORGANIC CHEMISTRY
Information Patent Application
CRYSTAL FORMS OF AZETIDINONE COMPOUNDS AND PREPARING METHODS THEREOF
- Publication number 20170114015
- Publication date Apr 27, 2017
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Hongyuan Wei
- C07 - ORGANIC CHEMISTRY
Information Patent Application
CRYSTAL FORMS OF AZETIDINONE COMPOUNDS AND PREPARING METHODS THEREOF
- Publication number 20170114016
- Publication date Apr 27, 2017
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Hongyuan Wei
- C07 - ORGANIC CHEMISTRY
Information Patent Application
RECOMBINANT MICROORGANISM EXPRESSING AVERMECTIN ANALOGUE AND USE TH...
- Publication number 20170013837
- Publication date Jan 19, 2017
- Zhejiang Hisun Pharmaceutical Co. Ltd
- Jun Huang
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
DISACCHARIDE INTERMEDIATE AND SYNTHESIS METHOD THEREOF
- Publication number 20160264609
- Publication date Sep 15, 2016
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Yanghui Guo
- C07 - ORGANIC CHEMISTRY
Information Patent Application
BACTERIAL STRAIN OF ACTINOPLANES SP. AND APPLICATION THEREOF
- Publication number 20160265071
- Publication date Sep 15, 2016
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Hao XU
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
TARGETING THYMIDINE KINASE PHOTOSENSITIZER AND PHARMACEUTICAL COMPO...
- Publication number 20160151494
- Publication date Jun 2, 2016
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- RAVINDRA K PANDEY
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
CYANINE DYE COMPOUND AND PREPARATION METHOD THEREFOR, AND DUAL-FUNC...
- Publication number 20150329490
- Publication date Nov 19, 2015
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Ravindra K. PANDEY
- C09 - DYES PAINTS POLISHES NATURAL RESINS ADHESIVES MISCELLANEOUS COMPOSITION...
Information Patent Application
PREPARATION OF NEW INTERMEDIATE OF HEPARIN PENTASACCHARIDE AND PREP...
- Publication number 20150299340
- Publication date Oct 22, 2015
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Yanghui Guo
- C08 - ORGANIC MACROMOLECULAR COMPOUNDS THEIR PREPARATION OR CHEMICAL WORKING-...
Information Patent Application
METHOD FOR PREPARING HIGHLY PURE DOXORUBICIN
- Publication number 20150299241
- Publication date Oct 22, 2015
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Hua Chen
- C07 - ORGANIC CHEMISTRY
Information Patent Application
METHOD FOR PREPARING FULLY PROTECTION HEPARIN PENTASACCHARIDE AND I...
- Publication number 20150284419
- Publication date Oct 8, 2015
- Zhejiang Hisun Pharmaceutical Co., Ltd.
- Yili Ding
- C07 - ORGANIC CHEMISTRY
Information Patent Application
CRYSTAL FORMS OF AZETIDINONE COMPOUNDS AND PREPARING METHODS THEREOF
- Publication number 20150218091
- Publication date Aug 6, 2015
- ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.
- Hongyuan Wei
- C07 - ORGANIC CHEMISTRY

Person

Patents Grantslast 30 patents

Pyrimidine derivative, method for preparing same and use thereof in...

Pyrimidine derivative, method for preparing same and use thereof in...

Spinosad heterologous expression strain and construction method the...

Pyrimidine derivative, method for preparing same and use thereof in...

Streptomyces and method for producing milbemycin A4 using same

Acrylic acid derivative, preparation method and use in medicine the...

Intermediate compounds for preparation of praziquantel and processe...

Process for preparing AD-35

Method for preparing azetidinone compound and intermediate of azeti...

Recombinant microorganism expressing avermectin analogue and use th...

Fidaxomicin purification method

Disaccharide intermediate and synthesis method thereof

Streptomyces and method for producing milbemycin A3 using same

Substituted pyrazoles as inhibitors of fibroblast growth factor rec...

Preparation method for praziquantel and intermediate compounds thereof

Sixteen-membered macrolide compound and applications thereof

Bacterial strain of Actinoplanes sp. and application thereof

Method for preparing azetidinone compound and intermediate of azeti...

Targeting thymidine kinase photosensitizer and pharmaceutical compo...

Cyanine dye compound and preparation method therefor, and dual-func...

Crystal forms of azetidinone compounds and preparing methods thereof

Crystal forms of azetidinone compounds and preparing methods thereof

Ginsenoside C-K polymorphic compounds and method for preparing same

Two crystal forms of ginsenoside C-K and method for preparing same

Preparation of new intermediate of heparin pentasaccharide and prep...

Crystal forms of azetidinone compounds and preparing methods thereof

4-((substituted phenyl) difluoromethyl) phenoxy carboxylic acid der...

Preparation method for rivastigmine, intermediates thereof, and pre...

Compounds having activating effect on subtypes of peroxisome prolif...

Benzodioxole derivative and preparation method and use thereof

Patents Applicationslast 30 patents

Pyrimidine Derivative, Method For Preparing Same And Use Thereof In...

METHOD FOR LARGE-SCALE SYNTHESIS OF TETRODOTOXIN

Pyrimidine Derivative, Method For Preparing Same And Use Thereof In...

Pyrimidine Derivative, Method For Preparing Same And Use Thereof In...

Pyrimidine Derivative, Method For Preparing Same And Use Thereof In...

CRYSTAL FORM A OF MILBEMYCIN A3 OXIME AND PREPARATION METHOD THEREOF

Process For Preparing AD-35

STREPTOMYCES AND METHOD FOR PRODUCING MILBEMYCIN A4 USING SAME

INTERMEDIATE COMPOUNDS FOR PREPARATION OF PRAZIQUANTEL AND PROCESSE...

ACRYLIC ACID DERIVATIVE, PREPARATION METHOD AND USE IN MEDICINE THE...

INDOLE DERIVATIVE, PREPARATION METHOD THEREOF, AND USE THEREOF IN P...

FIDAXOMICIN PURIFICATION METHOD

STREPTOMYCES AND METHOD FOR PRODUCING MILBEMYCIN A3 USING SAME

METHOD FOR PREPARING AZETIDINONE COMPOUND AND INTERMEDIATE OF AZETI...

CYCLIC PEPTIDE COMPOUND, AND PREPARATION AND USE THEREOF

PREPARATION METHOD FOR PRAZIQUANTEL AND INTERMEDIATE COMPOUNDS THEREOF

SPINOSAD HETEROLOGOUS EXPRESSION STRAIN AND CONSTRUCTION METHOD THE...

SIXTEEN-MEMBERED MACROLIDE COMPOUND AND APPLICATIONS THEREOF

METHOD FOR PREPARING AZETIDINONE COMPOUND AND INTERMEDIATE OF AZETI...

CRYSTAL FORMS OF AZETIDINONE COMPOUNDS AND PREPARING METHODS THEREOF

CRYSTAL FORMS OF AZETIDINONE COMPOUNDS AND PREPARING METHODS THEREOF

RECOMBINANT MICROORGANISM EXPRESSING AVERMECTIN ANALOGUE AND USE TH...

DISACCHARIDE INTERMEDIATE AND SYNTHESIS METHOD THEREOF

BACTERIAL STRAIN OF ACTINOPLANES SP. AND APPLICATION THEREOF

TARGETING THYMIDINE KINASE PHOTOSENSITIZER AND PHARMACEUTICAL COMPO...

CYANINE DYE COMPOUND AND PREPARATION METHOD THEREFOR, AND DUAL-FUNC...

PREPARATION OF NEW INTERMEDIATE OF HEPARIN PENTASACCHARIDE AND PREP...

METHOD FOR PREPARING HIGHLY PURE DOXORUBICIN

METHOD FOR PREPARING FULLY PROTECTION HEPARIN PENTASACCHARIDE AND I...

CRYSTAL FORMS OF AZETIDINONE COMPOUNDS AND PREPARING METHODS THEREOF