John P. Wikswo

Person

Brentwood, TN, US

People

Patents Grantslast 30 patents

Information Patent Grant
Continuous automated perfusion culture analysis system (CAPCAS) and...
- Patent number 11,939,563
- Issue date Mar 26, 2024
- Vanderbilt University
- Ronald S. Reiserer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Massively parallel, multiple-organ perfusion control system
- Patent number 11,746,317
- Issue date Sep 5, 2023
- Vanderbilt University
- Ronald S. Reiserer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Microfluidic systems, pumps, valves, fluidic chips thereof, and app...
- Patent number 11,745,180
- Issue date Sep 5, 2023
- Vanderbilt University
- Ronald S. Reiserer
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Microfluidic systems, pumps, valves, fluidic chips thereof, and app...
- Patent number 11,565,256
- Issue date Jan 31, 2023
- Vanderbilt University
- Ronald S. Reiserer
- F04 - POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS PUMPS FOR LIQUIDS OR ELASTIC...
Information Patent Grant
Robots and robotic systems for fluid handling and transport of biod...
- Patent number 11,474,531
- Issue date Oct 18, 2022
- Vanderbilt University
- Ronald S. Reiserer
- B60 - VEHICLES IN GENERAL
Information Patent Grant
Cartridge systems, capacitive pumps and multi-throw valves and pump...
- Patent number 11,465,144
- Issue date Oct 11, 2022
- Vanderbilt University
- David K. Schaffer
- F16 - ENGINEERING ELEMENTS AND UNITS GENERAL MEASURES FOR PRODUCING AND MAINT...
Information Patent Grant
Continuous automated perfusion culture analysis system (CAPCAS) and...
- Patent number 11,447,734
- Issue date Sep 20, 2022
- Vanderbilt University
- Ronald S. Reiserer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Multichannel pumps and applications of same
- Patent number 11,384,751
- Issue date Jul 12, 2022
- Vanderbilt University
- John P. Wikswo
- F04 - POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS PUMPS FOR LIQUIDS OR ELASTIC...
Information Patent Grant
Cartridge systems, capacitive pumps and multi-throw valves and pump...
- Patent number 11,135,582
- Issue date Oct 5, 2021
- Vanderbilt University
- David K. Schaffer
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Devices and methods for tension measurements and applications of same
- Patent number 10,876,942
- Issue date Dec 29, 2020
- Vanderbilt University
- John P. Wikswo
- G02 - OPTICS
Information Patent Grant
Peristaltic micropump and related systems and methods
- Patent number 10,781,809
- Issue date Sep 22, 2020
- Vanderbilt University
- Parker A. Gould
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Devices and methods for tension measurements and applications of same
- Patent number 10,761,001
- Issue date Sep 1, 2020
- Vanderbilt University
- John P. Wikswo
- G01 - MEASURING TESTING
Information Patent Grant
Bio-assessment device and method of making the device
- Patent number 10,634,665
- Issue date Apr 28, 2020
- Triad National Security, LLC
- Rashi Iyer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
High-throughput, multi-omics approach to determine and validate de...
- Patent number 10,607,721
- Issue date Mar 31, 2020
- Vanderbilt University
- Richard Caprioli
- G01 - MEASURING TESTING
Information Patent Grant
Interconnections of multiple perfused engineered tissue constructs...
- Patent number 10,577,574
- Issue date Mar 3, 2020
- Vanderbilt University
- John P. Wikswo
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
System and method for microdialysis imaging and regional fluidic de...
- Patent number 10,538,726
- Issue date Jan 21, 2020
- Vanderbilt University
- John P. Wikswo
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Multicompartment layered and stackable microfluidic bioreactors and...
- Patent number 10,532,354
- Issue date Jan 14, 2020
- Vanderbilt University
- John P. Wikswo
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Peristaltic micropump and related systems and methods
- Patent number 10,487,819
- Issue date Nov 26, 2019
- Vanderbilt University
- Parker A. Gould
- F04 - POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS PUMPS FOR LIQUIDS OR ELASTIC...
Information Patent Grant
Multicompartment layered and stackable microfluidic bioreactors and...
- Patent number 10,464,064
- Issue date Nov 5, 2019
- Vanderbilt University
- John P. Wikswo
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Grant
Integrated organ-on-chip systems and applications of the same
- Patent number 10,444,223
- Issue date Oct 15, 2019
- Vanderbilt University
- John P. Wikswo
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Organ on chip integration and applications of the same
- Patent number 10,119,622
- Issue date Nov 6, 2018
- Vanderbilt University
- Frank E. Block
- F04 - POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS PUMPS FOR LIQUIDS OR ELASTIC...
Information Patent Grant
Integrated organ-on-chip systems and applications of the same
- Patent number 10,078,075
- Issue date Sep 18, 2018
- Vanderbilt University
- John P. Wikswo
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Grant
Interconnections of multiple perfused engineered tissue constructs...
- Patent number 10,023,832
- Issue date Jul 17, 2018
- Vanderbilt University
- John P. Wikswo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Organ on chip integration and applications of the same
- Patent number 9,874,285
- Issue date Jan 23, 2018
- Vanderbilt University
- Frank E. Block
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Integrated human organ-on-chip microphysiological systems
- Patent number 9,725,687
- Issue date Aug 8, 2017
- President and Fellows of Harvard College
- John P. Wikswo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Normally closed microvalve and applications of the same
- Patent number 9,618,129
- Issue date Apr 11, 2017
- Vanderbilt University
- Frank E. Block
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Photolithographed micro-mirror well for 3D tomogram imaging of indi...
- Patent number 8,339,704
- Issue date Dec 25, 2012
- Vanderbilt University
- Kevin T. Seale
- G06 - COMPUTING CALCULATING COUNTING
Information Patent Grant
Bioreactors with an array of chambers and a common feed line
- Patent number 8,129,179
- Issue date Mar 6, 2012
- Vanderbilt University
- John F. Wikswo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Capillary perfused bioreactors with multiple chambers
- Patent number 8,003,378
- Issue date Aug 23, 2011
- Vanderbilt University
- John P. Wikswo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Device and methods for monitoring the status of at least one cell
- Patent number 7,981,649
- Issue date Jul 19, 2011
- Vanderbilt University
- John P. Wikswo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...

Patents Applicationslast 30 patents

Information Patent Application
DYNAMICALLY INTERCONNECTED MICROBIOREACTORS AND APPLICATIONS THEREOF
- Publication number 20240110143
- Publication date Apr 4, 2024
- Vanderbilt University
- John P. Wikswo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MICROFLUIDIC SYSTEMS FOR MULTIPLE BIOREACTORS AND APPLICATIONS OF SAME
- Publication number 20230338949
- Publication date Oct 26, 2023
- Vanderbilt University
- Ronald S. Reiserer
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
MICROFLUIDIC SYSTEMS FOR MULTIPLE BIOREACTORS AND APPLICATIONS OF SAME
- Publication number 20230271181
- Publication date Aug 31, 2023
- Vanderbilt University
- David K. Schaffer
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
VERTICAL-VIA ROTARY VALVES, MICROBIOREACTORS AND APPLICATIONS OF SAME
- Publication number 20230132012
- Publication date Apr 27, 2023
- Vanderbilt University
- David K. Schaffer
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
MICROFLUIDIC SYSTEMS, PUMPS, VALVES, FLUIDIC CHIPS THEREOF, AND APP...
- Publication number 20230122594
- Publication date Apr 20, 2023
- Vanderbilt University
- Ronald S. Reiserer
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
MASSIVELY PARALLEL, MULTIPLE-ORGAN PERFUSION CONTROL SYSTEM
- Publication number 20230121352
- Publication date Apr 20, 2023
- Vanderbilt University
- Ronald S. Reiserer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
CONTINUOUS AUTOMATED PERFUSION CULTURE ANALYSIS SYSTEM (CAPCAS) AND...
- Publication number 20230019924
- Publication date Jan 19, 2023
- Vanderbilt University
- Ronald S. Reiserer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MICROFLUIDIC SYSTEMS, PUMPS, VALVES, FLUIDIC CHIPS THEREOF, AND APP...
- Publication number 20220362769
- Publication date Nov 17, 2022
- Vanderbilt University
- Ronald S. Reiserer
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
ROBOTS AND ROBOTIC SYSTEMS FOR FLUID HANDLING AND TRANSPORT OF BIOD...
- Publication number 20220229441
- Publication date Jul 21, 2022
- Vanderbilt University
- Ronald S. Reiserer
- B60 - VEHICLES IN GENERAL
Information Patent Application
CONTINUOUS AUTOMATED PERFUSION CULTURE ANALYSIS SYSTEM (CAPCAS) AND...
- Publication number 20220135925
- Publication date May 5, 2022
- Vanderbilt University
- Ronald S. Reiserer
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
MULTICHANNEL PUMPS AND APPLICATIONS OF SAME
- Publication number 20220042506
- Publication date Feb 10, 2022
- Vanderbilt University
- John P. Wikswo
- F04 - POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS PUMPS FOR LIQUIDS OR ELASTIC...
Information Patent Application
CARTRIDGE SYSTEMS, CAPACITIVE PUMPS AND MULTI-THROW VALVES AND PUMP...
- Publication number 20210252510
- Publication date Aug 19, 2021
- Vanderbilt University
- David K. Schaffer
- F16 - ENGINEERING ELEMENTS AND UNITS GENERAL MEASURES FOR PRODUCING AND MAINT...
Information Patent Application
MULTICHANNEL PUMPS AND APPLICATIONS OF SAME
- Publication number 20210239109
- Publication date Aug 5, 2021
- Vanderbilt University
- John P. Wikswo
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
CARTRIDGE SYSTEMS, CAPACITIVE PUMPS AND MULTI-THROW VALVES AND PUMP...
- Publication number 20210197194
- Publication date Jul 1, 2021
- Vanderbilt University
- David K. Schaffer
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
MULTICOMPARTMENT MICROFLUIDIC BIOREACTORS, CYLINDRICAL ROTARY VALVE...
- Publication number 20210198607
- Publication date Jul 1, 2021
- Vanderbilt University
- John P. WIKSWO
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
DEVICES AND METHODS FOR TENSION MEASUREMENTS AND APPLICATIONS OF SAME
- Publication number 20200348218
- Publication date Nov 5, 2020
- Vanderbilt University
- John P. Wikswo
- G01 - MEASURING TESTING
Information Patent Application
PERISTALTIC MICROPUMP AND RELATED SYSTEMS AND METHODS
- Publication number 20200049140
- Publication date Feb 13, 2020
- Vanderbilt University
- Parker A. Gould
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
MULTICOMPARTMENT LAYERED AND STACKABLE MICROFLUIDIC BIOREACTORS AND...
- Publication number 20190336971
- Publication date Nov 7, 2019
- Vanderbilt University
- John P. Wikswo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SYSTEM AND METHOD FOR MICRODIALYSIS IMAGING AND REGIONAL FLUIDIC DE...
- Publication number 20190249128
- Publication date Aug 15, 2019
- Vanderbilt University
- John P. Wikswo
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
INTEGRATED ORGAN-ON-CHIP SYSTEMS AND APPLICATIONS OF THE SAME
- Publication number 20190064144
- Publication date Feb 28, 2019
- Vanderbilt University
- John P. Wikswo
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
DEVICES AND METHODS FOR TENSION MEASUREMENTS AND APPLICATIONS OF SAME
- Publication number 20190003941
- Publication date Jan 3, 2019
- Vanderbilt University
- John P. Wikswo
- G01 - MEASURING TESTING
Information Patent Application
MULTICOMPARTMENT LAYERED AND STACKABLE MICROFLUIDIC BIOREACTORS AND...
- Publication number 20180326417
- Publication date Nov 15, 2018
- Vanderbilt University
- John P. Wikswo
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
INTERCONNECTIONS OF MULTIPLE PERFUSED ENGINEERED TISSUE CONSTRUCTS...
- Publication number 20180298319
- Publication date Oct 18, 2018
- Vanderbilt University
- John P. Wikswo
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
PERISTALTIC MICROPUMP AND RELATED SYSTEMS AND METHODS
- Publication number 20180209552
- Publication date Jul 26, 2018
- Vanderbilt University
- Parker A. Gould
- B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
Information Patent Application
ORGAN ON CHIP INTEGRATION AND APPLICATIONS OF THE SAME
- Publication number 20180080570
- Publication date Mar 22, 2018
- Vanderbilt University
- Frank E. Block
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
INTERCONNECTIONS OF MULTIPLE PERFUSED ENGINEERED TISSUE CONSTRUCTS...
- Publication number 20170081625
- Publication date Mar 23, 2017
- Vanderbilt University
- John P. Wikswo
- A01 - AGRICULTURE FORESTRY ANIMAL HUSBANDRY HUNTING TRAPPING FISHING
Information Patent Application
HIGH-THROUGHPUT, MULTI-OMICS APPROACH TO DETERMINE AND VALIDATE DE...
- Publication number 20170082606
- Publication date Mar 23, 2017
- Vanderbilt University
- Richard CAPRIOLI
- G01 - MEASURING TESTING
Information Patent Application
NORMALLY CLOSED MICROVALVE AND APPLICATIONS OF THE SAME
- Publication number 20150308578
- Publication date Oct 29, 2015
- Vanderbilt University
- Frank E. Block
- F16 - ENGINEERING ELEMENTS AND UNITS GENERAL MEASURES FOR PRODUCING AND MAINT...
Information Patent Application
ORGAN ON CHIP INTEGRATION AND APPLICATIONS OF THE SAME
- Publication number 20150298123
- Publication date Oct 22, 2015
- Vanderbilt University
- Frank E. Block
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
INTEGRATED HUMAN ORGAN-ON-CHIP MICROPHYSIOLOGICAL SYSTEMS
- Publication number 20150004077
- Publication date Jan 1, 2015
- President and Fellows of Harvard College
- John P. Wikswo
- G01 - MEASURING TESTING

John P. Wikswo

Person

Patents Grantslast 30 patents

Continuous automated perfusion culture analysis system (CAPCAS) and...

Massively parallel, multiple-organ perfusion control system

Microfluidic systems, pumps, valves, fluidic chips thereof, and app...

Microfluidic systems, pumps, valves, fluidic chips thereof, and app...

Robots and robotic systems for fluid handling and transport of biod...

Cartridge systems, capacitive pumps and multi-throw valves and pump...

Continuous automated perfusion culture analysis system (CAPCAS) and...

Multichannel pumps and applications of same

Cartridge systems, capacitive pumps and multi-throw valves and pump...

Devices and methods for tension measurements and applications of same

Peristaltic micropump and related systems and methods

Devices and methods for tension measurements and applications of same

Bio-assessment device and method of making the device

High-throughput, multi-omics approach to determine and validate de...

Interconnections of multiple perfused engineered tissue constructs...

System and method for microdialysis imaging and regional fluidic de...

Multicompartment layered and stackable microfluidic bioreactors and...

Peristaltic micropump and related systems and methods

Multicompartment layered and stackable microfluidic bioreactors and...

Integrated organ-on-chip systems and applications of the same

Organ on chip integration and applications of the same

Integrated organ-on-chip systems and applications of the same

Interconnections of multiple perfused engineered tissue constructs...

Organ on chip integration and applications of the same

Integrated human organ-on-chip microphysiological systems

Normally closed microvalve and applications of the same

Photolithographed micro-mirror well for 3D tomogram imaging of indi...

Bioreactors with an array of chambers and a common feed line

Capillary perfused bioreactors with multiple chambers

Device and methods for monitoring the status of at least one cell

Patents Applicationslast 30 patents

DYNAMICALLY INTERCONNECTED MICROBIOREACTORS AND APPLICATIONS THEREOF

MICROFLUIDIC SYSTEMS FOR MULTIPLE BIOREACTORS AND APPLICATIONS OF SAME

MICROFLUIDIC SYSTEMS FOR MULTIPLE BIOREACTORS AND APPLICATIONS OF SAME

VERTICAL-VIA ROTARY VALVES, MICROBIOREACTORS AND APPLICATIONS OF SAME

MICROFLUIDIC SYSTEMS, PUMPS, VALVES, FLUIDIC CHIPS THEREOF, AND APP...

MASSIVELY PARALLEL, MULTIPLE-ORGAN PERFUSION CONTROL SYSTEM

CONTINUOUS AUTOMATED PERFUSION CULTURE ANALYSIS SYSTEM (CAPCAS) AND...

MICROFLUIDIC SYSTEMS, PUMPS, VALVES, FLUIDIC CHIPS THEREOF, AND APP...

ROBOTS AND ROBOTIC SYSTEMS FOR FLUID HANDLING AND TRANSPORT OF BIOD...

CONTINUOUS AUTOMATED PERFUSION CULTURE ANALYSIS SYSTEM (CAPCAS) AND...

MULTICHANNEL PUMPS AND APPLICATIONS OF SAME

CARTRIDGE SYSTEMS, CAPACITIVE PUMPS AND MULTI-THROW VALVES AND PUMP...

MULTICHANNEL PUMPS AND APPLICATIONS OF SAME

CARTRIDGE SYSTEMS, CAPACITIVE PUMPS AND MULTI-THROW VALVES AND PUMP...

MULTICOMPARTMENT MICROFLUIDIC BIOREACTORS, CYLINDRICAL ROTARY VALVE...

DEVICES AND METHODS FOR TENSION MEASUREMENTS AND APPLICATIONS OF SAME

PERISTALTIC MICROPUMP AND RELATED SYSTEMS AND METHODS

MULTICOMPARTMENT LAYERED AND STACKABLE MICROFLUIDIC BIOREACTORS AND...

SYSTEM AND METHOD FOR MICRODIALYSIS IMAGING AND REGIONAL FLUIDIC DE...

INTEGRATED ORGAN-ON-CHIP SYSTEMS AND APPLICATIONS OF THE SAME

DEVICES AND METHODS FOR TENSION MEASUREMENTS AND APPLICATIONS OF SAME

MULTICOMPARTMENT LAYERED AND STACKABLE MICROFLUIDIC BIOREACTORS AND...

INTERCONNECTIONS OF MULTIPLE PERFUSED ENGINEERED TISSUE CONSTRUCTS...

PERISTALTIC MICROPUMP AND RELATED SYSTEMS AND METHODS

ORGAN ON CHIP INTEGRATION AND APPLICATIONS OF THE SAME

INTERCONNECTIONS OF MULTIPLE PERFUSED ENGINEERED TISSUE CONSTRUCTS...

HIGH-THROUGHPUT, MULTI-OMICS APPROACH TO DETERMINE AND VALIDATE DE...

NORMALLY CLOSED MICROVALVE AND APPLICATIONS OF THE SAME

ORGAN ON CHIP INTEGRATION AND APPLICATIONS OF THE SAME

INTEGRATED HUMAN ORGAN-ON-CHIP MICROPHYSIOLOGICAL SYSTEMS