Marcella Nesi

Person

Saronno (VA), IT

People

Patents Grantslast 30 patents

Information Patent Grant
Substituted pyrazolo[4,3-h]quinazolines as choline kinase inhibitors
- Patent number 11,117,901
- Issue date Sep 14, 2021
- Nerviano Medical Sciences S.r.l.
- Alessandra Badari
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Purine and 3-deazapurine analogues as choline kinase inhibitors
- Patent number 10,683,292
- Issue date Jun 16, 2020
- Nerviano Medical Sciences S.r.l.
- Elena Casale
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted pyrroles active as kinases inhibitors
- Patent number 10,479,778
- Issue date Nov 19, 2019
- Nerviano Medical Sciences S.r.l.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted pyrroles active as kinases inhibitors
- Patent number 10,479,779
- Issue date Nov 19, 2019
- Nerviano Medical Sciences S.r.l.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitiors
- Patent number 10,478,423
- Issue date Nov 19, 2019
- Nerviano Medical Sciences S.r.l.
- Andrea Lombardi Borgia
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitors
- Patent number 10,081,622
- Issue date Sep 25, 2018
- Nerviano Medical Sciences S.r.l.
- Andrea Lombardi Borgia
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted pyrroles active as kinases inhibitors
- Patent number 10,071,986
- Issue date Sep 11, 2018
- Nerviano Medical Sciences S.r.l.
- Maria Gabriella Brasca
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitiors
- Patent number 10,028,934
- Issue date Jul 24, 2018
- Nerviano Medical Sciences S.r.l.
- Andrea Lombardi Borgia
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted pyrroles active as kinases inhibitors
- Patent number 9,688,661
- Issue date Jun 27, 2017
- Nerviano Medical Sciences S.r.l.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitors
- Patent number 9,616,059
- Issue date Apr 11, 2017
- Nerviano Medical Sciences S.r.l.
- Andrea Lombardi Borgia
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitiors
- Patent number 9,597,317
- Issue date Mar 21, 2017
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea Lombardi Borgia
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitors
- Patent number 9,408,850
- Issue date Aug 9, 2016
- Nerviano Medical Sciences S.r.l.
- Andrea Lombardi Borgia
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted pyrimidinyl-pyrroles active as kinase inhibitors
- Patent number 9,283,224
- Issue date Mar 15, 2016
- Nerviano Medical Sciences S.r.l.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitors
- Patent number 9,255,087
- Issue date Feb 9, 2016
- Nerviano Medical Sciences S.r.l.
- Andrea Lombardi Borgia
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitors
- Patent number 9,102,662
- Issue date Aug 11, 2015
- Nerviano Medical Sciences S.r.l.
- Andrea Lombardi Borgia
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitors
- Patent number 9,085,558
- Issue date Jul 21, 2015
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea Lombardi Borgia
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitors
- Patent number 9,029,356
- Issue date May 12, 2015
- Nerviano Medical Sciences S.r.l.
- Andrea Lombardi Borgia
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Alkynyl substituted pyrimidinyl-pyrroles active as kinases inhibitors
- Patent number 8,912,200
- Issue date Dec 16, 2014
- Nerviano Medical Sciences S.r.l.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
- Patent number 8,785,448
- Issue date Jul 22, 2014
- Nerviano Medical Sciences S.r.l.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitors
- Patent number 8,673,893
- Issue date Mar 18, 2014
- Nerviano Medical Sciences S.r.l.
- Andrea Lombardi Borgia
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
- Patent number 8,557,857
- Issue date Oct 15, 2013
- Nerviano Medical Sciences S.r.l.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
- Patent number 8,557,845
- Issue date Oct 15, 2013
- Nerviano Medical Sciences S.r.l.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
- Patent number 8,481,585
- Issue date Jul 9, 2013
- Nerviano Medical Sciences S.r.l.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitors
- Patent number 8,354,399
- Issue date Jan 15, 2013
- Nerviano Medical Sciences S.r.l.
- Maria Menichincheri
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted indazole derivatives active as kinase inhibitors
- Patent number 8,299,057
- Issue date Oct 30, 2012
- Nerviano Medical Sciences S.r.l.
- Andrea Lombardi Borgia
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase in...
- Patent number 8,173,659
- Issue date May 8, 2012
- Nerviano Medical Sciences S.r.l.
- Tiziano Bandiera
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Indazole derivatives as kinase inhibitors for the treatment of cancer
- Patent number 8,114,865
- Issue date Feb 14, 2012
- Nerviano Medical Sciences S.r.l.
- Tiziano Bandiera
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase in...
- Patent number 7,947,686
- Issue date May 24, 2011
- Nerviano Medical Sciences S.r.l.
- Tiziano Bandiera
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
- Patent number 7,407,971
- Issue date Aug 5, 2008
- Pfizer Italia S.R.L.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Process for preparing carboxamido-4-azasteroids
- Patent number 6,284,887
- Issue date Sep 4, 2001
- Pharmacia & Upjohn S.p.A.
- Achille Panzeri
- C07 - ORGANIC CHEMISTRY

Patents Applicationslast 30 patents

Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20220144813
- Publication date May 12, 2022
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea LOMBARDI BORGIA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20200377487
- Publication date Dec 3, 2020
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea LOMBARDI BORGIA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PYRAZOLO-QUINAZOLINE DERIVATIVES AS CHOLINE KINASE INHIBITORS
- Publication number 20200131188
- Publication date Apr 30, 2020
- NERVIANO MEDICAL SCIENCES S.R.L.
- Alessandra BADARI
- C07 - ORGANIC CHEMISTRY
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20190241546
- Publication date Aug 8, 2019
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea LOMBARDI BORGIA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
PURINE AND 3-DEAZAPURINE ANALOGUES AS CHOLINE KINASE INHIBITORS
- Publication number 20190225615
- Publication date Jul 25, 2019
- NERVIANO MEDICAL SCIENCES S.R.L.
- Elena CASALE
- C07 - ORGANIC CHEMISTRY
Information Patent Application
SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS
- Publication number 20180339978
- Publication date Nov 29, 2018
- NERVIANO MEDICAL SCIENCES S.R.L.
- Maria Gabriella Brasca
- C07 - ORGANIC CHEMISTRY
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITIORS
- Publication number 20180289672
- Publication date Oct 11, 2018
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea Lombardi Borgia
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS
- Publication number 20170253578
- Publication date Sep 7, 2017
- NERVIANO MEDICAL SCIENCES S.R.L.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS
- Publication number 20170253579
- Publication date Sep 7, 2017
- NERVIANO MEDICAL SCIENCES S.R.L.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20170158677
- Publication date Jun 8, 2017
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea Lombardi Borgia
- C07 - ORGANIC CHEMISTRY
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITIORS
- Publication number 20160311776
- Publication date Oct 27, 2016
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea Lombardi Borgia
- C07 - ORGANIC CHEMISTRY
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITIORS
- Publication number 20160310465
- Publication date Oct 27, 2016
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea Lombardi Borgia
- C12 - BIOCHEMISTRY BEER SPIRITS WINE VINEGAR MICROBIOLOGY ENZYMOLOGY MUTATION...
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20160095856
- Publication date Apr 7, 2016
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea Lombardi Borgia
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS
- Publication number 20150166512
- Publication date Jun 18, 2015
- NERVIANO MEDICAL SCIENCES S.R.L.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20150065520
- Publication date Mar 5, 2015
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea Lombardi Borgia
- C07 - ORGANIC CHEMISTRY
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20150057291
- Publication date Feb 26, 2015
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea Lombardi Borgia
- C07 - ORGANIC CHEMISTRY
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20150057292
- Publication date Feb 26, 2015
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea Lombardi Borgia
- C07 - ORGANIC CHEMISTRY
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20140228351
- Publication date Aug 14, 2014
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea LOMBARDI BORGIA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ALKYNYL SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASES INHIBITORS
- Publication number 20140194406
- Publication date Jul 10, 2014
- NERVIANO MEDICAL SCIENCES S.R.L.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASE INHIBITORS
- Publication number 20140155421
- Publication date Jun 5, 2014
- NERVIANO MEDICAL SCIENCES S.R.L.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20140080807
- Publication date Mar 20, 2014
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea Lombardi Borgia
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS
- Publication number 20130344031
- Publication date Dec 26, 2013
- NERVIANO MEDICAL SCIENCES S.R.L.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20130018036
- Publication date Jan 17, 2013
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea LOMBARDI BORGIA
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS
- Publication number 20130017170
- Publication date Jan 17, 2013
- NERVIANO MEDICAL SCIENCES S.R.L.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS
- Publication number 20130012507
- Publication date Jan 10, 2013
- NERVIANO MEDICAL SCIENCES S.R.L.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20110281843
- Publication date Nov 17, 2011
- NERVIANO MEDICAL SCIENCES S.R.L.
- Maria Menichincheri
- C07 - ORGANIC CHEMISTRY
Information Patent Application
SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE IN...
- Publication number 20110230470
- Publication date Sep 22, 2011
- NERVIANO MEDICAL SCIENCES S.R.L.
- Tiziano Bandiera
- C07 - ORGANIC CHEMISTRY
Information Patent Application
SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
- Publication number 20100292207
- Publication date Nov 18, 2010
- NERVIANO MEDICAL SCIENCES S.R.L.
- Andrea Lombardi Borgia
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER
- Publication number 20100197665
- Publication date Aug 5, 2010
- NERVIANO MEDICAL SCIENCES S.R.L.
- Tiziano Bandiera
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Substituted Pyrrolo-Pyrazole Derivatives as Kinase Inhibitors
- Publication number 20090082346
- Publication date Mar 26, 2009
- Pfizer Italia S.r.l.
- Maria Gabriella Brasca
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE

Marcella Nesi

Person

Patents Grantslast 30 patents

Substituted pyrazolo[4,3-h]quinazolines as choline kinase inhibitors

Purine and 3-deazapurine analogues as choline kinase inhibitors

Substituted pyrroles active as kinases inhibitors

Substituted pyrroles active as kinases inhibitors

Substituted indazole derivatives active as kinase inhibitiors

Substituted indazole derivatives active as kinase inhibitors

Substituted pyrroles active as kinases inhibitors

Substituted indazole derivatives active as kinase inhibitiors

Substituted pyrroles active as kinases inhibitors

Substituted indazole derivatives active as kinase inhibitors

Substituted indazole derivatives active as kinase inhibitiors

Substituted indazole derivatives active as kinase inhibitors

Substituted pyrimidinyl-pyrroles active as kinase inhibitors

Substituted indazole derivatives active as kinase inhibitors

Substituted indazole derivatives active as kinase inhibitors

Substituted indazole derivatives active as kinase inhibitors

Substituted indazole derivatives active as kinase inhibitors

Alkynyl substituted pyrimidinyl-pyrroles active as kinases inhibitors

Substituted pyrrolo-pyrazole derivatives as kinase inhibitors

Substituted indazole derivatives active as kinase inhibitors

Substituted pyrrolo-pyrazole derivatives as kinase inhibitors

Substituted pyrrolo-pyrazole derivatives as kinase inhibitors

Substituted pyrrolo-pyrazole derivatives as kinase inhibitors

Substituted indazole derivatives active as kinase inhibitors

Substituted indazole derivatives active as kinase inhibitors

Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase in...

Indazole derivatives as kinase inhibitors for the treatment of cancer

Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase in...

Substituted pyrrolo-pyrazole derivatives as kinase inhibitors

Process for preparing carboxamido-4-azasteroids

Patents Applicationslast 30 patents

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

PYRAZOLO-QUINAZOLINE DERIVATIVES AS CHOLINE KINASE INHIBITORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

PURINE AND 3-DEAZAPURINE ANALOGUES AS CHOLINE KINASE INHIBITORS

SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITIORS

SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS

SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITIORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITIORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

ALKYNYL SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASES INHIBITORS

SUBSTITUTED PYRIMIDINYL-PYRROLES ACTIVE AS KINASE INHIBITORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS

SUBSTITUTED PYRROLO-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE IN...

SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS

INDAZOLE DERIVATIVES AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER

Substituted Pyrrolo-Pyrazole Derivatives as Kinase Inhibitors