Mark E. Layton

Person

Harleysville, PA, US

People

Patents Grantslast 30 patents

Information Patent Grant
2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors
- Patent number 11,802,122
- Issue date Oct 31, 2023
- Merck Sharp & Dohme LLC
- Ashok Arasappan
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
2-amino-n-heteroaryl-nicotinamides as Nav1.8 inhibitors
- Patent number 11,377,438
- Issue date Jul 5, 2022
- Merck Sharp & Dohme LLC
- Ashok Arasappan
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Diamino-alkylamino-linked arylsulfonamide compounds with selective...
- Patent number 10,968,210
- Issue date Apr 6, 2021
- Merck Sharp & Dohme Corp.
- Thomas J. Greshock
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Diamino-alkylamino-linked arylsulfonamide compounds with selective...
- Patent number 10,519,147
- Issue date Dec 31, 2019
- Merck Sharp & Dohme Corp.
- Thomas J. Greshock
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
N1-phenylpropane-1,2-diamine compounds with selective activity in v...
- Patent number 10,442,778
- Issue date Oct 15, 2019
- Merck Sharp & Dohme Corp.
- Anthony J. Roecker
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Benzoxazolinone compounds with selective activity in voltage-gated...
- Patent number 9,624,208
- Issue date Apr 18, 2017
- Merck Sharp & Dohme Corp.
- Joseph E. Pero
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Bicycloamine-substituted-N-benzenesulfonamide compounds with select...
- Patent number 9,586,968
- Issue date Mar 7, 2017
- Merck Sharp & Dohme Corp.
- Mark E. Layton
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
N-substituted indazole sulfonamide compounds with selective activit...
- Patent number 9,388,179
- Issue date Jul 12, 2016
- Merck Sharp & Dohme Corp.
- Joseph E. Pero
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Imidazopyridin-2-one derivatives
- Patent number 9,315,518
- Issue date Apr 19, 2016
- Merck Sharp & Dohme Corp.
- Hannah D. Fiji
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Benzoxazolinone compounds with selective activity in voltage-gated...
- Patent number 9,273,040
- Issue date Mar 1, 2016
- Merck Sharp & Dohme Corp.
- Mark E. Layton
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Positive allosteric modulators of mGluR2
- Patent number 9,108,937
- Issue date Aug 18, 2015
- Merck Sharp & Dohme Corp.
- Mark E. Layton
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Pyrimidine PDE10 inhibitors
- Patent number 9,062,059
- Issue date Jun 23, 2015
- Merck Sharp & Dohme Corp.
- Christopher D. Cox
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Positive allosteric modulators of MGLUR2
- Patent number 8,993,779
- Issue date Mar 31, 2015
- Merck Sharp & Dohme Corp.
- Vadim Y. Dudkin
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted 1,3-benzothiazol-2(3H)-ones and [1,3]thiazolo[5,4-B]pyr...
- Patent number 8,952,005
- Issue date Feb 10, 2015
- Merck Sharp & Dohme Corp.
- Mark E. Layton
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Positive allosteric modulators of MGLUR2
- Patent number 8,765,784
- Issue date Jul 1, 2014
- Merck Sharp & Dohme Corp.
- Kenneth L. Arrington
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Inhibitors of AKT activity
- Patent number 8,536,193
- Issue date Sep 17, 2013
- Merck Sharp & Dohme Corp.
- Hidetomo Furuyama
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Combination cancer therapy with an AKT inhibitor and other anticanc...
- Patent number 8,481,503
- Issue date Jul 9, 2013
- Merck Sharp & Dohme Corp.
- Mark E. Layton
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Substituted naphthyridine compounds as inhibitors of Akt activity
- Patent number 8,288,407
- Issue date Oct 16, 2012
- Merck Sharp & Dohme Corp.
- Michael J. Kelly, III
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Substituted [1,2,4]triazolo[4′,3′:1,6]pyrido[2,3-b]pyrazines of the...
- Patent number 8,207,169
- Issue date Jun 26, 2012
- MSD K.K.
- Hidetomo Furuyama
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Inhibitors of AKT activity
- Patent number 8,168,652
- Issue date May 1, 2012
- Merck Sharp & Dohme Corp.
- Philip E. Sanderson
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Grant
Inhibitors of akt activtiy
- Patent number 8,008,317
- Issue date Aug 30, 2011
- Merck Sharp & Dohme Corp.
- Donna J. Armstrong
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Inhibitors of Akt activity
- Patent number 7,910,561
- Issue date Mar 22, 2011
- Merck Sharp & Dohme Corp.
- Jeannie M. Arruda
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Inhibitors of Akt activity
- Patent number 7,589,068
- Issue date Sep 15, 2009
- Merck & Co., Inc.
- Nicholas D. P. Cosford
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
Inhibitors of Akt activity
- Patent number 7,576,209
- Issue date Aug 18, 2009
- Merck & Co., Inc.
- Michael J. Kelly, III
- C07 - ORGANIC CHEMISTRY
Information Patent Grant
4-cycloakylaminopyrazolo pyrimidine NMDA/NR2B antagonists
- Patent number 7,452,893
- Issue date Nov 18, 2008
- Merck & Co., Inc.
- Wayne Thompson
- C07 - ORGANIC CHEMISTRY

Patents Applicationslast 30 patents

Information Patent Application
PRODRUGS OF 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
- Publication number 20240287124
- Publication date Aug 29, 2024
- Merck Sharp & Dohme LLC
- Mark W. Embrey
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CA...
- Publication number 20240246932
- Publication date Jul 25, 2024
- Merck Sharp & Dohme LLC
- Ashok Arasappan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION
- Publication number 20240228535
- Publication date Jul 11, 2024
- Merck Sharp & Dohme LLC
- John J. Acton
- C07 - ORGANIC CHEMISTRY
Information Patent Application
2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS
- Publication number 20230312528
- Publication date Oct 5, 2023
- Merck Sharp & Dohme LLC
- Ashok Arasappan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS
- Publication number 20230227405
- Publication date Jul 20, 2023
- Merck Sharp & Dohme LLC
- Ashok Arasappan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
2-OXO-OXAZOLIDINE-5-CARBOXAMIDES AS NAV1.8 INHIBITORS
- Publication number 20230227441
- Publication date Jul 20, 2023
- Merck Sharp & Dohme LLC
- Ashok Arasappan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
CYCLOALKYL 3-OXOPIPERAZINE CARBOXAMIDES AND CYCLOHETEROALKYL 3-OXOP...
- Publication number 20220380338
- Publication date Dec 1, 2022
- Merck Sharp & Dohme LLC
- Ashok Arasappan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
HYDROXYPYRROLIDINE-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELEC...
- Publication number 20220305035
- Publication date Sep 29, 2022
- MERCK SHARP & DOHME CORP.
- Anthony J. Roecker
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS
- Publication number 20220289710
- Publication date Sep 15, 2022
- Merck Sharp & Dohme LLC
- Ashok Arasappan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
2-AMINO-N-PHENYL-NICOTINAMIDES AS NAV1.8 INHIBITORS
- Publication number 20220119363
- Publication date Apr 21, 2022
- MERCK SHARP & DOHME CORP.
- Michael J. Breslin
- C07 - ORGANIC CHEMISTRY
Information Patent Application
4-AMINO OR 4-ALKOXY-SUBSTITUTED ARYL SULFONAMIDE COMPOUNDS WITH SEL...
- Publication number 20220000844
- Publication date Jan 6, 2022
- MERCK SHARP & DOHME CORP.
- Christopher J. Bungard
- C07 - ORGANIC CHEMISTRY
Information Patent Application
2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS
- Publication number 20210403457
- Publication date Dec 30, 2021
- MERCK SHARP & DOHME CORP.
- Ashok Arasappan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS
- Publication number 20210387966
- Publication date Dec 16, 2021
- MERCK SHARP & DOHME CORP.
- Ashok Arasappan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS
- Publication number 20200140411
- Publication date May 7, 2020
- MERCK SHARP & DOHME CORP.
- Ashok Arasappan
- C07 - ORGANIC CHEMISTRY
Information Patent Application
DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE...
- Publication number 20200131167
- Publication date Apr 30, 2020
- MERCK SHARP & DOHME CORP.
- Thomas J. Greshock
- C07 - ORGANIC CHEMISTRY
Information Patent Application
N1-PHENYLPROPANE-1,2-DIAMINE COMPOUNDS WITH SELECTIVE ACTIVITY IN V...
- Publication number 20190092738
- Publication date Mar 28, 2019
- Merck Sharp & Dohme Corp.
- Anthony J. Roecker
- C07 - ORGANIC CHEMISTRY
Information Patent Application
DIAMINO-ALKYLAMINO-Linked ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE...
- Publication number 20180362518
- Publication date Dec 20, 2018
- MERCK SHARP & DOHME CORP.
- Thomas J. Greshock
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
BICYCLOAMINE-SUBSTITUTED-N-BENZENESULFONAMIDE COMPOUNDS WITH SELECT...
- Publication number 20170002008
- Publication date Jan 5, 2017
- MERCK SHARP & DOHME CORP.
- Mark E. Layton
- C07 - ORGANIC CHEMISTRY
Information Patent Application
N-SUBSTITUTED INDAZOLE SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVIT...
- Publication number 20150284389
- Publication date Oct 8, 2015
- MERCK SHARP & DOHME CORP.
- Joseph E. Pero
- C07 - ORGANIC CHEMISTRY
Information Patent Application
BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED...
- Publication number 20150252034
- Publication date Sep 10, 2015
- Joseph E. Pero
- C07 - ORGANIC CHEMISTRY
Information Patent Application
IMIDAZOPYRIDIN-2-ONE DERIVATIVES
- Publication number 20140350002
- Publication date Nov 27, 2014
- MERCK SHARP & DOHME CORP.
- Hannah D. Fiji
- C07 - ORGANIC CHEMISTRY
Information Patent Application
BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED...
- Publication number 20140303143
- Publication date Oct 9, 2014
- Mark E. Layton
- C07 - ORGANIC CHEMISTRY
Information Patent Application
PYRIMIDINE PDE10 INHIBITORS
- Publication number 20140228368
- Publication date Aug 14, 2014
- Christopher D. Cox
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
SUBSTITUTED 1,3-BENZOTHIAZOL-2(3H)-ONES AND [1,3]THIAZOLO[5,4-B]PYR...
- Publication number 20140045829
- Publication date Feb 13, 2014
- MERCK SHARP & DOHME CORP.
- MARK E. LAYTON
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
POSITIVE ALLOSTERIC MODULATORS OF MGLUR2
- Publication number 20130210768
- Publication date Aug 15, 2013
- Kenneth L. Arrington
- C07 - ORGANIC CHEMISTRY
Information Patent Application
ISOINDOLINE PDE10 INHIBITORS
- Publication number 20130203756
- Publication date Aug 8, 2013
- Jamie L. Bunda
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
POSITIVE ALLOSTERIC MODULATORS OF MGLUR2
- Publication number 20130158002
- Publication date Jun 20, 2013
- Mark E. Layton
- C07 - ORGANIC CHEMISTRY
Information Patent Application
POSITIVE ALLOSTERIC MODULATORS OF MGLUR2
- Publication number 20130143880
- Publication date Jun 6, 2013
- Vadim Y. Dudkin
- C07 - ORGANIC CHEMISTRY
Information Patent Application
Substituted 1,3-Benzothiazol-2(3H)-Ones and [1,3]Thiazolo[5,4-B]Pyr...
- Publication number 20130035332
- Publication date Feb 7, 2013
- Mark E. Layton
- A61 - MEDICAL OR VETERINARY SCIENCE HYGIENE
Information Patent Application
INHIBITORS OF AKT ACTIVITY
- Publication number 20120252806
- Publication date Oct 4, 2012
- Michael J. Kelly, III
- C07 - ORGANIC CHEMISTRY

Mark E. Layton

Person

Patents Grantslast 30 patents

2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors

2-amino-n-heteroaryl-nicotinamides as Nav1.8 inhibitors

Diamino-alkylamino-linked arylsulfonamide compounds with selective...

Diamino-alkylamino-linked arylsulfonamide compounds with selective...

N1-phenylpropane-1,2-diamine compounds with selective activity in v...

Benzoxazolinone compounds with selective activity in voltage-gated...

Bicycloamine-substituted-N-benzenesulfonamide compounds with select...

N-substituted indazole sulfonamide compounds with selective activit...

Imidazopyridin-2-one derivatives

Benzoxazolinone compounds with selective activity in voltage-gated...

Positive allosteric modulators of mGluR2

Pyrimidine PDE10 inhibitors

Positive allosteric modulators of MGLUR2

Substituted 1,3-benzothiazol-2(3H)-ones and [1,3]thiazolo[5,4-B]pyr...

Positive allosteric modulators of MGLUR2

Inhibitors of AKT activity

Combination cancer therapy with an AKT inhibitor and other anticanc...

Substituted naphthyridine compounds as inhibitors of Akt activity

Substituted [1,2,4]triazolo[4′,3′:1,6]pyrido[2,3-b]pyrazines of the...

Inhibitors of AKT activity

Inhibitors of akt activtiy

Inhibitors of Akt activity

Inhibitors of Akt activity

Inhibitors of Akt activity

4-cycloakylaminopyrazolo pyrimidine NMDA/NR2B antagonists

Patents Applicationslast 30 patents

PRODRUGS OF 4'-SUBSTITUTED NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

ARYL 3-OXOPIPERAZINE CARBOXAMIDES AND HETEROARYL 3-OXOPIPERAZINE CA...

PROTEASE INHIBITORS FOR TREATING OR PREVENTING CORONAVIRUS INFECTION

2-OXO-IMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS

5-OXOPYRROLIDINE-3-CARBOXAMIDES AS NAV1.8 INHIBITORS

2-OXO-OXAZOLIDINE-5-CARBOXAMIDES AS NAV1.8 INHIBITORS

CYCLOALKYL 3-OXOPIPERAZINE CARBOXAMIDES AND CYCLOHETEROALKYL 3-OXOP...

HYDROXYPYRROLIDINE-SUBSTITUTED ARYLSULFONAMIDE COMPOUNDS WITH SELEC...

2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS

2-AMINO-N-PHENYL-NICOTINAMIDES AS NAV1.8 INHIBITORS

4-AMINO OR 4-ALKOXY-SUBSTITUTED ARYL SULFONAMIDE COMPOUNDS WITH SEL...

2-OXOIMIDAZOLIDINE-4-CARBOXAMIDES AS NAV1.8 INHIBITORS

2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS

2-AMINO-N-HETEROARYL-NICOTINAMIDES AS NAV1.8 INHIBITORS

DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE...

N1-PHENYLPROPANE-1,2-DIAMINE COMPOUNDS WITH SELECTIVE ACTIVITY IN V...

DIAMINO-ALKYLAMINO-Linked ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE...

BICYCLOAMINE-SUBSTITUTED-N-BENZENESULFONAMIDE COMPOUNDS WITH SELECT...

N-SUBSTITUTED INDAZOLE SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVIT...

BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED...

IMIDAZOPYRIDIN-2-ONE DERIVATIVES

BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED...

PYRIMIDINE PDE10 INHIBITORS

SUBSTITUTED 1,3-BENZOTHIAZOL-2(3H)-ONES AND [1,3]THIAZOLO[5,4-B]PYR...

POSITIVE ALLOSTERIC MODULATORS OF MGLUR2

ISOINDOLINE PDE10 INHIBITORS

POSITIVE ALLOSTERIC MODULATORS OF MGLUR2

POSITIVE ALLOSTERIC MODULATORS OF MGLUR2

Substituted 1,3-Benzothiazol-2(3H)-Ones and [1,3]Thiazolo[5,4-B]Pyr...

INHIBITORS OF AKT ACTIVITY